Garlic: Whole food medicine for Reduced Risk and Treatment of Lung Cancer

Garlic (Allium sativum) is a species in the onion genus, belonging to family Amaryllidaceae, native to central Asia. It has been used popularly in traditional and Chinese medicine in treating common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotics, etc.

Lung cancer is defined as a condition of the abnormal growth of the cells in the lung's tissue. The most common form of primary lung cancers is derived from epithelial cells. In the Us, Lung cancer is the leading cause of cancer deaths, causing 158,683 people deaths, including 88,329 men and 70,354 women, according to the 2007 statistic.

A recent study suggested that garlic may be used as chemoprevention and treatment of lung cancer.

According to the study by Medical Research Center, College of Medicine allyl sulfur compounds and garlic extract found in garlic exhibited anti nonsmall cell lung cancer cell lines effects through interference on tumor cell division and tumor cell proliferation.

Benzo(a)pyrene-induced precancerous carcinogenesis in human lung cells, oil-soluble organosulfur compounds in garlic induced suppression of cell proliferation, cell cycle regulation, attenuation of ROS formation, inhibition of DNA damage, after administration.


The examination of the association between raw garlic consumption and lung cancer, a case-control study conducted between 2005 and 2007 in Taiyuan, China, showed that compared with no intake, raw garlic intake is associated with a lower risk of development of lung cancer with a dose-response pattern.

In fact, the Epidemiologic data collected by face-to-face interviews using a standard questionnaire among 1,424 lung cancer cases and 4,543 healthy controls also supported the negation of garlic intake and lung disease and suggested that garlic may potentially serve as a chemopreventive agent for lung cancer.


Dr. Yang GQ, the lead researchers at the 107th Hospital of the People's Liberation Army said, "black garlic extract (BGE) could have a significant inhibitory action on the growth of lung cancer Lewis cells. The combination of BGE and radiotherapy (by 60Co gamma) significantly induced Lewis cells' apoptosis in G2/M stage".

Whole food garlic in reduced risk and treatment of lung cancer probably is due to the effect of its' phytochemicals. Adding a portion of garlic in your diet is beneficial for increased protection against lung cancer development.


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Sources
(1) Effects of allyl sulfur compounds and garlic extract on the expression of Bcl-2, Bax, and p53 in non small cell lung cancer cell lines by Hong YS1, Ham YA, Choi JH, Kim J.(PubMed)
(2) Inhibitory effects of S-allylmercaptocysteine against benzo(a)pyrene-induced precancerous carcinogenesis in human lung cells by Wang K1, Wang Y1, Qi Q1, Zhang F1, Zhang Y2, Zhu X1, Liu G1, Luan Y1, Zhao Z3, Cai J4, Cao J4, Li S4.(PubMed)
(3) Raw Garlic Consumption and Lung Cancer in a Chinese Population by Myneni AA1, Chang SC2, Niu R3, Liu L4, Swanson MK1, Li J5, Su J5, Giovino GA6, Yu S5, Zhang ZF2, Mu L7.(PubMed)
(4) Raw garlic consumption as a protective factor for lung cancer, a population-based case-control study in a Chinese population by Jin ZY1, Wu M, Han RQ, Zhang XF, Wang XS, Liu AM, Zhou JY, Lu QY, Zhang ZF, Zhao JK.(PubMed)
(5) [Radiosensitization effect of black garlic extract on lung cancer cell line Lewis cells].[Article in Chinese] byYang GQ1, Wang D, Wang YS, Wang YY, Yang K.(PubMed)