The smoothie of Green tea, Huang Lian, Turmeric and Honey for Polycystic Ovarian Syndrome(PCOs)

Kyle J. Norton(Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for people with  Polycystic Ovarian Syndrome(PCOs) and high risk of the sundrome

Yield: 2 servings (about 8 ounce each)
4 grams Huang lian(You can easily buy them in Chinese herbal store, and boil them in 3 cups of water at high heat then turn the heat to minimum until obtaining 1 cup of water)
2 tsp of honey
200 mg of standardized powder (curcumin)
1 cups green tea drink 1 cup green tea drink (Make from 4 grams(2 tea bags) of green tea, and a cup of hot water lipped for 5 minutes, and set aside for cooling to room temperature)


1. Place all ingredients,  in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The findings of a natural ingredient to induce fertility and for treatment of polycystic ovarian syndrome from scientific communities have not been abating. But unfortunately, many ingredients showed extremely prominent in animal studies do not produce the same effects in human trials.

Green tea, only of most common beverage originated from South East Asian now has been drunk  and loved all over the world due to its commercial profits and health benefits. Recent study suggested that green tea and may consist a healing effects on polycystic ovarian syndrome by inhibiting reproductive and metabolic disorder(1).

In animal study, green tea extract exhibited anti PCOs activity through induction of significant changes in the number of follicles and theca layer thicknes by attenuating the oxidative stress(1) such as levels of plasma glutathione (GSH) and plasma nitric oxide (NO)(2).Dr, Ghafurniyan H and the research team at the Kharazmi University also said," Green tea can be considered as a potentially effective drug for treatment of PCOS, insulin resistance,..."(2).

Furthermore, the drink also showed to reduce weight loss and maintenance body weight and body composition, a crucial important figure as women with PCOs(3).

Dr. Hursel R and the research team at the Maastricht University suggested that the effectiveness of Catechin- and caffeine-rich green teas in induced weight loss and weight maintenance after weight loss, probably due to its polyphenols in counteracted the decrease in metabolic rate through the expression of gut microbiota and gene(4).

Huanglian, one of most common Chinese herbal medicine used for detoxification with bitter and cold in nature, may be a missing link related to the treatment of polycystic ovarian syndrome. Berberine (BBR) is an isoquinoline derivative alkaloid extracted from huang lian, in a study of 89 subjects with PCOS and IR subject improved some of the metabolic and hormonal derangements through exhibiting the changes in body composition in obesity and dyslipidemia(5).

In comparison to metformin (MET), the phytochemical berberine showed decrease in waist circumference and waist-to-hip ratio, fasting plasma glucose, fasting insulin, homeostasis model assessment for IR, area under the curve of insulin, cholesterol and triglycerides as well as increase in high-density lipoprotein cholesterol and sex hormone-binding(6).

In combination with Letrozole for treatment of PCOs, the phytochemical berberine showed the effectiveness in lowering blood sugar levels in db/db mice and exerted anti-dyslipidemia in human(7).

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.

Immunohistochemical expression of VEGF may be associated to the pathophysiology of PCOS(8) as VEGF concentrations are found to increase in women with polycystic ovaries(9). Curcumin, according to the First Affiliated Hospital, Chongqing Medical University, lower the expression of VEGF in ovarian tissues of PCOS in high- and low-dose administrative rat model, and may have certain therapeutic effect on PCOS(10).

The rich golden liquid is the miraculous product made by bees using nectar from flowers. It is considered as one of healthy sweet food for replacing the use of white sugar and artificial sweetener by many people. According to the Republic of Korea, honey is also found in the formula of Kyung-Ok-Ko in Korean herbal medicine for treatment of polycystic ovarian syndrome throough reduced mRNA expression of pro-inflammatory cytokines and improved the DHEA-induced PCOS-like symptom(10).

The finding of the effectiveness of  the smoothie may serve as cornerstones of pharmaceutical target for further studies as well as a potential medication for treatment of polycystic ovarian syndrome(PCOs).

People who are at high risk of polycystic ovarian syndrome(PCOs) such as obesity, family history, genetic mutation genes,.....should drink at least one cup daily and people with PCOs should drink NO more than 4 cups a day, depending to digestive toleration.
Change of life style and diet pattern are also recommended.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

References
(1) The Effect of Green Tea Extract on Reproductive Improvement in Estradiol Valerate-Induced Polycystic OvarianSyndrome in Rat by Ghafurniyan H1, Azarnia M1, Nabiuni M1, Karimzadeh L1.(PubMed)
(2) Effects of Ramadan Fasting on Glucose Homeostasis, Lipid Profiles, Inflammation and Oxidative Stress in Women with Polycystic Ovary Syndrome in Kashan by Iran.Asemi Z1, Samimi M2, Taghizadeh M1, Esmaillzadeh A3.(PubMed)
(3) Effects of catechin enriched green tea on body composition by Wang H1, Wen Y, Du Y, Yan X, Guo H, Rycroft JA, Boon N, Kovacs EM, Mela DJ.(PubMed)
(4) Catechin- and caffeine-rich teas for control of body weight in humans by Hursel R1, Westerterp-Plantenga MS.(PubMed)
(5) A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome by Wei W1, Zhao H, Wang A, Sui M, Liang K, Deng H, Ma Y, Zhang Y, Zhang H, Guan Y(PubMed)
(6) A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome by Wei W, Zhao H, Wang A by Sui M, Liang K, Deng H, Ma Y, Zhang Y, Zhang H, Guan Y.(PubMed)
(7) Effect of Berberine on Hormonal and Metabolic Features in Obese Women With Polycystic Ovary Syndrome (PCOS)14:32 EST 15th January 2014 | BioPortfolio

(8) Role of vascular endothelial growth factor in women with PCO and PCOS: a systematic review. Peitsidis P1, Agrawal R.(PubMed)
(9) Serum vascular endothelial growth factor concentrations and ovarianstromal blood flow are increased in women with polycystic ovaries.
Agrawal R1, Sladkevicius P, Engmann L, Conway GS, Payne NN, Bekis J, Tan SL, Campbell S, Jacobs HS.(PubMed)
(10) Effect of curcumin on expression of VEGF in polycystic ovary syndrome rat models by WANG Lian-lian, LI Cong, MENG Jiang-ping, YANG Xi (Journal of Shanghai, Jiaotong Uncersity)

(11) Oriental medicine Kyung-Ok-Ko prevents and alleviates dehydroepiandrosterone-induced polycystic ovarian syndrome in rats by Jang M1, Lee MJ1, Lee JM2, Bae CS3, Kim SH4, Ryu JH5, Cho IH6.(PubMed)

Most Common Diseases of Ages of 50 Plus - Musculoskeletal disorders (MSDs): Cervical Stenosis (with Myleopathy) Treatment in Herbal Medicine perspective

Kyle J. Norton(Scholar)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) is medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).


                    Cervical Stenosis

Cervical Stenosis is defined as a degeneration of the structures of the spine as a result of aging causes of a slowly progressive condition of the cervical spinal cord. Spinal stenosis cause pressure on the spinal cord, which may lead to the symptoms of myelopathy. Cervical spinal stenosis with myelopathy is a common disease in elderly patients of male gender(2).

                                The Treatment

In herbal medicine perspective
The aim of herbal medicine is to relieve symptoms of Cervical Stenosis
1. Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belonging to Capsicum annuum, the family Solanaceae, native to sub-tropical and tropical regions. It has been used in traditional medicine to increases metabolism, enhance circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises and neuralgia, etc.
the non-pungent pepper CH-19 Sweet and of hot red pepper activates the sympathetic nervous system (SNS) and enhances thermogenesis as effectively as hot red pepper, ant that the heat loss effect due to CH-19 Sweet is weaker than that due to hot red pepper. Furthermore, we found that intake of CH-19 Sweet does not affect systolic BP or HR, while hot red pepper transiently elevates them, according to the study of “Effects of CH-19 Sweet, a non-pungent cultivar of red pepper, on sympathetic nervous activity, body temperature, heart rate, and blood pressure in humans” by Hachiya S, Kawabata F, Ohnuki K, Inoue N, Yoneda H, Yazawa S, Fushiki T.(a)

2. Valerian is a perennial flowering plant, in the genus Valeriana, belonging to the family Valerianaceae, native to Europe and parts of Asia. The herb has been used as a sedative and relaxing agent and to treat the liver, the urinary tract, the digestive tract problem, nerve conditions, etc.
In the evaluation of the effect of V. wallichii chemotype (patchouli alcohol) extract (DCME) and essential oil (VPAEO) on experimental models of nociception and to elucidate its possible mechanism of action, found that DCME and VPAEO (40 and 80 mg/kg, p.o.) significantly inhibited the number of writhings as compared to vehicle treated group. None of the doses of DCME and VPAEO exhibited any effect in tail flick model suggesting only peripheral analgesic activity. When studied for mechanism of action in acetic acid induced writhing, subeffective dose of essential oil significantly potentiated the effect of aspirin while no potentiation was seen in case of extract. These data suggest that essential oil VPAEO exerted peripheral analgesic via inhibition of prostaglandin synthesis, accoridng to “Elucidation of possible mechanism of analgesic action of Valeriana wallichii DC chemotype (patchouli alcohol) in experimental animal models” by Sah SP, Mathela CS, Chopra K.(b)

3. Harpagophytum procumbens (Devil’s claw), Salix alba (White willow bark), and Capsicum frutescens (Cayenne)
In a systematic review of randomized controlled trials to determine the effectiveness of herbal medicine compared with placebo, no intervention, or “standard/accepted/conventional treatments” for nonspecific low back pain, found that Harpagophytum procumbens (Devil’s claw), Salix alba (White willow bark), and Capsicum frutescens (Cayenne) seem to reduce pain more than placebo. Additional trials testing these herbal medicines against standard treatments will clarify their equivalence in terms of efficacy(c).

4. Etc.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/17341828
(b) http://www.ncbi.nlm.nih.gov/pubmed/21046983
(c) http://www.ncbi.nlm.nih.gov/pubmed/17202897

The Smoothie of Panax ginseng and Pomegranate for Erectile Dysfunction

Kyle J. Norton(Scholar), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for people with Erectile Dysfunction

Yield: 2 serving (about 8 ounce each)
1 3/4 cup pomegranate fruit or 1 cup of pomegranate juice

1 cup Panax ginseng drink, (Make from 2 grams of dried root, soaped into a cup of hot water  for 5 minutes, and set aside for cooling to room temperature)

1. Place  pomegranate fruit or  pomegranate juice, and Panax ginseng drink in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately


In the finding of a whole food and herb, comparing to the presently pharmaceutical medicine in use with little or no adverse effect(4), scientific communities have been looking into herbal ginseng which has been used extensively in traditional Chinese medicine for treatment of sexual dysfunction in both sexes.

According to statistic, in US alone, more than18 Million Men over 20 of ages are affected by Erectile Dysfunction and approximately 5% of 40-year-old men and between 15% and 25% of 65-year-old men experience ED on a long-term basis (National Institutes of Health). Astonishingly, lifetime use of ED medications was reported by 24% of men. Almost 69% of ED medication users reported obtaining ED medications from a physician. Fifty-nine percent of ED medication users reported taking the medications to enhance their sexual experience rather than to treat ED, which was marginally associated with stimulant use. according to Department of Veterans Affairs Puget Sound Health Care System, Seattle(1).

The comparison of the effect of erectile dysfunction with diabetes and men with erectile dysfunction due to other causes study indicated that the diseases not only affect Sexual Experience-Psychological Impact domains but also Emotional Life-Psychological Impact domain(2).

Ginseng, the King of Chinese herb, according to the literature in Chinese medicine found by Emperor Shen-Nung, the second of China's mythical emperors (3500-2600 BCE), through his treatise 'Shen Nung Benchau Jing', expressed the efficacy of herbal ginseng well being as a resemblance of human form and its rejuvenative and aphrodisiac properties. The use ofginseng for erectile dysfunction by Emperor Shen-Nung was unique for its time. It continues to hold parallels as a modern-day herbal aphrodisiac 5000 years on(3).

Panax notoginseng saponins (PNS), a major ingredient found in ginseng, in the study of erectile dysfunction and the underlying mechanism by using a rat diabetic erectile dysfunction model, showed a positive effect in deduction of oxidative stress cause of erectile dysfunction and restoration of functions of endothelial cells and smooth muscle cells in the penis, through reduced level of malondialdehyde and increased levels of superoxide dismutase, glutathione and Akt(5) and possibly via the NO/cGMP pathway(6).

In root-derived Korean red ginseng (KRG; Panax ginseng) study, researchers at the Yonsei University College of Medicine, found that GB0710 relaxes the penile corpus cavernosum smooth muscle (CCSM), through induced intracellular NO production in human microvascular endothelial cells by N(G)-monomethyl-L-arginine inhibition(7).

In a 119 men with mild-to-moderate ED participated in a multicenter, randomized, double-blind, parallel, placebo-controlled clinical study, oral administration of the SKGB extract improved all domains of sexual function(8)(9).

According to Chinese medicine, Herbal ginseng has been prescribed over 5000 years of history to promote yang and to improve cardiac function, short of breath, blood pressure. Panax ginseng can generates fluids and reduce thirst, to treat anxiety, insomnia, dizziness/headache, forgetfulness, impotence, diabetes, bleeding in the vagina not during period, etc.

Dr. Shergis JL and the researcher team at the School of Health Sciences and Health Innovations Research Institute-HIRi, RMIT University, told PubMed " Overall, the quality of Panax ginseng (andomized controlled trials ) RCT methodology has improved since the CONSORT checklist was introduced. However, more can be done to improve the methodological quality of, and reporting in, RCTs"(10)

But the use of herbal medicine in treating erectile dysfunction should be taken with care. Dr Ho CC and Dr. Tan HM. said" Many herbal therapies appear to have potential benefits, and similarly, the health risks of various phytotherapeutic compounds need to be elucidated. Properly designed human trials should be worked out and encouraged to determine the efficacy and safety of potential phytotherapies"(11). As the herb has shown mild adverseevents, such as dyspepsia, hot flash, insomnia, and constipation in dose depending manner(12).

Pomegranates is a fruit-bearing small tree, genus Punica, belongings to family Lythraceae, native to Iran, cultivated in Asian since ancient time.

In animal study, chronic oral administration of pomegranate juice (PJ) showd to increase intracavernous blood flow, improve erectile response and smooth muscle relaxation in ED, throough its effects in anti oxidative stress and free radical scavenging capacity(14), according to VA Boston Healthcare System and Boston University School of Medicine(14) and the Boston University School of Medicine and Veterans Affairs Boston Healthcare System, Boston(15).

Futhermore in 53 male patient with mild to moderate erectile dysfunction, randomized, placebo-controlled, double-blind, crossover study, Dr. Forest CP and the research team at the Male Clinic, Beverly Hills said," in GAQ scores after beverage consumption, 25 reported improvement after drinking pomegranate juice. Further, 17 subjects showed preference of one beverage to the other" and "... the possibility that larger cohorts and longer treatment periods may achieve statistical significance"(13).

Taking all together, Smoothie of Pomegranate and Panax ginseng drink may be a potent drink for reduced risk and treatment of Erectile Dysfunction
People who are at increased risk of Erectile Dysfunction due to family history, gene mutation, obesesity.....should drink at least one cup daily and people with Erectile Dysfunction should drink the juices no more than 4 serving a day, depending to digestive toleration.
Change of life style and diet pattern are also recommended.

Please note the smoothie is very hot in nature according traditional Chinese medicine, please make sure dietary consumption should include some cooling vegetables such as cucumber.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

Reference
(1) Erectile dysfunction medication use among men seeking substance abuse treatment by Horvath KJ, Calsyn DA, Terry C, Cotton A.(PubMed)
(2) Do impotent men with diabetes have more severe erectile dysfunction and worse quality of life than the general population of impotent patients? Results from the Exploratory Comprehensive Evaluation of Erectile Dysfunction (ExCEED) database by Penson DF, Latini DM, Lubeck DP, Wallace KL, Henning JM, Lue TF; Comprehensive Evaluation of Erectile Dysfunction (ExCEED) database(PubMed)
(3) The history of ginseng in the management of erectile dysfunction in ancient China (3500-2600 BCE) by Nair R, Sellaturay S, Sriprasad S.(PubMed)
(4) Erectile dysfunction: Viagra and other oral medications(Mayo clinic)
(5) Panax notoginseng Saponins Improve Erectile Function through Attenuation of Oxidative Stress, Restoration of Akt Activity and Protection of Endothelial and Smooth Muscle Cells in Diabetic Rats with Erectile Dysfunction by Li H, He WY, Lin F, Gou X.(PubMed)
(6) Panax notoginseng saponins improve the erectile dysfunction in diabetic rats by protecting the endothelial function of the penile corpus cavernosum by Lin F, Gou X.(PubMed)
(7) Effects of Korean ginseng berry extract (GB0710) on penile erection: evidence from in vitro and in vivo studies by Cho KS, Park CW, Kim CK, Jeon HY, Kim WG, Lee SJ, Kim YM, Lee JY, Choi YD.(PubMed)
(8) Effects of Korean ginseng berry extract on sexual function in men witherectile dysfunction: a multicenter, placebo-controlled, double-blind clinical study by Choi YD, Park CW, Jang J, Kim SH, Jeon HY, Kim WG, Lee SJ, Chung WS(PubMed)
(9) Effects of tissue-cultured mountain ginseng (Panax ginseng CA Meyer) extract on male patients with erectile dysfunction by Kim TH, Jeon SH, Hahn EJ, Paek KY, Park JK, Youn NY, Lee HL.(PubMed)
(10) Quality and risk of bias in Panax ginseng randomized controlled trials: a review by Shergis JL, Zhang AL, Zhou W, Xue CC.(PubMed)
(11) Rise of herbal and traditional medicine in erectile dysfunctionmanagement by Ho CC, Tan HM.(PubMed)
(12) Safety and tolerability of Panax ginseng root extract: a randomized, placebo-controlled, clinical trial in healthy Korean volunteers by Lee NH, Yoo SR, Kim HG, Cho JH, Son CG.(PubMed)

(13) Efficacy and safety of pomegranate juice on improvement of erectile dysfunction in male patients with mild to moderate erectile dysfunction: a randomized, placebo-controlled, double-blind, crossover study by Forest CP1, Padma-Nathan H, Liker HR(PubMed)

(14) Oxidative stress in arteriogenic erectile dysfunction: prophylactic role of antioxidants by Azadzoi KM1, Schulman RN, Aviram M, Siroky MB.(PubMed)

(15) Dietary antioxidants improve arteriogenic erectile dysfunction by Zhang Q1, Radisavljevic ZM, Siroky MB, Azadzoi KM.(PubMed)

Most common diseases of 50 plus: Types of Musculo-Skeletal disorders: Chronic Low back pain - The Causes

Kyle J. Norton(Scholar and Master of Nutrients)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

Types of Musculo-Skeletal disorders in elder(2)

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia
Low back pain is a Musculoskeletal disorders (MSDs, affecting over 80% of the population in US alone some points in their life. Chronic LBP (pain has persisted for longer than 3 months(1) prevalence in older adults was significantly higher than the 21-to-44-year age group (12.3% vs. 6.5%, p < .001). Older adults were more disabled, had longer symptom duration, and were less depressed(2)..Many older adults remain quite functional despite CLBP, and because age-related comorbidities often exist independently of pain (e.g., medical illnesses, sleep disturbance, mobility difficulty), the unique impact of CLBP is unknown. We conducted this research to identify the multidimensional factors that distinguish independent community dwelling older adults with CLBP from those that are pain-free(3).

                              Causes of chronic back pain

1. Trochanteric bursitis
Trochanteric bursitisis a clinical condition which simulates major hip diseases and low back pain, it may also mimic nerve root pressure syndrome(10).

2. Spinal stenosis
Spinal stenosis of aging population is at the higher risk of developing low back pain(11).

3. Chronic compression of the dorsal root ganglion (CCD) is associated with Chronic Low back pain(12).

4. Cauda equina syndrome (CES)
In the study to review the literature on the clinical progress in cauda equina syndrome (CES), including the epidemic history, pathogenesis, diagnosis, treatment policy and prognosis, showed that each type of CES has different typical signs and symptoms. Low back pain may be the most significant symptoms, accompanied by sciatica, lower extremities weakness, saddle or perianal hypoesthesia, sexual impotence, and sphincter dysfunction(13).

5. “Wear and tear” and “disc space loss” are associated with the development of Chronic Low back pain as a result of a progressive loss of structural integrity(14).

6. Osteoarthritis (OA), low back pain (LBP), and fibromyalgia (FM)
Patients with OA, LBP, and FM frequently demonstrate abnormalities of muscles, ligaments, or joints, the severity of such changes is only poorly correlated with clinical pain. Importantly, many patients with these chronic pain disorders show signs of central sensitization and abnormal endogenous pain modulation, according to the study by the Division of Rheumatology and Clinical Immunology, University of Florida(15).

7. Spondylitis
Spondylitis is associated with low back pain(16).

8. Extracellular matrix protein SPARC (Secreted Protein, Acidic, Rich in Cysteine)
Study of Alan Edwards Centre for Research on Pain, McGill University showed that aging mice develop anatomical and behavioral signs of disc degeneration and back pain, decreased SPARC expression and increased methylation of the SPARC promoter. In parallel, human subjects with back pain exhibit signs of disc degeneration and increased methylation of the SPARC promoter. Methylation of either the human or mouse SPARC promoter silences its activity in transient transfection assays(16a). Other study found that SPARC-null mice display behavioral signs consistent with chronic low back and radicular pain that we attribute to intervertebral disc degeneration(16b).
9. Etc.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html


Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca Sources
Red flags*
Recent significant trauma, Milder trauma if age is greater than 50 years, Unexplained weight loss, Unexplained fever, Immunosuppression, Previous or current cancer, Intravenous drug use, Osteoporosis, Chronic corticosteroid use, Age greater than 70 years, Focal neurological deficit, Duration greater than 6 week(a)
(a) http://en.wikipedia.org/wiki/Low_back_pain
(1) https://www.mja.com.au/journal/2004/180/2/management-chronic-low-back-pain
(2) http://jah.sagepub.com/content/22/8/1213.refs
(3) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2065872/
(10) http://www.ncbi.nlm.nih.gov/pubmed/15587030
(11) http://www.ncbi.nlm.nih.gov/pubmed/22828693
(12) http://www.ncbi.nlm.nih.gov/pubmed/23054639
(13) http://www.ncbi.nlm.nih.gov/pubmed/19493474
(14) http://www.ncbi.nlm.nih.gov/pubmed/20838269
(15) http://www.ncbi.nlm.nih.gov/pubmed/21833699
(16) http://www.ncbi.nlm.nih.gov/pubmed/21952186
(16a) http://www.ncbi.nlm.nih.gov/pubmed/21867537
(16b) http://www.ncbi.nlm.nih.gov/pubmed/20714283

The Smoothie of Cinnamon, Ginseng, and Skim Milk for treatment of Male Infertility

Kyle J. Norton(Scholar), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for treatment of infertility

Yield: 2 serving (about 8 ounce each)
1 cup of Skim Milk
1/4 tbsp cinnamon

1 cup Ginseng drink  (Make from 2 grams of dried root, soaped into a cup of hot water  for 5 minutes, and set aside for cooling to room temperature)
1. Place whole skim milk, cinnamon and ginseng drink in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of infertility has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.

Infertility is defined as inability of a couple to conceive after 12 months of unprotected sexual intercourse or can not carry the pregnancy to full term. It effects over 5 millions couple alone in the U. S. and many times more in the world, because of unawareness of treatments, only 10% seeks help from professional specialist
Cinnamon, a kitchen spice in many cultures, may be best known for its effect in reduced levels of blood glucose in diabetics and lipid peroxidation through its antioxidant activity(4) . Its underline mechanisms in enhancing fertility in both sexes are unknown.

Infertility is defined as the inability of a couple to conceive after 12 months of unprotected sexual intercourse or the cannot carry the pregnancy full term. It affects over 5 million couples alone in the U. S. and many times more in the world. Because of an unawareness of treatments, only 10% seek help from professional specialists. In fact, about 35% of infertility is caused by the male's inability to fertilize. 35% is caused by the female's inability to conceive, 10% attributes to both, and 10 % is considered a failure with an unknown cause.

A 45 women randomized, 26 women completed 3 months of the study, and 17 women completed the entire 6 months of the study, with Polycystic Ovary Syndrome, showed a positive effect in improvement of menstrual cyclicity associated to Luteal phase progesterone levels and ovulatory menses without altering insulin resistance or serum androgen levels(1). Cinnamaldehyde, a major chemical compound of cinnamon, also showed to enhance fertility through selectively induced progesterone production and inhibited production of testosterone and dehydroepiandrosterone in human adrenal cells(3).

Its extract in PCOs study not only showed to reduce insulin resistance in vitro and in vivo by increasing phosphatidylinositol 3-kinase activity in the insulin signaling pathway, but also improved menstrual cyclicity through significant reductions in insulin resistance(8).

In infertile male rat study conducted by Fırat University, long-term cinnamonbark oil(CPO) improved the effect on testicular oxidant-antioxidant balance and sperm quality with significantly decreasing the abnormal sperm rate and apoptotic germ cell count(2).
The study in male rat reproductive system induced by carbon tetrachloride (CCl4 ), the cinnamon bark oil(CPO), also showed a significant improvements in absolute weights of testis and epididymis, all sperm quality parameters, LPO level, apoptotic index and testicular(6)

Taken altogether, Cinnamon may be effective in promoting fertility in both sexes through enhancing the menstrual cycle in women and improving sperm performance in men. Unfortunately, according to DR. Georgakopoulou EA(6), Oral intake of Cinnamon may cause Stomatitis, and burning sensation in mouth with large amount. The traditional Chinese medicine also insisted that Overdoses of cinnamon can be toxic and damaged to liver(5).

Ginseng is a slow-growing perennial plants with fleshy roots, the genus Panax, belonging to the family Araliaceae. Depending to the climate where it grows, ginseng can be classified mainly into Panax ginseng Asian ginseng (root), Red ginseng, wild ginseng, American ginseng (root).

Ginseng as a king of all herb may represent a novel therapeutic strategies for the treatment of male reproductive diseases or disorder, recent study suggested(9).In a randomized, placebo-controlled, double-blind clinical study conducted by the Pusan National University School of Medicine, panax ginseng showed significant improvements in sperm concentrations, motility, morphology, and viability in all 80 male infertility patients(10).
According to Dr. Akram H and the research team at the Shahid Sadoughi University of Medical Sciences, also suggested that its counter part American ginseng can prevent the cytotoxic effects of CP on sperm quality factors(11).

Intake of milk and dairy products may also have a higher than normal influence with infertility in male subjects. According to the joint study of 155 men at the cademic medical center fertility clinic, lead by the Harvard School of Public Health, dairy intake of low-fat milk, particularly low-fat milk, is related to higher sperm concentration and progressive motility(12) and high consumption of full-fat dairy foods may cause harmful effects on semen quality(13).
In fact according to Dr. Mendiola J and the research team at the Instituto Bernabeu, higher intake of skimmed milk, fruits and vegetables are associated to have a positive affect semen quality in men(14).

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References

(1) Preliminary Evidence that Cinnamon Improves Menstrual Cyclicity in Women with Polycystic Ovarian Syndrome: a Randomized Controlled Trial by Kort DH1, Lobo RA.(PubMed)
(2) Effects of cinnamon (Cinnamomum zeylanicum) bark oil on testicular antioxidant values, apoptotic germ cell and sperm quality by Yüce A1, Türk G, Çeribaşi S, Sönmez M, Çiftçi M, Güvenç M.(PubMed)
(3) Selective stimulation by cinnamaldehyde of progesterone secretion in human adrenal cells by Iwaoka Y1, Hashimoto R, Koizumi H, Yu J, Okabe T.(PubMed)
(4) Preventive effect of cinnamon essential oil on lipid oxidation of vegetable oil by Keshvari M1, Asgary S, Jafarian-Dehkordi A, Najafi S, Ghoreyshi-Yazdi SM(PubMed)
(5) Popular #Herbs - #Dang Qui (Angelica sinensis)
(6) Chromium and polyphenols from cinnamon improve insulin sensitivity by Anderson RA.(PubMed)
(7) Effectiveness of cinnamon (Cinnamomum zeylanicum) bark oil in the prevention of carbon tetrachloride-induced damages on the male reproductive system by Yüce A1, Türk G, Çeribaşı S, Güvenç M, Çiftçi M, Sönmez M, Özer Kaya Ş, Çay M, Aksakal M.(PubMed)
(8) The effect of cinnamon extract on insulin resistance parameters in polycystic ovary syndrome: a pilot study by Wang JG1, Anderson RA, Graham GM 3rd, Chu MC, Sauer MV, Guarnaccia MM, Lobo RA.(PubMed)

(9) Ginseng and male reproductive function by Leung KW1, Wong AS1.(PubMed)

(10) Effects of Korean red ginseng on semen parameters in male infertility patients: A randomized, placebo-controlled, double-blind clinical study by Park HJ1, Choe S, Park NC.(PubMed)

(11) Beneficial effects of american ginseng on epididymal sperm analyses in cyclophosphamide treated rats by Akram H1, Ghaderi Pakdel F, Ahmadi A, Zare S.(PubMed)

(12) Dairy intake and semen quality among men attending a fertility clinic by Afeiche MC1, Bridges ND2, Williams PL3, Gaskins AJ4, Tanrikut C5, Petrozza JC6, Hauser R7, Chavarro JE8(PubMed)

(13) Dairy food intake in relation to semen quality and reproductive hormone levels among physically active young men by Afeiche M1, Williams PL, Mendiola J, Gaskins AJ, Jørgensen N, Swan SH, Chavarro JE.(PubMed)

(14) Food intake and its relationship with semen quality: a case-control study by Mendiola J1, Torres-Cantero AM, Moreno-Grau JM, Ten J, Roca M, Moreno-Grau S, Bernabeu R.(PubMed)

Most common diseases of 50 plus: Types of Musculo-Skeletal disorders: Chronic Low back pain - The Signs and Symptoms

Kyle J. Norton(Scholar and Master of Nutrients)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Musculoskeletal disorders (MSDs) are medical condition mostly caused by work related occupations and working environment, affecting patients’ muscles, joints, tendons, ligaments and nerves and developing over time. A community sample of 73 females and 32 males aged 85 and over underwent a standardised examination at home. Musculoskeletal pain was reported by 57% of those interviewed(1).

Types of Musculo-Skeletal disorders in elder(2)

1. Osteoarthritis
2. Gout
3. Rheumatoid Arthritis
4. Polymalagia Arthritis
5. Cervical myleopathy and spinal canal stenosis
6. Osteoporosis
7. Low back pain
8. Fibromyalgia
Low back pain is a Musculoskeletal disorders (MSDs, affecting over 80% of the population in US alone some points in their life. Chronic LBP (pain has persisted for longer than 3 months(1) prevalence in older adults was significantly higher than the 21-to-44-year age group (12.3% vs. 6.5%, p < .001). Older adults were more disabled, had longer symptom duration, and were less depressed(2)..Many older adults remain quite functional despite CLBP, and because age-related comorbidities often exist independently of pain (e.g., medical illnesses, sleep disturbance, mobility difficulty), the unique impact of CLBP is unknown. We conducted this research to identify the multidimensional factors that distinguish independent community dwelling older adults with CLBP from those that are pain-free(3).

I. Signs and symptoms
1. Pain has persisted for longer than 3 months as mentioned above
2. Degenerative disc disease
In a study to assess SPARC-null mice as an animal model of chronic lowback and/or radicular pain caused by degenerative disc disease, showed that
a. Movement-evoked discomfort
b. Hypersensitivity to cold stimuli(4)
3. Morning stiffness, as a result of inflammation due to aging causes of degenerated discs(5)
4. Sleep interruptions due to pain
5. Higher compressive axial and tensile radial strains(6)
6. Depression, anxiety disorders and adjustment disorders
In the study of 127 patients suffering from chronic back pain in multimodal inpatient pain therapy who were assessed by a psychologist, showed that there was a high prevalence of depression, anxiety disorders and adjustment disorders in patients with chronic back pain(7).
7. Pain interfered with daily living, depressivity, and quality of life(8).
8. Diabetic peripheral neuropathic pain, fibromyalgia, and chronicmusculoskeletal pain
due to chronic osteoarthritis (OA) pain and chronic low back pain (LBP)(9).
9. Metabolic syndrome
The prevalence of metabolic syndrome among chronic lower back painpatients was 36.2% (30.2% male, 38.6% female), according to the study by Department of Rehabilitation Medicine, Seoul Medical Center(9a)

10. Etc.
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

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(a) http://en.wikipedia.org/wiki/Low_back_pain
(1) https://www.mja.com.au/journal/2004/180/2/management-chronic-low-back-pain
(2) http://jah.sagepub.com/content/22/8/1213.refs
(3) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2065872/
(4) http://www.ncbi.nlm.nih.gov/pubmed/20714283
(5) http://www.ncbi.nlm.nih.gov/pubmed/17543240
(6) http://www.ncbi.nlm.nih.gov/pubmed/21337394
(7) http://www.ncbi.nlm.nih.gov/pubmed/23149491
(8) http://www.ncbi.nlm.nih.gov/pubmed/11845338
(9) http://www.ncbi.nlm.nih.gov/pubmed/22716295

The Smoothie of Cinnamon, Whole Food Papaya and Green Tea reduced Risk and Treatment of Diabetes

Kyle J. Norton(Scholar), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for people with inctreased risk of Diabetes and Diabetes

Yield: 2 serving (about 8 ounce each)
1 3/4 cup whole food papaya
1/4 tsp cinnamon

1 cup green tea drink (Make from 4 grams(2 tea bags) of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and set aside for cooling to room temperature)
1. Place whole food papaya, cinnamon and green tea drink in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for reduced risk and treatment of diabetes has encountered many obstacles, many ingredients showed initially the promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.

Diabetes is defined as a condition caused by insufficient insulin entering the bloodstream to regulate the glucose. It is either caused by cells in pancreas dying off or receptor sites clogged up by fat and cholesterol. In some cases,diabetes is also caused by allergic reactions of cells in the immune system

Cinnamon, a kitchen spicy in many cultures, may have gained many believers, including medical professions because of its anti diabetic effect, through regulating the blood glucose levels in healthy and diabetic subjects. According to herbalists, intake of 1/4 tsp. in the morning and evening may reduce the blood sugar significantly with little or no adverse effects.

The herb has been use in herbal and traditional medicine as anti-fungal and bacteria level to improve reproductive organ, prevent flatulence and intestinal cramping, treat indigestion, diarrhea, bad breath, headache, migraine, etc.(1).

According to the 2011 statistic from National Diabetes InformationClearinghouse (NDIC), among U.S. residents ages 65 years and older, 10.9 million, or 26.9 percent, had diabetes in 2010, about 215,000 people younger than 20 years had diabetes—type 1 or type 2—in the United States in 2010 and approximately, 1.9 million people ages 20 years or older were newly diagnosed with diabetes in 2010 in the United States.

In a total of 66 patients with type 2 diabetes study conducted by Xuhui District Central Hospital, showed a significant reduction of blood triglyceride levels in the low-dose group, after 3 months of oral administration(2)

Some researchers suggested that cinnamon extract may improve fasting blood glucose levels and glucose tolerance without altering the insulin secretion, through lower triglyceride and increased liver glycogen content and improved insulin action in liver tissues(3).

Dr. Kim SH and Dr. Choung SY. told PubMed "The effect of cinnamon in significantly increases insulin sensitivity, reduces serum, and hepatic lipids, and improves hyperglycemia and hyperlipidemia possibly by regulating the PPAR(in regulation of metabolism (carbohydrate, lipid, protein))-medicated glucose and lipid metabolism"(4)

In support of the above, chromium(Cr) and polyphenols found in cinnamon(Cinnamomon cassia) indicated a improvement of glucose, insulin, cholesterol and HbA1c(Glucose lab test) in patients with type 2 diabetesfollowing Cr supplementation, in a double-blind placebo-controlled study(7).

Unfortunately, according to the Western University of Health Sciences, consumption of cinnamon is associated with a statistically significant decrease in levels of fasting plasma glucose, but insisted that high degree of heterogeneity may limit the ability to apply these results to patient care, due to the unclear preferred dose and duration of therapy(5)

A randomized clinical trial in which 70 Patients with type II diabetesassigned randomly two groups (35 in cinnamon and 35 in placebo group for the testing of the effect of cinnamon on the glucose level in blood, indicated an insignificant effect of using cinnamon on glucose level of diabetic patients and the herb should not be recommended to patients with type II diabetes depending on further studies(6).

People with Type II Diabetes may also be thinking to add whole food papaya into their diet. the recent study suggested(7) ,
The finding not only showed the effectiveness of unripe pawpaw fruit (Carica papaya) in inhibition α-amylase, α-glucosidase, but also induced lipid peroxidation in a dose-dependent manner, in rat pancreas(7).
The key enzymes of α-amylase, α-glucosidase, involved in the digestion of carbohydrates, have been linked to onset of type 2 diabetes. Inhibition of these enzymes can significantly reduce the post-prandial increase of blood glucose and have been considered by therapists in use for management of blood glucose level in type 2 diabetic and borderline patients(8).

In streptozotocin-induced diabetic rats study, the aqueous extract of leaves of C. papaya administered strongly controlled blood glucose levels(9), through prevention of hepatocyte disruption, as well as accumulation of glycogen and lipids via its hypoglycemic and antioxidant effect(10) 

In a new study, conducted by the researchers at the Davis Heart and Lung Research Institute, fermented papaya preparation was tested whether it improves dermal wound healing outcomes in adult diabetic mice by preventing the risk of infections(11).
The result was astonishing, the fermentation not only up regulated the Sp1 DNA binding activity(modulating the cellular response to DNA damage) in Peripheral blood mononuclear cells (PBMC) but also the protein and mRNA expression of Rac2(regulates a number of cellular functions)(11).

A randomized controlled clinical trial conducted at the Cardiac Centre, ANDI Centre of Excellence for Biomedical and Biomaterials Research and Department of Biosciences University of Mauritius, suggested that oral administration of 6g FPP®/day for a period of 14 weeks could improve the general health status of several organs targeted by oxidative stress duringdiabetes and suggested that the supplement may be used in the management the complications of diabetes such as cardiovascular disease, neurological disease and other conditions worsened by overt inflammation and oxidative stress(12).

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate.

Green tea has ling been known for its effect on treatment of diabetes in ancient Chinese literature, probably due to green tea phytochemical polyphenols(14).

Dr. Solayman M and the research tea at the Universiti Sains Malaysia said, "Natural products containing high polyphenol levels can control carbohydrate metabolism by various mechanisms, such as protecting and restoring beta-cell integrity, enhancing insulin releasing activity, and increasing cellular glucose uptake"(15).

 In a total of 17,413 persons (6727 men and 10,686 women; 49% of the original study population) who were 40 to 65 years of age, daily drinking of green tea reduced risk of diabetes by 33%, especially in women and in overweight men(13).

Furthermore, intake of green tea of 150 ml green tea, three times a day for four weeks, has positive effect on insulin resistance and certain lipoproteins in type 2 DM, according to the Shahid Sadoughi University of Medical Science(16).

People who are at increased risk of diabetes due to family history, gene mutation, obesity.....should drink at least one serving daily and people with diabetes should drink no more than 4 serving a day, depending to digestive toleration.
Change of life style and diet pattern are also recommended.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

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References
(1) @Popular Herbs -Cinnamon
(2) Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes by Lu T, Sheng H, Wu J, Cheng Y, Zhu J, Chen Y.(PubMed)
(3) Cinnamon extract improves insulin sensitivity in the brain and lowers liver fat in mouse models of obesity by Sartorius T1, Peter A2, Schulz N3, Drescher A2, Bergheim I4, Machann J5, Schick F6, Siegel-Axel D2, Schürmann A3, Weigert C1, Häring HU1, Hennige AM(PubMed)
(4) Antihyperglycemic and antihyperlipidemic action of Cinnamomi Cassiae (Cinnamon bark) extract in C57BL/Ks db/db mice by Kim SH1, Choung SY.(PubMed)
(5) Cinnamon use in type 2 diabetes: an updated systematic review and meta-analysis by Allen RW1, Schwartzman E, Baker WL, Coleman CI, Phung OJ.(PubMed)
(6) The Effect of Cinnamon on Glucose of Type II Diabetes Patients by Hasanzade F1, Toliat M2, Emami SA3, Emamimoghaadam Z(PubMed)

(7) Inhibition of key enzymes linked to type 2 diabetes and sodium nitroprusside-induced lipid peroxidation in rat pancreas by water-extractable phytochemicals from unripe pawpaw fruit (Carica papaya) by Oboh G, Olabiyi AA, Akinyemi AJ, Ademiluyi AO.(PubMed)
(8) Natural products as alpha-amylase and alpha-glucosidase inhibitors and their hypoglycaemic potential in the treatment of diabetes: an update by Tundis R1, Loizzo MR, Menichini F.(PubMed)
(9) Antihyperglycemic and hypolipidemic activities of aqueous extract ofCarica papaya Linn. leaves in alloxan-induced diabetic rats by Maniyar Y, Bhixavatimath P.(PubMed)
(10) Hypoglycemic effect of Carica papaya leaves in streptozotocin-induced diabetic rats by Juárez-Rojop IE1, Díaz-Zagoya JC, Ble-Castillo JL, Miranda-Osorio PH, Castell-Rodríguez AE, Tovilla-Zárate CA, Rodríguez-Hernández A, Aguilar-Mariscal H, Ramón-Frías T, Bermúdez-Ocaña DY.(PubMed)
(11) Correction of aberrant NADPH oxidase activity in blood-derived mononuclear cells from type II diabetes mellitus patients by a naturally fermented papaya preparation by Dickerson R1, Deshpande B, Gnyawali U, Lynch D, Gordillo GM, Schuster D, Osei K, Roy S.(PubMed)
(12) Effects of a short term supplementation of a fermented papaya preparation on biomarkers of diabetes mellitus in a randomized Mauritian population by Somanah J1, Aruoma OI, Gunness TK, Kowelssur S, Dambala V, Murad F, Googoolye K, Daus D, Indelicato J, Bourdon E, Bahorun T.(PubMed)

(13) The relationship between green tea and total caffeine intake and risk for self-reported type 2 diabetes among Japanese adults by Iso H1, Date C, Wakai K, Fukui M, Tamakoshi A; JACC Study Group(PubMed)

(14) Polyphenols: Potential Future Arsenals in the Treatment of Diabetes by Solayman M, Ali Y, Alam F, Islam MA, Alam N, Khalil MI, Gan SH1(PubMed)

(15) Polyphenols: Potential Future Arsenals in the Treatment of Diabetes by Solayman M, Ali Y, Alam F, Islam MA, Alam N, Khalil MI, Gan SH1.(PubMed)

(16) The Effect of Green Tea versus Sour Tea on Insulin Resistance, Lipids Profiles and Oxidative Stress in Patients with Type 2 Diabetes Mellitus: A Randomized Clinical Trial by Mozaffari-Khosravi H1, Ahadi Z1, Fallah Tafti M2.(PubMed)