Saturday, December 19, 2015

The Smoothie of Cinnamon, Ginseng, and Skim Milk for treatment of Male Infertility

Kyle J. Norton(Scholar), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for treatment of infertility

Yield: 2 serving (about 8 ounce each)
1 cup of Skim Milk
1/4 tbsp cinnamon
1 cup Ginseng drink  (Make from 2 grams of dried root, soaped into a cup of hot water  for 5 minutes, and set aside for cooling to room temperature)
1. Place whole skim milk, cinnamon and ginseng drink in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of infertility has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.

Infertility is defined as inability of a couple to conceive after 12 months of unprotected sexual intercourse or can not carry the pregnancy to full term. It effects over 5 millions couple alone in the U. S. and many times more in the world, because of unawareness of treatments, only 10% seeks help from professional specialist
Cinnamon, a kitchen spice in many cultures, may be best known for its effect in reduced levels of blood glucose in diabetics and lipid peroxidation through its antioxidant activity(4) . Its underline mechanisms in enhancing fertility in both sexes are unknown.

Infertility is defined as the inability of a couple to conceive after 12 months of unprotected sexual intercourse or the cannot carry the pregnancy full term. It affects over 5 million couples alone in the U. S. and many times more in the world. Because of an unawareness of treatments, only 10% seek help from professional specialists. In fact, about 35% of infertility is caused by the male's inability to fertilize. 35% is caused by the female's inability to conceive, 10% attributes to both, and 10 % is considered a failure with an unknown cause.

A 45 women randomized, 26 women completed 3 months of the study, and 17 women completed the entire 6 months of the study, with Polycystic Ovary Syndrome, showed a positive effect in improvement of menstrual cyclicity associated to Luteal phase progesterone levels and ovulatory menses without altering insulin resistance or serum androgen levels(1). Cinnamaldehyde, a major chemical compound of cinnamon, also showed to enhance fertility through selectively induced progesterone production and inhibited production of testosterone and dehydroepiandrosterone in human adrenal cells(3).

Its extract in PCOs study not only showed to reduce insulin resistance in vitro and in vivo by increasing phosphatidylinositol 3-kinase activity in the insulin signaling pathway, but also improved menstrual cyclicity through significant reductions in insulin resistance(8).

In infertile male rat study conducted by Fırat University, long-term cinnamonbark oil(CPO) improved the effect on testicular oxidant-antioxidant balance and sperm quality with significantly decreasing the abnormal sperm rate and apoptotic germ cell count(2).
The study in male rat reproductive system induced by carbon tetrachloride (CCl4 ), the cinnamon bark oil(CPO), also showed a significant improvements in absolute weights of testis and epididymis, all sperm quality parameters, LPO level, apoptotic index and testicular(6)

Taken altogether, Cinnamon may be effective in promoting fertility in both sexes through enhancing the menstrual cycle in women and improving sperm performance in men. Unfortunately, according to DR. Georgakopoulou EA(6), Oral intake of Cinnamon may cause Stomatitis, and burning sensation in mouth with large amount. The traditional Chinese medicine also insisted that Overdoses of cinnamon can be toxic and damaged to liver(5).

Ginseng is a slow-growing perennial plants with fleshy roots, the genus Panax, belonging to the family Araliaceae. Depending to the climate where it grows, ginseng can be classified mainly into Panax ginseng Asian ginseng (root), Red ginseng, wild ginseng, American ginseng (root).

Ginseng as a king of all herb may represent a novel therapeutic strategies for the treatment of male reproductive diseases or disorder, recent study suggested(9).In a randomized, placebo-controlled, double-blind clinical study conducted by the Pusan National University School of Medicine, panax ginseng showed significant improvements in sperm concentrations, motility, morphology, and viability in all 80 male infertility patients(10).
According to Dr. Akram H and the research team at the Shahid Sadoughi University of Medical Sciences, also suggested that its counter part American ginseng can prevent the cytotoxic effects of CP on sperm quality factors(11).

Intake of milk and dairy products may also have a higher than normal influence with infertility in male subjects. According to the joint study of 155 men at the cademic medical center fertility clinic, lead by the Harvard School of Public Health, dairy intake of low-fat milk, particularly low-fat milk, is related to higher sperm concentration and progressive motility(12) and high consumption of full-fat dairy foods may cause harmful effects on semen quality(13).
In fact according to Dr. Mendiola J and the research team at the Instituto Bernabeu, higher intake of skimmed milk, fruits and vegetables are associated to have a positive affect semen quality in men(14).

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(1) Preliminary Evidence that Cinnamon Improves Menstrual Cyclicity in Women with Polycystic Ovarian Syndrome: a Randomized Controlled Trial by Kort DH1, Lobo RA.(PubMed)
(2) Effects of cinnamon (Cinnamomum zeylanicum) bark oil on testicular antioxidant values, apoptotic germ cell and sperm quality by Yüce A1, Türk G, Çeribaşi S, Sönmez M, Çiftçi M, Güvenç M.(PubMed)
(3) Selective stimulation by cinnamaldehyde of progesterone secretion in human adrenal cells by Iwaoka Y1, Hashimoto R, Koizumi H, Yu J, Okabe T.(PubMed)
(4) Preventive effect of cinnamon essential oil on lipid oxidation of vegetable oil by Keshvari M1, Asgary S, Jafarian-Dehkordi A, Najafi S, Ghoreyshi-Yazdi SM(PubMed)
(5) Popular #Herbs - #Dang Qui (Angelica sinensis)
(6) Chromium and polyphenols from cinnamon improve insulin sensitivity by Anderson RA.(PubMed)
(7) Effectiveness of cinnamon (Cinnamomum zeylanicum) bark oil in the prevention of carbon tetrachloride-induced damages on the male reproductive system by Yüce A1, Türk G, Çeribaşı S, Güvenç M, Çiftçi M, Sönmez M, Özer Kaya Ş, Çay M, Aksakal M.(PubMed)
(8) The effect of cinnamon extract on insulin resistance parameters in polycystic ovary syndrome: a pilot study by Wang JG1, Anderson RA, Graham GM 3rd, Chu MC, Sauer MV, Guarnaccia MM, Lobo RA.(PubMed)
(9) Ginseng and male reproductive function by Leung KW1, Wong AS1.(PubMed)
(10) Effects of Korean red ginseng on semen parameters in male infertility patients: A randomized, placebo-controlled, double-blind clinical study by Park HJ1, Choe S, Park NC.(PubMed)
(11) Beneficial effects of american ginseng on epididymal sperm analyses in cyclophosphamide treated rats by Akram H1, Ghaderi Pakdel F, Ahmadi A, Zare S.(PubMed)
(12) Dairy intake and semen quality among men attending a fertility clinic by Afeiche MC1, Bridges ND2, Williams PL3, Gaskins AJ4, Tanrikut C5, Petrozza JC6, Hauser R7, Chavarro JE8(PubMed)
(13) Dairy food intake in relation to semen quality and reproductive hormone levels among physically active young men by Afeiche M1, Williams PL, Mendiola J, Gaskins AJ, Jørgensen N, Swan SH, Chavarro JE.(PubMed)
(14) Food intake and its relationship with semen quality: a case-control study by Mendiola J1, Torres-Cantero AM, Moreno-Grau JM, Ten J, Roca M, Moreno-Grau S, Bernabeu R.(PubMed)

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