Eye disease is a general term of conditions associated with the damage of the optic nerve and impaired vision, including disease of the cornea and macular degeneration.
People with eye disease in the early stage may not have any symptoms. However, depending on the severity and location that affects the vision, people with eye disease at the advanced stage may experience symptoms of acute eye pain, hazy, blurred, or double vision, seeing flashes of light or sudden bright floating spots.
If you have some of the aforementioned symptoms, you may have eye disease. Please make sure that you check with your doctor to rule out the possibility.
Most common eye problems are minor and will go away on their own such as red-eye and eye strain. However, some eye problems may require medical attention such as vision change.
According to the statistics, the financial burden of vision loss and eye diseases and vision disorders in the U.S. has taken a toll on health care costs. Approximately, over $130 billion a year are spent to treat eye disease.
Bilberry is a species of low-growing shrubs in the genus Vaccinium, belonging to the family Ericaceae, native to Northern Europe.
The plant has been used as herbs in traditional medicine for the treatment of acute and chronic diarrhea, gastritis, gastric ulcer, and duodenal ulcer, enterocolitis, ulcerative colitis, anemia, cystitis, kidney disease, and psoriasis, diabetes, etc.
In the urgency to find a natural source of the compound for the treatment of eye disease, particularly in the older population, researchers investigated the effects of bilberry anthocyanosides (Vaccinium myrtillus L.).
Bilberry anthocyanosides were found to promote rhodopsin, a biological pigment found in the rods of the retina synthesis and regeneration.
Moreover, the compounds increased retinal sensitivity to changes in light intensity and improved the visual acuity and dark adaptation and blood supply of the retina.
The findings support the regular use of bilberry anthocyanosides as a dietary source against the age-related macular degeneration, diabetic retinopathy, primary open-angle glaucoma, and other diseases.
Additionally, in order to reveal more information about bilberry bioactive compound property, researchers evaluated the effect of Ginkgo biloba extract (GBE) and anthocyanins on visual function in patients with normal tension glaucoma (NTG) based on the vascular theory of mechanisms of glaucomatous optic nerve damage.
332 subjects data (209 men and 123 women) treated with anthocyanins (n=132), GBE (n=103), or no medication (control, n=97) were reviewed.
According to the tested assays, the mean anthocyanin treatment duration was 24.32±10.43 (range, 6-53) months, and the mean GBE treatment duration was 23.81±10.36 months (range, 6-59) months.
After anthocyanin treatment, the mean best-corrected visual acuity (BCVA) for all eyes improved from 0.16 logMAR units, and Humphrey Visual Field (HVF) mean deviation improved from -6.44.
Dr. Shim SH, the lead scientist said, "These results suggest that anthocyanins and GBE may be helpful in improving visual function in some individuals with NTG".
Taken altogether, bilberry processed abundantly bioactive compound anthocyanin may be considered a functional remedy for the prevention and treatment of eye diseases, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) [Current data on the role of anthocyanosides and flavonoids in the treatment of eye diseases].[Article in Russian; Abstract available in Russian from the publisher] by Vorob'eva IV1, Vorob'eva IV. (PubMed)
(2) Ginkgo biloba extract and bilberry anthocyanins improve visual function in patients with normal tension glaucoma by Shim SH1, Kim JM, Choi CY, Kim CY, Park KH. (PubMed)
Friday, May 24, 2019
3,3'-Diindolylmethane, the Best Anti-inflammatory Bioactive Compound
Inflammation is a natural response of the immune system which tries to protect our body by destroying the harmful pathogens before they cause damage.
In the acute phase of infection, the immune system white blood cells in the first line defense stimulate the production of blood palette to cover the wound and the production of inflammatory cytokines to kill off micro-organisms, leading to symptoms of fever, redness, and swelling.
Overproduction of proinflammatory cytokines in some cases have been found to damage nearby healthy cells and tissues, causing the formation of scars.
In severe cases, a protein with duo functions in the production of pro and anti-inflammatory cytokines which produce anti-inflammatory cytokines under normal condition also switch to produce pro-inflammatory cytokines.
Most harmful pathogens are stopped at the acute phase of infection. However, if the immune first line of defense can not completely destroy the invaders within a period of 3 to 8 weeks, it will compromise, leading to low-grade chronic inflammation.
Diseases associated with low-grade chronic inflammation include diabetes, cardiovascular disease, and cancer.
Conventional treatment of acute phase inflammation is to manage inflammation and prevent the risk of long-term damage, including anti-inflammatory nonsteroidal anti-inflammatory drugs (NSAIDs) which can be bought without a prescription.
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
In the urgency of finding a potential compound which processes a strong anti-inflammatory activity, researchers examined the effects of 3,3'-Diindolylmethane (DIM), a condensation product of indole-3-carbinol, and a glucosinolate naturally occurring in Brassica genus vegetables.
The study carried out by differentiated the 3T3-L1 adipocytes in the co-cultured with RAW 264.7 macrophages and exposed to 20 µM, 40 µM and 60 µM DIM for 24 h followed by 100 nM insulin for 20 min.
According to the tested assays, DIM significantly (p<0.05) reduced the production and mRNA expression of proinflammatory cytokines (MCP-1, IL-6, and TNFα) in a concentration-dependent manner.
Injection of DIM was found to increase the expression of proteins involved in the positive regulation of metabolism and proliferation (IRS-1 pY612 and Akt-1/PKB pT308) through its anti-inflammatory properties.
In other words, DIM influences the glucose metabolic pathway by exerting an anti-inflammatory effect.
Dr.Lopez-Vazquez A, the lead scientist said, "The potential therapeutic benefits of DIM in the treatment of glucose metabolic disorders deserve further studies".
In order to reveal more information about DIM anti-inflammatory effects, researchers examined the dietary components found in cruciferous vegetables, on brain inflammation.
Administration of DIM suppressed lipopolysaccharide (LPS)-induced expression of reactive oxygen species and promoted the production of antioxidant enzymes in the host through inhibiting the microglial hyperactivation by attenuating inflammatory transcription factor NF-κB.
Furthermore, DIM protected primary cortical neurons from inflammatory toxicity induced by LPS.
In vivo model of neuroinflammation, DIM also suppressed LPS-induced brain inflammation in mouse hippocampus.
Based on the findings, Dr. Kim HW, the lead researchers said, "DIM may have beneficial potential against brain inflammation and neurodegenerative diseases through the negative regulation of the NF-κB signal pathway in microglia".
Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of diseases associated with chronic inflammation, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) IRS-1 pY612 and Akt-1/PKB pT308 Phosphorylation and Antiinflammatory Effect of Diindolylmethane in Adipocytes Cocultured with Macrophages by Lopez-Vazquez A1, Garcia-Banuelos JJ2, Gonzalez-Garibay AS1, Urzua-Lozano PE1, Del Toro-Arreola S1, Bueno-Topete MR1, Sanchez-Enriquez S3, Munoz-Valle JF4, Jave-Suarez LF5, Armendariz-Borunda J6, Bastidas-Ramirez BE. (PubMed)
(2) 3,3'-Diindolylmethane inhibits lipopolysaccharide-induced microglial hyperactivation and attenuates brain inflammation by Kim HW1, Kim J, Kim J, Lee S, Choi BR, Han JS, Lee KW, Lee HJ. (PubMed)
In the acute phase of infection, the immune system white blood cells in the first line defense stimulate the production of blood palette to cover the wound and the production of inflammatory cytokines to kill off micro-organisms, leading to symptoms of fever, redness, and swelling.
Overproduction of proinflammatory cytokines in some cases have been found to damage nearby healthy cells and tissues, causing the formation of scars.
In severe cases, a protein with duo functions in the production of pro and anti-inflammatory cytokines which produce anti-inflammatory cytokines under normal condition also switch to produce pro-inflammatory cytokines.
Most harmful pathogens are stopped at the acute phase of infection. However, if the immune first line of defense can not completely destroy the invaders within a period of 3 to 8 weeks, it will compromise, leading to low-grade chronic inflammation.
Diseases associated with low-grade chronic inflammation include diabetes, cardiovascular disease, and cancer.
Conventional treatment of acute phase inflammation is to manage inflammation and prevent the risk of long-term damage, including anti-inflammatory nonsteroidal anti-inflammatory drugs (NSAIDs) which can be bought without a prescription.
3,3'-Diindolylmethane or DIM are phytochemicals derived from the digestion of indole-3-carbinol, belonging to the group of Indoles, found abundantly in broccoli, Brussels sprouts, cabbage, and kale, etc.
In the urgency of finding a potential compound which processes a strong anti-inflammatory activity, researchers examined the effects of 3,3'-Diindolylmethane (DIM), a condensation product of indole-3-carbinol, and a glucosinolate naturally occurring in Brassica genus vegetables.
The study carried out by differentiated the 3T3-L1 adipocytes in the co-cultured with RAW 264.7 macrophages and exposed to 20 µM, 40 µM and 60 µM DIM for 24 h followed by 100 nM insulin for 20 min.
According to the tested assays, DIM significantly (p<0.05) reduced the production and mRNA expression of proinflammatory cytokines (MCP-1, IL-6, and TNFα) in a concentration-dependent manner.
Injection of DIM was found to increase the expression of proteins involved in the positive regulation of metabolism and proliferation (IRS-1 pY612 and Akt-1/PKB pT308) through its anti-inflammatory properties.
In other words, DIM influences the glucose metabolic pathway by exerting an anti-inflammatory effect.
Dr.Lopez-Vazquez A, the lead scientist said, "The potential therapeutic benefits of DIM in the treatment of glucose metabolic disorders deserve further studies".
In order to reveal more information about DIM anti-inflammatory effects, researchers examined the dietary components found in cruciferous vegetables, on brain inflammation.
Administration of DIM suppressed lipopolysaccharide (LPS)-induced expression of reactive oxygen species and promoted the production of antioxidant enzymes in the host through inhibiting the microglial hyperactivation by attenuating inflammatory transcription factor NF-κB.
Furthermore, DIM protected primary cortical neurons from inflammatory toxicity induced by LPS.
In vivo model of neuroinflammation, DIM also suppressed LPS-induced brain inflammation in mouse hippocampus.
Based on the findings, Dr. Kim HW, the lead researchers said, "DIM may have beneficial potential against brain inflammation and neurodegenerative diseases through the negative regulation of the NF-κB signal pathway in microglia".
Taken altogether, 3,3'-Diindolylmethane derived from the digestion of indole-3-carbinol may be considered a supplement for the prevention and treatment of diseases associated with chronic inflammation, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) IRS-1 pY612 and Akt-1/PKB pT308 Phosphorylation and Antiinflammatory Effect of Diindolylmethane in Adipocytes Cocultured with Macrophages by Lopez-Vazquez A1, Garcia-Banuelos JJ2, Gonzalez-Garibay AS1, Urzua-Lozano PE1, Del Toro-Arreola S1, Bueno-Topete MR1, Sanchez-Enriquez S3, Munoz-Valle JF4, Jave-Suarez LF5, Armendariz-Borunda J6, Bastidas-Ramirez BE. (PubMed)
(2) 3,3'-Diindolylmethane inhibits lipopolysaccharide-induced microglial hyperactivation and attenuates brain inflammation by Kim HW1, Kim J, Kim J, Lee S, Choi BR, Han JS, Lee KW, Lee HJ. (PubMed)
Whole Food Honey, the Natural Antibiotic with No Side Effects
Antibiotics are conventional medicines used for the treatment of microbial infection except for the virus. The aim of the medicines is to kill off the microbial pathogens that cause the disease.
However, epidemiological suggested that antibiotics also kill the good bacterias and cells in the host, leading to weakened body functioning, including the immune system.
Furthermore, overuse of antibiotics over the past many decades has also caused genetic mutation in the bacteria, inducing the bacterial resistance superbugs that have caused a resurgence in some illnesses.
Out of billions of bacteria existed in the world, only a few hundreds have been known to cause infectious diseases. And bacterial pneumonia was probably the leading cause of death among the elderly.
Bacteria after entering the body and found a specific site to incubate, at the time permitted also secret toxins to attack the cells in the area, leading to infection and signs and symptoms of an illness.
Most common symptoms of the acute phase of infection are associated with an immune system response by stimulating the production of pro-inflammatory cytokines with an aim to kill off the pathogens, including fever, malaise, headache, rash.
People with a weakened immune system such as elderly and taking immune suppressive medicines and immature immune system such as infants are prone to the bacterial infection.
Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.
The liquid is considered one of the healthy food for replacing the use of white sugar and artificial sweetener by many people.
With an aim to find a natural therapy to replace the antibiotic with no side effects, researchers examined the antimicrobial activity and composition of a locally produced Portobello honey (PBH) on three bacteria known to infect wounds, compared to Manuka honey (MH).
The study included selected honeys were tested at four concentrations: 75%, 50%, 10% and 1% (v/v) and compared with untreated control.
According to the tested assays, both honeys at 75% and 50% inhibited the majority of the three bacteria tested. However, the 10% PBH exhibited antimicrobial activity to a lesser extent than 10% MH.
Both honeys were acidic with pH 4, and both produced H2O2 .
The results suggested although both honeys exert the similar antibacterial effects, the MH has significantly higher levels of the polyphenols and antioxidant activity than PBH.
Also, in the comparison of the antibacterial property of other types of honey and Manuka honey, researchers showed that Manuka honey was the most effective against Staphylococcus aureus Oxa R and S. aureus Oxa S with a Minimum Inhibitory Concentration (MIC) of 6% and 7%, respectively, compared to the wild carrot honey with a MIC of 12%.
Furthermore, tested Manuka honey contained the highest content of polyphenols, with 899.09 ± 11.75 mg gallic acid/kg, whereas lavender honey had the lowest, with 111.42 ± 3.54 mg gallic acid/kg.
Dr. the lead scientist wrote in the final report, "The differences between honey samples in terms of antibacterial and antioxidant activity could be attributed to the natural variations in floral sources of nectar and the different locations".
In other words, the antibacterial effect of honeys probably is associated with the levels of polyphenols content.
Taken altogether, honey processed a high amount of polyphenols may be considered antibacterial infection remedies with no side effects, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anti-microbial activity and composition of manuka and portobello honey by Schneider M1, Coyle S, Warnock M, Gow I, Fyfe L. (PubMed)
(2) Antibacterial and antioxidant potency of floral honeys from different botanical and geographical origins by Alzahrani HA1, Alsabehi R, Boukraâ L, Abdellah F, Bellik Y, Bakhotmah BA. (PubMed)
However, epidemiological suggested that antibiotics also kill the good bacterias and cells in the host, leading to weakened body functioning, including the immune system.
Furthermore, overuse of antibiotics over the past many decades has also caused genetic mutation in the bacteria, inducing the bacterial resistance superbugs that have caused a resurgence in some illnesses.
Out of billions of bacteria existed in the world, only a few hundreds have been known to cause infectious diseases. And bacterial pneumonia was probably the leading cause of death among the elderly.
Bacteria after entering the body and found a specific site to incubate, at the time permitted also secret toxins to attack the cells in the area, leading to infection and signs and symptoms of an illness.
Most common symptoms of the acute phase of infection are associated with an immune system response by stimulating the production of pro-inflammatory cytokines with an aim to kill off the pathogens, including fever, malaise, headache, rash.
People with a weakened immune system such as elderly and taking immune suppressive medicines and immature immune system such as infants are prone to the bacterial infection.
Honey, the rich golden liquid is the miraculous product made by bees using nectar from flowers.
The liquid is considered one of the healthy food for replacing the use of white sugar and artificial sweetener by many people.
With an aim to find a natural therapy to replace the antibiotic with no side effects, researchers examined the antimicrobial activity and composition of a locally produced Portobello honey (PBH) on three bacteria known to infect wounds, compared to Manuka honey (MH).
The study included selected honeys were tested at four concentrations: 75%, 50%, 10% and 1% (v/v) and compared with untreated control.
According to the tested assays, both honeys at 75% and 50% inhibited the majority of the three bacteria tested. However, the 10% PBH exhibited antimicrobial activity to a lesser extent than 10% MH.
Both honeys were acidic with pH 4, and both produced H2O2 .
The results suggested although both honeys exert the similar antibacterial effects, the MH has significantly higher levels of the polyphenols and antioxidant activity than PBH.
Also, in the comparison of the antibacterial property of other types of honey and Manuka honey, researchers showed that Manuka honey was the most effective against Staphylococcus aureus Oxa R and S. aureus Oxa S with a Minimum Inhibitory Concentration (MIC) of 6% and 7%, respectively, compared to the wild carrot honey with a MIC of 12%.
Furthermore, tested Manuka honey contained the highest content of polyphenols, with 899.09 ± 11.75 mg gallic acid/kg, whereas lavender honey had the lowest, with 111.42 ± 3.54 mg gallic acid/kg.
Dr. the lead scientist wrote in the final report, "The differences between honey samples in terms of antibacterial and antioxidant activity could be attributed to the natural variations in floral sources of nectar and the different locations".
In other words, the antibacterial effect of honeys probably is associated with the levels of polyphenols content.
Taken altogether, honey processed a high amount of polyphenols may be considered antibacterial infection remedies with no side effects, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Anti-microbial activity and composition of manuka and portobello honey by Schneider M1, Coyle S, Warnock M, Gow I, Fyfe L. (PubMed)
(2) Antibacterial and antioxidant potency of floral honeys from different botanical and geographical origins by Alzahrani HA1, Alsabehi R, Boukraâ L, Abdellah F, Bellik Y, Bakhotmah BA. (PubMed)
Thursday, May 23, 2019
Herbal Artichoke, the Best Anti-Aging Functional Remedy
Skin aging is a natural process which can not be stopped. However, some people may look younger compared to their biological age.
According to the prominent oxidative stress theory, long-term accumulation of cells damage due to overexpression of free radicals in the skin can lead to early skin aging.
The joint study led by the University of Texas Health Science Center at San Antonio suggested, alterations in oxidative damage/stress also play a role in aging. Rodents with resistance to oxidative stress (and in some cases reduced oxidative damage to macromolecules) showed an increased lifespan, compared to oxidative stress control.
Some researchers suggested that genetic preposition may play a critical role in the promotion of delayed aging. Dr. Viviana I Pérez, the lead scientist in the study of free radical theory wrote, "Because only one (the deletion of the Sod1 gene) of the 18 genetic manipulations we studied had an effect on lifespan".
Regardless of free radical or other theories associated with the aging processes, there are many risk factors that can lead to reduced life span and delayed the skin aging process, even in people with a longevity gene.
In other words, long-term unhealthy lifestyle such as excessive alcohol drinking, substances abuse, smoking, physical inactivity not only can reduce the gene effect on longevity but also increase the risk of early skin aging and shorten the proposed life span.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as liver protective and detoxified agent, and for the treatment of digestive disorders, abdominal pain gas and bloating, etc.
Researchers on the finding a natural therapeutic which processed antiaging property investigated the anti-age effect of a polyphenolic artichoke extract on endothelial cells.
Injection of the extract showed a significant anti-aging activity by exhibiting the important molecular markers responsible for the microcirculation and vasodilatation of endothelial cells, through its anti-inflammatory function, and protecting the lymphatic vessels from oxidative damage by ROS formation, and enhancing the cellular cohesion by reinforcing the tight junction complex.
In other words, the polyphenolic artichoke extracts exhibited anti-age effect against the skin and subcutaneous tissue damage caused by overexpression of proinflammatory cytokines associated with the production of free radical and depletion of antioxidant enzymes produced by the host.
The anti-aging efficacy was attributed to the combined activity of constituents found in the herbal medicine, including 87% of chlorogenic, 3,5-O-dicaffeoylquinic, and 1,5-O-dicaffeoylquinic acids.
Furthermore, polyphenolic artichoke extract improved the expression of genes involved in anti-aging mechanisms.
On human subjects, an artichoke extract cosmetic formulation also reduced 19.74% of roughness and enhanced 11.45% of elasticity, compared to a placebo cream.
Furthermore, in UVB-induced photoaging, researchers examined antioxidant activity of Cynaropicrin (Cyn), a sesquiterpene lactone, and major bioactive phytochemical in the artichoke.
Cynaropicrin (Cyn) attenuated UVB-induced oxidative stress by activating the AhR-Nrf2-Nqo1 pathway associated with the production of antioxidants and anti-inflammatory factors against oxidative stress.
In other words, in anti-aging perspective, Cyn not only actively inhibited the generation of reactive oxygen species from keratinocytes irradiated with ultraviolet B (UVB), but also the production of proinflammatory cytokines such as interleukin 6 and tumor necrosis factor-α from UVB-treated keratinocytes.
Taken altogether, artichoke processed high amounts of bioactive compounds may be used as a functional antiaging remedy with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Artichoke Polyphenols Produce Skin Anti-Age Effects by Improving Endothelial Cell Integrity and Functionality by D'Antuono I1, Carola A2, Sena LM3, Linsalata V4, Cardinali A5, Logrieco AF6, Colucci MG7,8, Apone F. (PubMed)
(2) Cynaropicrin attenuates UVB-induced oxidative stress via the AhR-Nrf2-Nqo1 pathway byTakei K1, Hashimoto-Hachiya A1, Takahara M1, Tsuji G1, Nakahara T2, Furue M. (PubMed)
(3) Is the Oxidative Stress Theory of Aging Dead? by Viviana I Pérez,1,2 Alex Bokov,1,3 Holly Van Remmen,1,2,4,6 James Mele,4 Qitao Ran,1,2Yuji Ikeno,1,5,6 and Arlan Richardson. (PMC)
According to the prominent oxidative stress theory, long-term accumulation of cells damage due to overexpression of free radicals in the skin can lead to early skin aging.
The joint study led by the University of Texas Health Science Center at San Antonio suggested, alterations in oxidative damage/stress also play a role in aging. Rodents with resistance to oxidative stress (and in some cases reduced oxidative damage to macromolecules) showed an increased lifespan, compared to oxidative stress control.
Some researchers suggested that genetic preposition may play a critical role in the promotion of delayed aging. Dr. Viviana I Pérez, the lead scientist in the study of free radical theory wrote, "Because only one (the deletion of the Sod1 gene) of the 18 genetic manipulations we studied had an effect on lifespan".
Regardless of free radical or other theories associated with the aging processes, there are many risk factors that can lead to reduced life span and delayed the skin aging process, even in people with a longevity gene.
In other words, long-term unhealthy lifestyle such as excessive alcohol drinking, substances abuse, smoking, physical inactivity not only can reduce the gene effect on longevity but also increase the risk of early skin aging and shorten the proposed life span.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as liver protective and detoxified agent, and for the treatment of digestive disorders, abdominal pain gas and bloating, etc.
Researchers on the finding a natural therapeutic which processed antiaging property investigated the anti-age effect of a polyphenolic artichoke extract on endothelial cells.
Injection of the extract showed a significant anti-aging activity by exhibiting the important molecular markers responsible for the microcirculation and vasodilatation of endothelial cells, through its anti-inflammatory function, and protecting the lymphatic vessels from oxidative damage by ROS formation, and enhancing the cellular cohesion by reinforcing the tight junction complex.
In other words, the polyphenolic artichoke extracts exhibited anti-age effect against the skin and subcutaneous tissue damage caused by overexpression of proinflammatory cytokines associated with the production of free radical and depletion of antioxidant enzymes produced by the host.
The anti-aging efficacy was attributed to the combined activity of constituents found in the herbal medicine, including 87% of chlorogenic, 3,5-O-dicaffeoylquinic, and 1,5-O-dicaffeoylquinic acids.
Furthermore, polyphenolic artichoke extract improved the expression of genes involved in anti-aging mechanisms.
On human subjects, an artichoke extract cosmetic formulation also reduced 19.74% of roughness and enhanced 11.45% of elasticity, compared to a placebo cream.
Furthermore, in UVB-induced photoaging, researchers examined antioxidant activity of Cynaropicrin (Cyn), a sesquiterpene lactone, and major bioactive phytochemical in the artichoke.
Cynaropicrin (Cyn) attenuated UVB-induced oxidative stress by activating the AhR-Nrf2-Nqo1 pathway associated with the production of antioxidants and anti-inflammatory factors against oxidative stress.
In other words, in anti-aging perspective, Cyn not only actively inhibited the generation of reactive oxygen species from keratinocytes irradiated with ultraviolet B (UVB), but also the production of proinflammatory cytokines such as interleukin 6 and tumor necrosis factor-α from UVB-treated keratinocytes.
Taken altogether, artichoke processed high amounts of bioactive compounds may be used as a functional antiaging remedy with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Artichoke Polyphenols Produce Skin Anti-Age Effects by Improving Endothelial Cell Integrity and Functionality by D'Antuono I1, Carola A2, Sena LM3, Linsalata V4, Cardinali A5, Logrieco AF6, Colucci MG7,8, Apone F. (PubMed)
(2) Cynaropicrin attenuates UVB-induced oxidative stress via the AhR-Nrf2-Nqo1 pathway byTakei K1, Hashimoto-Hachiya A1, Takahara M1, Tsuji G1, Nakahara T2, Furue M. (PubMed)
(3) Is the Oxidative Stress Theory of Aging Dead? by Viviana I Pérez,1,2 Alex Bokov,1,3 Holly Van Remmen,1,2,4,6 James Mele,4 Qitao Ran,1,2Yuji Ikeno,1,5,6 and Arlan Richardson. (PMC)
Wednesday, May 22, 2019
Whole Food Ginger, the Natural Treatment of Premenstrual Syndrome With No Side Effects, according to A Human Study
Scientists may have found a natural kitchen spice for the treatment of premenstrual syndrome symptoms (PMS) with no side effects.
Premenstrual syndrome is a condition caused by the faulty function of the ovaries related to the women's menstrual cycle, due to hormone fluctuation in one to two weeks before menstruation and then declines when the period starts.
PMS affects over 70% to 90% of women in the US compared to a lesser affection to women in Southeast Asia because of the different living style and social structure.
Most common symptoms of PMS include fatigue, fluid retention breast tenderness, acne, sleep disturbances and appetite changes with overeating or food cravings.
PMS can be classified into 4 types, categorizing by the symptoms including1. Anxiety
Anxiety is a common symptom for women with PMS, caused by a hormone imbalance between estrogen and progesterone(1). Most women with PMS is found to have a very high level of estrogen and low levels of progesterone(4) before menstruation.
Withdrawal from chronic exposure to the female sex steroid progesterone (P) may also contribute to the occurrence of PMS anxiety(2).
2. Craving
Some women with PMS may experience the symptom of food craving, caused by an abnormal liver function in carbohydrate synthesis due to dietary habits(6) and abnormal levels of serotonin(10)(8).
Other theories suggest that when a woman under stress before period, she may grasp for everything which makes her feel more comfortable(7).
3. Hyperhydration(11)
Breast tenderness and water retention(12) are always a problem for some women with PMS. Breast tenderness is caused by overproduction of prolactin due to the abnormal function of the pituitary gland(13). Water retention is either caused by overproduction of prolactin-induced renal sodium and potassium excretion(16) or abnormal function of lymphatic function(14)(15).
4. Depression
Researchers found that women with the symptom of depression always have unbalanced levels of estrogen(3) and progesterone as a result of liver abnormal function in fat and protein metabolism(5). This unbalance also induces nervous tension, that causes nervous disorder including depression(3).
Conventionally, selective serotonin reuptake inhibitors (SSRIs), nonsteroidal anti-inflammatory drugs (NSAIDs), diuretics and hormonal contraceptives. are the most common medicine used for the treatment of PMS, depending on the types of symptom.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on finding a natural compound for the treatment of premenstrual syndrome (PMS), evaluated the effects of ginger on the severity of symptoms of PMS.
The clinical trial, double-blinded work, included 70 participants were randomly allocated to intervention (n = 35) and control (n = 35) groups. All persons suffering from PMS were asked to complete the daily record scale questionnaire for two consecutive cycles before treatment.
According to the returned questionnaire, there were no significant differences between the mean scores of PMS symptoms in the two groups before intervention.
Each participant received two ginger capsules daily from seven days before menstruation to three days after menstruation for three cycles and they recorded the severity of the symptoms by daily record scale in the questionnaire.
By comparing the date 1, 2, and 3 months after intervention, the ginger treatment group showed a significant improvement of the PMS symptoms compared to control.
Dr. Khayat S, and colleagues wrote in the final report, "Based on the results of this study, maybe ginger is effective in the reduction of severity of mood and physical and behavioral symptoms of PMS and we suggest ginger as a treatment for PMS".
Take all together, ginger may be considered a functional alternative for the treatment of premenstrual syndrome (PMS) pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Effect of treatment with ginger on the severity of premenstrual syndrome symptoms by Khayat S1, Kheirkhah M2, Behboodi Moghadam Z3, Fanaei H4, Kasaeian A5, Javadimehr M. (PubMed)
Premenstrual syndrome is a condition caused by the faulty function of the ovaries related to the women's menstrual cycle, due to hormone fluctuation in one to two weeks before menstruation and then declines when the period starts.
PMS affects over 70% to 90% of women in the US compared to a lesser affection to women in Southeast Asia because of the different living style and social structure.
Most common symptoms of PMS include fatigue, fluid retention breast tenderness, acne, sleep disturbances and appetite changes with overeating or food cravings.
PMS can be classified into 4 types, categorizing by the symptoms including1. Anxiety
Anxiety is a common symptom for women with PMS, caused by a hormone imbalance between estrogen and progesterone(1). Most women with PMS is found to have a very high level of estrogen and low levels of progesterone(4) before menstruation.
Withdrawal from chronic exposure to the female sex steroid progesterone (P) may also contribute to the occurrence of PMS anxiety(2).
2. Craving
Some women with PMS may experience the symptom of food craving, caused by an abnormal liver function in carbohydrate synthesis due to dietary habits(6) and abnormal levels of serotonin(10)(8).
Other theories suggest that when a woman under stress before period, she may grasp for everything which makes her feel more comfortable(7).
3. Hyperhydration(11)
Breast tenderness and water retention(12) are always a problem for some women with PMS. Breast tenderness is caused by overproduction of prolactin due to the abnormal function of the pituitary gland(13). Water retention is either caused by overproduction of prolactin-induced renal sodium and potassium excretion(16) or abnormal function of lymphatic function(14)(15).
4. Depression
Researchers found that women with the symptom of depression always have unbalanced levels of estrogen(3) and progesterone as a result of liver abnormal function in fat and protein metabolism(5). This unbalance also induces nervous tension, that causes nervous disorder including depression(3).
Conventionally, selective serotonin reuptake inhibitors (SSRIs), nonsteroidal anti-inflammatory drugs (NSAIDs), diuretics and hormonal contraceptives. are the most common medicine used for the treatment of PMS, depending on the types of symptom.
Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.
The root has been used in traditional and Chinese medicine for the treatment of dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.
Researchers on finding a natural compound for the treatment of premenstrual syndrome (PMS), evaluated the effects of ginger on the severity of symptoms of PMS.
The clinical trial, double-blinded work, included 70 participants were randomly allocated to intervention (n = 35) and control (n = 35) groups. All persons suffering from PMS were asked to complete the daily record scale questionnaire for two consecutive cycles before treatment.
According to the returned questionnaire, there were no significant differences between the mean scores of PMS symptoms in the two groups before intervention.
Each participant received two ginger capsules daily from seven days before menstruation to three days after menstruation for three cycles and they recorded the severity of the symptoms by daily record scale in the questionnaire.
By comparing the date 1, 2, and 3 months after intervention, the ginger treatment group showed a significant improvement of the PMS symptoms compared to control.
Dr. Khayat S, and colleagues wrote in the final report, "Based on the results of this study, maybe ginger is effective in the reduction of severity of mood and physical and behavioral symptoms of PMS and we suggest ginger as a treatment for PMS".
Take all together, ginger may be considered a functional alternative for the treatment of premenstrual syndrome (PMS) pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.
Sources
(1) Effect of treatment with ginger on the severity of premenstrual syndrome symptoms by Khayat S1, Kheirkhah M2, Behboodi Moghadam Z3, Fanaei H4, Kasaeian A5, Javadimehr M. (PubMed)
Turmeric's Bioactive Compound Curcumin Protects Diabetics Against Diabetic cardiomyopathy
Diabetic cardiomyopathy is a complication found in patients with diabetes associated with reducing the heart function in circulating blood through the body, leading to heart failure and increased the accumulation of fluid in the lungs.
Diabetic cardiomyopathy is classified into different types, depending on the damage that has been affected, including
* Microangiopathy is a disorder that affects small blood vessels, leading to impaired myocardial blood flow reserve.
* Autonomic neuropathy is a disorder that affects the nerves that manage everyday body functions, leading to abnormal blood pressure, heart rate.
* Endothelial dysfunction is a disorder associated with the damage of vascular endothelium. The condition is considered an early event of cardiovascular disease.
Most common causes of diabetic cardiomyopathy are myocardial dysfunction in the absence of overt clinical coronary artery disease, valvular disease, and other conventional cardiovascular risk factors, such as hypertension and dyslipidemia.
At the early stage, most patients with diabetic cardiomyopathy are asymptomatic. However, mild left ventricular diastolic dysfunction with little effect on ventricular filling and concomitant hypertension or coronary artery disease has been found to be the early indication of diabetic cardiomyopathy in patients with diabetes.
Epidemiologically, the most common risk factors that increase the risk of diabetic cardiomyopathy. are insulin resistance, hyperinsulinemia, and hyperglycemia.
Conventionally, as of today, there is no effective treatment of diabetic cardiomyopathy. Medication used for the treatment of the condition is focusing on glycemic control and management of heart failure symptoms.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to find a potential ingredient for the treatment of diabetic cardiomyopathy(DCM), researchers examined the effect of curcumin on modulating DCM and the mechanisms involved.
The study included experimental diabetic rat model induced by a low dose of streptozotocin(STZ) combined with high energy intake on rats, followed by curcumin orally administrated at a dose of 100 or 200 mg · kg(-1) · d(-1), respectively.
Before treatment of curcumin, induced DCM rats showed a declined systolic myocardial performance associated with myocardial hypertrophy and fibrosis accompanied by the metabolism abnormalities, aberrant myocardial enzymes, and increased AGEs (advanced glycation end products) accumulation.
Increased levels of ROS and depletion of antioxidant enzymes were also found in the rat before pretreatment with curcumin, observed by increased oxidative stress markers.
Futhermore, levels of pro-apoptotic proteins and proinflammatory cytokines were also found to significantly increase in DCM rats.
After injection of curcumin, researchers found that remarkably, the bioactive compound attenuated myocardial dysfunction, cardiac fibrosis, AGEs accumulation, oxidative stress, inflammation and apoptosis in the heart of diabetic rats.
In other words, curcumin protected the heart of DCM rats against the onset of diabetic cardiomyopathy(DCM).
Based on the results, researchers said, "these results suggest that curcumin may have great therapeutic potential in the treatment of DCM, and perhaps other cardiovascular disorders, by attenuating fibrosis, oxidative stress, inflammation, and cell death".
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered a supplement for the prevention and treatment of diabetic cardiomyopathy, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin, A Polyphenolic Curcuminoid With Its Protective Effects and Molecular Mechanisms in Diabetes and Diabetic Cardiomyopathy by Zheng J1, Cheng J2, Zheng S3, Feng Q3, Xiao X. (PubMed)
(2) Curcumin alleviates diabetic cardiomyopathy in experimental diabetic rats by Yu W1, Wu J, Cai F, Xiang J, Zha W, Fan D, Guo S, Ming Z, Liu C. (PubMed)
Diabetic cardiomyopathy is classified into different types, depending on the damage that has been affected, including
* Microangiopathy is a disorder that affects small blood vessels, leading to impaired myocardial blood flow reserve.
* Autonomic neuropathy is a disorder that affects the nerves that manage everyday body functions, leading to abnormal blood pressure, heart rate.
* Endothelial dysfunction is a disorder associated with the damage of vascular endothelium. The condition is considered an early event of cardiovascular disease.
Most common causes of diabetic cardiomyopathy are myocardial dysfunction in the absence of overt clinical coronary artery disease, valvular disease, and other conventional cardiovascular risk factors, such as hypertension and dyslipidemia.
At the early stage, most patients with diabetic cardiomyopathy are asymptomatic. However, mild left ventricular diastolic dysfunction with little effect on ventricular filling and concomitant hypertension or coronary artery disease has been found to be the early indication of diabetic cardiomyopathy in patients with diabetes.
Epidemiologically, the most common risk factors that increase the risk of diabetic cardiomyopathy. are insulin resistance, hyperinsulinemia, and hyperglycemia.
Conventionally, as of today, there is no effective treatment of diabetic cardiomyopathy. Medication used for the treatment of the condition is focusing on glycemic control and management of heart failure symptoms.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to find a potential ingredient for the treatment of diabetic cardiomyopathy(DCM), researchers examined the effect of curcumin on modulating DCM and the mechanisms involved.
The study included experimental diabetic rat model induced by a low dose of streptozotocin(STZ) combined with high energy intake on rats, followed by curcumin orally administrated at a dose of 100 or 200 mg · kg(-1) · d(-1), respectively.
Before treatment of curcumin, induced DCM rats showed a declined systolic myocardial performance associated with myocardial hypertrophy and fibrosis accompanied by the metabolism abnormalities, aberrant myocardial enzymes, and increased AGEs (advanced glycation end products) accumulation.
Increased levels of ROS and depletion of antioxidant enzymes were also found in the rat before pretreatment with curcumin, observed by increased oxidative stress markers.
Futhermore, levels of pro-apoptotic proteins and proinflammatory cytokines were also found to significantly increase in DCM rats.
After injection of curcumin, researchers found that remarkably, the bioactive compound attenuated myocardial dysfunction, cardiac fibrosis, AGEs accumulation, oxidative stress, inflammation and apoptosis in the heart of diabetic rats.
In other words, curcumin protected the heart of DCM rats against the onset of diabetic cardiomyopathy(DCM).
Based on the results, researchers said, "these results suggest that curcumin may have great therapeutic potential in the treatment of DCM, and perhaps other cardiovascular disorders, by attenuating fibrosis, oxidative stress, inflammation, and cell death".
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered a supplement for the prevention and treatment of diabetic cardiomyopathy, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin, A Polyphenolic Curcuminoid With Its Protective Effects and Molecular Mechanisms in Diabetes and Diabetic Cardiomyopathy by Zheng J1, Cheng J2, Zheng S3, Feng Q3, Xiao X. (PubMed)
(2) Curcumin alleviates diabetic cardiomyopathy in experimental diabetic rats by Yu W1, Wu J, Cai F, Xiang J, Zha W, Fan D, Guo S, Ming Z, Liu C. (PubMed)
Tuesday, May 21, 2019
Herbal Artichoke Enhanced Nonpathogenic Intestinal Microflora for the Promotion of Digestive Health
Gut microbiota or gastrointestinal microbiota is the complex community of over 10 trillion microorganisms living in our digestive tracts.
Use of antibiotics, diet, drugs, may alter the composition of the microbiota.
Under the normal condition, in healthy individuals, gut microbiota plays a critical role in the modulation of the immune, metabolic and neurobehavioral traits.
In Immunity, gut microbiota stimulates the immune system protective responses to pathogens and the maintenance of tolerance to innocuous antigens.
In metabolism, gut microbiota improve glucose tolerance, mipoprotein profile and atherosclerotic plaque development.
In neurological disease, gut microbiota improved the neuropsychiatric conditions, including depression, autism and Parkinson’s disease.
In other words, the balanced gut microbiota has a strong impact on the protection of our body against abnormal metabolism, infectious diseases, and loss or death of neurons in the initiation of diseases of the central nervous system.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on the finding a natural therapeutics for the improvement nonpathogenic intestinal microflora investigated the dried Jerusalem artichoke(JA) effects on microflora and short-chain fatty acids (SCFA) in the hindgut.in male pigs 1 week fed with JA before slaughter.
The study included 5 experimental groups (n = 11) given different dietary treatments 7 days before slaughter: negative control (basal diet), positive control (basal diet + 9% chicory-inulin), basal diet + 4.1% Jerusalem artichoke, basal diet + 8.1% Jerusalem artichoke and basal diet + 12.2% Jerusalem artichoke.
Increasing levels of Jerusalem artichoke to entire male pigs reduced skatole, a mildly toxic compound in digesta from colon and in feces and level of Clostridium perfringens, type of bad bacterias in the gut in both colon and rectum.
Furthermore, injection of JA also increased the total amount of SCFA (linear, P < 0.05), acetic acid (linear, P < 0.05) and valerianic acid (linear, P < 0.01) produced by the friendly bacteria in your gut in feces.
JA improved intestinal microflora by reducing skatole levels through decreasing in C. perfringens and the increase in SCFA with a subsequent reduction in pH.
Taken altogether, artichoke may be considered a functional formula for the improvement of the intestinal microflora, with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Feeding Jerusalem artichoke reduced skatole level and changed intestinalmicrobiota in the gut of entire male pigs by Vhile SG1, Kjos NP, Sørum H, Overland M. (PubMed)
(2) The effects of inulin, dried Jerusalem artichoke tuber and a multispecies probiotic preparation on microbiota ecology and immune status of the large intestine in young pigs by Barszcz M1, Taciak M1, Skomiał J. (PubMed)
Use of antibiotics, diet, drugs, may alter the composition of the microbiota.
Under the normal condition, in healthy individuals, gut microbiota plays a critical role in the modulation of the immune, metabolic and neurobehavioral traits.
In Immunity, gut microbiota stimulates the immune system protective responses to pathogens and the maintenance of tolerance to innocuous antigens.
In metabolism, gut microbiota improve glucose tolerance, mipoprotein profile and atherosclerotic plaque development.
In neurological disease, gut microbiota improved the neuropsychiatric conditions, including depression, autism and Parkinson’s disease.
In other words, the balanced gut microbiota has a strong impact on the protection of our body against abnormal metabolism, infectious diseases, and loss or death of neurons in the initiation of diseases of the central nervous system.
Artichoke is a perennial thistle of Cynara cardunculus species of the Cynara genus, belonging to the family Carduoideae native to Southern Europe around the Mediterranean.
The herbal plant has been used in traditional medicine as liver protective and detoxified agent, and to treat digestive disorders, abdominal pain gas and bloating, etc.
Researchers on the finding a natural therapeutics for the improvement nonpathogenic intestinal microflora investigated the dried Jerusalem artichoke(JA) effects on microflora and short-chain fatty acids (SCFA) in the hindgut.in male pigs 1 week fed with JA before slaughter.
The study included 5 experimental groups (n = 11) given different dietary treatments 7 days before slaughter: negative control (basal diet), positive control (basal diet + 9% chicory-inulin), basal diet + 4.1% Jerusalem artichoke, basal diet + 8.1% Jerusalem artichoke and basal diet + 12.2% Jerusalem artichoke.
Increasing levels of Jerusalem artichoke to entire male pigs reduced skatole, a mildly toxic compound in digesta from colon and in feces and level of Clostridium perfringens, type of bad bacterias in the gut in both colon and rectum.
Furthermore, injection of JA also increased the total amount of SCFA (linear, P < 0.05), acetic acid (linear, P < 0.05) and valerianic acid (linear, P < 0.01) produced by the friendly bacteria in your gut in feces.
JA improved intestinal microflora by reducing skatole levels through decreasing in C. perfringens and the increase in SCFA with a subsequent reduction in pH.
Taken altogether, artichoke may be considered a functional formula for the improvement of the intestinal microflora, with no side effects, pending to the validation of larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Feeding Jerusalem artichoke reduced skatole level and changed intestinalmicrobiota in the gut of entire male pigs by Vhile SG1, Kjos NP, Sørum H, Overland M. (PubMed)
(2) The effects of inulin, dried Jerusalem artichoke tuber and a multispecies probiotic preparation on microbiota ecology and immune status of the large intestine in young pigs by Barszcz M1, Taciak M1, Skomiał J. (PubMed)
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