Chaste Tree Berry's Estrogenic Effects

Chaste-tree berry (Vitex agnus-castus L.) displaced estrogenic ability induced the reaction of estrogen from the binding site of estrogen receptors alpha (ERalpha) and beta (ERbeta), in ameliorated the deregulation of 17β-Estradiol (E2) in exhibited the initiation and progression of cell malignancies, affecting various aspect in women body, a study by respectable Institute suggested.


Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of year as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.
According to the University of Illinois at Chicago, linoleic acid isolated from the extract of Vitex agnus-castus exerted estrogenic activity in binding to estrogen receptors, inducing certain estrogen-inducible gene expression in preserving the integrity of the genome, presented in a cell or organism.


Dr. Jarry H, the lead author in the study of "evidence for estrogen receptor beta-selective activity of Vitex agnus-castus and isolated flavones" found that beside linoleic acid, flavones derivative vitexin and penduletin. isolated from vitex agnus-castus (VAC) also expressed estrogenic effect as most active ERss-selective phytoestrogens.


Other researchers insisted that the estrogenic components of plant extracts may constitute a potential use for some dietary supplements in human for treatment of various estrogen related syndromes and diseases, including breast and prostate cancers, menopausal symptoms, osteoporosis, atherosclerosis and stroke, and neurodegeneration.

Taking together, Chaste tree berry processes a strong estrogenic effects in binding estrogen receptor site to preserve the balancing of hormone expression of estrogen through ER alpha and ERBeta inhibition and exhibition by regulating the function of some estrogen-inducible genes.


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Sources
(1) Isolation of linoleic acid as an estrogenic compound from the fruits of Vitex agnus-castus L. (chaste-berry) by Liu J1, Burdette JE, Sun Y, Deng S, Schlecht SM, Zheng W, Nikolic D, Mahady G, van Breemen RB, Fong HH, Pezzuto JM, Bolton JL, Farnsworth NR.(PubMed)
(2) Evidence for estrogen receptor beta-selective activity of Vitex agnus-castus and isolated flavones by Jarry H1, Spengler B, Porzel A, Schmidt J, Wuttke W, Christoffel V.(PubMed)
(3) Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms by Liu J1, Burdette JE, Xu H, Gu C, van Breemen RB, Bhat KP, Booth N, Constantinou AI, Pezzuto JM, Fong HH, Farnsworth NR, Bolton JL.(PubMed)
(4) Health effects of phytoestrogens by Branca F1, Lorenzetti S.(PubMed)