Medical Advisor Journals

Tuesday, June 21, 2016

Most Common Diseases of 50 Plus - Upper gastrointestinal disorders: Gastro-esophageal reflux disease (GERD) - The Symptoms

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Upper gastrointestinal (GI)

The prevalence of upper gastrointestinal (GI) diseases is increasing in subjects aged 65 years and over. Pathophysiological changes in esophageal functions that occur with aging may, at least in part, be responsible for the high prevalence of
1. Gastro-esophageal reflux disease (GERD) in old age.
2. The incidence of gastric and duodenal ulcers and their bleeding complications is increasing in old-aged populations worldwide.
3. H. pylori infection in elderly patients with H. pylori-associated peptic ulcer disease and severe chronic gastritis
4. Almost 40% of GU and 25% of DU in the elderly patients are associated with the use of NSAID(1) and/or aspirin(2).(a)
I. Gastro-esophageal reflux disease (GERD)
Gastroesophageal reflux disease (GERD), also known as gastro-oesophageal reflux disease (GORD), gastric reflux disease, or acid reflux disease, is defined as a chronic condition of liquid stomach acid refluxing back up from the stomach into the esophagus, causing heartburn. According to the study of “Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease.” by DeVault KR, Castell DO; American College of Gastroenterology, GERD is defined as symptoms or mucosal damage produced by the abnormal reflux of gastric contents into the esophagus.

Gastro-esophageal reflux disease (GERD)

Gastroesophageal reflux disease (GERD), also known as gastro-oesophageal reflux disease (GORD), gastric reflux disease, or acid reflux disease, is defined as a chronic condition of liquid stomach acid refluxing back up from the stomach into the esophagus, causing heartburn. According to the study of “Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease.” by DeVault KR, Castell DO; American College of Gastroenterology, GERD is defined as symptoms or mucosal damage produced by the abnormal reflux of gastric contents into the esophagus.

Symptoms

1. Heartburn
Heart burn is one of common symptom of Gastroesophageal reflux disease (GERD) in adult, as a result of acid reflux cause of burning sensation or pain in the middle of the chest mostly after meal.

2. Regurgitation
In gastroesophageal reflux disease (GERD), regurgitation is the expulsion of a small amount of digested foods to the mouth from esophagus. frequent or prolonged regurgitation can lead to acid-induced erosion of the teeth, bad breath or damage to the esophagus.

3. Trouble swallowing
It is caused by damage of the muscles and tissues that must flex for swallowing, as a result of prolonged period of acid reflux that has left untreated.

4. NauseaIt is one of uncommon of Gastroesophageal Reflux Disease (GERD), but is is associated to some people with the disease.

5. Pain when swallow
It may be caused by the damage or infection of the esophagus.

6. Asthma
In a study of The association between gastro-oesophageal reflux disease and asthma: a systematic review” by B D Havemann, C A Henderson, H B El-Serag, posted in a international journal of gastroenteroloy and hepatology, researchers found that this systematic review indicates that there is a significant association between GORD and asthma, but a paucity of data on the direction of causality.

7. Etc.

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Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/15588798
(1) http://www.ncbi.nlm.nih.gov/pubmed/16001646
(2) http://www.ncbi.nlm.nih.gov/pubmed/22542157

Food therapy - Vegetables - Green beans (Phaseolus Sensu Stricto)

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Green beans (Phaseolus Sensu Stricto)

Green bean is a genus of Phaseolus Sensu Stricto, containing 55 difference species, belong to the family Fabaceae and native to the New World tropics and grown in Europe for its attractive flowers and fleshy immature pods. It can be classified into two major groups, bush beans and pole beans.

Nutrients
1. Carbohydrates
2. Dietary fiber
3. Omega 3 Fatty Acid
4. Protein
5. Vitamin A
6. Vitamin B1
7. Vitamin B2
8. Vitamin B3
9. Folate
10. Vitamin C
11. Vitamin K
12. Magnesium
13. Tryptophan
14. Phosphorus
15. Calcium
16. Copper
17. Iron
18. Potassium
19. Etc.

Health Benefits
A. Health benefits according to studies
1. Antioxidants
in the comparison in their ability to retain vitamin C, total phenolics and antioxidative activity (DPPH and FRAP) in industrially blanched/frozen tip-cutgreen beans and swede rods found that by conventional cooking, 13.5-42.8% of the nutrients leaked into the cooking water; by sous vide about 10% leaked to the exuded liquid, while no leakage occurred by boil-in-bag cooking. Warm-holdingbeans after cooking reduced recoveries in all components. Recoveries in swede rods were comparable but overall slightly lower, according to "Vitamin C, total phenolics and antioxidative activity in tip-cut green beans (Phaseolus vulgaris) and swede rods (Brassica napus var. napobrassica) processed by methods used in catering" by Baardseth P, Bjerke F, Martinsen BK, Skrede G.(a)

2. Antiplatelet aggregation
In the investigation of the extracts from selected fruits and vegetables and theirAntiplatelet, anticoagulant, and fibrinolytic activity found that Extracts of greenbeans and tomatoes inhibited platelet aggregation induced by ADP and arachidonic acid, in a concentration-dependent manner. The methanolic extracts of grapes prolonged the PT and dPT., according to "Antiplatelet, anticoagulant, and fibrinolytic activity in vitro of extracts from selected fruits and vegetables" by Torres-Urrutia C, Guzmán L, Schmeda-Hirschmann G, Moore-Carrasco R, Alarcón M, Astudillo L, Gutierrez M, Carrasco G, Yuri JA, Aranda E, Palomo I.(b)

3. Hyperglycemia and hypertension management
In the observation of traditional corn, beans, and pumpkin and their effects on hyperglycemia and hypertension management found that further protective non-nutrient phenolic phytochemicals against NIDDM and hypertension are potentially high in these foods but less understood. In this study antidiabetic- and antihypertension-relevant potentials of phenolic phytochemicals were confirmed in select important traditional plant foods of indigenous communities such as pumpkin, beans, and maize using in vitro enzyme assays for -glucosidase, alpha-amylase, and angiotensin I-converting enzyme (ACE) inhibitory activities, according to "Health benefits of traditional corn, beans, and pumpkin: in vitro studies for hyperglycemia and hypertension management" by Kwon YI, Apostolidis E, Kim YC, Shetty K.(c)

4. Anti-diabetic and anti-hypertensive effects
In the investigation of Water-soluble extracts of soybean optimized for phenolic content via sprouting or bioprocessing by dietary fungus (Rhizopus oligosporus, Lentinus edodes) and its effect inhibitory activity against porcine pancreatic alpha-amylase (PPA), yeast alpha-glucosidase, and rabbit lung ACE found that all of the soybean extracts possessed marked anti-amylase activity, with extracts of R. oligosporus-bioprocessed soybean having the strongest inhibitory activity, but only slight anti-glucosidase activity, according to "Anti-diabetic and anti-hypertensive potential of sprouted and solid-state bioprocessed soybean" by McCue P, Kwon YI, Shetty K.(d)

5. Cardiovascular diseases
In the researches of phyto-oestrogens, isoflavones, lignans, genistein, daidzein, enterolactone, enterodiol and theirs effect on cardiovascular disease,cardiovascular disease risk factors found that Phyto-oestrogens are considered to act as selective oestrogen receptor modulators (SERM), exerting both oestrogen agonist and antagonist action. Supplementation with isolated soy protein containing the isoflavones genistein and daidzein reduces serum total and LDL-cholesterol and triglycerides in animals and in humans. Vascular reactivity might be improved by supplementation with isolated soy protein or isoflavones isolated from red clover, according to "Phyto-oestrogens and cardiovascular disease risk" by van der Schouw YT, de Kleijn MJ, Peeters PH, Grobbee DE.(e)

6. Etc.

B. Health benefits according to concentration
1. Vitamin Ca. Asthma
Vitamin C is one of the key antioxidant vitamins which is abundant in the extracellular fluid lining the lung and low vitamin C intake has been associated with pulmonary dysfunction, such as asthma, according to the study of "Vitamin Csupplementation for asthma" by Kaur B, Rowe BH, Arnold E.(I)
b. DNA Damage
Ascorbic acid (AA), known as vitamin C, has important antioxidant vitamin has exerted the activity in preventing (imazalil)IMA-induced cause of DNA damage, according to the stuyd of "The protective role of ascorbic acid on imazalil-induced genetic damage assessed by the cytogenetic tests' by Türkez H, Aydin E.(II)

2. Vitamin Ka) Bone density
A study by done by Vermeer, M H Knapen, and L J Schurger stated "it (vitamin K) was shown that administration of 1-10 mg of Vitamin K is paralleled by a moderate increase in the serum markers for bone formation (osteocalcin and bone alkaline phosphatase), or by a slight decrease in the urinary hydroxyproline exceretion ( a marker for bone resorption), and by a reduction of urinary calcium loss. Most prominent effects were obtained in fast losers of calcium."

b) Antiging
By protecting the under layer of skin membranes and stopping skin bleeding, according to the study of "Vitamin K-dependent coagulation factors deficiency" by Brenner B, Kuperman AA, Watzka M, Oldenburg J.(III)

3. Vitamin AVitamin A is not only important in preventing types I diabetes, according to "A close relationship between type 1 diabetes and vitamin A-deficiency and matrix metalloproteinase and hyaluronidase activities in skin tissues" by Takahashi N, Takasu S.(1) but also may be associated with compromised bone health, according to "Vitamins and bone health: beyond calcium and vitamin D" by Ahmadieh H, Arabi A.(IV)

4. ManganeseIt is one of important trace in preventing osteoporosis, according to the study of "[Study of estrogen deficiency impact on manganese levels in teeth and mandible of rats after ovariectomy]. [Article in Polish]" by Rahnama M, Błoniarz J, Zareba S, Swiatkowski W.(1)and regulating blood sugar level, according to the study of "[An inadequate intake of manganese may favour insulin resistance in girls]. [Article in Spanish]" by Rodríguez-Rodríguez E, Bermejo LM, López-Sobaler AM, Ortega RM.(V)

5. Dietary fiberDaily intake of right amount of fibers can prvent and treata. Diabetes, as Increased consumption of vegetables, whole grains, and soluble and insoluble fiber is associated with improved glucose metabolism in both diabetic and nondiabetic individuals. Improvements in insulin sensitivity and glucose homeostasis were more evident in participants following a plant-based diet compared with other commonly used diets, according to the study of "Efficacy of high-fiber diets in the management of type 2 diabetes mellitus" by Wolfram T, Ismail-Beigi F.(VI)

6. Etc.
C. Other health benefits
1. Immune function
Since it contains high amount of antioxidants, it improves the immune function in fighting against the forming of radicals and foreign invasion thus decreasing the risk of irregular cell growth cause of cancer, according tothe study of "Intakes of vitamins A, C and E and folate and multivitamins and lung cancer: a pooled analysis of 8 prospective studies" by Cho E, Hunter DJ, Spiegelman D, Albanes D, Beeson WL, van den Brandt PA, Colditz GA, Feskanich D, Folsom AR, Fraser GE, Freudenheim JL, Giovannucci E, Goldbohm RA, Graham S, Miller AB, Rohan TE, Sellers TA, Virtamo J, Willett WC, Smith-Warner SA.(1). Also the antioxidants vitamin C of green bean also prevents cholesterol oxidation, thus reducing the risk of heart diseases and stroke, according to the study of "Antioxidant vitamins and their use in preventing cardiovascular disease" by Farbstein D, Kozak-Blickstein A, Levy AP.(2)

3. Vitamin C
The high amounts of vitamin C, beside enhances the digestive system in absorbing vital nutrient and protects our body against acute inflammatory arthritis, according to the study of "Vitamin C intake and the risk of gout in men: a prospective study" by Choi HK, Gao X, Curhan G.(3)

4. Constipation
Since it contains high amount of fiber, it promotes large intestine in waste secretion, thus reducing the risk of constipation and colon cancer, according to the study of "Influence of dietary fiber on inflammatory bowel disease and colon cancer: importance of fermentation pattern" by Rose DJ, DeMeo MT, Keshavarzian A, Hamaker BR.(4)

5. Tryptophan
Tryptophan is an amino acid needed for normal growth in infants and for nitrogen balance in adults. It functions as a biochemical precursor for melatonin which improves the monoaminergic neurotransmission , according to the study of "Chronic melatonin treatment and its precursor L-tryptophan improve the monoaminergic neurotransmission and related behavior in the aged rat brain" Esteban S, Garau C, Aparicio S, Moranta D, Barceló P, Fiol MA, Rial R(5)

6. Etc.

Side Effects
1. Since it contains high amount of axalates, it is advised that people with kidney and gallblader disease should consult with their doctor before consuming.
2. It may reduce the absorption of calcium for some people.
3. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/20394008
(b) http://www.ncbi.nlm.nih.gov/pubmed/21311321
(c) http://www.ncbi.nlm.nih.gov/pubmed/17651062
(d) http://www.ncbi.nlm.nih.gov/pubmed/15927931
(e) http://www.ncbi.nlm.nih.gov/pubmed/11006924

(I) http://www.ncbi.nlm.nih.gov/pubmed/19160185
(II) http://www.ncbi.nlm.nih.gov/pubmed/21986888
(III) http://www.ncbi.nlm.nih.gov/pubmed/19598072
(IV) http://www.ncbi.nlm.nih.gov/pubmed/21967159
(V) http://www.ncbi.nlm.nih.gov/pubmed/22072339
(VI) http://www.ncbi.nlm.nih.gov/pubmed/20713332

(1) http://www.ncbi.nlm.nih.gov/pubmed/16152626
(2) http://www.ncbi.nlm.nih.gov/pubmed/21063272
(3) http://www.ncbi.nlm.nih.gov/pubmed/19273781
(4) http://www.ncbi.nlm.nih.gov/pubmed/17345958
(5) http://www.ncbi.nlm.nih.gov/pubmed/20082664

Traditional Chinese Medicine Herbal Therapy - Popular Chinese Herbs - Chuan Lian or Huang Lian (Rhizoma Coptidis)

2. Antineoplastic effect
In the review of the pharmacological studies of huanglian and berberine, with an emphasis on their antineoplastic effects and the promise as novel antineoplastic agents, found that Berberine is an essential anticancer compound in huanglian. In some studies, the use of huanglian was shown to be more effective and beneficial than the use of berberine alone. The presence of other protoberberine-type alkaloids in huanglian might give synergistic effects for the anticancer effects. Berberine also demonstrates effects of antiangiogenesis, anti-invasion and anti-metastasis in some cancer cell lines, however, more investigations are required to unravel the underlying mechanisms involved, according to “Berberine and Coptidis rhizoma as novel antineoplastic agents: a review of traditional use and biomedical investigations” by Tang J, Feng Y, Tsao S, Wang N, Curtain R, Wang Y.(2).

3. Hepatoprotective effect
In the demonstration of Coptidis rhizoma aqueous extract (CRAE) antioxidant effects against CCl(4)-induced acute liver, found that CRAE showed protective effect against CCl(4)-induced chronic liver damage in rats and its potential as an agent in the treatment of chronic liver diseases by protecting hepatocyte from injury, according to “Hepatoprotective effect and its possible mechanism of Coptidis rhizoma aqueous extract on carbon tetrachloride-induced chronic liver hepatotoxicity in rats” byFeng Y, Wang N, Ye X, Li H, Feng Y, Cheung F, Nagamatsu T.(3).

4. Type II diabetes
In the evaluation of the effects of different compatibility proportion of Jiaotai pills on treating type 2 diabetes mellitus (T2DM) in rats by injecting streptozotocin from tail vein and feeding with high fat and high caloric diet. Diabetic rats were randomly divided into model group, Jiaotai pill 1 group (Coptidis Rhizoma-cinnamon 2: 1), Jiaotai pill 2 group (Coptidis Rhizoma-cinnamon 4: 1), Jiaotai pill 3 group (Coptidis Rhizoma-cinnamon 10: 1) and metformin group, found that different compatibility proportion of Jiaotai pills are effective on treating type 2 diabetes mellitus in rats. The effect of Jiaotai pill 1 group is better than that of other therapy groups, according to “[Effects of different compatibility proportion of jiaotai pills on treating type 2 diabetes mellitus in rats].[Article in Chinese]” by Wang J, Lu F, Dong H, Gong Y, Xu L, Zou X, Chen G.(4).

5. Neuroprotective effect
In the To examination of whether berberine has survival promoting effect on damaged neuronal cells, found that berberine promotes activity dependent cell survival mediated by NMDA receptor because berberine is known to activate neurons by blocking K(+) current or lowering the threshold of the action potential. Taken together, berberine has neuroprotective effect on damaged neurons and neurodegenerating brains of neonatal animal model induced by MK-801 administration, according to “Effect of Berberine on Cell Survival in the Developing Rat Brain Damaged by MK-801″ by Lee T, Heo H, Kim Kwon Y.(5).

6. Hepatitis C virus
In the investigation of San-Huang-Xie-Xin-Tang (SHXT), a transitional Chinese herbal formula, composed of Rhei rhizoma, Scutellaria radix and Coptidis rhizome, and possesses anti-inflammatory effect, found that SHXT-frC treatment also caused a concentration-dependent decrease in the induction of COX-2 and NF-κB expression caused by either HCV replication or HCV NS5A protein. Collectively, SHXT-frC could be an adjuvant treatment for patients with HCV-induced liver diseases, according to “San-Huang-Xie-Xin-Tang extract suppresses hepatitis C virus replication and virus-induced cyclooxygenase-2 expression”by Lee JC, Tseng CK, Wu SF, Chang FR, Chiu CC, Wu YC.(6).

7. Rheumatoid arthritis
In the evaluation of Berberine, the major constituent of Coptidis Rhizoma, widely used as an antitumor and anti-inflammation agent for its effect on the progression of rheumatoid arthritis (RA), found that berberine exerts antiproliferative effects against RAFLSs, likely through deregulation of numerous cell cycle and apoptosis regulators, thus having potential therapeutic implications in the treatment of RA, according to “Effects of berberine on human rheumatoid arthritis fibroblast-like synoviocytes”byWang XH, Jiang SM, Sun QW.(7).

8. Irritable bowel syndrome
In the examination of the effect of CR extract on neonatal maternal separation (NMS)-induced visceral hyperalgesia in rats and its underlying action mechanisms, found that electromyogram (EMG) signals in response to colonic distension were measured with the NMS rats showing lower pain threshold and increased EMG activity than those of the unseparated (N) rats. CR dose-dependently increased pain threshold response and attenuated EMG activity in the NMS rats. An enzymatic immunoassay study showed that CR treatment significantly reduced the serotonin (5HT) concentration from the distal colon of NMS rats compared to the Veh (control) group, according to “Analgesic effect of Coptis chinensis rhizomes (Coptidis Rhizoma) extract on rat model of irritable bowel syndrome” by Tjong Y, Ip S, Lao L, Fong HH, Sung JJ, Berman B, Che C.(8).

9. Oropharyngeal candidiasis
In the searching for alternativecandidiasis treatment among individuals infected with HIV, as 90% of patients develop oral and/or oropharyngeal candidiasis in various stages of AIDS.
found that traditional Chinese medicinal herbs provide abundant choices for the treatment of refractory candidiasis commonly seen in HIV/AIDS patients. However, there remains a need for further screening of effective extracts and for study of the antifungal mechanisms involved. Importantly, ahead of clinical application, the safety of these compounds must be firmly established, according to “Effect of traditional Chinese medicinal herbs on Candida spp. from patients with HIV/AIDS” by Liu X, Han Y, Peng K, Liu Y, Li J, Liu H.(9).

10. Anti-inflammatory effects
In the study of Huang-Lian-Jie-Du decoction (HLJDD) (Oren-gedoku-to in Japanese) as a famous traditional Chinese recipe is composed of Rhizoma coptidis, Radix scutellariae, Cortex phellodendri and Fructus gardeniae, used to treat inflammation for nearly two thousand years, found that with the help of principal component analysis (PCA) technique, the data obtained revealed that the two fractions and the major group of compounds in HLJDD (iridoids, flavonoids and alkaloids) complement each other with particular emphasis to synergistically exert anti-inflammatory effects, according to “Anti-inflammatory effects of Huang-Lian-Jie-Du decoction, its two fractions and four typical compounds” by Lu J, Wang JS, Kong LY.(10).

11. Coptidis rhizoma and Diabetes
In the study of berberine in the control of blood glucose and lipid and metabolism disorders, indicated that berberine, an isoquinoline alkaloid isolated from some Chinese medicinal herbs such as Coptidis rhizoma found that the mechanisms involve many aspects of the diabetes, including regulating the blood cholesterol and triglyceride, lowering blood glucose, ameliorating the insulin resistant state and influencing the function of the pancreatic beta cell, according to “[Advances of the mechanism study on berberine in the control of blood glucose and lipid as well as metabolism disorders].[Article in Chinese]” by Shen N, Li CN, Huan Y, Shen ZF.(11).

Obesity and Obesity's complication - The association of Obesity on Skin Diseases

Skin infection is defined as a condition of infection of skin caused by certain bacteria, including Impetigo (a highly contagious bacterial skin infection), Erysipelas (an acute streptococcus bacterial infection), Cellulitis (a diffuse inflammation, etc. ,fungal skin infections of the skin, hair, and/or nails, parasitic infestations and viral related infections

The association of Obesity on Skin Diseases
1. According to the study of "Skin manifestations of obesity: a comparative study" by Boza JC, Trindade EN, Peruzzo J, Sachett L, Rech L, Cestari TF.(Source from Department of Dermatology, Federal University of Rio Grande do Sul (UFRGS), Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre, Brazil, © 2011 The Authors. Journal of the European Academy of Dermatology and Venereology © 2011 European Academy of Dermatology and Venereology), posted in PubMed, researchers concluded that Obesity is strongly related to several skinalterations that could be considered as markers of excessive weight. Skin care of obese patients deserves particular attention, not only because of the high prevalence of cutaneous alteration but mainly because many of these disorders are preventable and could be treated, improving patient's quality of life.

2. In the abstract of the study of " The impact of obesity on skin disease and epidermal permeability barrier status" by Guida B, Nino M, Perrino NR, Laccetti R, Trio R, Labella S, Balato N. (Source from Department of Neuroscience, Physiology Nutrition Unit, University Federico II, Naples, Italy. bguida@unina.it, J Eur Acad Dermatol Venereol. 2010 Feb;24(2):191-5. Epub 2009 Nov 19), posted in PubMed. researchers found that Specific dermatoses as skin tags, striae distensae and plantar hyperkeratosis, could be considered as a cutaneous stigma of severe obesity. The low permeability of the skin to evaporative water loss is observed in obese subjects compared with normal weight control. Although the physiological mechanisms are still unknown, this finding has not been previously described and we believe that this may constitute a new field in the research onobesity.

3. In a study of "The influence of body mass index on skin susceptibility to sodium lauryl sulphate" by Löffler H, Aramaki JU, Effendy I. (Source from Department of Dermatology, University of Marburg, Germany. Harald.Loeffler@mailer.uni-marburg.de, Skin Res Technol. 2002 Feb;8(1):19-22.), posted in PubMed, researchers indicated that Basal biophysical parameters of theskin are primarily correlated with the BMI. This may be caused by obesity-induced physiological changes, e.g. increased sweat gland activity, high blood pressure and physiological temperature-regulating system. The epidermal barrier function, as evaluated after SLS patch testing is, however, not correlated with a high BMI, indicating a normal skin barrier.

4. In a study of "An overview of dermatological conditions commonly associated with the obese patient" by Hahler B. (Source from St. Vincent Mercy Medical Center, 2213 Cherry Street, Toledo, OH 43608, USA. hahlb@buckeye-access.com, Ostomy Wound Manage. 2006 Jun;52(6):34-6, 38, 40 passim), posted in PubMed, researchers found that with the continuing increase in the incidence of obesity, investigation into the specific care needs of this population is needed. In clinical practice, measures to reduce friction and shear and improve devices to move the obese patient would enhance care provision. Studies of the incidence of dermatological problems and the best treatments for these conditions are warranted.

5. Etc.

Treatments of Obesity and Skin Diseases
1. In a study of "[Skin manifestations, treatment and rehabilitation in overweight and obesity].

[Article in Hungarian] by Wenczl E. (Source from Fovárosi Onkormányzat Egyesített Szent István és Szent László Kórház és Rendelointézet Borgyógyászati és Lymphológiai Rehabilitációs Osztály Budapest Nagyvárad tér 1. 1095, Orv Hetil. 2009 Sep 13;150(37):1731-8), researchers found that Draw patients' attention to the preventive importance of skin care. In case of an obese patient the usual dosage of most local and systemic drugs should be modified. It must be kept in mind that obesity directly or indirectly starts unfavorable processes in almost all organ systems. Therefore, only a multidisciplinary care may secure treatment and rehabilitation of obese patients. Dermatological and lymphological care is often part of the rehabilitation.

2. According to the study of "Dermatological complications of obesity" by García Hidalgo L. (Source from Department of Dermatology, Salvador Zubiran National Nutrition Institute, Mexico City, Mexico. lindagh@avantel.net, Am J Clin Dermatol. 2002;3(7):497-506.), posted in PubMed, researchers found that Excess load on the feet can result in morphological changes that require careful diagnosis; insoles may offer some symptom relief while control of obesity is achieved.Obesity-related dermatoses associated with hospitalization, such as pressure ulcers, diminished wound healing, dermatoses secondary to respiratory conditions, and incontinence, must all be carefully managed with an emphasis on prevention where possible. Recognition and control of the dermatological complications ofobesity play an important role in diminishing the morbidity of obesity.

3. In an abstract of the studt of "Obesity and the skin: skin physiology and skinmanifestations of obesity" by Yosipovitch G, DeVore A, Dawn A. (Source from Departments of Dermatology, Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. gyosipov@wfubmc.edu, J Am Acad Dermatol. 2007 Jun;56(6):901-16; quiz 917-20.) posyed in PubMed, researchers indicated that evidence for association with obesity, and management of these various dermatoses and highlight the profound impact of obesity in clinical dermatology. LEARNING OBJECTIVE: After completing this learning activity, participants should be aware of obesity-associated changes in skin physiology,skin manifestations of obesity, and dermatologic diseases aggravated by obesity, and be able to formulate a pathophysiology-based treatment strategy for obesity-associated dermatoses.

4. Etc.

Chinese Food Therapy
The Best Way to prevent, treat your disease, including Obesity
and restore your health naturally with Chinese diet

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer

The Holistic prevention, management and treatment of Polycystic Ovarian Syndrome: The Stress Response and Management herbal Schisandra

Polycystic Ovarian Syndrome is defined as endocrinologic diseases among reproductive-age women caused by undeveloped follicles clumping on the ovaries that interferes with the function of the normal ovaries associated with a high risk for metabolic disorder(1) as resulting of enlarged ovaries(2), leading to hormone imbalance(excessive androgen and anti-müllerian hormone (AMH) )(1)(3)(4)(5), induced Hirsutism(6)(7), reproductive disorder(10(12)), risks of type 2 diabetes(9)(10)(11), metabolic syndrome(10)(12) and early cardiovascular disease(8)(13), acne(10)(14), endometrial cancer(18)(19),weight gain and obesity(15)(16)(17). The syndrome effects over 5% of women population or 1 in 20 women.
Unfortunately, according to studies, women with PCOs after the reproductive age, are associated to continuously increase risk of type II diabetes, with no increasingaltered glucose tolerance(20), CVD and hypertension(21).

The prevention and management In Herbal Medicine

Polycystic ovary syndrome (PCOS) is unpreventable in Western medicine. Early diagnosis and treatment may reduce risk of its complications, including infertility, metabolic syndrome, obesity, diabetes, cardiovascular diseases, stroke, etc.
Reduce fat intake less than 30% of total calories with a low proportion of saturated fat and high in fiber from predominantly low-glycaemic-index-carbohydrate foods for patients with PCOs(827a). Calorie intake should be distributed between several meals per day with restricted intake of snacks and drinks(828).

The stress management herbs

Stress in a natural reaction of human fight or fight response induced by pressure due to such as an environmental condition or a stimulus. Long term stress can cause deleterious and cumulative effects on human body(1104), including emotional or cognitive problems, such as an increased risk of attentional deficit/hyperactivity, anxiety, and language delay(1103), especially for people with chronic illness, including women with Polycystic Ovarian Syndrome (PCOs)(1105).

Schisandra (Wu Wei Zi)

Schisandra also is known as Wu Wei Zi, a twining shrub living its life by climbing on other vegetation, belongings to the family Schisandraceae, native to Asia and North America, The warm, sweet, bitter, sour, acrid, salty herb has been used in tradional Chinese medicine as antioxidant(1218)(1219), anti stress(1220)(1221), anti microbial(1224)(1225)(1226) agent and to improve metabolism(1227)(1228), enhance central nervous system(1229)(1230)(1233), treat hypertension(1231)(1232) and hypotension during exhaustion of circulatory function(1217), coughing(1234)(12135), insomnia(1237), premenstrual syndrome (PMS)(1239), menopausal symptoms(1240), depression(1233), irritability(1233), erectile dysfunction (ED)(1238), lower cholesterol(1241) and regulate blood glucose(1233), improve memory(1222)(1223), etc.
by promoting function of lung and kidney channels(1217).

Phytochemicals(1217)
1. Schizandrin
2. Deoxyschisandrin
3. Gamma-schisandrin
4. Schisandrol
5. Pseudo-gamma-schisandrin
6. Schizandrate B
7. Gomisin A, B, C, F, G
8. Angeloylgomisin H
9. Tigloylgomisin H
10. Benzoylgomisin H
11. Epigomisin O
12. Malic acid
13. Citric acid
14. Tartaric acid
15. Succinic acid
16. A-pinene
17. Camphene
18. B-pinene
19. Byrcene
20. A-terpinene
21. Limonene
22. G-terpinene
23. P-cymene
24. Etc.

In chronic psychological stress male rat model, schisandra protect against stress induced complications such as carbohydrate metabolism(1227) and neurosis, psychogenic depression, astheno-depressive states, schizophrenia and alcoholism disorders(1233) and improved mental performance(1233).through its reduction of the levels of corticosterone (CORT) and glucose and protect the structure of the adrenal cortex(1227).
In physiological stress, the herbal medicine also exerted its stress-protective effect against a broad spectrum of harmful factors including heat shock, skin burn, cooling, frostbite, immobilisation, swimming under load in an atmosphere with decreased air pressure, aseptic inflammation, irradiation, and heavy metal intoxication(1233).
In oxidative stress induced damage heart(1242) tissues in animal models, schisandrin B (Sch B), a dibenzocyclooctadiene derivative isolated from the fruit of Schisandra chinensis attenuated cardiotoxicity via antioxidant and anti-inflammatory effects(1242). In oxidative stress induced liver damage, oral administration of Schisandra Lignans Extract (SLE)(1243)(1244) or triterpenoid(1245) a chemical constituent from Schisandra chinensis significantly reduced liver damage(1243)(1244)(1245) in experimental animal model, through its effects of balance of oxidation and reduction in cells(1243) or upregulating cell cycle progression(1244) and anti tumor antigen(1244), or ameliorating oxidative stress(1245).

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References
(1) Adiposity and metabolic dysfunction in polycystic ovary syndrome by Sam S.(PubMed)
(2) A "kiss" before conception: triggering ovulation with kisspeptin-54 may improve IVF by Young SL.(PubMed)
(3.) Androgen hyperfunction and excessive heterosexual hair growth in women, with special attention to the polycystic ovarian syndrome by Lunde O1.(PubMed)
(4) Expression of anti-Müllerian hormone in letrozole rat model of polycystic ovary syndrome by Du DF1, Li XL, Fang F, Du MR.(PubMed)
(5) [Serum levels of anti-muller hormone in women with polycystic ovary syndromeand healthy women of reproductive age].[Article in Bulgarian] by Parahuleva N, Pehlivanov B, Orbecova M, Deneva T, Uchikova E.(PubMed)
(6) [Current opinions on the etiology and pathophysiology of hirsutism].[Article in Polish] by Krysiak R1, Kedzia A, Okopień B.(PubMed)
(7) The clinical evaluation of hirsutism by Somani N1, Harrison S, Bergfeld WF.(PubMed)
(8) Polycystic ovary syndrome and insulin: our understanding in the past, present and future by Mayer SB1, Evans WS, Nestler JE.(PubMed)
(9) Association of mean platelet volume with androgens and insulin resistance in nonobese patients with polycystic ovary syndrome by Dogan BA1, Arduc A2, Tuna MM1, Karakılıc E1, Dagdelen I1, Tutuncu Y1, Berker D1, Guler S1.(PubMed)
(10) Approach to the patient: contraception in women with polycystic ovary syndrome by Yildiz BO1.(PubMed)
(11) Polycystic ovarian syndrome (PCOS): a significant contributor to the overall burden of type 2 diabetes in women by Talbott EO1, Zborowski JV, Rager JR, Kip KE, Xu X, Orchard TJ.(PubMed)
(12) Prevalence of vitamin D deficiency in Slovak women with polycystic ovary syndrome and its relation to metabolic and reproductive abnormalities by Figurová J1, Dravecká I, Javorský M, Petríková J, Lazúrová I.(PubMed)
(13) Role of Insulin Sensitizers on Cardiovascular Risk Factors in Polycystic Ovarian Syndrome: A Meta-Analysis by Thethi TK1, Katalenich B2, Nagireddy P3, Chabbra P4, Kuhadiya N5, Fonseca V1.(PubMed)
(14) Acne in hirsute women by Lumezi BG1, Pupovci HL1, Berisha VL1, Goçi AU2, Gerqari A3.(PubMed)
(15) Obesity and polycystic ovary syndrome by Naderpoor N1, Shorakae S, Joham A, Boyle J, De Courten B, Teede HJ.(PubMed)
(16) Polycystic ovary syndrome: a complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan by Teede H1, Deeks A, Moran L.(PubMed)
(17) Metabolic Evidence of Diminished Lipid Oxidation in Women With Polycystic Ovary Syndrome. by Whigham LD1, Butz DE2, Dashti H3, Tonelli M3, Johnson LK1, Cook ME2, Porter WP4, Eghbalnia HR5, Markley JL6, Lindheim SR7, Schoeller DA8, Abbott DH9, Assadi-Porter FM10.(PubMed)
(18) Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis by Barry JA1, Azizia MM1, Hardiman PJ2.(PubMed)
(19) Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study by Gottschau M1, Kjaer SK2, Jensen A1, Munk C1, Mellemkjaer L3.(PubMed)
(20) Polycystic ovary syndrome: metabolic consequences and long-term management by Carmina E1.(PubMed)
(21) Arterial stiffness is increased in asymptomatic nondiabetic postmenopausal women with a polycystic ovary syndrome phenotype by Armeni E1, Stamatelopoulos K, Rizos D, Georgiopoulos G, Kazani M, Kazani A, Kolyviras A, Stellos K, Panoulis K, Alexandrou A, Creatsa M, Papamichael C, Lambrinoudaki I.(PubMed)
(827a) Diet and nutrition in polycystic ovary syndrome (PCOS): pointers for nutritional management by Farshchi H, Rane A, Love A, Kennedy RL(PubMed)
(828) The optimal diet for women with polycystic ovary syndrome? by Marsh K, Brand-Miller J.(PubMed) (1106) Simultaneous Estimation of Withaferin A and Z-Guggulsterone in Marketed Formulation by RP-HPLC by Agrawal P1, Vegda R2, Laddha K2.(PubMed)

(1217) Wu Wei Zi(Complementary and Alternative Healing University)
(1218) Antioxidant and hepatoprotective effects of Schisandra chinensis pollen extract on CCl4-induced acute liver damage in mice by Cheng N1, Ren N, Gao H, Lei X, Zheng J, Cao W.(PubMed)
(1219) Schizandrin, an antioxidant lignan from Schisandra chinensis, ameliorates Aβ1-42-induced memory impairment in mice by Hu D1, Cao Y, He R, Han N, Liu Z, Miao L, Yin J.(PubMed)
(1220) Schisantherin A recovers Aβ-induced neurodegeneration with cognitive decline in mice by Li X1, Zhao X1, Xu X1, Mao X1, Liu Z1, Li H1, Guo L1, Bi K2, Jia Y3.(PubMed)
(1221) Schisandrin B prevents doxorubicin induced cardiac dysfunction by modulation of DNA damage, oxidative stress and inflammation through inhibition of MAPK/p53 signaling by Thandavarayan RA1, Giridharan VV2, Arumugam S3, Suzuki K4, Ko KM5, Krishnamurthy P6, Watanabe K3, Konishi T7.(PubMed)
(1222) Schizandrin, an antioxidant lignan from Schisandra chinensis, ameliorates Aβ1-42-induced memory impairment in mice by Hu D1, Cao Y, He R, Han N, Liu Z, Miao L, Yin J.(PubMed)
(1223) Deoxyschizandrin isolated from the fruits of Schisandra chinensis ameliorates Aβ₁₋₄₂-induced memory impairment in mice by Hu D1, Li C, Han N, Miao L, Wang D, Liu Z, Wang H, Yin J.(PubMed)
(1224) A comparison of the anti-Staphylococcus aureus activity of extracts from commonly used medicinal plants by Snowden R1, Harrington H, Morrill K, Jeane L, Garrity J, Orian M, Lopez E, Rezaie S, Hassberger K, Familoni D, Moore J, Virdee K, Albornoz-Sanchez L, Walker M, Cavins J, Russell T, Guse E, Reker M, Tschudy O, Wolf J, True T, Ukaegbu O, Ahaghotu E, Jones A, Polanco S, Rochon Y, Waters R, Langland J.(PubMed)
(1225) Anti-HIV-1 activity of lignans from the fruits of Schisandra rubriflora by Xiao WL1, Wang RR, Zhao W, Tian RR, Shang SZ, Yang LM, Yang JH, Pu JX, Zheng YT, Sun HD.(PubMed)
(1226) Compositions and biological activities of essential oils of Kadsura longepedunculata and Schisandra sphenanthera by Song L1, Ding JY, Tang C, Yin CH.(PubMed)
(1227) [Effects of schisandra on the function of the pituitary-adrenal cortex, gonadal axis and carbohydrate metabolism in rats undergoing experimental chronic psychological stress, navigation and strenuous exercise].[Article in Chinese] by Sun LJ1, Wang GH, Wu B, Wang J, Wang Q, Hu LP, Shao JQ, Wang YT, Li J, Gu P, Lu B.(PubMed)
(1228) In vivo to in vitro effects of six bioactive lignans of Wuzhi tablet (Schisandra sphenanthera extract) on the CYP3A/P-glycoprotein-mediated absorption and metabolism of tacrolimus by Qin XL1, Chen X, Wang Y, Xue XP, Wang Y, Li JL, Wang XD, Zhong GP, Wang CX, Yang H, Huang M, Bi HC.(PubMed)
(1229) The effects of lignan-riched extract of Shisandra chinensis on amyloid-β-induced cognitive impairment and neurotoxicity in the cortex and hippocampus of mouse by Jeong EJ1, Lee HK, Lee KY, Jeon BJ, Kim DH, Park JH, Song JH, Huh J, Lee JH, Sung SH.(PubMed)
(1230) Schisandrin B exerts anti-neuroinflammatory activity by inhibiting the Toll-like receptor 4-dependent MyD88/IKK/NF-κB signaling pathway in lipopolysaccharide-induced microglia by Zeng KW1, Zhang T, Fu H, Liu GX, Wang XM.(PubMed)
(1231) Preventive effect of gomisin J from Schisandra chinensis on angiotensin II-induced hypertension via an increased nitric oxide bioavailability by Ye BH1, Lee SJ1, Choi YW2, Park SY1, Kim CD1.(PubMed)
(1232) Antihypertensive effect of gomisin A from Schisandra chinensis on angiotensin II-induced hypertension via preservation of nitric oxide bioavailability by Young Park J1, Wook Yun J, Whan Choi Y, Ung Bae J, Won Seo K, Jin Lee S, Youn Park S, Whan Hong K, Kim CD.(PubMed)
(1233) Pharmacology of Schisandra chinensis Bail.: an overview of Russian research and uses in medicine by Panossian A1, Wikman G.(PubMed)
(1234) Effects of Schisandra chinensis extracts on cough and pulmonary inflammation in a cough hypersensitivity guinea pig model induced by cigarette smoke exposure by Zhong S1, Nie YC1, Gan ZY1, Liu XD1, Fang ZF1, Zhong BN1, Tian J1, Huang CQ1, Lai KF2, Zhong NS1.(PubMed)
(1235) Effects of the Schisandra fructus water extract on cytokine release from a human mast cell line. by Kang OH1, Chae HS, Choi JH, Choi HJ, Park PS, Cho SH, Lee GH, So HY, Choo YK, Kweon OH, Kwon DY.(PubMed)
(1236) [Effects of extracts from ziziphi spinosae semen and schisandrae chinensis fructus on amino acid neurotransmitter in rats with insomnia induced by PCPA].[Article in Chinese] by Gao JR, Ji WB, Jiang H, Chen JF.(PubMed)
(1237) Gomisin N isolated from Schisandra chinensis augments pentobarbital-induced sleep behaviors through the modification of the serotonergic and GABAergic system by Zhang C1, Mao X1, Zhao X1, Liu Z1, Liu B1, Li H1, Bi K2, Jia Y3.(PubMed)
(1238) Panax ginseng, Rhodiola rosea and Schisandra chinensis by Chan SW1.(PubMed)
(1239) Herbal composition for promoting hormonal balance in women and methods of using same US 6242012 B1
(1240) The mechanism of vasorelaxation induced by Schisandra chinensis extract in rat thoracic aorta by Park JY1, Shin HK, Lee YJ, Choi YW, Bae SS, Kim CD.(PubMed)
(1241) Shengmai San reduces hepatic lipids and lipid peroxidation in rats fed on a high-cholesterol diet by Yao HT1, Chang YW, Chen CT, Chiang MT, Chang L, Yeh TK.(PubMed)
(1242) Schisandrin B prevents doxorubicin induced cardiac dysfunction by modulation of DNA damage, oxidative stress and inflammation through inhibition of MAPK/p53 signaling by Thandavarayan RA1, Giridharan VV2, Arumugam S3, Suzuki K4, Ko KM5, Krishnamurthy P6, Watanabe K3, Konishi T7.(PubMed)
(1243) Schisandra Lignans Was Related with Its Antioxidative Actions in Liver Cells by Pu HJ1, Cao YF, He RR, Zhao ZL, Song JH, Jiang B, Huang T, Tang SH, Lu JM, Kurihara H.(PubMed)
(1244) Therapeutic efficacy of Wuzhi tablet (Schisandra sphenanthera Extract) on acetaminophen-induced hepatotoxicity through a mechanism distinct from N-acetylcysteine by Fan X1, Chen P1, Jiang Y1, Wang Y1, Tan H1, Zeng H1, Wang Y1, Qu A1, Gonzalez FJ1, Huang M1, Bi H2.(PubMed)
(1245) Effects of triterpenoid from Schisandra chinensis on oxidative stress in alcohol-induced liver injury in rats by Li B1, Zhu L, Wu T, Zhang J, Jiao X, Liu X, Wang Y, Meng X.(PubMed)

The Smoothie of Green Tea, Blueberry, Peanut and Curcumin for Reduced Risk and Treatment of Systemic lupus erythematosus (SLE)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for prevention and treatment of Systemic lupus erythematosus (SLE)
Yield: 2 servings (about 8 ounces each)
1 1/ 4 cups Blueberry
1/4 cup peanut
1/4 tsp curcumin(optional)
1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of Systemic lupus erythematosus (SLE) has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Systemic lupus erythematosus (SLE) or Lupus is a chronic, autoimmune disease as a result of the development of autoantibodies attacked the systems and organs in the body, causing caspase-1, IL-1β and IL-18 production(9).

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. According to Kyushu University, chronic drinking of tea may attenuate the risk of Systemic lupus erythematosus (SLE)(1)

Major phytochemical constituent isolated from green tea, in National Defense Medical Center study, expressed the prophylactic effects on lupus nephritis in prevented proteinuria, renal function impairment, and severe renal lesions through antioxidant and free radical scavenging and anti pro inflammatory activities(2).

Furthermore, the antioxidant also manifested the cisplatin-induced nephrotoxicity is associated with increased oxidative stress and inflammatory cytokines in the kidney, including inhibiting NF-kappaB, the pro inflammatory pathway(3).

Resveratrol is a phytochemical in the class of Stilbenoids, found abundantly in grape, blueberry and peanuts, may also display anti Minimal mesangial glomerulonephritis induced by Systemic lupus erythematosus (SLE) through its immune-modulated effects(5). According to the joint study led by the Peking Union Medical College and Chinese Academy of Medical Sciences, resveratrol exhibited protective effects in pristane-induced lupus mice via anti-inflammation and immune-regulatory properties(4).

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia. The herb has been used in trditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc. its chemical constituent curcumin exhibited anti SLE effects through maintaining the balance between T helper 17 (Th17) and regulatory T cells (Treg)(6).
According to the University of Chicago, curcumin increased the expression of IgG deposits in protection against altered the transport of immune complexes leading to an increase in IgG deposits which could induce inflammatory pathways thereby leading to worsening of the disease(7).

Furthermore, oral administration of turmeric supplementation can decrease proteinuria, hematuria, and systolic blood pressure in patients suffering from relapsing or refractory lupus nephritis, the Shiraz University of Medical Sciences suggested(8).

The smoothie of Green Tea, Blueberry, Peanut and Curcumin may hold a key in further studies in production of effective natural ingredients for prevention and treatment of Systemic lupus erythematosus (SLE) without inducing adverse effects.

People who are at increased risk of any of Systemic lupus erythematosus (SLE)due to family history, weaken immunity... should drink at least one cup daily. People with Systemic lupus erythematosus (SLE), should drink no more than 4 servings daily, depending to the digestive toleration.

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References

(1) Modifying effect of N-acetyltransferase 2 genotype on the association between systemic lupus erythematosusand consumption of alcohol and caffeine-rich beverages by Kiyohara C1, Washio M, Horiuchi T, Asami T, Ide S, Atsumi T, Kobashi G, Takahashi H, Tada Y; Kyushu Sapporo SLE (KYSS) Study Group.(PubMed)

(2) Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation by Tsai PY1, Ka SM, Chang JM, Chen HC, Shui HA, Li CY, Hua KF, Chang WL, Huang JJ, Yang SS, Chen A.(PubMed)

(3) Epigallocatechin-3-gallate activates Nrf2/HO-1 signaling pathway in cisplatin-induced nephrotoxicity in rats by Sahin K1, Tuzcu M, Gencoglu H, Dogukan A, Timurkan M, Sahin N, Aslan A, Kucuk O.(PubMed)

(4) Resveratrol possesses protective effects in a pristane-induced lupus mouse model by Wang ZL1, Luo XF1, Li MT1, Xu D1, Zhou S1, Chen HZ2, Gao N1, Chen Z1, Zhang LL1, Zeng XF1.(PubMed)

(5) [Effect of resveratrol on the activation of murine CD4(+);T lymphocytes].[Article in Chinese]by Wang Z1, Zeng X, Li M, Luo X.(PubMed)

(6) Treatment of low doses curcumin could modulate Th17/Treg balance specifically on CD4+ T cell cultures ofsystemic lupus erythematosus patients by Handono K1, Pratama MZ2, Endharti AT3, Kalim H2.(PubMed)

(7) Curcumin aggravates CNS pathology in experimental systemic lupus erythematosus by Foxley S1, Zamora M, Hack B, Alexander RR, Roman B, Quigg RJ, Alexander JJ.(PubMed)

(8) Oral supplementation of turmeric decreases proteinuria, hematuria, and systolic blood pressure in patients suffering from relapsing or refractory lupus nephritis: a randomized and placebo-controlled study by Khajehdehi P1, Zanjaninejad B, Aflaki E, Nazarinia M, Azad F, Malekmakan L,Dehghanzadeh GR.(PubMed)
(9) Phytochemicals against lupus by Kyle J. Norton