Sunday, December 20, 2015

The Smoothie of Panax ginseng and Pomegranate for Erectile Dysfunction

Kyle J. Norton(Scholar), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for people with Erectile Dysfunction

Yield: 2 serving (about 8 ounce each)
1 3/4 cup pomegranate fruit or 1 cup of pomegranate juice
1 cup Panax ginseng drink, (Make from 2 grams of dried root, soaped into a cup of hot water  for 5 minutes, and set aside for cooling to room temperature)

1. Place  pomegranate fruit or  pomegranate juice, and Panax ginseng drink in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

In the finding of a whole food and herb, comparing to the presently pharmaceutical medicine in use with little or no adverse effect(4), scientific communities have been looking into herbal ginseng which has been used extensively in traditional Chinese medicine for treatment of sexual dysfunction in both sexes.

According to statistic, in US alone, more than18 Million Men over 20 of ages are affected by Erectile Dysfunction and approximately 5% of 40-year-old men and between 15% and 25% of 65-year-old men experience ED on a long-term basis (National Institutes of Health). Astonishingly, lifetime use of ED medications was reported by 24% of men. Almost 69% of ED medication users reported obtaining ED medications from a physician. Fifty-nine percent of ED medication users reported taking the medications to enhance their sexual experience rather than to treat ED, which was marginally associated with stimulant use. according to Department of Veterans Affairs Puget Sound Health Care System, Seattle(1).

The comparison of the effect of erectile dysfunction with diabetes and men with erectile dysfunction due to other causes study indicated that the diseases not only affect Sexual Experience-Psychological Impact domains but also Emotional Life-Psychological Impact domain(2).

Ginseng, the King of Chinese herb, according to the literature in Chinese medicine found by Emperor Shen-Nung, the second of China's mythical emperors (3500-2600 BCE), through his treatise 'Shen Nung Benchau Jing', expressed the efficacy of herbal ginseng well being as a resemblance of human form and its rejuvenative and aphrodisiac properties. The use ofginseng for erectile dysfunction by Emperor Shen-Nung was unique for its time. It continues to hold parallels as a modern-day herbal aphrodisiac 5000 years on(3).

Panax notoginseng saponins (PNS), a major ingredient found in ginseng, in the study of erectile dysfunction and the underlying mechanism by using a rat diabetic erectile dysfunction model, showed a positive effect in deduction of oxidative stress cause of erectile dysfunction and restoration of functions of endothelial cells and smooth muscle cells in the penis, through reduced level of malondialdehyde and increased levels of superoxide dismutase, glutathione and Akt(5) and possibly via the NO/cGMP pathway(6).

In root-derived Korean red ginseng (KRG; Panax ginseng) study, researchers at the Yonsei University College of Medicine, found that GB0710 relaxes the penile corpus cavernosum smooth muscle (CCSM), through induced intracellular NO production in human microvascular endothelial cells by N(G)-monomethyl-L-arginine inhibition(7).

In a 119 men with mild-to-moderate ED participated in a multicenter, randomized, double-blind, parallel, placebo-controlled clinical study, oral administration of the SKGB extract improved all domains of sexual function(8)(9).

According to Chinese medicine, Herbal ginseng has been prescribed over 5000 years of history to promote yang and to improve cardiac function, short of breath, blood pressure. Panax ginseng can generates fluids and reduce thirst, to treat anxiety, insomnia, dizziness/headache, forgetfulness, impotence, diabetes, bleeding in the vagina not during period, etc.

Dr. Shergis JL and the researcher team at the School of Health Sciences and Health Innovations Research Institute-HIRi, RMIT University, told PubMed " Overall, the quality of Panax ginseng (andomized controlled trials ) RCT methodology has improved since the CONSORT checklist was introduced. However, more can be done to improve the methodological quality of, and reporting in, RCTs"(10)

But the use of herbal medicine in treating erectile dysfunction should be taken with care. Dr Ho CC and Dr. Tan HM. said" Many herbal therapies appear to have potential benefits, and similarly, the health risks of various phytotherapeutic compounds need to be elucidated. Properly designed human trials should be worked out and encouraged to determine the efficacy and safety of potential phytotherapies"(11). As the herb has shown mild adverseevents, such as dyspepsia, hot flash, insomnia, and constipation in dose depending manner(12).

Pomegranates is a fruit-bearing small tree, genus Punica, belongings to family Lythraceae, native to Iran, cultivated in Asian since ancient time.

In animal study, chronic oral administration of pomegranate juice (PJ) showd to increase intracavernous blood flow, improve erectile response and smooth muscle relaxation in ED, throough its effects in anti oxidative stress and free radical scavenging capacity(14), according to VA Boston Healthcare System and Boston University School of Medicine(14) and the Boston University School of Medicine and Veterans Affairs Boston Healthcare System, Boston(15).

Futhermore in 53 male patient with mild to moderate erectile dysfunction, randomized, placebo-controlled, double-blind, crossover study, Dr. Forest CP and the research team at the Male Clinic, Beverly Hills said," in GAQ scores after beverage consumption, 25 reported improvement after drinking pomegranate juice. Further, 17 subjects showed preference of one beverage to the other" and "... the possibility that larger cohorts and longer treatment periods may achieve statistical significance"(13).

Taking all together, Smoothie of Pomegranate and Panax ginseng drink may be a potent drink for reduced risk and treatment of Erectile Dysfunction
People who are at increased risk of Erectile Dysfunction due to family history, gene mutation, obesesity.....should drink at least one cup daily and people with Erectile Dysfunction should drink the juices no more than 4 serving a day, depending to digestive toleration.
Change of life style and diet pattern are also recommended.
Please note the smoothie is very hot in nature according traditional Chinese medicine, please make sure dietary consumption should include some cooling vegetables such as cucumber.

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(1) Erectile dysfunction medication use among men seeking substance abuse treatment by Horvath KJ, Calsyn DA, Terry C, Cotton A.(PubMed)
(2) Do impotent men with diabetes have more severe erectile dysfunction and worse quality of life than the general population of impotent patients? Results from the Exploratory Comprehensive Evaluation of Erectile Dysfunction (ExCEED) database by Penson DF, Latini DM, Lubeck DP, Wallace KL, Henning JM, Lue TF; Comprehensive Evaluation of Erectile Dysfunction (ExCEED) database(PubMed)
(3) The history of ginseng in the management of erectile dysfunction in ancient China (3500-2600 BCE) by Nair R, Sellaturay S, Sriprasad S.(PubMed)
(4) Erectile dysfunction: Viagra and other oral medications(Mayo clinic)
(5) Panax notoginseng Saponins Improve Erectile Function through Attenuation of Oxidative Stress, Restoration of Akt Activity and Protection of Endothelial and Smooth Muscle Cells in Diabetic Rats with Erectile Dysfunction by Li H, He WY, Lin F, Gou X.(PubMed)
(6) Panax notoginseng saponins improve the erectile dysfunction in diabetic rats by protecting the endothelial function of the penile corpus cavernosum by Lin F, Gou X.(PubMed)
(7) Effects of Korean ginseng berry extract (GB0710) on penile erection: evidence from in vitro and in vivo studies by Cho KS, Park CW, Kim CK, Jeon HY, Kim WG, Lee SJ, Kim YM, Lee JY, Choi YD.(PubMed)
(8) Effects of Korean ginseng berry extract on sexual function in men witherectile dysfunction: a multicenter, placebo-controlled, double-blind clinical study by Choi YD, Park CW, Jang J, Kim SH, Jeon HY, Kim WG, Lee SJ, Chung WS(PubMed)
(9) Effects of tissue-cultured mountain ginseng (Panax ginseng CA Meyer) extract on male patients with erectile dysfunction by Kim TH, Jeon SH, Hahn EJ, Paek KY, Park JK, Youn NY, Lee HL.(PubMed)
(10) Quality and risk of bias in Panax ginseng randomized controlled trials: a review by Shergis JL, Zhang AL, Zhou W, Xue CC.(PubMed)
(11) Rise of herbal and traditional medicine in erectile dysfunctionmanagement by Ho CC, Tan HM.(PubMed)
(12) Safety and tolerability of Panax ginseng root extract: a randomized, placebo-controlled, clinical trial in healthy Korean volunteers by Lee NH, Yoo SR, Kim HG, Cho JH, Son CG.(PubMed)
(13) Efficacy and safety of pomegranate juice on improvement of erectile dysfunction in male patients with mild to moderate erectile dysfunction: a randomized, placebo-controlled, double-blind, crossover study by Forest CP1, Padma-Nathan H, Liker HR(PubMed)
(14) Oxidative stress in arteriogenic erectile dysfunction: prophylactic role of antioxidants by Azadzoi KM1, Schulman RN, Aviram M, Siroky MB.(PubMed)
(15) Dietary antioxidants improve arteriogenic erectile dysfunction by Zhang Q1, Radisavljevic ZM, Siroky MB, Azadzoi KM.(PubMed)

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