Cancer is a group of diseases characterized by the irregular cell growth on the body tissue, due to the alternation of cell DNA.
Most cases of cancer start in the cell on the surface of the inner lining tissue and do not exert any symptoms at the early stage.
At the later stage, the larger size tumor may press on the nearby blood vessels and nerve cells, causing localized severe bleeding and pain accompanied by the general symptoms of cancers, including the unintended weight loss, loss of appetite, fatigue and tiredness and gastrointestinal problems.
Most cancer cells at this stage can also travel a distance away from the original site to affect other healthy tissue and organs, leading to secondary metastasis.
Pre-cancer is a medical condition that likely develops into cancer if untreated.
Monoclonal gammopathy of undetermined significance (MGUS) is a precancerous condition and the most common plasma cell disorder.
In other words, monoclonal myeloma gammopathies is a precancerous condition that may cause myeloma, a cancer of white blood cell disorder.
Multiple myelomas. also known as plasma cell myeloma or Kahler's disease, is a type of abnormal growth of plasma cells collected in the none marrow where they grow and multiply to interfere with the production of normal blood cells.
According to the study by the Harvard Medical School, paraprotein, an abnormal antibody produced by the plasma cell myeloma not only can cause kidney problem but also interference with the Roche automated total bilirubin, including total bilirubin (TBIL), direct bilirubin (DBIL), or HDL-cholesterol (HDL-C).
Ashwagandha also is known as Withania somnifera is a nightshade plant in the genus of Withania, belonging to the family Solanaceae, native to the dry parts of India, North Africa, Middle East, and the Mediterranean.
The herbal medicine has been considered as Indian ginseng and used in Ayurvedic medicine over 3000 years to treat tumors and tubercular glands, carbuncles, memory loss, and ulcers and considered as anti-stress, cognition-facilitating, anti-inflammatory, and anti-aging herbal medicine.
On finding a potent compound that processes the anti-cancer property, researchers examined the effects of Withaferin A (WA) isolated from the plant Withania somnifera, antitumor effects on a multiple myeloma cell model.
According to the results from Ingenuity Pathway Analysis and Western blot, WA exerted a significant action against monoclonal gammopathy of undetermined significance (MGUS) and related disorders.
Furthermore, WA showed a strong and massive blockage on both proteotoxic and oxidative stress response pathways by targeting protein networks such as multicatalytic proteinase complex, associated with the risk of monoclonal gammopathy.
In other words, WA mediated apoptosis is preceded by simultaneous targeting of cellular stress response pathways like proteasome degradation, autophagy and unfolded protein stress response.
Based on the findings, researchers said, "the combined approach can be used for other types of cancer and/or other promising multifunctional compounds, thereby increasing the potential development of new antitumor therapies".
Taken altogether, Ashwagandhaprocessed abundantly WA may be considered a functional herb for the modulation of the monoclonal myeloma gammopathies, pending to the result of larger sample size and multicenter study
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Proteomic characterization of Withaferin A-targeted protein networks for the treatment of monoclonal myeloma gammopathies by Dom M1, Offner F2, Vanden Berghe W1, Van Ostade X. (PubMed)
(2) Multiple Myeloma by Kyle J. Norton
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