Andrographis in Reduced Risk and Treatment of Leukemia

Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka. It has been used in traditional Siddha and Ayurvedic in treating the common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,...

A renowned institute study suggested that andrographolide, a major compound isolated from Andrographis may consist potentially therapeutic effects in reduced risk and controlling the progression of leukemia.

Leukemia is the condition of abnormal increase of white blood cells produced by the bone marrow and/or the lymphatic system. Depending on the malignant granulocytes or lymphocytes, leukemia is classified into myelogenous or lymphoblastic leukemia.



According to the joint study lead by the Jining No 1 People's Hospital, andrographolide (Andro) showed to possess antitumor activities against T-cell acute lymphoblastic leukemia (T-ALL) through induced cytotoxicity in tumor and cell apoptosis.


10 μg/mL Andro could significantly induce tumor cells' death, depending on the inhibition of PI3K/AKT pathway in regulating the cell cycle and increased expression of cancer cell apoptosis.



The flavonoid, chemical compounds isolated from the aerial parts of Andrographis paniculata also exhibited antiproliferative effects against human leukemia HL-60 cells with IC50 of 3.50 μM.




Furthermore, the study in the evaluation of the potential effect of andrographolide against three acute promyelocytic leukemia cell line models (HL-60, NB4 and all-trans retinoic acid (ATRA)-resistant NB4-R2, andrographolide was 2- and 3-fold more active in inhibiting the growth of HL-60 and NB4-R2 cells compared with NB4 cells, through cell differentiating activity via a retinoic acid receptor-independent pathway.



In fact, according to Dr. Manikam SD, the lead researcher, andrographolide and its derivatives, apparently demonstrated a novel cell differentiating mechanism with the ability to induce apoptosis.

There is no doubt that Andrographis with a novel mechanism of drug action may be a new candidated therapy for reduced risk and treatment of Leukemia, but a large amount of intake should be taken with care.


Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(1) Andrographolide inhibits growth of human T-cell acute lymphoblastic leukemiaJurkat cells by downregulation of PI3K/AKT and upregulation of p38 MAPK pathways by Yang T, Yao S, Zhang X, Guo Y.(PubMed)
(2) A new flavonoid from the aerial parts of Andrographis paniculata by Chen LX1, He H, Xia GY, Zhou KL, Qiu F.(PubMed)
(3) Andrographolide inhibits growth of acute promyelocytic leukaemia cells by inducing retinoic acid receptor-independent cell differentiation and apoptosis by Manikam SD1, Stanslas J.(PubMed)