Gastrointestinal cancer is a medical and chronic condition caused by the alternation of cell DNA in the gastrointestinal tract including the esophagus, stomach, biliary system, pancreas, small intestine, large intestine, rectum, and anus.
Most cases of gastrointestinal cancer begin in the cell on the surface of the inner lining of the gastrointestinal tissue, before penetrating into the deeper layers.
The most common gastrointestinal cancer is gastric cancer, which is the fourth most commonly occurring cancer in men and the seventh most commonly occurring cancer in women.
According to worldwide statistics, over 1 million new cases were diagnosed in 2018 with the South Korean leading the map, second to Mongolia.
In other words, if you are Asain, you are at an increased risk of gastric cancer.
At the advanced stage, the cancer cell of the affected tissues can travel a distance away to infect the other tissues and organs, leading to secondary metastasis.
Epidemiologically, primary gastrointestinal cancer is more likely to spread to the stomach, esophageal cancer, breast cancer, renal cell carcinoma, and ovarian cancer.
Most common symptoms of gastrointestinal cancer include
* Throw up blood with the color of coffee grounds. if the bleeding cancer is located in the esophagus or stomach
* Black stool if the bleeding cancer is located in the stomach and small intestine.
* Stool red with visible blood if the bleeding cancer is located in the large intestines.
Persistent bleeding to lead anemia due to a large amount of blood loss.
If you have some of the aforementioned symptoms that do heal in a short period of time, you may have gastrointestinal cancer. Please check with your doctor to rule out the possibility.
If the bleeding is slow, it often doesn’t cause the person to throw up blood or have a change in their stool. Over time, though, slow bleeding can lead to a low red blood cell count, and make a person feel tired and weak.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a natural ingredient against gastrointestinal cancer, researchers examined the effects of bromelain and N-acetylcysteine, the two natural agents' anti-cancer effects.
In gastrointestinal cancer models to cisplatin, paclitaxel, 5-fluorouracil, and vincristine, a combination of bromelain and N-acetylcysteine with chemotherapeutic agents could give rise to an improved chemotherapeutic index.
In other words, chemo drugs used combined with bromelain and N-acetylcysteine are more effective in the inhibition of gastrointestinal cancer with lesser toxicity.
Furthermore, combined with bromelain and N-acetylcysteine also reduced the doses of chemo drugs used with the same efficacy.
Based on the findings, researchers said, "This represents a potentially efficacious strategy for the enhancement of microscopic cytoreduction".
Moreover, in the examination of the effects of bromelain (BR) and N-acetylcysteine (NAC) on MUC2 and MUC5AC which have been found to significantly contribute to the biology and pathogenesis of mucin-secreting gastrointestinal tumors, researchers found that in vitro (MKN45, KATOIII and LS174T cell lines) and in vivo (female nude mice bearing intraperitoneal MKN45 and LS174T), a combination of BR and NAC with dual effects on growth and mucin products of mucin-expressing tumor cells.
More precisely, the treatment of the combination of BR and NAC protected the gastric cells against the malignancies with the involvement of mucin pathology.
Taken altogether, bromelain may be considered supplements for the prevention and treatment of gastrointestinal cancer, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Potentiation of chemotherapeutics by bromelain and N-acetylcysteine: sequential and combination therapy of gastrointestinal cancer cells by Amini A1, Masoumi-Moghaddam S1, Ehteda A1, Liauw W2, Morris DL. (PubMed)
(2) Depletion of mucin in mucin-producing human gastrointestinal carcinoma: Results from in vitro and in vivo studies with bromelain and N-acetylcysteine by Amini A1, Masoumi-Moghaddam S1, Ehteda A1, Liauw W2, Morris DL. (PubMed)
Friday, May 15, 2020
Thursday, May 14, 2020
Cramp Bark(Viburnum opulus) in the Prevention and Treatment of Ureteral Stones
The kidneys formed part of the secretary system are two bean-shaped organs located against the back muscles in the upper abdominal area.
The kidneys play a critical role in filtering wastes from the breakdown of active muscle and the food you eat and removing extra water from the blood through urinary secretion.
Furthermore, the kidneys also maintain the fluid in the body by secreting extra water through urinary secretion.
Kidney stones are composed of mineral salts formed in the kidneys. Men account for 80% kidney stones incidence and are at risk of the formings between 30 and 40 years of age. About 75% of kidney stones are calcium stones.
According to statistics, kidney stones affect over 10% of the world population.
The causes of kidney stones are debatable. However, some researchers suggested that dehydration, food restriction, Rotavirus infection, over intake of calcium and supplements,... and high fat intake are associated with increased risk of forming kidney stones.
Ureteral stones are kidney stones that stuck in one or both ureters (the tubes that carry urine from the kidneys to the bladder), leading to the obstruction of the urinary secretion.
Most people with kidney stones are asymptomatic. However, some may experience symptoms of renal colic, an excruciating intermittent pain, usually in the flank (the area between the ribs and hip), that spreads across the abdomen, often to the genital area and inner thigh.
The pain tends to come in waves, gradually increasing to peak intensity, then fading, over about 20 to 60 minutes. The pain may radiate down the abdomen toward the groin or testis or vulva.
Other symptoms include nausea and vomiting, restlessness, sweating, and blood in the urine. A person may have an urge to urinate frequently, particularly as the stone passes down the ureter. Chills, fever, and abdominal distention.
Cramp Bark is an ornamental plant, genus Viburnum, belongings to the family Adoxaceae, native to Europe and Asia. T herbal medicine has been used in traditional and herbal medicine as anti-spasmodic, anti-inflammatory, nervine. hypotensive agent and to treat menstrual cramps and pain, afterbirth, postpartum pains, excessive blood loss in periods, bleeding associated with the menopause, etc.
On finding a potential herbal medicine for the prevention and treatment of kidney stones, researchers examined the efficacy of Gilaburu (Viburnum opulus) extract in the treatment of distal ureteral stones <10 mm.
The study included data of a total of 103 patients retrospectively analyzed. divided into two groups: those given V. opulus 1000 mg peroral 3×2 and diclofenac 50 mg peroral on-demand (n=53) and those given only diclofenac sodium 50 mg peroral on-demand (n=50).
According to the expulsion rate assay, group treated with V. opulus 1000 mg peroral 3×2 and diclofenac 50 mg peroral on-demand showed a rate of stone expulsion that is significantly higher of 82% compared to the diclofenac 50 mg peroral on-demand treatment group of 66%.
Furthermore, elapsed time to stone expulsion was significantly shorter in the V. opulus 1000 mg peroral 3×2 and diclofenac 50 mg peroral on-demand of 9±1.8, compared to another group of 14±2.3 days.
Most importantly, the V. opulus group showed no need for additional treatment (URS and ESWL), and analgesic was less requirement compared to another group.
Based on the findings, researchers said, "V. opulus is an herbal treatment alternative that facilitates the passage of ureteral stones <10 mm. Prospective, randomized studies are needed to support these results".
Taken altogether, cramp bark(Viburnum opulus) may be considered a functional remedy for the treatment of ureteral stones, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The evaluation of the effectiveness of Gilaburu (Viburnum opulus L.) extract in the medical expulsive treatment of distal ureteral stones by Kızılay F1, Ülker V2, Çelik O2, Özdemir T1, Çakmak Ö2, Can E2, Nazlı O. (PubMed)
The kidneys play a critical role in filtering wastes from the breakdown of active muscle and the food you eat and removing extra water from the blood through urinary secretion.
Furthermore, the kidneys also maintain the fluid in the body by secreting extra water through urinary secretion.
Kidney stones are composed of mineral salts formed in the kidneys. Men account for 80% kidney stones incidence and are at risk of the formings between 30 and 40 years of age. About 75% of kidney stones are calcium stones.
According to statistics, kidney stones affect over 10% of the world population.
The causes of kidney stones are debatable. However, some researchers suggested that dehydration, food restriction, Rotavirus infection, over intake of calcium and supplements,... and high fat intake are associated with increased risk of forming kidney stones.
Ureteral stones are kidney stones that stuck in one or both ureters (the tubes that carry urine from the kidneys to the bladder), leading to the obstruction of the urinary secretion.
Most people with kidney stones are asymptomatic. However, some may experience symptoms of renal colic, an excruciating intermittent pain, usually in the flank (the area between the ribs and hip), that spreads across the abdomen, often to the genital area and inner thigh.
The pain tends to come in waves, gradually increasing to peak intensity, then fading, over about 20 to 60 minutes. The pain may radiate down the abdomen toward the groin or testis or vulva.
Other symptoms include nausea and vomiting, restlessness, sweating, and blood in the urine. A person may have an urge to urinate frequently, particularly as the stone passes down the ureter. Chills, fever, and abdominal distention.
Cramp Bark is an ornamental plant, genus Viburnum, belongings to the family Adoxaceae, native to Europe and Asia. T herbal medicine has been used in traditional and herbal medicine as anti-spasmodic, anti-inflammatory, nervine. hypotensive agent and to treat menstrual cramps and pain, afterbirth, postpartum pains, excessive blood loss in periods, bleeding associated with the menopause, etc.
On finding a potential herbal medicine for the prevention and treatment of kidney stones, researchers examined the efficacy of Gilaburu (Viburnum opulus) extract in the treatment of distal ureteral stones <10 mm.
The study included data of a total of 103 patients retrospectively analyzed. divided into two groups: those given V. opulus 1000 mg peroral 3×2 and diclofenac 50 mg peroral on-demand (n=53) and those given only diclofenac sodium 50 mg peroral on-demand (n=50).
According to the expulsion rate assay, group treated with V. opulus 1000 mg peroral 3×2 and diclofenac 50 mg peroral on-demand showed a rate of stone expulsion that is significantly higher of 82% compared to the diclofenac 50 mg peroral on-demand treatment group of 66%.
Furthermore, elapsed time to stone expulsion was significantly shorter in the V. opulus 1000 mg peroral 3×2 and diclofenac 50 mg peroral on-demand of 9±1.8, compared to another group of 14±2.3 days.
Most importantly, the V. opulus group showed no need for additional treatment (URS and ESWL), and analgesic was less requirement compared to another group.
Based on the findings, researchers said, "V. opulus is an herbal treatment alternative that facilitates the passage of ureteral stones <10 mm. Prospective, randomized studies are needed to support these results".
Taken altogether, cramp bark(Viburnum opulus) may be considered a functional remedy for the treatment of ureteral stones, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The evaluation of the effectiveness of Gilaburu (Viburnum opulus L.) extract in the medical expulsive treatment of distal ureteral stones by Kızılay F1, Ülker V2, Çelik O2, Özdemir T1, Çakmak Ö2, Can E2, Nazlı O. (PubMed)
Wednesday, May 13, 2020
Herbal Butterbur, the Potent Anti Somatoform Disorders Functional Remedy
Scientists may have found a natural herbal medicine for the prevention and treatment of Somatoform disorders with no side effects, according to studies.
Somatoform disorders are a group of psychiatric disorders that trigger unexplained physical symptoms.
Researchers do not the exact cause of the disorders. However, genetic preposition and family history are the 2 most common risk factors associated with the onset of the condition.
The most common symptoms include persistent pain or fatigue, emotional distress and problems functioning.
The American Family Physician in the article Somatoform disorders suggested up to 50 percent of primary care patients present with physical symptoms that cannot be explained by a general medical condition. Some of these patients meet the criteria for somatoform disorders.
Dr. Bener A, the lead scientist, in examining the gender effects on somatoform disorders in a sample size of 1689 patients, including 892 men and 797 women suggested
* The prevalence rate of somatoform disorders among the total screened sample was 23.9%.
* Housewives (43.5%) and men in administrative posts (37.9%) reported higher somatic symptoms compared to other professions.
* Prolonged depressive reaction was significantly higher in women compared to men.
* There was a significant gender difference in certain psychiatric diagnostic categories such as depressive episode, recurrent depressive disorder, dysthymia, and brief depressive reaction.
* Backache was the most commonly reported symptom in men, whereas a headache was more common in women.
These results clearly suggested being female is a risk factor of Somatoform disorders and symptoms of Somatoform disorders. Somatoform disorders affect the different aspects of the patient depending on gender.
Women with Somatoform disorders are more likely to experience psychological symptoms compared to males.
Butterbur, found in wet, marshy, damp land, including wetland, riverside, forest, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belonging to the family Asteraceae, native to Northern Hemisphere.
The herbal medicine has been used in herbal medicine used as a pain reliever in the digestive system, including stomach, bile ducts, and duodenum, etc.
The chemical constituents of Butterbur include Petioles, petasitene and pethybrene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petasin, and iso-S-petasin, etc.
With an aim to find a natural formula for the treatment of Somatoform disorder with no side effects, researchers at the University Hospital Zurich examined the effects of mixed herbal drug combination with and without butterbur (Ze 185) on patients with somatoform disorders.
In a total of 182 patients randomized for a 3-arm trial (butterbur root, valerian root, passionflower herb, lemon balm leaf versus valerian root, passionflower herb, lemon balm leaf versus placebo) compared to a fixed herbal drug combination (Ze 185 = 4-combination versus 3-combination without butterbur and placebo) in patients with somatoform disorders in a 2-week treatment in patients with somatization disorder (F45.0) and undifferentiated somatoform disorder (F45.1), researchers discovered the 4-combination was significantly superior to the 3-combination and placebo (4-combination > 3-combination > placebo) in all the primary and secondary parameters (PP-population).
The levels of anxiety and depression, according to the Anxiety (visual analog scale - VAS) and depression (Beck's Depression Inventory - BDI) are also decreased more in 4 combinations compared to others.
According to the Clinical Global Impression (CGI) rating scales, 4 combinations also showed reduced symptom severity and improved treatment response compared to 3 combinations.
The results are further reconfirmed by the ITT population analysis.
Where (ITT) analysis is a treatment in which patients enrolled and randomly allocated to treatment are included in the analysis and are analyzed in the groups to which they were randomized.
All tested subjects expressed no serious adverse effects during the course of experiments.
These results suggested that herbal preparation (Ze185) may be an efficacious and safe short-term treatment in patients with somatoform disorders.
Taken altogether, herbal Butterbur used alone or combined with other herbal medicine may be considered a functional herbal for prevention and combined with the primary medicine for the treatment of Somatoform disorder with no serious side effects,
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Fixed herbal drug combination with and without butterbur (Ze 185) for the treatment of patients with somatoform disorders: randomized, placebo-controlled pharmaco-clinical trial by Melzer J, Schrader E, Brattström A, Schellenberg R, Saller R.(PubMed)
Somatoform disorders are a group of psychiatric disorders that trigger unexplained physical symptoms.
Researchers do not the exact cause of the disorders. However, genetic preposition and family history are the 2 most common risk factors associated with the onset of the condition.
The most common symptoms include persistent pain or fatigue, emotional distress and problems functioning.
The American Family Physician in the article Somatoform disorders suggested up to 50 percent of primary care patients present with physical symptoms that cannot be explained by a general medical condition. Some of these patients meet the criteria for somatoform disorders.
Dr. Bener A, the lead scientist, in examining the gender effects on somatoform disorders in a sample size of 1689 patients, including 892 men and 797 women suggested
* The prevalence rate of somatoform disorders among the total screened sample was 23.9%.
* Housewives (43.5%) and men in administrative posts (37.9%) reported higher somatic symptoms compared to other professions.
* Prolonged depressive reaction was significantly higher in women compared to men.
* There was a significant gender difference in certain psychiatric diagnostic categories such as depressive episode, recurrent depressive disorder, dysthymia, and brief depressive reaction.
* Backache was the most commonly reported symptom in men, whereas a headache was more common in women.
These results clearly suggested being female is a risk factor of Somatoform disorders and symptoms of Somatoform disorders. Somatoform disorders affect the different aspects of the patient depending on gender.
Women with Somatoform disorders are more likely to experience psychological symptoms compared to males.
Butterbur, found in wet, marshy, damp land, including wetland, riverside, forest, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belonging to the family Asteraceae, native to Northern Hemisphere.
The herbal medicine has been used in herbal medicine used as a pain reliever in the digestive system, including stomach, bile ducts, and duodenum, etc.
The chemical constituents of Butterbur include Petioles, petasitene and pethybrene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petasin, and iso-S-petasin, etc.
With an aim to find a natural formula for the treatment of Somatoform disorder with no side effects, researchers at the University Hospital Zurich examined the effects of mixed herbal drug combination with and without butterbur (Ze 185) on patients with somatoform disorders.
In a total of 182 patients randomized for a 3-arm trial (butterbur root, valerian root, passionflower herb, lemon balm leaf versus valerian root, passionflower herb, lemon balm leaf versus placebo) compared to a fixed herbal drug combination (Ze 185 = 4-combination versus 3-combination without butterbur and placebo) in patients with somatoform disorders in a 2-week treatment in patients with somatization disorder (F45.0) and undifferentiated somatoform disorder (F45.1), researchers discovered the 4-combination was significantly superior to the 3-combination and placebo (4-combination > 3-combination > placebo) in all the primary and secondary parameters (PP-population).
The levels of anxiety and depression, according to the Anxiety (visual analog scale - VAS) and depression (Beck's Depression Inventory - BDI) are also decreased more in 4 combinations compared to others.
According to the Clinical Global Impression (CGI) rating scales, 4 combinations also showed reduced symptom severity and improved treatment response compared to 3 combinations.
The results are further reconfirmed by the ITT population analysis.
Where (ITT) analysis is a treatment in which patients enrolled and randomly allocated to treatment are included in the analysis and are analyzed in the groups to which they were randomized.
All tested subjects expressed no serious adverse effects during the course of experiments.
These results suggested that herbal preparation (Ze185) may be an efficacious and safe short-term treatment in patients with somatoform disorders.
Taken altogether, herbal Butterbur used alone or combined with other herbal medicine may be considered a functional herbal for prevention and combined with the primary medicine for the treatment of Somatoform disorder with no serious side effects,
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Fixed herbal drug combination with and without butterbur (Ze 185) for the treatment of patients with somatoform disorders: randomized, placebo-controlled pharmaco-clinical trial by Melzer J, Schrader E, Brattström A, Schellenberg R, Saller R.(PubMed)
Tuesday, May 12, 2020
Herbal Butterbur, the Potent Neuro-protective Bioactive Herbal Medicine
Herbal Butterbur may have a profound and strong effect on protecting the neuron integrity and validity against the onset of neuro diseases, some scientists suggested.
Neuroprotective effects are the activity that protects neurons of the brain and spinal cord.
A neurologic deficit is a condition of the brain, spinal cord, leading to weaker muscles, nerves, or part of the body.
The causes of neurological deficit include genetic disorders, congenital abnormalities or disorders, infections, lifestyle or environmental health problems associated with malnutrition, and brain injury, spinal cord injury, or nerve injury.
People of neurologic deficit may experience certain medical conditions and symptoms including partial or complete paralysis, and loss of sensation, seizures, difficulty reading, and writing and walking, and decreased alertness.
However, some researchers suggested the most serious symptoms are poor cognitive ability, depending on the parts of the brain or spinal cord which have been affected.
According to the statistic provided by the US government, more than 16 million people in the United States are living with cognitive impairment and disease with a tendency to increase at an alarming rate, particularly in the age group of 50 and over.
People with cognitive impairment, according to the report are more than three times as many hospitals stay as individuals who are hospitalized for some other condition, causing a substantial burden to the US health care system.
Out of all neurodegenerative diseases, Alzheimer’s disease and related dementias alone are estimated to be the third most expensive disease to treat in the United States.
The Alzheimer’s Disease Facts and Figures 20106, wrote, “ The average Medicaid payment for a person aged 65 or older with Alzheimer’s or other dementias is nine times higher than that for other beneficiaries in the same age group.”
Butterbur, found in wet, marshy, damp land, including wetland, riverside, forest, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belonging to the family Asteraceae, native to Northern Hemisphere.
The herbal medicine has been used in herbal medicine used as a pain reliever in the digestive system, including stomach, bile ducts, and duodenum, etc.
The chemical constituents of Butterbur include Petioles, petasitene and pethybrene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petasin and iso-S-petasin, etc.
The Second Military Medical University on finding a natural ingredient or whole food for the treatment of neurologic deficit examine the effect of the total bakkenolides, a bioactive compound isolated from the herbal Butterbur, in vitro cerebral ischemia model and oxygen-glucose deprivation of cultured nerve cells.
Oral administration of total bakkenolides showed a significant immediate effect after reperfusion at doses of 5, 10, and 20 mg/kg markedly reduced brain infarct volume and neurological deficits.
The chemical compound also was found to attenuate cell death and apoptosis in primary cultured neurons subject to 1-h hypoxia followed by 24-h reoxygenation.
The compound also protects the neurons by inhibiting the protein involved production of inflammatory cytokines through blocking the activation of the classical activation pathway due to the injury.
Further differentiation of the experiment, researchers discovered that total bakkenolides inhibit the activation of pathways associated with neuron apoptosis.
Dr. the lead scientists after taking into account of co and confounders said, "our results provide a strong pharmacological basis for further understanding the potential therapeutic role of total bakkenolides in cerebral ischemic disease and shed new light on its neuroprotective mechanism".
Moreover, in the examine the neurologic deficit effects of 4 novel bakkenolides - bakkenolide-Ia ( 1), bakkenolide-IIa ( 2), bakkenolide-IIIa ( 3) and bakkenolide-IVa ( 4) isolated from the extract of the rhizome of Petasites tricholobus, researchers showed the compounds 1 - 4 exert a significantly neuroprotective activity in primary cultured neurons exposed to oxygen-glucose deprivation and oxidative insults by enhancing the antioxidant activity.
According to the VITRO assay, all these compounds exhibited significant neuroprotective and antioxidant activities.
The findings strongly suggested total bakkenolides and its derivative demonstrate neurologic deficits protective effects through blocking the mechanisms involved neuron cells apoptosis through their antioxidant property.
Taken altogether, herbal Butterbur processed bioactive compounds such as bakkenolides may be considered a functional herb for the prevention and combined with primary medicine for the treatment of neurologic deficits.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Total Bakkenolides Protects Neurons against Cerebral Ischemic Injury through Inhibition of Nuclear Factor-Κb Activation by Jiang Q, Xia Yy EY, Jm HE, Guo Ml EY, Rp LI. (PubMed)
(2) Bakkenolides from Petasites tricholobus and their neuroprotective effects related to antioxidant activities by Wang YL, Li RP, Guo ML, Zhang G, Zhang N, Ma YL.(PubMed)
(3) Protection by petaslignolide A, a major neuroprotective compound in the butanol extract of Petasites japonicus leaves, against oxidative damage in the brains of mice challenged with kainic acid by Cui HS, Kim MR, Sok DE. (PubMed)
Neuroprotective effects are the activity that protects neurons of the brain and spinal cord.
A neurologic deficit is a condition of the brain, spinal cord, leading to weaker muscles, nerves, or part of the body.
The causes of neurological deficit include genetic disorders, congenital abnormalities or disorders, infections, lifestyle or environmental health problems associated with malnutrition, and brain injury, spinal cord injury, or nerve injury.
People of neurologic deficit may experience certain medical conditions and symptoms including partial or complete paralysis, and loss of sensation, seizures, difficulty reading, and writing and walking, and decreased alertness.
However, some researchers suggested the most serious symptoms are poor cognitive ability, depending on the parts of the brain or spinal cord which have been affected.
According to the statistic provided by the US government, more than 16 million people in the United States are living with cognitive impairment and disease with a tendency to increase at an alarming rate, particularly in the age group of 50 and over.
People with cognitive impairment, according to the report are more than three times as many hospitals stay as individuals who are hospitalized for some other condition, causing a substantial burden to the US health care system.
Out of all neurodegenerative diseases, Alzheimer’s disease and related dementias alone are estimated to be the third most expensive disease to treat in the United States.
The Alzheimer’s Disease Facts and Figures 20106, wrote, “ The average Medicaid payment for a person aged 65 or older with Alzheimer’s or other dementias is nine times higher than that for other beneficiaries in the same age group.”
Butterbur, found in wet, marshy, damp land, including wetland, riverside, forest, etc., is a creeping underground plant, genus Petasites of 15 -20 species, belonging to the family Asteraceae, native to Northern Hemisphere.
The herbal medicine has been used in herbal medicine used as a pain reliever in the digestive system, including stomach, bile ducts, and duodenum, etc.
The chemical constituents of Butterbur include Petioles, petasitene and pethybrene, quercetin 3-O-beta-D-glucoside, quercetin 3-O-beta-D-6''-O-acetylglucoside, and rutin, caffeic acid, alkaloids, S-petasin and iso-S-petasin, etc.
The Second Military Medical University on finding a natural ingredient or whole food for the treatment of neurologic deficit examine the effect of the total bakkenolides, a bioactive compound isolated from the herbal Butterbur, in vitro cerebral ischemia model and oxygen-glucose deprivation of cultured nerve cells.
Oral administration of total bakkenolides showed a significant immediate effect after reperfusion at doses of 5, 10, and 20 mg/kg markedly reduced brain infarct volume and neurological deficits.
The chemical compound also was found to attenuate cell death and apoptosis in primary cultured neurons subject to 1-h hypoxia followed by 24-h reoxygenation.
The compound also protects the neurons by inhibiting the protein involved production of inflammatory cytokines through blocking the activation of the classical activation pathway due to the injury.
Further differentiation of the experiment, researchers discovered that total bakkenolides inhibit the activation of pathways associated with neuron apoptosis.
Dr. the lead scientists after taking into account of co and confounders said, "our results provide a strong pharmacological basis for further understanding the potential therapeutic role of total bakkenolides in cerebral ischemic disease and shed new light on its neuroprotective mechanism".
Moreover, in the examine the neurologic deficit effects of 4 novel bakkenolides - bakkenolide-Ia ( 1), bakkenolide-IIa ( 2), bakkenolide-IIIa ( 3) and bakkenolide-IVa ( 4) isolated from the extract of the rhizome of Petasites tricholobus, researchers showed the compounds 1 - 4 exert a significantly neuroprotective activity in primary cultured neurons exposed to oxygen-glucose deprivation and oxidative insults by enhancing the antioxidant activity.
According to the VITRO assay, all these compounds exhibited significant neuroprotective and antioxidant activities.
The findings strongly suggested total bakkenolides and its derivative demonstrate neurologic deficits protective effects through blocking the mechanisms involved neuron cells apoptosis through their antioxidant property.
Taken altogether, herbal Butterbur processed bioactive compounds such as bakkenolides may be considered a functional herb for the prevention and combined with primary medicine for the treatment of neurologic deficits.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Total Bakkenolides Protects Neurons against Cerebral Ischemic Injury through Inhibition of Nuclear Factor-Κb Activation by Jiang Q, Xia Yy EY, Jm HE, Guo Ml EY, Rp LI. (PubMed)
(2) Bakkenolides from Petasites tricholobus and their neuroprotective effects related to antioxidant activities by Wang YL, Li RP, Guo ML, Zhang G, Zhang N, Ma YL.(PubMed)
(3) Protection by petaslignolide A, a major neuroprotective compound in the butanol extract of Petasites japonicus leaves, against oxidative damage in the brains of mice challenged with kainic acid by Cui HS, Kim MR, Sok DE. (PubMed)
Monday, May 11, 2020
Herbal Chaste Tree Berry, the Best MALE Osteoprotective Natural Medicine
Chaste tree berry is a species of Vitex agnus-castus, genus Vitex, belonging to the family Lamiaceae, native to the Mediterranean region, used in herbal medicine for thousands of years as anaphrodisiac herb and considered as Queen herb in treating menstrual problems and discomforts.
Osteoporosis is a condition of thinning of bone and bone tissues as a result of the loss of bone density over a long period of time.
In a total of 60, 3-month-old male rats orchidectomized and divided into five groups with each group either received soy-free food (C), estradiol (E), testosterone (T) or Vitex agnus castus in different concentrations (AC high/AC low) for 12 weeks, rats treated with Vitex agnus castus at highest dose displayed a recover of 88.4% of trabecular bone area, 80.7% of trabecular number and 66.9% of the number of trabecular nodes compared with other administrations.
The study also found out that Vitex agnus castus is more protective in treating osteoporosis in the male population, compared female counterparts.
Dr. Sehmisch S, the lead author said, " Vitex agnus castus demonstrated osteoprotective effects in males. It preserves the cortical as well as the trabecular bone and might be a safe alternative for HRT".
Furthermore, In the study to compare a group of animals (n = 8) treated subcutaneously (s.c.) with 60 mg/kg of Vac essential oil once a day for 3 weeks and control animals (n = 8) received sterile olive oil s.c. by the same schedule, Vitex agnus-castus L. (Vac) essential oil-treated group also exerted a significant bone metabolism in 16-month-old male Wistar rats.
The osteoporosis protection can be observed through the lower Serum osteocalcin (OC) and calcium (Ca2+) in Vitex agnus-castus L. (Vac) essential oil and decreased bone turnover treated group in compared control in middle-aged male rats.
Taking together, Chaste tree berry showed strong support in the reduced early onset of osteoporosis of male gander through improved bone metabolism and calcium status, but the further large size and multi centers studies are necessary to validate this potency.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Vitex agnus castus as prophylaxis for osteopenia after orchidectomy in rats compared with estradiol and testosterone supplementation by Sehmisch S1, Boeckhoff J, Wille J, Seidlova-Wuttke D, Rack T, Tezval M, Wuttke W, Stuermer KM, Stuermer EK.(PubMed)
(2) Vitex agnus-castus essential oil affects thyroid C cells and bone metabolism in middle-aged male rats (Researchgate)
Sunday, May 10, 2020
Herbal Comfrey (Symphytum officinale L.), the Remedy for the Treatment of Painful osteoarthritis
Osteoarthritis (OA) one of the most common forms of arthritis that affects over 25 25 million people in the United State, is a chronic inflammatory disease of the joints due to wear and tear over time.
The characteristics of osteoarthritis are aching pain, stiffness, or difficulty of moving the joint or joints. The pain usually gets worse in a change of weather, at night and in the advanced diseases, the pain can occur even at rest.
Conventionally, treatment of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, nonpharmacological, and surgical treatments.
The most common risk factors associated with the onset of OA include genetic preposition, being overweight or obese, previous joint injury and repetitive movements, or injuries to joints (such as a fracture, surgery, or ligament tears).
the most common diseases associated with OA are
* Hypertension
According to the University Health Network Research Institute, the economic burden incurred by RA significantly exceeds that related to OA and HBP(76)(77).
* Cardiovascular disease
According to Erasmus University Medical Centre, there are associations of atherosclerosis with osteoarthritis of the knee and hand joints in women(72)(73)(78).
* Peripheral vascular disease
According to Himchan Hospital, patients with due to osteoarthritis are associated to risk of asymptomatic peripheral vascular disease(80). The average vessel wall thickness of the popliteal artery was 1.09 mm in patients with generalized OA, and 0.96 mm in the matched normal reference population(79).
* Congestive heart failure
Hypertension, diabetes, and older age have shown to increased risk of Congestive heart failure modestly(81). Etoricoxib, anti-inflammatory painkillers showed statistically significant inhibition at 90 mg in patients with osteoarthritis and rheumatoid arthritis(82).
* Renal function impairment
According to the Southampton University Hospitals NHS Trust, pain pharmacotherapies such as osteoarthritis (OA) or mixed OA and rheumatoid arthritis may increase the risk of adverse events in patients with concurrent cardiovascular (CV) or renal disease(83). Median excretion of pyridinoline and deoxypyridinoline in the OA patients as a whole was raised above values found in a healthy control population(84).
* Diabetes
Several epidemiological and experimental data support the hypothesis that diabetes could be an independent risk factor for osteoarthritis (OA)(76)(85).
Comfrey is a perennial plant in the genus of Symphytum, belonging to the family Boraginaceae, native to Europe. It has been used in herbal and traditional medicine to ease excessive bleeding or on open wounds, relieve pain and swollen, treat circulation issues, reduce cholesterol, etc.
On finding a potential compound for the treatment of osteoarthritis, researchers investigated the effect of Kytta-Salbe f (3 x 2 g), a topical including comfrey over a 3 week period with patients suffering from painful osteoarthritis of the knee.
The randomized, double-blind, bi-center, placebo-controlled clinical trial including 220 patients was conducted by the Merck Selbstmedikation GmbH.
In the course of the trial, the visual analog scale (VAS) total score (primary target value) in the verum group dropped by 51.6 mm (54.7%) and in the placebo group by 10.1 mm (10.7%).
The average difference between the groups of 41.5 mm (95% confidence interval=34.8 to 48.2 mm) or 44.0% is significant (p<0.001).
The WOMAC (Western Ontario and McMaster Universities) total score (secondary target value) also improved similarly to the VAS total score.
At the end of the trial, a reduction by 60.4 mm (58.0%) was recorded for the verum group and a reduction of 14.7 mm (14.1%) for the placebo group.
The average group difference of 45.7 mm (95% confidence interval=37.1 to 54.3 mm) or 43.9% is significant (p<0.001).
The difference between the treatment groups increased systematically and significantly, in parallel with the duration of the treatment.
Based on the results, researchers said, "the superiority of the treatment with Kytta-Salbe f over that with the placebo is proven, even by means of the multi-factorial multivariate analysis for repetitive measurements. In respect of the explorative secondary target values SF-36 (quality of life), angle measurement (mobility of the knee), CGI (clinical global impression) and global assessment of efficacy by the physician and the patient, a significant superiority (p<0.001 each) of the verum group over the placebo group was also proven".
Taken altogether, Comfrey combined with other herbal medicine may be considered for the treatment of a remedy painful osteoarthritis, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Efficacy of a comfrey root (Symphyti offic. radix) extract ointment in the treatment of patients with painful osteoarthritis of the knee: results of a double-blind, randomised, bicenter, placebo-controlled trial by Grube B1, Grünwald J, Krug L, Staiger C. (PubMed)
(2) The Research and Studies of Musculo-Skeletal disorders(MSDs) - Osteoarthritis: The Diseases associated with osteoarthritis by Kyle J. Norton
The characteristics of osteoarthritis are aching pain, stiffness, or difficulty of moving the joint or joints. The pain usually gets worse in a change of weather, at night and in the advanced diseases, the pain can occur even at rest.
Conventionally, treatment of osteoarthritis (OA) focuses on pain relief and improved physical function through pharmacological, nonpharmacological, and surgical treatments.
The most common risk factors associated with the onset of OA include genetic preposition, being overweight or obese, previous joint injury and repetitive movements, or injuries to joints (such as a fracture, surgery, or ligament tears).
the most common diseases associated with OA are
* Hypertension
According to the University Health Network Research Institute, the economic burden incurred by RA significantly exceeds that related to OA and HBP(76)(77).
* Cardiovascular disease
According to Erasmus University Medical Centre, there are associations of atherosclerosis with osteoarthritis of the knee and hand joints in women(72)(73)(78).
* Peripheral vascular disease
According to Himchan Hospital, patients with due to osteoarthritis are associated to risk of asymptomatic peripheral vascular disease(80). The average vessel wall thickness of the popliteal artery was 1.09 mm in patients with generalized OA, and 0.96 mm in the matched normal reference population(79).
* Congestive heart failure
Hypertension, diabetes, and older age have shown to increased risk of Congestive heart failure modestly(81). Etoricoxib, anti-inflammatory painkillers showed statistically significant inhibition at 90 mg in patients with osteoarthritis and rheumatoid arthritis(82).
* Renal function impairment
According to the Southampton University Hospitals NHS Trust, pain pharmacotherapies such as osteoarthritis (OA) or mixed OA and rheumatoid arthritis may increase the risk of adverse events in patients with concurrent cardiovascular (CV) or renal disease(83). Median excretion of pyridinoline and deoxypyridinoline in the OA patients as a whole was raised above values found in a healthy control population(84).
* Diabetes
Several epidemiological and experimental data support the hypothesis that diabetes could be an independent risk factor for osteoarthritis (OA)(76)(85).
Comfrey is a perennial plant in the genus of Symphytum, belonging to the family Boraginaceae, native to Europe. It has been used in herbal and traditional medicine to ease excessive bleeding or on open wounds, relieve pain and swollen, treat circulation issues, reduce cholesterol, etc.
On finding a potential compound for the treatment of osteoarthritis, researchers investigated the effect of Kytta-Salbe f (3 x 2 g), a topical including comfrey over a 3 week period with patients suffering from painful osteoarthritis of the knee.
The randomized, double-blind, bi-center, placebo-controlled clinical trial including 220 patients was conducted by the Merck Selbstmedikation GmbH.
In the course of the trial, the visual analog scale (VAS) total score (primary target value) in the verum group dropped by 51.6 mm (54.7%) and in the placebo group by 10.1 mm (10.7%).
The average difference between the groups of 41.5 mm (95% confidence interval=34.8 to 48.2 mm) or 44.0% is significant (p<0.001).
The WOMAC (Western Ontario and McMaster Universities) total score (secondary target value) also improved similarly to the VAS total score.
At the end of the trial, a reduction by 60.4 mm (58.0%) was recorded for the verum group and a reduction of 14.7 mm (14.1%) for the placebo group.
The average group difference of 45.7 mm (95% confidence interval=37.1 to 54.3 mm) or 43.9% is significant (p<0.001).
The difference between the treatment groups increased systematically and significantly, in parallel with the duration of the treatment.
Based on the results, researchers said, "the superiority of the treatment with Kytta-Salbe f over that with the placebo is proven, even by means of the multi-factorial multivariate analysis for repetitive measurements. In respect of the explorative secondary target values SF-36 (quality of life), angle measurement (mobility of the knee), CGI (clinical global impression) and global assessment of efficacy by the physician and the patient, a significant superiority (p<0.001 each) of the verum group over the placebo group was also proven".
Taken altogether, Comfrey combined with other herbal medicine may be considered for the treatment of a remedy painful osteoarthritis, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Efficacy of a comfrey root (Symphyti offic. radix) extract ointment in the treatment of patients with painful osteoarthritis of the knee: results of a double-blind, randomised, bicenter, placebo-controlled trial by Grube B1, Grünwald J, Krug L, Staiger C. (PubMed)
(2) The Research and Studies of Musculo-Skeletal disorders(MSDs) - Osteoarthritis: The Diseases associated with osteoarthritis by Kyle J. Norton
Saturday, May 9, 2020
Herbal Angelica in the Prevention and Treatment of Ulcerative Colitis
Colitis is a condition of inflammation of the large intestine, including the colon, caecum, and rectum.
There is a number of causes of the disease, including infection, inflammatory bowel disease, and allergic reactions.
Ulcerative colitis is a condition of inflammatory bowel disease (IBD) inducing long-lasting inflammation and ulcers in the digestive tract.
More precisely, ulcerative colitis is a chronic disease that causes inflammation and ulcers within the inner lining of your large intestine. Most cases of ulcerative colitis start in the rectum and spread to the colon.
Symptoms of UC is totally depending on the severity of the disease, including diarrhea, often with blood or pus, persistently abdominal pain, rectal pain, and bleeding, particularly the inability to defecate despite the urgency.
Some patients with UC may also have symptoms of weight loss, fatigue fever.
According to the statistics in the US, out of 1.6 million Americans with inflammatory bowel disease, 907,000 of them have ulcerative colitis.
Depending on the location, most common types of UC can be classified into * Acute severe ulcerative colitis is a medical emergency that requires immediate hospitalization. The condition affects the entire colon with severe acute symptoms of pain, profuse diarrhea, bleeding, fever.
* Ulcerative proctitis is an Inflammation of the anus (rectum), inducing symptoms of rectal bleeding.
* Proctosigmoiditis is an Inflammation involved in the rectum and sigmoid colon (lower end of the colon).
The exact causes of UC are not cleared. Some researchers suggested there are a complex interaction of genetics, immune response, and environmental triggers that cause the onset of the disease.
The most common risk factors of UC include genetic preposition, autoimmune diseases, smoking, use of certain medications such as antibiotics, and smoking.
Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China. The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
On finding a potential compound for the prevention of colitis, researchers examined the decursin and decursinol angelate-rich Angelica gigas Nakai (AGNE) on dextran sulfate sodium (DSS)-induced murine ulcerative colitis (UC) in a mouse model.
In mice with DSS-induced UC, treatment with the AGNE at 10, 20, and 40 mg/kg exerted strong colonic protection and activity by alleviating decreased disease activity index scores, and reduced colon shortening and weight loss.
Levels of pro-inflammatory cytokines were also decreased in serum and colon tissue with the administration of AGNE.
Furthermore, AGNE also improved the colon movement by increasing the production of PGE2 in colon tissue and suppressed the increased expression of COX-2 and HIF-1α in the increased intestinal mucosa of UC mouse.
Finally, the histological damage of the colon was also alleviated by AGNE treatment.
Collectively, researchers said, "The findings of this study verified that AGNE significantly improves clinical symptoms and reduces the activity of various inflammatory mediators. These results indicate the AGNE has the therapeutic potential in mice with DSS-induced UC".
Taken altogether, herbal Angelica may be considered a remedy dor the treatment of UC, pending to larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effect of decursin and decursinol angelate-rich Angelica gigas Nakai extract on dextran sulfate sodium-induced murine ulcerative colitis by Oh SR1, Ok S1, Jung TS1, Jeon SO1, Park JM1, Jung JW2, Ryu DS. (PubMed)
There is a number of causes of the disease, including infection, inflammatory bowel disease, and allergic reactions.
Ulcerative colitis is a condition of inflammatory bowel disease (IBD) inducing long-lasting inflammation and ulcers in the digestive tract.
More precisely, ulcerative colitis is a chronic disease that causes inflammation and ulcers within the inner lining of your large intestine. Most cases of ulcerative colitis start in the rectum and spread to the colon.
Symptoms of UC is totally depending on the severity of the disease, including diarrhea, often with blood or pus, persistently abdominal pain, rectal pain, and bleeding, particularly the inability to defecate despite the urgency.
Some patients with UC may also have symptoms of weight loss, fatigue fever.
According to the statistics in the US, out of 1.6 million Americans with inflammatory bowel disease, 907,000 of them have ulcerative colitis.
Depending on the location, most common types of UC can be classified into * Acute severe ulcerative colitis is a medical emergency that requires immediate hospitalization. The condition affects the entire colon with severe acute symptoms of pain, profuse diarrhea, bleeding, fever.
* Ulcerative proctitis is an Inflammation of the anus (rectum), inducing symptoms of rectal bleeding.
* Proctosigmoiditis is an Inflammation involved in the rectum and sigmoid colon (lower end of the colon).
The exact causes of UC are not cleared. Some researchers suggested there are a complex interaction of genetics, immune response, and environmental triggers that cause the onset of the disease.
The most common risk factors of UC include genetic preposition, autoimmune diseases, smoking, use of certain medications such as antibiotics, and smoking.
Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China. The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
On finding a potential compound for the prevention of colitis, researchers examined the decursin and decursinol angelate-rich Angelica gigas Nakai (AGNE) on dextran sulfate sodium (DSS)-induced murine ulcerative colitis (UC) in a mouse model.
In mice with DSS-induced UC, treatment with the AGNE at 10, 20, and 40 mg/kg exerted strong colonic protection and activity by alleviating decreased disease activity index scores, and reduced colon shortening and weight loss.
Levels of pro-inflammatory cytokines were also decreased in serum and colon tissue with the administration of AGNE.
Furthermore, AGNE also improved the colon movement by increasing the production of PGE2 in colon tissue and suppressed the increased expression of COX-2 and HIF-1α in the increased intestinal mucosa of UC mouse.
Finally, the histological damage of the colon was also alleviated by AGNE treatment.
Collectively, researchers said, "The findings of this study verified that AGNE significantly improves clinical symptoms and reduces the activity of various inflammatory mediators. These results indicate the AGNE has the therapeutic potential in mice with DSS-induced UC".
Taken altogether, herbal Angelica may be considered a remedy dor the treatment of UC, pending to larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effect of decursin and decursinol angelate-rich Angelica gigas Nakai extract on dextran sulfate sodium-induced murine ulcerative colitis by Oh SR1, Ok S1, Jung TS1, Jeon SO1, Park JM1, Jung JW2, Ryu DS. (PubMed)
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