Substances such as radionuclides, or radiation which can cause the onset of cancer with or without changing the cell DNA are considered carcinogens.
In contrast to general belief, unhealthy lifestyle, long term exposure to the sunlight, certain medical treatment such as radiation, and medications such as immune-suppressive drugs, chemical exposure may also be considered carcinogens.
However, most people exposed to the substances have never developed cancer.
According to the World Health Organization (WHO), substances that cause cancer in humans can be classified into 5 categories.
Group 1: Carcinogenic to humans
Group 2A: Probably carcinogenic to humans
Group 2B: Possibly carcinogenic to humans
Group 3: Unclassifiable as to carcinogenicity in humans
Group 4: Probably not carcinogenic to humans
The most dangerous carcinogens are placed in group 1. Therefore, if you are handling any of the substances in the group 1 (the list can be found here), please make sure you protect yourself according to the standard guidelines.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine for as liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on the finding natural therapeutics which block carcinogen in the induction of cancer investigated the antigenotoxic and antioxidant effects of the extract of artichoke Cynara cardunculus L. (CCE).
In the Saccharomyces cerevisiae mutagenicity/antimutagenicity assay, CCE significantly reduced the frequency of 4-nitroquinoline-N-oxide-induced genetics alternation in the diploid Saccharomyces cerevisiae tester strain D7.
In the simultaneous toxicity and clastogenicity/anticlastogenic assay, CCE exerted an anticlastogenic effect against N-nitroso-N'-methyl urea-induced clastogenicity in the plant species.
According to the free radical scavenging assay, CCE also exhibited considerable antioxidant activity against carcinogens.
In order to reveal more information of artichoke, anticarcinogenic activity researchers examined the genotoxicity of C. scolymus L. leaf extract (LE) and the ability to modulate the genetic toxicity of the alkylating agent ethyl methanesulfonate (EMS), using the comet assay on Chinese hamster ovary cells.
LE demonstrated strong anti genotoxicity after 1- and 24-h treatments by 4 different doses: 0.62, 1.25, 2.5, and 5.0 mg/mL, according to the results from pretreatment, simultaneous treatment, and post-treatment.
All doses also protect the cell against DNA damage induced by the alkylating agent ethyl methanesulfonate (EMS), after exposure for 1 and 24 h.
Interestingly, the lowest dose of LE was more protective than higher concentrations.
The genotoxic and antigenotoxic effects were attributed to the bioactive flavonoids and phenolic compounds found abundantly in artichoke.
Taken altogether, artichoke processed bioactive compound flavonoids and phenolic may be considered a functional remedy for the prevention and treatment of carcinogenic toxicity, with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Antigenotoxic effect of extract from Cynara cardunculus L. by Miadokova E1, Nadova S, Vlckova V, Duhova V, Kopaskova M, Cipak L, Rauko P, Mucaji P, Grancai D. (PubMed)
(2) Artichoke induces genetic toxicity and decreases ethyl methanesulfonate-related DNA damage in Chinese hamster ovary cells by Jacociunas LV1, de Andrade HH, Lehmann M, de Abreu BR, Ferraz Ade B, da Silva J, Dihl RR. (PubMed)
(3) Known and Probable Human Carcinogens by the American Cancer Society
Wednesday, February 12, 2020
Herbal Cayenne Processes Both Hypo and Hyper Tension Function In Dose Dependent- Manner
Herbal cayenne processed a significant amount of bioactive compound Capsicum may have a positive and profound effect on normalizing the levels of blood pressure, according to studies.
Hypertension is a medical condition of abnormally high blood pressure, one of the members of the cluster of conditions associated with heart disease and stroke.
Depending on the reading, some researchers suggested if you are in stage one of high blood pressure, your risk of cardiovascular disease is increased by 10% over the next 10 years.
According to the statistics, in the US, approximately 75 million people or 1 of 3 U.S. adults have high blood pressure. High blood pressure can be modified by change of lifestyle.
The most common risk factors of high blood pressure are a poor diet with high in salt and potassium and low vitamin D, physically inactive, excessive alcohol drinking, use of Non-steroidal Anti-inflammatory Drugs (NSAIDs), and aging.
However, not all people with some of the above conditions will develop high blood pressure.
Treatment of stage 1 and 2 hypertension include daily intake of diuretics which lower high blood pressure by reducing sodium and fluid through increased urinary secretion and Bumetanide (Bumex) Chlorthalidone (Hygroton) or Chlorothiazide (Diuril).
Some patients may experience side effects such as a cough, diarrhea or constipation, dizziness or nervousness, tired, weak, and nausea or vomiting.
In a serious case, high blood pressure medication may induce erectile dysfunction. If you are taking high blood pressure medications, please make sure you have discussed the side effects with your doctor.
Some researchers in the concern of the widespread of hypertension in the Western world suggested that the condition may correlate to the promotion of the Western diet over the past few decades.
Dr. Adriana Monge and colleagues examined the Western and Modern Mexican diet pattern and risk of high blood pressure, wrote, "The multivariable-adjusted odds of hypertension in the highest quartile of the Western (W) pattern were 24% higher than the odds for individuals in the lowest quartile"
And, "women in the highest quartile of the MM pattern had 15% higher odds than women in the lowest quartile. The Fruits & Vegetables (FV) pattern was not significantly associated with hypertension".
These results clearly indicated a strong connection of the Western diet pattern in the increased risk of hypertension compared to the lower risk of fruits and vegetable groups.
Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belonging to Capsicum annuum, the family Solanaceae, native to subtropical and tropical regions.
The pepper has been used in traditional medicine to increases metabolism, enhance the circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises, and neuralgia, etc.
The chemical constituents of Cayenne include capsaicin, capsacutin oil, solaine, xanthenes, oleic acid, palmitic acid, etc.
Epidemiological studies linking cayenne in reducing hypertension have not been conclusive, the mechanism of this effect is still a mystery.
Researchers on finding herbal medicine for the treatment of hypertension with no side effects examined the traditionally used medicinal plants against key enzymes relevant for hyperglycemia and hypertension.
Compared to other herbal plants, pepper (Capsicum) inhibited significantly the hypertension relevant angiotensin I-converting enzyme (ACE).
All evaluated pepper (Capsicum) genus exhibited both anti-hyperglycemia and anti-hypertension potential.
The anti-high blood pressure of cayenne probably is associated with the major compound capsaicin, chlorogenic acid, and hydroxycinnamic acid derivatives.
However, in pig study, application capsaicin isolated from the cayenne showed a significantly increased mean arterial blood pressure compared with controls, and a decrease in CGRP synthesis and release contributes to the elevated blood pressure.
Also, there are 2 cases reported of an arterial hypertensive crisis in a patient with large ingestion of peppers and chili peppers the day before and a 19-year-old Italian man with abundant ingestion of peppers and of chili peppers the preceding day.
Additionally, overdoses of cayenne not only induced arterial hypertensive crisis but also acute myocardial infarction with high levels of thyroid-stimulating hormone.
The findings strongly suggested cayenne processed an antihypertensive and hypertensive effect in a dose-dependent manner.
This dual mechanisms presented in cayenne may not be explained by conventional medicine. However, traditional Chinese medicine stated cayenne, yang in nature, promotes Qi movement of blood. In a healthy individual, the smooth movement of qi reduces the unnecessary blood pressure in blood transportation. On the other hand, if the movement of qi is blocked due to the presence of a high amount of cholesterol that narrows the blood vessel, in inducing higher blood pressure.
The traditional Chinese medicine continued, injection of a high amount of cayenne pepper can cause constriction of blood vessels, leading to narrowing blood flow and risk of hypertension
Taken all together, there is no doubt that cayenne may be considered a functional remedy for the prevention and treatment of hypertension, but the amount of intake should only be prescribed by related field specialists.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Phenolic compounds, antioxidant activity and in vitro inhibitory potential against key enzymes relevant for hyperglycemia and hypertension of commonly used medicinal plants, herbs and spices in Latin America by Ranilla LG1, Kwon YI, Apostolidis E, Shetty K.(PubMed)
(2) Capsaicin and arterial hypertensive crisis by Patanè S, Marte F, La Rosa FC, La Rocca R.(PubMed)
(3) Capsaicin, arterial hypertensive crisis and acute myocardial infarction associated with high levels of thyroid stimulating hormone by Patanè S, Marte F, Di Bella G, Cerrito M, Coglitore S.(PubMed)
(4) Western and Modern Mexican dietary patterns are directly associated with incident hypertension in Mexican women: a prospective follow-up study by Adriana Monge,1,2 Martín Lajous,1,4 Eduardo Ortiz-Panozo,1 Beatriz L. Rodríguez,2,3José Juan Góngora,2 and Ruy López-Ridaura. (PMC)
Hypertension is a medical condition of abnormally high blood pressure, one of the members of the cluster of conditions associated with heart disease and stroke.
Depending on the reading, some researchers suggested if you are in stage one of high blood pressure, your risk of cardiovascular disease is increased by 10% over the next 10 years.
According to the statistics, in the US, approximately 75 million people or 1 of 3 U.S. adults have high blood pressure. High blood pressure can be modified by change of lifestyle.
The most common risk factors of high blood pressure are a poor diet with high in salt and potassium and low vitamin D, physically inactive, excessive alcohol drinking, use of Non-steroidal Anti-inflammatory Drugs (NSAIDs), and aging.
However, not all people with some of the above conditions will develop high blood pressure.
Treatment of stage 1 and 2 hypertension include daily intake of diuretics which lower high blood pressure by reducing sodium and fluid through increased urinary secretion and Bumetanide (Bumex) Chlorthalidone (Hygroton) or Chlorothiazide (Diuril).
Some patients may experience side effects such as a cough, diarrhea or constipation, dizziness or nervousness, tired, weak, and nausea or vomiting.
In a serious case, high blood pressure medication may induce erectile dysfunction. If you are taking high blood pressure medications, please make sure you have discussed the side effects with your doctor.
Some researchers in the concern of the widespread of hypertension in the Western world suggested that the condition may correlate to the promotion of the Western diet over the past few decades.
Dr. Adriana Monge and colleagues examined the Western and Modern Mexican diet pattern and risk of high blood pressure, wrote, "The multivariable-adjusted odds of hypertension in the highest quartile of the Western (W) pattern were 24% higher than the odds for individuals in the lowest quartile"
And, "women in the highest quartile of the MM pattern had 15% higher odds than women in the lowest quartile. The Fruits & Vegetables (FV) pattern was not significantly associated with hypertension".
These results clearly indicated a strong connection of the Western diet pattern in the increased risk of hypertension compared to the lower risk of fruits and vegetable groups.
Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belonging to Capsicum annuum, the family Solanaceae, native to subtropical and tropical regions.
The pepper has been used in traditional medicine to increases metabolism, enhance the circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises, and neuralgia, etc.
The chemical constituents of Cayenne include capsaicin, capsacutin oil, solaine, xanthenes, oleic acid, palmitic acid, etc.
Epidemiological studies linking cayenne in reducing hypertension have not been conclusive, the mechanism of this effect is still a mystery.
Researchers on finding herbal medicine for the treatment of hypertension with no side effects examined the traditionally used medicinal plants against key enzymes relevant for hyperglycemia and hypertension.
Compared to other herbal plants, pepper (Capsicum) inhibited significantly the hypertension relevant angiotensin I-converting enzyme (ACE).
All evaluated pepper (Capsicum) genus exhibited both anti-hyperglycemia and anti-hypertension potential.
The anti-high blood pressure of cayenne probably is associated with the major compound capsaicin, chlorogenic acid, and hydroxycinnamic acid derivatives.
However, in pig study, application capsaicin isolated from the cayenne showed a significantly increased mean arterial blood pressure compared with controls, and a decrease in CGRP synthesis and release contributes to the elevated blood pressure.
Also, there are 2 cases reported of an arterial hypertensive crisis in a patient with large ingestion of peppers and chili peppers the day before and a 19-year-old Italian man with abundant ingestion of peppers and of chili peppers the preceding day.
Additionally, overdoses of cayenne not only induced arterial hypertensive crisis but also acute myocardial infarction with high levels of thyroid-stimulating hormone.
The findings strongly suggested cayenne processed an antihypertensive and hypertensive effect in a dose-dependent manner.
This dual mechanisms presented in cayenne may not be explained by conventional medicine. However, traditional Chinese medicine stated cayenne, yang in nature, promotes Qi movement of blood. In a healthy individual, the smooth movement of qi reduces the unnecessary blood pressure in blood transportation. On the other hand, if the movement of qi is blocked due to the presence of a high amount of cholesterol that narrows the blood vessel, in inducing higher blood pressure.
The traditional Chinese medicine continued, injection of a high amount of cayenne pepper can cause constriction of blood vessels, leading to narrowing blood flow and risk of hypertension
Taken all together, there is no doubt that cayenne may be considered a functional remedy for the prevention and treatment of hypertension, but the amount of intake should only be prescribed by related field specialists.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Phenolic compounds, antioxidant activity and in vitro inhibitory potential against key enzymes relevant for hyperglycemia and hypertension of commonly used medicinal plants, herbs and spices in Latin America by Ranilla LG1, Kwon YI, Apostolidis E, Shetty K.(PubMed)
(2) Capsaicin and arterial hypertensive crisis by Patanè S, Marte F, La Rosa FC, La Rocca R.(PubMed)
(3) Capsaicin, arterial hypertensive crisis and acute myocardial infarction associated with high levels of thyroid stimulating hormone by Patanè S, Marte F, Di Bella G, Cerrito M, Coglitore S.(PubMed)
(4) Western and Modern Mexican dietary patterns are directly associated with incident hypertension in Mexican women: a prospective follow-up study by Adriana Monge,1,2 Martín Lajous,1,4 Eduardo Ortiz-Panozo,1 Beatriz L. Rodríguez,2,3José Juan Góngora,2 and Ruy López-Ridaura. (PMC)
Tuesday, February 11, 2020
Herbal Ashwagandha Exerts Cytostatic Effect Against Multiple Myeloma In Vitro
Multiple myelomas (Myeloma) is a type of cancer originated from plasma cells in the bone marrow.
The disease is a condition of DNA alternation of white blood cell normally responsible for the production of antibodies to protect our body against infection with some characteristics.
According to the statistics provided by the American Cancer Society, multiple myeloma is a relatively uncommon cancer. In the United States, the lifetime risk of getting multiple myeloma is 1 in 132 (0.76%).
Every year, approximately, 32,110 new cases are diagnosed, including 18,130 in men and 13,980 in women. The disease also causes the death of 12,960 Americans including 6,990 in men and 5,970 in women.
The Grades of multiple myeloma are depending on the tendency of spreading. Low-grade cancers usually grow more slowly and are less likely to spread while high-grade cancer indicates otherwise.
The exact causes of MS are unknown. Epidemiologically, the increase of age (If you are between 50 and 70 years old you are at higher risk to develop Multiple Myeloma), gender (men are more likely to develop multiple myeloma than women), race (Cancer tends to affects blacks more often than whites), previous multiple myeloma, exposed to certain chemicals, family history, and radiation
Most common symptoms of MS are* Bone pain
Abnormal growth of plasma cells can cause a collapse of the bone.
* Infection
Overcrowding of abnormal plasma cells reduces the functions of white blood cells produced by the bone marrow, leading to a weakened immune system. The most common infections found to be pneumonia and pyelonephritis.
* Anemia
As a result of malignant plasma cells has to interfere with the normal production of red blood cells.
* Bleeding
Due to the lower production of the platelet.
* Renal failure
Abnormal plasma cells can also affect the function of the kidney in getting rid of waste, causing urea and creatinine accumulated in the bloodstream.
* Neurological symptoms
Due to hypercalcemia, as a result of the breakdown of the bone cause of the release of calcium into the bloodstream.
However, most people with some of the above symptoms never developed MS.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the treatment of tumor of the bone marrow, researchers examined the growth inhibitory effects of withanolide D (WND), a steroidal lactone isolated from Withania somnifera on drug-resistant subpopulation known as cancer stem cells (CSCs).
According to tested assays, WND exhibited similar cytostatic effects by inhibiting cancer cell growth and division. on drug-resistant and drug-sensitive cell lines in the nM range.
In cancer cell lines MM-CSCs and RPMI 8226, the administration of WND also induced cancer cell death and apoptosis.
However, WND did not increase the accumulation of the fluorescent P-gp substrate rhodamine 123 in MM-CSCs associated with cancer cells drug resistance. More precisely, the result suggested that WND at the tested doses may not inhibit P-gp accumulation involving in the development of resistance of cancer cells to chemotherapeutic drugs.
Based on the findings, researchers said, " the WND-induced cytostatic effect may be independent of P-gp efflux".
Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of myeloma, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Withanolide D Exhibits Similar Cytostatic Effect in Drug-Resistant and Drug-Sensitive Multiple Myeloma Cells by Issa ME1, Wijeratne EMK2, Gunatilaka AAL2, Cuendet M. (PubMed)
The disease is a condition of DNA alternation of white blood cell normally responsible for the production of antibodies to protect our body against infection with some characteristics.
According to the statistics provided by the American Cancer Society, multiple myeloma is a relatively uncommon cancer. In the United States, the lifetime risk of getting multiple myeloma is 1 in 132 (0.76%).
Every year, approximately, 32,110 new cases are diagnosed, including 18,130 in men and 13,980 in women. The disease also causes the death of 12,960 Americans including 6,990 in men and 5,970 in women.
The Grades of multiple myeloma are depending on the tendency of spreading. Low-grade cancers usually grow more slowly and are less likely to spread while high-grade cancer indicates otherwise.
The exact causes of MS are unknown. Epidemiologically, the increase of age (If you are between 50 and 70 years old you are at higher risk to develop Multiple Myeloma), gender (men are more likely to develop multiple myeloma than women), race (Cancer tends to affects blacks more often than whites), previous multiple myeloma, exposed to certain chemicals, family history, and radiation
Most common symptoms of MS are* Bone pain
Abnormal growth of plasma cells can cause a collapse of the bone.
* Infection
Overcrowding of abnormal plasma cells reduces the functions of white blood cells produced by the bone marrow, leading to a weakened immune system. The most common infections found to be pneumonia and pyelonephritis.
* Anemia
As a result of malignant plasma cells has to interfere with the normal production of red blood cells.
* Bleeding
Due to the lower production of the platelet.
* Renal failure
Abnormal plasma cells can also affect the function of the kidney in getting rid of waste, causing urea and creatinine accumulated in the bloodstream.
* Neurological symptoms
Due to hypercalcemia, as a result of the breakdown of the bone cause of the release of calcium into the bloodstream.
However, most people with some of the above symptoms never developed MS.
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound for the treatment of tumor of the bone marrow, researchers examined the growth inhibitory effects of withanolide D (WND), a steroidal lactone isolated from Withania somnifera on drug-resistant subpopulation known as cancer stem cells (CSCs).
According to tested assays, WND exhibited similar cytostatic effects by inhibiting cancer cell growth and division. on drug-resistant and drug-sensitive cell lines in the nM range.
In cancer cell lines MM-CSCs and RPMI 8226, the administration of WND also induced cancer cell death and apoptosis.
However, WND did not increase the accumulation of the fluorescent P-gp substrate rhodamine 123 in MM-CSCs associated with cancer cells drug resistance. More precisely, the result suggested that WND at the tested doses may not inhibit P-gp accumulation involving in the development of resistance of cancer cells to chemotherapeutic drugs.
Based on the findings, researchers said, " the WND-induced cytostatic effect may be independent of P-gp efflux".
Taken altogether, Ashwagandha may be considered a functional herb for the prevention and an adjunct therapy combined with the primary medicine for the treatment of myeloma, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Withanolide D Exhibits Similar Cytostatic Effect in Drug-Resistant and Drug-Sensitive Multiple Myeloma Cells by Issa ME1, Wijeratne EMK2, Gunatilaka AAL2, Cuendet M. (PubMed)
Herbal Artichoke, the Anti Diabetes Functional Herbal Remedy in Vivo
Diabetes is a medical condition caused by not enough insulin entering the bloodstream as a result of the loss of beta cells in the pancreas or insulin receptor sites clogged by plaques that are responsible for the production of insulin.
The insulin receptor sites processed a function that binds the insulin and passes the message into the cell, leading to the transformation of glucose from the blood to energy.
The hallmark of diabetes is insulin resistance. The condition has been found to increase the risk of cardiovascular disease even without the presence of diabetes.
The exact causes of insulin resistance are unknown. However, some researchers suggested that genetic preposition and lifestyle are major risk factors that cause the onset of the syndrome.
According to the statistics, in the US, between 60 to 70 million individuals are affected by insulin resistance. More than 40% of individuals older than 50 years may be at risk of insulin resistance.
Some researchers suggested that the widespread insulin resistance in the US may be a result of the promotion of the Western diet over the past few decades.
Dr. Merat S, in the examination of the Western-type diets in the risk of insulin resistance, said, "the Western diets commonly used in LDLR-/- mice may not only induce atherosclerosis, but also IR, potentially complicating the interpretation of results".
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine for as liver protective and detoxified agents, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on the finding a natural therapeutics for the treatment of diabetes investigated the artichoke leaves extract on metabolic disorders and oxidative stress in alloxan-diabetic rats.
The study included 40 male Wistar rats induced diabetes with a single dose intraperitoneal injection (i.p.) of alloxan (150 mg/kg body weight (b.w.)) randomly assigned to orally and daily administrated of ethanol extract from C. scolymus at two doses (200-400 mg/kg, b.w) or (12 mg/kg, b.w).
According to the tested assays, the ethanol extract from leaves of C. scolymus showed the highest antioxidant activity and endowed the powerful inhibition in vitro of α-amylase activity with IC50=72,22 ug/uL.
In vivo, the ethanol extract from the leaves of C. scolymus (200-400 mg/kg) decreased significantly the levels of α-amylase enzymes involved in the digestion of carbohydrates in the serum of diabetic rats.
Furthermore, the administration of ethanol extract improved the anti-oxidative activity demonstrated by the increase of CAT, SOD and GSH activities in liver, kidney, and pancreas of diabetic rats.
Compared to diabetic rats, the ethanol extract from leaves of C. scolymus also decreased blood glucose rate, plasma total cholesterol (T-Ch) and triglyceride (TG) and low-density lipoproteins (LDL-C) after 28 days of treatment.
Researchers after taking into account other factors said, "These observed strongly suggest that ethanol extract from the leaves of C. scolymus has anti-hyperglycemic properties, at least partly mediated by antioxidant and hypolipidemic effects".
In order to reveal additional information about artichoke antidiabetic property, researchers in the joint study lead by the Hallym University examined the Jerusalem artichoke inhibitory activity against α-glucosidase and fasting serum glucose levels.
In a non-insulin-dependent diabetes mellitus animal model (C57BIKsJ db/db) selected for the study, water extract of PJA fermented by L. plantarum, and two strains of Bacillus subtilis injection showed the highest α-glucosidase inhibitory activity in vitro, compared to original Jerusalem artichoke (PJA).
PJA fermentation group significantly lower blood glucose concentration than the control.
At the end of 7 weeks, PJA fermentation group also induced higher levels of serum insulin and HDL cholesterol levels and lower the concentrations of triglycerides, non-esterified fatty acids, and total cholesterol.
Additionally, the intestinal α-glucosidase activity was partially inhibited by the PJA fermentation injection.
Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of diabetes with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Protective effects of Cynara scolymus leaves extract on metabolic disorders and oxidative stress in alloxan-diabetic rats by Ben Salem M1, Ben Abdallah Kolsi R2, Dhouibi R1, Ksouda K1, Charfi S3, Yaich M4, Hammami S1, Sahnoun Z1, Zeghal KM1, Jamoussi K4, Affes H. (PubMed)
(2) Fermentation of purple Jerusalem artichoke extract to improve the α-glucosidase inhibitory effect in vitro and ameliorate blood glucose in db/db mice by Wang Z1, Hwang SH1, Lee SY2, Lim SS. (PubMed)
The insulin receptor sites processed a function that binds the insulin and passes the message into the cell, leading to the transformation of glucose from the blood to energy.
The hallmark of diabetes is insulin resistance. The condition has been found to increase the risk of cardiovascular disease even without the presence of diabetes.
The exact causes of insulin resistance are unknown. However, some researchers suggested that genetic preposition and lifestyle are major risk factors that cause the onset of the syndrome.
According to the statistics, in the US, between 60 to 70 million individuals are affected by insulin resistance. More than 40% of individuals older than 50 years may be at risk of insulin resistance.
Some researchers suggested that the widespread insulin resistance in the US may be a result of the promotion of the Western diet over the past few decades.
Dr. Merat S, in the examination of the Western-type diets in the risk of insulin resistance, said, "the Western diets commonly used in LDLR-/- mice may not only induce atherosclerosis, but also IR, potentially complicating the interpretation of results".
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine for as liver protective and detoxified agents, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on the finding a natural therapeutics for the treatment of diabetes investigated the artichoke leaves extract on metabolic disorders and oxidative stress in alloxan-diabetic rats.
The study included 40 male Wistar rats induced diabetes with a single dose intraperitoneal injection (i.p.) of alloxan (150 mg/kg body weight (b.w.)) randomly assigned to orally and daily administrated of ethanol extract from C. scolymus at two doses (200-400 mg/kg, b.w) or (12 mg/kg, b.w).
According to the tested assays, the ethanol extract from leaves of C. scolymus showed the highest antioxidant activity and endowed the powerful inhibition in vitro of α-amylase activity with IC50=72,22 ug/uL.
In vivo, the ethanol extract from the leaves of C. scolymus (200-400 mg/kg) decreased significantly the levels of α-amylase enzymes involved in the digestion of carbohydrates in the serum of diabetic rats.
Furthermore, the administration of ethanol extract improved the anti-oxidative activity demonstrated by the increase of CAT, SOD and GSH activities in liver, kidney, and pancreas of diabetic rats.
Compared to diabetic rats, the ethanol extract from leaves of C. scolymus also decreased blood glucose rate, plasma total cholesterol (T-Ch) and triglyceride (TG) and low-density lipoproteins (LDL-C) after 28 days of treatment.
Researchers after taking into account other factors said, "These observed strongly suggest that ethanol extract from the leaves of C. scolymus has anti-hyperglycemic properties, at least partly mediated by antioxidant and hypolipidemic effects".
In order to reveal additional information about artichoke antidiabetic property, researchers in the joint study lead by the Hallym University examined the Jerusalem artichoke inhibitory activity against α-glucosidase and fasting serum glucose levels.
In a non-insulin-dependent diabetes mellitus animal model (C57BIKsJ db/db) selected for the study, water extract of PJA fermented by L. plantarum, and two strains of Bacillus subtilis injection showed the highest α-glucosidase inhibitory activity in vitro, compared to original Jerusalem artichoke (PJA).
PJA fermentation group significantly lower blood glucose concentration than the control.
At the end of 7 weeks, PJA fermentation group also induced higher levels of serum insulin and HDL cholesterol levels and lower the concentrations of triglycerides, non-esterified fatty acids, and total cholesterol.
Additionally, the intestinal α-glucosidase activity was partially inhibited by the PJA fermentation injection.
Taken altogether, artichoke may be considered a functional remedy for the prevention and treatment of diabetes with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Protective effects of Cynara scolymus leaves extract on metabolic disorders and oxidative stress in alloxan-diabetic rats by Ben Salem M1, Ben Abdallah Kolsi R2, Dhouibi R1, Ksouda K1, Charfi S3, Yaich M4, Hammami S1, Sahnoun Z1, Zeghal KM1, Jamoussi K4, Affes H. (PubMed)
(2) Fermentation of purple Jerusalem artichoke extract to improve the α-glucosidase inhibitory effect in vitro and ameliorate blood glucose in db/db mice by Wang Z1, Hwang SH1, Lee SY2, Lim SS. (PubMed)
Herbal Butterbur, the Potent Anti Seasonal Allergic Rhinitis Functional Herb, Scientists Suggest
Herbal Butterbur may be considered an adjunct therapy for the prevention and treatment of seasonal allergic rhinitis, some scientists suggested.
Seasonal allergic rhinitis is a condition of inflammation of the nasal passages as a result of seasonal allergic effects.
Most cases of rhinitis are caused by the immune system overreaction of pollen, mold, animal dander, or dust, the body releases chemicals.
Most people with acute allergic rhinitis are experiencing symptoms of sneezing, itchiness and a blocked or a runny nose.
However, some people may have chronic allergic rhinitis, because they're sensitive to all seasonal allergens, including tree or grass pollen.
Most acute allergic rhinitis does not require medical attention, however, if your acute allergic rhinitis that lasts for several months and disrupts your daily activity, you may want to check with your doctor to rule out other possibilities.
Longterm untreated allergic rhinitis may induce complications of nasal polyps, sinusitis, and middle ear infections.
Most cases of allergic rhinitis can be treated with over counter medicine, including non-sedating antihistamines and nasal passages spray with a saltwater solution.
In a severe case, a stronger medication, such as a nasal spray containing corticosteroids can be helpful.
Please make sure that you know all the side effects of corticosteroids for preventive measures.
Butterbur, found in wet, marshy, damp land, including wetland, riverside, forest, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belonging to the family Asteraceae, native to Northern Hemisphere.
The plant has been used in herbal medicine used as a pain reliever in the digestive system, including stomach, bile ducts, and duodenum, etc.
The Chemical ingredients of Butterbur include Petioles, petasitene, and ethylene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petasin and iso-S-petasin, etc.
In the study to re-examine the recent literature regarding the alternative therapies for the treatment of allergic rhinitis, Dr. Man LX, at the University of Pittsburgh School of Medicine, found that although there are several studies report beneficial effects of Butterbur for treating allergic rhinitis. additional insight into the mechanisms of action, short-term and long-term effects and adverse events are necessary before the herbal medicine can be integrated into the general treatment armamentarium of allergic rhinitis.
Dr. Guo R, the lead author in the study to investigate the efficacy of herbal medicines for the treatment of allergic rhinitis (AR) launched a search in the 5 electronic databases published before and on November 8, 2005.
The guideline and criteria were set to only include double-blind randomized clinical trials (RCTs), which tested a herbal medicine against placebo or an active comparator, in patients with AR, and evaluated clinically relevant outcomes.
Study selection, data extraction, and evaluation of methodological quality were performed independently by 2 reviewers.
16 eligible RCTs, testing 10 different herbal products against placebo or an active comparator, were included.
Out of 16 selected studies, Six RCTs studied suggested that Petasites hybridus (butterbur) extract is superior to placebo or similarly effective compared with nonsedative antihistamines for intermittent AR.
At the final report of the study, the doctors wrote, "There is encouraging evidence suggesting that P hybridus may be an effective herbal treatment for seasonal (intermittent) AR".
These results suggested that herbal Butterbur may be considered a functional herb for the prevention and treatment of seasonal allergic rhinitis without inducing serious side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Conventional, complementary, and alternative options for seasonal allergies by Moyad MA. (PubMed)
(2) Complementary and alternative medicine for allergic rhinitis by Man LX. (PubMed)
(3) Herbal medicines for the treatment of allergic rhinitis: a systematic review by Guo R, Pittler MH, Ernst E.(PubMed)
Seasonal allergic rhinitis is a condition of inflammation of the nasal passages as a result of seasonal allergic effects.
Most cases of rhinitis are caused by the immune system overreaction of pollen, mold, animal dander, or dust, the body releases chemicals.
Most people with acute allergic rhinitis are experiencing symptoms of sneezing, itchiness and a blocked or a runny nose.
However, some people may have chronic allergic rhinitis, because they're sensitive to all seasonal allergens, including tree or grass pollen.
Most acute allergic rhinitis does not require medical attention, however, if your acute allergic rhinitis that lasts for several months and disrupts your daily activity, you may want to check with your doctor to rule out other possibilities.
Longterm untreated allergic rhinitis may induce complications of nasal polyps, sinusitis, and middle ear infections.
Most cases of allergic rhinitis can be treated with over counter medicine, including non-sedating antihistamines and nasal passages spray with a saltwater solution.
In a severe case, a stronger medication, such as a nasal spray containing corticosteroids can be helpful.
Please make sure that you know all the side effects of corticosteroids for preventive measures.
Butterbur, found in wet, marshy, damp land, including wetland, riverside, forest, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belonging to the family Asteraceae, native to Northern Hemisphere.
The plant has been used in herbal medicine used as a pain reliever in the digestive system, including stomach, bile ducts, and duodenum, etc.
The Chemical ingredients of Butterbur include Petioles, petasitene, and ethylene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petasin and iso-S-petasin, etc.
In the study to re-examine the recent literature regarding the alternative therapies for the treatment of allergic rhinitis, Dr. Man LX, at the University of Pittsburgh School of Medicine, found that although there are several studies report beneficial effects of Butterbur for treating allergic rhinitis. additional insight into the mechanisms of action, short-term and long-term effects and adverse events are necessary before the herbal medicine can be integrated into the general treatment armamentarium of allergic rhinitis.
Dr. Guo R, the lead author in the study to investigate the efficacy of herbal medicines for the treatment of allergic rhinitis (AR) launched a search in the 5 electronic databases published before and on November 8, 2005.
The guideline and criteria were set to only include double-blind randomized clinical trials (RCTs), which tested a herbal medicine against placebo or an active comparator, in patients with AR, and evaluated clinically relevant outcomes.
Study selection, data extraction, and evaluation of methodological quality were performed independently by 2 reviewers.
16 eligible RCTs, testing 10 different herbal products against placebo or an active comparator, were included.
Out of 16 selected studies, Six RCTs studied suggested that Petasites hybridus (butterbur) extract is superior to placebo or similarly effective compared with nonsedative antihistamines for intermittent AR.
At the final report of the study, the doctors wrote, "There is encouraging evidence suggesting that P hybridus may be an effective herbal treatment for seasonal (intermittent) AR".
These results suggested that herbal Butterbur may be considered a functional herb for the prevention and treatment of seasonal allergic rhinitis without inducing serious side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Conventional, complementary, and alternative options for seasonal allergies by Moyad MA. (PubMed)
(2) Complementary and alternative medicine for allergic rhinitis by Man LX. (PubMed)
(3) Herbal medicines for the treatment of allergic rhinitis: a systematic review by Guo R, Pittler MH, Ernst E.(PubMed)
Monday, February 10, 2020
Herbal Chamomile, the Anti Skin Cancer Herbal Remedy
Chamomile processed a high amount of antioxidants may have a profound and positive effect on reducing the risk and treatment of skin cancer, according to studies.
Skin cancer is the medical condition caused by irregular cell growth in the skin tissues due to the alternation of cell DNA.
Most cases of skin cancer begin in the cell on the surface of the inner lining of skin tissues. However, at the advanced stage, the tumor cells can travel a distance away from the skin to infect other healthy tissue and organs, through lymph and blood, leading to secondary metastasis.
Organs or system which is vulnerable to skin metastasis is lymph, lung, and liver.
Although family and personal history, history of sunburn, excessive sun exposure and people who live in sunny or high-altitude climates are associated with the risks of skin cancer, some researchers suggested that skin cancer in the Western world may be attributed to the misunderstanding the risk of sun exposure and the risk of unhealthy skin, as we still can see a lots of naked skin exposed to sunlight during the Summer months in the parks.
According to the statistic, 90 percent of nonmelanoma skin cancers are associated with exposure to ultraviolet (UV) radiation from the sun. An estimated 4.3 million cases of BCC are diagnosed in the U.S. each year. causing the death of more than 3,000 people.
Dr. Honnavara N Ananthaswamy in the concern of the sunlight and risk of skin cancer wrote, " Laboratory studies have shown that UV-B region of the solar spectrum is responsible for this effect. The first step in UV skin carcinogenesis involves the induction of DNA damage".
And, "Occasional mistakes during the repair of this damage leads to the incorporation of wrong bases into the genetic material. The DNA damage that is left unrepaired may also disrupt cellular processes by obstructing the DNA and RNA synthesizing machineries and introduce the wrong bases into the DNA. These types of mistakes often result in mutation leading to loss or inappropriate expression of affected genes".
The finding indicated the progression of skin cancer in long-term UV exposure and how the UV light induces the change of skin cells' DNA.
Chamomile is also known as camomile, the common name of many species daisy-like plants in the family Asteraceae. The herb has been used in traditional medicine as antispasmodic and anti-inflammatory constituents and for the treatment of menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.
Researchers on finding a herbal medicine for the treatment of skin cancer which not only continues to rise but also accounts for approximately 40% of all cancers reported in the United States and 9,500 deaths per year, examined the effects of chamomile against reactive oxygen species (ROS) type free radicals in the initiation of skin cancer and aging.
Compared to other herbal medicines used in the study, chamomile demonstrated skin protective effects against oxidative stress through its antioxidant activity.
In vitro, chamomile modulated the hydrogen peroxide (H2O2)-induced upregulation of ROS free radicals in normal human skin fibroblasts.
According to the flow cytometry-based assay, the free radical inhibition of chamomile was attributed to a single ingredient but varying concentrations of herbal chamomile natural components.
Additional investigation of the chamomile anti-skin cancer activity, researchers examined the bioactive compound Apigenin, the major active compound from herbal chamomile which was previously found to inhibit chemically induced ornithine decarboxylase (ODC) activity and skin tumor promotion.
Increased ornithine decarboxylase (ODC) was associated with the expression of oxidative stress in animal chemical induction.
After mouse skin carcinogenesis was induced by exposure to a total dose of 40 J/cm2 UVB over 11 weeks, application of Apigenin (5 mumoles/200 microliters DMSO:acetone, 1:9) treatment from 12 hours before until 1 hour following UVA/B exposure was effective in inhibition (25-45% inhibition) of ODC activity measured at 28 hours following UVA/B exposure.
Treatment with 10 mumoles apigenin in 200 microliters DMSO:acetone (1:9) prior to each UVB exposure showed a reduction in cancer incidence (52% inhibition) and an increase in tumor-free survival, compared to control mice.
Interestingly, in salmon sperm, Apigenin (0-100 microM) did not prevent the production of photoproducts to cause damage to the cell DNA.
The results strongly suggested that Apigenin inhibited UVA/B induced ODC activity or UVB induced skin carcinogenesis through many unknown mechanisms instead of simply absorbing ultraviolet light or decreasing DNA damage.
Taken altogether, herbal chamomile may be considered a functional remedy for the prevention and combined with primary medicine for the treatment of skin cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The active natural anti-oxidant properties of chamomile, milk thistle, and halophilic bacterial components in human skin in vitro by Mamalis A1, Nguyen DH, Brody N, Jagdeo J.(PubMed)
(2) Inhibition of ultraviolet light induced skin carcinogenesis in SKH-1 mice by apigenin, a plant flavonoid by Birt DF1, Mitchell D, Gold B, Pour P, Pinch HC.(PubMed)
(3) Suppression of protein kinase C and nuclear oncogene expression as possible molecular mechanisms of cancer chemoprevention by apigenin and curcumin by Lin JK1, Chen YC, Huang YT, Lin-Shiau SY.(PubMed)
(4) Sunlight and skin cancer by Honnavara N Ananthaswamy. (PMC)
Skin cancer is the medical condition caused by irregular cell growth in the skin tissues due to the alternation of cell DNA.
Most cases of skin cancer begin in the cell on the surface of the inner lining of skin tissues. However, at the advanced stage, the tumor cells can travel a distance away from the skin to infect other healthy tissue and organs, through lymph and blood, leading to secondary metastasis.
Organs or system which is vulnerable to skin metastasis is lymph, lung, and liver.
Although family and personal history, history of sunburn, excessive sun exposure and people who live in sunny or high-altitude climates are associated with the risks of skin cancer, some researchers suggested that skin cancer in the Western world may be attributed to the misunderstanding the risk of sun exposure and the risk of unhealthy skin, as we still can see a lots of naked skin exposed to sunlight during the Summer months in the parks.
According to the statistic, 90 percent of nonmelanoma skin cancers are associated with exposure to ultraviolet (UV) radiation from the sun. An estimated 4.3 million cases of BCC are diagnosed in the U.S. each year. causing the death of more than 3,000 people.
Dr. Honnavara N Ananthaswamy in the concern of the sunlight and risk of skin cancer wrote, " Laboratory studies have shown that UV-B region of the solar spectrum is responsible for this effect. The first step in UV skin carcinogenesis involves the induction of DNA damage".
And, "Occasional mistakes during the repair of this damage leads to the incorporation of wrong bases into the genetic material. The DNA damage that is left unrepaired may also disrupt cellular processes by obstructing the DNA and RNA synthesizing machineries and introduce the wrong bases into the DNA. These types of mistakes often result in mutation leading to loss or inappropriate expression of affected genes".
The finding indicated the progression of skin cancer in long-term UV exposure and how the UV light induces the change of skin cells' DNA.
Chamomile is also known as camomile, the common name of many species daisy-like plants in the family Asteraceae. The herb has been used in traditional medicine as antispasmodic and anti-inflammatory constituents and for the treatment of menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.
Researchers on finding a herbal medicine for the treatment of skin cancer which not only continues to rise but also accounts for approximately 40% of all cancers reported in the United States and 9,500 deaths per year, examined the effects of chamomile against reactive oxygen species (ROS) type free radicals in the initiation of skin cancer and aging.
Compared to other herbal medicines used in the study, chamomile demonstrated skin protective effects against oxidative stress through its antioxidant activity.
In vitro, chamomile modulated the hydrogen peroxide (H2O2)-induced upregulation of ROS free radicals in normal human skin fibroblasts.
According to the flow cytometry-based assay, the free radical inhibition of chamomile was attributed to a single ingredient but varying concentrations of herbal chamomile natural components.
Additional investigation of the chamomile anti-skin cancer activity, researchers examined the bioactive compound Apigenin, the major active compound from herbal chamomile which was previously found to inhibit chemically induced ornithine decarboxylase (ODC) activity and skin tumor promotion.
Increased ornithine decarboxylase (ODC) was associated with the expression of oxidative stress in animal chemical induction.
After mouse skin carcinogenesis was induced by exposure to a total dose of 40 J/cm2 UVB over 11 weeks, application of Apigenin (5 mumoles/200 microliters DMSO:acetone, 1:9) treatment from 12 hours before until 1 hour following UVA/B exposure was effective in inhibition (25-45% inhibition) of ODC activity measured at 28 hours following UVA/B exposure.
Treatment with 10 mumoles apigenin in 200 microliters DMSO:acetone (1:9) prior to each UVB exposure showed a reduction in cancer incidence (52% inhibition) and an increase in tumor-free survival, compared to control mice.
Interestingly, in salmon sperm, Apigenin (0-100 microM) did not prevent the production of photoproducts to cause damage to the cell DNA.
The results strongly suggested that Apigenin inhibited UVA/B induced ODC activity or UVB induced skin carcinogenesis through many unknown mechanisms instead of simply absorbing ultraviolet light or decreasing DNA damage.
Taken altogether, herbal chamomile may be considered a functional remedy for the prevention and combined with primary medicine for the treatment of skin cancer.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) The active natural anti-oxidant properties of chamomile, milk thistle, and halophilic bacterial components in human skin in vitro by Mamalis A1, Nguyen DH, Brody N, Jagdeo J.(PubMed)
(2) Inhibition of ultraviolet light induced skin carcinogenesis in SKH-1 mice by apigenin, a plant flavonoid by Birt DF1, Mitchell D, Gold B, Pour P, Pinch HC.(PubMed)
(3) Suppression of protein kinase C and nuclear oncogene expression as possible molecular mechanisms of cancer chemoprevention by apigenin and curcumin by Lin JK1, Chen YC, Huang YT, Lin-Shiau SY.(PubMed)
(4) Sunlight and skin cancer by Honnavara N Ananthaswamy. (PMC)
Chaste Tree Berry's Estrogenic Effects
Chaste-tree berry (Vitex agnus-castus L.) displaced estrogenic ability induced the reaction of estrogen from the binding site of estrogen receptors alpha (ERalpha) and beta (ERbeta), in ameliorated the deregulation of 17β-Estradiol (E2) in exhibited the initiation and progression of cell malignancies, affecting various aspect in women body, a study by respectable Institute suggested.
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.
According to the University of Illinois at Chicago, linoleic acid isolated from the extract of Vitex agnus-castus exerted estrogenic activity in binding to estrogen receptors, inducing certain estrogen-inducible gene expression in preserving the integrity of the genome, presented in a cell or organism.
Dr. Jarry H, the lead author in the study of "evidence for estrogen receptor beta-selective activity of Vitex agnus-castus and isolated flavones" found that beside linoleic acid, flavones derivative vitexin and penduletin. isolated from vitex agnus-castus (VAC) also expressed estrogenic effect as most active ERss-selective phytoestrogens.
Other researchers insisted that the estrogenic components of plant extracts may constitute a potential use for some dietary supplements in human for treatment of various estrogen related syndromes and diseases, including breast and prostate cancers, menopausal symptoms, osteoporosis, atherosclerosis and stroke, and neurodegeneration.
Taking together, Chaste tree berry processes a strong estrogenic effects in binding estrogen receptor site to preserve the balancing of hormone expression of estrogen through ER alpha and ERBeta inhibition and exhibition by regulating the function of some estrogen-inducible genes.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months
Sources
(1) Isolation of linoleic acid as an estrogenic compound from the fruits of Vitex agnus-castus L. (chaste-berry) by Liu J1, Burdette JE, Sun Y, Deng S, Schlecht SM, Zheng W, Nikolic D, Mahady G, van Breemen RB, Fong HH, Pezzuto JM, Bolton JL, Farnsworth NR.(PubMed)
(2) Evidence for estrogen receptor beta-selective activity of Vitex agnus-castus and isolated flavones by Jarry H1, Spengler B, Porzel A, Schmidt J, Wuttke W, Christoffel V.(PubMed)
(3) Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms by Liu J1, Burdette JE, Xu H, Gu C, van Breemen RB, Bhat KP, Booth N, Constantinou AI, Pezzuto JM, Fong HH, Farnsworth NR, Bolton JL.(PubMed)
(4) Health effects of phytoestrogens by Branca F1, Lorenzetti S.(PubMed)
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