Colitis is a condition of inflammation of the large intestine, including the colon, caecum, and rectum.
There is a number of causes of the disease, including infection, inflammatory bowel disease, and allergic reactions.
Ulcerative colitis is a condition of inflammatory bowel disease (IBD) inducing long-lasting inflammation and ulcers in the digestive tract.
More precisely, ulcerative colitis is a chronic disease that causes inflammation and ulcers within the inner lining of your large intestine. Most cases of ulcerative colitis start in the rectum and spread to the colon.
Symptoms of UC is totally depending on the severity of the disease, including diarrhea, often with blood or pus, persistently abdominal pain, rectal pain, and bleeding, particularly the inability to defecate despite the urgency.
Some patients with UC may also have symptoms of weight loss, fatigue fever.
According to the statistics in the US, out of 1.6 million Americans with inflammatory bowel disease, 907,000 of them have ulcerative colitis.
Depending on the location, most common types of UC can be classified into * Acute severe ulcerative colitis is a medical emergency that requires immediate hospitalization. The condition affects the entire colon with severe acute symptoms of pain, profuse diarrhea, bleeding, fever.
* Ulcerative proctitis is an Inflammation of the anus (rectum), inducing symptoms of rectal bleeding.
* Proctosigmoiditis is an Inflammation involved in the rectum and sigmoid colon (lower end of the colon).
The exact causes of UC are not cleared. Some researchers suggested there are a complex interaction of genetics, immune response, and environmental triggers that cause the onset of the disease.
The most common risk factors of UC include genetic preposition, autoimmune diseases, smoking, use of certain medications such as antibiotics, and smoking.
Angelica or Dang Qui is a herb of Genus Angelica from the family Apiaceae, indigenous to China. The herb has been used as a Queen herb in traditional Chinese medicine antispasmodic and vasodilatory agent, and to balance the hormones in women for a normal menstrual cycle and menstruation and strengthen heart, spleen, kidneys, and liver for both men and women, etc. In other words, it is used to treat gynecological ailments, fatigue, mild anemia, and high blood pressure. It has analgesic, anti-inflammatory, etc.
On finding a potential compound for the prevention of colitis, researchers examined the decursin and decursinol angelate-rich Angelica gigas Nakai (AGNE) on dextran sulfate sodium (DSS)-induced murine ulcerative colitis (UC) in a mouse model.
In mice with DSS-induced UC, treatment with the AGNE at 10, 20, and 40 mg/kg exerted strong colonic protection and activity by alleviating decreased disease activity index scores, and reduced colon shortening and weight loss.
Levels of pro-inflammatory cytokines were also decreased in serum and colon tissue with the administration of AGNE.
Furthermore, AGNE also improved the colon movement by increasing the production of PGE2 in colon tissue and suppressed the increased expression of COX-2 and HIF-1α in the increased intestinal mucosa of UC mouse.
Finally, the histological damage of the colon was also alleviated by AGNE treatment.
Collectively, researchers said, "The findings of this study verified that AGNE significantly improves clinical symptoms and reduces the activity of various inflammatory mediators. These results indicate the AGNE has the therapeutic potential in mice with DSS-induced UC".
Taken altogether, herbal Angelica may be considered a remedy dor the treatment of UC, pending to larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effect of decursin and decursinol angelate-rich Angelica gigas Nakai extract on dextran sulfate sodium-induced murine ulcerative colitis by Oh SR1, Ok S1, Jung TS1, Jeon SO1, Park JM1, Jung JW2, Ryu DS. (PubMed)
No comments:
Post a Comment