Andrographis, the forgotten herbal medicine may consist of a potency in reduced risk and treatment of skin cancer with fewer or no side effects, the renowned institute study suggested.
Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka. It has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,.....
Skin cancer is a medical condition of uncontrolled growth of abnormal skin cells and often detected at an early stage.
According to the joint study lead by the Sri Krishnadevaraya University, the leaf extract of Andrographis nallamalayana (AN) significantly reduced the viability and survival of cells in skin cancer cell lines on A375 and B16F10 as shown in MTT assay and clonogenic assays.
The anti-skin cancer effects of the leaf extract were also associated to ameliorate the expression of Bcl-2, an anti-apoptotic protein in induced the expression of pro-apoptotic mechanism.
Dr. Purushotham G, the lead author said, "the extracts of AN exhibited significant anti-proliferative, anti-inflammatory and pro-apoptotic activities on melanoma skin cancer cell lines"
In immunofluorescence analysis, leaf extract Andrographis nallamalayana (AN), significantly attenuate the expression of NF-κB target genes with function in regulated cytotoxicity expression in the tumor cell.
Furthermore, the extract also exhibited the direct anticancer activity on cancer cells by cell-cycle arrest at the G0/G1 phase through induction of cell-cycle inhibitory protein p27 involved cell proliferation and decreased expression of cyclin-dependent kinase 4 (CDK4) in cell controlling, probably through enhancing immunomodulatory property.
Taking together, there is no doubt that Andrographis processes a pharmaceutical value in reduced risk and controlling skin cancer, but the intake of large quantities can only be prescribed by an herbalist.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) In vitro evaluation of anti-proliferative, anti-inflammatory and pro-apoptotic activities of the m ethanolic extracts of Andrographis nallamalayana Ellis on A375 and B16F10 melanoma cell lines by Purushotham G1,2, Padma Y1, Nabiha Y2, Venkata Raju RR3.(PubMed)
(2) Andrographolide, a potential cancer therapeutic agent isolated from Andrographispaniculata by Rajagopal S1, Kumar RA, Deevi DS, Satyanarayana C, Rajagopalan R.(PubMed)
Thursday, January 9, 2020
Herbal Artichoke, the Best for the Treatment of Chronic Constipation
Constipation is a condition of hard and dry stool that is infrequent or hard to pass.
Acute constipation reversed in a few days mostly is caused by staying in a sitting position for long periods of time that kinks up your colon and restrain stool from passing through.
Chronic constipation is a condition characterized by difficult, infrequent, or perceived incomplete evacuation of bowel movements with less than 3 bowel movement a week,
Chronic constipation other than structural and medical problems is normally caused by a diet with low fiber accompanied by the intake of certain medications such as calcium channel blockers, narcotics.
The total fiber intake per day is 25-35 grams, is recommended for people with constipation and general health, depending on your sex, age, and weight.
If you are taking the requirement of fiber daily, but experience symptoms of excess colon gas and flatus, you should cut down on soluble fiber first.
In order to maintain good colon health against constipation, people with chronic constipation with no structural and medical problems should follow a high fiber diet accompanied by increased fluid intake and moderate exercise.
Some researchers suggested that there is a correlation between psychological disorders such as depression in the risk of constipation.
Dr. Janique G. Jessurun, in the study the relationship between psychiatric diagnoses and constipation wrote, "In the stratum of patients older than 60 years, all psychiatric categories except for substance-related disorders were significantly associated with a higher prevalence of constipation".
And, " In the elderly, all measured psychiatric diagnoses are strongly associated with an increased prevalence of constipation".
In other words, adults who are 60 years of age and over with psychiatric disorders are at a higher risk of constipation.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine for as liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researcher on the finding a natural therapeutics for chronic constipation researchers evaluated the effects of probiotic-enriched artichokes on treatment preference, symptom profile and short-chain fatty acid (SCFA) production in constipated subjects, compared with ordinary artichokes.
The double-blind method included 20 constipated patients (3M/17F; 38.8 ± 14.4 years) using a computer-generated randomization list. Each patient consumed 180 g per day of ordinary artichokes or artichokes enriched with Lactobacillus paracasei IMPC 2.1 for 15 days (daily dose of 2 × 10(10) CFU).
80% of participants preferred probiotic-enriched artichokes to ordinary ones. Satisfactory relief of symptoms was significantly higher (P = 0.0014) during the probiotic-enriched artichoke period.
The Bristol chart cluster scores were significantly higher in the combined treatment group (3.3 ± 1.2, 2.9 ± 1.3 2.2 ± 1.2) compared to the baseline, ordinary artichokes, and probiotic-enriched ones, respectively.
Furthermore, GSRS constipation was significantly lower (13.9 ± 0.9, 10.2 ± 0.8, 8.3 ± 0.9; P = 0.032) in the combined treatment group compared to the probiotic group and baseline.
Based on the findings, researchers wrote, "This trial shows a positive effect on symptoms in constipated patients after intake of probiotic-enriched artichokes".
In order to understand more information about artichoke in the promotion of constipation, researchers assessed the suitability of some vegetables, particularly olives and artichokes, to vehicle probiotic strains into the gastrointestinal tract.
The study included 8 volunteers (3M/5F age 40+/-14 y) integrated their normal diet with artichokes (180 gr) enriched with 20 billions of L. paracasei LMGP22043 for 15 days.
There were no significant differences in the microbiological counts throughout the experimental period. However, the treatment group showed a significant increase of butyric and valeric acids with a concomitant decrease of lactic acid.
The treatment also reduced the fecal beta-glucuronidase activity and abdominal distension and feeling of incomplete evacuation.
Taken altogether, artichoke combined with probiotics may be considered a functional formula for the treatment of patients with chronic constipation with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Randomised clinical trial: efficacy of Lactobacillus paracasei-enriched artichokes in the treatment of patients with functional constipation--a double-blind, controlled, crossover study by Riezzo G1, Orlando A, D'Attoma B, Guerra V, Valerio F, Lavermicocca P, De Candia S, Russo F.(PubMed)
(2) Effects of probiotic Lactobacillus paracasei-enriched artichokes on constipated patients: a pilot study by Valerio F1, Russo F, de Candia S, Riezzo G, Orlando A, Lonigro SL, Lavermicocca P. (PubMed)
(3) The Relation between Psychiatric Diagnoses and Constipation in Hospitalized Patients: A Cross-Sectional Study by Janique G. Jessurun,1,2 Peter N. van Harten,1,3 Toine C. G. Egberts,2,4 Ysbrand J. Pijl,1 Ingeborg Wilting,2,4 and Diederik E. Tenback. (Hindawi)
Acute constipation reversed in a few days mostly is caused by staying in a sitting position for long periods of time that kinks up your colon and restrain stool from passing through.
Chronic constipation is a condition characterized by difficult, infrequent, or perceived incomplete evacuation of bowel movements with less than 3 bowel movement a week,
Chronic constipation other than structural and medical problems is normally caused by a diet with low fiber accompanied by the intake of certain medications such as calcium channel blockers, narcotics.
The total fiber intake per day is 25-35 grams, is recommended for people with constipation and general health, depending on your sex, age, and weight.
If you are taking the requirement of fiber daily, but experience symptoms of excess colon gas and flatus, you should cut down on soluble fiber first.
In order to maintain good colon health against constipation, people with chronic constipation with no structural and medical problems should follow a high fiber diet accompanied by increased fluid intake and moderate exercise.
Some researchers suggested that there is a correlation between psychological disorders such as depression in the risk of constipation.
Dr. Janique G. Jessurun, in the study the relationship between psychiatric diagnoses and constipation wrote, "In the stratum of patients older than 60 years, all psychiatric categories except for substance-related disorders were significantly associated with a higher prevalence of constipation".
And, " In the elderly, all measured psychiatric diagnoses are strongly associated with an increased prevalence of constipation".
In other words, adults who are 60 years of age and over with psychiatric disorders are at a higher risk of constipation.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine for as liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researcher on the finding a natural therapeutics for chronic constipation researchers evaluated the effects of probiotic-enriched artichokes on treatment preference, symptom profile and short-chain fatty acid (SCFA) production in constipated subjects, compared with ordinary artichokes.
The double-blind method included 20 constipated patients (3M/17F; 38.8 ± 14.4 years) using a computer-generated randomization list. Each patient consumed 180 g per day of ordinary artichokes or artichokes enriched with Lactobacillus paracasei IMPC 2.1 for 15 days (daily dose of 2 × 10(10) CFU).
80% of participants preferred probiotic-enriched artichokes to ordinary ones. Satisfactory relief of symptoms was significantly higher (P = 0.0014) during the probiotic-enriched artichoke period.
The Bristol chart cluster scores were significantly higher in the combined treatment group (3.3 ± 1.2, 2.9 ± 1.3 2.2 ± 1.2) compared to the baseline, ordinary artichokes, and probiotic-enriched ones, respectively.
Furthermore, GSRS constipation was significantly lower (13.9 ± 0.9, 10.2 ± 0.8, 8.3 ± 0.9; P = 0.032) in the combined treatment group compared to the probiotic group and baseline.
Based on the findings, researchers wrote, "This trial shows a positive effect on symptoms in constipated patients after intake of probiotic-enriched artichokes".
In order to understand more information about artichoke in the promotion of constipation, researchers assessed the suitability of some vegetables, particularly olives and artichokes, to vehicle probiotic strains into the gastrointestinal tract.
The study included 8 volunteers (3M/5F age 40+/-14 y) integrated their normal diet with artichokes (180 gr) enriched with 20 billions of L. paracasei LMGP22043 for 15 days.
There were no significant differences in the microbiological counts throughout the experimental period. However, the treatment group showed a significant increase of butyric and valeric acids with a concomitant decrease of lactic acid.
The treatment also reduced the fecal beta-glucuronidase activity and abdominal distension and feeling of incomplete evacuation.
Taken altogether, artichoke combined with probiotics may be considered a functional formula for the treatment of patients with chronic constipation with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Randomised clinical trial: efficacy of Lactobacillus paracasei-enriched artichokes in the treatment of patients with functional constipation--a double-blind, controlled, crossover study by Riezzo G1, Orlando A, D'Attoma B, Guerra V, Valerio F, Lavermicocca P, De Candia S, Russo F.(PubMed)
(2) Effects of probiotic Lactobacillus paracasei-enriched artichokes on constipated patients: a pilot study by Valerio F1, Russo F, de Candia S, Riezzo G, Orlando A, Lonigro SL, Lavermicocca P. (PubMed)
(3) The Relation between Psychiatric Diagnoses and Constipation in Hospitalized Patients: A Cross-Sectional Study by Janique G. Jessurun,1,2 Peter N. van Harten,1,3 Toine C. G. Egberts,2,4 Ysbrand J. Pijl,1 Ingeborg Wilting,2,4 and Diederik E. Tenback. (Hindawi)
Herbal Calendula, Protects Lipid, Protein and Cells DNA Against Damage Caused by Oxidative Stress
Scientists may have found a natural remedy for the prevention and treatment of the diseases associated with the expression of oxidative stress, according to studies.
Antioxidants are stable molecules that inhibit the oxidation induced by free radicals.
Free radicals are unstable and high reactive molecules with a single electron in the outer ring.
In order for them to become stable, free radicals are ready to donate or intercept an electron from other molecules, leading to a chain reaction that cannot be stopped until the electrons on the outer ring are paired or inhibited by antioxidants.
Oxidative stress is a condition caused by either overexpression of free radical or low levels of antioxidant enzymes produced by the host body.
In other words, the unbalanced ratio of the levels of free radicals and antioxidants enzymes is the major cause of the onset of oxidative stress, leading to the damage of lipid, DNA, and protein in the cells of the host.
Although there are many risk factors associated with the development of the condition, some researchers suggested that smoking is one of the preventable and major risks in the induction of the onset of oxidative stress.
Dr. Isik B in the comparison of the risk of oxidative stress in smokers and nonsmokers wrote, "Smoking may enhance oxidative stress not only through the production of reactive oxygen radicals in smoke but also through the weakening of the antioxidant defense systems".
And, ": The serum MDA levels were significantly higher (p < .05) and serum PON1 activities were significantly lower (p < .001) in smokers than in nonsmokers".
Where serum malondialdehyde (MDA) is an oxidative stress marker and paraoxonase (PON1) is an HDL-associated enzyme that protects the HDL against oxidation.
Calendula is also known as pot marigold, annual or perennial herbaceous plants of about 12–20 species of genus Calendula, belonging to the family Asteraceae, native to Southern Europe.
The herbal medicine has been used in herbal medicine as spasmolytic, spasmogenic, inflammatory effects and for the treatment of abdominal cramps, wound healing, skin diseases, colitis, constipation, etc.
Besides major chemical constituents of triterpenoids, flavonoids, coumarines, quinones, volatile oil, carotenoids, and amino acids, the herb also contains loliolide (calendin), calendulin and n-paraffins.
Researchers on finding herbal medicine which process a high amount of antioxidants examined the
Calendula officinalis flower extract effects against experimentally induced thermal burns made on the shaven back of the rats under anesthesia in rats.
The animals then are treated orally with different doses of the flower extracts (20 mg, 100 mg, and 200 mg/kg body weight).
Injection of the extracts showed significant improvement in healing when compared with the control untreated animals.
The wound healing is observed by the speeding up through the increase of the concentration of collagen contents in the treated group.
The acute phase proteins associated with the oxidative activity was increased due to burning were found to be decreased significantly in 200 mg/kg body weight extract-treated animals.
The antioxidant defense mechanism decreased in the liver during burn injury, was found to be enhanced in treated animals.
The lipid peroxidation was significantly lowered in the treated group, accompanied by a decrease of the tissue damage marker compared to control animals.
Furthermore, in the investigation of the Flower extract of C. officinalis L. protective effect against CCl4 induced acute hepatotoxicity and cisplatin-induced nephrotoxicity, pretreatment of the flower extract at 100 and 250 mg/kg body weight exerted a significant reduction of the tissue and oxidative stress markers compared to the untreated group.
The extract displayed a liver protective effect observed by the decreased levels of lipid peroxidation the marker of membrane damage and the total bilirubin content in the liver.
Moreover, the herbal extract also demonstrated kidney protective effects observed by the reduced levels of the kidney function markers, urea, and creatinine which were significantly increased in cisplatin-treated animals.
Additionally, the cisplatin-induced myelosuppression was ameliorated by the extract pretreatment, by enhancing the levels of antioxidant enzymes, such as superoxide dismutase and catalase and glutathione.
Dr. Preethi KC, the lead scientist wrote in the final report, "Possible mechanism of action of the flower extract may be due to its antioxidant activity and reduction of oxygen radicals".
Taken altogether, herbal Calendula may be considered a functional remedy for the protection of our body against disease associated with oxidative stress, through its antioxidant activity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Antioxidant capacity of calendula officinalis flowers extract and prevention of radiation induced oropharyngeal mucositis in patients with head and neck cancers: a randomized controlled clinical study. by Babaee N, Moslemi D, Khalilpour M, Vejdani F, Moghadamnia Y, Bijani A, Baradaran M, Kazemi MT, Khalilpour A, Pouramir M, Moghadamnia AA. (PubMed)
(2) Effect of Calendula officinalis Flower Extract on Acute Phase Proteins, Antioxidant Defense Mechanism and Granuloma Formation During Thermal Burns by Chandran PK, Kuttan R.(PubMed)
(3) Hepato and reno protective action of Calendula officinalis L. flower extract by Preethi KC, Kuttan R.(PubMed)
Antioxidants are stable molecules that inhibit the oxidation induced by free radicals.
Free radicals are unstable and high reactive molecules with a single electron in the outer ring.
In order for them to become stable, free radicals are ready to donate or intercept an electron from other molecules, leading to a chain reaction that cannot be stopped until the electrons on the outer ring are paired or inhibited by antioxidants.
Oxidative stress is a condition caused by either overexpression of free radical or low levels of antioxidant enzymes produced by the host body.
In other words, the unbalanced ratio of the levels of free radicals and antioxidants enzymes is the major cause of the onset of oxidative stress, leading to the damage of lipid, DNA, and protein in the cells of the host.
Although there are many risk factors associated with the development of the condition, some researchers suggested that smoking is one of the preventable and major risks in the induction of the onset of oxidative stress.
Dr. Isik B in the comparison of the risk of oxidative stress in smokers and nonsmokers wrote, "Smoking may enhance oxidative stress not only through the production of reactive oxygen radicals in smoke but also through the weakening of the antioxidant defense systems".
And, ": The serum MDA levels were significantly higher (p < .05) and serum PON1 activities were significantly lower (p < .001) in smokers than in nonsmokers".
Where serum malondialdehyde (MDA) is an oxidative stress marker and paraoxonase (PON1) is an HDL-associated enzyme that protects the HDL against oxidation.
Calendula is also known as pot marigold, annual or perennial herbaceous plants of about 12–20 species of genus Calendula, belonging to the family Asteraceae, native to Southern Europe.
The herbal medicine has been used in herbal medicine as spasmolytic, spasmogenic, inflammatory effects and for the treatment of abdominal cramps, wound healing, skin diseases, colitis, constipation, etc.
Besides major chemical constituents of triterpenoids, flavonoids, coumarines, quinones, volatile oil, carotenoids, and amino acids, the herb also contains loliolide (calendin), calendulin and n-paraffins.
Researchers on finding herbal medicine which process a high amount of antioxidants examined the
Calendula officinalis flower extract effects against experimentally induced thermal burns made on the shaven back of the rats under anesthesia in rats.
The animals then are treated orally with different doses of the flower extracts (20 mg, 100 mg, and 200 mg/kg body weight).
Injection of the extracts showed significant improvement in healing when compared with the control untreated animals.
The wound healing is observed by the speeding up through the increase of the concentration of collagen contents in the treated group.
The acute phase proteins associated with the oxidative activity was increased due to burning were found to be decreased significantly in 200 mg/kg body weight extract-treated animals.
The antioxidant defense mechanism decreased in the liver during burn injury, was found to be enhanced in treated animals.
The lipid peroxidation was significantly lowered in the treated group, accompanied by a decrease of the tissue damage marker compared to control animals.
Furthermore, in the investigation of the Flower extract of C. officinalis L. protective effect against CCl4 induced acute hepatotoxicity and cisplatin-induced nephrotoxicity, pretreatment of the flower extract at 100 and 250 mg/kg body weight exerted a significant reduction of the tissue and oxidative stress markers compared to the untreated group.
The extract displayed a liver protective effect observed by the decreased levels of lipid peroxidation the marker of membrane damage and the total bilirubin content in the liver.
Moreover, the herbal extract also demonstrated kidney protective effects observed by the reduced levels of the kidney function markers, urea, and creatinine which were significantly increased in cisplatin-treated animals.
Additionally, the cisplatin-induced myelosuppression was ameliorated by the extract pretreatment, by enhancing the levels of antioxidant enzymes, such as superoxide dismutase and catalase and glutathione.
Dr. Preethi KC, the lead scientist wrote in the final report, "Possible mechanism of action of the flower extract may be due to its antioxidant activity and reduction of oxygen radicals".
Taken altogether, herbal Calendula may be considered a functional remedy for the protection of our body against disease associated with oxidative stress, through its antioxidant activity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Antioxidant capacity of calendula officinalis flowers extract and prevention of radiation induced oropharyngeal mucositis in patients with head and neck cancers: a randomized controlled clinical study. by Babaee N, Moslemi D, Khalilpour M, Vejdani F, Moghadamnia Y, Bijani A, Baradaran M, Kazemi MT, Khalilpour A, Pouramir M, Moghadamnia AA. (PubMed)
(2) Effect of Calendula officinalis Flower Extract on Acute Phase Proteins, Antioxidant Defense Mechanism and Granuloma Formation During Thermal Burns by Chandran PK, Kuttan R.(PubMed)
(3) Hepato and reno protective action of Calendula officinalis L. flower extract by Preethi KC, Kuttan R.(PubMed)
Wednesday, January 8, 2020
Andrographis paniculata, The Herbal Remedy Which Protects Neurons Integrity Against Onset of Alzheimer's disease
Alzheimer's disease (AD) is a chronic neurodegenerative disease that is irreversible and starts slowly and worsens over time, affecting patients thinking ability and memory, correlated with major reductions of neurons to the respective target areas. The disease is named after German physician Alois Alzheimer's.
Some researchers suggested that the disease is caused by a prolonged period of plaques excessive accumulation in the brain cells, leading to brain cells degeneration and death.
People with Alzheimer's disease may experience the decline of cognitive and functional abilities, change of motions and moods and behavior, particularly, in reducing the quality of life due to disability in physical activity.
According to the statistic provided by the Alzheimer.Net, approximately, 44 million people have Alzheimer’s or related dementia worldwide. The disease is most common in North America and Western Europe.
Alzheimer’s disease is the 6th leading cause of death in the United States.
In the US, Alzheimer’s cost the United States taxpayer $259 billion in 2017.
Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka.
The herb has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,...
According to the joint study lead by the Pontificia Universidad Catolica de Chile, oral administrated natural product (Andrographolide, ANDRO) isolated from Andrographis paniculata in species Octodon degus (degu) exhibited the recovery of spatial memory and learning performance, through regulated phosphorylated tau protein and amyloid-beta aggregate maturation in cell survival in inducing Alzheimer's disease.
Dr., the lead author in the joint study said, "(Andrographolide, ANDRO) inhibited) neural damage associated with aging processes and the behavioral and neuropathological hallmarks of aging-related diseases such as AD"
Additionally, Andrographolide also displayed the inhibitory activity against forming of amyloid-beta (Aβ)42 through suppression of NF-κB, a protein that regulates cell survival and function of microglia in activated response to brain damage and immunological stimuli together with the reduction in the production of pro-inflammatory cytokines.
In an animal study, mice treated with Andrographolide increased neural progenitor cell proliferation and decreased the number of immature neurons in the hippocampus, compared to age-matched control mice.
Moreover, ANDRO increased the number of newborn dentate granule neurons in various parts of the brain.
The study also found that the efficacy that reduces symptoms and protects against the early onset of AD is the result of the stimulation of neurogenesis in the hippocampus.
Taking together, Andrographis paniculata is surely consisted of a therapeutic potential to protect the development of Alzheimer's disease through various mechanisms, however, intake of large amount daily should be taken with care.
However, additional data collection on large example size and multi centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of Andrographis paniculata anti-Alzheimer's disease possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Andrographolide Activates Keap1/Nrf2/ARE/HO-1 Pathway in HT22 Cells and Suppresses Microglial Activation by Aβ42 through Nrf2-Related Inflammatory Response by Seo JY1, Pyo E1, An JP1, Kim J1, Sung SH1, Oh WK1.(PubMed)
(2) Andrographolide recovers cognitive impairment in a natural model of Alzheimer's disease (Octodon degus) by Rivera DS1, Lindsay C2, Codocedo JF2, Morel I3, Pinto C2, Cisternas P4, Bozinovic F5, Inestrosa NC6.(PubMed)
(3) Andrographolide Stimulates Neurogenesis in the Adult Hippocampus by Varela-Nallar L1, Arredondo SB1, Tapia-Rojas C2, Hancke J3, Inestrosa NC4.(PubMed)
Some researchers suggested that the disease is caused by a prolonged period of plaques excessive accumulation in the brain cells, leading to brain cells degeneration and death.
People with Alzheimer's disease may experience the decline of cognitive and functional abilities, change of motions and moods and behavior, particularly, in reducing the quality of life due to disability in physical activity.
According to the statistic provided by the Alzheimer.Net, approximately, 44 million people have Alzheimer’s or related dementia worldwide. The disease is most common in North America and Western Europe.
Alzheimer’s disease is the 6th leading cause of death in the United States.
In the US, Alzheimer’s cost the United States taxpayer $259 billion in 2017.
Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka.
The herb has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,...
According to the joint study lead by the Pontificia Universidad Catolica de Chile, oral administrated natural product (Andrographolide, ANDRO) isolated from Andrographis paniculata in species Octodon degus (degu) exhibited the recovery of spatial memory and learning performance, through regulated phosphorylated tau protein and amyloid-beta aggregate maturation in cell survival in inducing Alzheimer's disease.
Dr., the lead author in the joint study said, "(Andrographolide, ANDRO) inhibited) neural damage associated with aging processes and the behavioral and neuropathological hallmarks of aging-related diseases such as AD"
Additionally, Andrographolide also displayed the inhibitory activity against forming of amyloid-beta (Aβ)42 through suppression of NF-κB, a protein that regulates cell survival and function of microglia in activated response to brain damage and immunological stimuli together with the reduction in the production of pro-inflammatory cytokines.
In an animal study, mice treated with Andrographolide increased neural progenitor cell proliferation and decreased the number of immature neurons in the hippocampus, compared to age-matched control mice.
Moreover, ANDRO increased the number of newborn dentate granule neurons in various parts of the brain.
The study also found that the efficacy that reduces symptoms and protects against the early onset of AD is the result of the stimulation of neurogenesis in the hippocampus.
Taking together, Andrographis paniculata is surely consisted of a therapeutic potential to protect the development of Alzheimer's disease through various mechanisms, however, intake of large amount daily should be taken with care.
However, additional data collection on large example size and multi centers studies performed with human consumption of the whole food during the course of the disease will be necessary to complete the picture of Andrographis paniculata anti-Alzheimer's disease possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Andrographolide Activates Keap1/Nrf2/ARE/HO-1 Pathway in HT22 Cells and Suppresses Microglial Activation by Aβ42 through Nrf2-Related Inflammatory Response by Seo JY1, Pyo E1, An JP1, Kim J1, Sung SH1, Oh WK1.(PubMed)
(2) Andrographolide recovers cognitive impairment in a natural model of Alzheimer's disease (Octodon degus) by Rivera DS1, Lindsay C2, Codocedo JF2, Morel I3, Pinto C2, Cisternas P4, Bozinovic F5, Inestrosa NC6.(PubMed)
(3) Andrographolide Stimulates Neurogenesis in the Adult Hippocampus by Varela-Nallar L1, Arredondo SB1, Tapia-Rojas C2, Hancke J3, Inestrosa NC4.(PubMed)
Herbal Aloe vera, the Anti Primary Glioblastoma Functional Remedy
Aloe vera may process a strong implication in reducing the risk of primary glioblastoma, according to studies.
Primary glioblastoma is considered the most aggressive cancer that begins within the brain. Cancer may arise de novo, meaning they begin as a Grade IV tumor with no evidence.
According to the statistic, the median survival time of primary glioblastoma is approximately 3 months without medical treatment. Glioblastomas represent about 15% of all primary brain tumors.
Due to the rapid growth of the tumor, patients diagnosed with primary glioblastoma experience brain swelling and increased brain pressure, leading to symptoms of nausea, vomiting, and severe headaches and localized symptoms depending on the location of the tumor.
Radiation and chemotherapy are the most common forms of treatment for patients with glioblastoma particularly, in a tumor that cannot be removed with surgery.
Increased age, and genetic preposition are the 2 most common risk factors of the diseases. Dr. Athanassios P. Kyritsis, in the concern of the rapid progression of glioblastoma, wrote, "Scientific evidence during the last few years has revealed several constitutive genetic abnormalities that may influence glioma formation".
And, "These germline abnormalities are manifested as either gene polymorphisms or hemizygous mutations of key regulatory genes that are involved either in DNA repair or in apoptosis".
Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits.
The herbal plant has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated cholesterol, etc.
Researchers on the finding a natural compound for the treatment of cancer examined the anti-brain cancer effect of Aloe-emodin isolated from the leaves of Aloe vera in human U87 malignant glioma cells.
Injection of Aloe-emodin exerted a significant apoptotic activity and induced proliferation in a time- and dose-dependent.
The percentage of viable U87 cells was also deceased substantial via the induction of apoptosis.
The formation of apoptotic bodies was observed by the confocal microscope by Annexin V-FITC/PI staining.
Aloe-emodin inhibits the human U87 malignant glioma cells, was attributed to the arrested the cell cycle in the S phase and promoted the loss of mitochondrial membrane potential in U87 cells.
In order to reveal the inhibitory efficacy mechanisms of Aloe-emodin against human U87 malignant glioma cells, researchers at the University of South Florida, Tampa, examined the effects of the bioactive compound through the aspects of the cell cycle, cell proliferation and protein kinase C (PKC) during glioma growth and development.
In cell cycle arrest, according to the flow cytometry assay, Aloe-emodin delayed the number of cells entering and exiting the DNA synthesis (S) phase in both SVG and U-373MG cells, a strong indication that Aloe-emodin may inhibit S phase progression.
In cell viability assay, SVG and U-373MG glioma cells were highly sensitive to the application of Aloe-emodin.
Furthermore, injection of Aloe-emodin-induced decreased proliferation, sustained at 48-96 hours.
Exposure of SVG and U-373MG glioma cells to aloe-emodin suppressed PKC activity in the promotion of cancer cell proliferation by reduced the protein content of most of the PKC enzymes.
Moreover, Aloe-emodin inhibited cancer growth was also associated with the activation of a protein in programming cell death.
Taken altogether, herbal Aloe vera processed a major bioactive compound Aloe-emodin may be considered a functional remedy for the prevention and combined with primary therapy for the treatment of brain cancer, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Enhanced induction of cell cycle arrest and apoptosis via the mitochondrial membrane potential disruption in human U87 malignant glioma cells by aloe emodin by Ismail S, Haris K, Abdul Ghani AR, Abdullah JM, Johan MF, Mohamed Yusoff AA.(PubMed)
(2) Aloe-emodin modulates PKC isozymes, inhibits proliferation, and induces apoptosis in U-373MG glioma cells by Acevedo-Duncan M, Russell C, Patel S, Patel R.(PubMed)
(3) Inherited predisposition to glioma by Athanassios P. Kyritsis, Melissa L. Bondy, Jasti S. Rao, and Chrissa Sioka. (PMC)
Primary glioblastoma is considered the most aggressive cancer that begins within the brain. Cancer may arise de novo, meaning they begin as a Grade IV tumor with no evidence.
According to the statistic, the median survival time of primary glioblastoma is approximately 3 months without medical treatment. Glioblastomas represent about 15% of all primary brain tumors.
Due to the rapid growth of the tumor, patients diagnosed with primary glioblastoma experience brain swelling and increased brain pressure, leading to symptoms of nausea, vomiting, and severe headaches and localized symptoms depending on the location of the tumor.
Radiation and chemotherapy are the most common forms of treatment for patients with glioblastoma particularly, in a tumor that cannot be removed with surgery.
Increased age, and genetic preposition are the 2 most common risk factors of the diseases. Dr. Athanassios P. Kyritsis, in the concern of the rapid progression of glioblastoma, wrote, "Scientific evidence during the last few years has revealed several constitutive genetic abnormalities that may influence glioma formation".
And, "These germline abnormalities are manifested as either gene polymorphisms or hemizygous mutations of key regulatory genes that are involved either in DNA repair or in apoptosis".
Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits.
The herbal plant has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated cholesterol, etc.
Researchers on the finding a natural compound for the treatment of cancer examined the anti-brain cancer effect of Aloe-emodin isolated from the leaves of Aloe vera in human U87 malignant glioma cells.
Injection of Aloe-emodin exerted a significant apoptotic activity and induced proliferation in a time- and dose-dependent.
The percentage of viable U87 cells was also deceased substantial via the induction of apoptosis.
The formation of apoptotic bodies was observed by the confocal microscope by Annexin V-FITC/PI staining.
Aloe-emodin inhibits the human U87 malignant glioma cells, was attributed to the arrested the cell cycle in the S phase and promoted the loss of mitochondrial membrane potential in U87 cells.
In order to reveal the inhibitory efficacy mechanisms of Aloe-emodin against human U87 malignant glioma cells, researchers at the University of South Florida, Tampa, examined the effects of the bioactive compound through the aspects of the cell cycle, cell proliferation and protein kinase C (PKC) during glioma growth and development.
In cell cycle arrest, according to the flow cytometry assay, Aloe-emodin delayed the number of cells entering and exiting the DNA synthesis (S) phase in both SVG and U-373MG cells, a strong indication that Aloe-emodin may inhibit S phase progression.
In cell viability assay, SVG and U-373MG glioma cells were highly sensitive to the application of Aloe-emodin.
Furthermore, injection of Aloe-emodin-induced decreased proliferation, sustained at 48-96 hours.
Exposure of SVG and U-373MG glioma cells to aloe-emodin suppressed PKC activity in the promotion of cancer cell proliferation by reduced the protein content of most of the PKC enzymes.
Moreover, Aloe-emodin inhibited cancer growth was also associated with the activation of a protein in programming cell death.
Taken altogether, herbal Aloe vera processed a major bioactive compound Aloe-emodin may be considered a functional remedy for the prevention and combined with primary therapy for the treatment of brain cancer, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Enhanced induction of cell cycle arrest and apoptosis via the mitochondrial membrane potential disruption in human U87 malignant glioma cells by aloe emodin by Ismail S, Haris K, Abdul Ghani AR, Abdullah JM, Johan MF, Mohamed Yusoff AA.(PubMed)
(2) Aloe-emodin modulates PKC isozymes, inhibits proliferation, and induces apoptosis in U-373MG glioma cells by Acevedo-Duncan M, Russell C, Patel S, Patel R.(PubMed)
(3) Inherited predisposition to glioma by Athanassios P. Kyritsis, Melissa L. Bondy, Jasti S. Rao, and Chrissa Sioka. (PMC)
Herbal Artichoke Normalizes the Levels of Serum Cholesterol in Vivo and Human Study
Hyperlipidemia is a chronic condition of abnormally high blood cholesterol in the bloodstream.
Cholesterol is a waxy substance produced by the liver or dietary intake that processes a significant activity in the improvement of the digestive system by breaking down food, in the production of vitamin D and steroid hormone, particularly in the building of strong cell membranes.
There are 2 types of cholesterol. The low-density lipoprotein is also known as bad cholesterol which performs the aforementioned activity in the right levels and high-density lipoprotein which returns cholesterol back to the liver for reuse.
However, overexpression of cholesterol can cause plaque building up on the arterial wall, leading to arterial narrowing, wall stiffness, and hardening, some major causes of heart disease and stroke.
According to the free radical theory, overexpression of cholesterol also increases the risk of lipid peroxidation, leading to the onset of various diseases.
Dr, Yagi K, at the Institute of Applied Biochemistry in the analysis of the lipid peroxides and human diseases, said, "The lipid peroxidation (LPO) products are highly reactive and display marked biological effects, which, depending upon their concentration, cause selective alterations in cell signaling, protein and DNA damage, and cytotoxicity"
And. "Increased formation of lipid peroxides and aldehydes has been observed in atherosclerosis, ischemia-reperfusion, heart failure, Alzheimer’s disease, rheumatic arthritis, cancer, and other immunological disorders".
The findings clearly suggested that your risk of diseases is increased substantially if you have abnormally high blood cholesterol.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine for as liver protective and detoxified agents, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on the finding a natural therapeutics for the treatment of abnormal blood cholesterol, researchers examined artichoke leaf extract (ALE) activity in lowering the plasma total and non-HDL cholesterol by increasing fecal excretion of neutral bile acids and sterols.
The study included 64 Golden Syrian hamsters (8 weeks old) fed control diet or a similar diet containing ALE (4.5 g/kg diet) for 6 weeks.
There were no significant changes for total cholesterol, HDL, non-HDL cholesterol triglycerides or fecal neutral sterols and bile acids were after 21 days for ALE-fed animals compared with controls.
However, ALE-fed male hamsters had significantly lower total cholesterol (15%), non-HDL cholesterol (30%) and triglycerides (22%) and female hamsters fed ALE showed reductions of 15% for total cholesterol, 29% for non-HDL cholesterol and 29% for triglycerides compared with controls after 42 days.
Furthermore, the total neutral sterol and bile acid concentrations also increased significantly by 50% and 53% in fecal samples of ALE fed males, and 82.4% and 25% in ALE fed females compared with controls.
Dr. Qiang Z, after taking into account other factors, said, "he ALE lowered hamster plasma cholesterol levels by a mechanism involving the greater excretion of fecal bile acids and neutral sterols after feeding for 42 days".
In order to reveal more information about artichoke anti-high blood cholesterol property, researchers evaluated the effects of artichoke leaf extract (ALE) supplementation (250 mg, 2 b.i.d.) on the lipid pattern,
The randomized, double-blind, placebo-controlled clinical trial included 92 overweight subjects with primary mild hypercholesterolemia for 8 weeks.
46 subjects were randomized to supplementation (age: 54.2 ± 6.6 years, body mass index (BMI): 25.8 ± 3.9 kg/m(2), male/female: 20/26) and 46 subjects to placebo (age: 53.8 ± 9.0 years, BMI: 24.8 ± 1.6 kg/m(2), male/female: 21/25).
Artichoke leaf extract (ALE) supplementation was associated with a significant increase in mean high-density lipoprotein (HDL)-cholesterol (p < 0.001) and in mean change in HDL-cholesterol (HDL-C) (p = 0.004).
Moreover, ALE also significantly decreased the mean change in total cholesterol (p = 0.033), low-density lipoprotein (LDL)-cholesterol (p < 0.001), total cholesterol/HDL ratio (p < 0.001) and LDL/HDL ratio (p < 0.001) comapred to control.
The findings clearly supported the use of artichoke leaf extract ALE for the treatment of patients with mild high blood cholesterol.
Taken altogether, artichoke may be considered a functional formula for the treatment of patients with high blood cholesterol with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Artichoke extract lowered plasma cholesterol and increased fecal bile acids in Golden Syrian hamsters by Qiang Z1, Lee SO, Ye Z, Wu X, Hendrich S.(PubMed)
(2) Beneficial effects of artichoke leaf extract supplementation on increasing HDL-cholesterol in subjects with primary mild hypercholesterolaemia: a double-blind, randomized, placebo-controlled trial by Rondanelli M1, Giacosa A, Opizzi A, Faliva MA, Sala P, Perna S, Riva A, Morazzoni P, Bombardelli E. (PubMed)
(3) Lipid Peroxidation Products in Human Health and Disease by Kota V. Ramana,1 Sanjay Srivastava,2 and Sharad S. Singha. (Hindawi)
Cholesterol is a waxy substance produced by the liver or dietary intake that processes a significant activity in the improvement of the digestive system by breaking down food, in the production of vitamin D and steroid hormone, particularly in the building of strong cell membranes.
There are 2 types of cholesterol. The low-density lipoprotein is also known as bad cholesterol which performs the aforementioned activity in the right levels and high-density lipoprotein which returns cholesterol back to the liver for reuse.
However, overexpression of cholesterol can cause plaque building up on the arterial wall, leading to arterial narrowing, wall stiffness, and hardening, some major causes of heart disease and stroke.
According to the free radical theory, overexpression of cholesterol also increases the risk of lipid peroxidation, leading to the onset of various diseases.
Dr, Yagi K, at the Institute of Applied Biochemistry in the analysis of the lipid peroxides and human diseases, said, "The lipid peroxidation (LPO) products are highly reactive and display marked biological effects, which, depending upon their concentration, cause selective alterations in cell signaling, protein and DNA damage, and cytotoxicity"
And. "Increased formation of lipid peroxides and aldehydes has been observed in atherosclerosis, ischemia-reperfusion, heart failure, Alzheimer’s disease, rheumatic arthritis, cancer, and other immunological disorders".
The findings clearly suggested that your risk of diseases is increased substantially if you have abnormally high blood cholesterol.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine for as liver protective and detoxified agents, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on the finding a natural therapeutics for the treatment of abnormal blood cholesterol, researchers examined artichoke leaf extract (ALE) activity in lowering the plasma total and non-HDL cholesterol by increasing fecal excretion of neutral bile acids and sterols.
The study included 64 Golden Syrian hamsters (8 weeks old) fed control diet or a similar diet containing ALE (4.5 g/kg diet) for 6 weeks.
There were no significant changes for total cholesterol, HDL, non-HDL cholesterol triglycerides or fecal neutral sterols and bile acids were after 21 days for ALE-fed animals compared with controls.
However, ALE-fed male hamsters had significantly lower total cholesterol (15%), non-HDL cholesterol (30%) and triglycerides (22%) and female hamsters fed ALE showed reductions of 15% for total cholesterol, 29% for non-HDL cholesterol and 29% for triglycerides compared with controls after 42 days.
Furthermore, the total neutral sterol and bile acid concentrations also increased significantly by 50% and 53% in fecal samples of ALE fed males, and 82.4% and 25% in ALE fed females compared with controls.
Dr. Qiang Z, after taking into account other factors, said, "he ALE lowered hamster plasma cholesterol levels by a mechanism involving the greater excretion of fecal bile acids and neutral sterols after feeding for 42 days".
In order to reveal more information about artichoke anti-high blood cholesterol property, researchers evaluated the effects of artichoke leaf extract (ALE) supplementation (250 mg, 2 b.i.d.) on the lipid pattern,
The randomized, double-blind, placebo-controlled clinical trial included 92 overweight subjects with primary mild hypercholesterolemia for 8 weeks.
46 subjects were randomized to supplementation (age: 54.2 ± 6.6 years, body mass index (BMI): 25.8 ± 3.9 kg/m(2), male/female: 20/26) and 46 subjects to placebo (age: 53.8 ± 9.0 years, BMI: 24.8 ± 1.6 kg/m(2), male/female: 21/25).
Artichoke leaf extract (ALE) supplementation was associated with a significant increase in mean high-density lipoprotein (HDL)-cholesterol (p < 0.001) and in mean change in HDL-cholesterol (HDL-C) (p = 0.004).
Moreover, ALE also significantly decreased the mean change in total cholesterol (p = 0.033), low-density lipoprotein (LDL)-cholesterol (p < 0.001), total cholesterol/HDL ratio (p < 0.001) and LDL/HDL ratio (p < 0.001) comapred to control.
The findings clearly supported the use of artichoke leaf extract ALE for the treatment of patients with mild high blood cholesterol.
Taken altogether, artichoke may be considered a functional formula for the treatment of patients with high blood cholesterol with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Artichoke extract lowered plasma cholesterol and increased fecal bile acids in Golden Syrian hamsters by Qiang Z1, Lee SO, Ye Z, Wu X, Hendrich S.(PubMed)
(2) Beneficial effects of artichoke leaf extract supplementation on increasing HDL-cholesterol in subjects with primary mild hypercholesterolaemia: a double-blind, randomized, placebo-controlled trial by Rondanelli M1, Giacosa A, Opizzi A, Faliva MA, Sala P, Perna S, Riva A, Morazzoni P, Bombardelli E. (PubMed)
(3) Lipid Peroxidation Products in Human Health and Disease by Kota V. Ramana,1 Sanjay Srivastava,2 and Sharad S. Singha. (Hindawi)
Tuesday, January 7, 2020
Andrographis in Reduced Risk and Treatment of Leukemia
Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka. It has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,...
A renowned institute study suggested that andrographolide, a major compound isolated from Andrographis may consist potentially therapeutic effects in reduced risk and controlling the progression of leukemia.
Leukemia is the condition of abnormal increase of white blood cells produced by the bone marrow and/or the lymphatic system. Depending on the malignant granulocytes or lymphocytes, leukemia is classified into myelogenous or lymphoblastic leukemia.
According to the joint study lead by the Jining No 1 People's Hospital, andrographolide (Andro) showed to possess antitumor activities against T-cell acute lymphoblastic leukemia (T-ALL) through induced cytotoxicity in tumor and cell apoptosis.
10 μg/mL Andro could significantly induce tumor cells' death, depending on the inhibition of PI3K/AKT pathway in regulating the cell cycle and increased expression of cancer cell apoptosis.
The flavonoid, chemical compounds isolated from the aerial parts of Andrographis paniculata also exhibited antiproliferative effects against human leukemia HL-60 cells with IC50 of 3.50 μM.
Furthermore, the study in the evaluation of the potential effect of andrographolide against three acute promyelocytic leukemia cell line models (HL-60, NB4 and all-trans retinoic acid (ATRA)-resistant NB4-R2, andrographolide was 2- and 3-fold more active in inhibiting the growth of HL-60 and NB4-R2 cells compared with NB4 cells, through cell differentiating activity via a retinoic acid receptor-independent pathway.
In fact, according to Dr. Manikam SD, the lead researcher, andrographolide and its derivatives, apparently demonstrated a novel cell differentiating mechanism with the ability to induce apoptosis.
There is no doubt that Andrographis with a novel mechanism of drug action may be a new candidated therapy for reduced risk and treatment of Leukemia, but a large amount of intake should be taken with care.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Andrographolide inhibits growth of human T-cell acute lymphoblastic leukemiaJurkat cells by downregulation of PI3K/AKT and upregulation of p38 MAPK pathways by Yang T, Yao S, Zhang X, Guo Y.(PubMed)
(2) A new flavonoid from the aerial parts of Andrographis paniculata by Chen LX1, He H, Xia GY, Zhou KL, Qiu F.(PubMed)
(3) Andrographolide inhibits growth of acute promyelocytic leukaemia cells by inducing retinoic acid receptor-independent cell differentiation and apoptosis by Manikam SD1, Stanslas J.(PubMed)
A renowned institute study suggested that andrographolide, a major compound isolated from Andrographis may consist potentially therapeutic effects in reduced risk and controlling the progression of leukemia.
Leukemia is the condition of abnormal increase of white blood cells produced by the bone marrow and/or the lymphatic system. Depending on the malignant granulocytes or lymphocytes, leukemia is classified into myelogenous or lymphoblastic leukemia.
According to the joint study lead by the Jining No 1 People's Hospital, andrographolide (Andro) showed to possess antitumor activities against T-cell acute lymphoblastic leukemia (T-ALL) through induced cytotoxicity in tumor and cell apoptosis.
10 μg/mL Andro could significantly induce tumor cells' death, depending on the inhibition of PI3K/AKT pathway in regulating the cell cycle and increased expression of cancer cell apoptosis.
The flavonoid, chemical compounds isolated from the aerial parts of Andrographis paniculata also exhibited antiproliferative effects against human leukemia HL-60 cells with IC50 of 3.50 μM.
Furthermore, the study in the evaluation of the potential effect of andrographolide against three acute promyelocytic leukemia cell line models (HL-60, NB4 and all-trans retinoic acid (ATRA)-resistant NB4-R2, andrographolide was 2- and 3-fold more active in inhibiting the growth of HL-60 and NB4-R2 cells compared with NB4 cells, through cell differentiating activity via a retinoic acid receptor-independent pathway.
In fact, according to Dr. Manikam SD, the lead researcher, andrographolide and its derivatives, apparently demonstrated a novel cell differentiating mechanism with the ability to induce apoptosis.
There is no doubt that Andrographis with a novel mechanism of drug action may be a new candidated therapy for reduced risk and treatment of Leukemia, but a large amount of intake should be taken with care.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Andrographolide inhibits growth of human T-cell acute lymphoblastic leukemiaJurkat cells by downregulation of PI3K/AKT and upregulation of p38 MAPK pathways by Yang T, Yao S, Zhang X, Guo Y.(PubMed)
(2) A new flavonoid from the aerial parts of Andrographis paniculata by Chen LX1, He H, Xia GY, Zhou KL, Qiu F.(PubMed)
(3) Andrographolide inhibits growth of acute promyelocytic leukaemia cells by inducing retinoic acid receptor-independent cell differentiation and apoptosis by Manikam SD1, Stanslas J.(PubMed)
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