Green tea is found to consist of a therapeutic and sustainable effect in reduced risk and progression of lifestyle diseases, some scientists postulated
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.
Lifestyle diseases are a class of diseases associated with the way a person or group of people lives, including atherosclerosis, heart disease, and stroke; obesity and type 2 diabetes....and diseases precipitated by smoking and alcohol and drug abuse.
Epidemiological studies suggested that lifestyle-related diseases may be preventable with the change of lifestyle accompanied by the intake of some nontoxic agents.
Differentiation of the effect of green tea in attenuated risk and treatment of lifestyle-related diseases was found to associate to some mechanisms involving numbers of aspect, particularly, in gene facilitation.
In animal model, green tea administration inhibited risk and symptoms and progression of chronic inflammatory diseases such as rheumatoid arthritis and multiple sclerosis, through regulation of tumor necrosis factor (TNF-alpha) gene in expression of inflammatory cytokines in promoted systematic inflammation in the acute phase of infection caused by damage and injure tissues, in modulated the activation of NF-kappaB signalling pathway related to cellular response in induction of anti and pro-inflammatory stimulation and transcription factor complex (AP-1) in initiation of inflammation against foreign invasion.
The inhibition of inflammatory cytokines expression reduced symptoms of pain, reddish skin, swelling without limiting the protective effect of the immune system to prevent damage tissues against the invasion of foreign substances.
Further analysis of chronic inflammatory diseases, in transgenic mice model with human idiopathic pulmonary fibrosis suggested that injection of green tea in 4 months demonstrated a significant activity in ameliorated overexpression of TNF-alpha in stimulated production of pro-inflammatory cytokines and interleukin (IL)-6 in initiated inflammatory expression in cellular defense in response to infections and tissue injuries in the lung.
In lifestyle-related diseases of cardiovascular disease, intake of green tea beverage or extract expressed a significant reduction in serum total cholesterol and LDL-cholesterol concentrations, without affecting the levels of HDL-cholesterol.
Additionally, in patients with type 2 diabetes mellitus, green tea extract catechin injection improved fasting glucose levels without affecting the hemoglobin A1c (HbA1c) level, which is an predictor of type 2 diabetes onset and green tea consumed 5 or more cups per day was associated with a strongly and positively inverse association to risk of type 2 diabetes mellitus.
.
More amazingly, after taking into account of other confounders, Dr. Sueoka E, the lead scientist suggested that intake of green tea, containing catechins and caffeine, 5 or more cups per day exhibited a potential and therapeutic effect for bodyweight management, without going into details.
According to the prospective cohort study in Saitama Prefecture, Japan, green tea injection of over 10 cups per day, displayed a substantial effect in decreased relative risk of death from all causes in patients with cardiovascular disease, particularly, in stroke mortality.
Take together, there is no doubt that green tea with abundantly bioactive phytochemicals may be considered as a functional food to reduced risk, progression, and treatment of lifestyle-related disease, but a change of lifestyle is always recommended.
For More information about yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.Sources
(1) Human clinical studies of tea polyphenols in allergy or life style-related diseases by Maeda-Yamamoto M1.(PubMed)
(2) A new function of green tea: prevention of lifestyle-related diseases by Sueoka N1, Suganuma M, Sueoka E, Okabe S, Matsuyama S, Imai K, Nakachi K, Fujiki H.(PubMed)
Friday, August 9, 2019
Herbal Turmeric Protects the Cells Integrity and Viability Against Arsenic Exposure
Arsenic is a toxic chemical with atomic number 33 found in many minerals, usually in combination with other chemicals, including sulfur and metals.
Arsenic exposure can be acute or chronic
* Acute arsenic toxicity is caused by arsenic toxicity that induces symptoms of nausea, vomiting, abdominal pain, and severe diarrhea. In severe cases, the acute condition also causes encephalopathy and peripheral neuropathy.
* Chronic arsenic toxicity results in multisystem disease.
Some studies suggested that inorganic arsenic has been found to act as a human carcinogen in the initiation or progression of skin, lung, and bladder cancer.
Chronic arsenic toxicity is also associated with liver and prostate cancer.
Recent studies suggested chronic arsenic toxicity also have a positive link to diabetes, neurological effects, cardiac disorders, and reproductive organs.
In skin cancer, exposure to trivalent arsenite was found to be associated with the occurrence of UV-induced skin cancers.
In Lung cancer, according to some studies, the risk of lung cancer is consistently higher in groups exposed to arsenic compared to a group that does not.
In bladder cancer, a recent study suggested that exposure to low concentrations of arsenic is related to bladder cancer because of potentially insufficient statistical power and errors in the classification of exposure status.
In liver cancer, risk of the liver is increased substantially at an arsenic concentration that is above 0.64, according to the 20-year retrospective cohort study on liver cancer patients (802 male and 301 female) from 138 communities in Taiwan suggested.
In prostate cancer, the relative odds ratio is increased depending on the concentration of arsenic concentration.
In other diseases
* Neurological disease
Risk of neurological disease is directly associated with the arsenic concentration, including neurobehavioral abnormalities during puberty, and neurobehavioral changes as an adult.
* Diabetes
The link of arsenic exposure and the incidence of diabetes has been reported between type 2 diabetes occurring in obese individuals aged 40 years or older on inorganic arsenic exposure.
* Skin disorder
Exposure to various concentrations of arsenic promotes skin cancer risk and is related to disorders in the prodromal phases of skin cancer.
* In cardiovascular disease
Arsenic affects thrombocytes in the initiation of cardiovascular diseases.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a potential compound for the treatment of diseases associated with arsenic toxicity, researchers examined the effects of curcumin on DNA damage caused by arsenic.
In peripheral blood lymphocytes, from a healthy donor, DNA damage induced by arsenic was significantly reduced by curcumin, observed by the interaction of lymphocytes pre-incubated with curcumin prior to arsenic insult.
Furthermore, arsenic caused DNA damage by the generation of reactive oxygen species (ROS) and enhancement of lipid peroxidation level was inhibited by the administration of curcumin by increasing the level of phase II detoxification enzymes like catalase, superoxide dismutase, and glutathione peroxidase.
Moreover, injection of curcumin also enhanced the DNA repair activity against arsenic-induced damage, observed by the increased expression of the polymerase, a repair enzyme.
Based on the finding, Dr. Mukherjee S, the lead scientist said, "curcumin has a significant role in confronting the deleterious effect caused by arsenic, which could be an economic model of arsenic mitigation".
In the joint study led by the West Bengal University of Animal and Fishery Sciences to evaluate the ameliorative effect of turmeric and ginger powder against experimentally induced arsenic toxicity in calves, researchers showed that
* Turmeric and ginger powder significantly (P<0.05) reduced the plasma and hair arsenic levels through increased excretion via feces and urine.
* Turmeric and ginger treated groups inhibited the increased activity of AST and ALT of oxidative stress markers caused by arsenic toxicity.
* Blood profiles associated with toxicity also ameliorated by the administration of the combined formula.
* The Levels antioxidant enzymes produced by the host that was depressed by arsenic exposure were also increased by the treatment of turmeric and ginger treated groups.
Based on the results, researchers wrote, "The test drugs are found significantly effective not only to eliminate arsenic from the body but also give protection from possible damage caused by arsenic exposure".
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the prevention and treatment of diseases associated with chronic arsenic exposure, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Ameliorative effect of two Ayurvedic herbs on experimentally induced arsenictoxicity in calves by Biswas S1, Maji C1, Sarkar PK2, Sarkar S1, Chattopadhyay A3, Mandal TK. (PubMed)
(2) A Mechanistic Approach for Modulation of Arsenic Toxicity in Human Lymphocytes by Curcumin, an Active Constituent of Medicinal Herb Curcumalonga Linn by Mukherjee S1, Roy M, Dey S, Bhattacharya RK. (PubMed)
(3) Health Effects of Chronic Arsenic Exposure by Young-Seoub Hong,1,2 Ki-Hoon Song,3 and Jin-Yong Chun. (PMC)
Thursday, August 8, 2019
Green Tea and Green Tea Catechins In reduced Risk and Treatment of Pancreatic Cancer
Green tea may have a therapeutic and positive effect in reduced risk and treatment of pancreatic cancer, some scientists suggested.
Pancreatic cancer is a medical condition characterized by irregular cell growth in the tissues of the pancreas. At the later stage, the cancerous cell may travel a distance away to invade other healthy tissues and organs.
According to statistic, the average lifetime risk of pancreatic cancer for both men and women is about 1 in 65.
In the analysis of medical literature published online, green tea catechins, epigallocatechin gallate (EGCG) effect in reduced risk and treatment of pancreatic cancer was attributed to the contributions of various mechanisms.
In human pancreatic ductal adenocarcinoma (PDAC) cell lines PancTu-I, Panc1, Panc89 and BxPC3, to compare the inhibited effect of EGCG to 2 components of catechins, namely, catechin gallate (CG) and epicatechin gallate (ECG), application of green tea 2 catechins components demonstrated a strong effect in inhibited proliferation of PDAC cells in a dose- and time-dependent manner.
In a comparison test, green tea CG and ECG exerted much stronger anti-proliferation effects than those of EGCG.
The proliferation of PancTu-I cells retained by green tea catechin was attributed to the antioxidant effect in interference of the cancer cell division cycle through mediating the cytokines in modulation of cell cycle regulatory proteins, such as cyclins, a cell division regulators, cyclin-dependent kinase (Cdk) enzymes activated by cyclins in regulated cell progression through cell cycle arrest, and CDK inhibitors with function in prevented over-proliferation of cancer cells.
Additionally, all 3 components of green tea catechins also demonstrated a substantiated effect in the ameliorated secretion of pro-inflammatory and invasion promoting proteins of the cancer cell through the expression of TNF tumor necrosis factor in the activation of the nuclear factor NF-κB protein signaling involved mediation of DNA transcript, pro-inflammatory cytokines production, and cancer cell survival.
Tumor necrosis factor is a cell-signaling protein possessed a wide range of proinflammatory actions
NF-κB is a protein with function in the controlled transcription of DNA, cytokine production and cell survival.
Further analysis once again found that green tea catechins ECG and CG exhibit potent and much stronger anti-proliferate and anti-inflammatory activities on PDAC cells in compared to EGCG
In human pancreatic cancer cells lines MIA PaCa-2 cells, injection of green tea EGCG plus Bleomycin, (BLM), an anti-cancer chemotherapeutic drug displayed a substantial effect in inhibited cell proliferation through cell cycle transition phase arrest and mitochondrial depolarization by mitochondrial permeability transition in the induction of cell apoptosis, after 72 hours.
Additional examination, indicate that EGCG and BLM exhibited anti-proliferative effects significantly in induced apoptosis of MIA PaCa-2 cells and suggested that this combination could represent a new strategy with potential advantages for the treatment of pancreatic cancer.
In pancreatic cancer cell lines MIA PaCa-2 and PANC-1, injection of pterostilbene isolated from the blue berry and EGCG expressed a strongly additive antiproliferative effect after 72 hours with MIA underwent S-phase arrest but not in cancer cell line PANC-1.
Both pterostilbene and EGCG induced mitochondrial depolarization in enhanced cytochrome c released from mitochondria to trigger programmed cell death during the early stages of apoptosis was observed also in MIA, but not in PANC
EGCG increased caspase-3/7 function in induced cell apoptosis in MIA but the combined treatment did not significantly increase the activity in either cell lines. these contradictory activities may indicate that cell death occurs in MIA, possibly through another mechanism.
Taking all together, green tea with abundant antioxidant catechins may be used as an adjunct therapy for reduced risk and combined standard medicine for the treatment of pancreatic cancer.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Epicatechin gallate and catechin gallate are superior to epigallocatechin gallate in growth suppression and anti-inflammatory activities in pancreatic tumor cells. by Kürbitz C1, Heise D, Redmer T, Goumas F, Arlt A, Lemke J, Rimbach G, Kalthoff H, Trauzold A.(PubMed)
(2) Inhibitory effect of (-)-epigallocatechin-3-gallate and bleomycin on human pancreatic cancerMiaPaca-2 cell growth by Bimonte S#1, Leongito M#1, Barbieri A2, Del Vecchio V2, Barbieri M1, Albino V1, Piccirillo M1, Amore A1, Di Giacomo R1, Nasto A1, Granata V3, Petrillo A3, Arra C2, Izzo F1.(PubMed)
(3) Inhibitory effects of (-)-epigallocatechin-3-gallate and pterostilbene on pancreatic cancer growth in vitro by Kostin SF1, McDonald DE, McFadden DW.(PubMed)
Healthy Food Tomato Inhibits Hepatic Steatosis in Vivo
Hepatic steatosis is a medical condition caused by the accumulation of fat in the liver.
In other words, if the intrahepatic fat of your liver is more than 5% of liver weight, you are considered to have hepatic steatosis. Over time, untreated hepatic steatosis can lead to liver metabolic dysfunction, inflammation, and advanced forms of nonalcoholic fatty liver disease.
Epidemiologically, hepatic steatosis has been found to induce complications in patients with obesity, alcohol intoxication and/or hepatic disorders.
There are several mechanisms involved in the accumulation of intrahepatic fat, including increased flux of fatty acids to the liver, increased de novo lipogenesis, and/or reduced clearance through β-oxidation or very-low-density lipoprotein secretion.
People who are obese, having the condition of insulin resistance or diabetes, dyslipidemia, hypertension, metabolic syndrome, rapid weight loss, using hepatotoxic medications total parenteral nutrition (TPN) are at the increased risk of hepatic steatosis.
Out of many prevalent factors involved in the onset of hepatic steatosis, some researcher suggested that the promotion of the Western diet over the past few decades in the Western world may have a strong and negative impact that accelerates the incidence onset.
Dr. Michael D. Roberts, the lead scientist wrote, "Six weeks of WD feeding caused hepatic steatosis development as evidenced by the 2.25-fold increase in liver triacylglycerol content, but did not induce advanced liver disease (i.e., no overt inflammation or fibrosis)".
And, "sub-chronic WD feeding appears to increase hepatic steatosis development over a 6-week period but only induces select inflammation-related liver transcripts, mostly acute phase response genes. These findings continue to outline the early stages of NAFLD development prior to overt liver inflammation and advanced liver disease".
The results strongly suggested the risk of the Western diet on hepatic steatosis developing.
Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
In the urgency to discover healthy foods for the treatment of hepatic steatosis, researchers examined the effect of tomato consumption on biomarkers and gene expression related to lipid metabolism in rats with induced steatosis.
The study included 24 adult male Sprague-Dawley rats (8 weeks old) randomly assigned to (n = 6 rats/group) four experimental groups, including NA (normal diet and water), NL (normal diet and tomato juice), HA (high-fat diet and water) and HL (high-fat diet and tomato juice).
According to the tested assays, before treatment of tomato, HA group fed high-fat diet-induced hepatic steatosis confirmed by the levels of alanine aminotransferase and aspartate aminotransferase, an indication of liver stress and injury.
Tomato treated group showed a significant increase of levels of lycopene and its secondary metabolites in the livers of these animals, particularly in HL than in NL group, apparently due to higher absorption (63.07 vs. 44.45%).
Furthermore, tomato treated group protected the liver by alleviating oxidative stress through reduction of isoprostanes in the urine observed by increased levels of antioxidant enzymes.
Moreover, levels of high-density lipoprotein were also increased in the HL group compared to the HA group.
Interesting, overexpression of several genes related to lipid metabolism was also found in the HL group compared to nontreatment groups.
In other words, tomato inhibited the onset and progression of hepatic steatosis.in high-fat diet mice by inhibiting liver oxidative stress and enhancing lipid metabolism.
Dr. Martín-Pozuelo G, the lead scientist wrote, "The consumption of tomato juice and tomato products reduced hallmarks of steatosis, plasmatic triglycerides, and very-low-density lipoproteins, and increased lipid metabolism by inducing an overexpression of genes involved in more efficient fatty acid oxidation".
Taken altogether, tomato may be considered a dietary supplements for the prevention and treatment of hepatic steatosis, pending to large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The effect of tomato juice supplementation on biomarkers and gene expression related to lipid metabolism in rats with induced hepatic steatosis by Martín-Pozuelo G1, Navarro-González I, González-Barrio R, Santaella M, García-Alonso J, Hidalgo N, Gómez-Gallego C, Ros G, Periago MJ. (PubMed)
(2) Lipid biomarkers and metabolic effects of lycopene from tomato juice on liver of rats with induced hepatic steatosis by Bernal C1, Martín-Pozuelo G, Lozano AB, Sevilla A, García-Alonso J, Canovas M, Periago MJ. (PubMed)
(3) Western diet-induced hepatic steatosis and alterations in the liver transcriptome in adult Brown-Norway rats by Michael D. Roberts, C. Brooks Mobley, Ryan G. Toedebush, Alexander J. Heese, Conan Zhu,Anna E. Krieger, Clayton L. Cruthirds, Christopher M. Lockwood, John C. Hofheins,Charles E. Wiedmeyer, Heather J. Leidy, Frank W. Booth, and R. Scott Rector. (PMC)
In other words, if the intrahepatic fat of your liver is more than 5% of liver weight, you are considered to have hepatic steatosis. Over time, untreated hepatic steatosis can lead to liver metabolic dysfunction, inflammation, and advanced forms of nonalcoholic fatty liver disease.
Epidemiologically, hepatic steatosis has been found to induce complications in patients with obesity, alcohol intoxication and/or hepatic disorders.
There are several mechanisms involved in the accumulation of intrahepatic fat, including increased flux of fatty acids to the liver, increased de novo lipogenesis, and/or reduced clearance through β-oxidation or very-low-density lipoprotein secretion.
People who are obese, having the condition of insulin resistance or diabetes, dyslipidemia, hypertension, metabolic syndrome, rapid weight loss, using hepatotoxic medications total parenteral nutrition (TPN) are at the increased risk of hepatic steatosis.
Out of many prevalent factors involved in the onset of hepatic steatosis, some researcher suggested that the promotion of the Western diet over the past few decades in the Western world may have a strong and negative impact that accelerates the incidence onset.
Dr. Michael D. Roberts, the lead scientist wrote, "Six weeks of WD feeding caused hepatic steatosis development as evidenced by the 2.25-fold increase in liver triacylglycerol content, but did not induce advanced liver disease (i.e., no overt inflammation or fibrosis)".
And, "sub-chronic WD feeding appears to increase hepatic steatosis development over a 6-week period but only induces select inflammation-related liver transcripts, mostly acute phase response genes. These findings continue to outline the early stages of NAFLD development prior to overt liver inflammation and advanced liver disease".
The results strongly suggested the risk of the Western diet on hepatic steatosis developing.
Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
In the urgency to discover healthy foods for the treatment of hepatic steatosis, researchers examined the effect of tomato consumption on biomarkers and gene expression related to lipid metabolism in rats with induced steatosis.
The study included 24 adult male Sprague-Dawley rats (8 weeks old) randomly assigned to (n = 6 rats/group) four experimental groups, including NA (normal diet and water), NL (normal diet and tomato juice), HA (high-fat diet and water) and HL (high-fat diet and tomato juice).
According to the tested assays, before treatment of tomato, HA group fed high-fat diet-induced hepatic steatosis confirmed by the levels of alanine aminotransferase and aspartate aminotransferase, an indication of liver stress and injury.
Tomato treated group showed a significant increase of levels of lycopene and its secondary metabolites in the livers of these animals, particularly in HL than in NL group, apparently due to higher absorption (63.07 vs. 44.45%).
Furthermore, tomato treated group protected the liver by alleviating oxidative stress through reduction of isoprostanes in the urine observed by increased levels of antioxidant enzymes.
Moreover, levels of high-density lipoprotein were also increased in the HL group compared to the HA group.
Interesting, overexpression of several genes related to lipid metabolism was also found in the HL group compared to nontreatment groups.
In other words, tomato inhibited the onset and progression of hepatic steatosis.in high-fat diet mice by inhibiting liver oxidative stress and enhancing lipid metabolism.
Dr. Martín-Pozuelo G, the lead scientist wrote, "The consumption of tomato juice and tomato products reduced hallmarks of steatosis, plasmatic triglycerides, and very-low-density lipoproteins, and increased lipid metabolism by inducing an overexpression of genes involved in more efficient fatty acid oxidation".
Taken altogether, tomato may be considered a dietary supplements for the prevention and treatment of hepatic steatosis, pending to large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The effect of tomato juice supplementation on biomarkers and gene expression related to lipid metabolism in rats with induced hepatic steatosis by Martín-Pozuelo G1, Navarro-González I, González-Barrio R, Santaella M, García-Alonso J, Hidalgo N, Gómez-Gallego C, Ros G, Periago MJ. (PubMed)
(2) Lipid biomarkers and metabolic effects of lycopene from tomato juice on liver of rats with induced hepatic steatosis by Bernal C1, Martín-Pozuelo G, Lozano AB, Sevilla A, García-Alonso J, Canovas M, Periago MJ. (PubMed)
(3) Western diet-induced hepatic steatosis and alterations in the liver transcriptome in adult Brown-Norway rats by Michael D. Roberts, C. Brooks Mobley, Ryan G. Toedebush, Alexander J. Heese, Conan Zhu,Anna E. Krieger, Clayton L. Cruthirds, Christopher M. Lockwood, John C. Hofheins,Charles E. Wiedmeyer, Heather J. Leidy, Frank W. Booth, and R. Scott Rector. (PMC)
Wednesday, August 7, 2019
Healthy Food Onion, the Best Natural Anti-Hyperlipidemic Food
Hyperlipidemia or high blood cholesterol is a medical condition characterized by abnormally high levels of lipids in the blood.
Cholesterol produced by the liver plays an essential role in moderate amount in orchestrating the production of steroid hormone and vitamin D, building strong cell walls and aiding the digestive system in absorbing nutrients and fluids.
There are 2 types of blood cholesterol
* The high-density lipoprotein is also known as good cholesterol processes a function to return cholesterol to the liver.
* The low-density lipoprotein is also known as "bad" cholesterol processed a function aforementioned health benefits in moderate amount.
In a healthy individual, unused cholesterol is returned to the liver. However, overexpression of "bad" cholesterol due to the consumption of a high-fat diet and reduced levels of "good" cholesterol can cause bad cholesterol remaining in the bloodstream, leading to hyperlipidemia.
The healthy ratio of total blood cholesterol ("bad"/ "good") is any numbers that are less than 4.
Patients with yperlipidemia are assymptomatic. However, over time hyperlipidemia can cause plaque accumulated on the arterial wall, that causes atherosclerosis, a leading cause of heart disease and stroke.
According to the statistics provided by the CDC, in 2015–2016, more than 12% of adults age 20 and older had total cholesterol higher than 240 mg/dL, and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL in the US.
Believe it or not, hyperlipidemia, the life-long condition is treatable. By a change of diet and daily moderate exercise, you may control the condition without medication.
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
With an aim to find a potential and natural compound for the prevention and treatment hyperlipidemia, researchers examined the antihyperlipidemic and antioxidative potentials of onion (Allium cepa L.) extract fermented with a novel Lactobacillus casei HD-010.
Onion oral administration on ApoE-deficient mice, compared to bezafibrate (10 mg/kg, bw/day) as a positive control, showed a significant reduction of the levels of low-density lipoprotein (LDL), triglyceride (TG), and cholesterol.
Also, compared to the positive control, onion group displayed increased levels of high-density lipoprotein (HDL).
Furthermore, the levels of HMG-CoA reductase associated with the production of good cholesterol was increased by 20% in the fermented onion-treated group at 100 mg/kg.
Moreover, Cholesteryl Ester Transfer Protein (CETP) enzyme associated with moving cholesterol esters and triglycerides between VLDL, LDL, and HDL. LowerCETP levels promote HDL formation was inhibited by injection of onion compared to the control group.
Based on the findings, researchers said, "These results suggest that fermented onion has a preventive/therapeutic effect on the hyperlipidemic disease. It might have potential to be developed as a functional food".
In order to reveal more about the information about onion anti-hyperlipidemic activity, researchers evaluated the effects of raw red onion consumption on metabolic features in overweight and obese women with polycystic ovary syndrome.
The randomized controlled clinical trial, included a total of 54) patients randomly allocated to the intervention group as 'high-onion' (raw red onions: 2 × 40-50 g/day if overweight and 2 × 50-60 g/day if obese) or to the control group as 'low-onion' (raw red onions: 2 × 10-15 g/day) along with limited liliaceous vegetables for 8 weeks.
According to the tested analysis, onion administration significantly decreased the levels of total cholesterol in the high-onion group compared to the low-onion group.
Particularly, levels of low-density lipoprotein cholesterol decreased significantly in the high-onion group, compared to the low-onion group after treatment.
However, levels of triglycerides, high-density lipoprotein cholesterol and lipoprotein did not differ significantly after 8-week onion treatment.
These results strongly suggested that raw red onion consumption is effective in lower cholesterol in women with polycystic ovary syndrome.
Taken altogether, onion may be considered a remedy for the prevention and treatment of hyperlipidemia, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of raw red onion consumption on metabolic features in overweight or obese women with polycystic ovary syndrome: a randomized controlled clinical trial by Ebrahimi-Mamaghani M1, Saghafi-Asl M, Pirouzpanah S, Asghari-Jafarabadi M. (PubMed)
(2)Antihyperlipidemic and Antioxidative Potentials of Onion (Allium cepa L.) Extract Fermented with a Novel Lactobacillus casei HD-010 by Yang WS1,2, Kim JC3, Lee JY4, Kim CH5, Hwang CW6. (PubMed)
Cholesterol produced by the liver plays an essential role in moderate amount in orchestrating the production of steroid hormone and vitamin D, building strong cell walls and aiding the digestive system in absorbing nutrients and fluids.
There are 2 types of blood cholesterol
* The high-density lipoprotein is also known as good cholesterol processes a function to return cholesterol to the liver.
* The low-density lipoprotein is also known as "bad" cholesterol processed a function aforementioned health benefits in moderate amount.
In a healthy individual, unused cholesterol is returned to the liver. However, overexpression of "bad" cholesterol due to the consumption of a high-fat diet and reduced levels of "good" cholesterol can cause bad cholesterol remaining in the bloodstream, leading to hyperlipidemia.
The healthy ratio of total blood cholesterol ("bad"/ "good") is any numbers that are less than 4.
Patients with yperlipidemia are assymptomatic. However, over time hyperlipidemia can cause plaque accumulated on the arterial wall, that causes atherosclerosis, a leading cause of heart disease and stroke.
According to the statistics provided by the CDC, in 2015–2016, more than 12% of adults age 20 and older had total cholesterol higher than 240 mg/dL, and more than 18% had high-density lipoprotein (HDL, or “good”) cholesterol levels less than 40 mg/dL in the US.
Believe it or not, hyperlipidemia, the life-long condition is treatable. By a change of diet and daily moderate exercise, you may control the condition without medication.
The onion is a plant in the genus Allium, belonging to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
With an aim to find a potential and natural compound for the prevention and treatment hyperlipidemia, researchers examined the antihyperlipidemic and antioxidative potentials of onion (Allium cepa L.) extract fermented with a novel Lactobacillus casei HD-010.
Onion oral administration on ApoE-deficient mice, compared to bezafibrate (10 mg/kg, bw/day) as a positive control, showed a significant reduction of the levels of low-density lipoprotein (LDL), triglyceride (TG), and cholesterol.
Also, compared to the positive control, onion group displayed increased levels of high-density lipoprotein (HDL).
Furthermore, the levels of HMG-CoA reductase associated with the production of good cholesterol was increased by 20% in the fermented onion-treated group at 100 mg/kg.
Moreover, Cholesteryl Ester Transfer Protein (CETP) enzyme associated with moving cholesterol esters and triglycerides between VLDL, LDL, and HDL. LowerCETP levels promote HDL formation was inhibited by injection of onion compared to the control group.
Based on the findings, researchers said, "These results suggest that fermented onion has a preventive/therapeutic effect on the hyperlipidemic disease. It might have potential to be developed as a functional food".
In order to reveal more about the information about onion anti-hyperlipidemic activity, researchers evaluated the effects of raw red onion consumption on metabolic features in overweight and obese women with polycystic ovary syndrome.
The randomized controlled clinical trial, included a total of 54) patients randomly allocated to the intervention group as 'high-onion' (raw red onions: 2 × 40-50 g/day if overweight and 2 × 50-60 g/day if obese) or to the control group as 'low-onion' (raw red onions: 2 × 10-15 g/day) along with limited liliaceous vegetables for 8 weeks.
According to the tested analysis, onion administration significantly decreased the levels of total cholesterol in the high-onion group compared to the low-onion group.
Particularly, levels of low-density lipoprotein cholesterol decreased significantly in the high-onion group, compared to the low-onion group after treatment.
However, levels of triglycerides, high-density lipoprotein cholesterol and lipoprotein did not differ significantly after 8-week onion treatment.
These results strongly suggested that raw red onion consumption is effective in lower cholesterol in women with polycystic ovary syndrome.
Taken altogether, onion may be considered a remedy for the prevention and treatment of hyperlipidemia, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effects of raw red onion consumption on metabolic features in overweight or obese women with polycystic ovary syndrome: a randomized controlled clinical trial by Ebrahimi-Mamaghani M1, Saghafi-Asl M, Pirouzpanah S, Asghari-Jafarabadi M. (PubMed)
(2)Antihyperlipidemic and Antioxidative Potentials of Onion (Allium cepa L.) Extract Fermented with a Novel Lactobacillus casei HD-010 by Yang WS1,2, Kim JC3, Lee JY4, Kim CH5, Hwang CW6. (PubMed)
Green Tea EGCG, A Potent Iron Chelator in Regulation of Progression of Parkinson's disease
Green tea may be considered as a functional food and iron chelator in reduced risk and progression of Parkinson's disease, some scientists suggested
Iron chelation therapy is a primary and standard treatment for patients with iron overload.
Green tea is a precious drink processes numbers of health benefit known to almost everyone in Asia and the Western world.
Parkinson's disease (PD) is a progressive neurodegenerative disease, causing severe depletion of glutamatergic and dopaminergic inputs in the striatum.
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Investigation of the green tea EGCG effect in risk and progression of PD has been found to associate to many mechanisms involved numbers of aspects.
Application of metal chelation was found to ameliorate the expression of ROS in the induction of oxidative stress through a chain of reaction and precipitation of aggregation of alpha-synuclein and beta-amyloid peptides deposit in the brain, main leading causes to the onset of PD.
In iron abnormality PD subjects, oxidopamine, also known as 6-hydroxydopamine or 2,4,5-trihydroxyphenethylamine(6-OHD), a neurotoxic synthetic organic compound was found to disrupt iron metabolism, leading to overexpression of the iron induction of dyshomeostasis cause of iron toxicity and oxidative damage in dopaminergic neurons.
Green tea major polyphenol, (−)-epigallocatechin-3-gallate used in metal chelation, ameliorated iron-dependent free radicals located in the subcellular compartments and cellular membranes, through the effect in inhibited iron input and exhibited iron output in brain areas where it preferentially accumulates in neurodegenerative diseases, particularly Parkinsons' disease.
Further analysis of the neurotoxin 6-OHDA causes of iron unstable equilibrium, green extract GECG administration improved the function of hepcidin, a liver-derived hormone in regulated iron dyshomeostasis and gene expression of the iron metabolism through expressions of iron regulatory proteins (IRP1 and IRP2) in regulated the RNA level, between the transcription and the translation of the gene in expression of the iron homeostasis.
Indeed, In the differentiation of neurotoxin 6-OHDA induced iron dyshomeostasis has shown to increase oxidative stress in damage to neuron cells, green extract GECG effects demonstrated a significant inhibition of free radical and iron-free radical expression in the cellular membranes through the antioxidant activities and anti-inflammatory system and expression of nuclear factor-like 2(Nrf2) in stimulated production of antioxidant in protection against oxidative damage during injury and inflammation; heme oxygenase-1(HO-1) in increased production of superoxide dismutase and catalase against ROS and peroxisome proliferator-activated receptor-gamma (PPARγ) in regulated production of pro and anti-inflammatory cytokines and cytokines..
By reducing the overexpression of oxidative damage to neuron cells through regulation of iron-related factors as mentioned above, iron chelator EGCG can counteract these adverse effects and prevent the onset of PD.
Further study of the mechanism on disruption of iron metabolism by 6-OHDA in PD cell line N27, discovered that application of the iron chelator EGCG also disrupts the iron dyshomeostasis in N27 cells (dopaminergic neural cell line) induced by 6-OHDA through regulating iron transporters and regulators expression, such as DMT1 with function in mediation of the entry of dietary iron into these mucosal cells and TfR, a carrier protein for transferrin with function in import iron into the cell and regulated response to intracellular iron concentration and hepcidin, a central regulator in maintain iron homeostasis.
Dysregulation of hepcidin production results in a variety of iron disorders.
Additionally, in 6-OHDA induced neurotoxicity to cause PD, administration of green tea GECG also reduced the intracellular iron retention by decreasing the iron importers and increasing iron exporters, through regulation of the function of iron-regulated transporters, such as ferroportin.
Interestingly, there was a report suggested that the intervention of 3 cups of green tea daily for 3 months improved the antioxidant status and reduced oxidative damage in early PD patients without affecting their iron status.
The findings revealed that green tea bioactive polyphenol, (−)-epigallocatechin-3-gallate may be considered as an iron chelator in the regulation of PD progression.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources(1) Neuroprotective Properties of the Standardized Extract from Camellia sinensis (Green Tea) and Its Main Bioactive Components, Epicatechin and Epigallocatechin Gallate, in the 6-OHDA Model of Parkinson's Disease by Bitu Pinto N1, da Silva Alexandre B2, Neves KR3, Silva AH3, Leal LK3, Viana GS1.(PubMed)
(2) Green tea polyphenols prevent Parkinson's disease: in vitro and in vivo studies Dan Chen by Iowa State University
Tuesday, August 6, 2019
Green Tea, a Functional Food in Attenuated Risk and Treatment of Autoimmune Diseases
Green tea bioactive Epigallocatechin-3-gallate (EGCG) may have a therapeutic and profound effect in attenuated risk and treatment of autoimmune diseases, some scientists postulated.
Autoimmune diseases are class of diseases characterized by the immune system attacking its own tissues.
Green tea bioactive compound Epigallocatechin-3-gallate (EGCG) in the risk of autoimmune diseases was found to associate to many different mechanisms involved numbers of aspect.
In interleukin-1 receptor antagonist knockout (IL-1raKO) arthritis rodent models of human rheumatoid arthritis, intraperitoneal injection of EGCG three times per week after the first immunization showed a significant reduction of arthritis index observed by decreased damage and destruction of joint tissues.
The efficacy of green tea phytochemicals in inhibited arthritis expression was attributed to the activities in reduced production of pro-inflammatory cytokines in accumulation of inflammatory cells into the synovium for joint destruction and oxidative stress proteins in facilitated inflammation and destruction of the joints in arthritis.
Furthermore, the extract also exhibited anti STAT3 expression in a mediated variety of genes in response to cell stimuli to induce cellular processes such as cell growth and division, cell movement, and apoptosis activated by cytokine-dependent inflammation, through phosphorylation-Stat3 Antibody (y705) and (S727)in shortening the duration of STAT3 activity.
Interestingly, additional analysis also found that application of green tea bioactive compound lowers the mediation effect of mammalian target of rapamycin (mTOR) function in limited production of pro-inflammatory cytokines and hypoxia-inducible factor 1 (HIF-1) in the regulation of vascular endothelial growth factor (VEGF) function in the activated pro-inflammatory expression in innate immunity.
Moreover, injection of EGCG also exhibited anti-osteoclastic activity observed by reduced osteoclast markers in EGCG-treated IL-1RaKO mice.
In mice induced Sjögren's syndrome with pathogenic effects of reactive oxygen species (ROS) in the salivary glands, administration of green tea Epigallocatechin gallate (EGCG), was found to reduce overexpression of ROS in precipitated oxidative stress-induced DNA damage and apoptosis in MRL-Fas(lpr) mice with autoimmune sialadenitis through Heme oxygenase(HO)-1 in response to pro antioxidant expression and Bcl-2 with function to induce cell survival.
Additionally, in the investigation of the ameliorated effects of green tea in the risk of autoimmune sialadenitis in a murine model, application of the green tea extract chemical compound decreased the severity of sialadenitis substantially through reduced expressions of Thymine glycol (5,6-dihydroxy-5,6-dihydrothymine) with function in induced DNA damage by oxidation and ionizing radiation andgp91phox subunit of NADPH oxidase in the production of ROS to react to the acute phase of infection.
Further differentiation indicated that the chemical constituents also ameliorated single-stranded DNA (ssDNA) function in DNA duplication in both viruses and organisms and cleaved caspase 3 activity in the mediation of programmed cell death and TP53 or tumor protein in regulated apoptosis mediated by expression of BAX.
More profoundly, in the examine duct epithelial cells of salivary glands, EGCG-treated mice showed decreased levels of SS-A/Ro, an extractable nuclear antigen (ENA) and Sjögren syndrome antigen B or Lupus La protein (SSB/La) associated with autoimmune diseases such as systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS).
Finally, green tea EGCG-treated mice also showed a lower Ifi202b interferon activated gene 202B expression in implicated the development of systemic lupus erythematosus (SLE) and Ifi202 overexpression in the kidney and immune organs, an indication of significantly increased disease progression in autoimmune glomerulonephritis, according to publication of Gene ID: 26388, updated on 5-Nov-2017.
Taken together, green tea processed abundantly bioactive phytochemicals may be considered as a functional food in reduced risk and treatment of autoimmune diseases. Intake of green tea extract should be taken with care as overdose-toxicity has been reported in numbers of incidence.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(*) Epigallocatechin gallate inhibits oxidative stress-induced DNA damage and apoptosis in MRL-Fas(lpr) mice with autoimmune sialadenitis via upregulation of heme oxygenase-1 and Bcl-2. by Saito K1, Mori S, Date F, Ono M.(PubMed)
(*) EGCG attenuates autoimmune arthritis by inhibition of STAT3 and HIF-1α with Th17/Treg control by Yang EJ1, Lee J2, Lee SY1, Kim EK1, Moon YM1, Jung YO3, Park SH2, Cho ML1.(PubMed)
(*) Green tea EGCG, T cells, and T cell-mediated autoimmune diseases by Wu D1, Wang J, Pae M, Meydani SN.(PubMed)
(*) The ability of green tea to alleviate autoimmune diseases: fact or fiction? by Wu D, Wang J.
Autoimmune diseases are class of diseases characterized by the immune system attacking its own tissues.
Green tea bioactive compound Epigallocatechin-3-gallate (EGCG) in the risk of autoimmune diseases was found to associate to many different mechanisms involved numbers of aspect.
In interleukin-1 receptor antagonist knockout (IL-1raKO) arthritis rodent models of human rheumatoid arthritis, intraperitoneal injection of EGCG three times per week after the first immunization showed a significant reduction of arthritis index observed by decreased damage and destruction of joint tissues.
The efficacy of green tea phytochemicals in inhibited arthritis expression was attributed to the activities in reduced production of pro-inflammatory cytokines in accumulation of inflammatory cells into the synovium for joint destruction and oxidative stress proteins in facilitated inflammation and destruction of the joints in arthritis.
Furthermore, the extract also exhibited anti STAT3 expression in a mediated variety of genes in response to cell stimuli to induce cellular processes such as cell growth and division, cell movement, and apoptosis activated by cytokine-dependent inflammation, through phosphorylation-Stat3 Antibody (y705) and (S727)in shortening the duration of STAT3 activity.
Interestingly, additional analysis also found that application of green tea bioactive compound lowers the mediation effect of mammalian target of rapamycin (mTOR) function in limited production of pro-inflammatory cytokines and hypoxia-inducible factor 1 (HIF-1) in the regulation of vascular endothelial growth factor (VEGF) function in the activated pro-inflammatory expression in innate immunity.
Moreover, injection of EGCG also exhibited anti-osteoclastic activity observed by reduced osteoclast markers in EGCG-treated IL-1RaKO mice.
In mice induced Sjögren's syndrome with pathogenic effects of reactive oxygen species (ROS) in the salivary glands, administration of green tea Epigallocatechin gallate (EGCG), was found to reduce overexpression of ROS in precipitated oxidative stress-induced DNA damage and apoptosis in MRL-Fas(lpr) mice with autoimmune sialadenitis through Heme oxygenase(HO)-1 in response to pro antioxidant expression and Bcl-2 with function to induce cell survival.
Additionally, in the investigation of the ameliorated effects of green tea in the risk of autoimmune sialadenitis in a murine model, application of the green tea extract chemical compound decreased the severity of sialadenitis substantially through reduced expressions of Thymine glycol (5,6-dihydroxy-5,6-dihydrothymine) with function in induced DNA damage by oxidation and ionizing radiation andgp91phox subunit of NADPH oxidase in the production of ROS to react to the acute phase of infection.
Further differentiation indicated that the chemical constituents also ameliorated single-stranded DNA (ssDNA) function in DNA duplication in both viruses and organisms and cleaved caspase 3 activity in the mediation of programmed cell death and TP53 or tumor protein in regulated apoptosis mediated by expression of BAX.
More profoundly, in the examine duct epithelial cells of salivary glands, EGCG-treated mice showed decreased levels of SS-A/Ro, an extractable nuclear antigen (ENA) and Sjögren syndrome antigen B or Lupus La protein (SSB/La) associated with autoimmune diseases such as systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS).
Finally, green tea EGCG-treated mice also showed a lower Ifi202b interferon activated gene 202B expression in implicated the development of systemic lupus erythematosus (SLE) and Ifi202 overexpression in the kidney and immune organs, an indication of significantly increased disease progression in autoimmune glomerulonephritis, according to publication of Gene ID: 26388, updated on 5-Nov-2017.
Taken together, green tea processed abundantly bioactive phytochemicals may be considered as a functional food in reduced risk and treatment of autoimmune diseases. Intake of green tea extract should be taken with care as overdose-toxicity has been reported in numbers of incidence.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(*) Epigallocatechin gallate inhibits oxidative stress-induced DNA damage and apoptosis in MRL-Fas(lpr) mice with autoimmune sialadenitis via upregulation of heme oxygenase-1 and Bcl-2. by Saito K1, Mori S, Date F, Ono M.(PubMed)
(*) EGCG attenuates autoimmune arthritis by inhibition of STAT3 and HIF-1α with Th17/Treg control by Yang EJ1, Lee J2, Lee SY1, Kim EK1, Moon YM1, Jung YO3, Park SH2, Cho ML1.(PubMed)
(*) Green tea EGCG, T cells, and T cell-mediated autoimmune diseases by Wu D1, Wang J, Pae M, Meydani SN.(PubMed)
(*) The ability of green tea to alleviate autoimmune diseases: fact or fiction? by Wu D, Wang J.
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