Hyperglycemia is a condition of abnormally high levels of glucose in the bloodstream. The condition also is a hallmark of diabetes. Another hallmark is insulin resistance.
Postprandial blood glucose is the levels taken after 2 hours of a meal, generally at the approximate peak value in patients with diabetes.
Most cases of hyperglycemia are the results of poor diet and glucose management in patients with diabetes. However, missing insulin injection and improper use of insulin injection are also found in some patients.
Management of postprandial blood glucose has become an important feature for diabetics against the risk of microvascular (retinopathy, nephropathy, and neuropathy) and cardiovascular disease (CVD).
Diabetes is a medical and chronic disease characterized by insufficient insulin entering the bloodstream to regulate the glucose as a result of the cells in pancreas died off or receptor sites clogged up by fat and cholesterol.
Most common symptoms of hyperglycemia are increased thirst, headache, frequent peeing, fatigue with blood sugar more than 180 mg/dL.
Depending on the blood glucose levels, some patient may also experience symptoms of trouble concentrating, blurred vision and weight loss.
However, some researchers suggested that poor diet with high saturated and trans fat, red meat and processed foods is one of the major and preventable risk factors associated with the onset of the condition in the Western world compared to a traditional diet.
Dr. David Hefner in the concern of the risk of diabetes in patients who are fans of the Western diet wrote, "The typical Western diet-red meat, high-fat dairy products, refined grains and desserts-may increase your chances for Type 2 diabetes" and "That's what researchers at the Harvard School of Public Health have found and reported in the Annals of Internal Medicine."
The doctor continued, "The news isn't particularly shocking but offers a new view on the health risks of a typical Western diet as a whole, rather than simply attacking elements within the diet such as fatty foods".
Turmeric is a perennial plant in the genus Curcuma, belongings to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On findings a potential compound for lowering blood glucose, researchers examined the efficacy of curcumin, antihyperglycemic activity.
By searching the medical database in PubMed from 1998 to 2013, associated with the role of curcumin in the development and progression of hyperglycemia and insulin resistance, researchers found that
* Curcumin inhibited the uptakes of blood glucose level by reducing the liver glucose production and suppressing abnormally high blood sugar-induced inflammatory state.
Furthermore, stimulation of glucose uptake associated hyperglycemia caused by overexpression of GLUT4, GLUT2 and GLUT3 genes that facilitate glucose movement across cell membranes was also attenuated by curcumin.
Activation of AMP kinase and promotion of PPAR ligand-binding activity involved in stimulated glucose uptake and lipid oxidation were also reduced by the administration of the bioactive compound.
Additionally, curcumin also inhibited the expression hyperglycemia by modulating the insulin secretion from pancreatic tissues, improving pancreatic cell function, thus reducing the risk of insulin resistance.
Based on the findings, researchers wrote, "Curcumin has antihyperglycemic and insulin sensitizer effects. Thereby, more studies evaluating the effects of curcumin on hyperglycemic state and insulin resistance in related disorders such as diabetes are recommended".
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of hyperglycemia, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Phytotherapeutic activity of curcumol: Isolation, GC-MS identification, and assessing potentials against acute and subchronic hyperglycemia, tactile allodynia, and hyperalgesia by Raafat KM1, Omar AG. (PubMed)
(2) Anti-hyperglycemic and insulin sensitizer effects of turmeric and its principle constituent curcumin by Ghorbani Z1, Hekmatdoost A2, Mirmiran P. (PubMed)
(3) Western Diet Linked to Type 2 Diabetes by David Hefner. (PMC)
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