Asthma in vitamin B12 points of view

The widespread of incidence of asthma over large 20 years in South East Asian population, specially in children and aging group has caused some concerns to the government and scientific community. It may be due to over intake in artificial ingredients, polluted environment as well as intake foods  triggering the inflammatory allergens.

Vitamin B12, also known as cobalamin, a water-soluble vitamin, found abundantly in a variety of foods, such as fish, shellfish, meat, eggs, dairy products, etc. plays an important role in regulating the functions of nervous system and formation of blood.

The conflict results
Epidemiological studies, linking vitamin B12 in reduced risk and treatment of asthma have produced inconclusive results. Some researchers through searching the data base of asthma studies suggested that insufficient evidence exists to recommend supplementation with any vitamin or nutrient acting as a methyl donor to prevent or treat asthma(1). Other found the conflict results in the associated risk of the disease(2). Other insisted no correlation between vitamin B12 intake and risk of asthma or atopy(3). Intake of vitamin B12 during pregnancy may effect the incidence of  asthma and asthmatic symptoms of offspring, but according to the Osaka Maternal and Child Health study, there was no correlation  between maternal consumption of folate, vitamin B(12) , vitamin B(6) , and vitamin B(2) during pregnancy and the risk of wheeze or eczema in the offspring(4).
Because of limitation of quantity of the studies in the data base to determine the risk of dietary intake of vitamin B12' effect on asthmatics. We recommend the use of vitamin B12 with care in pregnancy. As always, over doses of the vitamin B12 may induce symptoms of toxicity, including headache, giddiness and abnormal heart functioning, etc., please make sure to follow the guideline of the Institute of Medicine of the National Academies.


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References
(1) Diet and asthma: vitamins and methyl donors by Han YY¹, Blatter J¹, Brehm JM¹, Forno E¹, Litonjua AA², Celedón JC³.(PubMed)
(2) Asthma, allergy, and responses to methyl donor supplements and nutrients by Sharma S¹, Litonjua A².(PubMed)
(3) Atopy, asthma, and lung function in relation to folate and vitamin B(12) in adults by Thuesen BH¹, Husemoen LL, Ovesen L, Jørgensen T, Fenger M, Gilderson G, Linneberg A.(PubMed)
(4) Maternal B vitamin intake during pregnancy and wheeze and eczema in Japanese infants aged 16-24 months: the Osaka Maternal and Child Health Study by Miyake Y¹, Sasaki S, Tanaka K, Hirota Y.(PubMed)