Health Benefits of Sencha Tea - Human immunodeficiency virus (HIV)
a. In the determination of Green Tea-EGCG effects in HIV-1of the study of 'Green Tea-EGCG reduces GFAP associated neuronal loss in HIV-1 Tat transgenic mice" by Rrapo E, Zhu Y, Tian J, Hou H, Smith A, Fernandez F, Tan J, Giunta B.[15a], researchers found that that EGCG (300mg/kg/day) dramatically reduced astrogliosis as demonstrated by GFAP expression. This was accompanied by a mild reduction in activated microglia by Iba-1 staining and significant reduction in neuronal loss through apoptosis as demonstrated by MAP2 staining and Western blot analysis respectively.
b. in examination of the effects of EGCG and HIV-1 proteins gp120 of the study of "EGCG mitigates neurotoxicity mediated by HIV-1 proteins gp120 and Tat in the presence of IFN-gamma: role of JAK/STAT1 signaling and implications for HIV-associated dementia" by Giunta B, Obregon D, Hou H, Zeng J, Sun N, Nikolic V, Ehrhart J, Shytle D, Fernandez F, Tan J.[15b], researchers found that EGCG treatment of primary neurons from normal mice reduced IFN-gamma-enhanced neurotoxicity of gp120 and Tat by inhibiting JAK/STAT1 pathway activation and found to mitigate the neurotoxic properties of HIV-1 proteins in the presence of IFN-gamma in vivo.
c. In the investigation of green tea polyphenol epigallocatechin-3-gallate counteractsSources and HIV infection of the study of "The main green tea polyphenol epigallocatechin-3-gallate counteracts semen-mediated enhancement of HIV infection" by Hauber I, Hohenberg H, Holstermann B, Hunstein W, Hauber J., researchers found that EGCG appears to be a promising supplement to antiretroviral microbicides to reduce sexual transmission of HIV-1.
d. In the assessment of green tea catechin, epigallocatechin gallate (EGCG) and HIV-1 glycoprotein 120 to the CD4 molecule on T cells of the study of "Preclinical development of the green tea catechin, epigallocatechin gallate, as an HIV-1 therapy' by Nance CL, Siwak EB[15d], Shearer WT. researchers found that by preventing the attachment of HIV-1-glycoprotein 120 to the CD4 molecule, EGCG inhibits HIV-1 infectivity. Because this inhibition can be achieved at physiologic concentrations, the natural anti-HIV agent EGCG is a candidate as an alternative therapy in HIV-1 therapy.
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[15b] http://www.mendeley.com/research/egcg-mitigates-neurotoxicity-mediated-hiv1-proteins-gp120-tat-presence-ifngamma-role-jakstat1-signaling-implications-hivassociated-dementia/[15c] http://www.pnas.org/content/early/2009/05/15/0811827106[15d] http://www.ncbi.nlm.nih.gov/pubmed/19203663
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