Medical Advisor Journals

Wednesday, August 31, 2016

Women Health: The Obesity and Polycystic ovary syndrome Research and Studies of Low-Grade Chronic Inflammation in Polycystic Ovary Syndrome (PCOS)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Obesity is a medical condition of excess body fat accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese.

You can calculate your BMI index BMI= weight (kg)/ height (m2)

Polycystic Ovarian Syndrome is defined as endocrinologic diseases caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries as resulting of enlarged ovaries, leading to hormone imbalance( excessive androgen), resulting in male pattern hair development, acne,irregular period or absence of period, weight gain and effecting fertility. It effects over 5% of women population or 1 in 20 women.

The Studies of Low-Grade Chronic Inflammation in Polycystic Ovary Syndrome (PCOS)

Chronic low-grade subclinical inflammation has been increasingly recognized as an interposer in the endocrine, metabolic and reproductive disturbances that characterize the polycystic ovary syndrome (PCOS). Abdominal adiposity andobesity are often present in PCOS, According to study posted in PubMed, mounting evidence indicates that adipose tissue is involved in innate and adaptive immune responses. Continuous release of inflammatory mediators such as cytokines, acute phase proteins, and adipokines perpetuate the inflammatory condition associated with obesity in women with PCOS, possibly contributing to insulin resistance and other long-term cardiometabolic risk factors. Genetic variants in the genes encoding inflammation-related mediators underlie the development of PCOS and their interaction with environmental factors may contribute to the heterogeneous clinical phenotype of this syndrome.

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine

Chinese Food Therapy

The Best Way to prevent, treat your disease, including Obesity

and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination

Holistic System In Existence That Will Show You How To

Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Most Common Diseases of 50 Plus: Thyroid Disease : Euthyroid sick syndrome as a result of Sepsis - Treatments in Herbal medicine perspective

Thyroid disease

Thyroid disease is defined as a condition of malfunction of thyroid. Hyperthyroidism is a condition in which the thyroid gland is over active and produces too much thyroid hormones.

Euthyroid sick syndrome as a result of Sepsis

Sepsis is defined as a condition caused by chemicals released into the bloodstream to fight the infection trigger inflammation throughout the body as a result of severe infection(a)(b). according to the study by the University of Utah, sepsis is the commonest cause of admission to medical ICUs across the world. Mortality from sepsis continues to be high. Besides shock and multi-organ dysfunction occurring following the intense inflammatory reaction to sepsis, complications arising from sepsis-related immunoparalysis contribute to the morbidity and mortality from sepsis(c).

The Treatments

Treatments in herbal medicine perspective
1. Taraxacum coreanum
Taraxacum coreanum Nakaiis a dandelion native to Korea and is widely consumed as an edible and medicinal herb. Treatment of primary macrophages with Taraxacum coreanum chloroform fraction(TCC) in vitro significantly inhibited all of the inflammatory parameters measured, including LPS-induced NO and PGE2 production, iNOS and COX-2 expression, IκBα degradation, IKK phosphorylation, and MAPK and STAT1 activation. In a mouse model of LPS-induced septic shock, TCC inhibited the production of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6, and increased survival by 83%.Standard compounds (gallic acid, syringic acid) of Taraxacum coreanum were qualified by HPLC analysis, according to Kyung Hee University(62).

2. Chamaecyparis obtusa
β-thujaplicin, an active constituent from Chamaecyparis obtusa, has been shown to have acaricidal and antimicrobial effects. According to the study by the Chia-Nan University of Pharmacy and Science, the potential of β-thujaplicin in treatment of inflammation and sepsis. These effects occur through an efficient blockage of TNF-alpha and iNOS production. β-thujaplicin efficacy is comparable to that of indomethacin thus it can be a substitution but bear less depletion of PGE2, making this compound very promising in clinical applications(63).

3. Angelica sinensis
A low-molecular-weight (<10 kDa) fraction of A. sinensis extract significantly attenuated endotoxin-induced HMGB1 release in part through interfering with its cytoplasmic translocation in macrophage cultures. Prophylactic administration of an aqueous extract of A. sinensis significantly attenuated systemic HMGB1 accumulation in vivo, and conferred a dose-dependent protection against lethal endotoxemia. Furthermore, delayed administration of A. sinensis extract beginning 24 h after CLP attenuated systemic HMGB1 accumulation, and significantly rescued mice from lethal sepsis. Taken together, these data suggest that A. sinensis contains water-soluble components that exert protective effects against lethal endotoxemia and experimental sepsis in part by attenuating systemic accumulation of a late proinflammatory cytokine, HMGB1, according to the New York University School of Medicine(64).

4. Green tea
Intraperitoneal administration of EGCG protected mice against lethal endotoxemia, and rescued mice from lethal sepsis even when the first dose was given 24 hours after cecal ligation and puncture. The therapeutic effects were partly attributable to: 1) attenuation of systemic accumulation of proinflammatory mediator (e.g., HMGB1) and surrogate marker (e.g., IL-6 and KC) of lethal sepsis; and 2) suppression of HMGB1-mediated inflammatory responses by preventing clustering of exogenous HMGB1 on macrophage cell surface, according to the study by the North Shore University Hospital-New York University School of Medicine(65).

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/9086580
(b)http://www.merckmanuals.com/professional/endocrine_and_metabolic_disorders/thyroid_disorders/euthyroid_sick_syndrome.html
(c) http://en.wikipedia.org/wiki/Euthyroid_sick_syndrome
(d) http://www.ncbi.nlm.nih.gov/pubmed/8028742
(62) http://www.ncbi.nlm.nih.gov/pubmed/23261487
(63) http://www.ncbi.nlm.nih.gov/pubmed/22507316
(64) http://www.ncbi.nlm.nih.gov/pubmed/16424112
(65) http://www.ncbi.nlm.nih.gov/pubmed/17987129

Women Health: Menstrual Disorders -Menorrhagia - Types and Symptoms

Types of menorrhagia

1. Primary menorrhagia
Girls are especially prone to anovulatory cycles in the 2 years after the first menstrual as a result of the immature reproductive organs, which can lead to disturbance of protaglandins production, causing pains and heavy period.
2. Secondary menorrhagia
Secondary menorrhagia is a result of as a result of disruption of normal hormonal regulation of periods or disorders of certain reproductive organs, that lead menstrual cramps and pain and excessive bleeding.

The Symptoms

1. Spotting or bleeding between menstrual periods
2. Excessive menstrual bleeding
3. Heavy period
4. Symptoms of anemia (caused by loss of iron in the blood)
5. Constant pain in the lower abdomen during menstrual period
6. Irregular menstrual periods
7. Period with heavy period occurs almost in every period.
8. Blood loss from 30 to 44 milliliters
9. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease,
particular in treatment of menstrual disorder in Women Health

Tuesday, August 30, 2016

Phytochemicals in Foods- The Effects of Apiole

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Apiole

Apiol, a phytochemical monophenols, is also known as parsley apiol, apiole or parsley camphor found mostly in celery, parsley seeds. It has been used as medicine to treat menstrual disorders.

Health Benefits
1. Antinociceptive and 2. anti-inflammatory effects
In the investigation of Essential oil from the roots of I. lanceolatum, obtained by hydrodistillation, was analysed by GC-MS, including myristicin (17.63%), α-asarone (17.23%), methyl isoeugenol (11.19%), apiol (8.82%) and isolongifolol (5.94%) found that the essential oil showed significantly antinociceptive and anti-inflammatory effects. The results indicate that the essential oil may contain the bioactive components of I. lanceolatum. This is the first report on the chemistry, antinociceptive and anti-inflammatory activities of I. lanceolatum, according to the study of "Chemical composition, antinociceptive and anti-inflammatory properties of essential oil from the roots of Illicium lanceolatum" by Liang J, Huang B, Wang G.(1)

3. Antimicrobial and 4. antiproliferative activity
In the observation of Acetone extracts of leaves, flowers, and stems of A. sicula L., including apiol and myristicin and its effect on cancer cell lines found that antimicrobial activity of acetone extracts was carried out against bacterial and fungal strains and antiproliferative activity against a group of human cancer cell lines (K-562, NCI-H460, and MCF-7), according to "Antimicrobial and antiproliferative activity of Athamanta sicula L. (Apiaceae)" by Stefano VD, Pitonzo R, Schillaci D.(2)

5. Antifungal activity
In demonstration of the extracts prepared from 10 plant species and their effect on Paracoccidioidomycosis (PCM) which is a systemic granulomatous disease caused by Paracoccidioides brasiliensis Almeida (Onygenales) found that the major components of the hexane fraction of Piper regnellii were 1-methoxy-4-(1-propenyl) benzene (21.94%) and apiol (21.29%). The activities of these fractions against P. brasiliensis without evidence of cytotoxicity to macrophages justify their investigation as a potential source of new chemical agents for the treatment of PCM, according to the study of "Antifungal activity of extracts of some plants used in Brazilian traditional medicine against the pathogenic fungus Paracoccidioides brasiliensis" by Johann S, Cisalpino PS, Watanabe GA, Cota BB, de Siqueira EP, Pizzolatti MG, Zani CL, de Resende MA.(3)

6. Carcinogenesis
In the research of Alkoxy derivatives of allylbenzene, including safrole, estragole, methyleugenol, myristicin, dill apiol, and parsley apiol and their effects on DNA found that safrole, estragole, methyleugenol, myristicin, dill apiol, and parsley apiolare capable of altering the DNA in these cells and thus may contribute to human carcinogenesis, according to the study of "DNA adducts from alkoxyallylbenzene herb and spice constituents in cultured human (HepG2) cells" by Zhou GD, Moorthy B, Bi J, Donnelly KC, Randerath K.(4)

7. Cercaricidal effect
In analyzing the composition of the essential oil of the fresh aerial parts of Apium graveolens var. secalinum at its flowering stage, including the main components in the oil are: alpha- and beta-pinene, myrcene, limonene, cis-beta-ocimene, gamma-terpinene, cis-allo-ocimene, trans-farnesene, humulene, apiol, beta-selinene, senkyunolide and neocnidilide and its cercaricidal effect found that the essential oil showed in addition to a cercaricidal effect also a chemotactic effect, according to the study of "The essential oil of Apium graveolens var. secalinum and its cercaricidal activity" by Saleh MM, Zwaving JH, Malingré TM, Bos R.(5)

8. Etc.

Do not use Apiole without consulting with related field specialist as it can be toxic if overdosed

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine

Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/21999530
(2) http://www.ncbi.nlm.nih.gov/pubmed/21472076
(3) http://www.ncbi.nlm.nih.gov/pubmed/20645716
(4) http://www.ncbi.nlm.nih.gov/pubmed/17948277
(5) http://www.ncbi.nlm.nih.gov/pubmed/4080514

Children Health: Attention Deficit Disorder (ADHD/ADD) -Treatments In Herbal medicine perspective - Chamomile

Attention Deficit Disorder (ADHD/ADD) also known as attention deficit hyperactivity disorder is a chronic disease occurs in certain age and years of a children, defined as a condition with characteristics of co-existence of attentional problems and hyperactivity. It effects about 5% of the all children in the world with boys have 3-4 times higher risk than girl. Over one third of children with ADHD will have continued symptoms existed into their adult life.

The Herbal medicine - Chamomile

a. Anti-allergic activity
The methanol extract of Matricaria recutita L. has shown anti-allergic activity by inhibition of histamine release from mast cells, according to the study of "Anti-allergic activity of German chamomile (Matricaria recutita L.) in mast cell mediated allergy model" by Chandrashekhar VM, Halagali KS, Nidavani RB, Shalavadi MH, Biradar BS, Biswas D, Muchchandi IS.(81)

b. Neuroprotective activity
German chamomile methanol extract (GCME) has shown shown the ability to treat neuroprotective activity by significant decrease in lipid peroxidation (LPO) and increase in the superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and total thiol levels, against AlF₄⁻- and may be used to treat oxidative brain damage, according to the study of "Neuroprotective activity of Matricaria recutita against fluoride-induced stress in rats" by Ranpariya VL, Parmar SK, Sheth NR, Chandrashekhar VM.(82)

c. Anxiety
Matricaria recutita (chamomile) extract therapy has exerted the modest anxiolytic activity in patients with mild to moderate generalized anxiety disorder, according to the study of "A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxietydisorder" by Amsterdam JD, Li Y, Soeller I, Rockwell K, Mao JJ, Shults J.(83)

d. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease,
particular in treatment of menstrual disorder in Women Health

Pregnancy Miracle
Reverse Infertility And Get Pregnant Naturally
Using Holistic Ancient Chinese Medicine

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

References
(81) http://www.ncbi.nlm.nih.gov/pubmed/21651969
(82) http://www.ncbi.nlm.nih.gov/pubmed/21599496
(83) http://www.ncbi.nlm.nih.gov/pubmed/19593179

Most Common Diseases of Ages of 50 Plus: Cancers - Types of factor that cause cancers

1. Aging: Due to weakened immune system as a result of wear and tear over years. Some researchers suspected that free radicals may be one of contributors.

2. Tobacco :Due to chemical causes of cells alternation.

3. Sunlight :Damage to skin as result of ultra violet.

4. ionizing radiation: Any types of hazard chemicals cause of gene mutation.

5. Virus and bacteria: As mentioned above.

6. Hormones: Abnormal production of certain hormones can increase the risk of sex-related cancers.

7. Family history : Check above.

8. Etc.
Chinese Food Therapy
The Best Way to prevent, treat your disease,
particular in treatment of menstrual disorder in Women Health

Phytochemicals for Treatment of Choriocarcinoma and Hydatidiform Mole(Tumors and Placenta)

Phytochemials are defined as a group of chemical compound found naturally in plants, including fruits, vegetables, beans, grains, etc. Many studies have proven that they can because of certain phytochemicals, but for what ever reason, there are either no clinical trials follow through or the studies can not make to stage of clinical trials. Do not expect the pharmateutical or foods industrial companies to pay for the researches, as the discovery of the phytochemicals to cure cancers can only dampen the profits of both industries as phytochemicals can not be patented.

Cancer is a class of diseases in which a group of cells growing and multiplying disordered and uncontrollable way in our body, have become progressively worse and damaged other healthy tissues, sometimes spreads to other organs in the body via lymph or blood and results may be in death.
Food intake can help to prevent and treat cancers.

Choriocarinma

Cancer of Choriocarinma is a malignant and aggressive cancer, started from the abnormal and uncontrollable cells growth in the trophoblatistic tissue, that is part of embryo and normally become the placenta as a result of something going wrong during pregnancy due to random chance.
Placenta is the organ by which the fetus received nutrients and oxygen from the mother.

Molar pregnancy or Hydatidiffrom mole
Molar pregnancy or Hydatidiffrom mole is also started from the trophoblastic tissue, normally is non cancerous but sometimes, it may invade the uterine wall (invasive mole) as a result of a sperm fusing with an with nucleus or something going wrong during pregnancy causing forming of a mass resembling the bunch of grape.

The two types of molar pregnancy are complete molar and partial molar pregnancy.

a. Complete mole pregnancy happens when a single sperm combining with an egg which is deficient with lost its DNA. The sperm that would otherwise fertilize the egg are then left to reduplicate themselves to form a complete 46 chromosome set.

Generally no fetus results from a complete molar pregnancy. Complete hydatidiform moles have a higher risk of developing into choriocarcinoma and happened in 1 out of 1200 pregnancy.

b. Partial mole pregnancy
A partial mole pregnancy occurs when two separate sperm fertilize the same egg, resulting of the nucleus containing one maternal set of genes and two paternal sets. With a partial molar pregnancy, there may result an actual fetus and placenta but fetus is most likely to develop into a partial mole.
Types of foods to prevent and treat Choriocarcinoma and Hydatidiform Mole

Types of foods to prevent and treat Hydatidiform Mole
1. Carnot
Retinoic acid, a types of vitamin A found abundantly in carrot has exerted the protective effect against
Hydatidiform Mole. At clinical trial as many as 67 cases met the requirements for the study. Two cases were lost from observation and three experienced pregnancy. The incidence rate of malignant trophoblastic disease in the control group was 28.6%, and in the therapy group was 6.3%. No difference was found in the changes of SGOT and SGPT levels of the therapy group compared with the control group. The rate of malignant trophoblastic disease (MTD) was reduced in the group receiving vitamin A therapy(1).

2. Chinese cucumber
Trichosanthin found abundantly in Chinese cucumber has been found to be protective against hydatidiform mole."During 1972-1986, 44 of 52 patients (84.6%) with hydatidiform mole were treated successfully with trichosanthin. Of these, 38 (73.1%) had complete spontaneous evacuation and 6 (11.5%) incomplete evacuation. The average time for evacuation of hydatidiform mole was 4.5 +/- 1.64 days. The amount of bleeding was less than 100 ml in 33 patients (75%), while that in 2 of the patients with incomplete evacuation was more than 300 ml. Malignant changes occurred in two of the 44 patients (4.5%). The malignant rate was similar to that (4-12.5, P greater than 0.05) of prophylactic chemotherapy" Dr. Lu PX and Dr. Jin YC. at Shanghai Second Medical University said(2)

3. Kiwifruit
Vitamin C and E found in high amount in Kiwifruit is said to be effective in fighting against hydatidiform mole (CHM). In the study to determine the oxidative status and antioxidative status of plasma of patients with complete hydatidiform mole(CHM) and to compare these values with normal pregnancy, showed that total antioxidant potential (TAOP) of plasma was significantly lower in patients withhydatidiform mole than in healthy pregnant women [mean (SD) values were 511.9 (105.8) and 571.7 (109.4) micromol Trolox equiv./L respectively (p <0.05)]. In contrast, mean (SD) total peroxide level of plasma was significantly higher in the patients [21.8 (6.4) micromol H2O2/L] than in healthy pregnant women [15.6 (6.4) micromol H2O2/L (p <0.001)]. The mean oxidative stress index level was significantly higher in patients with CHM than in healthy pregnant women [4.43 (1.70) versus 2.92 (1.50) respectively (p <0.001)] and concluded that Patients with CHM are exposed to oxidative stress, which may have a role in the pathogenesis of the disease. Supplementation with antioxidative vitamins such as C and E could be considered in treatment(3).

4. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease,
particular in treatment of menstrual disorder in Women Health

Sources
(1) http://www.ncbi.nlm.nih.gov/pubmed/20843153
(2) http://www.ncbi.nlm.nih.gov/pubmed/2164464
(3) http://www.ncbi.nlm.nih.gov/pubmed/14691728