Cancer is a class of diseases characterized by the cell growth irregularly and disorderly in the body tissue.
Most cases of cancer start in the cell on the surface of the inner lining of the tissue of the organ. In the early stage, due to the small size of the tumor, most patients do not experience any symptoms.
However, in the advanced stage, most cancer can cause bleeding and serious pain if the large size has pressed on the blood vessels and nearby nerve cells. In this stage, cancerous cells may travel a distance away from the original site to infect other tissue and organs, leading to secondary metastasis.
Researchers do not know what causes cancer? but epidemiological studies suggested that genetic mutation inherited from the parent and acquired genetic alternation due to smoking, radiation, viruses, carcinogens, are associated with the onset of the diseases.
Some researchers also strongly indicated obesity-induced hormones change and, chronic inflammation is a major risk factor involved the development of cancers in the Western world
Dr. Karen Basen-Engquis, the lead scientist in the cancer team wrote, "The prevalence of overweight and obesity is increasing worldwide, and the evidence base for a link between obesity and cancer is growing. In the United States, approximately 85,000 new cancer cases per year are related to obesity".
And, "Recent research has found that as the body mass index increases by 5 kg/m2, cancer mortality increases by 10%. Additionally, studies of patients who have had bariatric surgery for weight loss report reductions in cancer incidence and mortality, particularly for women".
These results clearly suggested reducing weight through diet and exercise or surgery may be the best way for attenuating the risk of cancer onset.
Alfalfa is a flowering plant in the genus Medicago, belonging to the family Fabaceae, It has been cultivated all over the world as hay for cattle feeding. The leaves, sprouts, and seeds have been used in traditional medicine over thousands of years to treat high cholesterol, asthma, osteoarthritis, rheumatoid arthritis, diabetes, enhance the digestive system, bleeding disorder, kidney, and urinary tract infection, etc.
North America aboriginal has used Alfalfa seed as food, such as making bread and mush.
It chemical constituents include flavones, isoflavones, sterols, Bichanin A Coumestrol Diadzein Formonetin Genisteincoumarin derivatives, etc.
With an aim to find the natural ingredient or herbal remedy, researchers looked into L-Canavanine, a potentially toxic antimetabolite of L-arginine stored by sprouts, and in ten varieties of the seed of alfalfa, against a number of animal-bearing carcinomas and cancer cell lines.
The young plant exerted the strongest anti-cancer effects measured by the stored appreciable canavanine ranged from 1.3 to 2.4%, compared to that 1.54 of the seed.
Alfalfa seed canavanine content levels were also found in the seeds of other members of the genus Canavalia, which are amongst the more abundant sources of this antimetabolite.
Dr, Watanabe K, and colleagues in the examining anti-colon cancer effect of dietary alfalfa, pectin, and wheat bran in female inbred F344 rats by given at 7 weeks of age, a dose of azoxymethane (AOM) of 8 mg/kg body weight/week for 10 weeks or methylnitrosourea (MNU) intrarectally at a dose rate of 2 mg/rat twice a week for 3 weeks.sugegsted
Examine the results from the autopsies at the 40 weeks and the MNU-treated group 30 weeks after the first injection of the carcinogen, showed no tumors in the colon or other organs of untreated rats fed the various diets.
The animals fed the alfalfa diet and treated with MNU had a higher incidence of colon tumors than did those fed the control diet or the diets containing pectin or wheat bran.
The incidence of MNU-induced colon tumors did not differ between the animals fed the control diet or the diets containing pectin or wheat bran.
The incidence of AOM-induced colon tumors in rats fed diets containing pectin or wheat bran was lower than that in rats fed the control diet or the alfalfa diet.
These results clearly suggested that the effect of fiber in colon carcinogenesis depends on the type of fiber and, possibly, the fiber's mode of action.
Taken altogether, the conflict results indicated that further studies are necessary before herbal Alfalfa can be used for the prevention and combined with other therapy for the treatment of cancer.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The natural abundance of L-canavanine, an active anticancer agent, in alfalfa, medicago sativa (L.). by Rosenthal GA, Nkomo P.(PubMed)
(2) Effect of dietary alfalfa, pectin, and wheat bran on azoxymethane-or methylnitrosourea-induced colon carcinogenesis in F344 rats. by Watanabe K, Reddy BS, Weisburger JH, Kritchevsky D.(PubMed)
(3) Obesity and Cancer Risk: Recent Review and Evidence by Karen Basen-Engquist
and Maria Chang. (PMC)
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