Herbal Aloe vera may be used for the prevention and treatment of prostate cancer with no side effects, some scientists suggested.
Prostate cancer is slow-growing cancer characterized by irregular cell growth in the prostate tissue.
Most cases of prostate cancer start in the cells on the surface of the inner lining tissue. However, at
the advanced stage, cancerous prostate cells can travel a distance away to infect other healthy tissue and organs, causing the secondary metastasis. Most often, prostate cancer spreads to the bones or lymph nodes.
Most prostate cancers may be detected during the physical (rectum) exams.
According to the statistic, 1 man in 9 will be diagnosed with prostate cancer during his lifetime. 6 cases in 10 are diagnosed in men aged 65 or older and the average age at the time of diagnosis is about 66.
The 5-year survival rate for most men with stage 0 and 1 prostate cancer is nearly 100%. Ninety-eight percent (98%) are alive after 10 years.
These results strongly indicated that men who are at a higher risk of prostate cancer due to family history and genetic proposition should have a prostate exam taken every year.
Besides aging, other most common risk factors of prostate cancer include family history, ethnicity, genetic preposition, exposure to agent orange and eating habits.
Dr. Wambui G. Gathirua-Mwangi, the lead author in the cancer team in the joint study led by the Indiana University, wrote, "Epidemiologic studies have overall showed that the habitual consumption of a diet high in saturated fat, well-done meats, and calcium is associated with an increased risk of advanced prostate cancer".
And, "measure the nutrients and their biochemical indicators, the risk of advanced prostate cancer, which is fatal and thus clinically significant, may be reduced by dietary modification or chemoprevention".
The finding strongly indicated a healthy diet high in fruits and vegetables and whole grain and low in
saturated and trans fat, red meat and processed foods have a decreased risk of prostate cancer.
Aloe Vera is species of succulent plant in the genus Aloe, belonging to the Family Xanthorrhoeaceae, native to Sudan. It has become very popular for commercial cultivation due to its health benefits.
The herbal plant has been used in herbal medicine in treating many kinds of disease, including wound, burn healing, minor skin infections, sebaceous cysts, diabetes, and elevated cholesterol, etc. It is also one of many popular herbs studied in scientific ways with some conflicting results.
The ten main areas of chemical constituents of Aloe vera include Aloe-Emodin, amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.
On finding a natural compound or ingredient for the treatment of prostate cancer with no side effects, researchers at the Korea Research Institute of Bioscience and Biotechnology evaluated phytochemical Aloe-emodin, a bioactive compound isolated from the Aloe vera against prostate cancer on the protein
Aloe-emodin inhibited both proliferation and anchorage-independent growth of PC3 cells.
The efficacy of the inhibited was found to involve proteins that exhibit androgen-refractory prostate cell proliferation and anchorage-independent growth through cancer cell metabolism.
Furthermore, Aloe-emodin demonstrated a significant effect against the activation of a protein (mTORC2) in stimulating the cancer cell proliferation and migration.
Interestingly, researchers also found that Aloe-emodin also inhibits the gene associated with tumor promoter, namely Protein kinase C alpha (PKCα).
Expression of protein kinase C alpha (PKCα) has a strong implication in cancer metastasis and poor prognosis.
In other words, Aloe-emodin displays significant anti-prostate cancer properties by inhibiting cancer cell proliferation, migration through binging to proteins associated with them.
In vivo, Aloe-emodin also exhibited tumor suppression effects in an athymic nude mouse model.
Dr. Liu K after taking into account co and confounders said, "aloe-emodin suppresses prostate cancer progression by targeting mTORC2".
Taken altogether, herbal Aloe vera may be considered a functional remedy for the prevention and combined with primary medicine for the treatment of prostate cancer with no side effect, pending to the confirmation of large sample size and multicenter human study.
Intake of supplement Aloe-emodin should be taken with extreme care to prevent overdoses induced acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
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Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2 by Liu K, Park C, Li S, Lee KW, Liu H, He L, Soung NK, Ahn JS, Bode AM, Dong Z, Kim BY, Dong Z.(PubMed)
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