Lung toxicity or pulmonary toxicity refers to the toxicity induced by the side effects of the lung in patients under chemotherapy or radiotherapy.
The most common drugs associated with lung toxicity used for the treatment of cancer include Arsenic trioxide (Trisenox®) Bleomycin (Blenoxane®)1 Idarubicin (Idamycin®).
However, lung toxicity is also caused by inhaling chemical compounds, the most famous (infamous) example is pulmonary toxicity due to asbestos. air pollution and airborne particulate matter produced by car traffic, overland traffic (trucks), industrial production facilities, and cigarette smoking.
Symptoms of lung damage or toxicity are a shortage of breath, breathlessness during exercise, fatigue dry cough Shortness of breath, particularly the symptoms that worsen when lying on your back breath.
Acute pulmonary toxicity, the damage to the lungs that resolves with a short period of time by addressing the cause.
Conventionally, most common treatments of lung toxicity are the use of
* Corticosteroids to decrease inflammation and relieve the cough and pain
*Narcotics to reduce pain medications and promote breathing center
* Oxygen therapy to increase oxygen in the blood and prevent shortness of breath.
In severe cases, patients may be sent to the hospital for pulmonary (lung) rehabilitation.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a natural compound for the treatment of lung toxicity scientists evaluated the protective effects of curcumin on lipid peroxidation and antioxidants status in bronchoalveolar lavage fluid (BALF) and bronchoalveolar lavage (BAL) of a nicotine-treated animal model.
Wistar rats selected to the study were induced lung toxicity by subcutaneous injection of nicotine at a dose of 2.5 mg/kg body weight (5 days a week, for 22 weeks) and following by administration of curcumin (80 mg/kg body weight) given simultaneously by intragastric intubation for 22 weeks.
Before injecting curcumin, injection of nicotine rats showed the increased biochemical marker enzymes, lipid peroxides in BALF and BAL accompanied by a significant decrease in the levels of antioxidants in the lung.
Following the treatment of curcumin, infected rats showed a significantly lowered the biochemical marker enzymes, lipid peroxidation and enhanced the antioxidant status.
Based on the results, researchers said, "The results of the present study suggest that curcumin exerts its protective effect against nicotine-induced lung toxicity by modulating the biochemical marker enzymes, lipid peroxidation and augmenting antioxidant defense system".
In order to reveal more information about turmeric detoxed activity, researchers examined the protective role of curcumin and a synthetic analog of curcumin (BDMC-A) on nicotine-induced oxidative stress.
Male albino rats of Wistar strain selected to the study induced lung toxicity by subcutaneous injection of nicotine at a dose of 2.5 mg/kg body weight (five days a week, for 22 weeks) and followed by the treatment of curcuminoids given simultaneously by intragastric intubation for 22 weeks.
Nicotine-treated groups before injection of curcumin showed increased oxidative stress, as evidenced by lipid peroxidation indices.
Injection of curcumin and BDMC-A not only restored the antioxidant status which was decreased in the nicotine-treated group.
Based on the findings, researchers said, "The present study suggests that BDMC-A exerts its protective effect by modulating the extent of lipid peroxidation and augmenting the antioxidant defense system".
Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention of lung toxicity, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin ameliorates oxidative stress during nicotine-induced lung toxicity in Wistar rats by Kalpana C1, Menon VP. (PubMed)
(2) Comparative effects of curcumin and its synthetic analogue on tissue lipid peroxidation and antioxidant status during nicotine-induced toxicity by Kalpana C1, Sudheer AR, Rajasekharan KN, Menon VP. (PubMed)
Tuesday, April 7, 2020
Monday, April 6, 2020
Green tea Polyphenols, the Potential Candidate for Treatment of Spinal Muscular Atrophy, Scientists Find
Scientists may have found a beverage which processes the ability to protect the central nervous system against the onset of spinal muscular atrophy, some studies suggested.
Spinal muscular atrophy (SMA) is a rare neuromuscular disorder affected the part of the nervous system that controls voluntary muscle movement due to the loss of motor neurons and progressive muscle wasting.
The disease is caused by a mutation in the SMN1 gene on chromosome 5. In some cases, the disease is also associated with a mutation in an X-chromosome gene called UBE1 causes X-linked SMA.
Depending on the disease severity, patients with SMA may experience symptoms of muscle weakness and decreased muscle tone, limited mobility, breathing problem, problems eating and swallowing, delayed gross motor skill and spontaneous tongue movements.
Green tea, a precious drink processes numbers of health benefits known to almost everyone in Asia and the Western world.
In the investigation to reexamine, the laboratory-based evidence suggest that purified polyphenol compounds such as resveratrol, found naturally in red grapes, epigallocatechin galate from green tea and curcumin from turmeric, might be useful for the treatment of various inherited neuromuscular diseases, including spinal muscular atrophy, researchers at the RJAH Orthopaedic Hospital launched an investigation to evaluate the scientific evidence related to the known molecular effects that these polyphenols have on different models of inherited neuromuscular disease, with particular attention to problems with the validity of in vitro evidence.
Application of polyphenols demonstrated the molecular effects on different models of inherited neuromuscular disease,
Polyphenols, in vitro, exerts a significant effect on cells through metal ion chelation in cell-culture media.
Dr. Fuller HR, the lead author after taking into account co and confounders said, "Polyphenols could be an attractive approach to therapy for the inherited neuromuscular disease, especially since they may be safer to use on young children, compared with some of the other drug candidates".
Additionally, in the assessment of Epigallocatechin-3-gallate (EGCG), a major component of green tea polyphenols effect on neuroprotection, researchers at The Second Hospital of Hebei Medical University found that injection of EGCG exerts substantial protection of motor neuron by regulating glutamate level in organotypic culture of rat spinal cord.
Further analysis suggested EGCG blocks the glutamate excitotoxicity caused by threohydroxyaspartate, an inhibitor of glutamate transporter not by its antioxidant activity but other unknown mechanisms. As another antioxidant could not regulate the glutamate level under the same condition in another study.
These results suggested that EGCG may be a potential therapeutic candidate for neurodegenerative diseases involving glutamate excitotoxicity, including SMA.
Taken altogether, green tea purified polyphenols may be considered an adjunct therapy combined with conventional medicine for the treatment of various inherited neuromuscular diseases, including spinal muscular atrophy
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Naturally occurring plant polyphenols as potential therapies for inherited neuromuscular diseases by Fuller HR1, Humphrey EL, Morris GE. (PubMed)
(3) Epigallocatechin-3-gallate protects motor neurons and regulates glutamate level by Yu J1, Jia Y, Guo Y, Chang G, Duan W, Sun M, Li B, Li C.(PubMed)
Spinal muscular atrophy (SMA) is a rare neuromuscular disorder affected the part of the nervous system that controls voluntary muscle movement due to the loss of motor neurons and progressive muscle wasting.
The disease is caused by a mutation in the SMN1 gene on chromosome 5. In some cases, the disease is also associated with a mutation in an X-chromosome gene called UBE1 causes X-linked SMA.
Depending on the disease severity, patients with SMA may experience symptoms of muscle weakness and decreased muscle tone, limited mobility, breathing problem, problems eating and swallowing, delayed gross motor skill and spontaneous tongue movements.
Green tea, a precious drink processes numbers of health benefits known to almost everyone in Asia and the Western world.
In the investigation to reexamine, the laboratory-based evidence suggest that purified polyphenol compounds such as resveratrol, found naturally in red grapes, epigallocatechin galate from green tea and curcumin from turmeric, might be useful for the treatment of various inherited neuromuscular diseases, including spinal muscular atrophy, researchers at the RJAH Orthopaedic Hospital launched an investigation to evaluate the scientific evidence related to the known molecular effects that these polyphenols have on different models of inherited neuromuscular disease, with particular attention to problems with the validity of in vitro evidence.
Application of polyphenols demonstrated the molecular effects on different models of inherited neuromuscular disease,
Polyphenols, in vitro, exerts a significant effect on cells through metal ion chelation in cell-culture media.
Dr. Fuller HR, the lead author after taking into account co and confounders said, "Polyphenols could be an attractive approach to therapy for the inherited neuromuscular disease, especially since they may be safer to use on young children, compared with some of the other drug candidates".
Additionally, in the assessment of Epigallocatechin-3-gallate (EGCG), a major component of green tea polyphenols effect on neuroprotection, researchers at The Second Hospital of Hebei Medical University found that injection of EGCG exerts substantial protection of motor neuron by regulating glutamate level in organotypic culture of rat spinal cord.
Further analysis suggested EGCG blocks the glutamate excitotoxicity caused by threohydroxyaspartate, an inhibitor of glutamate transporter not by its antioxidant activity but other unknown mechanisms. As another antioxidant could not regulate the glutamate level under the same condition in another study.
These results suggested that EGCG may be a potential therapeutic candidate for neurodegenerative diseases involving glutamate excitotoxicity, including SMA.
Taken altogether, green tea purified polyphenols may be considered an adjunct therapy combined with conventional medicine for the treatment of various inherited neuromuscular diseases, including spinal muscular atrophy
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Naturally occurring plant polyphenols as potential therapies for inherited neuromuscular diseases by Fuller HR1, Humphrey EL, Morris GE. (PubMed)
(3) Epigallocatechin-3-gallate protects motor neurons and regulates glutamate level by Yu J1, Jia Y, Guo Y, Chang G, Duan W, Sun M, Li B, Li C.(PubMed)
Sunday, April 5, 2020
Herbal Cascara Sagrada (Rhamnus purshiana), The Best for the Prevention and Treatment of Liver cancer
Herbal Cascara sagrada processed a bioactive compound emodin may have a significant and potential effect in reducing the risk and treatment of liver cancer, according to studies.
Liver cancer is a medical and chronic condition caused by irregular cell growth in the liver tissues, due to the alternation of cell DNA.
The liver organ is one of the organs with a lack of nerve tissue, therefore liver cancer does not induce pain until the later stage.
At the advanced stage of liver cancer, the cancer cell may travel a distance away to infect other tissues and organs, leading to secondary metastasis.
According to the statistics provided by the Canadian Cancer Society, every year, approximately, 1,900 men and 580 women are diagnosed with liver cancer, causing the death of 950 men and 270 women.
In 2017, 2,500 Canadians were diagnosed with liver cancer and 1,200 Canadians died from liver cancer.
Compared to the early stage of other cancer, the 5 years survival rate in the early stage diagnosis is only 31% and 43% of people with liver cancer diagnosed at stage 0 and 1.
The exact causes of liver cancer are unknown. However, chronic infection with hepatitis virus, cirrhosis, genetic preposition, a medical condition of diabetes, nonalcoholic fatty liver disease and excessive alcohol consumption are some of the most prevalent risk factors of liver cancer, epidemiologically.
Dr. Chuang SC, the lead scientist in the concern of excessive alcohol drinking in risk of liver cancer, wrote, "Compared to individuals who never drank or drank at very low frequencies, the meta-relative risk (mRR) forever drinkers was 1.29 (95% confidence interval, CI 1.16-1.42) and 1.46 (95% CI 1.27-1.65) for case-control studies".
And, "The dose-response relation between alcohol and liver cancer was apparent with RR = 1.08 (95% CI 1.04-1.11) for 12 g/day (~1 drink), 1.54 (95% CI 1.36-1.74) for 50 g/day, 2.14 (95% CI 1.74-2.62) for 75 g/day, 3.21 (95% CI 2.34-4.40) for 100 g/day, and 5.20 (95% CI 3.25-8.29) for 125 g/day of alcohol consumption".
The finding clearly suggested, one alcoholic drink per day (~12 g/day) may be associated with 1.1 times higher liver cancer risk and risk of liver cancer increases proportionally to the volume intake per day.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America. The herbal bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc..
The chemical constituents of Cascara Sagrada include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A, B, C and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones palmidin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.
Researchers on finding a natural compound for the treatment of liver cancer examined the effect of emodin, a bioactive ingredient isolated from herbal Cascara Sagrada against CXCL12-CXCR4 signaling cascade which plays an important role in the process of invasion and metastasis of liver cancer.
Where The CXCL12/CXCR4 axis is a pathway involved in tumor progression, angiogenesis, metastasis, and survival.
Injection of emodin inhibited the expression of CXCR4 in a dose and time-dependent manner in HCC cells.
Treatment of emodin demonstrated a better effect compared to the pharmacological proteasome and lysosomal inhibitors on the decrease in CXCR4 expression.
The suppression of CXCR4 expression was attributed to several mechanisms, including the inhibition of cancer cells mRNA expression, a protein associated with cancer cell proliferation and production of antigens by innate immunity.
Furthermore, emodin treatment significantly suppressed metastasis to the lungs in an orthotopic HCC mice model and CXCR4 expression in tumor tissues.
In other human cancers cell lines, emodin-induced apoptosis in HepG2 cells through cell cycle arrest.
According to the Western blot data, emodin inhibited cancer cell growth through a set of mechanisms, including cell degradation and protein associated with cell death programming.
Moreover, application emodin increased the expression in the initiation of cytotoxicity against HepG2 without causing harm to the nearby healthy cells.
Additionally, emodin increased the protein p53 associated with tumor suppression and decreased the protein involved in cancer cell proliferation in HepG2 cells.
These results suggest that emodin induces apoptosis in the liver cancer cell line through a multifaceted complex cascade of events.
Taken altogether, herbal Cascara Sagrada processed a major bioactive compound emodin may be considered a functional remedy for the prevention and treatment of liver cancer, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Emodin suppresses migration and invasion through the modulation of CXCR4 expression in an orthotopic model of human hepatocellular carcinoma by Manu KA, Shanmugam MK, Ong TH, Subramaniam A, Siveen KS, Perumal E, Samy RP, Bist P, Lim LH, Kumar AP, Hui KM, Sethi G.(PubMed)
(2) Emodin regulates apoptotic pathway in human liver cancer cells by Yu JQ, Bao W, Lei JC.(PubMed)
(3) Apoptosis by aloe-emodin is mediated through down-regulation of calpain-2 and ubiquitin-protein ligase E3A in human hepatoma Huh-7 cells by Jeon W, Jeon YK, Nam MJ.(PubMed)
(4) Alcohol consumption and liver cancer risk: a meta-analysis by Chuang SC1, Lee YC, Wu GJ, Straif K, Hashibe M. (PubMed)
Liver cancer is a medical and chronic condition caused by irregular cell growth in the liver tissues, due to the alternation of cell DNA.
The liver organ is one of the organs with a lack of nerve tissue, therefore liver cancer does not induce pain until the later stage.
At the advanced stage of liver cancer, the cancer cell may travel a distance away to infect other tissues and organs, leading to secondary metastasis.
According to the statistics provided by the Canadian Cancer Society, every year, approximately, 1,900 men and 580 women are diagnosed with liver cancer, causing the death of 950 men and 270 women.
In 2017, 2,500 Canadians were diagnosed with liver cancer and 1,200 Canadians died from liver cancer.
Compared to the early stage of other cancer, the 5 years survival rate in the early stage diagnosis is only 31% and 43% of people with liver cancer diagnosed at stage 0 and 1.
The exact causes of liver cancer are unknown. However, chronic infection with hepatitis virus, cirrhosis, genetic preposition, a medical condition of diabetes, nonalcoholic fatty liver disease and excessive alcohol consumption are some of the most prevalent risk factors of liver cancer, epidemiologically.
Dr. Chuang SC, the lead scientist in the concern of excessive alcohol drinking in risk of liver cancer, wrote, "Compared to individuals who never drank or drank at very low frequencies, the meta-relative risk (mRR) forever drinkers was 1.29 (95% confidence interval, CI 1.16-1.42) and 1.46 (95% CI 1.27-1.65) for case-control studies".
And, "The dose-response relation between alcohol and liver cancer was apparent with RR = 1.08 (95% CI 1.04-1.11) for 12 g/day (~1 drink), 1.54 (95% CI 1.36-1.74) for 50 g/day, 2.14 (95% CI 1.74-2.62) for 75 g/day, 3.21 (95% CI 2.34-4.40) for 100 g/day, and 5.20 (95% CI 3.25-8.29) for 125 g/day of alcohol consumption".
The finding clearly suggested, one alcoholic drink per day (~12 g/day) may be associated with 1.1 times higher liver cancer risk and risk of liver cancer increases proportionally to the volume intake per day.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America. The herbal bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc..
The chemical constituents of Cascara Sagrada include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A, B, C and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones palmidin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.
Researchers on finding a natural compound for the treatment of liver cancer examined the effect of emodin, a bioactive ingredient isolated from herbal Cascara Sagrada against CXCL12-CXCR4 signaling cascade which plays an important role in the process of invasion and metastasis of liver cancer.
Where The CXCL12/CXCR4 axis is a pathway involved in tumor progression, angiogenesis, metastasis, and survival.
Injection of emodin inhibited the expression of CXCR4 in a dose and time-dependent manner in HCC cells.
Treatment of emodin demonstrated a better effect compared to the pharmacological proteasome and lysosomal inhibitors on the decrease in CXCR4 expression.
The suppression of CXCR4 expression was attributed to several mechanisms, including the inhibition of cancer cells mRNA expression, a protein associated with cancer cell proliferation and production of antigens by innate immunity.
Furthermore, emodin treatment significantly suppressed metastasis to the lungs in an orthotopic HCC mice model and CXCR4 expression in tumor tissues.
In other human cancers cell lines, emodin-induced apoptosis in HepG2 cells through cell cycle arrest.
According to the Western blot data, emodin inhibited cancer cell growth through a set of mechanisms, including cell degradation and protein associated with cell death programming.
Moreover, application emodin increased the expression in the initiation of cytotoxicity against HepG2 without causing harm to the nearby healthy cells.
Additionally, emodin increased the protein p53 associated with tumor suppression and decreased the protein involved in cancer cell proliferation in HepG2 cells.
These results suggest that emodin induces apoptosis in the liver cancer cell line through a multifaceted complex cascade of events.
Taken altogether, herbal Cascara Sagrada processed a major bioactive compound emodin may be considered a functional remedy for the prevention and treatment of liver cancer, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Emodin suppresses migration and invasion through the modulation of CXCR4 expression in an orthotopic model of human hepatocellular carcinoma by Manu KA, Shanmugam MK, Ong TH, Subramaniam A, Siveen KS, Perumal E, Samy RP, Bist P, Lim LH, Kumar AP, Hui KM, Sethi G.(PubMed)
(2) Emodin regulates apoptotic pathway in human liver cancer cells by Yu JQ, Bao W, Lei JC.(PubMed)
(3) Apoptosis by aloe-emodin is mediated through down-regulation of calpain-2 and ubiquitin-protein ligase E3A in human hepatoma Huh-7 cells by Jeon W, Jeon YK, Nam MJ.(PubMed)
(4) Alcohol consumption and liver cancer risk: a meta-analysis by Chuang SC1, Lee YC, Wu GJ, Straif K, Hashibe M. (PubMed)
Saturday, April 4, 2020
Chamomile, The best Whole herb Medicine in Expression of Sedative Activities
Chamomile, the most frequently used medical plant maybe the next generation of the whole herb to act as a sedative agent in treating patients with sleep disorders.
A quasi-experimental clinical trial, included 77 cases of elderly hospitalized in nursing homes, showed that oral administration of chamomile extract has sedative properties in sleep quality.
Sedation is a form of medicine in induced calm and sleep.
The herbal medicine is also known as camomile, the common name of many species daisy-like plants in the family Asteraceae, used in traditional medicine as antispasmodic and anti-inflammatory constituents and to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.
In support of the sedative effect, chamomile cream also is found to reduce episiotomy pain sedately in primiparous women, according to a triple-blind clinical trial performed on 114 eligible women at Ommolbanin Hospital in Mashhad, Iran in 2014.
Dr. McKay DL said, " Chamomile has moderate antioxidant and antimicrobial activities, and significant antiplatelet activity Animal model studies indicate potent antiinflammatory action, some antimutagenic and cholesterol-lowering activities, as well as antispasmodic and anxiolytic effects" and "(Unfortunately) However, human studies are limited, and clinical trials examining the purported sedative properties of chamomile tea are absent."
In fact, in the investigated hypnotic activities of chamomile and passiflora extracts using sleep-disturbed model rats, researchers at the Okayama University insisted, chamomile extract at a dose of 300 mg/kg exerted significantly decrease sleep latency.
The study also suggested chamomile extract is a herb having benzodiazepine-like hypnotic activity.
Taking all together, Chamomile may be helpful to aid calm and sleep through its sedative effects, but intake of the correct amount should only be given by qualified herbalist
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Investigation effect of oral chamomilla on sleep quality in elderly people in Isfahan: A randomized control trial by Abdullahzadeh M1, Matourypour P2, Naji SA1.(PubMed)
(2) The Effect of Chamomile Cream on Episiotomy Pain in Primiparous Women: A Randomized Clinical Trial by Aradmehr M1, Azhari S2, Ahmadi S3, Azmoude E4.(PubMed)
(3) Hypnotic activities of chamomile and passiflora extracts in sleep-disturbed rats by Shinomiya K1, Inoue T, Utsu Y, Tokunaga S, Masuoka T, Ohmori A, Kamei C.(PubMed)
A quasi-experimental clinical trial, included 77 cases of elderly hospitalized in nursing homes, showed that oral administration of chamomile extract has sedative properties in sleep quality.
Sedation is a form of medicine in induced calm and sleep.
The herbal medicine is also known as camomile, the common name of many species daisy-like plants in the family Asteraceae, used in traditional medicine as antispasmodic and anti-inflammatory constituents and to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.
In support of the sedative effect, chamomile cream also is found to reduce episiotomy pain sedately in primiparous women, according to a triple-blind clinical trial performed on 114 eligible women at Ommolbanin Hospital in Mashhad, Iran in 2014.
Dr. McKay DL said, " Chamomile has moderate antioxidant and antimicrobial activities, and significant antiplatelet activity Animal model studies indicate potent antiinflammatory action, some antimutagenic and cholesterol-lowering activities, as well as antispasmodic and anxiolytic effects" and "(Unfortunately) However, human studies are limited, and clinical trials examining the purported sedative properties of chamomile tea are absent."
In fact, in the investigated hypnotic activities of chamomile and passiflora extracts using sleep-disturbed model rats, researchers at the Okayama University insisted, chamomile extract at a dose of 300 mg/kg exerted significantly decrease sleep latency.
The study also suggested chamomile extract is a herb having benzodiazepine-like hypnotic activity.
Taking all together, Chamomile may be helpful to aid calm and sleep through its sedative effects, but intake of the correct amount should only be given by qualified herbalist
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Investigation effect of oral chamomilla on sleep quality in elderly people in Isfahan: A randomized control trial by Abdullahzadeh M1, Matourypour P2, Naji SA1.(PubMed)
(2) The Effect of Chamomile Cream on Episiotomy Pain in Primiparous Women: A Randomized Clinical Trial by Aradmehr M1, Azhari S2, Ahmadi S3, Azmoude E4.(PubMed)
(3) Hypnotic activities of chamomile and passiflora extracts in sleep-disturbed rats by Shinomiya K1, Inoue T, Utsu Y, Tokunaga S, Masuoka T, Ohmori A, Kamei C.(PubMed)
Friday, April 3, 2020
Herbal Turmeric, the Best Functional Herb Which Processes Anti Diseases Associated with Chronic Low Grade Inflammation Potential
Inflammation is a natural response induced by the immune system in which the white blood cells in the first line of defense try to destroy the harmful pathogens before they can enter the body to multiply in the acute phase of infection
However, overproduction of pro-inflammatory cytokines in this phase can cause damage to the nearby healthy cells, leading abnormal production of collagen ratio in the initiation of scars forming.
Most pathogens are stopped in the acute phase of infection, depending on the location and the size of the wound and tissues damage.
If the immune system can not kill off all invaded pathogens with a set of period of time, it will compromise, leading to the low-grade chronic inflammation with the persistent production of pro-inflammatory cytokines in the affected area.
Long-term low-grade inflammation ultimately leads to tissues and organs damage, inducing a number of chronic illness, including diabetes and cardiovascular disease.
Symptoms of low-grade chronic inflammation include body pain as in arthritis, constant fatigue and insomnia as in cancer, depression, anxiety and mood disorders due to pain. gastrointestinal complications like constipation, diarrhea, and acid reflux, unintended weight loss or gain depending on the infected tissues and organs.
According to statistics, chronic inflammatory diseases affects approximately 350 million people worldwide and nearly 43 million people in the United States or almost 20% of the population. The prevalence of diseases associated with chronic inflammation is anticipated to increase persistently for the next 30 years, causing a financial burden on the economy and health care sector.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native in demagogical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a natural compound for the treatment of diseases associated with chronic inflammation, including cancers, researchers examined the effects of the turmeric through its bioactive components.
According to the review of previous studies, turmeric oil, present in turmeric, can enhance the bioavailability of curcumin.
In other words, essential oil isolated from turmeric in the form of curcumin-free turmeric (CFT) components is more effective for the treatment of chronic inflammatory disease compared to other extracts.
In the components analysis, turmerin, turmerone, elemene, furanodiene, curdione, bisacurone, cyclocurcumin, calebin A, and germacrene were all contributed to the efficacy of the curcumin-free turmeric (CFT).
In examining the effect of ar-turmerone (ATM) and turmerones (TUR, a mixture of 5 sesquiterpenes including ATM) against disease associated with inflammation, researchers found that both CUR and ATM inhibited lipopolysaccharide (LPS)-induced expression of inducible forms of inflammation by exhibiting the production of free radicals and protein involved overexpression proinflammatory cytokines.
Furthermore, ATM prevented LPS-induced translocation of certain inflammatory genes.
In a colitis model, oral administration of TUR significantly protected the large bowel against 2% dextran sulfate sodium (DSS)-induced shortening of the large bowel by 52-58% and colon carcinogenesis.
Moreover, at a low dose, TUR markedly suppressed adenoma multiplicity by 73%, compared to the range of 63-69% of CUR.
Also, the combination of CUR and TUR at both low and high doses showed a complete abolish of tumor formation.
Based on the findings, Murakami A, the lead scientist in the chronic inflammatory disease team wrote, "we consider that its use in combination with CUR may become a powerful method for prevention of inflammation-associated colon carcinogenesis".
Taken altogether, turmeric in the form of essential oil, CUR, and TUR may be considered herbal remedies for the prevention and treatment of diseases associated with chronic inflammation, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric by Aggarwal BB1, Yuan W, Li S, Gupta SC. (PubMed)
(2) Curcumin combined with turmerones, essential oil components of turmeric, abolishes inflammation-associated mouse colon carcinogenesis by Murakami A1, Furukawa I, Miyamoto S, Tanaka T, Ohigashi H. (PubMed)
However, overproduction of pro-inflammatory cytokines in this phase can cause damage to the nearby healthy cells, leading abnormal production of collagen ratio in the initiation of scars forming.
Most pathogens are stopped in the acute phase of infection, depending on the location and the size of the wound and tissues damage.
If the immune system can not kill off all invaded pathogens with a set of period of time, it will compromise, leading to the low-grade chronic inflammation with the persistent production of pro-inflammatory cytokines in the affected area.
Long-term low-grade inflammation ultimately leads to tissues and organs damage, inducing a number of chronic illness, including diabetes and cardiovascular disease.
Symptoms of low-grade chronic inflammation include body pain as in arthritis, constant fatigue and insomnia as in cancer, depression, anxiety and mood disorders due to pain. gastrointestinal complications like constipation, diarrhea, and acid reflux, unintended weight loss or gain depending on the infected tissues and organs.
According to statistics, chronic inflammatory diseases affects approximately 350 million people worldwide and nearly 43 million people in the United States or almost 20% of the population. The prevalence of diseases associated with chronic inflammation is anticipated to increase persistently for the next 30 years, causing a financial burden on the economy and health care sector.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native in demagogical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
With an aim to find a natural compound for the treatment of diseases associated with chronic inflammation, including cancers, researchers examined the effects of the turmeric through its bioactive components.
According to the review of previous studies, turmeric oil, present in turmeric, can enhance the bioavailability of curcumin.
In other words, essential oil isolated from turmeric in the form of curcumin-free turmeric (CFT) components is more effective for the treatment of chronic inflammatory disease compared to other extracts.
In the components analysis, turmerin, turmerone, elemene, furanodiene, curdione, bisacurone, cyclocurcumin, calebin A, and germacrene were all contributed to the efficacy of the curcumin-free turmeric (CFT).
In examining the effect of ar-turmerone (ATM) and turmerones (TUR, a mixture of 5 sesquiterpenes including ATM) against disease associated with inflammation, researchers found that both CUR and ATM inhibited lipopolysaccharide (LPS)-induced expression of inducible forms of inflammation by exhibiting the production of free radicals and protein involved overexpression proinflammatory cytokines.
Furthermore, ATM prevented LPS-induced translocation of certain inflammatory genes.
In a colitis model, oral administration of TUR significantly protected the large bowel against 2% dextran sulfate sodium (DSS)-induced shortening of the large bowel by 52-58% and colon carcinogenesis.
Moreover, at a low dose, TUR markedly suppressed adenoma multiplicity by 73%, compared to the range of 63-69% of CUR.
Also, the combination of CUR and TUR at both low and high doses showed a complete abolish of tumor formation.
Based on the findings, Murakami A, the lead scientist in the chronic inflammatory disease team wrote, "we consider that its use in combination with CUR may become a powerful method for prevention of inflammation-associated colon carcinogenesis".
Taken altogether, turmeric in the form of essential oil, CUR, and TUR may be considered herbal remedies for the prevention and treatment of diseases associated with chronic inflammation, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric by Aggarwal BB1, Yuan W, Li S, Gupta SC. (PubMed)
(2) Curcumin combined with turmerones, essential oil components of turmeric, abolishes inflammation-associated mouse colon carcinogenesis by Murakami A1, Furukawa I, Miyamoto S, Tanaka T, Ohigashi H. (PubMed)
Thursday, April 2, 2020
Ginger, The Best Remedy for the Prevention and Treatment of Dysmenorrhea
Ginger may be the next generation of natural whole food for the prevention and treatment of menstrual pain, some scientists found.
Dysmenorrhea is a menstrual pain is pain occurred around a few days before menstruation begins.
The symptom normally lasts less than three days.
There are 2 types of dysmenorrhea
* Primary dysmenorrhea is the painful period with no other condition occurred most in the adolescence, affecting over 90% of women in the prime time of their reproductive years. In adolescence, some researchers suggested the symptoms are associated with the immature reproductive organs.
* Secondary dysmenorrhea is the painful period associated with the disorder in the woman's reproductive organs, such as endometriosis, adenomyosis, uterine fibroids, or infection.
Some women affected by the painful period may experience symptoms of It occurs in your lower abdominal pain can be felt in the hips, lower back, or thighs.
Other common symptoms may include nausea, vomiting, diarrhea, lightheadedness, headache, or fatigue.
There is no cure for dysmenorrhea. Nonsteroidal anti-inflammatory drugs (NSAIDs), the most common treatment for both primary and secondary dysmenorrhea may be effective, however, the drugs can induce some serious side effects, including liver or kidney problems. and hypertension.
If you are currently using conventional medicine for the treatment of dysmenorrhea, please sure you know all the side effects for the preventive measure.
.
In the use of diet therapy for the prevention and treatment of dysmenorrhea, Dr. Dina Abadi Bavil, the lead scientist said, "Given the scores obtained on the lifestyle questionnaire, significant differences were observed between the groups with and without dysmenorrhea in terms of eating behavior (p=0.008), physical activity (p=0.011), stress (p=0.041), and social relationships".
These results clearly suggested that a healthy diet and lifestyle play important roles in the prevention
and treatment of dysmenorrhea
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
On findings of a natural ingredient or whole food for the prevention and treatment of dysmenorrhea in the replacement of conventional medicine without inducing side effects, researchers examine the effects of ginger on primary dysmenorrhea, through searching the database of medical literature online.
Six selected studies were reviewed by 2 authors independently.
Ginger appeared more effective for reducing pain severity than placebo.
Ginger was found as effective as those of mefenamic acid (an NSAID).
The finding point to one conclusion, oral ginger could be an effective treatment for menstrual pain in dysmenorrhea.
Dr. Daily JW, the lead scientists in another search to find the evidence of ginger for treating primary dysmenorrhea launched an investigation by looking into the database of 12 medical libraries.
Seven met specific selection criteria were included in the review.
Four of the RCTs compared the therapeutic efficacy of ginger with placebo during the first 3-4 days of the menstrual cycle and were included in the meta-analysis.
The results of the in-depth differentiation showed that ginger processes a significant effect in reducing the Pain Visual Analogue Scale (PVAS) in subjects having primary dysmenorrhea.
Six RCTs out of 7 exhibited low to moderate of the risk of bias.
These results of the RCTs strongly indicated the suggestive evidence for the effectiveness of 750-2000 mg ginger powder during the first 3-4 days of the menstrual cycle for primary dysmenorrhea.
Taken altogether, ginger may be considered a functional remedy for the prevention and treatment of painful periods with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(2) Efficacy of Oral Ginger (Zingiber officinale) for Dysmenorrhea: A Systematic Review and Meta-Analysis by Chen CX1, Barrett B2, Kwekkeboom KL3. (PubMed)
(3) Efficacy of Ginger for Alleviating the Symptoms of Primary Dysmenorrhea: A Systematic Review and Meta-analysis of Randomized Clinical Trials by Daily JW1, Zhang X2, Kim DS2, Park S2. (PubMed)
(4) Comparison of lifestyles of young women with and without primary dysmenorrhea by Dina Abadi Bavil,1 Mahrokh Dolatian,2 Zohreh Mahmoodi,3,4 and Alireza Akbarzadeh Baghban. (PMC)
Dysmenorrhea is a menstrual pain is pain occurred around a few days before menstruation begins.
The symptom normally lasts less than three days.
There are 2 types of dysmenorrhea
* Primary dysmenorrhea is the painful period with no other condition occurred most in the adolescence, affecting over 90% of women in the prime time of their reproductive years. In adolescence, some researchers suggested the symptoms are associated with the immature reproductive organs.
* Secondary dysmenorrhea is the painful period associated with the disorder in the woman's reproductive organs, such as endometriosis, adenomyosis, uterine fibroids, or infection.
Some women affected by the painful period may experience symptoms of It occurs in your lower abdominal pain can be felt in the hips, lower back, or thighs.
Other common symptoms may include nausea, vomiting, diarrhea, lightheadedness, headache, or fatigue.
There is no cure for dysmenorrhea. Nonsteroidal anti-inflammatory drugs (NSAIDs), the most common treatment for both primary and secondary dysmenorrhea may be effective, however, the drugs can induce some serious side effects, including liver or kidney problems. and hypertension.
If you are currently using conventional medicine for the treatment of dysmenorrhea, please sure you know all the side effects for the preventive measure.
.
In the use of diet therapy for the prevention and treatment of dysmenorrhea, Dr. Dina Abadi Bavil, the lead scientist said, "Given the scores obtained on the lifestyle questionnaire, significant differences were observed between the groups with and without dysmenorrhea in terms of eating behavior (p=0.008), physical activity (p=0.011), stress (p=0.041), and social relationships".
These results clearly suggested that a healthy diet and lifestyle play important roles in the prevention
and treatment of dysmenorrhea
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
On findings of a natural ingredient or whole food for the prevention and treatment of dysmenorrhea in the replacement of conventional medicine without inducing side effects, researchers examine the effects of ginger on primary dysmenorrhea, through searching the database of medical literature online.
Six selected studies were reviewed by 2 authors independently.
Ginger appeared more effective for reducing pain severity than placebo.
Ginger was found as effective as those of mefenamic acid (an NSAID).
The finding point to one conclusion, oral ginger could be an effective treatment for menstrual pain in dysmenorrhea.
Dr. Daily JW, the lead scientists in another search to find the evidence of ginger for treating primary dysmenorrhea launched an investigation by looking into the database of 12 medical libraries.
Seven met specific selection criteria were included in the review.
Four of the RCTs compared the therapeutic efficacy of ginger with placebo during the first 3-4 days of the menstrual cycle and were included in the meta-analysis.
The results of the in-depth differentiation showed that ginger processes a significant effect in reducing the Pain Visual Analogue Scale (PVAS) in subjects having primary dysmenorrhea.
Six RCTs out of 7 exhibited low to moderate of the risk of bias.
These results of the RCTs strongly indicated the suggestive evidence for the effectiveness of 750-2000 mg ginger powder during the first 3-4 days of the menstrual cycle for primary dysmenorrhea.
Taken altogether, ginger may be considered a functional remedy for the prevention and treatment of painful periods with no side effects.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(2) Efficacy of Oral Ginger (Zingiber officinale) for Dysmenorrhea: A Systematic Review and Meta-Analysis by Chen CX1, Barrett B2, Kwekkeboom KL3. (PubMed)
(3) Efficacy of Ginger for Alleviating the Symptoms of Primary Dysmenorrhea: A Systematic Review and Meta-analysis of Randomized Clinical Trials by Daily JW1, Zhang X2, Kim DS2, Park S2. (PubMed)
(4) Comparison of lifestyles of young women with and without primary dysmenorrhea by Dina Abadi Bavil,1 Mahrokh Dolatian,2 Zohreh Mahmoodi,3,4 and Alireza Akbarzadeh Baghban. (PMC)
Wednesday, April 1, 2020
Green Tea GTE and EGCG, The Natural Anti Chronic Fatigue Syndrome Supplements
Scientists may have found a beverage's extract and bioactive compound for the treatment of chronic fatigue syndrome (CFS), some studies suggested.
Chronic fatigue syndrome (CFS) is a medical disorder that cannot be explained by an underlying medical condition, characterized by persistently extreme fatigue that never goes away regardless of treatment.for at least 6 months.
The exact causes of chronic fatigue syndrome are unknown. However, some researchers suggested that the conditions are the results of viral infection and chronic stress syndrome.
The University of South Florida (USF Health) in the article "Chronic fatigue syndrome: The inherited virus can cause cognitive dysfunction and fatigue" wrote, "Medveczky's team discovered that untreated CIHHV-6 patients with CFS showed signs that the HHV-6 virus was actively replicating: determined by the presence of HHV-6 messenger RNA (mRNA), a substance produced only when the virus is active".
In the psychological aspects of chronic fatigue syndrome, Dr. Takakazu Oka at the International University of Health and Welfare wrote, " psychological stress is involved in the CFS onset, exacerbation, and/or relapse, while early life stress acts as a risk factor toward the development of CFS in later life" and "CFS patients may have disrupted stress systems, including HPA axis hypofunction and ANS alterations characterized by sympathetic overactivity and low vagal tone. Individuals with CFS respond to psychological stress".
Some researchers also found that elimination diets, dietary restriction and the addition of nutritional supplements to the habitual diet may have a beneficial effect in reducing fatigue.
The randomized control trials, including pilot studies, compared a form of nutritional supplement with a placebo control suggested, treatment of a combination of nicotinamide adenine dinucleotide hydride (NADH) and coenzyme Q10 (CoQ10) exerts a significant reduction of fatigue after 8 weeks, compared to placebo.
Green tea is a precious drink that processes number of health benefits known to almost everyone in Asia and the Western world.
In the concerns of the oxidative stress in the exhibited CFS, researchers at the Panjab University launched an investigation to examine the protective effect of green tea extract (GTE) and catechin in the mouse model of CFS.
CFS animals used in the study forced swimming test session of 6 minutes every day for 7 days demonstrated a significant increase in immobility time on successive days.
Treatment with GTE (25 or 50 mg/kg, i.p.) and catechin (50 or 100 mg/kg, i.p.) for 7 days reversed the dysfunction of immobility.
Furthermore, the protection of green tea extract was correlated with the lowered levels of lipid peroxidation and restoration of reduced glutathione levels in the brains of fatigued mice.
These results suggested that oxidative stress plays a pivotal role in the pathophysiology of CFS.
Dr. Singal A, the lead scientist said, "GTE and catechin could be used as potential agents in the management of CFS and warrant the inclusion of GTE and catechin in the treatment regimen of CFS patients".
Moreover, in the evaluate the pathogenesis of chronic fatigue syndrome involved increased oxide-nitrosative stress along with the generation of pro-inflammatory cytokines such as TNF-α, in chronic fatigue rats induced by a plunge of a load of 10 ± 2% body weight and forced swim inside a rectangular jar daily for 28 days, researchers found that
* Before the application of EGCG, chronic fatigue rats exhibited significant behavioral alterations along with enhanced oxido-nitrosative stress and serum TNF-α level, compared to the naive group.
* Chronic treatment with EGCG restored all the behavioral and biochemical alterations associated with chronic fatigue syndrome.
Additionally, in the study of chronic fatigue induced in mice by subjecting them to forced swim inside a rectangular jar of specific dimensions for 6 min. daily for 15 days, researchers found that Epigallocatechin gallate (EGCG; 25, 50 and 100 mg/kg, p.o.) administered daily 30 min. before a forced swim session
* Increased oxidative-nitrosative stress and tumor necrosis factor-alpha levels in the brain of mice before green tea administration compared with the naive group.
* These behavioral and biochemical alterations were restored after chronic treatment with EGCG.
Taken altogether, green tea extract (GTE) and its bioactive chemicals EGCG may have the therapeutic effect in reducing the risk and treatment of chronic fatigue syndrome
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea extract and catechin ameliorate chronic fatigue-induced oxidative stress in mice by Singal A1, Kaur S, Tirkey N, Chopra K.(PubMed)
(2) Epigallocatechin gallate ameliorates behavioral and biochemical deficits in rat model of load-induced chronic fatigue syndrome by Sachdeva AK1, Kuhad A, Chopra K.(PubMed)
(3) Protective effect of epigallocatechin gallate in murine water-immersion stress model of chronic fatigue syndrome by Sachdeva AK1, Kuhad A, Tiwari V, Arora V, Chopra K.(PubMed)
(4) Chronic fatigue syndrome: Inherited virus can cause cognitive dysfunction and fatigue Date: July 26, 2013 Source: University of South Florida (USF Health)
(5) Influence of Psychological Stress on Chronic Fatigue Syndrome by Takakazu Oka
Chronic fatigue syndrome (CFS) is a medical disorder that cannot be explained by an underlying medical condition, characterized by persistently extreme fatigue that never goes away regardless of treatment.for at least 6 months.
The exact causes of chronic fatigue syndrome are unknown. However, some researchers suggested that the conditions are the results of viral infection and chronic stress syndrome.
The University of South Florida (USF Health) in the article "Chronic fatigue syndrome: The inherited virus can cause cognitive dysfunction and fatigue" wrote, "Medveczky's team discovered that untreated CIHHV-6 patients with CFS showed signs that the HHV-6 virus was actively replicating: determined by the presence of HHV-6 messenger RNA (mRNA), a substance produced only when the virus is active".
In the psychological aspects of chronic fatigue syndrome, Dr. Takakazu Oka at the International University of Health and Welfare wrote, " psychological stress is involved in the CFS onset, exacerbation, and/or relapse, while early life stress acts as a risk factor toward the development of CFS in later life" and "CFS patients may have disrupted stress systems, including HPA axis hypofunction and ANS alterations characterized by sympathetic overactivity and low vagal tone. Individuals with CFS respond to psychological stress".
Some researchers also found that elimination diets, dietary restriction and the addition of nutritional supplements to the habitual diet may have a beneficial effect in reducing fatigue.
The randomized control trials, including pilot studies, compared a form of nutritional supplement with a placebo control suggested, treatment of a combination of nicotinamide adenine dinucleotide hydride (NADH) and coenzyme Q10 (CoQ10) exerts a significant reduction of fatigue after 8 weeks, compared to placebo.
Green tea is a precious drink that processes number of health benefits known to almost everyone in Asia and the Western world.
In the concerns of the oxidative stress in the exhibited CFS, researchers at the Panjab University launched an investigation to examine the protective effect of green tea extract (GTE) and catechin in the mouse model of CFS.
CFS animals used in the study forced swimming test session of 6 minutes every day for 7 days demonstrated a significant increase in immobility time on successive days.
Treatment with GTE (25 or 50 mg/kg, i.p.) and catechin (50 or 100 mg/kg, i.p.) for 7 days reversed the dysfunction of immobility.
Furthermore, the protection of green tea extract was correlated with the lowered levels of lipid peroxidation and restoration of reduced glutathione levels in the brains of fatigued mice.
These results suggested that oxidative stress plays a pivotal role in the pathophysiology of CFS.
Dr. Singal A, the lead scientist said, "GTE and catechin could be used as potential agents in the management of CFS and warrant the inclusion of GTE and catechin in the treatment regimen of CFS patients".
Moreover, in the evaluate the pathogenesis of chronic fatigue syndrome involved increased oxide-nitrosative stress along with the generation of pro-inflammatory cytokines such as TNF-α, in chronic fatigue rats induced by a plunge of a load of 10 ± 2% body weight and forced swim inside a rectangular jar daily for 28 days, researchers found that
* Before the application of EGCG, chronic fatigue rats exhibited significant behavioral alterations along with enhanced oxido-nitrosative stress and serum TNF-α level, compared to the naive group.
* Chronic treatment with EGCG restored all the behavioral and biochemical alterations associated with chronic fatigue syndrome.
Additionally, in the study of chronic fatigue induced in mice by subjecting them to forced swim inside a rectangular jar of specific dimensions for 6 min. daily for 15 days, researchers found that Epigallocatechin gallate (EGCG; 25, 50 and 100 mg/kg, p.o.) administered daily 30 min. before a forced swim session
* Increased oxidative-nitrosative stress and tumor necrosis factor-alpha levels in the brain of mice before green tea administration compared with the naive group.
* These behavioral and biochemical alterations were restored after chronic treatment with EGCG.
Taken altogether, green tea extract (GTE) and its bioactive chemicals EGCG may have the therapeutic effect in reducing the risk and treatment of chronic fatigue syndrome
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea extract and catechin ameliorate chronic fatigue-induced oxidative stress in mice by Singal A1, Kaur S, Tirkey N, Chopra K.(PubMed)
(2) Epigallocatechin gallate ameliorates behavioral and biochemical deficits in rat model of load-induced chronic fatigue syndrome by Sachdeva AK1, Kuhad A, Chopra K.(PubMed)
(3) Protective effect of epigallocatechin gallate in murine water-immersion stress model of chronic fatigue syndrome by Sachdeva AK1, Kuhad A, Tiwari V, Arora V, Chopra K.(PubMed)
(4) Chronic fatigue syndrome: Inherited virus can cause cognitive dysfunction and fatigue Date: July 26, 2013 Source: University of South Florida (USF Health)
(5) Influence of Psychological Stress on Chronic Fatigue Syndrome by Takakazu Oka
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