Sunday, May 28, 2017

Thyroid hormone: Radioiodine treatment and oxidative stress in thyroidectomised patients

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.                     

                                 Thyroid hormone

Thyroid hormone (triiodothyronine (T3) and thyroxine (T4)), produced by the thyroid gland, plays an important role in regulation of metabolism, including directly boosts energy metabolism and triggers rapid protein synthesis and regulates mitochondrial gene transcription, etc. Iodine is necessary for the production of T3and T4, deficiency of Iodine can lead to enlarge thyroid grand and goitre.

     Thyroid hormone: Radioiodine treatment and oxidative stress in thyroidectomised patients

Post-operative radioiodine treatment of differentiated thyroid cancer occupies a well determined place in the treatment policy of this disease. In the study to measure erythrocyte malondialdehyde (MDA) levels, as a marker of lipid peroxidation, erythrocyte reduced glutathione (GSH) levels and activities of GSH-Peroxidase and GSH-Reductase as antioxidants, showed that erythrocyte MDA levels were significantly higher, and erythrocyte GSH levels and activities of GSH-related enzymes were significantly lower in thyroidectomised patients after surgery than in healthy controls. Additionally, according to their thyroid hormone levels the patients had hypothyroidism at this time. In patients 2 days after radioiodine treatment both MDA and GSH levels and GSH-related enzyme activities were significantly increased when compared to their own initial levels(18).

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