Tuesday, June 21, 2016

The Smoothie of Green Tea, Blueberry, Peanut and Curcumin for Reduced Risk and Treatment of Systemic lupus erythematosus (SLE)

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for prevention and treatment of Systemic lupus erythematosus (SLE)
Yield: 2 servings (about 8 ounces each)
1 1/ 4 cups Blueberry
1/4 cup peanut
1/4 tsp curcumin(optional)
1 cup green tea drink (Make from 4 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for treatment of Systemic lupus erythematosus (SLE)  has been running into many obstacles, many ingredients showed initially with promising result in animal studies have not produced same potentials in large sample size and mutli centers human trials.

Systemic lupus erythematosus (SLE) or Lupus is a chronic, autoimmune disease as a result of the development of autoantibodies attacked  the systems and organs in the body, causing caspase-1, IL-1β and IL-18 production(9).

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. According to Kyushu University, chronic drinking of tea may attenuate the risk of Systemic lupus erythematosus (SLE)(1)
Major phytochemical constituent isolated from green tea, in National Defense Medical Center study, expressed the prophylactic effects on lupus nephritis in prevented proteinuria, renal function impairment, and severe renal lesions through antioxidant and free radical scavenging and anti pro inflammatory activities(2).
Furthermore, the antioxidant also manifested the cisplatin-induced nephrotoxicity is associated with increased oxidative stress and inflammatory cytokines in the kidney, including inhibiting NF-kappaB, the pro inflammatory pathway(3).

Resveratrol is a phytochemical in the class of Stilbenoids, found abundantly in grape, blueberry and peanuts, may also display anti Minimal mesangial glomerulonephritis induced by Systemic lupus erythematosus (SLE) through its immune-modulated effects(5). According to the joint study led by the Peking Union Medical College and Chinese Academy of Medical Sciences, resveratrol exhibited protective effects in pristane-induced lupus mice via anti-inflammation and immune-regulatory properties(4).

Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia. The herb has been used in trditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc. its chemical constituent curcumin exhibited anti SLE effects through maintaining the balance between T helper 17 (Th17) and regulatory T cells (Treg)(6).
According to the University of Chicago, curcumin increased the expression of IgG deposits in protection against altered the transport of immune complexes leading to an increase in IgG deposits which could induce inflammatory pathways thereby leading to worsening of the disease(7).
Furthermore, oral administration of turmeric supplementation can decrease proteinuria, hematuria, and systolic blood pressure in patients suffering from relapsing or refractory lupus nephritis, the Shiraz University of Medical Sciences suggested(8).

The smoothie of Green Tea, Blueberry, Peanut and Curcumin may hold a key in further studies in production of effective natural ingredients for prevention and treatment of Systemic lupus erythematosus (SLE) without inducing adverse effects.

People who are at increased risk of any of Systemic lupus erythematosus (SLE)due to family history, weaken immunity... should drink at least one cup daily. People with Systemic lupus erythematosus (SLE), should drink no more than 4 servings daily, depending to the digestive toleration.

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(1) Modifying effect of N-acetyltransferase 2 genotype on the association between systemic lupus erythematosusand consumption of alcohol and caffeine-rich beverages by Kiyohara C1, Washio M, Horiuchi T, Asami T, Ide S, Atsumi T, Kobashi G, Takahashi H, Tada Y; Kyushu Sapporo SLE (KYSS) Study Group.(PubMed)
(2) Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation by Tsai PY1, Ka SM, Chang JM, Chen HC, Shui HA, Li CY, Hua KF, Chang WL, Huang JJ, Yang SS, Chen A.(PubMed)
(3) Epigallocatechin-3-gallate activates Nrf2/HO-1 signaling pathway in cisplatin-induced nephrotoxicity in rats by Sahin K1, Tuzcu M, Gencoglu H, Dogukan A, Timurkan M, Sahin N, Aslan A, Kucuk O.(PubMed)
(4) Resveratrol possesses protective effects in a pristane-induced lupus mouse model by Wang ZL1, Luo XF1, Li MT1, Xu D1, Zhou S1, Chen HZ2, Gao N1, Chen Z1, Zhang LL1, Zeng XF1.(PubMed)
(5) [Effect of resveratrol on the activation of murine CD4(+);T lymphocytes].[Article in Chinese]by Wang Z1, Zeng X, Li M, Luo X.(PubMed)
(6) Treatment of low doses curcumin could modulate Th17/Treg balance specifically on CD4+ T cell cultures ofsystemic lupus erythematosus patients by Handono K1, Pratama MZ2, Endharti AT3, Kalim H2.(PubMed)
(7) Curcumin aggravates CNS pathology in experimental systemic lupus erythematosus by Foxley S1, Zamora M, Hack B, Alexander RR, Roman B, Quigg RJ, Alexander JJ.(PubMed)
(8) Oral supplementation of turmeric decreases proteinuria, hematuria, and systolic blood pressure in patients suffering from relapsing or refractory lupus nephritis: a randomized and placebo-controlled study by Khajehdehi P1, Zanjaninejad B, Aflaki E, Nazarinia M, Azad F, Malekmakan L,Dehghanzadeh GR.(PubMed)
(9) Phytochemicals against lupus by Kyle J. Norton

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