Cancer is a group of medical and chronic diseases characterized by cell growth disorderly and uncontrollably in the tissue of specific organs in the body.
Over time, the alternative cells induced tumor may become progressively worse and damage other healthy tissues, depending on the grade of the tumor.
At the later stage, the most invasive tumor can induce secondary metastasis by spreading to other organs in the body via lymph or blood.
According to the National Cancer Institute, approximately 38.4% of men and women will be diagnosed with cancer at some points during their lifetimes, according to the data from 2013–2015.
In 2017, an estimated 15,270 children and adolescents ages 0 to 19 were diagnosed with cancer and 1,790 died of the disease.
The cancer cytotoxicity is an activity to cause the destruction of cancer cells by causing cancer cell apoptosis
Cytotoxic activity is a process to induce toxic to cells.
Cramp Bark is an ornamental plant, genus Viburnum, belonging to the family Adoxaceae, native to Europe and Asia. It has been used in traditional and herbal medicine as anti-spasmodic, anti-inflammatory, nervine. hypotensive agent and to treat menstrual cramps and pain, afterbirth, postpartum pains, excessive blood loss in periods, bleeding associated with the menopause, etc.
On finding a potential herbal medicine for the prevention and treatment of cancer, researchers examined the effects of Cramp Bark(Viburnum opulus) extract cytoprotective activity on Caco-2 cell, the continuous line of heterogeneous human epithelial colorectal adenocarcinoma cells.
According to the tested analysis, the extract showed a strong anti-tumor property in modulating the cellular membrane dynamic in the progression of the cancer cells.
Furthermore, the application exerted a strong chemo-preventive activity against oxidative stress-induced chemically by tert-butyl hydroperoxide (t-BOOH).
Moreover, the antioxidants activity of the extract also inhibits DNA damage by initiating the DNA self-repair after cell exposition to reactive oxygen species, methylnitronitrosoguanidine (MNNG) and H2O2.
Taken altogether, cramp bark(Viburnum opulus) may be considered a functional herb which processes cytoprotective activity, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Viburnum opulus Fruit Phenolic Compounds as Cytoprotective Agents Able to Decrease Free Fatty Acids and Glucose Uptake by Caco-2 Cells by Zakłos-Szyda M1, Pawlik N2, Polka D2, Nowak A3, Koziołkiewicz M2, Podsędek A. (PubMed)
Saturday, March 14, 2020
Friday, March 13, 2020
Herbal Cleaver(Galium aparine), the Best Remedy for the Treatment of Hypertension
Blood pressure is the force of the blood pushing against the arterial walls. In high blood pressure, the heart has to work harder than normal to pump blood through the circulation system. Over time, high blood pressure has been found to cause damage to the heart and arteries.
Hypertension or high blood pressure is a condition characterized by persistent high blood pressure.
In the US approximately, one-third of the adults have high blood pressure, affecting over 77 million people in the country.
Additionally, among adults age 20 and older in the United States, in the non-Hispanic whites community, 33.4 percent of men and 30.7 percent of women are infected by the syndrome.
High blood pressure is a slowly developed condition. Unless the syndrome has caused damage to the blood vessel, otherwise symptoms cannot be detected.
The cause of high blood pressure is a result of hardening and thickening of the arteries (atherosclerosis), due to the slow progression of plaques accumulated on the wall of the arteries.
High blood pressure can be acute or chronic. Acute high blood pressure most often occurs to people with sudden stress.
Acute high blood pressure can be caused by intense physical exercise. As the heart must pump harder to provide the needs of nutrients and oxygen.
Most cases of chronic high blood pressure are associated with an unhealthy lifestyle and chronic diseases such as kidney disease, leading to the onset of strokes and cardiovascular disease.
Abnormal high blood pressure, depending on how high of the numbers, patients may experience symptoms of a headache to a severe headache., fatigue, vision problems. However, in severe cases, high blood pressure can also induce chest pain, difficulty breathing, irregular heartbeat and confusion.
Untreated high blood pressure epidemiologically can cause complications of retinopathy, lead to damage to the retina or bleeding in the eye, blurred vision and complete loss of vision.
Cleaver is a herbaceous annual plant, genus Galium, belonging to the family Rubiaceae, native to North America and Eurasia. The herb has been used over thousands of years in herbal and traditional medicine as mild diuretic and blood and lymphatic cleanser and to treat psoriasis, skin conditions, glands, tonsillitis, bladder infections, prevent small kidney stone, etc.
On finding a potential compound for the prevention and treatment of cardiovascular diseases (CVD), researchers investigated the antihypertensive and antioxidant potential of vanillic acid (VA) found in cleaver, in N(ω)-Nitro-L-arginine methyl ester hydrochloride (L-NAME) induced hypertension in adult male albino Wistar rats.
Before injecting vanillic acid, L-NAME (40 mg/kg Bw for 30 days) treated rats caused a sustained increase in systolic- (SBP) and diastolic blood pressure (DBP) and significantly decreased the concentration of nitrite/nitrate (NO(x)) in plasma, compared to the control.
However, rats treated with VA restored SBP and DBP to a normal level and preserved the plasma NO metabolites concentration.
Moreover, the VA also improved the antioxidant and non-antioxidant enzymes and lipid reduced lipid peroxidation expression in the plasma of the tested rats.
VA thiobarbituric acid reactive substances, lipid hydroperoxides, conjugated dienes) and significantly restored enzymatic antioxidants (superoxide dismutase, catalase, and glutathione peroxidase), non-enzymatic antioxidants (vitamin C, vitamin E, and reduced glutathione) in the plasma.
More precisely, the effect at a dose of 50 mg/kg Bw of VA was more pronounced than that of 25 and 100 mg/kg Bw.
Based on the findings, researchers said, " VA possesses an antihypertensive and antioxidant activity in L-NAME-induced hypertensive rats".
Taken altogether, Comfrey may be considered a remedy for the treatment of hypertension, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antihypertensive and antioxidant potential of vanillic acid, a phenolic compound in L-NAME-induced hypertensive rats: a dose-dependence study by Kumar S1, Prahalathan P, Raja B. (PubMed)
Hypertension or high blood pressure is a condition characterized by persistent high blood pressure.
In the US approximately, one-third of the adults have high blood pressure, affecting over 77 million people in the country.
Additionally, among adults age 20 and older in the United States, in the non-Hispanic whites community, 33.4 percent of men and 30.7 percent of women are infected by the syndrome.
High blood pressure is a slowly developed condition. Unless the syndrome has caused damage to the blood vessel, otherwise symptoms cannot be detected.
The cause of high blood pressure is a result of hardening and thickening of the arteries (atherosclerosis), due to the slow progression of plaques accumulated on the wall of the arteries.
High blood pressure can be acute or chronic. Acute high blood pressure most often occurs to people with sudden stress.
Acute high blood pressure can be caused by intense physical exercise. As the heart must pump harder to provide the needs of nutrients and oxygen.
Most cases of chronic high blood pressure are associated with an unhealthy lifestyle and chronic diseases such as kidney disease, leading to the onset of strokes and cardiovascular disease.
Abnormal high blood pressure, depending on how high of the numbers, patients may experience symptoms of a headache to a severe headache., fatigue, vision problems. However, in severe cases, high blood pressure can also induce chest pain, difficulty breathing, irregular heartbeat and confusion.
Untreated high blood pressure epidemiologically can cause complications of retinopathy, lead to damage to the retina or bleeding in the eye, blurred vision and complete loss of vision.
Cleaver is a herbaceous annual plant, genus Galium, belonging to the family Rubiaceae, native to North America and Eurasia. The herb has been used over thousands of years in herbal and traditional medicine as mild diuretic and blood and lymphatic cleanser and to treat psoriasis, skin conditions, glands, tonsillitis, bladder infections, prevent small kidney stone, etc.
On finding a potential compound for the prevention and treatment of cardiovascular diseases (CVD), researchers investigated the antihypertensive and antioxidant potential of vanillic acid (VA) found in cleaver, in N(ω)-Nitro-L-arginine methyl ester hydrochloride (L-NAME) induced hypertension in adult male albino Wistar rats.
Before injecting vanillic acid, L-NAME (40 mg/kg Bw for 30 days) treated rats caused a sustained increase in systolic- (SBP) and diastolic blood pressure (DBP) and significantly decreased the concentration of nitrite/nitrate (NO(x)) in plasma, compared to the control.
However, rats treated with VA restored SBP and DBP to a normal level and preserved the plasma NO metabolites concentration.
Moreover, the VA also improved the antioxidant and non-antioxidant enzymes and lipid reduced lipid peroxidation expression in the plasma of the tested rats.
VA thiobarbituric acid reactive substances, lipid hydroperoxides, conjugated dienes) and significantly restored enzymatic antioxidants (superoxide dismutase, catalase, and glutathione peroxidase), non-enzymatic antioxidants (vitamin C, vitamin E, and reduced glutathione) in the plasma.
More precisely, the effect at a dose of 50 mg/kg Bw of VA was more pronounced than that of 25 and 100 mg/kg Bw.
Based on the findings, researchers said, " VA possesses an antihypertensive and antioxidant activity in L-NAME-induced hypertensive rats".
Taken altogether, Comfrey may be considered a remedy for the treatment of hypertension, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antihypertensive and antioxidant potential of vanillic acid, a phenolic compound in L-NAME-induced hypertensive rats: a dose-dependence study by Kumar S1, Prahalathan P, Raja B. (PubMed)
Herbal Cramp Bark (Vib urnum opulus), the Anti-Endometriosis Functional Herb
Endometriosis is a painful disorder characterized by endometrial cells that grow in other areas in the reproductive organs, such as ovaries, fallopian tubes,..... and the tissue lining your pelvis, outside of the uterus.
Most cases of endometriosis are in the organs in the pelvic area, including ovaries and fallopian tubes.
Endometriosis also reacts to hormone signals of the monthly menstrual cycle, by building and breaking up tissues and eliminating them through the menstrual period.
According to the statistics provided by the Clinical Center of Niš,
* About 20% of reproductive-age women with endometriosis are asymptomatic
* About 55% of women have developed the new onset of severe menstrual cramps
* About 25% of women with sub-fertility (less fertile than a normal couple), depending on the stages of endometriosis.
Endometriosis can be classified into 4 stages
* Minimal stage
The top surface, few in number. Commonly they are found in the inside wall of uterus, ligaments, and ovary, causing a significant reduction in both progesterone and its ratio with 17 beta-oestradiol, luteal dysfunction and abnormal secretory patterns(3). Minimal stage endometriosis may lead to unexplained causes of infertility(2).
* Mild stage
Deeper implants, greater numbers are presented. Commonly found in the same area as a minimal stage, causing worsening of oocyte quality. The mild stage of endometriosis may lead to infertility(4).
* Moderate stage:
Many implants, endometrial cysts are presented, affecting ovary function, and causing scar tissues and adhesion.
* Severe stage:
Intensive peritoneal implants, large endometriomas are presented with dense adhesion.
Conventionally, most cases of endometriosis are treated by pain medicines such as NSAIDs (non-steroidal anti-inflammatory drugs) and hormone therapy such as birth control pills with an aim to reduce pain and improve quality of life, including daily activity.
Cramp Bark is an ornamental plant, genus Viburnum, belonging to the family Adoxaceae, native to Europe and Asia. It has been used in traditional and herbal medicine as anti-spasmodic, anti-inflammatory, nervine. hypotensive agent and to treat menstrual cramps and pain, afterbirth, postpartum pains, excessive blood loss in periods, bleeding associated with the menopause, etc.
On finding a potential herbal medicine for the treatment of menstrual disorders, researchers examined
the effects of cramp-bark on endometriosis in an animal model.
In the endometriosis induced by suturing 15mm piece of the endometrium into the abdominal wall of Sprague Dawley rats, air-dried, powdered fruits of V. Opulus extracts sequentially with n-hexane, ethyl acetate (EtOAc), and methanol (MeOH) showed a strong effect in reducing the endometriotic volumes.
In other words, the EtOAc and MeOH extract-administered group showed a decreased of endometrial volumes to 30.1mm3 and 34.7mm3, compared to the control group, respectively.
Furthermore, EtOAc groups showed no endometrial adhesion.
Moreover, according to the histopathological data both EtOAc and MeOH extract-administered groups displayed significant remission in the levels of pro-inflammatory cytokines, compared to control.
The chemical compound associated with the anti endometriosis activity was found to be chlorogenic acid, according to HPLC analysis.
Based on the results, researchers said, "the effectiveness of the fruit extract of V. Opulus could be partially attributed chlorogenic acid. Other phenolic compounds could potentiate the activity due to their amount".
Cramp Bark(Viburnum opulus) may be considered an anti endometriosis remedy, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Viburnum opulus L.: A remedy for the treatment of endometriosis demonstrated by rat model of surgically-induced endometriosis by Saltan G1, Süntar I2, Ozbilgin S1, Ilhan M2, Demirel MA3, Oz BE1, Keleş H4, Akkol EK. (PubMed)
Thursday, March 12, 2020
Herbal Cleaver(Galium aparine) Protects the Bone Density
Bone health is measured by bone mineral density which has a direct influence on the risk of osteoporosis and fractures.
There are numbers of bone diseases, including include osteoporosis, rickets, osteomalacia, osteogenesis imperfecta, marble bone disease (osteopetrosis), Paget disease of bone, and fibrous dysplasia.
And osteoporosis is the most frequent occurrence in the aging population.
Osteoporosis is a bone disease characterized by the inability of the body to produce bone to make up bone loss, leading the loss of bone density over a long period of time.
People with low bone density are susceptible to fracture, break from a fall due to bone weakening.
The exact causes of osteoporosis are unknown. However, researchers do know that certain preventable risk factors such as smoking, low calcium intake, physical inactivity, excessive alcohol consumption and unpreventable risk factors such as aging, family history, genders, race, body frame size,... and sedentary works are associated to increase the onset of the disease.
It is a widespread degenerative disease of skeletal joints and often associated with senescence invertebrates due to excessive or abnormal mechanical loading of weight-bearing joints, arising from heavy long-term use or specific injuries.
If you experience symptoms of lower back pain, loss of height over time, a stooped posture, easy bone fracture, neck and back pain,..., you may have osteoporosis.
Truly, bone diseases affected normal growth and development can lead to weakness and/or deformity.
The causes of bone diseases may be associated with genetic abnormalities, nutritional deficiencies, hormonal disorders, infections, cancers..... and other conditions.
According to the general belief and the recommendation of health researchers, good diet and physical exercise may play an important role in skeletal mass at the end of adolescence and these bone mass remain as the conservation of it during adult life(1).
Attending normal exercise and intake of bone enhancing food at young adult life may protect ourselves against the risk of bone diseases as we age.
Cleaver is a herbaceous annual plant, genus Galium, belonging to the family Rubiaceae, native to North America and Eurasia. The herb has been used over thousands of years in herbal and traditional medicine as mild diuretic and blood and lymphatic cleanser and to treat psoriasis, skin conditions, glands, tonsillitis, bladder infections, prevent small kidney stone, etc.
On finding a potential compound for the treatment of diseases associated with the loss of bone
density, researchers investigated hot component p-hydroxycinnamic acid (HCA) found abundantly in herbal cleaver effect on bone formation and an inhibitory effect on bone resorption in rat femoral tissues in vitro.
The study included diabetes rats induced bone loss by a single subcutaneous administration of STZ (6.0 mg/100 g body weight), following by orally administered HCA (0.25, 0.5, or 1.0 mg/100 g body weight) once daily for 14 days.
Before treatment with HCA, STZ administration showed a significant decrease in body weight and parameters associated with diabetes, including the increase in serum glucose, triglyceride, and calcium levels.
However, the alterations were significantly prevented by the administration of HCA (0.25, 0.5, or 1.0 mg/100 g).
Furthermore, bone density loss was also found in the STZ-diabetic rats observed by the significantly lower calcium content in the femoral-diaphyseal and -metaphyseal tissues which were also prevented after administration of HCA (0.25, 0.5, or 1.0 mg/100 g).
Moreover, the decline of the levels of Alkaline phosphatase activity associated with bone formation in the diaphyseal and metaphyseal tissues in STZ-diabetic rats was significantly prevented after the administration of HCA (0.5 and 1.0 mg/l00 g).
Additionally, administration of HCA (0.25, 0.5, or 1.0 mg/100 g) caused a significant increase in DNA content in the diaphyseal and metaphyseal tissues that were significantly decreased in STZ-diabetic rats.
Based on the findings, researchers said, " the intake of HCA has preventive effects on bone loss in STZ-diabetic rats, and that the intake has partially restorative effects on serum biochemical findings in the diabetic state".
Taken altogether, herbal cleaver processed a high amount of HCA may be considered an anti bone loss remedy, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Oral administration of phytocomponent p-hydroxycinnamic acid has a preventive effect on bone loss in streptozotocin-induced diabetic rats by Yamaguchi M1, Uchiyama S, Lai YL. (PubMed)
There are numbers of bone diseases, including include osteoporosis, rickets, osteomalacia, osteogenesis imperfecta, marble bone disease (osteopetrosis), Paget disease of bone, and fibrous dysplasia.
And osteoporosis is the most frequent occurrence in the aging population.
Osteoporosis is a bone disease characterized by the inability of the body to produce bone to make up bone loss, leading the loss of bone density over a long period of time.
People with low bone density are susceptible to fracture, break from a fall due to bone weakening.
The exact causes of osteoporosis are unknown. However, researchers do know that certain preventable risk factors such as smoking, low calcium intake, physical inactivity, excessive alcohol consumption and unpreventable risk factors such as aging, family history, genders, race, body frame size,... and sedentary works are associated to increase the onset of the disease.
It is a widespread degenerative disease of skeletal joints and often associated with senescence invertebrates due to excessive or abnormal mechanical loading of weight-bearing joints, arising from heavy long-term use or specific injuries.
If you experience symptoms of lower back pain, loss of height over time, a stooped posture, easy bone fracture, neck and back pain,..., you may have osteoporosis.
Truly, bone diseases affected normal growth and development can lead to weakness and/or deformity.
The causes of bone diseases may be associated with genetic abnormalities, nutritional deficiencies, hormonal disorders, infections, cancers..... and other conditions.
According to the general belief and the recommendation of health researchers, good diet and physical exercise may play an important role in skeletal mass at the end of adolescence and these bone mass remain as the conservation of it during adult life(1).
Attending normal exercise and intake of bone enhancing food at young adult life may protect ourselves against the risk of bone diseases as we age.
Cleaver is a herbaceous annual plant, genus Galium, belonging to the family Rubiaceae, native to North America and Eurasia. The herb has been used over thousands of years in herbal and traditional medicine as mild diuretic and blood and lymphatic cleanser and to treat psoriasis, skin conditions, glands, tonsillitis, bladder infections, prevent small kidney stone, etc.
On finding a potential compound for the treatment of diseases associated with the loss of bone
density, researchers investigated hot component p-hydroxycinnamic acid (HCA) found abundantly in herbal cleaver effect on bone formation and an inhibitory effect on bone resorption in rat femoral tissues in vitro.
The study included diabetes rats induced bone loss by a single subcutaneous administration of STZ (6.0 mg/100 g body weight), following by orally administered HCA (0.25, 0.5, or 1.0 mg/100 g body weight) once daily for 14 days.
Before treatment with HCA, STZ administration showed a significant decrease in body weight and parameters associated with diabetes, including the increase in serum glucose, triglyceride, and calcium levels.
However, the alterations were significantly prevented by the administration of HCA (0.25, 0.5, or 1.0 mg/100 g).
Furthermore, bone density loss was also found in the STZ-diabetic rats observed by the significantly lower calcium content in the femoral-diaphyseal and -metaphyseal tissues which were also prevented after administration of HCA (0.25, 0.5, or 1.0 mg/100 g).
Moreover, the decline of the levels of Alkaline phosphatase activity associated with bone formation in the diaphyseal and metaphyseal tissues in STZ-diabetic rats was significantly prevented after the administration of HCA (0.5 and 1.0 mg/l00 g).
Additionally, administration of HCA (0.25, 0.5, or 1.0 mg/100 g) caused a significant increase in DNA content in the diaphyseal and metaphyseal tissues that were significantly decreased in STZ-diabetic rats.
Based on the findings, researchers said, " the intake of HCA has preventive effects on bone loss in STZ-diabetic rats, and that the intake has partially restorative effects on serum biochemical findings in the diabetic state".
Taken altogether, herbal cleaver processed a high amount of HCA may be considered an anti bone loss remedy, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Oral administration of phytocomponent p-hydroxycinnamic acid has a preventive effect on bone loss in streptozotocin-induced diabetic rats by Yamaguchi M1, Uchiyama S, Lai YL. (PubMed)
Herbal Dandelion (Taraxacum officinale) Inhibits the Progression of Rheumatoid Arthritis (RA)
Arthritis, one of the Musculoskeletal disorders (MSDs) degenerative disease, is a general term of joint inflammation, affecting over 21% of the US population.
There are over 100 different forms of arthritis and related diseases. Rheumatoid arthritis (RA), is the common form of arthritis involved in chronic low-grade inflammation.
Juvenile arthritis is an inflammatory disease affecting the synovium in children aged 16 or younger.
In other words, it is an autoimmune disorder caused by the immune system attacks some of the body's own healthy cells and tissues, in this case, the immune system attacks the joint tissue in the juvenile.
that are associated with the risk of juvenile idiopathic arthritis include HLA-A. HLA-B. HLA-DPB1. HLA-DQA1. HLA-DQB1. HLA-DRB1. IL2RA. IL6, according to the National Institute of Health.
According to the statistic, the most common form of juvenile idiopathic arthritis (JIA), affects over 50,000 children in the United States alone.
Rheumatoid Arthritis (RA) is a type of arthritis associated with inflammation that affects mostly the flexible (synovial) joints and tissues and organs in the body.
The disease affects more women than men and generally occurs after the ages of 40, causing the diminished quality of life of many older adults.
According to the CDC, musculoskeletal disorders (MSDs) affect over 52 million adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions.
Rheumatoid Arthritis can induce bone loss through elevating bone resorption without increasing bone formation.
A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes.
Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.
On finding a natural ingredient for the treatment of chronic inflammatory diseases, scientists examined taraxasterol (TAR), a bioactive active compound pentacyclic triterpenes isolated from Chinese medicine herb Taraxacum officinale effects on rheumatoid arthritis (RA).
In Vitro and Vivo, the application of TRA significantly suppressed the proteins involved in the production of pro-inflammatory cytokines, namely tumor necrosis factor-α (TNF-α), IL-6, and IL-8 by blocking NOD-like receptor protein 3 (NLRP3) inflammasomes, activators of IL-1β secretion, particularly in the joints tissues of collagen-induced arthritis (CIA) mice.
Furthermore, the application of TRA also inhibited the enzymes involved in the productions of matrix metalloproteinases (MMPs), like MMP-1 and MMP-3 in HFLS-RA in vitro, degradation of the normal tissues.
Moreover, the injection of TRA also blocked nuclear factor kappa B (NF-κB) activation via modulating inhibitors of kappa B (IκB), IκB kinase (IKK) in the control of cytokines production and cell survival and transforming growth factor-β-activated kinase 1 (TAK1) to prevent the accumulation of ROS, resulting in cell death and inflammation.
Taken altogether, dandelion may be considered a remedy for the treatment of rheumatoid arthritis, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Taraxasterol suppresses inflammation in IL-1β-induced rheumatoid arthritisfibroblast-like synoviocytes and rheumatoid arthritis progression in mice by Chen J1, Wu W2, Zhang M1, Chen C. (PubMed)
There are over 100 different forms of arthritis and related diseases. Rheumatoid arthritis (RA), is the common form of arthritis involved in chronic low-grade inflammation.
Juvenile arthritis is an inflammatory disease affecting the synovium in children aged 16 or younger.
In other words, it is an autoimmune disorder caused by the immune system attacks some of the body's own healthy cells and tissues, in this case, the immune system attacks the joint tissue in the juvenile.
that are associated with the risk of juvenile idiopathic arthritis include HLA-A. HLA-B. HLA-DPB1. HLA-DQA1. HLA-DQB1. HLA-DRB1. IL2RA. IL6, according to the National Institute of Health.
According to the statistic, the most common form of juvenile idiopathic arthritis (JIA), affects over 50,000 children in the United States alone.
Rheumatoid Arthritis (RA) is a type of arthritis associated with inflammation that affects mostly the flexible (synovial) joints and tissues and organs in the body.
The disease affects more women than men and generally occurs after the ages of 40, causing the diminished quality of life of many older adults.
According to the CDC, musculoskeletal disorders (MSDs) affect over 52 million adults in the US alone, including 294,000 children under age 18 with some form of arthritis or rheumatic conditions.
Rheumatoid Arthritis can induce bone loss through elevating bone resorption without increasing bone formation.
A cross-sectional population-based study of 1042 patients with rheumatoid arthritis showed that RA patients had an increased risk of death from various causes.
Dandelion is a herbaceous perennial plant, genus Taraxacum, belongings to the family Asteraceae, native to temperate regions of the world. It has been used in traditional and herbal medicine to treat gout, eczema, acne, gall bladder, kidney, liver and urinary disorders, hypoglycemia, dyspepsia with constipation, edema, blood pressure, and heart weakness, chronic joint, skin diseases, etc.
On finding a natural ingredient for the treatment of chronic inflammatory diseases, scientists examined taraxasterol (TAR), a bioactive active compound pentacyclic triterpenes isolated from Chinese medicine herb Taraxacum officinale effects on rheumatoid arthritis (RA).
In Vitro and Vivo, the application of TRA significantly suppressed the proteins involved in the production of pro-inflammatory cytokines, namely tumor necrosis factor-α (TNF-α), IL-6, and IL-8 by blocking NOD-like receptor protein 3 (NLRP3) inflammasomes, activators of IL-1β secretion, particularly in the joints tissues of collagen-induced arthritis (CIA) mice.
Furthermore, the application of TRA also inhibited the enzymes involved in the productions of matrix metalloproteinases (MMPs), like MMP-1 and MMP-3 in HFLS-RA in vitro, degradation of the normal tissues.
Moreover, the injection of TRA also blocked nuclear factor kappa B (NF-κB) activation via modulating inhibitors of kappa B (IκB), IκB kinase (IKK) in the control of cytokines production and cell survival and transforming growth factor-β-activated kinase 1 (TAK1) to prevent the accumulation of ROS, resulting in cell death and inflammation.
Taken altogether, dandelion may be considered a remedy for the treatment of rheumatoid arthritis, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Taraxasterol suppresses inflammation in IL-1β-induced rheumatoid arthritisfibroblast-like synoviocytes and rheumatoid arthritis progression in mice by Chen J1, Wu W2, Zhang M1, Chen C. (PubMed)
Wednesday, March 11, 2020
Herbal Cramp Bark(Viburnum opulus), the Natural and Potential Gastroduodenoprotective Remedy
The digestive system included the gastrointestinal tract, the liver, pancreas, and gallbladder play a critical role to maintain the body normal function by providing nutrients and fluids to the body and remove waste through the secretary system.
The gastric mucosa is the mucous membrane layer of the stomach that plays a critical role in providing physical protection against ingested particles and preventing the contact between digestive enzymes such as pepsin and the underlying mucosa.
On the other hand, the gastric mucosal barrier protects the stomach against gastric acid that is required for digestion.
Dr, Lawson HH. in the classification of the different histologic types of the normal human duodenal mucosa suggested that there are antral type-duodenal mucosa, the transitional-type duodenal mucosa, and the jejunal-type duodenal mucosa.
The three different types of mucosa vary in their degree of susceptibility to the effect of acid hypersecretion, leading to duodenitis and gastritis and worsens the condition of ulcer.
The function of duodenum mucosa is to increase its surface area that contacts with chyme passing through the intestinal lumen and improves the absorption of nutrients.
Abnormal duodenal mucosa can lead to acute and chronic duodenal ulcers.
Cramp Bark is an ornamental plant, genus Viburnum, belonging to the family Adoxaceae, native to Europe and Asia. It has been used in traditional and herbal medicine as anti-spasmodic, anti-inflammatory, nervine. hypotensive agent and to treat menstrual cramps and pain, afterbirth, postpartum pains, excessive blood loss in periods, bleeding associated with the menopause, etc.
On finding a potential herbal medicine for the protection of the digestive function, researchers examined the gastrointestinal mucosal defense mechanisms of proanthocyanidins (PA), the polymers of flavan-3-ols, isolated from the Viburnum opulus (VOPA, Caprifoliaceae).
According to the tested assays of rats exposed to non-topical ulcerogens (stress) without and with capsaicin (125 mg/kg, sc) denervation, VOPA showed strong effects in the promotion of the gastroduodenal mucosal integrity and pattern, observed by the carbohydrate-binding proteins and nitric oxide (NO) content that protects the intact mucosa.
The levels of antioxidant enzymes produced by the tested rats such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) were also significantly higher in the VOPA group at doses of 25, 50 or 75 mg/kg body weight.
In other words, VOPA inhibited lipid peroxidation by enhancing the production of antioxidant enzymes produced by the host.
Based on the findings, researchers said, "VOPA exerts a potent gastroduodenoprotective activity via an increase in endogenous NO generation, suppression of lipid peroxidation and mobilization of antioxidant activity and changes in glycoconjugate content of the gastroduodenal mucosa of rats".
Taken altogether, cramp bark(Viburnum opulus) may process the gastroduodenoprotective effects, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Influence of Viburnum opulus proanthocyanidins on stress-induced gastrointestinal mucosal damage by Zayachkivska OS1, Gzhegotsky MR, Terletska OI, Lutsyk DA, Yaschenko AM, Dzhura OR. (PubMed)
(2) The duodenal mucosa in health and disease. A clinical and experimental study by Lawson HH. (PubMed)
The gastric mucosa is the mucous membrane layer of the stomach that plays a critical role in providing physical protection against ingested particles and preventing the contact between digestive enzymes such as pepsin and the underlying mucosa.
On the other hand, the gastric mucosal barrier protects the stomach against gastric acid that is required for digestion.
Dr, Lawson HH. in the classification of the different histologic types of the normal human duodenal mucosa suggested that there are antral type-duodenal mucosa, the transitional-type duodenal mucosa, and the jejunal-type duodenal mucosa.
The three different types of mucosa vary in their degree of susceptibility to the effect of acid hypersecretion, leading to duodenitis and gastritis and worsens the condition of ulcer.
The function of duodenum mucosa is to increase its surface area that contacts with chyme passing through the intestinal lumen and improves the absorption of nutrients.
Abnormal duodenal mucosa can lead to acute and chronic duodenal ulcers.
Cramp Bark is an ornamental plant, genus Viburnum, belonging to the family Adoxaceae, native to Europe and Asia. It has been used in traditional and herbal medicine as anti-spasmodic, anti-inflammatory, nervine. hypotensive agent and to treat menstrual cramps and pain, afterbirth, postpartum pains, excessive blood loss in periods, bleeding associated with the menopause, etc.
On finding a potential herbal medicine for the protection of the digestive function, researchers examined the gastrointestinal mucosal defense mechanisms of proanthocyanidins (PA), the polymers of flavan-3-ols, isolated from the Viburnum opulus (VOPA, Caprifoliaceae).
According to the tested assays of rats exposed to non-topical ulcerogens (stress) without and with capsaicin (125 mg/kg, sc) denervation, VOPA showed strong effects in the promotion of the gastroduodenal mucosal integrity and pattern, observed by the carbohydrate-binding proteins and nitric oxide (NO) content that protects the intact mucosa.
The levels of antioxidant enzymes produced by the tested rats such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) were also significantly higher in the VOPA group at doses of 25, 50 or 75 mg/kg body weight.
In other words, VOPA inhibited lipid peroxidation by enhancing the production of antioxidant enzymes produced by the host.
Based on the findings, researchers said, "VOPA exerts a potent gastroduodenoprotective activity via an increase in endogenous NO generation, suppression of lipid peroxidation and mobilization of antioxidant activity and changes in glycoconjugate content of the gastroduodenal mucosa of rats".
Taken altogether, cramp bark(Viburnum opulus) may process the gastroduodenoprotective effects, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Influence of Viburnum opulus proanthocyanidins on stress-induced gastrointestinal mucosal damage by Zayachkivska OS1, Gzhegotsky MR, Terletska OI, Lutsyk DA, Yaschenko AM, Dzhura OR. (PubMed)
(2) The duodenal mucosa in health and disease. A clinical and experimental study by Lawson HH. (PubMed)
Herbal Angelica Processes Neuro-Protective Activity
Neuroprotection is a process to preserve the neuronal structure and/or function against the death or gradual death of neurons, including the use of medicines and herbs.
In other words, neuroprotection protects the neuronal integrity against the reduction in the rate of neuronal loss over time inducing neurological disease, including neurodegenerative disease.
Brain ischemia is a condition caused by insufficient blood flow to the brain to meet metabolic demand, leading to irreversible brain damage in severe cases.
In other words, brain ischemia-induced the death of neurons of the affected tissues.
Brain ischemia can be classified into
* Focal ischemia is a condition caused by damage to a specific region of the brain; and
* Global ischemia is a condition of damage that affects the wide areas of brain tissue, leading to symptoms of impairments in vision, body movement, and speaking.
Dr. Jin-Moo Lee in the study of the issues of how the brain tissue responses to ischemia, said, "The brain is particularly vulnerable to ischemia. Complete interruption of blood flow to the brain for only 5 minutes triggers the death of vulnerable neurons in several brain regions, whereas 20–40 minutes of ischemia is required to kill cardiac myocytes or kidney cells".
And, "...the brain’s intrinsic cell-cell and intracellular signaling mechanisms, normally responsible for information processing, become harmful under ischemic conditions, hastening energy failure and enhancing the final pathways underlying ischemic cell death in all tissues, including free radical production, activation of catabolic enzymes, membrane failure, apoptosis, and inflammation".
Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
On finding a potential compound for the protection of the brain, researchers examined the neuroprotective effects of Xixian Tongshuan Preparation containing Ligusticum chuanxiong, Angelica Sinensis, Carthamus tinctorius, and Panax pseudo-ginseng.
According to chemical analysis, all constituents found in the formula work synergistically to protect the neurons against damage.
Furthermore, the formula inhibited the 5 glutamate receptors, TGFR-1, and VEGFR-2 in the mediation of the production of pro-inflammatory cytokines to induce neuron death and injury.
Moreover, a single component, such as neo-complanatoside and neo-carthamin, in Xixian Tongshuan Preparation could simultaneously act on different targets to exert their neuroprotective effects.
Based on the findings, researchers wrote, "This study explains the multi-target mechanism of anti-cerebral ischemic injury in neuroprotection at the molecular level, and provides a certain direction for the clinical application and experimental research of Xixian Tongshuan Preparation".
Taken altogether, herbal Angelica in combination with other herbal medicines that may be considered a neuroprotective remedy, pending to larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
,
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [Multi-target neuroprotective effect of Xixian Tongshuan Preparation against cerebral ischemia injury].[Article in Chinese] by Gu Y1, Zhao BW1, Chen X1, Luo YZ1, Zhang YL. (PubMed)
(2) Brain tissue responses to ischemia by Jin-Moo Lee, Margaret C. Grabb, Gregory J. Zipfel, and Dennis W. Choi. (PMC)
In other words, neuroprotection protects the neuronal integrity against the reduction in the rate of neuronal loss over time inducing neurological disease, including neurodegenerative disease.
Brain ischemia is a condition caused by insufficient blood flow to the brain to meet metabolic demand, leading to irreversible brain damage in severe cases.
In other words, brain ischemia-induced the death of neurons of the affected tissues.
Brain ischemia can be classified into
* Focal ischemia is a condition caused by damage to a specific region of the brain; and
* Global ischemia is a condition of damage that affects the wide areas of brain tissue, leading to symptoms of impairments in vision, body movement, and speaking.
Dr. Jin-Moo Lee in the study of the issues of how the brain tissue responses to ischemia, said, "The brain is particularly vulnerable to ischemia. Complete interruption of blood flow to the brain for only 5 minutes triggers the death of vulnerable neurons in several brain regions, whereas 20–40 minutes of ischemia is required to kill cardiac myocytes or kidney cells".
And, "...the brain’s intrinsic cell-cell and intracellular signaling mechanisms, normally responsible for information processing, become harmful under ischemic conditions, hastening energy failure and enhancing the final pathways underlying ischemic cell death in all tissues, including free radical production, activation of catabolic enzymes, membrane failure, apoptosis, and inflammation".
Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China.
The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
On finding a potential compound for the protection of the brain, researchers examined the neuroprotective effects of Xixian Tongshuan Preparation containing Ligusticum chuanxiong, Angelica Sinensis, Carthamus tinctorius, and Panax pseudo-ginseng.
According to chemical analysis, all constituents found in the formula work synergistically to protect the neurons against damage.
Furthermore, the formula inhibited the 5 glutamate receptors, TGFR-1, and VEGFR-2 in the mediation of the production of pro-inflammatory cytokines to induce neuron death and injury.
Moreover, a single component, such as neo-complanatoside and neo-carthamin, in Xixian Tongshuan Preparation could simultaneously act on different targets to exert their neuroprotective effects.
Based on the findings, researchers wrote, "This study explains the multi-target mechanism of anti-cerebral ischemic injury in neuroprotection at the molecular level, and provides a certain direction for the clinical application and experimental research of Xixian Tongshuan Preparation".
Taken altogether, herbal Angelica in combination with other herbal medicines that may be considered a neuroprotective remedy, pending to larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
,
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [Multi-target neuroprotective effect of Xixian Tongshuan Preparation against cerebral ischemia injury].[Article in Chinese] by Gu Y1, Zhao BW1, Chen X1, Luo YZ1, Zhang YL. (PubMed)
(2) Brain tissue responses to ischemia by Jin-Moo Lee, Margaret C. Grabb, Gregory J. Zipfel, and Dennis W. Choi. (PMC)
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