Myalgia is a group of diseases associated with muscle pain.
Most common types of myalgia are
* Systemic lupus erythematosus
The systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the body's immune system abnormal function that attacks healthy tissue in many parts of the body, inducing symptoms of severe fatigue, joint pain, swelling, and headaches.
*Systemic sclerosis
Systemic sclerosis (SSc) is an autoimmune disease of the connective tissue that may be misdiagnosed as rheumatoid arthritis. According to Dr. Horimoto AM and Dr. Costa IP, arthritis, clinically observed, maybe a feature often found in a patient with Systemic sclerosis, often leading to early misdiagnosis with rheumatoid arthritis (RA).
The most common symptoms of systemic sclerosis are hair loss, calcium deposits, or white lumps under the skin, small, dilated blood vessels under the skin's surface and joint pain.
* Polymyositis
Polymyositis (PM) is a type of chronic inflammation of the muscles associated with dermatomyositis and inclusion body myositis.
The most common system of polymyositis is muscle pain and stiffness, muscle weakness, particularly in the belly (abdomen), shoulders, upper arms, and hips and joint pain and stiffness.
The most common causes of myalgia are overuse, injury, or strain of muscles. However, myalgia can also be caused by diseases, medications, and in some, it is a response to vaccination.
Conventionally, most cases of myalgia are treated by over-the-counter medications such as Tylenol (acetaminophen) or nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen, and naproxen
Comfrey is a perennial plant in the genus of Symphytum, belonging to the family Boraginaceae, native to Europe. It has been used in herbal and traditional medicine to ease excessive bleeding or on open wounds, relieve pain and swollen, treat circulation issues, reduce cholesterol, etc.
On finding a potential compound for the treatment of diseases associated with chronic pain, researchers investigated the effectiveness and tolerability of the topical Symphytum product Traumaplant (Harras Pharma Curarina, München, Germany) (10% active ingredient of a 2.5:1 aqueous-ethanolic pressed concentrate of freshly harvested, cultivated comfrey herb [Symphytum uplandicum Nyman], corresponding to 25 g of fresh herb per 100 g of cream) in the treatment of patients with myalgia (n=104) were tested against a 1% reference product (corresponding to 2.5 g of fresh comfrey herb in 100 g of cream; n=111).
According to the results from the primary efficacy parameter in this double-blind, reference- controlled, randomized, multicenter study of 215 patients with pain in the lower and upper back and motion and the. secondary efficacy parameters included pain at rest, pain on palpation, and functional impairment, high concentrations of the treatment product showed a significant amelioration of pain on active motion (P<5 x 10 -9 ), pain at rest (P<.001), and pain on palpation compared to the reference product which was clinically highly relevant.
The high-concentration product exerted a significantly better global efficacy and faster onset of effects.
Tolerability of the highly concentrated study product was good to excellent in all patients.
Based on the results, researchers said, "Study results confirm the known anti-inflammatory and analgesic effects of topical (Symphytum cream. As a new finding, applicability in certain forms of back pain can be concluded".
Taken altogether, Comfrey combined with other herbal medicine for the treatment of myalgia, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Topical symphytum herb concentrate cream against myalgia: a randomized controlled double-blind clinical study by Kucera M1, Barna M, Horàcek O, Kàlal J, Kucera A, Hladìkova M. (PubMed)
Monday, March 16, 2020
Sunday, March 15, 2020
Herbal Ashwagandha inhibits the Pre-Cancer Stage of Multiple Myeloma in Vitro
Cancer is a group of diseases characterized by the irregular cell growth on the body tissue, due to the alternation of cell DNA.
Most cases of cancer start in the cell on the surface of the inner lining tissue and do not exert any symptoms at the early stage.
At the later stage, the larger size tumor may press on the nearby blood vessels and nerve cells, causing localized severe bleeding and pain accompanied by the general symptoms of cancers, including the unintended weight loss, loss of appetite, fatigue and tiredness and gastrointestinal problems.
Most cancer cells at this stage can also travel a distance away from the original site to affect other healthy tissue and organs, leading to secondary metastasis.
Pre-cancer is a medical condition that likely develops into cancer if untreated.
Monoclonal gammopathy of undetermined significance (MGUS) is a precancerous condition and the most common plasma cell disorder.
In other words, monoclonal myeloma gammopathies is a precancerous condition that may cause myeloma, a cancer of white blood cell disorder.
Multiple myelomas. also known as plasma cell myeloma or Kahler's disease, is a type of abnormal growth of plasma cells collected in the none marrow where they grow and multiply to interfere with the production of normal blood cells.
According to the study by the Harvard Medical School, paraprotein, an abnormal antibody produced by the plasma cell myeloma not only can cause kidney problem but also interference with the Roche automated total bilirubin, including total bilirubin (TBIL), direct bilirubin (DBIL), or HDL-cholesterol (HDL-C).
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound that processes the anti-cancer property, researchers examined the effects of Withaferin A (WA) isolated from the plant Withania somnifera, antitumor effects on a multiple myeloma cell model.
According to the results from Ingenuity Pathway Analysis and Western blot, WA exerted a significant action against monoclonal gammopathy of undetermined significance (MGUS) and related disorders.
Furthermore, WA showed a strong and massive blockage on both proteotoxic and oxidative stress response pathways by targeting protein networks such as multicatalytic proteinase complex, associated with the risk of monoclonal gammopathy.
In other words, WA mediated apoptosis is preceded by simultaneous targeting of cellular stress response pathways like proteasome degradation, autophagy and unfolded protein stress response.
Based on the findings, researchers said, "the combined approach can be used for other types of cancer and/or other promising multifunctional compounds, thereby increasing the potential development of new antitumor therapies".
Taken altogether, Ashwagandhaprocessed abundantly WA may be considered a functional herb for the modulation of the monoclonal myeloma gammopathies, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Proteomic characterization of Withaferin A-targeted protein networks for the treatment of monoclonal myeloma gammopathies by Dom M1, Offner F2, Vanden Berghe W1, Van Ostade X. (PubMed)
(2) Multiple Myeloma by Kyle J. Norton
Most cases of cancer start in the cell on the surface of the inner lining tissue and do not exert any symptoms at the early stage.
At the later stage, the larger size tumor may press on the nearby blood vessels and nerve cells, causing localized severe bleeding and pain accompanied by the general symptoms of cancers, including the unintended weight loss, loss of appetite, fatigue and tiredness and gastrointestinal problems.
Most cancer cells at this stage can also travel a distance away from the original site to affect other healthy tissue and organs, leading to secondary metastasis.
Pre-cancer is a medical condition that likely develops into cancer if untreated.
Monoclonal gammopathy of undetermined significance (MGUS) is a precancerous condition and the most common plasma cell disorder.
In other words, monoclonal myeloma gammopathies is a precancerous condition that may cause myeloma, a cancer of white blood cell disorder.
Multiple myelomas. also known as plasma cell myeloma or Kahler's disease, is a type of abnormal growth of plasma cells collected in the none marrow where they grow and multiply to interfere with the production of normal blood cells.
According to the study by the Harvard Medical School, paraprotein, an abnormal antibody produced by the plasma cell myeloma not only can cause kidney problem but also interference with the Roche automated total bilirubin, including total bilirubin (TBIL), direct bilirubin (DBIL), or HDL-cholesterol (HDL-C).
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound that processes the anti-cancer property, researchers examined the effects of Withaferin A (WA) isolated from the plant Withania somnifera, antitumor effects on a multiple myeloma cell model.
According to the results from Ingenuity Pathway Analysis and Western blot, WA exerted a significant action against monoclonal gammopathy of undetermined significance (MGUS) and related disorders.
Furthermore, WA showed a strong and massive blockage on both proteotoxic and oxidative stress response pathways by targeting protein networks such as multicatalytic proteinase complex, associated with the risk of monoclonal gammopathy.
In other words, WA mediated apoptosis is preceded by simultaneous targeting of cellular stress response pathways like proteasome degradation, autophagy and unfolded protein stress response.
Based on the findings, researchers said, "the combined approach can be used for other types of cancer and/or other promising multifunctional compounds, thereby increasing the potential development of new antitumor therapies".
Taken altogether, Ashwagandhaprocessed abundantly WA may be considered a functional herb for the modulation of the monoclonal myeloma gammopathies, pending to the result of larger sample size and multicenter study
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Proteomic characterization of Withaferin A-targeted protein networks for the treatment of monoclonal myeloma gammopathies by Dom M1, Offner F2, Vanden Berghe W1, Van Ostade X. (PubMed)
(2) Multiple Myeloma by Kyle J. Norton
Herbal Comfrey(Symphytum officinale L.) Speeds Up Wound Healing
Wound healing is the natural process by covering up the damage and injury of the body,
Skin wound healing is a process to repair skin damage and injury.
The process involves 4 phases
* The first phase of wound healing is cover up the wound. In this phase, the immune first line of defense white blood cells stimulates the emergency repair system in the production of blood clotting to block the drainage.
* In phase 2, the white blood cells activates the proteins associated with the inflammatory cytokines to destroy the pathogens before they can enter the body through the wound.
In most cases, due to the overproduction of proinflammatory cytokines, patients may experience symptoms of fever, and localized pain, redness, and swelling.
Furthermore, the production of pro-inflammatory cytokines in some case can cause the death of nearby healthy cells, leading to the formation of irreversible scars, as seen in the liver.
* In phase 3, new blood vessels and tissues are formed in the damage and injury area.
* The recovery phase.
The final phase of the wound healing is involved in the remodeling of collagen from type III to type I cellular activity reduces.
However, the healing process is easier said than done, the complex process in many cases is interrupted by local and systemic factors, including moisture, infection, age, and nutritional status, leading to abnormal cell membrane repair, a major cause of skin scars.
Comfrey is a perennial plant in the genus of Symphytum, belonging to the family Boraginaceae, native to Europe. It has been used in herbal and traditional medicine to ease excessive bleeding or on open wounds, relieve pain and swollen, treat circulation issues, reduce cholesterol, etc.
On finding a potential compound to speed up injury recovery, researchers investigated the wound healing effects of a topically applied preparation (Traumaplant) containing a concentrate (10 % active ingredient) from the aerial parts of medicinal comfrey (Symphytum x uplandicum NYMAN).
A randomized clinical double-blind study including 278 patients with fresh abrasions (verum n = 137), among them, 64 patients of up to 20 years of age (verum n = 29, reference product n = 35)with an otherwise identical low-dose preparation (1 % active ingredient; n = 141) used as a control.
According to the results of the examination, after 2-3 days of applied medication exerted a highly significantly and clinically relevantly faster initial reduction of wound size of 49 + or - 19 % versus 29 + or - 13 % per day in favor of verum (p < 5x10(-21))compared to control.
Furthermore, the linear regression time to complete healing was 2.97 days faster with verum compared to control reference.
The physicians rated efficacy as good to very good in 93.4 % of cases, as compared to only 61.7 % in the control.
Moreover, on a scale of 0-100 verum was rated with 84.4 + or - 10.1 points by the patients themselves, compared to the rate of 65.5 in the control.
No adverse effects or problems with drug tolerability occurred. Specifically, the cutaneous reactions throughout the 10-day observation phase.
Based on the findings, researchers said, "Symphytum herb extract can be attributed to distinct wound healing effects, effects that can explicitly be used in paediatry.".
Taken altogether, Comfrey may be considered a remedy for speeding up wound healing, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [Wound healing effects of a Symphytum herb extract cream (Symphytum x uplandicum NYMAN: ): results of a randomized, controlled double-blind study].[Article in German] byBarna M1, Kucera A, Hladícova M, Kucera M. (PubMed)
Skin wound healing is a process to repair skin damage and injury.
The process involves 4 phases
* The first phase of wound healing is cover up the wound. In this phase, the immune first line of defense white blood cells stimulates the emergency repair system in the production of blood clotting to block the drainage.
* In phase 2, the white blood cells activates the proteins associated with the inflammatory cytokines to destroy the pathogens before they can enter the body through the wound.
In most cases, due to the overproduction of proinflammatory cytokines, patients may experience symptoms of fever, and localized pain, redness, and swelling.
Furthermore, the production of pro-inflammatory cytokines in some case can cause the death of nearby healthy cells, leading to the formation of irreversible scars, as seen in the liver.
* In phase 3, new blood vessels and tissues are formed in the damage and injury area.
* The recovery phase.
The final phase of the wound healing is involved in the remodeling of collagen from type III to type I cellular activity reduces.
However, the healing process is easier said than done, the complex process in many cases is interrupted by local and systemic factors, including moisture, infection, age, and nutritional status, leading to abnormal cell membrane repair, a major cause of skin scars.
Comfrey is a perennial plant in the genus of Symphytum, belonging to the family Boraginaceae, native to Europe. It has been used in herbal and traditional medicine to ease excessive bleeding or on open wounds, relieve pain and swollen, treat circulation issues, reduce cholesterol, etc.
On finding a potential compound to speed up injury recovery, researchers investigated the wound healing effects of a topically applied preparation (Traumaplant) containing a concentrate (10 % active ingredient) from the aerial parts of medicinal comfrey (Symphytum x uplandicum NYMAN).
A randomized clinical double-blind study including 278 patients with fresh abrasions (verum n = 137), among them, 64 patients of up to 20 years of age (verum n = 29, reference product n = 35)with an otherwise identical low-dose preparation (1 % active ingredient; n = 141) used as a control.
According to the results of the examination, after 2-3 days of applied medication exerted a highly significantly and clinically relevantly faster initial reduction of wound size of 49 + or - 19 % versus 29 + or - 13 % per day in favor of verum (p < 5x10(-21))compared to control.
Furthermore, the linear regression time to complete healing was 2.97 days faster with verum compared to control reference.
The physicians rated efficacy as good to very good in 93.4 % of cases, as compared to only 61.7 % in the control.
Moreover, on a scale of 0-100 verum was rated with 84.4 + or - 10.1 points by the patients themselves, compared to the rate of 65.5 in the control.
No adverse effects or problems with drug tolerability occurred. Specifically, the cutaneous reactions throughout the 10-day observation phase.
Based on the findings, researchers said, "Symphytum herb extract can be attributed to distinct wound healing effects, effects that can explicitly be used in paediatry.".
Taken altogether, Comfrey may be considered a remedy for speeding up wound healing, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [Wound healing effects of a Symphytum herb extract cream (Symphytum x uplandicum NYMAN: ): results of a randomized, controlled double-blind study].[Article in German] byBarna M1, Kucera A, Hladícova M, Kucera M. (PubMed)
Saturday, March 14, 2020
The Herbal Medicines that Treat Unspecific Low Back Pain
Low back pain is a musculoskeletal disorder (MSDs) of degenerative disc disease, with pain persisted for longer than 3 months, affecting over 80% of the population in the US alone some points in their life.
Chronic LBP prevalence in older adults was significantly higher than the 21-to-44-year age group and inflicted more disabled, longer symptom duration, etc.(2). The unique impact of CLBP is unknown(3).
Acute lower back pain is a common musculoskeletal disorder (MSDs) caused by injury to the muscles, ligaments, joints, or discs that last less than a few months.
Chronic lower back pain that lasts longer than 6 months, normally caused by damage of nerves in the low back which supplies sensation and power the muscles in the pelvis, legs, and feet.
According to the statistics, up to 80% of the population will experience back pain at some time in their lives. The condition affects people of all ages, particularly in occupations required the use of muscles of the lower back often.
Worldwide, years lived with a disability caused by low back pain have increased by 54% between 1990 and 2015.
Depending on the severity of the condition, chronic lower back pain can induce symptoms of numbness, tingling, or weakness in one or both legs and intense, constant pain that gets worse at night.
Some people with chronic lower back pain may also experience symptoms of loss of bowel or bladder control and unexplained weight loss.
According to the statistics, the lifetime prevalence of non-specific (common) low back pain is estimated at 60% to 70% in industrialized countries with a one-year prevalent rate ranging from 15% to 45%. The adult incidence of lower back pain is 5% per year.
Comfrey is a perennial plant in the genus of Symphytum, belonging to the family Boraginaceae, native to Europe. It has been used in herbal and traditional medicine to ease excessive bleeding or on open wounds, relieve pain and swollen, treat circulation issues, reduce cholesterol, etc.
On finding a potential compound for the treatment of diseases associated with neuro and muscle pain, researchers examined the effectiveness of herbal medicine, including comfrey for nonspecific low back pain (LBP).
A systematic review of randomized controlled trials (RCTs) involved in the searching of studies published on numerous electronic databases up to September 2014 found 14 RCTs with 2050 participants/
Capsicum frutescens (cayenne) reduces pain more than placebo.
Although Harpagophytum procumbens (devil's claw), Salix alba (white willow bark), Symphytum officinale L. (comfrey), Solidago chilensis (Brazilian arnica), and Lavender essential oil also seem to reduce pain more than placebo, evidence for these substances was of moderate quality at best.
All tested herbal medicine herbal showed no significant adverse events within the included trials.
Taken altogether, Comfrey and other herbal medicine may be considered a remedy for the treatment of unspecific low back pain, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Herbal Medicine for Low Back Pain: A Cochrane Review by Gagnier JJ1, Oltean H, van Tulder MW, Berman BM, Bombardier C, Robbins CB. (PubMed)
(2) Herbal medicine for low-back pain by Oltean H1, Robbins C, van Tulder MW, Berman BM, Bombardier C, Gagnier JJ. (PubMed)
Chronic LBP prevalence in older adults was significantly higher than the 21-to-44-year age group and inflicted more disabled, longer symptom duration, etc.(2). The unique impact of CLBP is unknown(3).
Acute lower back pain is a common musculoskeletal disorder (MSDs) caused by injury to the muscles, ligaments, joints, or discs that last less than a few months.
Chronic lower back pain that lasts longer than 6 months, normally caused by damage of nerves in the low back which supplies sensation and power the muscles in the pelvis, legs, and feet.
According to the statistics, up to 80% of the population will experience back pain at some time in their lives. The condition affects people of all ages, particularly in occupations required the use of muscles of the lower back often.
Worldwide, years lived with a disability caused by low back pain have increased by 54% between 1990 and 2015.
Depending on the severity of the condition, chronic lower back pain can induce symptoms of numbness, tingling, or weakness in one or both legs and intense, constant pain that gets worse at night.
Some people with chronic lower back pain may also experience symptoms of loss of bowel or bladder control and unexplained weight loss.
According to the statistics, the lifetime prevalence of non-specific (common) low back pain is estimated at 60% to 70% in industrialized countries with a one-year prevalent rate ranging from 15% to 45%. The adult incidence of lower back pain is 5% per year.
Comfrey is a perennial plant in the genus of Symphytum, belonging to the family Boraginaceae, native to Europe. It has been used in herbal and traditional medicine to ease excessive bleeding or on open wounds, relieve pain and swollen, treat circulation issues, reduce cholesterol, etc.
On finding a potential compound for the treatment of diseases associated with neuro and muscle pain, researchers examined the effectiveness of herbal medicine, including comfrey for nonspecific low back pain (LBP).
A systematic review of randomized controlled trials (RCTs) involved in the searching of studies published on numerous electronic databases up to September 2014 found 14 RCTs with 2050 participants/
Capsicum frutescens (cayenne) reduces pain more than placebo.
Although Harpagophytum procumbens (devil's claw), Salix alba (white willow bark), Symphytum officinale L. (comfrey), Solidago chilensis (Brazilian arnica), and Lavender essential oil also seem to reduce pain more than placebo, evidence for these substances was of moderate quality at best.
All tested herbal medicine herbal showed no significant adverse events within the included trials.
Taken altogether, Comfrey and other herbal medicine may be considered a remedy for the treatment of unspecific low back pain, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Herbal Medicine for Low Back Pain: A Cochrane Review by Gagnier JJ1, Oltean H, van Tulder MW, Berman BM, Bombardier C, Robbins CB. (PubMed)
(2) Herbal medicine for low-back pain by Oltean H1, Robbins C, van Tulder MW, Berman BM, Bombardier C, Gagnier JJ. (PubMed)
Cramp Bark (Viburnum opulus) Exerts Cytoprotective Effects Against Colorectal Cancer in Vitro
Cancer is a group of medical and chronic diseases characterized by cell growth disorderly and uncontrollably in the tissue of specific organs in the body.
Over time, the alternative cells induced tumor may become progressively worse and damage other healthy tissues, depending on the grade of the tumor.
At the later stage, the most invasive tumor can induce secondary metastasis by spreading to other organs in the body via lymph or blood.
According to the National Cancer Institute, approximately 38.4% of men and women will be diagnosed with cancer at some points during their lifetimes, according to the data from 2013–2015.
In 2017, an estimated 15,270 children and adolescents ages 0 to 19 were diagnosed with cancer and 1,790 died of the disease.
The cancer cytotoxicity is an activity to cause the destruction of cancer cells by causing cancer cell apoptosis
Cytotoxic activity is a process to induce toxic to cells.
Cramp Bark is an ornamental plant, genus Viburnum, belonging to the family Adoxaceae, native to Europe and Asia. It has been used in traditional and herbal medicine as anti-spasmodic, anti-inflammatory, nervine. hypotensive agent and to treat menstrual cramps and pain, afterbirth, postpartum pains, excessive blood loss in periods, bleeding associated with the menopause, etc.
On finding a potential herbal medicine for the prevention and treatment of cancer, researchers examined the effects of Cramp Bark(Viburnum opulus) extract cytoprotective activity on Caco-2 cell, the continuous line of heterogeneous human epithelial colorectal adenocarcinoma cells.
According to the tested analysis, the extract showed a strong anti-tumor property in modulating the cellular membrane dynamic in the progression of the cancer cells.
Furthermore, the application exerted a strong chemo-preventive activity against oxidative stress-induced chemically by tert-butyl hydroperoxide (t-BOOH).
Moreover, the antioxidants activity of the extract also inhibits DNA damage by initiating the DNA self-repair after cell exposition to reactive oxygen species, methylnitronitrosoguanidine (MNNG) and H2O2.
Taken altogether, cramp bark(Viburnum opulus) may be considered a functional herb which processes cytoprotective activity, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Viburnum opulus Fruit Phenolic Compounds as Cytoprotective Agents Able to Decrease Free Fatty Acids and Glucose Uptake by Caco-2 Cells by Zakłos-Szyda M1, Pawlik N2, Polka D2, Nowak A3, Koziołkiewicz M2, Podsędek A. (PubMed)
Over time, the alternative cells induced tumor may become progressively worse and damage other healthy tissues, depending on the grade of the tumor.
At the later stage, the most invasive tumor can induce secondary metastasis by spreading to other organs in the body via lymph or blood.
According to the National Cancer Institute, approximately 38.4% of men and women will be diagnosed with cancer at some points during their lifetimes, according to the data from 2013–2015.
In 2017, an estimated 15,270 children and adolescents ages 0 to 19 were diagnosed with cancer and 1,790 died of the disease.
The cancer cytotoxicity is an activity to cause the destruction of cancer cells by causing cancer cell apoptosis
Cytotoxic activity is a process to induce toxic to cells.
Cramp Bark is an ornamental plant, genus Viburnum, belonging to the family Adoxaceae, native to Europe and Asia. It has been used in traditional and herbal medicine as anti-spasmodic, anti-inflammatory, nervine. hypotensive agent and to treat menstrual cramps and pain, afterbirth, postpartum pains, excessive blood loss in periods, bleeding associated with the menopause, etc.
On finding a potential herbal medicine for the prevention and treatment of cancer, researchers examined the effects of Cramp Bark(Viburnum opulus) extract cytoprotective activity on Caco-2 cell, the continuous line of heterogeneous human epithelial colorectal adenocarcinoma cells.
According to the tested analysis, the extract showed a strong anti-tumor property in modulating the cellular membrane dynamic in the progression of the cancer cells.
Furthermore, the application exerted a strong chemo-preventive activity against oxidative stress-induced chemically by tert-butyl hydroperoxide (t-BOOH).
Moreover, the antioxidants activity of the extract also inhibits DNA damage by initiating the DNA self-repair after cell exposition to reactive oxygen species, methylnitronitrosoguanidine (MNNG) and H2O2.
Taken altogether, cramp bark(Viburnum opulus) may be considered a functional herb which processes cytoprotective activity, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Viburnum opulus Fruit Phenolic Compounds as Cytoprotective Agents Able to Decrease Free Fatty Acids and Glucose Uptake by Caco-2 Cells by Zakłos-Szyda M1, Pawlik N2, Polka D2, Nowak A3, Koziołkiewicz M2, Podsędek A. (PubMed)
Friday, March 13, 2020
Herbal Cleaver(Galium aparine), the Best Remedy for the Treatment of Hypertension
Blood pressure is the force of the blood pushing against the arterial walls. In high blood pressure, the heart has to work harder than normal to pump blood through the circulation system. Over time, high blood pressure has been found to cause damage to the heart and arteries.
Hypertension or high blood pressure is a condition characterized by persistent high blood pressure.
In the US approximately, one-third of the adults have high blood pressure, affecting over 77 million people in the country.
Additionally, among adults age 20 and older in the United States, in the non-Hispanic whites community, 33.4 percent of men and 30.7 percent of women are infected by the syndrome.
High blood pressure is a slowly developed condition. Unless the syndrome has caused damage to the blood vessel, otherwise symptoms cannot be detected.
The cause of high blood pressure is a result of hardening and thickening of the arteries (atherosclerosis), due to the slow progression of plaques accumulated on the wall of the arteries.
High blood pressure can be acute or chronic. Acute high blood pressure most often occurs to people with sudden stress.
Acute high blood pressure can be caused by intense physical exercise. As the heart must pump harder to provide the needs of nutrients and oxygen.
Most cases of chronic high blood pressure are associated with an unhealthy lifestyle and chronic diseases such as kidney disease, leading to the onset of strokes and cardiovascular disease.
Abnormal high blood pressure, depending on how high of the numbers, patients may experience symptoms of a headache to a severe headache., fatigue, vision problems. However, in severe cases, high blood pressure can also induce chest pain, difficulty breathing, irregular heartbeat and confusion.
Untreated high blood pressure epidemiologically can cause complications of retinopathy, lead to damage to the retina or bleeding in the eye, blurred vision and complete loss of vision.
Cleaver is a herbaceous annual plant, genus Galium, belonging to the family Rubiaceae, native to North America and Eurasia. The herb has been used over thousands of years in herbal and traditional medicine as mild diuretic and blood and lymphatic cleanser and to treat psoriasis, skin conditions, glands, tonsillitis, bladder infections, prevent small kidney stone, etc.
On finding a potential compound for the prevention and treatment of cardiovascular diseases (CVD), researchers investigated the antihypertensive and antioxidant potential of vanillic acid (VA) found in cleaver, in N(ω)-Nitro-L-arginine methyl ester hydrochloride (L-NAME) induced hypertension in adult male albino Wistar rats.
Before injecting vanillic acid, L-NAME (40 mg/kg Bw for 30 days) treated rats caused a sustained increase in systolic- (SBP) and diastolic blood pressure (DBP) and significantly decreased the concentration of nitrite/nitrate (NO(x)) in plasma, compared to the control.
However, rats treated with VA restored SBP and DBP to a normal level and preserved the plasma NO metabolites concentration.
Moreover, the VA also improved the antioxidant and non-antioxidant enzymes and lipid reduced lipid peroxidation expression in the plasma of the tested rats.
VA thiobarbituric acid reactive substances, lipid hydroperoxides, conjugated dienes) and significantly restored enzymatic antioxidants (superoxide dismutase, catalase, and glutathione peroxidase), non-enzymatic antioxidants (vitamin C, vitamin E, and reduced glutathione) in the plasma.
More precisely, the effect at a dose of 50 mg/kg Bw of VA was more pronounced than that of 25 and 100 mg/kg Bw.
Based on the findings, researchers said, " VA possesses an antihypertensive and antioxidant activity in L-NAME-induced hypertensive rats".
Taken altogether, Comfrey may be considered a remedy for the treatment of hypertension, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antihypertensive and antioxidant potential of vanillic acid, a phenolic compound in L-NAME-induced hypertensive rats: a dose-dependence study by Kumar S1, Prahalathan P, Raja B. (PubMed)
Hypertension or high blood pressure is a condition characterized by persistent high blood pressure.
In the US approximately, one-third of the adults have high blood pressure, affecting over 77 million people in the country.
Additionally, among adults age 20 and older in the United States, in the non-Hispanic whites community, 33.4 percent of men and 30.7 percent of women are infected by the syndrome.
High blood pressure is a slowly developed condition. Unless the syndrome has caused damage to the blood vessel, otherwise symptoms cannot be detected.
The cause of high blood pressure is a result of hardening and thickening of the arteries (atherosclerosis), due to the slow progression of plaques accumulated on the wall of the arteries.
High blood pressure can be acute or chronic. Acute high blood pressure most often occurs to people with sudden stress.
Acute high blood pressure can be caused by intense physical exercise. As the heart must pump harder to provide the needs of nutrients and oxygen.
Most cases of chronic high blood pressure are associated with an unhealthy lifestyle and chronic diseases such as kidney disease, leading to the onset of strokes and cardiovascular disease.
Abnormal high blood pressure, depending on how high of the numbers, patients may experience symptoms of a headache to a severe headache., fatigue, vision problems. However, in severe cases, high blood pressure can also induce chest pain, difficulty breathing, irregular heartbeat and confusion.
Untreated high blood pressure epidemiologically can cause complications of retinopathy, lead to damage to the retina or bleeding in the eye, blurred vision and complete loss of vision.
Cleaver is a herbaceous annual plant, genus Galium, belonging to the family Rubiaceae, native to North America and Eurasia. The herb has been used over thousands of years in herbal and traditional medicine as mild diuretic and blood and lymphatic cleanser and to treat psoriasis, skin conditions, glands, tonsillitis, bladder infections, prevent small kidney stone, etc.
On finding a potential compound for the prevention and treatment of cardiovascular diseases (CVD), researchers investigated the antihypertensive and antioxidant potential of vanillic acid (VA) found in cleaver, in N(ω)-Nitro-L-arginine methyl ester hydrochloride (L-NAME) induced hypertension in adult male albino Wistar rats.
Before injecting vanillic acid, L-NAME (40 mg/kg Bw for 30 days) treated rats caused a sustained increase in systolic- (SBP) and diastolic blood pressure (DBP) and significantly decreased the concentration of nitrite/nitrate (NO(x)) in plasma, compared to the control.
However, rats treated with VA restored SBP and DBP to a normal level and preserved the plasma NO metabolites concentration.
Moreover, the VA also improved the antioxidant and non-antioxidant enzymes and lipid reduced lipid peroxidation expression in the plasma of the tested rats.
VA thiobarbituric acid reactive substances, lipid hydroperoxides, conjugated dienes) and significantly restored enzymatic antioxidants (superoxide dismutase, catalase, and glutathione peroxidase), non-enzymatic antioxidants (vitamin C, vitamin E, and reduced glutathione) in the plasma.
More precisely, the effect at a dose of 50 mg/kg Bw of VA was more pronounced than that of 25 and 100 mg/kg Bw.
Based on the findings, researchers said, " VA possesses an antihypertensive and antioxidant activity in L-NAME-induced hypertensive rats".
Taken altogether, Comfrey may be considered a remedy for the treatment of hypertension, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Antihypertensive and antioxidant potential of vanillic acid, a phenolic compound in L-NAME-induced hypertensive rats: a dose-dependence study by Kumar S1, Prahalathan P, Raja B. (PubMed)
Herbal Cramp Bark (Vib urnum opulus), the Anti-Endometriosis Functional Herb
Endometriosis is a painful disorder characterized by endometrial cells that grow in other areas in the reproductive organs, such as ovaries, fallopian tubes,..... and the tissue lining your pelvis, outside of the uterus.
Most cases of endometriosis are in the organs in the pelvic area, including ovaries and fallopian tubes.
Endometriosis also reacts to hormone signals of the monthly menstrual cycle, by building and breaking up tissues and eliminating them through the menstrual period.
According to the statistics provided by the Clinical Center of Niš,
* About 20% of reproductive-age women with endometriosis are asymptomatic
* About 55% of women have developed the new onset of severe menstrual cramps
* About 25% of women with sub-fertility (less fertile than a normal couple), depending on the stages of endometriosis.
Endometriosis can be classified into 4 stages
* Minimal stage
The top surface, few in number. Commonly they are found in the inside wall of uterus, ligaments, and ovary, causing a significant reduction in both progesterone and its ratio with 17 beta-oestradiol, luteal dysfunction and abnormal secretory patterns(3). Minimal stage endometriosis may lead to unexplained causes of infertility(2).
* Mild stage
Deeper implants, greater numbers are presented. Commonly found in the same area as a minimal stage, causing worsening of oocyte quality. The mild stage of endometriosis may lead to infertility(4).
* Moderate stage:
Many implants, endometrial cysts are presented, affecting ovary function, and causing scar tissues and adhesion.
* Severe stage:
Intensive peritoneal implants, large endometriomas are presented with dense adhesion.
Conventionally, most cases of endometriosis are treated by pain medicines such as NSAIDs (non-steroidal anti-inflammatory drugs) and hormone therapy such as birth control pills with an aim to reduce pain and improve quality of life, including daily activity.
Cramp Bark is an ornamental plant, genus Viburnum, belonging to the family Adoxaceae, native to Europe and Asia. It has been used in traditional and herbal medicine as anti-spasmodic, anti-inflammatory, nervine. hypotensive agent and to treat menstrual cramps and pain, afterbirth, postpartum pains, excessive blood loss in periods, bleeding associated with the menopause, etc.
On finding a potential herbal medicine for the treatment of menstrual disorders, researchers examined
the effects of cramp-bark on endometriosis in an animal model.
In the endometriosis induced by suturing 15mm piece of the endometrium into the abdominal wall of Sprague Dawley rats, air-dried, powdered fruits of V. Opulus extracts sequentially with n-hexane, ethyl acetate (EtOAc), and methanol (MeOH) showed a strong effect in reducing the endometriotic volumes.
In other words, the EtOAc and MeOH extract-administered group showed a decreased of endometrial volumes to 30.1mm3 and 34.7mm3, compared to the control group, respectively.
Furthermore, EtOAc groups showed no endometrial adhesion.
Moreover, according to the histopathological data both EtOAc and MeOH extract-administered groups displayed significant remission in the levels of pro-inflammatory cytokines, compared to control.
The chemical compound associated with the anti endometriosis activity was found to be chlorogenic acid, according to HPLC analysis.
Based on the results, researchers said, "the effectiveness of the fruit extract of V. Opulus could be partially attributed chlorogenic acid. Other phenolic compounds could potentiate the activity due to their amount".
Cramp Bark(Viburnum opulus) may be considered an anti endometriosis remedy, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You. How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Viburnum opulus L.: A remedy for the treatment of endometriosis demonstrated by rat model of surgically-induced endometriosis by Saltan G1, Süntar I2, Ozbilgin S1, Ilhan M2, Demirel MA3, Oz BE1, Keleş H4, Akkol EK. (PubMed)
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