Green tea: Health Benefits of Sencha Tea - Human immunodeficiency virus (HIV)

Sencha is a type of decocted Japanese green tea, most popular tea in Japan, made from the dried tea leaves without grinding the tea leaves. It volatile compounds could be used as markers for the overall quality evaluation of all green tea.

Health Benefits of Sencha Tea -  Human immunodeficiency virus (HIV)
a. In the determination of Green Tea-EGCG effects in HIV-1of the study of 'Green Tea-EGCG reduces GFAP associated neuronal loss in HIV-1 Tat transgenic mice" by Rrapo E, Zhu Y, Tian J, Hou H, Smith A, Fernandez F, Tan J, Giunta B.[15a], researchers found that that EGCG (300mg/kg/day) dramatically reduced astrogliosis as demonstrated by GFAP expression. This was accompanied by a mild reduction in activated microglia by Iba-1 staining and significant reduction in neuronal loss through apoptosis as demonstrated by MAP2 staining and Western blot analysis respectively.

b. in examination of the effects of EGCG and HIV-1 proteins gp120 of the study of "EGCG mitigates neurotoxicity mediated by HIV-1 proteins gp120 and Tat in the presence of IFN-gamma: role of JAK/STAT1 signaling and implications for HIV-associated dementia" by Giunta B, Obregon D, Hou H, Zeng J, Sun N, Nikolic V, Ehrhart J, Shytle D, Fernandez F, Tan J.[15b], researchers found that EGCG treatment of primary neurons from normal mice reduced IFN-gamma-enhanced neurotoxicity of gp120 and Tat by inhibiting JAK/STAT1 pathway activation and found to mitigate the neurotoxic properties of HIV-1 proteins in the presence of IFN-gamma in vivo.

c. In the investigation of green tea polyphenol epigallocatechin-3-gallate counteractsSources and HIV infection of the study of "The main green tea polyphenol epigallocatechin-3-gallate counteracts semen-mediated enhancement of HIV infection" by Hauber I, Hohenberg H, Holstermann B, Hunstein W, Hauber J., researchers found that EGCG appears to be a promising supplement to antiretroviral microbicides to reduce sexual transmission of HIV-1.

d. In the assessment of green tea catechin, epigallocatechin gallate (EGCG) and HIV-1 glycoprotein 120 to the CD4 molecule on T cells of the study of "Preclinical development of the green tea catechin, epigallocatechin gallate, as an HIV-1 therapy' by Nance CL, Siwak EB[15d], Shearer WT. researchers found that by preventing the attachment of HIV-1-glycoprotein 120 to the CD4 molecule, EGCG inhibits HIV-1 infectivity. Because this inhibition can be achieved at physiologic concentrations, the natural anti-HIV agent EGCG is a candidate as an alternative therapy in HIV-1 therapy.

e. Etc.
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Sources
[1] http://www.ncbi.nlm.nih.gov/pubmed/21664180
[15a] http://www.ncbi.nlm.nih.gov/pubmed/19966940
[15b] http://www.mendeley.com/research/egcg-mitigates-neurotoxicity-mediated-hiv1-proteins-gp120-tat-presence-ifngamma-role-jakstat1-signaling-implications-hivassociated-dementia/[15c] http://www.pnas.org/content/early/2009/05/15/0811827106[15d] http://www.ncbi.nlm.nih.gov/pubmed/19203663

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