Ovarian Cancer in Vitamin B6 Points of View

Ovarian cancer is defined as a condition of  abnormal ovarian cells growth of ovaries,  It is one of most common cancer in US, according to the statistics adapted from the American Cancer Society's publication, Cancer Facts & Figures 2010, an estimated 21,880 women in the United States will be diagnosed with ovarian cancer and 13,850 deaths.

Vitamin B6, also known as pyridoxine, is a water soluble vitamin found abundantly in green peas, yams, broccoli, asparagus and turnip greens, Peanuts, sunflower seeds, cashews and hazelnuts, meat, fish etc., with functions of amino acid, carbohydrate  metabolism, brain health, and liver detoxification, etc.

Epidemiological studies, linking vitamin B6 in reduced risk of ovarian cancer have been inconclusive(a)(b)(c)(d).

Dietary intakes of vegetable, fruit, fiber, folate, and B vitamins have been associated with reduced breast and/or ovarian cancer risk. According to the California State University, women with family history of breast and/or ovarian cancer, FHBOC should be encouraged to meet dietary guidelines for a potentially reduced breast and/or ovarian cancer risk(1). Other study showed a positive effect of the combination therapy of acupuncture of PC6 point injection plus vitamin B6, in alleviation of  the symptoms of chemotherapy in patients with ovarian cancer, according to the First Affiliated Hospital of Harbin Medical University in the study of a total of 142 patients undergoing a highly emetogenic chemotherapy regimen between March 1, 2006, and June 30, 2008(2). But in a total of total of 248 analyzable patients with Stages III-IV ovarian epithelial cancer, researchers suggested vitamin B6 should not be used in conjunction with  one of four cisplatin (DDP)-hexamethylmelamine (HMM) regimens, although pyridoxine administration significantly reduced neurotoxicity, because of its adverse effect on response duration(3).

Taken altogether, administration of vitamin B6 in reduced risk of ovarian cancer may be still controversial but dietary intakes of vegetable, fruit, fiber, folate, and B vitamins may be necessary to prevent nutrient deficiency cause of breast and/or ovarian cancer risk. Over doses may induced the symptoms of difficulty coordinating movement, numbness, sensory changes, etc., please make sure you follow the guideline of the Institute of Medicine of the National Academies.

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References
(a) Folate, vitamin B(6) , vitamin B(12) , methionine and alcohol intake in relation to ovarian cancer risk by Harris HR¹, Cramer DW, Vitonis AF, DePari M, Terry KL(PubMed)
(b) Pyridoxine to protect from oxaliplatin-induced neurotoxicity without compromising antitumour effect by Garg MB¹, Ackland SP.(PubMed)
(c) Relationship between dietary and supplemental intake of folate, methionine, vitamin B6 and folate receptor alpha expression in ovarian tumors by Kotsopoulos J¹, Hecht JL, Marotti JD, Kelemen LE, Tworoger SS.(PubMed)
(d) Intake of folate and related nutrients in relation to risk of epithelial ovarian cancer by Tworoger SS¹, Hecht JL, Giovannucci E, Hankinson SE.(PubMed)
(1)Diet and predictors of dietary intakes in women with family history of breast and/or ovarian cancer by McEligot AJ¹, Mouttapa M, Ziogas A, Anton-Culver H.(PubMed)
(2) Vitamin B6 points PC6 injection during acupuncture can relieve nausea and vomiting in patients with ovarian cancer by You Q¹, Yu H, Wu D, Zhang Y, Zheng J, Peng C(PubMed)
(3) Hexamethylmelamine and low or moderate dose cisplatin with or without pyridoxine for treatment of advanced ovarian carcinoma: a study of the Eastern Cooperative Oncology Group by Wiernik PH¹, Yeap B, Vogl SE, Kaplan BH, Comis RL, Falkson G, Davis TE, Fazzini E, Cheuvart B, Horton J.(PubMed)