Green Tea: Health Benefits of Sencha Tea - Congitive Activities

Sencha is a type of decocted Japanese green tea, most popular tea in Japan, made from the dried tea leaves without grinding the tea leaves. It volatile compounds could be used as markers for the overall quality evaluation of all green tea.

Health Benefits of Sencha Tea - Congitive Activities
a. In the evaluation of the effect of teapolyphenol (TP) on cognitive and anti-cholinesterase activity of the study of "Effectsof green tea polyphenol on cognitive and acetylcholinesterase activities" by Kim HK, Kim M, Kim S, Kim M, Chung JH.[11a], researchers found that TP exhibited a dramatic inhibitory effect on acetylcholinesterase activity. This finding suggests that TP might be useful in the treatment of Alzheimer's disease.

b. In rhe investigation of green tea catechin, induces HO-1 by ARE/Nrf2 pathway in hippocampal neurons in protection of neurons against different models of oxidative damages of the study of "Modulation of Nrf2/ARE pathway by food polyphenols: a nutritional neuroprotective strategy for cognitive and neurodegenerative disorders" by Scapagnini G, Vasto S, Abraham NG, Caruso C, Zella D, Fabio G.[11b], researchers found that caffeic acid phenethyl ester and ethyl ferulate, are also able to protect neurons via HO-1 induction. These studies identify a novel class of compounds that could be used for therapeutic purposes as preventive agents against cognitive decline.

c. In the assessment of the combination of green tea extract and l-theanine (LGNC-07) in congitive effects of the study of "A combination of green tea extract and l-theanine improves memory and attention in subjects with mild cognitiveimpairment: a double-blind placebo-controlled study" by Park SK, Jung IC, Lee WK, Lee YS, Park HK, Go HJ, Kim K, Lim NK, Hong JT, Ly SY, Rho SS.[11c], researchers wrote that brain theta waves, an indicator of cognitivealertness, were increased significantly in the temporal, frontal, parietal, and occipital areas after 3 hours in the eye-open and reading states. Therefore, this study suggests that LGNC-07 has potential as an intervention for cognitiveimprovement.

d. In the evaluation of l-Theanine and its effects of Amyloid beta (Abeta)-induced neurotoxicity which is a major pathological mechanism of Alzheimer disease (AD) of the study of "l-Theanine, an amino acid in green tea, attenuates beta-amyloid-induced cognitive dysfunction and neurotoxicity: reduction in oxidative damage and inactivation of ERK/p38 kinase and NF-kappaB pathways" by Kim TI, Lee YK, Park SG, Choi IS, Ban JO, Park HK, Nam SY, Yun YW, Han SB, Oh KW, Hong JT.[11d], researchers suggested that the positive effects of l-theanine on memory may be mediated by suppression of ERK/p38 and NF-kappaB as well as the reduction of macromolecular oxidative damage. Thus, l-theanine may be useful in the prevention and treatment of AD.

e. In the determination of Green tea (-)-epigallocatechin-3-gallate(EGCG) and its effects of cognitive dysfunction of the study of "Greentea (-)-epigallocatechin-3-gallate inhibits beta-amyloid-induced cognitivedysfunction through modification of secretase activity via inhibition of ERK and NF-kappaB pathways in mice" by Lee JW, Lee YK, Ban JO, Ha TY, Yun YP, Han SB, Oh KW, Hong JT.[11e], researchers found that EGCG enhanced memory function and brain alpha-secretase activity but reduced brain beta- and gamma-secretase activities as well as Abeta levels. Moreover, EGCG inhibited the fibrillization of Abeta in vitro with a half maximal inhibitory concentration of 7.5 mg/L


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Sources
[1] http://www.ncbi.nlm.nih.gov/pubmed/21664180
[11a] http://www.ncbi.nlm.nih.gov/pubmed/15388975
[11b] http://www.ncbi.nlm.nih.gov/pubmed/21499987
[11c] http://www.ncbi.nlm.nih.gov/pubmed/21303262
[11d] http://www.ncbi.nlm.nih.gov/pubmed/19766184
[11e] http://www.ncbi.nlm.nih.gov/pubmed/19656855