Herbal cayenne processed a significant amount of bioactive compound Capsicum may have a positive and profound effect on normalizing the levels of blood pressure, according to studies.
Hypertension is a medical condition of abnormally high blood pressure, one of the members of the cluster of conditions associated with heart disease and stroke.
Depending on the reading, some researchers suggested if you are in stage one of high blood pressure, your risk of cardiovascular disease is increased by 10% over the next 10 years.
According to the statistics, in the US, approximately 75 million people or 1 of 3 U.S. adults has high blood pressure. High blood pressure can be modified by change of lifestyle.
Most common risk factors of high blood pressure are a poor diet with high in salt and potassium and low vitamin D, physically inactive, excessive alcohol drinking, use of Non-steroidal Anti-inflammatory Drugs (NSAIDs), and aging.
However, not all people with some of the above conditions will develop high blood pressure.
Treatment of stage 1 and 2 hypertension include daily intake of diuretics which lower high blood pressure by reducing sodium and fluid through increased urinary secretion and Bumetanide (Bumex) Chlorthalidone (Hygroton) or Chlorothiazide (Diuril).
Some patients may experience side effects such as a cough, diarrhea or constipation, dizziness or nervousness, tired, weak, and nausea or vomiting.
In a serious case, high blood pressure medication may induce erectile dysfunction. If you are taking high blood pressure medications, please make sure you have discussed the side effects with your doctor.
Some researchers in the concern of the widespread of hypertension in the Western world suggested that the condition may correlate to the promotion of the Western diet over the past few decades.
Dr. Adriana Monge and colleagues examined the Western and Modern Mexican diet pattern and risk of high blood pressure, wrote, "The multivariable-adjusted odds of hypertension in the highest quartile of the Western (W) pattern were 24% higher than the odds for individuals in the lowest quartile"
And, "women in the highest quartile of the MM pattern had 15% higher odds than women in the lowest quartile. The Fruits & Vegetables (FV) pattern was not significantly associated with hypertension".
These results clearly indicated a strong connection of the Western diet pattern in the increased risk of hypertension compared to the lower risk of fruits and vegetable group.
Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belonging to Capsicum annuum, the family Solanaceae, native to sub-tropical and tropical regions.
The pepper has been used in traditional medicine to increases metabolism, enhance circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises, and neuralgia, etc.
The chemical constituents of Cayenne include capsaicin, capsacutin oil, solaine, xanthenes, oleic acid, palmitic acid, etc.
Epidemiological studies linking cayenne in reducing hypertension have not been conclusive, the mechanism of this effect is still a mystery.
Researchers on finding herbal medicine for the treatment of hypertension with no side effects examined the traditionally used medicinal plants against key enzymes relevant for hyperglycemia and hypertension.
Compared to other herbal plants, pepper (Capsicum) inhibited significantly the hypertension relevant angiotensin I-converting enzyme (ACE).
All evaluated pepper (Capsicum) genus exhibited both anti-hyperglycemia and anti-hypertension potential.
The anti-high blood pressure of cayenne probably is associated with the major compound capsaicin, chlorogenic acid, and hydroxycinnamic acid derivatives.
However, in pig study, application capsaicin isolated from the cayenne showed a significantly increased mean arterial blood pressure compared with controls, and a decrease in CGRP synthesis and release contributes to the elevated blood pressure.
Also, there are 2 cases reported of an arterial hypertensive crisis in a patient with large ingestion of peppers and chili peppers the day before and a 19-year-old Italian man with abundant ingestion of peppers and of chili peppers the preceding day.
Additonally, overdoses of cayenne not only induced arterial hypertensive crisis but also acute myocardial infarction with high levels of thyroid stimulating hormone.
The findings strongly suggested cayenne processed an antihypertensive and hypertensive effect in a dose-dependent manner.
This dual mechanisms presented in cayenne may not be explained by conventional medicine. However, traditional Chinese medicine stated cayenne, yang in nature, promotes Qi movement of blood. In a healthy individual, smooth movement of qi reduces the unnecessary blood pressure in blood transportation. On the other hand, if the movement of qi is blocked due to the presence of a high amount of cholesterol that narrows the blood vessel, in inducing higher blood pressure.
The traditional Chinese medicine continued, injection of a high amount of cayenne pepper can cause constriction of blood vessels, leading to narrowing blood flow and risk of hypertension
Taken altogether, there is no doubt that cayenne may be considered a functional remedy for the prevention and treatment of hypertension, but the amount of intake should only be prescribed by related field specialists.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Phenolic compounds, antioxidant activity and in vitro inhibitory potential against key enzymes relevant for hyperglycemia and hypertension of commonly used medicinal plants, herbs and spices in Latin America by Ranilla LG1, Kwon YI, Apostolidis E, Shetty K.(PubMed)
(2) Capsaicin and arterial hypertensive crisis by Patanè S, Marte F, La Rosa FC, La Rocca R.(PubMed)
(3) Capsaicin, arterial hypertensive crisis and acute myocardial infarction associated with high levels of thyroid stimulating hormone by Patanè S, Marte F, Di Bella G, Cerrito M, Coglitore S.(PubMed)
(4) Western and Modern Mexican dietary patterns are directly associated with incident hypertension in Mexican women: a prospective follow-up study by Adriana Monge,1,2 Martín Lajous,1,4 Eduardo Ortiz-Panozo,1 Beatriz L. Rodríguez,2,3José Juan Góngora,2 and Ruy López-Ridaura. (PMC)
Friday, April 12, 2019
Thursday, April 11, 2019
Whole Food Papaya, the Best Anti Diabetes Functional Food, Studies Found
Papaya may be the next generation of whole food for the prevention and treatment of type II diabetes with no side effects, some studies suggested.
Diabetes is a condition characterized by insufficient insulin entering the bloodstream to regulate the glucose.
Most cases of type II diabetes are either caused by cells in pancreas died off or receptor sites clogged up by fat and cholesterol.
In some cases, diabetes is also caused by allergic reactions of cells in the immune system.
Epidemiological studies suggested that obesity, family history, ethnicity, the increase in age, gestation diabetes, polycystic ovary syndrome. and high blood pressure is the most common risk factors associated with the onset of the prediabetes and type II diabetes.
Dr. Stephen S. Rich, in the article "the genetics of diabetes and Its complications", suggested that type II diabetes may be a genetically related disease. Unlike type 1 diabetes, in which there seems to be an autoimmune process, type 2 diabetes is a disease of relative rather than absolute insulin deficiency. Genes involved in type 2 diabetes, with the most promising, replicated findings on chromosomes are 1q21-q24, 2q37, 12q24 and 20.
Untreated and unmanageable type II diabetes may induce complications of the onset of cardiovascular disease, nerve damage (neuropathy). kidney damage (nephropathy), eye damage (retinopathy). foot damage and kin conditions.
Medication used for the treatment of type II diabetes is focused on alleviating the symptoms and improving quality of life and slowing down the progression of the disease.
If you currently intake medicine for treatment of diabetes, please sure you know all the side effects for the preventive measure.
Papaya is a species of Carica Papaya, belonging to the family Caricaceae and native to the tropics of the Americas, and was first cultivated in Mexico and several centuries
Unripe pawpaw fruit (Carica papaya) not only inhibited α-amylase, α-glucosidase but also reduced lipid peroxidation in a dose-dependent manner, in rat pancreas(1).
The key enzymes of α-amylase, α-glucosidase, involved in the digestion of carbohydrates, have been linked to the onset of type 2 diabetes. Inhibition of these enzymes can significantly reduce the post-prandial increase of blood glucose and have been also used for management of blood glucose level in type 2 diabetic and borderline patients by therapists (2).
In streptozotocin-induced diabetic rats study, the aqueous extract of leaves of C. papaya administered strongly controlled blood glucose levels(3), through the prevention of hepatocyte disruption, as well as accumulation of glycogen and lipids via its hypoglycemic and antioxidant effect(4)
In a new study, conducted by the researchers at the Davis Heart and Lung Research Institute, fermented papaya preparation was tested whether it improves dermal wound healing outcomes in adult diabetic mice by preventing the risk of infections(5).
The result was astonishing, the fermentation not only up-regulated the Sp1 DNA binding activity(modulating the cellular response to DNA damage) in Peripheral blood mononuclear cells (PBMC) but also the protein and mRNA expression of Rac2(regulates a number of cellular functions)(5).
A randomized controlled clinical trial conducted at the Cardiac Centre, ANDI Centre of Excellence for Biomedical and Biomaterials Research and Department of Biosciences University of Mauritius, suggested that oral administration of 6g FPP®/day for a period of 14 weeks could improve the general health status of several organs targeted by oxidative stress during diabetes and the supplement may be used in the management the complications of diabetes such as cardiovascular disease, neurological disease and other conditions worsened by overt inflammation and oxidative stress(6).
Taken altogether, unripe, fermented papaya and its' leaves may be effective in diabetic management by controlling the levels of glucose and reduced risk of complications.
Some Western researchers insisted that large sample size and multicenter studies are necessary to validate its effectiveness by identifying the ingredients which are comparable to recently pharmaceutical medicine in use because geography, environment, time of harvest, etc. may influence the concentration of the food cultivation.
In fact, herbalists have long acknowledged that the external factors (mentioned above) may alter the quality of the herbs and foods by classifying these difference either through price or formula differentiation.
Indeed, the effectiveness with little or no adverse side effects of the formula is not the concentration of individual herb and a herb itself but the interaction of all ingredients in a herb and herbs in the same formula. Extracting only one ingredient of the herb for treatment of certain diseases may be effective but enhances complicated consequences.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.References
(1) Inhibition of key enzymes linked to type 2 diabetes and sodium nitroprusside-induced lipid peroxidation in rat pancreas by water-extractable phytochemicals from unripe pawpaw fruit (Carica papaya) by Oboh G, Olabiyi AA, Akinyemi AJ, Ademiluyi AO.(PubMed)
(2) Natural products as alpha-amylase and alpha-glucosidase inhibitors and their hypoglycaemic potential in the treatment of diabetes: an update by Tundis R1, Loizzo MR, Menichini F.(PubMed)
(3) Antihyperglycemic and hypolipidemic activities of aqueous extract of Carica papaya Linn. leaves in alloxan-induced diabetic rats by Maniyar Y, Bhixavatimath P.(PubMed)
(4) Hypoglycemic effect of Carica papaya leaves in streptozotocin-induced diabetic rats by Juárez-Rojop IE1, Díaz-Zagoya JC, Ble-Castillo JL, Miranda-Osorio PH, Castell-Rodríguez AE, Tovilla-Zárate CA, Rodríguez-Hernández A, Aguilar-Mariscal H, Ramón-Frías T, Bermúdez-Ocaña DY.(PubMed)
(5) Correction of aberrant NADPH oxidase activity in blood-derived mononuclear cells from type II diabetes mellitus patients by a naturally fermented papaya preparation by Dickerson R1, Deshpande B, Gnyawali U, Lynch D, Gordillo GM, Schuster D, Osei K, Roy S.(PubMed)
(6) Effects of a short term supplementation of a fermented papayapreparation on biomarkers of diabetes mellitus in a randomized Mauritian population by Somanah J1, Aruoma OI, Gunness TK, Kowelssur S, Dambala V, Murad F, Googoolye K, Daus D, Indelicato J, Bourdon E, Bahorun T.(PubMed)
(6) Genetics of Diabetes and Its Complications by Stephen S. Rich
Wednesday, April 10, 2019
Phytochemical Allicin, the Anti Colon Cancer Bioactive compound
Phytochemicals may be the next potential sources of a new medicine for the treatment of diseases with little or no side effects.
Phytochemical allicin may be the next natural ingredient for the prevention and treatment of colon cancer with no side effects, some scientists suggested.
Colon is a large intestine formed part of the digestive system where water is reabsorbed and waste material is stored as feces before being removed.
Colon cancer is the medical condition characterized by the cell growth irregularly and disorderly due to change of DNA.
Most cases of colon cancer start in the cell on the surface of the inner lining of the colon. However, at the later stage, colon cancer may cause secondary metastasis, leading to cancers forming on other tissues and organs, a distance away through lymph and blood.
According to the statistics, the risk of colon cancer has been rising in younger age groups coincidently with the declining rate in older age groups.
Sadly, the proportion of cases diagnosed in individuals younger than age 50 increased from 6% in 1990 to 11% in 2013. Most of these cases (72%) occur in people who are in their 40s.
The causes of colon cancer are unknown, Some researchers suggested that the widespread colon cancer over the past few decades in the developed world probably is the result of the promotion of the Western diet that leads to obesity.
Dr. E E Frezza, the lead scientist at the Texas Tech University Health Sciences Cente, in the study to examine obesity in the risk colon cancer wrote, "Obesity is a risk factor for many diseases" and "Visceral abdominal fat has been identified as the essential fat depot for pathogenetic theories that relate obesity and colon cancer".
And, "Although WC is better established as a measure of obesity than BMI, the evidence for colon cancer risk is not secure on this point; combining BMI and WC measurements would appear, at present, to be the wisest approach for colon cancer risk assessment".
The finding strongly suggested that obesity is a major risk factor of colon cancer.
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
With an aim to find a natural ingredient for the treatment of colon cancer with no side effects, researchers at The Hebrew University of Jerusalem examined the effects of allicin on cell proliferation of colon cancer cell lines HCT-116, LS174T, HT-29, and Caco-2.
Injection of allicin preparation exerted a time- and dose-dependent cytotoxic effect on these cells at concentrations ranging from 6.2 to 310 μM.
Treatment with allicin induced HCT-116 apoptotic cell death through reducing the numbers of the chromosome in the DNA in the cancer cells, increasing the function and proteins associated with cell apoptosis and decreasing the expression of proteins involved cell proliferation and migration.
Futhermore, allicin treatment also induced cell death through cancer cell degradation.
Moreover, allicin application also activated the protein which protects the normal cell against oxidative damage triggered by injury and inflammation and reduces the function of the phytochemicals in the inhibition of the HCT-116 proliferation without affecting the cancer apoptosis.
In vivo and vitro, researchers evaluated the combined effect of allicin and CPT-11 against the human colon cancer cell line LoVo.
Allicin treatment alone inhibited the growth of LoVo cells in a dose and time-dependent manner, with an IC50 value of 32.23, 10.74, 6.58 mg x L(-1) at 24 h, 48 h, and 72 h, respectively.
The apoptosis rate of LoVo cells increased progressively as the cells were treated with increasing concentration of allicin in 24 h, while the apoptosis rate achieved peak value when the cells were treated with allicin at the concentration of 8 mg x L(-1) in 48 h.
These results strongly suggested that low concentrations of allicin (< 4 mg x L(-1)) leads to G2/M cell cycle arrest, and higer concentrations ( > 4 mg x L(-1)) exerts G1 + G2/M cell cycle arrest in 24 h.
Compared with a single use of CPT-11, the combined use of CPT-11 and allicin (4.0, 8.0 mg x L(-1), respectively) showed increasing cytotoxicity on the LoVo cells, with IC50 of 24 h decreasing from 47.5 to 7.4 and 7.2 mg x L(-1), respectively.
Dr. Gao Y, the lead scientist, wrote in the final report, "Allicin has significant anti-proliferation effect on human colon cancer cell line LoVo by induction of apoptosis and arrestment of the cell cycle and can enhance the cytotoxicity of CPT-11 on the colon cancer LoVo cell".
Taken altogether, phytochemical Allicin may be considered a bioactive compound for the prevention and combined with the primary medicine for the treatment of colon cancer, pending to large sample and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How ToPermanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Allicin purified from fresh garlic cloves induces apoptosis in colon cancer cells via Nrf2 by Bat-Chen W, Golan T, Peri I, Ludmer Z, Schwartz B.(PubMed)
(2) [Allicin enhances cytotoxicity of CPT-11 to colon cancer LoVo cell in vitro]. [Article in Chinese] by Gao Y, Liu Y, Cao W, Deng Z, Liu H, Xu L, Chen X.(PubMed)
(3) Influence of obesity on the risk of developing colon cancer by E E Frezza, M S Wachtel, and M Chiriva‐Internati. (PMC)
Herbal Ginger, the Natural Antibiofilm Remedy with No Side Effects
Scientists may have a kitchen remedy which processes a potential to improve the immune function against infection, some studies suggested.
A biofilm is a system that can be adapted internally to environmental conditions by its inhabitants. In other words, biofilm-forming from bacteria is one of the common forms of bacterial infection affecting up to 80% of human bacterial infections.
In biology, biofilm used by the bacteria as a natural defense mechanism of bacteria to survive under harsh environments, by attaching to a solid surface in a large community, including the skin, teeth, and mucosa.
Bacterial initiates biofilm formation with an aim to greatly enhance survival in hosts and cause chronic infections, leading to long-term inflammation and tissue damages.
The formation of a biofilm of bacteria may go through 2 stages, the adhesion phase is the stage that the bacteria attach to the surface or accumulates on a surface, After the adhesion phase, the bacteria enter the colonial phase, where the bacteria continue to grow, leading to the formation of dense bacterial aggregates.
Dr. Li XH, the lead scientist in examing the new anti-biofilm agents, said, "In biofilms, microorganisms become much more resistant to antimicrobial treatments, harsh environmental conditions, and host immunity".
And, "Currently, it is believed over 80% of chronic infectious diseases are mediated by biofilms, and it is known that conventional antibiotic medications are inadequate at eradicating this biofilm-mediated infection".
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Scientists on finding a natural compound with anti-biofilm activity for the treatment of microbial infection evaluated the ginger anti-biofilm formation effects.
Injection of ginger exerted a strong inhibition against Pseudomonas aeruginosa PA14 biofilm formation.
The anti-biofilm activity of ginger caused a reduction of 39–56% when the ginger extract was added to the culture.
The ginger extract also decreased the production of extracellular polymeric substances, the fundamental component that determines the physiochemical properties of a biofilm, according to the chemical analysis and confocal laser scanning microscopy.
Furthermore, ginger extract formed noticeably less rugose colonies on agar plates containing Congo red and facilitated swarming motility on soft agar plates.
The ginger extract also inhibited biofilm formation in both Gram-positive and Gram-negative bacteria.
The efficacy of ginger extract was attributed to the reduced level of a second messenger, bis-(3′-5′)-cyclic dimeric guanosine monophosphate in the induction of biofilm formation.
Also, surface biofilm cells formed with ginger extract detached more easily with surfactant than did those without ginger extract.
The results strongly support the use of ginger as a broad spectrum biofilm inhibitor, in the reduction of bacterial biofilm formation, a major cause of serious health problems.
In order to reveal more information about the ginger effect against biofilm formation, researchers examined the bioactive compounds on Candida albicans.
6-gingerol, 8-gingerol, and 6-shogaol effectively inhibited biofilm formation and 6-shogaol at 10 μg/ml significantly reduced C. albicans biofilm formation with no harming the planktonic cell growth.
Moreover, 6-gingerol and 6-shogaol inhibited hyphal growth in embedded colonies and free-living planktonic cells and prevented cell aggregation.
Additionally, 6-gingerol and 6-shogaol reduced C. albicans virulence in a nematode infection model without causing toxicity at the tested concentrations.
Dr. Jin-Hyung Lee,, the lead scientist wrote in the final report, "These results highlight the antibiofilm and antivirulence activities of the ginger components, 6-gingerol and 6-shogaol, against a drug-resistant C. albicans strain".
Taken altogether, ginger processed a high amount of bioactive compound may be considered a functional remedy for the prevention of bacterial infection by inhibiting the biofilm activity of micro pathogens.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Ginger Extract Inhibits Biofilm Formation by Pseudomonas aeruginosa PA14 by Han-Shin Kim and Hee-Deung Park. (PMC)
(2) Antibiofilm and Antivirulence Activities of 6-Gingerol and 6-Shogaol Against Candida albicans Due to Hyphal Inhibition by Jin-Hyung Lee,1,† Yong-Guy Kim,1,† Pilju Choi,2 Jungyeob Ham,2 Jae Gyu Park,3,* andJintae Lee. (PMC)
(3) Antibiofilm agents: A new perspective for antimicrobial strategy by Li XH1, Lee JH2. (PubMed)
A biofilm is a system that can be adapted internally to environmental conditions by its inhabitants. In other words, biofilm-forming from bacteria is one of the common forms of bacterial infection affecting up to 80% of human bacterial infections.
In biology, biofilm used by the bacteria as a natural defense mechanism of bacteria to survive under harsh environments, by attaching to a solid surface in a large community, including the skin, teeth, and mucosa.
Bacterial initiates biofilm formation with an aim to greatly enhance survival in hosts and cause chronic infections, leading to long-term inflammation and tissue damages.
The formation of a biofilm of bacteria may go through 2 stages, the adhesion phase is the stage that the bacteria attach to the surface or accumulates on a surface, After the adhesion phase, the bacteria enter the colonial phase, where the bacteria continue to grow, leading to the formation of dense bacterial aggregates.
Dr. Li XH, the lead scientist in examing the new anti-biofilm agents, said, "In biofilms, microorganisms become much more resistant to antimicrobial treatments, harsh environmental conditions, and host immunity".
And, "Currently, it is believed over 80% of chronic infectious diseases are mediated by biofilms, and it is known that conventional antibiotic medications are inadequate at eradicating this biofilm-mediated infection".
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Scientists on finding a natural compound with anti-biofilm activity for the treatment of microbial infection evaluated the ginger anti-biofilm formation effects.
Injection of ginger exerted a strong inhibition against Pseudomonas aeruginosa PA14 biofilm formation.
The anti-biofilm activity of ginger caused a reduction of 39–56% when the ginger extract was added to the culture.
The ginger extract also decreased the production of extracellular polymeric substances, the fundamental component that determines the physiochemical properties of a biofilm, according to the chemical analysis and confocal laser scanning microscopy.
Furthermore, ginger extract formed noticeably less rugose colonies on agar plates containing Congo red and facilitated swarming motility on soft agar plates.
The ginger extract also inhibited biofilm formation in both Gram-positive and Gram-negative bacteria.
The efficacy of ginger extract was attributed to the reduced level of a second messenger, bis-(3′-5′)-cyclic dimeric guanosine monophosphate in the induction of biofilm formation.
Also, surface biofilm cells formed with ginger extract detached more easily with surfactant than did those without ginger extract.
The results strongly support the use of ginger as a broad spectrum biofilm inhibitor, in the reduction of bacterial biofilm formation, a major cause of serious health problems.
In order to reveal more information about the ginger effect against biofilm formation, researchers examined the bioactive compounds on Candida albicans.
6-gingerol, 8-gingerol, and 6-shogaol effectively inhibited biofilm formation and 6-shogaol at 10 μg/ml significantly reduced C. albicans biofilm formation with no harming the planktonic cell growth.
Moreover, 6-gingerol and 6-shogaol inhibited hyphal growth in embedded colonies and free-living planktonic cells and prevented cell aggregation.
Additionally, 6-gingerol and 6-shogaol reduced C. albicans virulence in a nematode infection model without causing toxicity at the tested concentrations.
Dr. Jin-Hyung Lee,, the lead scientist wrote in the final report, "These results highlight the antibiofilm and antivirulence activities of the ginger components, 6-gingerol and 6-shogaol, against a drug-resistant C. albicans strain".
Taken altogether, ginger processed a high amount of bioactive compound may be considered a functional remedy for the prevention of bacterial infection by inhibiting the biofilm activity of micro pathogens.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Ginger Extract Inhibits Biofilm Formation by Pseudomonas aeruginosa PA14 by Han-Shin Kim and Hee-Deung Park. (PMC)
(2) Antibiofilm and Antivirulence Activities of 6-Gingerol and 6-Shogaol Against Candida albicans Due to Hyphal Inhibition by Jin-Hyung Lee,1,† Yong-Guy Kim,1,† Pilju Choi,2 Jungyeob Ham,2 Jae Gyu Park,3,* andJintae Lee. (PMC)
(3) Antibiofilm agents: A new perspective for antimicrobial strategy by Li XH1, Lee JH2. (PubMed)
Tuesday, April 9, 2019
Herbal Aloe Vera Improves the Function of Immune System with No Side Effects
Scientists may have found a natural ingredient for the enhancement of the immune system with no side effects, according to studies.
The immune system is the set of cells associated with the activity against antigens or infectious agents.
It is one of the body's defense system against diseases.
The immune system does a great job of keeping people healthy and preventing infections.
Immune dysfunction is a chronic condition, depending on the parts of the immune system affected.
There are 2 types of immune dysfunction. The underactive immune system is also known as weakened immune system People with the underactive immune system are susceptible to infection, recurrent infections, autoimmune disorders, damage to heart, lungs, nervous system or digestive tract, increased risk of cancer, malnutrition, and death from serious infection.
On the other hand, the active immune system is also known as autoimmune diseases. In this case, patients suffer diseases associated with the immune system attacks the body tissue.
Immunomodulation is a process in which an immune response is altered to the desired level. In other words, under the immunomodulatory effect, the immune system is responding correctly to the desire of the body, regardless of types of immune dysfunction.
Dr. Jeffrey A. Bluestone, the lead scientist in the study "Current and Future Immunomodulation Strategies to Restore Tolerance in Autoimmune Diseases" wrote, "Considerable progress has been made in the immunomodulation of autoimmune diseases and the understanding of the complex molecular and cellular pathways targeted by novel treatments".
And "... a number of immunotherapies have become the standard of care and greatly improved the clinical outcome and quality of life of patients with some autoimmune diseases".
These results strongly suggested that immunomodulation can be used for the prevention and treatment of under and overactive immune function.
Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan.
The herbal plant has become very popular for commercial cultivation due to its health benefits. Aloe vera has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated cholesterol, etc. It is also one of many popular herbs studied in scientific ways with some conflicting results.
The ten main areas of chemical constituents of Aloe vera include amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.
They all work together in a synergistic way to create healing and health-giving benefits, according to Gertrude Baldwin in the article of THE BENEFITS OF THE USE OF ALOE VERA IN HERBAL PREPARATIONS.
With an aim to find the pharmacological potential of Aloe arborescens Miller leaf components against the immune dysfunction, researchers examined the to immune modulatory effects on the Sparus aurata fibroblast cell line SAF-1.
According to the application of Aloe extract at different concentrations (1.2-4.8 mg ml(-1)) for various times (24-72 h) for the treatment of the cells, the lowest concentration did not provoke any cellular damage observable by SEM and did not affect ATP amounts after 24 and 48 h, while even induced a significant increase over controls after 72 h.
However, the Aloe extract at a concentration of 1.2 mg ml(-1)) exerted a powerful immune stimulation in exhibiting an effect on interconnected genes in the SAF-1 cells involved in different aspects of the immune responses.
Researchers at the end of the experiment wrote, "A. arborescens to prevent or oppose bacterial and viral fish diseases and to face, as an alternative strategy based on natural plant extracts, the growing unwillingness to rely upon standard solutions involving antibiotics or antimicrobial chemicals".
Further, the investigation of the effect of an aloe polymannose multi-nutrient complex (APMC) formula on cognitive and immune functioning over 12 months among adults diagnosed with AD.
The participants were given to 4 teaspoons of the formula per day. The results were assessed at baseline and 12 months.
The formula demonstrated a significantly improved at 9 and 12 months compared to baseline, and 46% of our sample showed clinically-significant improvement (≥4-point change) from baseline to 12 months, according to the mean ADAS-cog cognition score.
Participants showed a significant decrease in protein associated with immune response in the activation of proinflammatory cytokines with few, temporary adverse reactions.
In other words, the formula displayed strong immune modulatory effects in regulating the immune responses on patients with AD.
Taken altogether, herbal Aloe vera may be considered a functional remedy in regulation and adjustment of the immune system against stimuli, including allergens, infectious pathogens with no side effect.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(3) The inner gel component of Aloe vera suppresses bacterial-induced pro-inflammatory cytokines from human immune cells. by Habeeb F, Stables G, Bradbury F, Nong S, Cameron P, Plevin R, Ferro VA.(PubMed)
(4) Immune modulatory effects of Aloe arborescens extract on the piscine SAF-1 cell line. by Picchietti S, Bernini C, Belardinelli MC, Ovidi E, Taddei AR, Guerra L, Abelli L, Fausto AM.(PubMed)
(5) The effect of an aloe polymannose multinutrient complex on cognitive and immune functioning in Alzheimer's disease. by Lewis JE, McDaniel HR, Agronin ME, Loewenstein DA, Riveros J, Mestre R, Martinez M, Colina N, Abreu D, Konefal J, Woolger JM, Ali KH.(PubMed)
(4) Current and Future Immunomodulation Strategies to Restore Tolerance in Autoimmune Diseases by Jeffrey A. Bluestone and Hélène Bour-Jordan. (PMC)
Turmeric, the Natural Remedy for the Treatment of Metabolic Syndrome (MS)
Scientists may have found a natural herbal remedy for the treatment of metabolic syndrome with no side effects, according to studies.
Metabolic syndrome is a cluster of conditions associated with an increased risk of cardiovascular disease and diabetes including too much fat around the waist, high blood sugar and cholesterol and pressure, high triglycerides and low high-density lipoprotein (HDL) cholesterol.
If you have any 3 of the aforementioned conditions, you are at a higher risk of having CVD and diabetes.
The exact causes of metabolic syndrome are unidentified. However, researchers suggested eating too many calories, particularly in high-fat diet, physical inactivity, and excessive weight gain are some of the most common and prevalent factors in elevated the risk of metabolic syndrome in the Western world.
Most people with metabolic syndrome do not experience any symptoms until the condition progression into a later stage, overtimes, leading to insulin resistance and plagues built-up on the wall of the arteries.
Other risk factors increased the risk of metabolic syndrome include aging, race, family history, long-term hormone imbalance such as polycystic ovary syndrome (PCOS), gestational diabetes.
Some researchers in the concern about the widespread metabolic syndrome in obese patients suggested that the promotion of the Western diet over the past many decades may be one of the culprits in inducing the onset of metabolic syndrome.
Dr. the lead scientist in the cardiovascular disease team said, "The cellular mechanisms of metabolic syndrome include mitochondrial overload, de novo lipogenesis, hepatic insulin resistance, and hyperinsulinemia, reactive oxygen species formation, endoplasmic reticulum stress, and the unfolded protein response"
And, "Specific alterations of the Western Diet uniquely drive this process and are unrelated to calories. These alterations include too little fiber, omega-3 fatty acids, and micronutrients, and too many omega-6 fatty acids, trans-fats, branched-chain amino acids, ethanol, and fructose. The food industry invokes personal responsibility while denying any corporate responsibility and citing scientific, policy, and social arguments. However, their responses obfuscate the scientific truth in order to obviate their culpability".
The findings suggested that obesity is a marker of the metabolic syndrome rather than a cause, However, if you are obese, your risk of metabolic syndrome increases substantially.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to find a natural remedy for the treatment of metabolic syndrome, researchers compared the clinical efficacy of black seeds and turmeric alone and its co-administration in lower doses among patients with metabolic syndrome (MS).
The double-blind-randomized-controlled trial included healthy males (n=250), who screened positive for MS, were randomized to either black seeds (1.5g/day), turmeric (2.4g/day), its combination (900mg black seeds and 1.5g turmeric/day) or placebo for 8 weeks.
At 4 weeks, compared to baseline, turmeric alone significantly improved a number of certain conditions of metabolic syndrome such as body-mass-index (BMI), body-fat-percent (BF%), waist circumference (WC).
Combined with black seeds, turmeric improved all parameters except HDL-cholesterol with lower fasting blood glucose (FBG) and LDL-cholesterol, compared to placebo.
At the 8 weeks, turmeric reduced LDL-cholesterol and c-reactive protein (CRP), a marker of inflammation, and the combination group with 60% dose of the individual herbs showed an improvement in all parameters compared to baseline.
Based on the findings, researchers said, "The combination of Black seeds and Turmeric can, therefore, be recommended with lifestyle modification as a starting point for patients with MetS to halt its future complications and progression".
In order to confirm the efficacy of black seeds used combined with turmeric for the treatment of metabolic syndrome, researchers once against conducted a joint study using a fructose-fed rat model of MS.
in vivo, different doses of black seeds and turmeric, individually and in combination, were administered to fructose-fed rats for up to 6 weeks with characteristic features of MS.
At 3 weeks of the treatment, turmeric lowered low-density lipoprotein cholesterol, compared to coadministration which reduced both high blood pressure and hypertriglyceridemia.
At 6 weeks, the coadministration of both herbs, at half the doses of individual herbs, was the most effective in preventing hypertension, hyperglycemia, dyslipidemia, hyperinsulinemia, and endothelial dysfunction compared to those of individual herbs.
The results strongly suggested that turmeric used alone or combined with black seeds may be considered a functional food or formula for the prevention and treatment of metabolic syndrome by inhibiting the conditions in the cluster of the MS, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Clinical efficacy of the co-administration of Turmeric and Black seeds (Kalongi) in metabolic syndrome - a double blind randomized controlled trial - TAK-MetS trial by Amin F1, Islam N2, Anila N3, Gilani AH. (PubMed)
(2) Coadministration of black seeds and turmeric shows enhanced efficacy in preventing metabolic syndrome in fructose-fed rats by Amin F1, Gilani AH, Mehmood MH, Siddiqui BS, Khatoon N. (PubMed)
(3) Metabolic Syndrome and Obesity in Childhood and AdolescenceEditor(s): Kiess, W. (Leipzig), Wabitsch, M. (Ulm), Maffeis, C. (Verona) and Sharma, A.M. (Edmonton, Alta.). (Karger)
Metabolic syndrome is a cluster of conditions associated with an increased risk of cardiovascular disease and diabetes including too much fat around the waist, high blood sugar and cholesterol and pressure, high triglycerides and low high-density lipoprotein (HDL) cholesterol.
If you have any 3 of the aforementioned conditions, you are at a higher risk of having CVD and diabetes.
The exact causes of metabolic syndrome are unidentified. However, researchers suggested eating too many calories, particularly in high-fat diet, physical inactivity, and excessive weight gain are some of the most common and prevalent factors in elevated the risk of metabolic syndrome in the Western world.
Most people with metabolic syndrome do not experience any symptoms until the condition progression into a later stage, overtimes, leading to insulin resistance and plagues built-up on the wall of the arteries.
Other risk factors increased the risk of metabolic syndrome include aging, race, family history, long-term hormone imbalance such as polycystic ovary syndrome (PCOS), gestational diabetes.
Some researchers in the concern about the widespread metabolic syndrome in obese patients suggested that the promotion of the Western diet over the past many decades may be one of the culprits in inducing the onset of metabolic syndrome.
Dr. the lead scientist in the cardiovascular disease team said, "The cellular mechanisms of metabolic syndrome include mitochondrial overload, de novo lipogenesis, hepatic insulin resistance, and hyperinsulinemia, reactive oxygen species formation, endoplasmic reticulum stress, and the unfolded protein response"
And, "Specific alterations of the Western Diet uniquely drive this process and are unrelated to calories. These alterations include too little fiber, omega-3 fatty acids, and micronutrients, and too many omega-6 fatty acids, trans-fats, branched-chain amino acids, ethanol, and fructose. The food industry invokes personal responsibility while denying any corporate responsibility and citing scientific, policy, and social arguments. However, their responses obfuscate the scientific truth in order to obviate their culpability".
The findings suggested that obesity is a marker of the metabolic syndrome rather than a cause, However, if you are obese, your risk of metabolic syndrome increases substantially.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to find a natural remedy for the treatment of metabolic syndrome, researchers compared the clinical efficacy of black seeds and turmeric alone and its co-administration in lower doses among patients with metabolic syndrome (MS).
The double-blind-randomized-controlled trial included healthy males (n=250), who screened positive for MS, were randomized to either black seeds (1.5g/day), turmeric (2.4g/day), its combination (900mg black seeds and 1.5g turmeric/day) or placebo for 8 weeks.
At 4 weeks, compared to baseline, turmeric alone significantly improved a number of certain conditions of metabolic syndrome such as body-mass-index (BMI), body-fat-percent (BF%), waist circumference (WC).
Combined with black seeds, turmeric improved all parameters except HDL-cholesterol with lower fasting blood glucose (FBG) and LDL-cholesterol, compared to placebo.
At the 8 weeks, turmeric reduced LDL-cholesterol and c-reactive protein (CRP), a marker of inflammation, and the combination group with 60% dose of the individual herbs showed an improvement in all parameters compared to baseline.
Based on the findings, researchers said, "The combination of Black seeds and Turmeric can, therefore, be recommended with lifestyle modification as a starting point for patients with MetS to halt its future complications and progression".
In order to confirm the efficacy of black seeds used combined with turmeric for the treatment of metabolic syndrome, researchers once against conducted a joint study using a fructose-fed rat model of MS.
in vivo, different doses of black seeds and turmeric, individually and in combination, were administered to fructose-fed rats for up to 6 weeks with characteristic features of MS.
At 3 weeks of the treatment, turmeric lowered low-density lipoprotein cholesterol, compared to coadministration which reduced both high blood pressure and hypertriglyceridemia.
At 6 weeks, the coadministration of both herbs, at half the doses of individual herbs, was the most effective in preventing hypertension, hyperglycemia, dyslipidemia, hyperinsulinemia, and endothelial dysfunction compared to those of individual herbs.
The results strongly suggested that turmeric used alone or combined with black seeds may be considered a functional food or formula for the prevention and treatment of metabolic syndrome by inhibiting the conditions in the cluster of the MS, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Clinical efficacy of the co-administration of Turmeric and Black seeds (Kalongi) in metabolic syndrome - a double blind randomized controlled trial - TAK-MetS trial by Amin F1, Islam N2, Anila N3, Gilani AH. (PubMed)
(2) Coadministration of black seeds and turmeric shows enhanced efficacy in preventing metabolic syndrome in fructose-fed rats by Amin F1, Gilani AH, Mehmood MH, Siddiqui BS, Khatoon N. (PubMed)
(3) Metabolic Syndrome and Obesity in Childhood and AdolescenceEditor(s): Kiess, W. (Leipzig), Wabitsch, M. (Ulm), Maffeis, C. (Verona) and Sharma, A.M. (Edmonton, Alta.). (Karger)
Monday, April 8, 2019
Herbal Aloe Vera, the Potential Anti Prostate Cancer Functional Remedy
Herbal Aloe vera may be used for the prevention and treatment of prostate cancer with no side effects, some scientists suggested.
Prostate cancer is slow-growing cancer characterized by irregular cell growth in the prostate tissue.
Most cases of prostate cancer start in the cells on the surface of the inner lining tissue. However, at
the advanced stage, cancerous prostate cells can travel a distance away to infect other healthy tissue and organs, causing the secondary metastasis. Most often, prostate cancer spreads to the bones or lymph nodes.
Most prostate cancers may be detected during the physical (rectum) exams.
According to the statistic, 1 man in 9 will be diagnosed with prostate cancer during his lifetime. 6 cases in 10 are diagnosed in men aged 65 or older and the average age at the time of diagnosis is about 66.
The 5-year survival rate for most men with stage 0 and 1 prostate cancer is nearly 100%. Ninety-eight percent (98%) are alive after 10 years.
These results strongly indicated that men who are at a higher risk of prostate cancer due to family history and genetic proposition should have a prostate exam taken every year.
Besides aging, other most common risk factors of prostate cancer include family history, ethnicity, genetic preposition, exposure to agent orange and eating habits.
Dr. Wambui G. Gathirua-Mwangi, the lead author in the cancer team in the joint study led by the Indiana University, wrote, "Epidemiologic studies have overall showed that the habitual consumption of a diet high in saturated fat, well-done meats, and calcium is associated with an increased risk of advanced prostate cancer".
And, "measure the nutrients and their biochemical indicators, the risk of advanced prostate cancer, which is fatal and thus clinically significant, may be reduced by dietary modification or chemoprevention".
The finding strongly indicated a healthy diet high in fruits and vegetables and whole grain and low in
saturated and trans fat, red meat and processed foods have a decreased risk of prostate cancer.
Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits.
The herbal plant has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated cholesterol, etc. It is also one of many popular herbs studied in scientific ways with some conflicting results.
The ten main areas of chemical constituents of Aloe vera include Aloe-Emodin, amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.
On finding a natural compound or ingredient for the treatment of prostate cancer with no side effects, researchers at the Korea Research Institute of Bioscience and Biotechnology evaluated phytochemical Aloe-emodin, a bioactive compound isolated from the Aloe vera against prostate cancer on the protein
Aloe-emodin inhibited both proliferation and anchorage-independent growth of PC3 cells.
The efficacy of the inhibited was found to involve proteins that exhibit androgen-refractory prostate cell proliferation and anchorage-independent growth through cancer cell metabolism.
Furthermore, Aloe-emodin demonstrated a significant effect against the activation of a protein (mTORC2) in stimulating the cancer cell proliferation and migration.
Interestingly, researchers also found that Aloe-emodin also inhibits the gene associated with tumor promoter, namely Protein kinase C alpha (PKCα).
Expression of protein kinase C alpha (PKCα) has a strong implication in cancer metastasis and poor prognosis.
In other words, Aloe-emodin displays significant anti-prostate cancer properties by inhibiting cancer cell proliferation, migration through binging to proteins associated with them.
In vivo, Aloe-emodin also exhibited tumor suppression effects in an athymic nude mouse model.
Dr. Liu K after taking into account co and confounders said, "aloe-emodin suppresses prostate cancer progression by targeting mTORC2".
Taken altogether, herbal Aloe vera may be considered a functional remedy for the prevention and combined with primary medicine for the treatment of prostate cancer with no side effect, pending to the confirmation of large sample size and multicenter human study.
Intake of supplement Aloe-emodin should be taken with extreme care to prevent overdoses induced acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2 by Liu K, Park C, Li S, Lee KW, Liu H, He L, Soung NK, Ahn JS, Bode AM, Dong Z, Kim BY, Dong Z.(PubMed)
Prostate cancer is slow-growing cancer characterized by irregular cell growth in the prostate tissue.
Most cases of prostate cancer start in the cells on the surface of the inner lining tissue. However, at
the advanced stage, cancerous prostate cells can travel a distance away to infect other healthy tissue and organs, causing the secondary metastasis. Most often, prostate cancer spreads to the bones or lymph nodes.
Most prostate cancers may be detected during the physical (rectum) exams.
According to the statistic, 1 man in 9 will be diagnosed with prostate cancer during his lifetime. 6 cases in 10 are diagnosed in men aged 65 or older and the average age at the time of diagnosis is about 66.
The 5-year survival rate for most men with stage 0 and 1 prostate cancer is nearly 100%. Ninety-eight percent (98%) are alive after 10 years.
These results strongly indicated that men who are at a higher risk of prostate cancer due to family history and genetic proposition should have a prostate exam taken every year.
Besides aging, other most common risk factors of prostate cancer include family history, ethnicity, genetic preposition, exposure to agent orange and eating habits.
Dr. Wambui G. Gathirua-Mwangi, the lead author in the cancer team in the joint study led by the Indiana University, wrote, "Epidemiologic studies have overall showed that the habitual consumption of a diet high in saturated fat, well-done meats, and calcium is associated with an increased risk of advanced prostate cancer".
And, "measure the nutrients and their biochemical indicators, the risk of advanced prostate cancer, which is fatal and thus clinically significant, may be reduced by dietary modification or chemoprevention".
The finding strongly indicated a healthy diet high in fruits and vegetables and whole grain and low in
saturated and trans fat, red meat and processed foods have a decreased risk of prostate cancer.
Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits.
The herbal plant has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated cholesterol, etc. It is also one of many popular herbs studied in scientific ways with some conflicting results.
The ten main areas of chemical constituents of Aloe vera include Aloe-Emodin, amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.
On finding a natural compound or ingredient for the treatment of prostate cancer with no side effects, researchers at the Korea Research Institute of Bioscience and Biotechnology evaluated phytochemical Aloe-emodin, a bioactive compound isolated from the Aloe vera against prostate cancer on the protein
Aloe-emodin inhibited both proliferation and anchorage-independent growth of PC3 cells.
The efficacy of the inhibited was found to involve proteins that exhibit androgen-refractory prostate cell proliferation and anchorage-independent growth through cancer cell metabolism.
Furthermore, Aloe-emodin demonstrated a significant effect against the activation of a protein (mTORC2) in stimulating the cancer cell proliferation and migration.
Interestingly, researchers also found that Aloe-emodin also inhibits the gene associated with tumor promoter, namely Protein kinase C alpha (PKCα).
Expression of protein kinase C alpha (PKCα) has a strong implication in cancer metastasis and poor prognosis.
In other words, Aloe-emodin displays significant anti-prostate cancer properties by inhibiting cancer cell proliferation, migration through binging to proteins associated with them.
In vivo, Aloe-emodin also exhibited tumor suppression effects in an athymic nude mouse model.
Dr. Liu K after taking into account co and confounders said, "aloe-emodin suppresses prostate cancer progression by targeting mTORC2".
Taken altogether, herbal Aloe vera may be considered a functional remedy for the prevention and combined with primary medicine for the treatment of prostate cancer with no side effect, pending to the confirmation of large sample size and multicenter human study.
Intake of supplement Aloe-emodin should be taken with extreme care to prevent overdoses induced acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2 by Liu K, Park C, Li S, Lee KW, Liu H, He L, Soung NK, Ahn JS, Bode AM, Dong Z, Kim BY, Dong Z.(PubMed)
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