Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in nature herbal medicine or food, long term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" induding weaken immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
According to the Harvard Medical School, epigallocatechin-3-gallate (EGCG) isolated from green tea expressed a strong effect on T cell functions, including T cell activation, proliferation, differentiation, and production of cytokines.
Injection of the phytochemical in animal model showed significant effects in regulated T cell dysfunction in expression of autoimmune inflammatory diseases as well as ameliorated T cell-mediated autoimmune diseases.
Furthermore, in naïve CD4(+) T cells proliferate and differentiate into different effector subsets, green tea EGCG inhibited the pro inflammatory Th1 and Th17 cells, subsets of Th cells responsible for inducing autoimmunity, thus improving symptoms and reducing the pathology of autoimmune diseases.
Additionally, Dr. Wu D, the lead author said, "(The) protective effect EGCG is associated with the suppressed proliferation of autoreactive T cells, in reduced production of pro-inflammatory cytokines of Th1 and Th17, and increased T cell regulation populations in lymphoid tissues and central nervous system".
Further evaluation of green tea EGCG effect in regulated CD4(+) T helper (Th) subsets Th1, Th9, and Th17 cells conducted by the Tufts University, potulated that the phytochemical impeded Th1, Th9, and Th17 differentiation in exhibited inflammation by prevented IL-6(the pro inflammatory cytokine)-induced suppression of Treg development.
More importantly, in experimental autoimmune encephalomyelitis (EAE) rats, EGCG improved function of CD4(+) T cell through modulated the expression of IL-6 induced cytokin(gp130) in response to auto immune function and cellular response.
Taking together, green tea process a strong immunomodulating effect in reduced risk and treatment of auto inflammatory and immune disease, but long term and large amount intake should be taken with care to prevent toxicity.
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Author: Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
(2) Green tea EGCG, T cells, and T cell-mediated autoimmune diseases by Wu D1, Wang J, Pae M, Meydani SN.(PubMed)
(3) Green tea epigallocatechin-3-gallate modulates differentiation of naïve CD4⁺ T cells into specific lineage effector cells by Wang J1, Pae M, Meydani SN, Wu D.(PubMed)