The bowel is divided into the small bowel (or small intestine) and the large bowel (or colon and rectum).
The large intestine formed a part of the bowel in the digestive system is involved in the absorption of water from the small bowel contents and broken down of certain materials in the feces into substances of which some of them to be reabsorbed and reused by the body.
Colorectal cancer is the chronic diseases associated with a malignant tumor in the colon or rectum that begins in the cell on the surface of the inner lining of the colon or rectum before proliferating into deeper tissues to form a tumor due to the alternation of cell DNA.
Most cases of colorectal cancer are diagnosed in developed countries, including the U.S. and Canada.
The disease also is relatively very common and slowly growing and progressing cancer with a tendency that is easy to predict.
According to the statistics provided by the American Cancer Society in 2019, approximately
101,420 new cases of colon cancer and 44,180 new cases of rectal cancer will be diagnosed in the US.
Furthermore, the overall, lifetime risk colorectal cancer of developing is 1 in 22 (4.49%) for men and 1 in 24 (4.15%) for women.
Due to the slow growth in nature, most people with colorectal cancer do not experience any symptoms until the advanced stage.
Most common symptoms of colorectal cancer at the late stage can induce symptoms of change of bowel movement, bloody stool and persistent abdominal discomforts, such as cramps, gas or pain, accompanied by the unintended weight loss, fatigue and loss of appetite,
If you experience some of the above symptoms, please contact your doctor to rule out the possibility of colorectal cancer.
At this advanced stage, colorectal cancer cells can also travel a distance away to infect other healthy tissue and organs, leading to a second metastasis.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent ingredient for the treatment of colorectal cancer, scientists investigated the effects of Withaferin A (WA), an active steroidal lactone derived from the herbal plant Withania somnifera (Ashwagandha), on reactive oxygen species (ROS) induced colorectal cancer model.
According to the tested differentiation, withaferin A showed significant activity in inducing apoptosis and cell cycle arrest in human colon cancer cells.
ROS accumulation that causes mitochondrial dysfunction associated with a cellular network of organelles involved cancer cell progression was also eradicated by the injection of withaferin A.
In other words, withaferin A-induced ROS-mediated cell cycle arrest and the expression of apoptotic proteins by promoting colorectal cancer cell death resulting in decreased mitochondrial membrane potential accompanying with mitochondrial dysfunction.
On HCT-116 and RKO cells, WA exhibited cytotoxicity in a dose-dependent manner.
Based on the findings, researchers said, " these results strongly indicated that WA directly inhibits cell growth and induces apoptosis in CRC cells through ROS-mediated mitochondrial dysfunction and c-Jun N-terminal kinases (JNKs) induced apoptosis)".
Taken altogether, Ashwagandha processed abundantly bioactive compound withaferin A may be considered a functional herb for the prevention and treatment of colorectal cancer, pending to larger sample and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Withaferin A induces apoptosis by ROS-dependent mitochondrial dysfunction in human colorectal cancer cells by Xia S1, Miao Y2, Liu S. (PubMed)
(2) Withaferin-A Inhibits Colon Cancer Cell Growth by Blocking STAT3 Transcriptional Activity by Choi BY1, Kim BW. (PubMed)
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