Green tea mixed in tobacco can significantly improve chronic cigarette smokers to quit smoke naturally, some scientists suggested.
Smoking has a history in many cultures dated back as early as 5000 BC. Europeans who arrived to America in the 16th century have quickly transformed the land to cultivated these plants for commercial profits and encourage consumption.
Our ancestors used tobacco smoke as a healing practice and enhanced pleasure. However, according to the study of the University of Manchester(4), our ancestor also use tobacco for healing purposes.
* Tobacco medical use that is administered externally includes bites of poisonous reptiles and insects; hysteria; pain, neuralgia; laryngeal spasm; gout; growth of hair; tetanus; ringworm; rodent ulcer; ulcers; wounds; a respiratory stimulant.
* Tobacco medical use that is administered by rectum includes constipation; hemorrhoidal bleeding
* Tobacco medical use that is administered internally, includes strangulated hernia (smoke by mouth); malaria or intermittent fever; dislodging obstructive material from the esophagus by inducing vomiting. And
* Tobacco medical use by inhalation includes nasal polyps.
Sadly, the medical use of tobacco now is considered nonexistence. At of today statistic, tobacco smoking including cigarettes is causing over 3 million deaths a year worldwide, and if current smoking trends continue the annual mortality will exceed 10 million by around 2030, Dr. Anne Charlton, the author of the study suggested(4).
Continuously, the doctor said, " Tobacco leaves and the smoke generated when they are burned contain over 4 thousand chemicals, the best known of which is nicotine, first isolated from tobacco leaves in 1828 by Posselt and Reimann. It is the nicotine that causes smokers to become addicted to tobacco, and the chemical itself is lethal in small doses".
According to a statistic from the CDC, more than 4 out of 10 (45.5%) of all high school students who smoke tried to stop smoking in the past 12 months. Since 2002, the number of former smokers has been greater than the number of current smokers in the US(5).
Truly, a high percentage of smokers try to quit, however, smokers who successfully quit smoke are quite low because nicotine is highly addictive.
Green tea contains more amount of antioxidants than any drinks or foods with the same volume, and is the leaves of Camellia sinensis, undergone minimal oxidation during processing, originated from China.
In the study to test the effects of tea filter in promoted tobacco cessation in volunteers smokers, researchers found that smoking tobacco with tea filter successfully decreased cigarette consumption of participants by 56.5%, and 31.7% of them stopped smoking(1).
Further analysis of tea filter effects suggested the results may be attributed to the tea filter's bioactive chemical theanine in exerting anti-tobacco and nicotine addiction activities.
Dr. Yan J, the lead author said, "This work identified a new method and material, tea filter and theanine, which inhibit tobacco and nicotine addiction and provide an effective strategy for treating tobacco addiction"(1).
Additionally, in the review of clinical studies evaluating herbals use for smoking cessation from databases from its inception to October 2012. Studies are restricted to only English or Thai, researchers indicated that out a total of 7 studies met inclusion criteria; 6 studies were a randomized trial (RCT) evaluating a variety of herbals.
According to the smoking cessation measured with various methods including the number of cigarettes per day, abstinence rate, expired CO level, and urine cotinine level at the 3 and 6 months follow up, application of mix herbal tea showed a statistically significant effect in reduced numbers of cigarettes smoked per day, nicotine craving, and total withdrawal scale but not urinary cotinine excretion(2).
However, Dr. Kitikannakorn N, the lead scientists, after taking into account of other co and confounders said, "Evidence supporting the role of complementary medicines as an anti-smoking is limited. Further research in this field would benefit from the standardization of herbals products to implement on standard interventions and outcome measurement for smoking cessation".
Interestingly, according to the study by the Science China Life Sciences to test the effect of green tea lace in a cigarette in increased smoke cessation probability, researchers found that custom-designed cigarettes laced with green tea components exerted a significant effect in reduced smoking cravings.
After 2 months of smoking this unique cigarette, researchers found that smoker reduced their smoking intake by 52% compared to control.
These results be of successful may be attributed to green tea bioactive amino acid L-Theanine, uniquely found in green tea that processes clinical proven anti-stress effects and acts as a relaxing agent(3).
Prince Philip, a lecturer in the Community Oncology Division of the Malabar Cancer Centre, said, "The study conducted in China shows that green tea may be an alternative to quit this addictive habit".
Taking all together, green tea used cigarette lace may be considered as a secondary and therapeutic treatment in increased the change of quit smoking. However, how many people have the money to order these types of customer designed cigarette?. Probably, we may stick to cold turkey quitting?, nicotine patch?
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The cessation and detoxification effect of tea filters on cigarette smoke by Yan J1, Di X, Liu C, Zhang H, Huang X, Zhang J, Zhao Y, Zhang L, Chang Y, Liang Y, Tao R, Zhao B(PubMed)
(2) An overview of the evidences of herbals for smoking cessation by Kitikannakorn N1, Chaiyakunapruk N, Nimpitakpong P, Dilokthornsakul P, Meepoo E, Kerdpeng W.(PubMed)
(3) A revolutionary approach for the cessation of smoking by Liu J(PubMed)
(4) Medicinal uses of tobacco in history by Anne Charlton, BA PhD(PMC)
(5) Quitting Smoking by CDC
Monday, September 30, 2019
Phytochemical Alliin Inhibits Parameters Involved in the Onset of Metabolic Syndrome
Metabolic syndrome is a cluster of conditions including obesity, hypertension, hyperglycemia, hypertriglycemia, hyperlipidemia associated with the risk of cardiovascular disease and diabetes.
In other words, if you have 3 of conditions of obesity, high blood pressure, high triglycerides, elevated blood sugar, and low HDL cholesterol, you are at the increased risk of CVD and diabetes.
Epidemiological studies suggested people who are overweight and obesity and physical inactivity and have a condition of insulin resistance are most likely to have metabolic syndrome developing.
In the unpreventable risk factors such as aging, ethnicity, and a dietary carbohydrate, with a lower intake of crude fiber are also found in the people with the condition.
According to the statistics, among US adults aged 18 years or older, the prevalence of metabolic syndrome rose by more than 35%. From 1988–1994 to 2007–2012, the condition increased from 25.3% to 34.2%.
Out of many risk factors associated with the onset of metabolic syndrome, some researchers suggested the promotion of the Western diet over the past few decades may be the major culprit in inducing the rise of the metabolic syndrome, globally.
Dr. Mohammad G. Saklayen in the investigation of the global epidemic of the metabolic syndrome said, "Though it started in the Western world, with the spread of the Western lifestyle across the globe, it has become now a truly global problem. The prevalence of the metabolic syndrome is often more in the urban population of some developing countries than in its Western counterparts.
And, " The two basic forces spreading this malady are the increase in consumption of high calorie-low fiber-fast food and the decrease in physical activity due to mechanized transportations and sedentary form of leisure time activities".
The results strongly suggested if you are the Western diet follower, your risk of metabolic syndrome increase many folds compared to those of traditional diet.
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
On finding a natural ingredient with anti-metabolic syndrome activity, researchers examined the synthetic form of S-ally-mercapto captopril (CPSSA), a new stable synthetic compound produced by composition of allicin and captopril.
On fructose-induced metabolic syndrome rat model, alliin at 8 mg/kg-day exerted a significant effect by inhibiting the expression of metabolic parameters such as insulin, triglycerides, and homocysteine concentrations with a lesser effect of SBP
Compared to alliin, Captopril (50mg/(kg day)) only improved blood pressure and homocysteine.
Compared to a low dose of CPSSA (5mg/(kg day)) that lowered SBP but did not improve any other measured parameter, a higher dose (50mg/(kg day)) showed a significantly decreased blood pressure, triglycerides, and homocysteine concentrations.
The results strongly suggested that CPSSA, the combination of alliin and captopril may be used for the reducing risk of metabolic syndrome.
In the examination of treatment strategies for MetS include pharmacologic and non-pharmacologic options, associated with the use of nutraceuticals, most of which have plant origins (phytochemicals), accompanied by lifestyle improvement, researchers found that alliin from garlic with an adequate dose should improve a number of the MetS components.
Taken altogether, alliin used alone or combined with conventional medicine may be considered supplements for prevention and treatment of metabolic syndrome, pending to the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The effects of S-allylmercaptocaptopril, the synthetic product of allicin and captopril, on cardiovascular risk factors associated with the metabolic syndrome by Oron-Herman M1, Rosenthal T, Mirelman D, Miron T, Rabinkov A, Wilchek M, Sela BA. (PubMed)
(2) Role of phytochemicals in the management of metabolic syndrome by Cicero AF1, Colletti A. (PubMed)
(3) The Global Epidemic of the Metabolic Syndrome by Mohammad G. Saklayen. (PMC)
In other words, if you have 3 of conditions of obesity, high blood pressure, high triglycerides, elevated blood sugar, and low HDL cholesterol, you are at the increased risk of CVD and diabetes.
Epidemiological studies suggested people who are overweight and obesity and physical inactivity and have a condition of insulin resistance are most likely to have metabolic syndrome developing.
In the unpreventable risk factors such as aging, ethnicity, and a dietary carbohydrate, with a lower intake of crude fiber are also found in the people with the condition.
According to the statistics, among US adults aged 18 years or older, the prevalence of metabolic syndrome rose by more than 35%. From 1988–1994 to 2007–2012, the condition increased from 25.3% to 34.2%.
Out of many risk factors associated with the onset of metabolic syndrome, some researchers suggested the promotion of the Western diet over the past few decades may be the major culprit in inducing the rise of the metabolic syndrome, globally.
Dr. Mohammad G. Saklayen in the investigation of the global epidemic of the metabolic syndrome said, "Though it started in the Western world, with the spread of the Western lifestyle across the globe, it has become now a truly global problem. The prevalence of the metabolic syndrome is often more in the urban population of some developing countries than in its Western counterparts.
And, " The two basic forces spreading this malady are the increase in consumption of high calorie-low fiber-fast food and the decrease in physical activity due to mechanized transportations and sedentary form of leisure time activities".
The results strongly suggested if you are the Western diet follower, your risk of metabolic syndrome increase many folds compared to those of traditional diet.
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
On finding a natural ingredient with anti-metabolic syndrome activity, researchers examined the synthetic form of S-ally-mercapto captopril (CPSSA), a new stable synthetic compound produced by composition of allicin and captopril.
On fructose-induced metabolic syndrome rat model, alliin at 8 mg/kg-day exerted a significant effect by inhibiting the expression of metabolic parameters such as insulin, triglycerides, and homocysteine concentrations with a lesser effect of SBP
Compared to alliin, Captopril (50mg/(kg day)) only improved blood pressure and homocysteine.
Compared to a low dose of CPSSA (5mg/(kg day)) that lowered SBP but did not improve any other measured parameter, a higher dose (50mg/(kg day)) showed a significantly decreased blood pressure, triglycerides, and homocysteine concentrations.
The results strongly suggested that CPSSA, the combination of alliin and captopril may be used for the reducing risk of metabolic syndrome.
In the examination of treatment strategies for MetS include pharmacologic and non-pharmacologic options, associated with the use of nutraceuticals, most of which have plant origins (phytochemicals), accompanied by lifestyle improvement, researchers found that alliin from garlic with an adequate dose should improve a number of the MetS components.
Taken altogether, alliin used alone or combined with conventional medicine may be considered supplements for prevention and treatment of metabolic syndrome, pending to the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The effects of S-allylmercaptocaptopril, the synthetic product of allicin and captopril, on cardiovascular risk factors associated with the metabolic syndrome by Oron-Herman M1, Rosenthal T, Mirelman D, Miron T, Rabinkov A, Wilchek M, Sela BA. (PubMed)
(2) Role of phytochemicals in the management of metabolic syndrome by Cicero AF1, Colletti A. (PubMed)
(3) The Global Epidemic of the Metabolic Syndrome by Mohammad G. Saklayen. (PMC)
Sunday, September 29, 2019
Herbal Ashwagandha Improved Muscle Mass and Strength In Exercise
The Muscle is a soft tissue in the body containing protein filaments of actin and myosin that slide past one another, with a function to produce force and motion.
In other words, muscle contraction and expansion that changes both the length and the shape allow us to move and lift.
Muscle mass is the calculation of the weight of the muscles in the body in kilograms or pounds. However, other factors may also interfere with the above calculation including height, ethnicity, and fitness level.
Increased muscle mass is associated with lower fat accumulation and the ability to burn calories/energy.
Some researchers suggested, by boosting your muscle mass, you will also improve your health, including* Boosts your metabolism. Dr. Alexandra C. McPherron, the lead scientist said, "increasing skeletal muscle mass by inhibiting signaling of myostatin, a transforming growth factor β (TGFβ) family member that negatively regulates muscle growth, prevents the development of diabetes in a mouse model of lipodystrophy. Muscle-specific myostatin inhibition also prevented hyperphagia suggesting muscle may regulate food intake".
In other words, increasing muscle mass improve your body metabolism.
* Improves Bone Mass. Dr. Colletti LAand colleagues said, "additional evidence that muscle-building exercise is associated with increases in BMD at weight-bearing sites but not at on weight-bearing sites".
* Reduces fat accumulation. Dr. Silva TR, the lead scientist wrote, "Skeletal muscle mass index (SMI) was positively correlated with physical activity (r = 0.205, P = 0.038) and protein intake (r = 0.334, P = 0.001), and negatively correlated with waist circumference (r = -0.505, P < 0.001) and %body fat (r = 0.808, P < 0.001)".
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent anti-aging compound, researchers examined the effects of ashwagandha root extract on muscle mass and strength in healthy young men engaged in resistance training.
The randomized, prospective, double-blind, placebo-controlled clinical study included 57 young male subjects (18-50 years old) with little experience in resistance training randomized into treatment received 300 mg of ashwagandha root extract twice daily, (29 subjects) and placebo, consumed starch placebos (28 subjects) groups.
Besides baseline measurements, both groups also underwent resistance training for 8 weeks with measurements repeated at the end of week 8.
Based on the results of measurement of the participants in both groups, compared to placebo, the treatment group showed significantly greater increases i
* In muscle strength on the bench-press exercise (Placebo: 26.4 kg vs. Ashwagandha: 46.0 kg)
* In the leg-extension exercise (Placebo: 9.8 kg) vs. Ashwagandha: 14.5 kg)
* In muscle size increase at the arms (Placebo: 5.3 cm(2) vs. Ashwagandha: 8.6 cm(2))
* In chest (Placebo: 1.4 cm vs. Ashwagandha: 3.3 cm).
Furthermore, ashwagandha treated group also had a significantly greater reduction of exercise-induced muscle damage.
Moreover, Ashwagandha treated group also showed a significantly greater increase in testosterone level (Placebo: 18.0 ng/dL Ashwagandha: 96.2 ng/dL)
More importantly, there was a significantly greater decrease in body fat percentage in treament group compared to placebo (Placebo: 1.5% vs. Ashwagandha: 3.5%).
Based on the finding, researchers wrote, "ashwagandha supplementation is associated with significant increases in muscle mass and strength and suggests that ashwagandha supplementation may be useful in conjunction with a resistance training program".
Taken altogether, Ashwagandha may be used as a supplement for the improvement of muscle mass and strength in the resistance training program, pending to the results from the large sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial by Wankhede S1, Langade D2, Joshi K3, Sinha SR4, Bhattacharyya S. (PubMed)
(2) Increasing muscle mass to improve metabolism by Alexandra C. McPherron, Tingqing Guo, Nichole D. Bond, and Oksana Gavrilova. (PMC)
(3) The effects of muscle-building exercise on bone mineral density of the radius, spine, and hip in young men by Colletti LA1, Edwards J, Gordon L, Shary J, Bell NH. (PubMed)
(4) Skeletal muscle mass is associated with higher dietary protein intake and lower body fat in postmenopausal women: a cross-sectional study by Silva TR1, Spritzer PM. (PubMed)
In other words, muscle contraction and expansion that changes both the length and the shape allow us to move and lift.
Muscle mass is the calculation of the weight of the muscles in the body in kilograms or pounds. However, other factors may also interfere with the above calculation including height, ethnicity, and fitness level.
Increased muscle mass is associated with lower fat accumulation and the ability to burn calories/energy.
Some researchers suggested, by boosting your muscle mass, you will also improve your health, including* Boosts your metabolism. Dr. Alexandra C. McPherron, the lead scientist said, "increasing skeletal muscle mass by inhibiting signaling of myostatin, a transforming growth factor β (TGFβ) family member that negatively regulates muscle growth, prevents the development of diabetes in a mouse model of lipodystrophy. Muscle-specific myostatin inhibition also prevented hyperphagia suggesting muscle may regulate food intake".
In other words, increasing muscle mass improve your body metabolism.
* Improves Bone Mass. Dr. Colletti LAand colleagues said, "additional evidence that muscle-building exercise is associated with increases in BMD at weight-bearing sites but not at on weight-bearing sites".
* Reduces fat accumulation. Dr. Silva TR, the lead scientist wrote, "Skeletal muscle mass index (SMI) was positively correlated with physical activity (r = 0.205, P = 0.038) and protein intake (r = 0.334, P = 0.001), and negatively correlated with waist circumference (r = -0.505, P < 0.001) and %body fat (r = 0.808, P < 0.001)".
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean. The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent anti-aging compound, researchers examined the effects of ashwagandha root extract on muscle mass and strength in healthy young men engaged in resistance training.
The randomized, prospective, double-blind, placebo-controlled clinical study included 57 young male subjects (18-50 years old) with little experience in resistance training randomized into treatment received 300 mg of ashwagandha root extract twice daily, (29 subjects) and placebo, consumed starch placebos (28 subjects) groups.
Besides baseline measurements, both groups also underwent resistance training for 8 weeks with measurements repeated at the end of week 8.
Based on the results of measurement of the participants in both groups, compared to placebo, the treatment group showed significantly greater increases i
* In muscle strength on the bench-press exercise (Placebo: 26.4 kg vs. Ashwagandha: 46.0 kg)
* In the leg-extension exercise (Placebo: 9.8 kg) vs. Ashwagandha: 14.5 kg)
* In muscle size increase at the arms (Placebo: 5.3 cm(2) vs. Ashwagandha: 8.6 cm(2))
* In chest (Placebo: 1.4 cm vs. Ashwagandha: 3.3 cm).
Furthermore, ashwagandha treated group also had a significantly greater reduction of exercise-induced muscle damage.
Moreover, Ashwagandha treated group also showed a significantly greater increase in testosterone level (Placebo: 18.0 ng/dL Ashwagandha: 96.2 ng/dL)
More importantly, there was a significantly greater decrease in body fat percentage in treament group compared to placebo (Placebo: 1.5% vs. Ashwagandha: 3.5%).
Based on the finding, researchers wrote, "ashwagandha supplementation is associated with significant increases in muscle mass and strength and suggests that ashwagandha supplementation may be useful in conjunction with a resistance training program".
Taken altogether, Ashwagandha may be used as a supplement for the improvement of muscle mass and strength in the resistance training program, pending to the results from the large sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial by Wankhede S1, Langade D2, Joshi K3, Sinha SR4, Bhattacharyya S. (PubMed)
(2) Increasing muscle mass to improve metabolism by Alexandra C. McPherron, Tingqing Guo, Nichole D. Bond, and Oksana Gavrilova. (PMC)
(3) The effects of muscle-building exercise on bone mineral density of the radius, spine, and hip in young men by Colletti LA1, Edwards J, Gordon L, Shary J, Bell NH. (PubMed)
(4) Skeletal muscle mass is associated with higher dietary protein intake and lower body fat in postmenopausal women: a cross-sectional study by Silva TR1, Spritzer PM. (PubMed)
How to Cure Impetigo Naturally With No Adverse Effects, US National Library of Medicine Studies Suggestions
Green tea or tea lotion may have a therapeutic and positive effect better than conventional medicine Framycetin and Cephalexin gramicidin (soframycin) in treatment of impetigo, some scientists suggested.
The disease investigation was differentiated by numbers of institutes including Baghdad University and the results of the studies were published on online literature.
You can view the abstract of studies from PubMed, by clicking any of the resources' link.
Impetigo is a skin condition caused by bacterial skin infection with symptoms of blisters and sores,
around the nose and mouth, and on the arms or legs. In some case, it may appear in the facial area.
The disease infects mostly children.
In differentiated the effect of tea lotion against impetigo infected by bacteria, researchers at the Baghdad University conducted a study with participated of a total of 104 patients, including 47 females (45.2%) and 57 males (54.8%) with ages ranged from one month to 40 years with a median of 4 years.
Patients were randomly assigned to the treatment group with green tea applied to the infected areas and control group.
According to the diagnosis from the swabbed collected from patients, and analysed by microbiology impetigo contagiosa, pure S. aureus and combination of S. aureus and Streptococcus pyogenes were presented in 94.3% and 5.7% respectively in all patients.
These results suggested that the prevalent risk of impetigo is mostly caused by the infection of S. aureus.
Application tea lotion, including green tea, demonstrated a significant effect in reduced infectious areas substantially with the successfully cured rate of 81.3% in compared to control nontreatment group.
In examining the 40 patients in control group further assigned to 2 groups received either an ointment containing Framycetin or gramicidin (soframycin), researchers found that Framycetin and cephalexin gramicidin (soframycin) exerted a potential a cure rate of only 72.2% and 78.6%, respectively.
The results suggested that tea ointment or lotion displayed a better effect in treating impetigo in compared to conventional medicine Framycetin and gramicidin (soframycin) without inducing any adverse effects.
Dr. Sharquie KE, after taking into account of other co and confounders said: "(tea lotion) demonstrated the anti-bacterial action of crude tea in vivo, against impetigo contagiosa".
In further evaluation of green tea effect in reduced prevalence of skin infection, researchers at the Oakland University William Beaumont School of Medicine Rochester showed that catechins found in green tea have shown promise for having antimicrobial effects, particular in the fractions of (-)-epicatechin (EC), (-)-epicatechin-3-gallate (ECG), (-)-epigallocatechin (EGC), and (-)-epigallocatechin-3-gallate (EGCG).
Researchers continued, application of green tea bioactive catechin exhibited a variety of antimicrobial mechanisms and may be considered as a potential for preventive and therapeutic purposes.
In fact, relatively low concentrations of ECG was found to sensitize methicillin-resistant S. aureus (MRSA) clinical isolates to levels of oxacillin.
And, Catechin gallates such as ECG also showed to intercalate into phospholipid bilayers, affecting both virulence and antibiotic resistance by perturbing the function of the bacterial process of invasion.
The results may be attributed to green tea effect in reduced key processes associated with the bacterial cytoplasmic membrane.
However, further data collection on studies performed with human consumption during the course of infections, and studies on the occurrence of infections in populations that consume regular amounts of green tea will be necessary to complete the picture of its antimicrobial possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) The antibacterial activity of tea in vitro and in vivo (in patients with impetigo contagiosa).
Sharquie KE1, al-Turfi IA, al-Salloum SM.(PubMed)
(2) Antimicrobial properties of green tea catechins by Taylor PW1, Hamilton-Miller JM, Stapleton PD.(PubMed)
(3) The antimicrobial possibilities of green tea by Reygaert WC1.(PubMed)
The disease investigation was differentiated by numbers of institutes including Baghdad University and the results of the studies were published on online literature.
You can view the abstract of studies from PubMed, by clicking any of the resources' link.
Impetigo is a skin condition caused by bacterial skin infection with symptoms of blisters and sores,
around the nose and mouth, and on the arms or legs. In some case, it may appear in the facial area.
The disease infects mostly children.
In differentiated the effect of tea lotion against impetigo infected by bacteria, researchers at the Baghdad University conducted a study with participated of a total of 104 patients, including 47 females (45.2%) and 57 males (54.8%) with ages ranged from one month to 40 years with a median of 4 years.
Patients were randomly assigned to the treatment group with green tea applied to the infected areas and control group.
According to the diagnosis from the swabbed collected from patients, and analysed by microbiology impetigo contagiosa, pure S. aureus and combination of S. aureus and Streptococcus pyogenes were presented in 94.3% and 5.7% respectively in all patients.
These results suggested that the prevalent risk of impetigo is mostly caused by the infection of S. aureus.
Application tea lotion, including green tea, demonstrated a significant effect in reduced infectious areas substantially with the successfully cured rate of 81.3% in compared to control nontreatment group.
In examining the 40 patients in control group further assigned to 2 groups received either an ointment containing Framycetin or gramicidin (soframycin), researchers found that Framycetin and cephalexin gramicidin (soframycin) exerted a potential a cure rate of only 72.2% and 78.6%, respectively.
The results suggested that tea ointment or lotion displayed a better effect in treating impetigo in compared to conventional medicine Framycetin and gramicidin (soframycin) without inducing any adverse effects.
Dr. Sharquie KE, after taking into account of other co and confounders said: "(tea lotion) demonstrated the anti-bacterial action of crude tea in vivo, against impetigo contagiosa".
In further evaluation of green tea effect in reduced prevalence of skin infection, researchers at the Oakland University William Beaumont School of Medicine Rochester showed that catechins found in green tea have shown promise for having antimicrobial effects, particular in the fractions of (-)-epicatechin (EC), (-)-epicatechin-3-gallate (ECG), (-)-epigallocatechin (EGC), and (-)-epigallocatechin-3-gallate (EGCG).
Researchers continued, application of green tea bioactive catechin exhibited a variety of antimicrobial mechanisms and may be considered as a potential for preventive and therapeutic purposes.
In fact, relatively low concentrations of ECG was found to sensitize methicillin-resistant S. aureus (MRSA) clinical isolates to levels of oxacillin.
And, Catechin gallates such as ECG also showed to intercalate into phospholipid bilayers, affecting both virulence and antibiotic resistance by perturbing the function of the bacterial process of invasion.
The results may be attributed to green tea effect in reduced key processes associated with the bacterial cytoplasmic membrane.
However, further data collection on studies performed with human consumption during the course of infections, and studies on the occurrence of infections in populations that consume regular amounts of green tea will be necessary to complete the picture of its antimicrobial possibilities.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) The antibacterial activity of tea in vitro and in vivo (in patients with impetigo contagiosa).
Sharquie KE1, al-Turfi IA, al-Salloum SM.(PubMed)
(2) Antimicrobial properties of green tea catechins by Taylor PW1, Hamilton-Miller JM, Stapleton PD.(PubMed)
(3) The antimicrobial possibilities of green tea by Reygaert WC1.(PubMed)
Saturday, September 28, 2019
Phytochemical Alliin, The Best Natural Antioxidants
Antioxidants are stable atoms that inhibit oxidation caused by free radicals.
Free radicals, on the other hand, are unstable atoms with an unpaired electron in the outermost ring.
Therefore, in order for them to achieve stable, free radicals are always ready to intercept or donate an electron to other stable atoms, leading to a cascade that cannot be stopped until all electrons in the outermost ring are paired or inhibited by antioxidants.
Overexpression of free radicals in the long-term can lead to oxidative stress, leading to proteins and lipids and cell damage in facilitating the onset of cardiovascular disease, diabetes, neuro diseases,... and caners.
Most cases of oxidative stress is a result of an imbalance of the ratio of the levels of free radicals and antioxidant.
Believe it or not, free radicals in a moderate amount and in the control of the presence of antioxidant are essential for the body in food and energy metabolism and blood circulation.
Dr. V. Lobo, the lead scientist in the evaluation of "Free radicals, antioxidants, and functional foods: Impact on human health". wrote, "Free radicals reactive oxygen species and reactive nitrogen species are generated by our body by various endogenous systems, exposure to different physiochemical conditions or pathological states. A balance between free radicals and antioxidants is necessary for proper physiological function".
And, " Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole have recently been reported to be dangerous for human health. Thus, the search for effective, nontoxic natural compounds with antioxidative activity has been intensified in recent years".
The results suggested by maintaining an adequate amount of functional foods (not synthetic antioxidants) with plenty of antioxidants, oxidative stress may be preventable.
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
With an aim to find the potential compound for the treatment of diseases associated with oxidative stress, researchers examined the antioxidant activity of bioactive compound alliin.
Compared to garlic compounds representing the four main chemical classes, alliin, allyl cysteine, allyl disulfide, and allicin, prepared by chemical synthesis or purification, researchers found that alliin showed a better-scavenged superoxide property, particularly in hydroxyl radicals compared to others compound.
Allicin, a derivative of alliin suppressed the formation of superoxide by the xanthine/xanthine oxidase system, probably via a thiol and allicin exchange mechanism in the prevention of formation of free radicals.
However, Alliin and allicin did not prevent induced microsomal lipid peroxidation.
In other words, alliin is antioxidants with the free radical scavenging property.
Dr. Chung LY said in the final report, "allyl disulfide, alliin, allicin, and allyl cysteine exhibit different patterns of antioxidant activities as protective compounds against free radical damage".
In bone resorption associated with osteoclast differentiation and fusion, alliin (S-allyl-l-cysteine sulfoxides, SACSO) displayed a significant antioxidant activity by inhibiting the osteoclastogenesis with a dose-dependent manner via blocking the (c-Fos-NFATc1) signaling pathway involved cell differentiation and fusion.
Furthermore, alliin protected the bone density by decreasing the generation of reactive oxygen species (ROS) and inhibiting the expression of (NADPH oxidase 1 (Nox1)) protein associated with elevated ROS reactive oxygen.
Taken altogether, alliin may be considered supplements for the prevention and treatment of diseases involved in oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The antioxidant properties of garlic compounds: allyl cysteine, alliin, allicin, and allyl disulfide by Chung LY. (PubMed)
(2) Alliin Attenuated RANKL-Induced Osteoclastogenesis by Scavenging Reactive Oxygen Species through Inhibiting Nox by Chen Y1,2, Sun J3, Dou C4, Li N5, Kang F6, Wang Y7, Cao Z8, Yang X9, Dong S. (PubMed)
(3) Free radicals, antioxidants, and functional foods: Impact on human health by V. Lobo, A. Patil, A. Phatak, and N. Chandra. (PubMed)
Free radicals, on the other hand, are unstable atoms with an unpaired electron in the outermost ring.
Therefore, in order for them to achieve stable, free radicals are always ready to intercept or donate an electron to other stable atoms, leading to a cascade that cannot be stopped until all electrons in the outermost ring are paired or inhibited by antioxidants.
Overexpression of free radicals in the long-term can lead to oxidative stress, leading to proteins and lipids and cell damage in facilitating the onset of cardiovascular disease, diabetes, neuro diseases,... and caners.
Most cases of oxidative stress is a result of an imbalance of the ratio of the levels of free radicals and antioxidant.
Believe it or not, free radicals in a moderate amount and in the control of the presence of antioxidant are essential for the body in food and energy metabolism and blood circulation.
Dr. V. Lobo, the lead scientist in the evaluation of "Free radicals, antioxidants, and functional foods: Impact on human health". wrote, "Free radicals reactive oxygen species and reactive nitrogen species are generated by our body by various endogenous systems, exposure to different physiochemical conditions or pathological states. A balance between free radicals and antioxidants is necessary for proper physiological function".
And, " Synthetic antioxidants such as butylated hydroxytoluene and butylated hydroxyanisole have recently been reported to be dangerous for human health. Thus, the search for effective, nontoxic natural compounds with antioxidative activity has been intensified in recent years".
The results suggested by maintaining an adequate amount of functional foods (not synthetic antioxidants) with plenty of antioxidants, oxidative stress may be preventable.
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
With an aim to find the potential compound for the treatment of diseases associated with oxidative stress, researchers examined the antioxidant activity of bioactive compound alliin.
Compared to garlic compounds representing the four main chemical classes, alliin, allyl cysteine, allyl disulfide, and allicin, prepared by chemical synthesis or purification, researchers found that alliin showed a better-scavenged superoxide property, particularly in hydroxyl radicals compared to others compound.
Allicin, a derivative of alliin suppressed the formation of superoxide by the xanthine/xanthine oxidase system, probably via a thiol and allicin exchange mechanism in the prevention of formation of free radicals.
However, Alliin and allicin did not prevent induced microsomal lipid peroxidation.
In other words, alliin is antioxidants with the free radical scavenging property.
Dr. Chung LY said in the final report, "allyl disulfide, alliin, allicin, and allyl cysteine exhibit different patterns of antioxidant activities as protective compounds against free radical damage".
In bone resorption associated with osteoclast differentiation and fusion, alliin (S-allyl-l-cysteine sulfoxides, SACSO) displayed a significant antioxidant activity by inhibiting the osteoclastogenesis with a dose-dependent manner via blocking the (c-Fos-NFATc1) signaling pathway involved cell differentiation and fusion.
Furthermore, alliin protected the bone density by decreasing the generation of reactive oxygen species (ROS) and inhibiting the expression of (NADPH oxidase 1 (Nox1)) protein associated with elevated ROS reactive oxygen.
Taken altogether, alliin may be considered supplements for the prevention and treatment of diseases involved in oxidative stress, pending to the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The antioxidant properties of garlic compounds: allyl cysteine, alliin, allicin, and allyl disulfide by Chung LY. (PubMed)
(2) Alliin Attenuated RANKL-Induced Osteoclastogenesis by Scavenging Reactive Oxygen Species through Inhibiting Nox by Chen Y1,2, Sun J3, Dou C4, Li N5, Kang F6, Wang Y7, Cao Z8, Yang X9, Dong S. (PubMed)
(3) Free radicals, antioxidants, and functional foods: Impact on human health by V. Lobo, A. Patil, A. Phatak, and N. Chandra. (PubMed)
Green Tea and its Bioactive epigallocatechin 3-gallate (EGCG) in Attenuated Risk, progression of Fibromyalgia Caused by Inflammatory Rheumatic Disorders
Green tea may have a therapeutic and positive effect in reduced onset, progression and treatment of inflammatory rheumatic disorders induced fibromyalgia, some scientists suggested.
Green tea is a precious drink processed numbers of health benefit known to almost everyone in Asia and the Western world.
Fibromyalgia (FM) is a chronic condition characterized by muscle and soft tissue pain, affecting over 10 million (3.6% of the population) people in the US alone.
The inflammatory rheumatic disorder is a condition of autoimmune diseases caused inflammatory connective tissues, joint, and vessels of the body, including rheumatoid arthritis, systemic lupus erythematosus, and vasculitis.
According to the Cairo University, as many as 15-30% of patients with classic inflammatory rheumatic disorders also have co-morbid fibromyalgia syndrome (FMS) compared to the rate of only 2% of the prevalence of FMS in the general population (2%).
These results suggested that rheumatological syndromes have a strong implication in the development of fibromyalgia syndrome (FMS) compared to other initiators such as stress.
Therefore, patients with chronic rheumatic diseases are capable of triggering condition of fibromyalgia syndrome (FMS).
Due to the highly correlated rheumatologic disease and FMS component, researchers postulated "Considerations of the FMS component in the management of rheumatologic diseases increase the likelihood of the success of the treatment" and "(prevented) FMS in misdiagnosed as an autoimmune disorder"
In the study of the effect of green tea's active ingredient, epigallocatechin 3-gallate (EGCG) in risk of inflammatory rheumatic disorders in collagen-induced arthritis (CIA) in mice, researchers found that application of green tea demonstrates a substantially marked inhibition of the inflammatory mediators cyclooxygenase (COX) -2 in converting arachidonic acid in stimulated production of proinflammatory cytokine prostaglandin H2, in catalyzation of symptoms of inflammation in the muscles.
Furthermore, green tea EGCG oral ingestion also inhibited levels of interferon-gamma in precipitated inflammation by modulating T-cells and natural killer cells activated by antigens, mitogens or alloantigens to the site of infection.
Tumor necrosis factor-alpha (TNFα) involved in systemic inflammation, one of the cytokines that make up the acute phase reaction in mice was also inhibited by injection of green tea EGCG.
These result suggested that green tea ameliorated symptoms expression of inflammatory rheumatic disorders, through attenuating production pro-inflammatory factors without reducing the healing progression of injured tissue.
The above differentiation was supported by the study of green tea extract GTE in modestly ameliorated rat adjuvant-induced arthritis.
According to researchers, a daily per-oral administration of GTE (200 mg/kg) reduced expression of RA through reduced levels of MCP-1/CCL2 in expression (which can also be treated by biological agents, such as antibodies and inhibitory peptides) of a variety of diseases characterized by mononuclear cell infiltration involved substantial biological and genetic evidence, including RA.
and GROα/CXCL1 in the recruitment of inflammatory cells in the wound healing process after injury in angiogenesis and information of granulation tissue of wounds.
Additionally, application of green tea beside attenuated the expression of proinflammatory factors, its also exhibited the production of chemokine receptors CCR-1, CCR-2, CCR-5 in reduced direct communication between the innate and adaptive immune responses in initiated the development of inflammatory responses. through inactivation of leukocytes in inflamed tissues in contribution to the pathogenesis of inflammatory and autoimmune diseases.
And CXCR1 receptor in binding to IL-8 in reduced expression some inflammatory cytokines in initiated inflammation such as epidermal growth factor (EGF) and tumor necrosis factor-α (TNF-α).
Some researchers suggested that application of green tea extract may also reduce the symptoms of arthritis through expression of IL-6 levels, as increased levels of Il-6 was associated to the presence and progression of rheumatoid arthritis (RA) found in conventional clinical and laboratory indices and MMP-2 activity in activated immune-inflammatory response through inducing production of pro-inflammatory factors.
Taken together, green tea and its bioactive compound such as EGCG may have a profound and therapeutic effect in reducing the onset, progression, and treatment of fibromyalgia induced by inflammatory rheumatic disorders through modulating the production of pro and anti-inflammatory proteins. However, the intake of green tea supplement should be taken with extreme care due to recent reports of acute liver toxicity.
For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA For Women
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Fibromyalgia and Rheumatic Diseases by Gheita TA*, El-Rabbat SM and Mahmoud NK(Open Access)
(2) Green tea polyphenol epigallocatechin 3-gallate in arthritis: progress and promise by Salahuddin Ahmed(PMC)
Green tea is a precious drink processed numbers of health benefit known to almost everyone in Asia and the Western world.
Fibromyalgia (FM) is a chronic condition characterized by muscle and soft tissue pain, affecting over 10 million (3.6% of the population) people in the US alone.
The inflammatory rheumatic disorder is a condition of autoimmune diseases caused inflammatory connective tissues, joint, and vessels of the body, including rheumatoid arthritis, systemic lupus erythematosus, and vasculitis.
According to the Cairo University, as many as 15-30% of patients with classic inflammatory rheumatic disorders also have co-morbid fibromyalgia syndrome (FMS) compared to the rate of only 2% of the prevalence of FMS in the general population (2%).
These results suggested that rheumatological syndromes have a strong implication in the development of fibromyalgia syndrome (FMS) compared to other initiators such as stress.
Therefore, patients with chronic rheumatic diseases are capable of triggering condition of fibromyalgia syndrome (FMS).
Due to the highly correlated rheumatologic disease and FMS component, researchers postulated "Considerations of the FMS component in the management of rheumatologic diseases increase the likelihood of the success of the treatment" and "(prevented) FMS in misdiagnosed as an autoimmune disorder"
In the study of the effect of green tea's active ingredient, epigallocatechin 3-gallate (EGCG) in risk of inflammatory rheumatic disorders in collagen-induced arthritis (CIA) in mice, researchers found that application of green tea demonstrates a substantially marked inhibition of the inflammatory mediators cyclooxygenase (COX) -2 in converting arachidonic acid in stimulated production of proinflammatory cytokine prostaglandin H2, in catalyzation of symptoms of inflammation in the muscles.
Furthermore, green tea EGCG oral ingestion also inhibited levels of interferon-gamma in precipitated inflammation by modulating T-cells and natural killer cells activated by antigens, mitogens or alloantigens to the site of infection.
Tumor necrosis factor-alpha (TNFα) involved in systemic inflammation, one of the cytokines that make up the acute phase reaction in mice was also inhibited by injection of green tea EGCG.
These result suggested that green tea ameliorated symptoms expression of inflammatory rheumatic disorders, through attenuating production pro-inflammatory factors without reducing the healing progression of injured tissue.
The above differentiation was supported by the study of green tea extract GTE in modestly ameliorated rat adjuvant-induced arthritis.
According to researchers, a daily per-oral administration of GTE (200 mg/kg) reduced expression of RA through reduced levels of MCP-1/CCL2 in expression (which can also be treated by biological agents, such as antibodies and inhibitory peptides) of a variety of diseases characterized by mononuclear cell infiltration involved substantial biological and genetic evidence, including RA.
and GROα/CXCL1 in the recruitment of inflammatory cells in the wound healing process after injury in angiogenesis and information of granulation tissue of wounds.
Additionally, application of green tea beside attenuated the expression of proinflammatory factors, its also exhibited the production of chemokine receptors CCR-1, CCR-2, CCR-5 in reduced direct communication between the innate and adaptive immune responses in initiated the development of inflammatory responses. through inactivation of leukocytes in inflamed tissues in contribution to the pathogenesis of inflammatory and autoimmune diseases.
And CXCR1 receptor in binding to IL-8 in reduced expression some inflammatory cytokines in initiated inflammation such as epidermal growth factor (EGF) and tumor necrosis factor-α (TNF-α).
Some researchers suggested that application of green tea extract may also reduce the symptoms of arthritis through expression of IL-6 levels, as increased levels of Il-6 was associated to the presence and progression of rheumatoid arthritis (RA) found in conventional clinical and laboratory indices and MMP-2 activity in activated immune-inflammatory response through inducing production of pro-inflammatory factors.
Taken together, green tea and its bioactive compound such as EGCG may have a profound and therapeutic effect in reducing the onset, progression, and treatment of fibromyalgia induced by inflammatory rheumatic disorders through modulating the production of pro and anti-inflammatory proteins. However, the intake of green tea supplement should be taken with extreme care due to recent reports of acute liver toxicity.
For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA For Women
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Fibromyalgia and Rheumatic Diseases by Gheita TA*, El-Rabbat SM and Mahmoud NK(Open Access)
(2) Green tea polyphenol epigallocatechin 3-gallate in arthritis: progress and promise by Salahuddin Ahmed(PMC)
Friday, September 27, 2019
Phytochemical Betanin, the Chemo Prevention and Treatment of Cancer
Cancer is a class of chronic disease associated with the alternation of cell DNA.
Most cases of cancer start in the cell on the surface of the inner lining of the organ tissue, before penetrating deeper into other layers to form a tumor.
Epidemiologically, most cases of cancer at the very early stage are asymptomatic. However, at the advanced stage, primary cancer cells can travel a distance away from the original site to infect other healthy tissues and organs.
Types of secondary metastasis can be classified into
1. Local spreading, lymph vessel, blood vessel
* Local spreading as soon as the cancer cells grow to its tumor size, it will invade the nearby area.
* Spread through lymph vessel
If some cancer cells detached from the primary tumor and travel, they can grow into secondary cancer but most of the time they are trapped in the nearby lymph nodes closest to the original tumor.
* Spread through blood circulation
Similar to spread through lymph vessel, cancer cells detached from an original tumor can enter the bloodstream by slipping pass the blood vessel wall and start growing into the secondary tumor as they are trapped into some small capillaries.
2. Travel of clumps of cancer along the channels
Sometimes, cancer cells detached from the primary tumor can travel through other channels and spread to some parts of the body that are more vulnerable to become metastatic sites than others.
3. The arrival of cancer cells at a distance site
The development of the survival of cancer cells gets trapped and grow into the second tumor.
4. Angiogenesis
Angiogenesis is a process involving the growth of new blood vessels from pre-existing vessels. The secondary tumor can persuade the adjacent tissue to build blood vessels by providing it with vital nutrients and oxygen.
At this stage, the overgrowth of the tumor may also press on the nerve cells, blood vessels, and healthy tissues, leading to specific symptoms, depending to the types of tumor accompanied by the general symptoms shared by all cancers.
Betanin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
In the urgency to find a potential and natural compound for the treatment of cancer with no side effects, researchers examined the effects of betanin (BET) in reducing the side effects of potent anticancer drugs e.g. doxorubicin (DOX) on the normal tissues in co-administration.
In order to overcome the incomplete oral absorption and low stability of BET that limits its application, synergistic effect of DOX@BET by a new pH-responsive nanocarrier via decoration of gelatin nanoparticles (GNPs) (methoxy poly (ethylene glycol)-poly ((2-dimethylamino) ethyl methacrylate-co-itaconic acid) (PGNPs) was designed.
According to the triggered release ability of drugs assays, the GNPs not only controlled the release of DOX and BET with adjusting the pH of the environment but also decreased the cell viability amount of breast cancer cells (MCF-7) compared to the free form of DOX or BET.
In other words, BET combined with DOX not only enhanced the chemo drug toxicity against cancer but also reduced the side effect found in the free form of DOX.
Furthermore, in two mouse lung tumor models, researchers at the Washington University School of Medicine investigated the chemopreventive activity of betanin by oral consumption.
The experiment included vinyl carbamate (VC) and benzo(a)pyrene (B(a)P) induced lung cancer female A/J mice with lung cancer were treated with betanin in drinking water.
According to the tested assays, injection of betanin significantly decreased tumor multiplicity and tumor load induced by both carcinogens by 20% and 39% in the VC lung model, and by 46% and 65% in the B(a)P lung model, respectively.
The efficacy of betanin in both lung cancer models has attributed to the phytochemical lung tumor inhibitory effects in the induction of apoptosis and inhibition of angiogenesis.
Dr. Zhang Q, the lead scientists after taking other factors into account wrote, " Our data show that betanin significantly inhibits lung tumorigenesis in A/J mice and merits investigation as a chemopreventive agent for human lung cancer:.
Taken altogether, betanin may be considered supplements for the prevention and treatment of cancer, pending to the confirmation of larger sample size and multicenter human study.
Intake of betanin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A novel smart PEGylated gelatin nanoparticle for co-delivery of doxorubicin and betanin: A strategy for enhancing the therapeutic efficacy of chemotherapy by Amjadi S1, Hamishehkar H2, Ghorbani M. (PubMed)
(2) Beetroot red (betanin) inhibits vinyl carbamate- and benzo(a)pyrene-induced lung tumorigenesis through apoptosis by Zhang Q1, Pan J, Wang Y, Lubet R, You M. (PubMed)
Most cases of cancer start in the cell on the surface of the inner lining of the organ tissue, before penetrating deeper into other layers to form a tumor.
Epidemiologically, most cases of cancer at the very early stage are asymptomatic. However, at the advanced stage, primary cancer cells can travel a distance away from the original site to infect other healthy tissues and organs.
Types of secondary metastasis can be classified into
1. Local spreading, lymph vessel, blood vessel
* Local spreading as soon as the cancer cells grow to its tumor size, it will invade the nearby area.
* Spread through lymph vessel
If some cancer cells detached from the primary tumor and travel, they can grow into secondary cancer but most of the time they are trapped in the nearby lymph nodes closest to the original tumor.
* Spread through blood circulation
Similar to spread through lymph vessel, cancer cells detached from an original tumor can enter the bloodstream by slipping pass the blood vessel wall and start growing into the secondary tumor as they are trapped into some small capillaries.
2. Travel of clumps of cancer along the channels
Sometimes, cancer cells detached from the primary tumor can travel through other channels and spread to some parts of the body that are more vulnerable to become metastatic sites than others.
3. The arrival of cancer cells at a distance site
The development of the survival of cancer cells gets trapped and grow into the second tumor.
4. Angiogenesis
Angiogenesis is a process involving the growth of new blood vessels from pre-existing vessels. The secondary tumor can persuade the adjacent tissue to build blood vessels by providing it with vital nutrients and oxygen.
At this stage, the overgrowth of the tumor may also press on the nerve cells, blood vessels, and healthy tissues, leading to specific symptoms, depending to the types of tumor accompanied by the general symptoms shared by all cancers.
Betanin is phytochemicals in the class of red and yellow indole-derived pigments of Betacyanins, belonging to the group of Betalains, found abundantly in beets, chard, etc.
In the urgency to find a potential and natural compound for the treatment of cancer with no side effects, researchers examined the effects of betanin (BET) in reducing the side effects of potent anticancer drugs e.g. doxorubicin (DOX) on the normal tissues in co-administration.
In order to overcome the incomplete oral absorption and low stability of BET that limits its application, synergistic effect of DOX@BET by a new pH-responsive nanocarrier via decoration of gelatin nanoparticles (GNPs) (methoxy poly (ethylene glycol)-poly ((2-dimethylamino) ethyl methacrylate-co-itaconic acid) (PGNPs) was designed.
According to the triggered release ability of drugs assays, the GNPs not only controlled the release of DOX and BET with adjusting the pH of the environment but also decreased the cell viability amount of breast cancer cells (MCF-7) compared to the free form of DOX or BET.
In other words, BET combined with DOX not only enhanced the chemo drug toxicity against cancer but also reduced the side effect found in the free form of DOX.
Furthermore, in two mouse lung tumor models, researchers at the Washington University School of Medicine investigated the chemopreventive activity of betanin by oral consumption.
The experiment included vinyl carbamate (VC) and benzo(a)pyrene (B(a)P) induced lung cancer female A/J mice with lung cancer were treated with betanin in drinking water.
According to the tested assays, injection of betanin significantly decreased tumor multiplicity and tumor load induced by both carcinogens by 20% and 39% in the VC lung model, and by 46% and 65% in the B(a)P lung model, respectively.
The efficacy of betanin in both lung cancer models has attributed to the phytochemical lung tumor inhibitory effects in the induction of apoptosis and inhibition of angiogenesis.
Dr. Zhang Q, the lead scientists after taking other factors into account wrote, " Our data show that betanin significantly inhibits lung tumorigenesis in A/J mice and merits investigation as a chemopreventive agent for human lung cancer:.
Taken altogether, betanin may be considered supplements for the prevention and treatment of cancer, pending to the confirmation of larger sample size and multicenter human study.
Intake of betanin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A novel smart PEGylated gelatin nanoparticle for co-delivery of doxorubicin and betanin: A strategy for enhancing the therapeutic efficacy of chemotherapy by Amjadi S1, Hamishehkar H2, Ghorbani M. (PubMed)
(2) Beetroot red (betanin) inhibits vinyl carbamate- and benzo(a)pyrene-induced lung tumorigenesis through apoptosis by Zhang Q1, Pan J, Wang Y, Lubet R, You M. (PubMed)
Green tea and Its Bioactive Polyphenols in Protection of Cartilage Inside The Joint in Patients of Arthritis
Green tea may have a therapeutic and positive effect in the protection of the cartilage against the degeneration of arthritis in the joint, some scientists suggested.
Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.
Cartilage is a connected tissue, rubber-like padding between the joint of the bone with function to protect against bones rubbing against each other at the endpoints.
In the study of adolescent male Wistar rats 12-week exposure to Cd and Pb (7mg Cd and 50mg Pb in 1kg of the diet randomly assigned to 12 to each group, as positive control received without Cd, Pb and teas, a negative control group received Cd and Pb, and groups supplemented additionally with green (GT), black (BT), red (RT), and white tea (WT), application of tea significant inhibited the decreased levels of the geometric(shape) and densitometric(density) parameters and total thickness of articular cartilage caused by Cd and Pb in compared to the negative control group.
Tea injection group also displayed a huge improvement in mechanical endurance, growth plate thickness, and trabecular histomorphometry depending on the tea type.
Due to the limitation of the study, dr. Tomaszewska E, the lead researcher said, " It is difficult to indicate which tea has the best protective effects on bone and hyaline cartilage against heavy metal action".
Some scientists insisted that green tea with bioactive epigallocatechin-3-gallate, a green tea polyphenol, may be the one was contributed to the cartilage protection against various types of influence.
Application of green tea EGCG in drinking water of mice was found to prevent collagen-induced arthritis through inhibiting the production of certain pro-inflammatory factors in association of damage of collagen such as tumor necrosis factor-alpha (TNFα), a cell-signaling cytokine with pro-inflammatory involvement in systemic inflammation and cyclooxygenase-2, an enzyme in response to inflammation and pain.
In EGCG treatment of human chondrocytes derived from OA cartilage, the application inhibited and modulated IL-1β cytokines in induced activity and expression of cyclooxygenase-2 through its immune and inflammatory signaling and production of nitric oxide in the contribution of T lymphocyte dysfunction. and prostaglandin E2 in promotion of inflammation in chondrocytes.
According to the study, the inhibition of IL-1β by EGCG in human chondrocytes was also associated with its inhibitory effects on the activation of the nuclear translocation of NF-κB in the expression of proinflammatory activity.
Dr. Santosh K Katiya, the lead author, after taking into account of other co-founders said, "These data thus provide a mechanistic link in the prevention of arthritis responses as well as potential therapeutic value for EGCG/GTPs inhibiting cartilage resorption in arthritic joints".
Truly, in investigated the effects of catechins found in green tea on cartilage extracellular matrix components using bovine nasal and metacarpophalangeal cartilage as well as human non diseased, osteoarthritis and rheumatoid cartilage cultured with and without reagents known to accelerate cartilage matrix breakdown in vitro, researchers found that catechins, containing gallate ester, were most effective in inhibited proteoglycan and type II collagen breakdown without inducing adverse effects.
These results suggested that some green tea catechins may have a significant effect in protected or delayed against cartilage reduction and joint damage through the protection of chondrocytes.
Dr. Adcocks C, the lead author said, "green tea may be prophylactic for arthritis and may benefit the arthritis patient by reducing inflammation and slowing cartilage breakdown".
Taken together, green tea with bioactive polyphenols may be considered as a functional food for reduced or delayed progression of cartilage damage against type II collagen degradation and used the combination with standard medicine for the treatment of cartilage inside the joints in arthritis patients.
For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA For Women
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Alteration in bone geometric and mechanical properties, histomorphometrical parameters of trabecular bone, articular cartilage, and growth plate in adolescent rats after chronic co-exposure to cadmium and lead in the case of supplementation with green, black, red and white tea by Tomaszewska E1, Dobrowolski P2, Winiarska-Mieczan A3, Kwiecień M3, Tomczyk A4, Muszyński S5, Radzki R4.(PubMed)
(2) Green tea: a new option for the prevention or control of osteoarthritis by Santosh K Katiyar
1,2 and Chander Raman(PMC)
(3) Catechins from green tea (Camellia sinensis) inhibit bovine and human cartilageproteoglycan and type II collagen degradation in vitro by Adcocks C1, Collin P, Buttle DJ.(PubMed)
Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.
Cartilage is a connected tissue, rubber-like padding between the joint of the bone with function to protect against bones rubbing against each other at the endpoints.
In the study of adolescent male Wistar rats 12-week exposure to Cd and Pb (7mg Cd and 50mg Pb in 1kg of the diet randomly assigned to 12 to each group, as positive control received without Cd, Pb and teas, a negative control group received Cd and Pb, and groups supplemented additionally with green (GT), black (BT), red (RT), and white tea (WT), application of tea significant inhibited the decreased levels of the geometric(shape) and densitometric(density) parameters and total thickness of articular cartilage caused by Cd and Pb in compared to the negative control group.
Tea injection group also displayed a huge improvement in mechanical endurance, growth plate thickness, and trabecular histomorphometry depending on the tea type.
Due to the limitation of the study, dr. Tomaszewska E, the lead researcher said, " It is difficult to indicate which tea has the best protective effects on bone and hyaline cartilage against heavy metal action".
Some scientists insisted that green tea with bioactive epigallocatechin-3-gallate, a green tea polyphenol, may be the one was contributed to the cartilage protection against various types of influence.
Application of green tea EGCG in drinking water of mice was found to prevent collagen-induced arthritis through inhibiting the production of certain pro-inflammatory factors in association of damage of collagen such as tumor necrosis factor-alpha (TNFα), a cell-signaling cytokine with pro-inflammatory involvement in systemic inflammation and cyclooxygenase-2, an enzyme in response to inflammation and pain.
In EGCG treatment of human chondrocytes derived from OA cartilage, the application inhibited and modulated IL-1β cytokines in induced activity and expression of cyclooxygenase-2 through its immune and inflammatory signaling and production of nitric oxide in the contribution of T lymphocyte dysfunction. and prostaglandin E2 in promotion of inflammation in chondrocytes.
According to the study, the inhibition of IL-1β by EGCG in human chondrocytes was also associated with its inhibitory effects on the activation of the nuclear translocation of NF-κB in the expression of proinflammatory activity.
Dr. Santosh K Katiya, the lead author, after taking into account of other co-founders said, "These data thus provide a mechanistic link in the prevention of arthritis responses as well as potential therapeutic value for EGCG/GTPs inhibiting cartilage resorption in arthritic joints".
Truly, in investigated the effects of catechins found in green tea on cartilage extracellular matrix components using bovine nasal and metacarpophalangeal cartilage as well as human non diseased, osteoarthritis and rheumatoid cartilage cultured with and without reagents known to accelerate cartilage matrix breakdown in vitro, researchers found that catechins, containing gallate ester, were most effective in inhibited proteoglycan and type II collagen breakdown without inducing adverse effects.
These results suggested that some green tea catechins may have a significant effect in protected or delayed against cartilage reduction and joint damage through the protection of chondrocytes.
Dr. Adcocks C, the lead author said, "green tea may be prophylactic for arthritis and may benefit the arthritis patient by reducing inflammation and slowing cartilage breakdown".
Taken together, green tea with bioactive polyphenols may be considered as a functional food for reduced or delayed progression of cartilage damage against type II collagen degradation and used the combination with standard medicine for the treatment of cartilage inside the joints in arthritis patients.
For More information of yoga lessons tailor to a complete well being for women, please visit: YOGA For Women
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Alteration in bone geometric and mechanical properties, histomorphometrical parameters of trabecular bone, articular cartilage, and growth plate in adolescent rats after chronic co-exposure to cadmium and lead in the case of supplementation with green, black, red and white tea by Tomaszewska E1, Dobrowolski P2, Winiarska-Mieczan A3, Kwiecień M3, Tomczyk A4, Muszyński S5, Radzki R4.(PubMed)
(2) Green tea: a new option for the prevention or control of osteoarthritis by Santosh K Katiyar
1,2 and Chander Raman(PMC)(3) Catechins from green tea (Camellia sinensis) inhibit bovine and human cartilageproteoglycan and type II collagen degradation in vitro by Adcocks C1, Collin P, Buttle DJ.(PubMed)
Thursday, September 26, 2019
Herbal Artichoke, the Potential Anti Mesothelioma Remedy, According to Researchers
Mesothelioma is a type of cancer that develops from the thin layer of tissue known as the mesothelium.
Most cases of mesothelioma are found on the lining of the lungs and chest wall, compared to other organs. Pleural mesothelioma is a cancer of the pleural lining of the lung.
Exposure to asbestos which has been banned is one of the most common causes of the disease. Some researchers suggested that inhaling asbestos can cause mesothelioma in many ways, including
* Induced chronic low-grade inflammation of mesothelial cells as the immune system can not completely drive out the fibers that cause damage to the lung, leading to the compromise.
* Long-term exposure of the asbestos can suppress the genes associated with limited cell cycle division and tumor suppression
* Long-term exposure are also found to alter the cell DNA, leading to cancer.
According to statistic, 2000 to 3,000 people are diagnosed with mesothelioma each year in the United States. The asbestos risk of pleural mesothelioma is in the range of 2 to 10 percent.
Most cases of malignant mesothelioma are closely associated with past occupational exposure.
However, asbestos is found persistently in our natural and built environments.
Besides most common cancer symptoms, patients with pleural mesothelioma at the advanced stage may also experience symptoms of dry cough or wheezing, shortness of breath (dyspnea), respiratory complications and pain in the chest or abdomen.
Some patients may also develop pleural effusion (fluid around the lungs), fever or night sweats, fatigue, and muscle weakness
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as a liver protective and detoxified agent, and for the treatment of digestive disorders, abdominal pain gas and bloating, etc.
In the concern of the malignant pleural mesothelioma, a poorly treated neoplasia by conventional medicine, arising from the pleural mesothelial lining, researchers examined leaf extract of Cynara scolymus in vitro and in vivo.
The study included tMSTO-211H, MPP-89 and NCI-H28 mesothelioma cell lines and untransformed mesothelial cells HMC, treated with increasing concentrations (ranging from 3 to 200 μg/ml) of artichoke leaf extract for 72 hrs.
Injection of the leaf extract not only inhibited strongly the cell proliferation but also affected the migration and tumor engraftment in the mesothelioma cell lines.
More precisely, MSTO-211H cells treated with the artichoke extract showed a change in the cellular morphology both in a short-term assay, compared to more resistant more resistance in the HMC cells.
In MSTO-211H, MPP-89 and NCI-H28 cells, injection of artichoke leaf extract inhibited the formation of cancer cell colony.
Astonishingly, dietary feeding with Cynara scolymus leaf extract showed a similar inhibition against the growth of mesothelioma xenografted tumors comparable to those of pemetrexed.
Where pemetrexed is a chemo medicine used for the treatment of cancer, including mesothelioma.
Dr. Claudio Pulito and colleagues suggested, "leaf extract of Cynara scolymus holds therapeutic potential for the treatment of mesothelioma".
Taken altogether, artichoke leaf extract may be considered a functioning remedy for the prevention and treatment of mesothelioma, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Cynara scolymus affects malignant pleural mesothelioma by promoting apoptosis and restraining invasion by Pulito C1, Mori F1, Sacconi A2, Casadei L3, Ferraiuolo M2, Valerio MC3, Santoro R1, Goeman F2, Maidecchi A4, Mattoli L4, Manetti C3, Di Agostino S2, Muti P5, Blandino G2,5, Strano S. (PMC)
Green Tea and its Bioactive Polyphenol Epigallocatechin 3-gallate (EGCG) in Alleviated Symptoms, Reduced Risk, Progression and Treatment of Arthritis
Green tea may have a therapeutic and positive effect in reduced risk and progression and treatment of arthritis, some scientists suggested.
Arthritis is a chronic condition characterized by painful inflammation and stiffness of the joints.
According to statistic, arthritis is the common autoimmune disorder affected over 50 million worldwide.
According to the College of Pharmacy, green tea epigallocatechin 3-gallate (EGCG) in preclinical studies displayed a significant effect in the treatment of arthritic disease.
In vitro, the application of green tea extract EGCG demonstrated activities in cartilage-preserving and chondroprotective action through reduced expression of proinflammatory IL-1β, TNFα, and IL-6
and modulated extracellular matrix (ECM) turnover induced changes of the biomechanical environment of chondrocytes and accelerate the degradation of cartilage as well as driving the progression of the disease in the presence of inflammation.
Normal extracellular matrix (ECM) is a composed collagen type II with function to provide tensile support for the tissue.
Further analysis in the expression of proinflammatory factors researchers found that the overexpression of proinflammatory cytokines IL-1 and IL-6 were associated correlatively in knee joints in arthritis and inhibition of IL-1 and IL-6 by green tea EGCG IL-1 showed to reduce joint damage.
Some researchers also suggested that Interleukin 1 (IL-1) is a crucial mediator of the inflammatory response, playing an important part in the body's natural responses and the development of pathological conditions leading to chronic inflammation.
In the expression of tumor necrosis factor (TNF), tumor necrosis factor-alpha(TNFα, cachexin, or cachectin), application of green tea inhibited the levels of TNFα in the induction of synovial fibroblast cytotoxicity.
Interestingly, in the study to evaluate the possible effects of the administration of green tea extract on the oxidative state of the liver and brain of adjuvant-induced arthritic rats, researchers indicated that green tea daily doses of 250 mg kg(-1) (59.8 mg catechins per kg) for 23 days displays a strong effect in decreased symptoms of arthritis by ameliorated diminutions in protein and lipid damage in liver, brain and plasma, through antioxidant effect in reduced levels of ROS in stimulated free radical chain reaction to initiate production of pro-inflammatory cytokines to precipitate chronic diseases.
Rats treated with green tea EGCG also showed a significant improvement in restored natural antioxidant glutathione (GSH) and protein thiol levels produced by the body, by exhibiting the activities of the antioxidant enzymes.
Moreover, green tea injection also normalized the activity of glucose 6-phosphate dehydrogenase, which is increased in the liver of arthritic patients and considered as a risk factor for the development of arthritis. Increased activity glucose 6-phosphate dehydrogenase was associated to reactive oxygen species (ROS) generated in oxidative metabolism in inflicted damage on all classes of macromolecules.
Additional differentiation of green tea EGCG immunomodulatory effects and mechanisms on experimental arthritis induced by collagen-induced arthritis (CIA) in mice in compared to control received phosphate-buffered saline (PBS), researchers found that application of green tea EGCG at dose of 10 mg/kg demonstrated a strong effect in ameliorated clinical symptoms and reduced histological scores in arthritic mice, through modulated the immune activity by induced overexpression of the Nrf-2 antioxidant pathway, a major mechanism in the cellular defense against oxidative or electrophilic stress through detoxication and elimination.
EGCG also ameliorated experimental arthritis in mice by eliciting indoleamine-2,3-dioxygenase (IDO) through inhibition of pro-inflammatory cytokine interferon-gamma, astrocytes and microglia in facilitated production of dendritic cells (DCs) in the activation of the immune system to attack the dendritic cell located on the surface on the joint tissue.
Application of the EGCG also increased frequencies of T regs with a dominant role in the suppression of autoimmune pathology.
Some researchers suggested that increased Treg number and/or function in model systems may have a significant effect on both prevented and reversed arthritis disease.
Taken together, green tea with abundant bioactive polyphenol epigallocatechin 3-gallate (EGCG) may be considered as a functional food for alleviated symptoms, reduced risk, and progression and treatment of arthritis.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea extract improves the oxidative state of the liver and brain in rats with adjuvant-induced arthritis by de Almeida Gonçalves G1, de Sá-Nakanishi AB, Wendt MM, Comar JF, Bersani Amado CA, Bracht A, Peralta RM.(PubMed)
(2) Green Tea Epigallocatechin-3-Gallate Suppresses Autoimmune Arthritis Through Indoleamine-2,3-Dioxygenase Expressing Dendritic Cells and the Nuclear Factor, Erythroid 2-Like 2 Antioxidant Pathway by Min SY1, Yan M1, Kim SB2, Ravikumar S1,3, Kwon SR1,4, Vanarsa K1,3, Kim HY4, Davis LS#1, Mohan C(PubMed)
(3) Green tea polyphenol epigallocatechin 3-gallate in arthritis: progress and promise by Ahmed S1.(PubMed)
(4) Is IL-1 a good therapeutic target in the treatment of arthritis? by Burger D1, Dayer JM, Palmer G, Gabay C.(PubMed)
Arthritis is a chronic condition characterized by painful inflammation and stiffness of the joints.
According to statistic, arthritis is the common autoimmune disorder affected over 50 million worldwide.
According to the College of Pharmacy, green tea epigallocatechin 3-gallate (EGCG) in preclinical studies displayed a significant effect in the treatment of arthritic disease.
In vitro, the application of green tea extract EGCG demonstrated activities in cartilage-preserving and chondroprotective action through reduced expression of proinflammatory IL-1β, TNFα, and IL-6
and modulated extracellular matrix (ECM) turnover induced changes of the biomechanical environment of chondrocytes and accelerate the degradation of cartilage as well as driving the progression of the disease in the presence of inflammation.
Normal extracellular matrix (ECM) is a composed collagen type II with function to provide tensile support for the tissue.
Further analysis in the expression of proinflammatory factors researchers found that the overexpression of proinflammatory cytokines IL-1 and IL-6 were associated correlatively in knee joints in arthritis and inhibition of IL-1 and IL-6 by green tea EGCG IL-1 showed to reduce joint damage.
Some researchers also suggested that Interleukin 1 (IL-1) is a crucial mediator of the inflammatory response, playing an important part in the body's natural responses and the development of pathological conditions leading to chronic inflammation.
In the expression of tumor necrosis factor (TNF), tumor necrosis factor-alpha(TNFα, cachexin, or cachectin), application of green tea inhibited the levels of TNFα in the induction of synovial fibroblast cytotoxicity.
Interestingly, in the study to evaluate the possible effects of the administration of green tea extract on the oxidative state of the liver and brain of adjuvant-induced arthritic rats, researchers indicated that green tea daily doses of 250 mg kg(-1) (59.8 mg catechins per kg) for 23 days displays a strong effect in decreased symptoms of arthritis by ameliorated diminutions in protein and lipid damage in liver, brain and plasma, through antioxidant effect in reduced levels of ROS in stimulated free radical chain reaction to initiate production of pro-inflammatory cytokines to precipitate chronic diseases.
Rats treated with green tea EGCG also showed a significant improvement in restored natural antioxidant glutathione (GSH) and protein thiol levels produced by the body, by exhibiting the activities of the antioxidant enzymes.
Moreover, green tea injection also normalized the activity of glucose 6-phosphate dehydrogenase, which is increased in the liver of arthritic patients and considered as a risk factor for the development of arthritis. Increased activity glucose 6-phosphate dehydrogenase was associated to reactive oxygen species (ROS) generated in oxidative metabolism in inflicted damage on all classes of macromolecules.
Additional differentiation of green tea EGCG immunomodulatory effects and mechanisms on experimental arthritis induced by collagen-induced arthritis (CIA) in mice in compared to control received phosphate-buffered saline (PBS), researchers found that application of green tea EGCG at dose of 10 mg/kg demonstrated a strong effect in ameliorated clinical symptoms and reduced histological scores in arthritic mice, through modulated the immune activity by induced overexpression of the Nrf-2 antioxidant pathway, a major mechanism in the cellular defense against oxidative or electrophilic stress through detoxication and elimination.
EGCG also ameliorated experimental arthritis in mice by eliciting indoleamine-2,3-dioxygenase (IDO) through inhibition of pro-inflammatory cytokine interferon-gamma, astrocytes and microglia in facilitated production of dendritic cells (DCs) in the activation of the immune system to attack the dendritic cell located on the surface on the joint tissue.
Application of the EGCG also increased frequencies of T regs with a dominant role in the suppression of autoimmune pathology.
Some researchers suggested that increased Treg number and/or function in model systems may have a significant effect on both prevented and reversed arthritis disease.
Taken together, green tea with abundant bioactive polyphenol epigallocatechin 3-gallate (EGCG) may be considered as a functional food for alleviated symptoms, reduced risk, and progression and treatment of arthritis.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Green tea extract improves the oxidative state of the liver and brain in rats with adjuvant-induced arthritis by de Almeida Gonçalves G1, de Sá-Nakanishi AB, Wendt MM, Comar JF, Bersani Amado CA, Bracht A, Peralta RM.(PubMed)
(2) Green Tea Epigallocatechin-3-Gallate Suppresses Autoimmune Arthritis Through Indoleamine-2,3-Dioxygenase Expressing Dendritic Cells and the Nuclear Factor, Erythroid 2-Like 2 Antioxidant Pathway by Min SY1, Yan M1, Kim SB2, Ravikumar S1,3, Kwon SR1,4, Vanarsa K1,3, Kim HY4, Davis LS#1, Mohan C(PubMed)
(3) Green tea polyphenol epigallocatechin 3-gallate in arthritis: progress and promise by Ahmed S1.(PubMed)
(4) Is IL-1 a good therapeutic target in the treatment of arthritis? by Burger D1, Dayer JM, Palmer G, Gabay C.(PubMed)
Wednesday, September 25, 2019
Healthy Food Turmeric, a Natural Prevention and Treatment of Ulcerative Colitis (UC)<, Researchers Say
Ulcerative colitis is a type of inflammatory bowel disease induced chronic inflammation and ulcers (sores) in the digestive tract.
The disease affects the colon and the rectum, leading to bloody diarrhea accompanied by symptoms of belly pain, not feeling hungry, fatigue, weight loss, dehydration.
Some patients may also experience symptoms of joint pain or soreness and sudden urges to empty the colon right away.
The UC is caused by the immune system mistakenly attacks the cell of the colon, leading to low-grade inflammation.
According to the statistic, in the US, approximately, 1.6 million Americans are living with inflammatory bowel disease, including 907,000 people with ulcerative colitis.
More precisely, the risk of people diagnosed with ulcerative colitis per 100,000 person-years is between 2 and 14.
Conventionally, the treatment of UC is focused on reduced symptoms and prevent the fare up. In some cases, surgery may be necessary if the medication fails.
The are many prevalent factors associated with UC, including aging, ethnicity, and family. However, some researchers suggested that the promotion of a high-fat diet over the past few decades may have a strong implication in inducing the rise of ulcerative colitis.
Dr. Mitsuro Chiba, the lead scientist wrote, " Diets rich in animal protein (risk factor) and deficient in dietary fiber (preventive factor) are characteristic of westernized diets in affluent societies. Recent research shows that westernized diets are associated with reduced gut microbial diversity (dysbiosis), which may result in increased susceptibility to IBD and other common chronic diseases".
And, "Plant-based diets rich in dietary fiber are associated with increased microbial diversity. Recent reports on IBD therapy that replaced westernized diets with plant-based diets achieved far better outcomes than those previously reported in the literature. We believe that westernized diet-associated gut dysbiosis is the most ubiquitous environmental factor in IBD".
The results strongly link the risk of IBD in people who follow the Western diet.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a potential compound for the treatment of ulcerative colitis, researchers conducted a systematical review and meta-analyze on the efficacy of oral curcumin administration as adjuvant therapy of UC. MEDLINE, Cochrane/CENTRAL, ClinicalTrials.gov, WHO-ICT.
According to the findings, With the M-H method, treatment with curcumin was significantly superior to placebo but not in the intention-to-treat (ITT) analysis.
However, with the more accurate B-B method, both analyses were found to be insignificant.
In other words, oral curcumin administration was not superior to placebo in attaining remission in patients with UC.
In other to clarify the effect of curcumin on UC, a joint study led by the Bassett Medical Center was conducted by searching the databases of medical literature in the MEDLINE, Pubmed, and Embase through December 2017.
According to the results of 3 randomized controlled trials including 142 patients included in the study, clinical improvement, endoscopic remission, and improvement rate also trended higher in the curcumin group compared to placebo.
In other words, higher clinical remission rates when curcumin was used in combination with mesalamine to achieve remission in patients with UC.
Dr. Iqb al U, the lead scientist wrote, "Curcumin, due to its cost-effectiveness and safer side effect profile, can decrease the healthcare burden and morbidity associated with this relapsing and remitting disease".
Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention of ulcerative colitis, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Oral Adjuvant Curcumin Therapy for Attaining Clinical Remission in Ulcerative Colitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Grammatikopoulou MG1,2,3, Gkiouras K4,5, Theodoridis X6,7, Asteriou E8, Forbes A9, Bogdanos DP. (PubMed)
(2) Use of Curcumin in Achieving Clinical and Endoscopic Remission in Ulcerative Colitis: A Systematic Review and Meta-analysis by Iqbal U1, Anwar H2, Quadri AA. (PubMed)
(3) Westernized Diet is the Most Ubiquitous Environmental Factor in Inflammatory Bowel Disease by Mitsuro Chiba, MD, PhD1; Kunio Nakane, MD, PhD1; Masafumi Komatsu, MD, Ph.D. (the Permanente Journal)
The disease affects the colon and the rectum, leading to bloody diarrhea accompanied by symptoms of belly pain, not feeling hungry, fatigue, weight loss, dehydration.
Some patients may also experience symptoms of joint pain or soreness and sudden urges to empty the colon right away.
The UC is caused by the immune system mistakenly attacks the cell of the colon, leading to low-grade inflammation.
According to the statistic, in the US, approximately, 1.6 million Americans are living with inflammatory bowel disease, including 907,000 people with ulcerative colitis.
More precisely, the risk of people diagnosed with ulcerative colitis per 100,000 person-years is between 2 and 14.
Conventionally, the treatment of UC is focused on reduced symptoms and prevent the fare up. In some cases, surgery may be necessary if the medication fails.
The are many prevalent factors associated with UC, including aging, ethnicity, and family. However, some researchers suggested that the promotion of a high-fat diet over the past few decades may have a strong implication in inducing the rise of ulcerative colitis.
Dr. Mitsuro Chiba, the lead scientist wrote, " Diets rich in animal protein (risk factor) and deficient in dietary fiber (preventive factor) are characteristic of westernized diets in affluent societies. Recent research shows that westernized diets are associated with reduced gut microbial diversity (dysbiosis), which may result in increased susceptibility to IBD and other common chronic diseases".
And, "Plant-based diets rich in dietary fiber are associated with increased microbial diversity. Recent reports on IBD therapy that replaced westernized diets with plant-based diets achieved far better outcomes than those previously reported in the literature. We believe that westernized diet-associated gut dysbiosis is the most ubiquitous environmental factor in IBD".
The results strongly link the risk of IBD in people who follow the Western diet.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a potential compound for the treatment of ulcerative colitis, researchers conducted a systematical review and meta-analyze on the efficacy of oral curcumin administration as adjuvant therapy of UC. MEDLINE, Cochrane/CENTRAL, ClinicalTrials.gov, WHO-ICT.
According to the findings, With the M-H method, treatment with curcumin was significantly superior to placebo but not in the intention-to-treat (ITT) analysis.
However, with the more accurate B-B method, both analyses were found to be insignificant.
In other words, oral curcumin administration was not superior to placebo in attaining remission in patients with UC.
In other to clarify the effect of curcumin on UC, a joint study led by the Bassett Medical Center was conducted by searching the databases of medical literature in the MEDLINE, Pubmed, and Embase through December 2017.
According to the results of 3 randomized controlled trials including 142 patients included in the study, clinical improvement, endoscopic remission, and improvement rate also trended higher in the curcumin group compared to placebo.
In other words, higher clinical remission rates when curcumin was used in combination with mesalamine to achieve remission in patients with UC.
Dr. Iqb al U, the lead scientist wrote, "Curcumin, due to its cost-effectiveness and safer side effect profile, can decrease the healthcare burden and morbidity associated with this relapsing and remitting disease".
Taken altogether, turmeric processed a high amount of bioactive compound curcumin may be considered supplements for the prevention of ulcerative colitis, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Oral Adjuvant Curcumin Therapy for Attaining Clinical Remission in Ulcerative Colitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Grammatikopoulou MG1,2,3, Gkiouras K4,5, Theodoridis X6,7, Asteriou E8, Forbes A9, Bogdanos DP. (PubMed)
(2) Use of Curcumin in Achieving Clinical and Endoscopic Remission in Ulcerative Colitis: A Systematic Review and Meta-analysis by Iqbal U1, Anwar H2, Quadri AA. (PubMed)
(3) Westernized Diet is the Most Ubiquitous Environmental Factor in Inflammatory Bowel Disease by Mitsuro Chiba, MD, PhD1; Kunio Nakane, MD, PhD1; Masafumi Komatsu, MD, Ph.D. (the Permanente Journal)
Green Tea and Its Bioactive Polyphenols That Inhibit Risk and Treatment of Candidiasis
Green tea may have a therapeutic and positive effect in reduced risk and progression and treatment of Candidiasis, some scientists suggested.
Candida albicans are members of a large group of microorganism whose cells contain complex structures enclosed within the membranes, including yeast, fungi, and mold, living among the gut flora in the human mouth and gastrointestinal tract.
Overgrowth of candida is also known as candidiasis, affecting the skin, including the skin of the vagina, the penis, and the mouth.
In severe cases, the yeast overgrowth also causes infection of the blood and internal organs such as the liver, lung, and spleen.
Some researchers suggested that candidiasis can weaken the immune function, therefore, the infection has a strongly negative implication in people with damaged immune diseases, such as AIDS. Particularly, people are treated with chemotherapy for cancer.
Unhealthy diet and lifestyle are associated with increased risk of candida overgrowth. The article, "Lifestyle Habits That Lead to Yeast Infections" By Gina Roberts-Grey and Reviewed by Rosalyn Carson-DeWitt, MD, wrote, ".....modifying some every day habits can alleviate yeast infection symptoms and reduce the odds you will have a vaginal infection" and “Many women don’t realize they have the ability to reduce their chances of developing a yeast infection”(4).
Symptoms of candidiasis are totally depending on the infected locations. Vaginal yeast infection can cause the discharge of a thick, white, clumpy (cottage-cheese-like) substance with odor, leading to itches, urinary burning sensation, and painful sexual intercourse.
In nail, the yeast infection can cause painful, red, swollen around the nail.
In the mouth, the infection may induce cracked, red at the corners of the mouth.
In the investigation of The effectiveness of the synergistic herbal-based composition of purified catechins with fluconazole, amphotericin B and copper sulphate against Candida albicans (MTCC 3017) and Candida glabrata (MTCC 3019), researchers found that* According to the time-kill assay, catechins demonstrated twice efficacy in the same at minimum inhibitory concentration in compared to antimycotics.
*Additional copper sulfate injection increased anticandidal efficacy of synergistic combinations by 0.4% to 6.63%.
* The combination significantly induced cytotoxicity with high percentage viability (≥91.4% to≥100%) of Vero cell line without inducing harm to nearby healthy cells.
Base on these results, Dr. Ning Y, the lead scientist said, "(the) present evaluated synergistic composition can confer promising anticandidal efficacy" and (However, These result) requires further investigation of safety and translational guidelines for effective and safer green tea-based potent therapeutic drug".
Further evaluation of green tea bioactive polyphenol epigallocatechin gallate (EGCG) in inhibited the growth of Candida albicans planktonic cells and enhanced the antifungal activity of antimycotics of Candida albicans, Candida parapsilosis, Candida tropicalis, Candida glabrata, Candida kefyr, and Candida krusei, the Nihon University School of Dentistry at Matsudo filed the reports as follows
* Green tea EGCG exerted a synergistic activity with miconazole, fluconazole or amphotericin B against most test planktonic and biofilm cells of Candida species (FIC≤0.5).
* All biofilm cells were significantly more resistant to EGCG and antimycotics (20-3200 times higher) in compared with their planktonic counterparts.
These results suggested, "EGCG enhances the antifungal effects of miconazole, fluconazole, and amphotericin B. Combined treatment with EGCG may lower the dosages of antimycotics, thus preventing adverse effects and the emergence of drug-resistant oral Candida species".
Interestingly, the assessment of antifungal activity of catechin pH dependently displayed that
* The concentration of epigallocatechin gallate (EGCg) causing 90% growth inhibition of tested strains of C. albicans was 2000 mg/L at pH 6.0, 500-1000 mg/L at pH 6.5 and 15.6-250 mg/L at pH 7.0.
* Among catechins, pyrogallol catechin showed stronger antifungal activity against C. albicans than catechol catechin.
* The addition of 6.25-25 or 3.12-12.5 mg/L EGCG to amphotericin B 0.125 or 0.25 mg/L (below MIC) at pH 7.0 resulted in enhancement, respectively, of the antifungal effect of amphotericin B against amphotericin B-susceptible or -resistant C. albicans.
* Combined treatment with 3.12-12.5 mg/L EGCg plus amphotericin B 0.5 mg/L (below MIC) markedly decreased the growth of amphotericin B-resistant C. albicans.
* Fluconazole-susceptible C. albicans was treated with 25-50 mg/L EGCg and fluconazole 0.125-0.25 mg/L (below MIC), its growth was inhibited by 93.0%-99.4% compared with its growth in the presence of fluconazole alone.
* The combined use of 12.5 mg/L EGCg and fluconazole 10-50 mg/L (below MIC) inhibited the growth of fluconazole-resistant C. albicans by 98.5%-99.7%.
The findings suggested that green tea extract and its bioactive polyphenols may be used alone to reduced risk and treatment or secondary therapy in enhanced standard medicine for the treatment of Candidiasis.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.caAuthor Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Anticandidal synergistic activity of green tea catechins, antimycotics and copper sulphate as a mean of combinational drug therapy against candidiasis by Anand J1, Rai N2(PubMed)
(2) Synergistic effects of tea catechin epigallocatechin gallate and antimycotics against oral Candida species by Ning Y1, Ling J2, Wu CD3.(PubMed)
(3) Multiple effects of green tea catechin on the antifungal activity of antimycotics against Candida albicans by Hirasawa M1, Takada K.(PubMed)
(4) Lifestyle Habits That Lead to Yeast Infections By Gina Roberts-Grey, Reviewed by Rosalyn Carson-DeWitt, MD
Candida albicans are members of a large group of microorganism whose cells contain complex structures enclosed within the membranes, including yeast, fungi, and mold, living among the gut flora in the human mouth and gastrointestinal tract.
Overgrowth of candida is also known as candidiasis, affecting the skin, including the skin of the vagina, the penis, and the mouth.
In severe cases, the yeast overgrowth also causes infection of the blood and internal organs such as the liver, lung, and spleen.
Some researchers suggested that candidiasis can weaken the immune function, therefore, the infection has a strongly negative implication in people with damaged immune diseases, such as AIDS. Particularly, people are treated with chemotherapy for cancer.
Unhealthy diet and lifestyle are associated with increased risk of candida overgrowth. The article, "Lifestyle Habits That Lead to Yeast Infections" By Gina Roberts-Grey and Reviewed by Rosalyn Carson-DeWitt, MD, wrote, ".....modifying some every day habits can alleviate yeast infection symptoms and reduce the odds you will have a vaginal infection" and “Many women don’t realize they have the ability to reduce their chances of developing a yeast infection”(4).
Symptoms of candidiasis are totally depending on the infected locations. Vaginal yeast infection can cause the discharge of a thick, white, clumpy (cottage-cheese-like) substance with odor, leading to itches, urinary burning sensation, and painful sexual intercourse.
In nail, the yeast infection can cause painful, red, swollen around the nail.
In the mouth, the infection may induce cracked, red at the corners of the mouth.
In the investigation of The effectiveness of the synergistic herbal-based composition of purified catechins with fluconazole, amphotericin B and copper sulphate against Candida albicans (MTCC 3017) and Candida glabrata (MTCC 3019), researchers found that* According to the time-kill assay, catechins demonstrated twice efficacy in the same at minimum inhibitory concentration in compared to antimycotics.
*Additional copper sulfate injection increased anticandidal efficacy of synergistic combinations by 0.4% to 6.63%.
* The combination significantly induced cytotoxicity with high percentage viability (≥91.4% to≥100%) of Vero cell line without inducing harm to nearby healthy cells.
Base on these results, Dr. Ning Y, the lead scientist said, "(the) present evaluated synergistic composition can confer promising anticandidal efficacy" and (However, These result) requires further investigation of safety and translational guidelines for effective and safer green tea-based potent therapeutic drug".
Further evaluation of green tea bioactive polyphenol epigallocatechin gallate (EGCG) in inhibited the growth of Candida albicans planktonic cells and enhanced the antifungal activity of antimycotics of Candida albicans, Candida parapsilosis, Candida tropicalis, Candida glabrata, Candida kefyr, and Candida krusei, the Nihon University School of Dentistry at Matsudo filed the reports as follows
* Green tea EGCG exerted a synergistic activity with miconazole, fluconazole or amphotericin B against most test planktonic and biofilm cells of Candida species (FIC≤0.5).
* All biofilm cells were significantly more resistant to EGCG and antimycotics (20-3200 times higher) in compared with their planktonic counterparts.
These results suggested, "EGCG enhances the antifungal effects of miconazole, fluconazole, and amphotericin B. Combined treatment with EGCG may lower the dosages of antimycotics, thus preventing adverse effects and the emergence of drug-resistant oral Candida species".
Interestingly, the assessment of antifungal activity of catechin pH dependently displayed that
* The concentration of epigallocatechin gallate (EGCg) causing 90% growth inhibition of tested strains of C. albicans was 2000 mg/L at pH 6.0, 500-1000 mg/L at pH 6.5 and 15.6-250 mg/L at pH 7.0.
* Among catechins, pyrogallol catechin showed stronger antifungal activity against C. albicans than catechol catechin.
* The addition of 6.25-25 or 3.12-12.5 mg/L EGCG to amphotericin B 0.125 or 0.25 mg/L (below MIC) at pH 7.0 resulted in enhancement, respectively, of the antifungal effect of amphotericin B against amphotericin B-susceptible or -resistant C. albicans.
* Combined treatment with 3.12-12.5 mg/L EGCg plus amphotericin B 0.5 mg/L (below MIC) markedly decreased the growth of amphotericin B-resistant C. albicans.
* Fluconazole-susceptible C. albicans was treated with 25-50 mg/L EGCg and fluconazole 0.125-0.25 mg/L (below MIC), its growth was inhibited by 93.0%-99.4% compared with its growth in the presence of fluconazole alone.
* The combined use of 12.5 mg/L EGCg and fluconazole 10-50 mg/L (below MIC) inhibited the growth of fluconazole-resistant C. albicans by 98.5%-99.7%.
The findings suggested that green tea extract and its bioactive polyphenols may be used alone to reduced risk and treatment or secondary therapy in enhanced standard medicine for the treatment of Candidiasis.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.caAuthor Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Anticandidal synergistic activity of green tea catechins, antimycotics and copper sulphate as a mean of combinational drug therapy against candidiasis by Anand J1, Rai N2(PubMed)
(2) Synergistic effects of tea catechin epigallocatechin gallate and antimycotics against oral Candida species by Ning Y1, Ling J2, Wu CD3.(PubMed)
(3) Multiple effects of green tea catechin on the antifungal activity of antimycotics against Candida albicans by Hirasawa M1, Takada K.(PubMed)
(4) Lifestyle Habits That Lead to Yeast Infections By Gina Roberts-Grey, Reviewed by Rosalyn Carson-DeWitt, MD
Tuesday, September 24, 2019
Turmeric, the Anti Hyperlipidemia Herbal Remedy
Hyperlipidemia or high blood cholesterol is a condition that causes abnormally high levels of lipids in the blood.
Cholesterol plays an essential role in moderate amount in orchestrating the production of steroid hormone and vitamin D, building strong cell walls and aiding the digestive system in absorbing nutrients and fluids.
Cholesterol can either be produced by the liver or consumed form the food sources. There are 2 types of cholesterol
*The high-density lipoprotein is also known as "good" cholesterol processes a function to return cholesterol to the liver.
* The low-density lipoprotein is also known as "bad" cholesterol processed a function aforementioned health benefits in moderate amount.
In a healthy individual, the bad cholesterol is returned to the liver. However, overexpression of "bad" cholesterol due to the consumption of a high-fat diet and reduced levels of "good" cholesterol can induce an unhealthy ratio of bad and good cholesterol, leading to bad cholesterol remaining in the bloodstream, a cause of hyperlipidemia.
Overexpression of bad cholesterol has been found to facilitate the plaque accumulated in the arterial wall, a major cause of heart disease and stroke.
According to the statistics provided by the CDC, in 2015–2016, more than 12% of adults age 20 and older had total cholesterol higher than 240 mg/dL, and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL in the US.
Conventionally, hyperlipidemia is treated by simvastatin, lovastatin, atorvastatin, and rosuvastatin. However, holistically, by a change of diet and daily moderate exercise, you may control the condition without medication.
Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On findings a potential compound for the treatment of hyperlipidemia, researchers investigated the effects of curcumin on hyperlipidemia and hepatic steatosis in high-fructose-fed Wistar rats.
Rat groups selected to the study were divided into four groups with 10 rats in each group with two groups fed with standard rodent diet with or without plus curcumin (200 mg/kg body weight) and the other two with 60% high-fructose diet with or without curcumin (200 mg/kg body weight)for 10 weeks.
According to the results of differentiation, co-administration of curcumin reduced body weight, liver weight, adipose weight, plasma levels of TAG, VLDL-C associated with the onset of hyperlipidemia compared to the untreated group.
Additionally, curcumin also increased the levels of lipid ratios in favors of the HDL-C by increasing the levels of HDL-C (28.4 ± 4.5 mg/dL) in fructose-fed rats compared to standard rodent diet rats.
The protein expression of LXR-α (43%) and SREBP1c (59%) associated with inflammation and activation of cholesterol in the liver were also decreased by the injection curcumin.
More importantly, curcumin suppressed the expression of lipogenic enzymes associated with lipid metabolism and genes involved in cholesterol production in rats fed with a high-fructose diet.
Based on the findings, researchers said, "Curcumin prevented the high-fructose induced hyperlipidemia and hepatic steatosis".
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of hyperlipidemia, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin inhibits hyperlipidemia and hepatic fat accumulation in high-fructose-fed male Wistar rats by Maithilikarpagaselvi N1, Sridhar MG1, Swaminathan RP2, Sripradha R1, Badhe B. (PubMed)
(2) Effects of curcumin on HDL functionality by Ganjali S1, Blesso CN2, Banach M3, Pirro M4, Majeed M5, Sahebkar A. (PubMed)
Cucumber's Cucurbitacin B (CuB) Might Process Anti Diabetes Potency
Diabetes is a medical condition caused by not insufficient insulin entering the bloodstream.
In other words, diabetes is a condition associated with the inability of the body to use insulin properly.
Most cases of insulin insufficiency in the bloodstream in diabetes are either caused by the gradual died-off of the pancreas beta cells or insulin receptors clogged-up by fat and cholesterol.
Hallmarks of diabetes are hyperglycemia and insulin resistance.
According to the statistics, in 2017, 7.3% of Canadians aged 12 and older (roughly 2.3 million people) reported being diagnosed with diabetes
Most common causes of diabetes are
* Metabolic syndrome
Metabolic syndrome is a cluster of conditions including high blood pressure, cholesterol, and glucose
associated with an increased risk of diabetes.
* Gestational diabetes
High blood glucose of pregnant women has been found to increase the risk of diabetes in later life.
* Prediabetes
Most cases of prediabetes are caused by unhealthy diets with high saturated fat, smoking, and excessive alcohol drinking. Prediabetes is a high-risk state for diabetes, especially in patients who remain with prediabetes despite intensive lifestyle intervention.
* Damage to the Pancreas causes the gradual and irreversible loss of beta cells that reduce the production of insulin
* Influenza a viruses
Influenza A virus is a common cause of pancreatitis in naturally and experimentally infected animals.
However, recently, researchers found that influenza virus infection may play a role as a causative agent of pancreatitis and diabetes in humans.
* * Head trauma
Head trauma is considered a possible cause of central diabetes insipidus with symptoms of failure to concentrate urine, an increase in urine specific gravity.
The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
With an aim to find a natural compound which processes anti-diabetes property, researchers investigated the effect of different fractions of Cucumis prophetarum on antidiabetic and antioxidant activity.
The study was carried out to examine the anti-diabetes and antioxidants of the different doses of aqueous crude extract (CE) of C. prophetarum fruits fractionated into water-soluble fraction 1 (F1), chloroform fraction 2 (F2), basic fraction 3 (F3), and neutral fraction 4 (F4) by acid-base extraction,
Based on the chemical analysis,
* F1 exhibited effective antidiabetic activity with an IC50 value of 20.6 and 59.9 µg/mL.
* According to α-amylase assay, the anti-diabetes activity was found in the decreasing order of CE > F4 > F3 > F2.
* According to the DPPH assay, F1 (IC50 = 73 µg/mL) showed better reducing ability than CE >F4 >F2 > F3 (IC50 = 78-272 µg/mL
* Furthermore, according to the SO and metal chelation assays, F1 showed the highest activity anti-diabetes at the IC50 = 101 and 147 µg/mL.
These results strongly suggested that F1 possesses a potent antidiabetic compared to other fractions, in vitro.
In other words, all ingredients in cucumbers work synergistically to exhibit the anti-diabetes activity compared to a single compound.
Taken altogether, cucumber may be used for the treatment of diabetes, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antidiabetic and antioxidant potency evaluation of different fractions obtained from Cucumis prophetarum fruit by Gawli K1, Lakshmidevi N. (PubMed)
(2) Cucurbitacin B Induces Hypoglycemic Effect in Diabetic Mice by Regulation of AMP-Activated Protein Kinase Alpha and Glucagon-Like Peptide-1 via Bitter Taste Receptor Signaling by Kim KH1,2, Lee IS1,2, Park JY1,2, Kim Y1,2, An EJ1,2, Jang HJ. (PubMed)
(3) Diabetes – The Causes by Kyle J. Norton
In other words, diabetes is a condition associated with the inability of the body to use insulin properly.
Most cases of insulin insufficiency in the bloodstream in diabetes are either caused by the gradual died-off of the pancreas beta cells or insulin receptors clogged-up by fat and cholesterol.
Hallmarks of diabetes are hyperglycemia and insulin resistance.
According to the statistics, in 2017, 7.3% of Canadians aged 12 and older (roughly 2.3 million people) reported being diagnosed with diabetes
Most common causes of diabetes are
* Metabolic syndrome
Metabolic syndrome is a cluster of conditions including high blood pressure, cholesterol, and glucose
associated with an increased risk of diabetes.
* Gestational diabetes
High blood glucose of pregnant women has been found to increase the risk of diabetes in later life.
* Prediabetes
Most cases of prediabetes are caused by unhealthy diets with high saturated fat, smoking, and excessive alcohol drinking. Prediabetes is a high-risk state for diabetes, especially in patients who remain with prediabetes despite intensive lifestyle intervention.
* Damage to the Pancreas causes the gradual and irreversible loss of beta cells that reduce the production of insulin
* Influenza a viruses
Influenza A virus is a common cause of pancreatitis in naturally and experimentally infected animals.
However, recently, researchers found that influenza virus infection may play a role as a causative agent of pancreatitis and diabetes in humans.
* * Head trauma
Head trauma is considered a possible cause of central diabetes insipidus with symptoms of failure to concentrate urine, an increase in urine specific gravity.
The cucumber plant is a species of Cucumis Sativus, belongings to the family Cucurbitaceae and native to Western Asia. It is a creeping vine with roots in the ground and grows up with the support of frames.
With an aim to find a natural compound which processes anti-diabetes property, researchers investigated the effect of different fractions of Cucumis prophetarum on antidiabetic and antioxidant activity.
The study was carried out to examine the anti-diabetes and antioxidants of the different doses of aqueous crude extract (CE) of C. prophetarum fruits fractionated into water-soluble fraction 1 (F1), chloroform fraction 2 (F2), basic fraction 3 (F3), and neutral fraction 4 (F4) by acid-base extraction,
Based on the chemical analysis,
* F1 exhibited effective antidiabetic activity with an IC50 value of 20.6 and 59.9 µg/mL.
* According to α-amylase assay, the anti-diabetes activity was found in the decreasing order of CE > F4 > F3 > F2.
* According to the DPPH assay, F1 (IC50 = 73 µg/mL) showed better reducing ability than CE >F4 >F2 > F3 (IC50 = 78-272 µg/mL
* Furthermore, according to the SO and metal chelation assays, F1 showed the highest activity anti-diabetes at the IC50 = 101 and 147 µg/mL.
These results strongly suggested that F1 possesses a potent antidiabetic compared to other fractions, in vitro.
In other words, all ingredients in cucumbers work synergistically to exhibit the anti-diabetes activity compared to a single compound.
Taken altogether, cucumber may be used for the treatment of diabetes, pending to the confirmation of the larger sample size and multicenter human study.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antidiabetic and antioxidant potency evaluation of different fractions obtained from Cucumis prophetarum fruit by Gawli K1, Lakshmidevi N. (PubMed)
(2) Cucurbitacin B Induces Hypoglycemic Effect in Diabetic Mice by Regulation of AMP-Activated Protein Kinase Alpha and Glucagon-Like Peptide-1 via Bitter Taste Receptor Signaling by Kim KH1,2, Lee IS1,2, Park JY1,2, Kim Y1,2, An EJ1,2, Jang HJ. (PubMed)
(3) Diabetes – The Causes by Kyle J. Norton
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