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Friday, December 16, 2016

Hormone(Catecholamines) Epinephrine: Propranolol administration epinephrine-stimulated SSRBC adhesion in Sickle red blood cells (SSRBCs) patients

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.                     

                      Catecholamines

Catecholamines, derived from the amino acid tyrosine, produced by the adrenal glands, which are found on top of the kidneys. are epinephrine (adrenaline), norepinephrine (noradrenaline) and dopamine. The hormone are released into the blood during times of physical or emotional stress.


     Propranolol administration epinephrine-stimulated SSRBC adhesion in Sickle red blood cells (SSRBCs)  patients

Sickle red blood cells (SSRBCs) adhere to both endothelial cells (ECs) and the extracellular matrix. In the study to investigate whether systemically administered propranolol inhibits SSRBC adhesion and to document the safety of propranolol in SCD, indicated that Propranolol administration significantly reduced epinephrine-stimulated SSRBC adhesion in a dose dependent manner (p = 0.03), with maximum inhibition achieved at 40 mg. Adverse events were not severe, did not show dose dependence, and were likely unrelated to drug. No significant heart rate changes occurred. These results imply that β-blockers may have a role as antiadhesive therapy for SCD(3).

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Sources
(3) http://www.ncbi.nlm.nih.gov/pubmed/23253664

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