Diabetes is a chronic condition caused by insufficient insulin entering the bloodstream. Insulin resistance and hyperglycemia are hallmarks of diabetes.
In other words, insulin produced by the pancreas is either blocked by the clogging-up of the insulin receptors by fat and cholesterol or the death of beta cells in the pancreas. In some cases, diabetes can also be associated with autoimmune disease, attacking the beta cells.
There are some major types of diabetes, including the best known, type 1 and 2.
* Type 1 diabetes is associated with a genetic proposition that leads to the immune system to attack insulin-producing cells of the pancreas.
* Type 2 diabetes (acquired diabetes), is a condition caused by either the pancreas doesn't produce enough insulin, or the insulin does not work properly due to dysfunction of the insulin receptors.
In pregnancy, gestational diabetes is a type of diabetes occurred during the second or third trimester of pregnancy. Gestation diabetes goes away after giving birth.
However, omen with gestation diabetes is associated with a substantial risk of diabetic developing sometimes in the future.
Epidemiologically, obesity, an unhealthy lifestyle with physical inactivity are some of the most common risk factor associated with the slow onset of diabetes.
Interestingly, some researchers suggested, night shifts workers accompanied by unhealthy lifestyles are linking to a high risk of type 2 diabetes suggested, " risk of type 2 diabetes is actually higher than simply adding the individual risks associated with unhealthy lifestyle and shift work together, indicating that combining an unhealthy lifestyle with irregular night-time working adds a further risk".
"It is well-established that unhealthy lifestyle behaviors such as smoking, a poor diet, and little exercise, and being overweight or obese increase the risk of type 2 diabetes. Shift work, especially night shift work, has also been associated with a greater risk of type 2 diabetes".
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
With an aim to find a potent compound for the treatment of diabetes, researchers examined the effects of Withania somnifera (WS) on lipid peroxidation (LPO) and pancreas in type 2 diabetic rats.
The study included type 2 diabetes induced by a single intraperitoneal injection of STZ (100 mg/kg) to 2 days old rat pups pretreated by WS.
According to the tested analysis, untreated rats group showed significant levels of lipid peroxidation (LPO) observed by reducing levels of antioxidant enzymes produced by the host including glutathione (GSH) contents and by enzymatic activities of glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST), superoxide dismutase (SOD) and catalase (CAT).
However, injection of WS not only caused a significant decrease in blood glucose and tissue LPO levels caused by the application of STZ but also a significant increase in GSH contents, compared to type 2 diabetic control rats.
Furthermore, antioxidant enzymes reduced in the untreated rat such as GPx, GR, GST, SOD, and CAT were also increased compared to type 2 diabetic control rats.
Most importantly, the significant reduction in the number and size of pancreatic beta-cells in STZ rats was normalized upon the administration of WS, evident from the histopathological examination.
In other words, WS protects the cells in the pancreas against oxidation and maintains the integrity of beta cells in insulin production in type 2 diabetes rats.
Based on the findings, researchers said, "WS has shown strong free radical scavenging activity and helped in improving the non-enzymatic and enzymatic antioxidants in type 2 diabetic rats".
Taken altogether, Ashwagandha WS may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of type 2 diabetes, pending to the results of large example size and multicenter study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effect of Withania somnifera against oxidative stress and pancreatic beta-cell damage in type 2 diabetic rats by Anwer T1, Sharma M, Pillai KK, Khan G. (PubMed)
(2) Oral supplementation of standardized extract of Withania somnifera protects against diabetes-induced testicular oxidative impairments in prepubertal rats by Kyathanahalli CN1, Manjunath MJ, Muralidhara. (PubMed)
(3) Night shifts and an unhealthy lifestyle linked to high risk of type 2 diabetes by BMJ
Wednesday, February 5, 2020
Herbal Artichoke Regulates Insulinemic Response
Insulin response is a process of your body that reacts to the dietary intake.
Insulin produced by the pancreas is a hormone that binds the insulin receptors in the promotion of cells of the intestines to convert glucose to energy for the body's needs.
Acute insulin response used as the predictor of types 2 diabetes by diagnosed both normal fasting and 2-h plasma glucose concentrations.
Compared to a healthy individual with normal insulin response, most patients of prediabetes and diabetes have elevated fasting and 2 hours of plasma glucose concentration.
There are many risk factors associated with the abnormal insulinemic response. However, some researchers suggested that the gradual dying of the beta cells of pancreas and insulin receptors sites clogging-up by cholesterol are 2 of the major causes that affect insulin expression.
Some researchers suggested that abnormal insulin response may be correlated to the widespread of obesity that leads to insulin resistance in the Western world.
Dr. Olga T. Hardy, in the evaluation of the causes of insulin resistance underlying obesity wrote,
"The association between obesity and insulin resistance is an area of much interest and enormous public health impact".
And, "Visceral adiposity is correlated with the accumulation of excess lipid in the liver and results in cell-autonomous impairment in insulin signaling. Visceral adipose tissue is also prone to inflammation and inflammatory cytokine production, which also contribute to impairment in insulin signaling".
The results strongly suggested if you are obese, your risk of insulin resistance increased substantially compared to overweight or healthy weight individuals.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on finding a potential natural ingredient for the modulation of insulinemic response, researchers investigate the impact of the supplementation of a pre-biotic compound [Jerusalem artichoke meal (JAM)] on the glycaemic and insulinemic response in healthy, non-obese warm-blooded horses.
The study included 6 adult mares fed with crushed oat grains (1 g starch/kg bwt per day) and meadow hay (2 kg/100 kg bwt per day) together with either 0.15 g fructooligosaccharides and inulin (FOS+INU)/kg bwt per day via commercial JAM or maize cob meal without grains as control (CON) in 2 × 3-week periods according to a crossover design.
According to the sample collected at the postprandial (PP) time points (-60, 0, 30, 60, 90, 120, 180, 240 and 300 min), and the plasma glucose and serum insulin levels, JAM vs. CON did not change the PP peak of glucose or insulin (glucose: 6.3 ± 0.40 vs. 7.0 ± 0.87 mmol/l.
However, following JAM feeding, glucose and insulin levels declined more rapidly until 240 min PP compared to animal fed with CON.
The finding suggested that JAM exerted a significant effect on postprandial (PP) glucose and insulin levels on and after the time points of 240 min.
Furthermore, in order to reveal more information JA insulinemic response, researchers compared the Jerusalem artichoke (Helianthus tuberosus Linne, HTL) and chungkookjang (CKJ; fermented soybeans) in energy and glucose metabolism.
The study included rats divided into partially pancreatectomized (Px) diabetic rats, and sham-operated non-diabetic control rats and all fed high-fat diets. Additionally, diabetic rats were subdivided into an untreated diabetic control group and those fed with 5% HTL, 5% CKJ or 5% HTL+5% CKJ for 8 weeks. HTL+CKJ treatment reduced visceral fat without modulating energy intake compared to diabetic control.
According to the hyperinsulinemic-euglycemic assay, rats treated HTL, HTL+CKJ showed an improvement in glucose tolerance, compared to the diabetic normal-control group.
CKJ and CKJ+HTL but not HTL, injection groups increased first and second phase insulin secretion compared to that of diabetic-control.
Moreover, the glucose infusion rates (mg/kg bw/min) and hepatic insulin sensitivity were increased and CKJ+HTL (13.5), but not HTL (9.4) or CKJ (9.5) alone, and HTL and CKJ+ HTL decreased hepatic glucose compared to diabetic control.
Dr. Yang HJ, the lead scientist wrote in the final report, "HTL and CKJ enhanced glucose tolerance in different manners, and exhibited partially additive and complementary effects by reversing insulin resistance and enhancing β-cell function in diabetic rats".
Taken altogether, artichoke used alone or combined with another herbal remedy may be considered functional food for the enhancement of insulinemic response against the onset of diabetes, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Glycaemic and insulinaemic responses of adult healthy warm-blooded mares following feeding with Jerusalem artichoke meal by Glatter M1, Bochnia M1, Goetz F1, Gottschalk J2, Koeller G3, Mielenz N4, Hillegeist D5, Greef JM5, Einspanier A2, Zeyner A. (PubMed)
(2) Jerusalem artichoke and chungkookjang additively improve insulin secretion and sensitivity in diabetic rats by Yang HJ1, Kwon DY, Kim MJ, Kang S, Kim DS, Park S. (PubMed)
(3) What causes the insulin resistance underlying obesity? by Olga T. Hardy, Michael P. Czech, and Silvia Corvera. (PMC)
Insulin produced by the pancreas is a hormone that binds the insulin receptors in the promotion of cells of the intestines to convert glucose to energy for the body's needs.
Acute insulin response used as the predictor of types 2 diabetes by diagnosed both normal fasting and 2-h plasma glucose concentrations.
Compared to a healthy individual with normal insulin response, most patients of prediabetes and diabetes have elevated fasting and 2 hours of plasma glucose concentration.
There are many risk factors associated with the abnormal insulinemic response. However, some researchers suggested that the gradual dying of the beta cells of pancreas and insulin receptors sites clogging-up by cholesterol are 2 of the major causes that affect insulin expression.
Some researchers suggested that abnormal insulin response may be correlated to the widespread of obesity that leads to insulin resistance in the Western world.
Dr. Olga T. Hardy, in the evaluation of the causes of insulin resistance underlying obesity wrote,
"The association between obesity and insulin resistance is an area of much interest and enormous public health impact".
And, "Visceral adiposity is correlated with the accumulation of excess lipid in the liver and results in cell-autonomous impairment in insulin signaling. Visceral adipose tissue is also prone to inflammation and inflammatory cytokine production, which also contribute to impairment in insulin signaling".
The results strongly suggested if you are obese, your risk of insulin resistance increased substantially compared to overweight or healthy weight individuals.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on finding a potential natural ingredient for the modulation of insulinemic response, researchers investigate the impact of the supplementation of a pre-biotic compound [Jerusalem artichoke meal (JAM)] on the glycaemic and insulinemic response in healthy, non-obese warm-blooded horses.
The study included 6 adult mares fed with crushed oat grains (1 g starch/kg bwt per day) and meadow hay (2 kg/100 kg bwt per day) together with either 0.15 g fructooligosaccharides and inulin (FOS+INU)/kg bwt per day via commercial JAM or maize cob meal without grains as control (CON) in 2 × 3-week periods according to a crossover design.
According to the sample collected at the postprandial (PP) time points (-60, 0, 30, 60, 90, 120, 180, 240 and 300 min), and the plasma glucose and serum insulin levels, JAM vs. CON did not change the PP peak of glucose or insulin (glucose: 6.3 ± 0.40 vs. 7.0 ± 0.87 mmol/l.
However, following JAM feeding, glucose and insulin levels declined more rapidly until 240 min PP compared to animal fed with CON.
The finding suggested that JAM exerted a significant effect on postprandial (PP) glucose and insulin levels on and after the time points of 240 min.
Furthermore, in order to reveal more information JA insulinemic response, researchers compared the Jerusalem artichoke (Helianthus tuberosus Linne, HTL) and chungkookjang (CKJ; fermented soybeans) in energy and glucose metabolism.
The study included rats divided into partially pancreatectomized (Px) diabetic rats, and sham-operated non-diabetic control rats and all fed high-fat diets. Additionally, diabetic rats were subdivided into an untreated diabetic control group and those fed with 5% HTL, 5% CKJ or 5% HTL+5% CKJ for 8 weeks. HTL+CKJ treatment reduced visceral fat without modulating energy intake compared to diabetic control.
According to the hyperinsulinemic-euglycemic assay, rats treated HTL, HTL+CKJ showed an improvement in glucose tolerance, compared to the diabetic normal-control group.
CKJ and CKJ+HTL but not HTL, injection groups increased first and second phase insulin secretion compared to that of diabetic-control.
Moreover, the glucose infusion rates (mg/kg bw/min) and hepatic insulin sensitivity were increased and CKJ+HTL (13.5), but not HTL (9.4) or CKJ (9.5) alone, and HTL and CKJ+ HTL decreased hepatic glucose compared to diabetic control.
Dr. Yang HJ, the lead scientist wrote in the final report, "HTL and CKJ enhanced glucose tolerance in different manners, and exhibited partially additive and complementary effects by reversing insulin resistance and enhancing β-cell function in diabetic rats".
Taken altogether, artichoke used alone or combined with another herbal remedy may be considered functional food for the enhancement of insulinemic response against the onset of diabetes, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Glycaemic and insulinaemic responses of adult healthy warm-blooded mares following feeding with Jerusalem artichoke meal by Glatter M1, Bochnia M1, Goetz F1, Gottschalk J2, Koeller G3, Mielenz N4, Hillegeist D5, Greef JM5, Einspanier A2, Zeyner A. (PubMed)
(2) Jerusalem artichoke and chungkookjang additively improve insulin secretion and sensitivity in diabetic rats by Yang HJ1, Kwon DY, Kim MJ, Kang S, Kim DS, Park S. (PubMed)
(3) What causes the insulin resistance underlying obesity? by Olga T. Hardy, Michael P. Czech, and Silvia Corvera. (PMC)
Tuesday, February 4, 2020
Herbal Ashwagandha Destroys Colorectal Cancer Cells
The bowel is divided into the small bowel (or small intestine) and the large bowel (or colon and rectum).
The large intestine formed a part of the bowel in the digestive system is involved in the absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body.
Colorectal cancer is the chronic diseases associated with a malignant tumor in the colon or rectum that begins in the cell on the surface of the inner lining of the colon or rectum before proliferating into deeper tissues to form a tumor due to the alternation of cell DNA.
Most cases of colorectal cancer are diagnosed in developed countries, including the U.S. and Canada.
The disease also is relatively very common and slowly growing and progressing cancer with a tendency that is easy to predict.
According to the statistics provided by the American Cancer Society in 2019, approximately
101,420 new cases of colon cancer and 44,180 new cases of rectal cancer will be diagnosed in the US.
Furthermore, the overall, lifetime risk colorectal cancer of developing is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.
Due to the slow growth in nature, most people with colorectal cancer do not experience any symptoms until the advanced stage.
Most common symptoms of colorectal cancer at the late stage can induce symptoms of change of bowel movement, bloody stool and persistent abdominal discomforts, such as cramps, gas or pain, accompanied by the unintended weight loss, fatigue and loss of appetite,
If you experience some of the above symptoms, please contact your doctor to rule out the possibility of colorectal cancer.
At this advanced stage, colorectal cancer cells can also travel a distance away to infect other healthy tissue and organs, leading to a second metastasis.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent ingredient for the treatment of colorectal cancer, scientists investigated the effects of Withaferin A (WA), an active steroidal lactone derived from the herbal plant Withania somnifera (Ashwagandha), on reactive oxygen species (ROS) induced colorectal cancer model.
According to the tested differentiation, withaferin A showed significant activity in inducing apoptosis and cell cycle arrest in human colon cancer cells.
ROS accumulation that causes mitochondrial dysfunction associated with a cellular network of organelles involved cancer cell progression was also eradicated by the injection of withaferin A.
In other words, withaferin A-induced ROS-mediated cell cycle arrest and the expression of apoptotic proteins by promoting colorectal cancer cell death resulting in decreased mitochondrial membrane potential accompanying with mitochondrial dysfunction.
On HCT-116 and RKO cells, WA exhibited cytotoxicity in a dose-dependent manner.
Based on the findings, researchers said, " these results strongly indicated that WA directly inhibits cell growth and induces apoptosis in CRC cells through ROS-mediated mitochondrial dysfunction and c-Jun N-terminal kinases (JNKs) induced apoptosis)".
Taken altogether, Ashwagandha processed abundantly bioactive compound withaferin A may be considered a functional herb for the prevention and treatment of colorectal cancer, pending to larger sample and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Withaferin A induces apoptosis by ROS-dependent mitochondrial dysfunction in human colorectal cancer cells by Xia S1, Miao Y2, Liu S. (PubMed)
(2) Withaferin-A Inhibits Colon Cancer Cell Growth by Blocking STAT3 Transcriptional Activity by Choi BY1, Kim BW. (PubMed)
The large intestine formed a part of the bowel in the digestive system is involved in the absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body.
Colorectal cancer is the chronic diseases associated with a malignant tumor in the colon or rectum that begins in the cell on the surface of the inner lining of the colon or rectum before proliferating into deeper tissues to form a tumor due to the alternation of cell DNA.
Most cases of colorectal cancer are diagnosed in developed countries, including the U.S. and Canada.
The disease also is relatively very common and slowly growing and progressing cancer with a tendency that is easy to predict.
According to the statistics provided by the American Cancer Society in 2019, approximately
101,420 new cases of colon cancer and 44,180 new cases of rectal cancer will be diagnosed in the US.
Furthermore, the overall, lifetime risk colorectal cancer of developing is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.
Due to the slow growth in nature, most people with colorectal cancer do not experience any symptoms until the advanced stage.
Most common symptoms of colorectal cancer at the late stage can induce symptoms of change of bowel movement, bloody stool and persistent abdominal discomforts, such as cramps, gas or pain, accompanied by the unintended weight loss, fatigue and loss of appetite,
If you experience some of the above symptoms, please contact your doctor to rule out the possibility of colorectal cancer.
At this advanced stage, colorectal cancer cells can also travel a distance away to infect other healthy tissue and organs, leading to a second metastasis.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent ingredient for the treatment of colorectal cancer, scientists investigated the effects of Withaferin A (WA), an active steroidal lactone derived from the herbal plant Withania somnifera (Ashwagandha), on reactive oxygen species (ROS) induced colorectal cancer model.
According to the tested differentiation, withaferin A showed significant activity in inducing apoptosis and cell cycle arrest in human colon cancer cells.
ROS accumulation that causes mitochondrial dysfunction associated with a cellular network of organelles involved cancer cell progression was also eradicated by the injection of withaferin A.
In other words, withaferin A-induced ROS-mediated cell cycle arrest and the expression of apoptotic proteins by promoting colorectal cancer cell death resulting in decreased mitochondrial membrane potential accompanying with mitochondrial dysfunction.
On HCT-116 and RKO cells, WA exhibited cytotoxicity in a dose-dependent manner.
Based on the findings, researchers said, " these results strongly indicated that WA directly inhibits cell growth and induces apoptosis in CRC cells through ROS-mediated mitochondrial dysfunction and c-Jun N-terminal kinases (JNKs) induced apoptosis)".
Taken altogether, Ashwagandha processed abundantly bioactive compound withaferin A may be considered a functional herb for the prevention and treatment of colorectal cancer, pending to larger sample and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Withaferin A induces apoptosis by ROS-dependent mitochondrial dysfunction in human colorectal cancer cells by Xia S1, Miao Y2, Liu S. (PubMed)
(2) Withaferin-A Inhibits Colon Cancer Cell Growth by Blocking STAT3 Transcriptional Activity by Choi BY1, Kim BW. (PubMed)
Herbal Chamomile, the Best Neuro-protective Remedy
Herbal Chamomile processed a high amount of antioxidants may have a strong and profound neuroprotective effect against the onset of cognitive impairment, according to studies.
Cognitive impairment is a medical condition associated with a decline in cognitive abilities, including memory and thinking skills.
Approximately 15 to 20% of cognitive impairment is diagnosed in people age 65 or older. However, if the condition of cognitive impairment gets worse over time, it eventually leads to dementia that compromises social and/or occupational functioning.
In the early stage of cognitive impairment, patients may experience symptoms of hallucinations. delusions, personality changes, apathy, and some depression and anxiety symptoms.
If you are experiencing some of the above symptoms, please make you check with your doctors to rule out the possibility.
Although there are many factors associated with the onset of cognitive impairment, some researchers suggested that aging is the major cause of the condition in the Western world.
Therefore, finding a strategy for the delay of cognitive impairment in the elderly has become more urgent. Dr. Blanka Klimova, and colleagues in the dementia team at the University Hospital Hradec Kralove and University Hradec Kralove in the concern of the risk of cognitive impairment in aging wrote, " physical activities, such as walking and aerobic exercises, music therapy, adherence to Mediterranean diet, or solving crosswords, seem to be very promising lifestyle intervention tools"
And, "The results indicate that non-pharmacological lifestyle intervention activities should be intense and possibly done simultaneously in order to be effective in the prevention of cognitive decline. In addition, more longitudinal randomized controlled trials are needed in order to discover the most effective types and the duration of these intervention activities in the prevention of cognitive decline, typical of aging population groups"
Chamomile is also known as camomile, the common name of many species daisy-like plants in the family Asteraceae.
The herb has been used in traditional medicine as an antispasmodic and anti-inflammatory constituent and for the treatment of menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.
Scientists on finding an herbal remedy which processes neuroprotective effects examined the chamomile activity against the onset of oxidative stress which is considered a key role in the pathophysiology of many neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease.
Aluminum fluoride (AlF₄⁻)-induced oxidative stress in rats selected to the study were divided randomly into group I received normal saline; group II received AlF₄⁻ (negative control); groups III, IV, and V received 100, 200, and 300 mg/kg, orally, German chamomile methanol extract (GCME) along with AlF₄⁻; and group VI received quercetin (25 mg/kg, i.p.) + AlF₄⁻, respectively.
The experiment included a 10 days treatment with GCME before the animal induced oxidative stress by administering AlF₄⁻ through drinking water for 7 days.
Administration of GCME inhibited the levels of oxidative stress through increasing the production of antioxidant enzymes produced by the host and a decrease in lipid peroxidation (LPO).
Compared with the negative control group (P < 0.001), chamomile displayed a potent neuroprotective action against oxidative brain damage.
In rat induced oxidative stress by global cerebral ischemia/reperfusion (I/R) injury, application of methanolic extract showed dose-dependent neuroprotective activity by a significant decrease in lipid peroxidation (LPO) and increase in the superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) similar to that of the above study.
The treatment group also showed a significantly reduced vertebral infarction area in extract-treated groups, compared to the untreated group.
Dr. Chandrashekhar VM, the lead scientists, said, "The methanolic extract of Matricaria recutita L. showed potent neuroprotective activity against global cerebral ischemia/reperfusion injury-induced oxidative stress in rats".
Taken altogether, herbal chamomile which demonstrates the brain neurons' protective effect against oxidative stress in the initiation of neurodegenerative diseases, may be considered a functional remedy for the prevention and combined with primary therapy for the treatment of dementia.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Neuroprotective activity of Matricaria recutita against fluoride-induced stress in rats by Ranpariya VL1, Parmar SK, Sheth NR, Chandrashekhar VM.(PubMed)
(2) Neuroprotective activity of Matricaria recutita Linn against global model of ischemia in rats vy Chandrashekhar VM1, Ranpariya VL, Ganapaty S, Parashar A, Muchandi AA(PubMed)
(3) Cognitive decline in normal aging and its prevention: a review on non-pharmacological lifestyle strategies by Blanka Klimova,1,2 Martin Valis,2 and Kamil Kuca. (PMC)
Cognitive impairment is a medical condition associated with a decline in cognitive abilities, including memory and thinking skills.
Approximately 15 to 20% of cognitive impairment is diagnosed in people age 65 or older. However, if the condition of cognitive impairment gets worse over time, it eventually leads to dementia that compromises social and/or occupational functioning.
In the early stage of cognitive impairment, patients may experience symptoms of hallucinations. delusions, personality changes, apathy, and some depression and anxiety symptoms.
If you are experiencing some of the above symptoms, please make you check with your doctors to rule out the possibility.
Although there are many factors associated with the onset of cognitive impairment, some researchers suggested that aging is the major cause of the condition in the Western world.
Therefore, finding a strategy for the delay of cognitive impairment in the elderly has become more urgent. Dr. Blanka Klimova, and colleagues in the dementia team at the University Hospital Hradec Kralove and University Hradec Kralove in the concern of the risk of cognitive impairment in aging wrote, " physical activities, such as walking and aerobic exercises, music therapy, adherence to Mediterranean diet, or solving crosswords, seem to be very promising lifestyle intervention tools"
And, "The results indicate that non-pharmacological lifestyle intervention activities should be intense and possibly done simultaneously in order to be effective in the prevention of cognitive decline. In addition, more longitudinal randomized controlled trials are needed in order to discover the most effective types and the duration of these intervention activities in the prevention of cognitive decline, typical of aging population groups"
Chamomile is also known as camomile, the common name of many species daisy-like plants in the family Asteraceae.
The herb has been used in traditional medicine as an antispasmodic and anti-inflammatory constituent and for the treatment of menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.
Scientists on finding an herbal remedy which processes neuroprotective effects examined the chamomile activity against the onset of oxidative stress which is considered a key role in the pathophysiology of many neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease.
Aluminum fluoride (AlF₄⁻)-induced oxidative stress in rats selected to the study were divided randomly into group I received normal saline; group II received AlF₄⁻ (negative control); groups III, IV, and V received 100, 200, and 300 mg/kg, orally, German chamomile methanol extract (GCME) along with AlF₄⁻; and group VI received quercetin (25 mg/kg, i.p.) + AlF₄⁻, respectively.
The experiment included a 10 days treatment with GCME before the animal induced oxidative stress by administering AlF₄⁻ through drinking water for 7 days.
Administration of GCME inhibited the levels of oxidative stress through increasing the production of antioxidant enzymes produced by the host and a decrease in lipid peroxidation (LPO).
Compared with the negative control group (P < 0.001), chamomile displayed a potent neuroprotective action against oxidative brain damage.
In rat induced oxidative stress by global cerebral ischemia/reperfusion (I/R) injury, application of methanolic extract showed dose-dependent neuroprotective activity by a significant decrease in lipid peroxidation (LPO) and increase in the superoxide dismutase (SOD), catalase (CAT), glutathione (GSH) similar to that of the above study.
The treatment group also showed a significantly reduced vertebral infarction area in extract-treated groups, compared to the untreated group.
Dr. Chandrashekhar VM, the lead scientists, said, "The methanolic extract of Matricaria recutita L. showed potent neuroprotective activity against global cerebral ischemia/reperfusion injury-induced oxidative stress in rats".
Taken altogether, herbal chamomile which demonstrates the brain neurons' protective effect against oxidative stress in the initiation of neurodegenerative diseases, may be considered a functional remedy for the prevention and combined with primary therapy for the treatment of dementia.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Neuroprotective activity of Matricaria recutita against fluoride-induced stress in rats by Ranpariya VL1, Parmar SK, Sheth NR, Chandrashekhar VM.(PubMed)
(2) Neuroprotective activity of Matricaria recutita Linn against global model of ischemia in rats vy Chandrashekhar VM1, Ranpariya VL, Ganapaty S, Parashar A, Muchandi AA(PubMed)
(3) Cognitive decline in normal aging and its prevention: a review on non-pharmacological lifestyle strategies by Blanka Klimova,1,2 Martin Valis,2 and Kamil Kuca. (PMC)
Garlic: Whole food medicine for Reduced Risk and Treatment of Lung Cancer
Garlic (Allium sativum) is a species in the onion genus, belonging to family Amaryllidaceae, native to central Asia. It has been used popularly in traditional and Chinese medicine in treating common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotics, etc.
Lung cancer is defined as a condition of the abnormal growth of the cells in the lung's tissue. The most common form of primary lung cancers is derived from epithelial cells. In the Us, Lung cancer is the leading cause of cancer deaths, causing 158,683 people deaths, including 88,329 men and 70,354 women, according to the 2007 statistic.
A recent study suggested that garlic may be used as chemoprevention and treatment of lung cancer.
According to the study by Medical Research Center, College of Medicine allyl sulfur compounds and garlic extract found in garlic exhibited anti nonsmall cell lung cancer cell lines effects through interference on tumor cell division and tumor cell proliferation.
Benzo(a)pyrene-induced precancerous carcinogenesis in human lung cells, oil-soluble organosulfur compounds in garlic induced suppression of cell proliferation, cell cycle regulation, attenuation of ROS formation, inhibition of DNA damage, after administration.
The examination of the association between raw garlic consumption and lung cancer, a case-control study conducted between 2005 and 2007 in Taiyuan, China, showed that compared with no intake, raw garlic intake is associated with a lower risk of development of lung cancer with a dose-response pattern.
In fact, the Epidemiologic data collected by face-to-face interviews using a standard questionnaire among 1,424 lung cancer cases and 4,543 healthy controls also supported the negation of garlic intake and lung disease and suggested that garlic may potentially serve as a chemopreventive agent for lung cancer.
Dr. Yang GQ, the lead researchers at the 107th Hospital of the People's Liberation Army said, "black garlic extract (BGE) could have a significant inhibitory action on the growth of lung cancer Lewis cells. The combination of BGE and radiotherapy (by 60Co gamma) significantly induced Lewis cells' apoptosis in G2/M stage".
Whole food garlic in reduced risk and treatment of lung cancer probably is due to the effect of its' phytochemicals. Adding a portion of garlic in your diet is beneficial for increased protection against lung cancer development.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Effects of allyl sulfur compounds and garlic extract on the expression of Bcl-2, Bax, and p53 in non small cell lung cancer cell lines by Hong YS1, Ham YA, Choi JH, Kim J.(PubMed)
(2) Inhibitory effects of S-allylmercaptocysteine against benzo(a)pyrene-induced precancerous carcinogenesis in human lung cells by Wang K1, Wang Y1, Qi Q1, Zhang F1, Zhang Y2, Zhu X1, Liu G1, Luan Y1, Zhao Z3, Cai J4, Cao J4, Li S4.(PubMed)
(3) Raw Garlic Consumption and Lung Cancer in a Chinese Population by Myneni AA1, Chang SC2, Niu R3, Liu L4, Swanson MK1, Li J5, Su J5, Giovino GA6, Yu S5, Zhang ZF2, Mu L7.(PubMed)
(4) Raw garlic consumption as a protective factor for lung cancer, a population-based case-control study in a Chinese population by Jin ZY1, Wu M, Han RQ, Zhang XF, Wang XS, Liu AM, Zhou JY, Lu QY, Zhang ZF, Zhao JK.(PubMed)
(5) [Radiosensitization effect of black garlic extract on lung cancer cell line Lewis cells].[Article in Chinese] byYang GQ1, Wang D, Wang YS, Wang YY, Yang K.(PubMed)
Lung cancer is defined as a condition of the abnormal growth of the cells in the lung's tissue. The most common form of primary lung cancers is derived from epithelial cells. In the Us, Lung cancer is the leading cause of cancer deaths, causing 158,683 people deaths, including 88,329 men and 70,354 women, according to the 2007 statistic.
A recent study suggested that garlic may be used as chemoprevention and treatment of lung cancer.
According to the study by Medical Research Center, College of Medicine allyl sulfur compounds and garlic extract found in garlic exhibited anti nonsmall cell lung cancer cell lines effects through interference on tumor cell division and tumor cell proliferation.
Benzo(a)pyrene-induced precancerous carcinogenesis in human lung cells, oil-soluble organosulfur compounds in garlic induced suppression of cell proliferation, cell cycle regulation, attenuation of ROS formation, inhibition of DNA damage, after administration.
The examination of the association between raw garlic consumption and lung cancer, a case-control study conducted between 2005 and 2007 in Taiyuan, China, showed that compared with no intake, raw garlic intake is associated with a lower risk of development of lung cancer with a dose-response pattern.
In fact, the Epidemiologic data collected by face-to-face interviews using a standard questionnaire among 1,424 lung cancer cases and 4,543 healthy controls also supported the negation of garlic intake and lung disease and suggested that garlic may potentially serve as a chemopreventive agent for lung cancer.
Dr. Yang GQ, the lead researchers at the 107th Hospital of the People's Liberation Army said, "black garlic extract (BGE) could have a significant inhibitory action on the growth of lung cancer Lewis cells. The combination of BGE and radiotherapy (by 60Co gamma) significantly induced Lewis cells' apoptosis in G2/M stage".
Whole food garlic in reduced risk and treatment of lung cancer probably is due to the effect of its' phytochemicals. Adding a portion of garlic in your diet is beneficial for increased protection against lung cancer development.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Effects of allyl sulfur compounds and garlic extract on the expression of Bcl-2, Bax, and p53 in non small cell lung cancer cell lines by Hong YS1, Ham YA, Choi JH, Kim J.(PubMed)
(2) Inhibitory effects of S-allylmercaptocysteine against benzo(a)pyrene-induced precancerous carcinogenesis in human lung cells by Wang K1, Wang Y1, Qi Q1, Zhang F1, Zhang Y2, Zhu X1, Liu G1, Luan Y1, Zhao Z3, Cai J4, Cao J4, Li S4.(PubMed)
(3) Raw Garlic Consumption and Lung Cancer in a Chinese Population by Myneni AA1, Chang SC2, Niu R3, Liu L4, Swanson MK1, Li J5, Su J5, Giovino GA6, Yu S5, Zhang ZF2, Mu L7.(PubMed)
(4) Raw garlic consumption as a protective factor for lung cancer, a population-based case-control study in a Chinese population by Jin ZY1, Wu M, Han RQ, Zhang XF, Wang XS, Liu AM, Zhou JY, Lu QY, Zhang ZF, Zhao JK.(PubMed)
(5) [Radiosensitization effect of black garlic extract on lung cancer cell line Lewis cells].[Article in Chinese] byYang GQ1, Wang D, Wang YS, Wang YY, Yang K.(PubMed)
Monday, February 3, 2020
Ginger In the Prevention and Treatment of Nonalcoholic Hepatic Steatosis (Fatty Liver)
Ginger may have a profound effect in reducing the risk and treatment of hepatic steatosis, the early stage of liver disease, some scientists suggested.
Hepatic steatosis or fatty liver is a condition that caused excess fat accumulated in the liver.
At the early stage of hepatic steatosis, the patient may not experience any symptoms. However, at the condition of progress, the condition induces liver inflammation, which may progress to scarring and irreversible damage. Patients at this stage can have symptoms of abdominal swelling, enlarged blood vessels in the skin and spleen accompanied by jaundice.
The most common risk factors are the increase in age, (older than 45 years of age). overweight and obesity and ethnicity.
However, some researchers suggested the coincidence of widespread obesity and the onset of hepatic steatosis might indicate a closed correlation of the e2 conditions.
Dr. Festi D, the lead author in the finding the relation between obesity and hepatic steatosis that causes a wide spectrum of liver damage as simple steatosis may progress to advanced fibrosis and to cryptogenic cirrhosis through steatohepatitis launched an investigation to examine the risk of hepatic steatosis in obese patients.
After taking account co and confounders wrote, "Obesity is the most significant single risk factor for the development of fatty liver, both in children and in adults; obesity is also predictive of the presence of fibrosis, potentially progressing to advanced liver disease".
The risk of the fatty liver may be associated with insulin resistance in the obese patients that play a central role in the accumulation of triglycerides within the hepatocytes and in the initiation of the inflammatory cascade.
Although conventional treatment with insulin-sensitizing agents, anti-oxidants or cytoprotective drugs may be useful, however, they are no randomized clinical trials to support the efficacy.
As of today, there is no direct treatment of hepatic steatosis but relieve the symptoms.
Some researchers suggested, modifications in lifestyle (e.g. diet and exercise) to reduce obesity remain the mainstay of prevention and treatment of a disease,
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
It has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
In finding a natural whole food that may have a potent to prevent and treat nonalcoholic fatty liver, researchers at the Tajen University, Yanpu Township investigate the effects of [6]-gingerol ((S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone) in experimental models of the non-alcoholic fatty liver.
[6]-Gingerol (100 µmol/l) inhibited OA-induced triglyceride and inflammatory marker accumulation in HepG2 cells.
In the study of male golden hamsters were dosed orally with [6]-gingerol (25, 50 or 100 mg/kg/day) once daily for 8 weeks after being fed a high-fat diet (HFD) for 2 weeks, injection of [6]-Gingerol (100 mg/kg/day) alleviated liver steatosis, inflammation, and reversed plasma markers of metabolic syndrome in HFD-fed hamsters.
[6]-gingerol also attenuated the expression of inflammatory cytokine genes and nuclear transcription factor-κB (NF-κB) increased in the HFD group.
These results indicated a significant effect of [6]-Gingerol in the attenuation of the HFD-induced steatohepatitis by downregulating NF-κB-mediated inflammatory responses and reducing hepatic lipogenic gene expression.
Additionally, in the concern of widespread Nonalcoholic fatty liver disease (NAFLD) may reach epidemic proportions, Dr. Sahebkar A. launched a study to evaluate the ginger effect at the "two-stage hypothesis" proposed for the pathophysiology of NAFLD, insulin resistance, oxidative stress and pro-inflammatory cytokines among the key promoters of the disease.
Application of ginger prevent NAFLD or blunt its progression via several mechanisms, such as sensitizing insulin effects, and down-regulates pro-inflammatory cytokines.
Ginger promoted considerable antioxidant effects and antidyslipidemic properties and reduced hepatic triglyceride content which can prevent steatosis.
All these mechanisms suggested that ginger possesses interesting potentials for serving as a natural supplement for the prevention and treatment of NAFLD.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [6]-gingerol dampens hepatic steatosis and inflammation in experimental nonalcoholic steatohepatitis by Tzeng TF1, Liou SS1, Chang CJ1, Liu IM. (PubMed)
(2) Potential efficacy of ginger as a natural supplement for nonalcoholic fatty liver disease by Sahebkar A. (PubMed)
(3) Hepatic steatosis in obese patients: clinical aspects and prognostic significance by Festi D1, Colecchia A, Sacco T, Bondi M, Roda E, Marchesini G.(PubMed)
Hepatic steatosis or fatty liver is a condition that caused excess fat accumulated in the liver.
At the early stage of hepatic steatosis, the patient may not experience any symptoms. However, at the condition of progress, the condition induces liver inflammation, which may progress to scarring and irreversible damage. Patients at this stage can have symptoms of abdominal swelling, enlarged blood vessels in the skin and spleen accompanied by jaundice.
The most common risk factors are the increase in age, (older than 45 years of age). overweight and obesity and ethnicity.
However, some researchers suggested the coincidence of widespread obesity and the onset of hepatic steatosis might indicate a closed correlation of the e2 conditions.
Dr. Festi D, the lead author in the finding the relation between obesity and hepatic steatosis that causes a wide spectrum of liver damage as simple steatosis may progress to advanced fibrosis and to cryptogenic cirrhosis through steatohepatitis launched an investigation to examine the risk of hepatic steatosis in obese patients.
After taking account co and confounders wrote, "Obesity is the most significant single risk factor for the development of fatty liver, both in children and in adults; obesity is also predictive of the presence of fibrosis, potentially progressing to advanced liver disease".
The risk of the fatty liver may be associated with insulin resistance in the obese patients that play a central role in the accumulation of triglycerides within the hepatocytes and in the initiation of the inflammatory cascade.
Although conventional treatment with insulin-sensitizing agents, anti-oxidants or cytoprotective drugs may be useful, however, they are no randomized clinical trials to support the efficacy.
As of today, there is no direct treatment of hepatic steatosis but relieve the symptoms.
Some researchers suggested, modifications in lifestyle (e.g. diet and exercise) to reduce obesity remain the mainstay of prevention and treatment of a disease,
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
It has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
In finding a natural whole food that may have a potent to prevent and treat nonalcoholic fatty liver, researchers at the Tajen University, Yanpu Township investigate the effects of [6]-gingerol ((S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone) in experimental models of the non-alcoholic fatty liver.
[6]-Gingerol (100 µmol/l) inhibited OA-induced triglyceride and inflammatory marker accumulation in HepG2 cells.
In the study of male golden hamsters were dosed orally with [6]-gingerol (25, 50 or 100 mg/kg/day) once daily for 8 weeks after being fed a high-fat diet (HFD) for 2 weeks, injection of [6]-Gingerol (100 mg/kg/day) alleviated liver steatosis, inflammation, and reversed plasma markers of metabolic syndrome in HFD-fed hamsters.
[6]-gingerol also attenuated the expression of inflammatory cytokine genes and nuclear transcription factor-κB (NF-κB) increased in the HFD group.
These results indicated a significant effect of [6]-Gingerol in the attenuation of the HFD-induced steatohepatitis by downregulating NF-κB-mediated inflammatory responses and reducing hepatic lipogenic gene expression.
Additionally, in the concern of widespread Nonalcoholic fatty liver disease (NAFLD) may reach epidemic proportions, Dr. Sahebkar A. launched a study to evaluate the ginger effect at the "two-stage hypothesis" proposed for the pathophysiology of NAFLD, insulin resistance, oxidative stress and pro-inflammatory cytokines among the key promoters of the disease.
Application of ginger prevent NAFLD or blunt its progression via several mechanisms, such as sensitizing insulin effects, and down-regulates pro-inflammatory cytokines.
Ginger promoted considerable antioxidant effects and antidyslipidemic properties and reduced hepatic triglyceride content which can prevent steatosis.
All these mechanisms suggested that ginger possesses interesting potentials for serving as a natural supplement for the prevention and treatment of NAFLD.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [6]-gingerol dampens hepatic steatosis and inflammation in experimental nonalcoholic steatohepatitis by Tzeng TF1, Liou SS1, Chang CJ1, Liu IM. (PubMed)
(2) Potential efficacy of ginger as a natural supplement for nonalcoholic fatty liver disease by Sahebkar A. (PubMed)
(3) Hepatic steatosis in obese patients: clinical aspects and prognostic significance by Festi D1, Colecchia A, Sacco T, Bondi M, Roda E, Marchesini G.(PubMed)
Herbal Bilberry Reduces Risk of Macular Degeneration
Macular degeneration is a condition caused by the deterioration of the small central portion of the retina, known as the macula.
Macular degeneration happened mostly in adults over 60, is one of the major cause of vision loss.
The exact causes of macular degeneration are not identified. As of today, researchers cannot explain why some elderly are susceptible to macular degeneration while others do not.
There are 2 forms of macular degeneration
1. The dry form is caused by the presence of yellow deposits, called drusen under the retina, in the macula. However, the elderly with increased was not at a higher risk of macular degeneration.
2. The wet form is caused by the growth of abnormal blood vessels from the choroid, the vascular layer of the eye, underneath the retina.
Compared to the loss of vision of 10% of patients induced by the wet form, most patients of macular degeneration have the dry form which has been found to cause loss of some central vision.
Although aging is one the prevalent risk of the macular degeneration onset, smoking, family history, gender, ethnicity and long-term exposure to the sun and genetic preposition are also some factors may facilitate the early onset of the condition.
Some researchers suggested that macular degeneration may also be caused by an unhealthy diet.
Dr. Chung-Jung Chiu, the lead scientist in the analysis of the relationship of major American dietary patterns to age-related macular degeneration wrote, " (In the comparison of the 2 diets pattern) The Oriental pattern was characterized by higher intake of vegetables, legumes, fruit, whole grains, tomatoes, and seafood. The Western pattern was characterized by higher intake of red meat, processed meat, high-fat dairy products, French fries, refined grains, and eggs".
"For early AMD, multivariate-adjusted odds ratio (OR) from generalized estimating equation logistic analysis comparing the highest to lowest quintile of the Oriental pattern score was ORE5O=0.74 (95% confidence interval (CI): 0.59–0.91; Ptrend=0.01), and the OR comparing the highest to lowest quintile of the Western pattern score was ORE5W=1.56 (1.18–2.06; Ptrend=0.01). For advanced AMD, the ORA5O was 0.38 (0.27–0.54; Ptrend<0.0001), and the ORA5W was 3.70 (2.31–5.92; Ptrend<0.0001)".
These results strongly suggested the risk of AMD is many folds higher in people who follow the Western diet compared to those who follow the Oriental diet.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Searching the list of natural compounds for the treatment of vision decline, scientists examined anthocyanins, bioactive compounds found in bilberry are known to have antioxidant, anti-inflammatory, on macular degeneration.
Bilberry anthocyanosides (Vaccinium myrtillus L.), according to the differentiation was found to promote rhodopsin synthesis and regeneration, thus increasing the retinal sensitivity to changes in light intensity and visual acuity and dark adaptation.
The bioactive compound also was found to the promoted blood supply of the retina in the prevention of macular degeneration due to aging-induced death of macula cells.
Where rhodopsin is the pigment-containing sensory protein that converts light into an electrical signal for vision in dim light
The improvement of the visual function by bilberry may have a strong effect against age-related macular degeneration, Dr. Vorob'eva IV, the lead scientists suggested.
Additionally, with an aim to reveal more information of bilberry anti gradual loss of vision, researchers investigated the changes in clinical, functional, and morphological parameters of the retina in type 2 diabetes patients with diabetic retinopathy (DR) and those with combined fundus pathology (DR plus age-related macular degeneration).
The study included 180 patients (180 eyes) with type 2 diabetes divided into 6 groups of 30 each randomly assigned into group 1 consisted of patients with DRO,; group 2--DR1 without DM, group 3--DR1 with DM, group 4--DRO and "dry" AMD (AREDS 1-3), group 5--DR1 with no DM but with AMD (AREDS 1-3), and group 6--DR1 with DM and AMD (AREDS 1-3).
A drug-containing lutein 6 mg, zeaxanthin 0.5 mg, vitamin C 60 mg, vitamin E 7 mg, vitamin A 1.5 mg, vitamin B2 1.2 mg, rutin 25 mg, zinc 5 mg, Selenium 25 mcg, and bilberry extract 60 mg was used for antioxidative therapy. Ginkgo biloba leaf extracts 60 mg was chosen as the radioprotector.
At the end of the experiment, researchers found that
* Macular thickness was statistically significant only in 3 and 6 (p<0.05)compared to only slight changes on other groups and light sensitivity of the macula showed a reduction, which was statistically significant in groups 4-6 before treatment.
* Injection of the supplements antioxidant and angio-protective activities displayed a strong improvement of all parameters related to visual decline, including increased visual acuity.
Dr. the lead scientist wrote in the final report, "a combined antioxidant and double-dose angio-protective (240 mg) therapy appeared to be the most effective and can be considered not only a preventive but also a therapeutic measure in type 2 diabetes patients with initial stages of DR (DRO, DR1) or those with DR and DM or combined DR and AMD (AREDS 1-3)".
Taken altogether, bilberry may be considered a herbal remedy for the improvement of visual decline, particularly, in patients with macular degeneration, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(2) [Current data on the role of anthocyanosides and flavonoids in the treatment of eye diseases].[Article in Russian; Abstract available in Russian from the publisher] by Vorob'eva IV1, Vorob'eva IV. (PubMed)
(1) [Results of the use of antioxidant and angioprotective agents in type 2 diabetes patients with diabetic retinopathy and age-related macular degeneration].[Article in Russian; Abstract available in Russian from the publisher] by Moshetova LK1, Vorob'eva IV1, Alekseev IB1, Mikhaleva LG. (PubMed)
(3) The Relationship of Major American Dietary Patterns to Age-related Macular Degeneration by Chung-Jung Chiu, DDS, PhD, Min-Lee Chang, MS, Fang Fang Zhang, PhD, Tricia Li, MS, Gary Gensler, MS, Molly Schleicher, BS, and Allen Taylor, PhD. (PMC)
Macular degeneration happened mostly in adults over 60, is one of the major cause of vision loss.
The exact causes of macular degeneration are not identified. As of today, researchers cannot explain why some elderly are susceptible to macular degeneration while others do not.
There are 2 forms of macular degeneration
1. The dry form is caused by the presence of yellow deposits, called drusen under the retina, in the macula. However, the elderly with increased was not at a higher risk of macular degeneration.
2. The wet form is caused by the growth of abnormal blood vessels from the choroid, the vascular layer of the eye, underneath the retina.
Compared to the loss of vision of 10% of patients induced by the wet form, most patients of macular degeneration have the dry form which has been found to cause loss of some central vision.
Although aging is one the prevalent risk of the macular degeneration onset, smoking, family history, gender, ethnicity and long-term exposure to the sun and genetic preposition are also some factors may facilitate the early onset of the condition.
Some researchers suggested that macular degeneration may also be caused by an unhealthy diet.
Dr. Chung-Jung Chiu, the lead scientist in the analysis of the relationship of major American dietary patterns to age-related macular degeneration wrote, " (In the comparison of the 2 diets pattern) The Oriental pattern was characterized by higher intake of vegetables, legumes, fruit, whole grains, tomatoes, and seafood. The Western pattern was characterized by higher intake of red meat, processed meat, high-fat dairy products, French fries, refined grains, and eggs".
"For early AMD, multivariate-adjusted odds ratio (OR) from generalized estimating equation logistic analysis comparing the highest to lowest quintile of the Oriental pattern score was ORE5O=0.74 (95% confidence interval (CI): 0.59–0.91; Ptrend=0.01), and the OR comparing the highest to lowest quintile of the Western pattern score was ORE5W=1.56 (1.18–2.06; Ptrend=0.01). For advanced AMD, the ORA5O was 0.38 (0.27–0.54; Ptrend<0.0001), and the ORA5W was 3.70 (2.31–5.92; Ptrend<0.0001)".
These results strongly suggested the risk of AMD is many folds higher in people who follow the Western diet compared to those who follow the Oriental diet.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
Searching the list of natural compounds for the treatment of vision decline, scientists examined anthocyanins, bioactive compounds found in bilberry are known to have antioxidant, anti-inflammatory, on macular degeneration.
Bilberry anthocyanosides (Vaccinium myrtillus L.), according to the differentiation was found to promote rhodopsin synthesis and regeneration, thus increasing the retinal sensitivity to changes in light intensity and visual acuity and dark adaptation.
The bioactive compound also was found to the promoted blood supply of the retina in the prevention of macular degeneration due to aging-induced death of macula cells.
Where rhodopsin is the pigment-containing sensory protein that converts light into an electrical signal for vision in dim light
The improvement of the visual function by bilberry may have a strong effect against age-related macular degeneration, Dr. Vorob'eva IV, the lead scientists suggested.
Additionally, with an aim to reveal more information of bilberry anti gradual loss of vision, researchers investigated the changes in clinical, functional, and morphological parameters of the retina in type 2 diabetes patients with diabetic retinopathy (DR) and those with combined fundus pathology (DR plus age-related macular degeneration).
The study included 180 patients (180 eyes) with type 2 diabetes divided into 6 groups of 30 each randomly assigned into group 1 consisted of patients with DRO,; group 2--DR1 without DM, group 3--DR1 with DM, group 4--DRO and "dry" AMD (AREDS 1-3), group 5--DR1 with no DM but with AMD (AREDS 1-3), and group 6--DR1 with DM and AMD (AREDS 1-3).
A drug-containing lutein 6 mg, zeaxanthin 0.5 mg, vitamin C 60 mg, vitamin E 7 mg, vitamin A 1.5 mg, vitamin B2 1.2 mg, rutin 25 mg, zinc 5 mg, Selenium 25 mcg, and bilberry extract 60 mg was used for antioxidative therapy. Ginkgo biloba leaf extracts 60 mg was chosen as the radioprotector.
At the end of the experiment, researchers found that
* Macular thickness was statistically significant only in 3 and 6 (p<0.05)compared to only slight changes on other groups and light sensitivity of the macula showed a reduction, which was statistically significant in groups 4-6 before treatment.
* Injection of the supplements antioxidant and angio-protective activities displayed a strong improvement of all parameters related to visual decline, including increased visual acuity.
Dr. the lead scientist wrote in the final report, "a combined antioxidant and double-dose angio-protective (240 mg) therapy appeared to be the most effective and can be considered not only a preventive but also a therapeutic measure in type 2 diabetes patients with initial stages of DR (DRO, DR1) or those with DR and DM or combined DR and AMD (AREDS 1-3)".
Taken altogether, bilberry may be considered a herbal remedy for the improvement of visual decline, particularly, in patients with macular degeneration, pending to the validation of larger sample size and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(2) [Current data on the role of anthocyanosides and flavonoids in the treatment of eye diseases].[Article in Russian; Abstract available in Russian from the publisher] by Vorob'eva IV1, Vorob'eva IV. (PubMed)
(1) [Results of the use of antioxidant and angioprotective agents in type 2 diabetes patients with diabetic retinopathy and age-related macular degeneration].[Article in Russian; Abstract available in Russian from the publisher] by Moshetova LK1, Vorob'eva IV1, Alekseev IB1, Mikhaleva LG. (PubMed)
(3) The Relationship of Major American Dietary Patterns to Age-related Macular Degeneration by Chung-Jung Chiu, DDS, PhD, Min-Lee Chang, MS, Fang Fang Zhang, PhD, Tricia Li, MS, Gary Gensler, MS, Molly Schleicher, BS, and Allen Taylor, PhD. (PMC)
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