Green Tea and Green Tea Catechins In reduced Risk and Treatment of Pancreatic Cancer

Green tea may have a therapeutic and positive effect in reduced risk and treatment of pancreatic cancer, some scientists suggested.

Pancreatic cancer is a medical condition characterized by irregular cell growth in the tissues of the pancreas. At the later stage, the cancerous cell may travel a distance away to invade other healthy tissues and organs.

According to statistic, the average lifetime risk of pancreatic cancer for both men and women is about 1 in 65.

In the analysis of medical literature published online, green tea catechins, epigallocatechin gallate (EGCG) effect in reduced risk and treatment of pancreatic cancer was attributed to the contributions of various mechanisms.


In human pancreatic ductal adenocarcinoma (PDAC) cell lines PancTu-I, Panc1, Panc89 and BxPC3, to compare the inhibited effect of EGCG to 2 components of catechins, namely, catechin gallate (CG) and epicatechin gallate (ECG), application of green tea 2 catechins components demonstrated a strong effect in inhibited proliferation of PDAC cells in a dose- and time-dependent manner.
In a comparison test, green tea CG and ECG exerted much stronger anti-proliferation effects than those of EGCG.

The proliferation of PancTu-I cells retained by green tea catechin was attributed to the antioxidant effect in interference of the cancer cell division cycle through mediating the cytokines in modulation of cell cycle regulatory proteins, such as cyclins, a cell division regulators, cyclin-dependent kinase (Cdk) enzymes activated by cyclins in regulated cell progression through cell cycle arrest, and CDK inhibitors with function in prevented over-proliferation of cancer cells.
Additionally, all 3 components of green tea catechins also demonstrated a substantiated effect in the ameliorated secretion of pro-inflammatory and invasion promoting proteins of the cancer cell through the expression of TNF tumor necrosis factor in the activation of the nuclear factor NF-κB protein signaling involved mediation of DNA transcript, pro-inflammatory cytokines production, and cancer cell survival.

Tumor necrosis factor is a cell-signaling protein possessed a wide range of proinflammatory actions

NF-κB is a protein with function in the controlled transcription of DNA, cytokine production and cell survival.


Further analysis once again found that green tea catechins ECG and CG exhibit potent and much stronger anti-proliferate and anti-inflammatory activities on PDAC cells in compared to EGCG


In human pancreatic cancer cells lines MIA PaCa-2 cells, injection of green tea EGCG plus Bleomycin, (BLM), an anti-cancer chemotherapeutic drug displayed a substantial effect in inhibited cell proliferation through cell cycle transition phase arrest and mitochondrial depolarization by mitochondrial permeability transition in the induction of cell apoptosis, after 72 hours.

Additional examination, indicate that EGCG and BLM exhibited anti-proliferative effects significantly in induced apoptosis of MIA PaCa-2 cells and suggested that this combination could represent a new strategy with potential advantages for the treatment of pancreatic cancer.
In pancreatic cancer cell lines MIA PaCa-2 and PANC-1, injection of pterostilbene isolated from the blue berry and EGCG expressed a strongly additive antiproliferative effect after 72 hours with MIA underwent S-phase arrest but not in cancer cell line PANC-1.

Both pterostilbene and EGCG induced mitochondrial depolarization in enhanced cytochrome c released from mitochondria to trigger programmed cell death during the early stages of apoptosis was observed also in MIA, but not in PANC

EGCG increased caspase-3/7 function in induced cell apoptosis in MIA but the combined treatment did not significantly increase the activity in either cell lines. these contradictory activities may indicate that cell death occurs in MIA, possibly through another mechanism.

Taking all together, green tea with abundant antioxidant catechins may be used as an adjunct therapy for reduced risk and combined standard medicine for the treatment of pancreatic cancer.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Epicatechin gallate and catechin gallate are superior to epigallocatechin gallate in growth suppression and anti-inflammatory activities in pancreatic tumor cells. by Kürbitz C1, Heise D, Redmer T, Goumas F, Arlt A, Lemke J, Rimbach G, Kalthoff H, Trauzold A.(PubMed)
(2) Inhibitory effect of (-)-epigallocatechin-3-gallate and bleomycin on human pancreatic cancerMiaPaca-2 cell growth by Bimonte S#1, Leongito M#1, Barbieri A2, Del Vecchio V2, Barbieri M1, Albino V1, Piccirillo M1, Amore A1, Di Giacomo R1, Nasto A1, Granata V3, Petrillo A3, Arra C2, Izzo F1.(PubMed)
(3) Inhibitory effects of (-)-epigallocatechin-3-gallate and pterostilbene on pancreatic cancer growth in vitro by Kostin SF1, McDonald DE, McFadden DW.(PubMed)