Scientists from the respectable institution may have found an ingredient from herbal chamomile for the treatment of Gastric ulcers with little or no side effects.
According to the King Khalid University, in ethanol-induced Gastric ulcers, Chamomilla Recutita (ACE), exhibited the expression of the antioxidant glutathione in regulation of the herbal mediated effect on the gastric ulcer.
Dr. Al-Hashem FH, the author of the study, said," Compared to non-ACE treated rats, the ulcer index (UI) decreased significantly in a dose-dependent manner in treated animals" and " glutathione(GSH) levels fell significantly after ethanol treatment; this decrease was prevented by ACE treatment".
Gastric ulcer, a type of peptic ulcer is a condition of localized tissue erosion in the lining the stomach, inducing symptoms of abdominal pain, bloating, septic shock, Dyspepsia, Blood in stool, bleeding, etc.
Chamomile is also known as camomile, the common name of many species daisy-like plants in the family Asteraceae, used in traditional medicine as antispasmodic and anti-inflammatory constituents and to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.
The herbal medicine Alpha-bisabolol, a bioactive component, in the animal study also inhibited gastric mucosal damage. Oral doses of 50 and 100 mg=kg markedly attenuated the gastric lesions induced by ethanol to the extent of 87% and 96% in the activation of cellular metabolism.
Furthermore, the commercial preparation (STW 5, Iberogast), containing the extracts of bitter candy tuft, lemon balm leaf, chamomile flower, caraway fruit, peppermint leaf, licorice root, Angelica root, milk thistle fruit and greater celandine herb, tested in patients with gastric ulcer, not only lower the gastric acidity but also inhibited the secondary hyperacidity.
In ethanol-induced acute gastric mucosal injury in rats, Matricaria chamomilla L. (Compositae) hydroalcoholic extract (MCE) exerted a protective effect against ethanol-induced gastric mucosal lesions, depending upon the reduction in lipid peroxidation and augmentation in antioxidant activity. Dr. Cemek M, the lead researcher at the Afyon Kocatepe University suggested.
There is no doubt that chamomile and combination of chamomile with other herbal medicines are found to express gastrointestinal effects in reduced risk and treatment of gastric ulcers. But effective doses should only be prescribed by herbalists to prevent toxicity.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Gastroprotective effects of aqueous extract of Chamomilla recutita against ethanol-induced gastric ulcers by Al-Hashem FH1.(PubMed)
(2) Bisabolol-induced gastroprotection against acute gastric lesions: role of prostaglandins, nitric oxide, and KATP+ channels by Bezerra SB1, Leal LK, Nogueira NA, Campos AR.(PubMed)
(3) Mechanisms involved in the gastro-protective effect of STW 5 (Iberogast) and its components against ulcers and rebound acidity by Khayyal MT1, Seif-El-Nasr M, El-Ghazaly MA, Okpanyi SN, Kelber O, Weiser D.(PubMed)
Thursday, March 26, 2020
Wednesday, March 25, 2020
Herbal Turmeric, the Natural Prevention and Treatment of Diabetic Complications
Diabetes is a chronic and medical condition characterized by the inability of the body to use insulin to convert glucose in the bloodstream to energy.
In other words, diabetes is a result of insufficient insulin entering the bloodstream to regulate glucose caused by either a reduced number of beta cells in the pancreas or insulin receptor site clogged up with fat or cholesterol.
Diabetic complications are any diseases associated with hyperglycemia if the blood glucose is not managed properly. Patients with diabetes may induce a number of complications including cardiovascular disease, neuropathy, nephropathy, retinopathy, and foot ulcer.
By managing your blood glucose properly and daily, the risk of diabetic complications can be reduced in diabetics by
*Taking your medication as directed.
*Keeping tight control of your blood sugar or managing the blood glucose in the required range
* Eating healthy with moderate exercise to protect your weight, blood pressure and cholesterol. Overweight, blood pressure and cholesterol are some of the conditions associated with increased risk of diabetes complications.
* Get regular checkups
* Quit smoking
If you are following the aforementioned suggestion, you may do just fine in the prevention of diabetes complications.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to find a potential ingredient for the prevention of diabetic complications, researchers examined the effect of curcumin plethora of biologic and pharmacologic properties associated with antioxidant and anti-inflammatory activities.
Curcumin protected diabetics by its pleiotropic regulation of redox balance of cell and inflammation
In other words, curcumin exerted its diabetic complications by induction of various pathologic conditions, including detoxification and anti-inflammation.
In vivo, curcumin protected the diabetes-induced animal by protecting the micro-vascular function against the onset of coronary microvascular disease.
Dr. Jeenger MK, the lead scientist after taking into account co and confounders, SAID, "the importance of curcumin in addition to the existing therapeutic modalities in diabetic complications".
Taken altogether, turmeric may be considered a supplement for the prevention and treatment of diabetic complications, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Therapeutic potential of curcumin in diabetic complications by Parsamanesh N1, Moossavi M1, Bahrami A2, Butler AE3, Sahebkar A. (PubMed)
(2) Curcumin: a pleiotropic phytonutrient in diabetic complications by Jeenger MK1, Shrivastava S1, Yerra VG1, Naidu VG1, Ramakrishna S2, Kumar A. (PubMed)
In other words, diabetes is a result of insufficient insulin entering the bloodstream to regulate glucose caused by either a reduced number of beta cells in the pancreas or insulin receptor site clogged up with fat or cholesterol.
Diabetic complications are any diseases associated with hyperglycemia if the blood glucose is not managed properly. Patients with diabetes may induce a number of complications including cardiovascular disease, neuropathy, nephropathy, retinopathy, and foot ulcer.
By managing your blood glucose properly and daily, the risk of diabetic complications can be reduced in diabetics by
*Taking your medication as directed.
*Keeping tight control of your blood sugar or managing the blood glucose in the required range
* Eating healthy with moderate exercise to protect your weight, blood pressure and cholesterol. Overweight, blood pressure and cholesterol are some of the conditions associated with increased risk of diabetes complications.
* Get regular checkups
* Quit smoking
If you are following the aforementioned suggestion, you may do just fine in the prevention of diabetes complications.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and for the treatment of flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to find a potential ingredient for the prevention of diabetic complications, researchers examined the effect of curcumin plethora of biologic and pharmacologic properties associated with antioxidant and anti-inflammatory activities.
Curcumin protected diabetics by its pleiotropic regulation of redox balance of cell and inflammation
In other words, curcumin exerted its diabetic complications by induction of various pathologic conditions, including detoxification and anti-inflammation.
In vivo, curcumin protected the diabetes-induced animal by protecting the micro-vascular function against the onset of coronary microvascular disease.
Dr. Jeenger MK, the lead scientist after taking into account co and confounders, SAID, "the importance of curcumin in addition to the existing therapeutic modalities in diabetic complications".
Taken altogether, turmeric may be considered a supplement for the prevention and treatment of diabetic complications, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplements should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Therapeutic potential of curcumin in diabetic complications by Parsamanesh N1, Moossavi M1, Bahrami A2, Butler AE3, Sahebkar A. (PubMed)
(2) Curcumin: a pleiotropic phytonutrient in diabetic complications by Jeenger MK1, Shrivastava S1, Yerra VG1, Naidu VG1, Ramakrishna S2, Kumar A. (PubMed)
Tuesday, March 24, 2020
Herbal Cascara Sagrada (Rhamnus purshiana), the Anti Breast Cancer Functional Herb
Herbal Cascara sagrada may be the next generation of natural chemotherapy for the treatment of breast cancer, according to studies.
Breast cancer is a medical and chronic condition characterized by cell growth irregularly due to the alternation of DNA.
Most cases of breast cancer start in the cells on the surface of the inner lining of the breast tissue, including the milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
At the advanced, the large tumor may press on the nearby blood vessels and nerve cells, leading bleeding and severe pain. Cancer cells from the breast can also travel a distance away to infect other healthy tissue and organs at this stage.
The most common breast cancer secondary metastasis is the liver, brain, bones, or lungs.
According to the statistics, in 2010, over 250,000 new cases of breast cancer were diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during a lifetime of a woman is 1/8.
Researchers do not know the exact causes of breast cancer. However, family and personal history, women with dense breast tissue, use of hormone replacement therapy and oral contraceptives, genetic preposition, particularly BRCA1 and 2, tall adult heigh are some prevalent risk factors of the disease.
Some researchers suggested that the increase in the prevalence of breast cancer in overweight and obesity is also a major concern of the scientists' community.
Dr. Manuel Picon‐Ruiz, the lead scientists in the observation of obesity in risk of breast cancer wrote, "Obesity is associated both with a higher risk of developing breast cancer, particularly in postmenopausal women, and with worse disease outcome for women of all ages" and "... the effects of obesity to increase local and circulating proinflammatory cytokines, promote tumor angiogenesis and stimulate the most malignant cancer stem cell population to drive cancer growth, invasion, and metastasis".
And, "The effects of recent lifestyle interventions to decrease sex steroids, insulin/insulin‐like growth factor‐1 pathway activation and inflammatory biomarkers associated with worse breast cancer outcomes in obesity also are discussed. Although many observational studies indicate that exercise with weight loss is associated with improved breast cancer outcome".
The results strongly suggested that the risk of breast cancer is significantly elevated in the obese population compared to healthy adults.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America, it's bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc.
The chemical constituents of Cascara Sagrada include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A, B, C and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones palmidin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.
Researchers on clarification of the effects of a bioactive ingredient emodin found abundantly in herbal Cascara Sagrada and Rhubarb. against breast cancer, examined the compound activity on estrogen receptor α (ERα).
Application of emodin demonstrated the capability in inhibiting breast cancer cell proliferation by suppressing the ER α protein levels, by blocking the ER α transcriptional activation.
Furthermore, emodin treatment led to the dissociation of heat shock protein 90 (HSP90) which plays a critical role in stabilizing the proteins against heat stress and ER α and increased ER α ubiquitination in initiation cell degradation.
Dr. Huang PH and colleagues in the final report wrote, "emodin,....specifically suppress breast cancer cell proliferation by targeting ER α protein stability through distinct mechanisms".
In order to reveal the additional information of emodin in the inhibition of breast cancer, researchers investigated the anticancer effects of emodin on growth inhibition, apoptosis induction and the expression of apoptosis-related genes in MCF-7 cells.
Emodin showed significant growth inhibitory effects on MCF-7 cells with IC₅₀ = 7.22 µg/ml (∼30 μM) and exerted a concentration-dependent inhibitory effect on the colony-forming ability of MCF-7 cells with IC₅₀ = 7.60 µg/ml (∼30 µM).
The bioactive compound induced breast cancer death observed by the single-strand DNA breakage and DNA fragmentation, in emodin-treated MCF-7 cells.
Moreover, emodin efficacy in causing breast cancer cell apoptosis was attributed to the activation of the gene expression involved the modulation of the immune response to stress and inhibition of the proteins associated with cancer cell proliferation and survival.
Dr. Li WY, the lead scientist after taking into account co and confounders said, "emodin could induce growth inhibition and apoptosis in MCF-7 cells through the modulation of the expression of apoptosis-related genes".
Taken altogether, herbal Cascara Sagrada (Rhamnus purshiana) processed bioactive emodin may be considered a functional remedy for the prevention and combined with primary therapy for the treatment of breast cancer, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Emodin and Aloe-Emodin Suppress Breast Cancer Cell Proliferation through ER α Inhibition, byHuang PH, Huang CY, Chen MC, Lee YT, Yue CH, Wang HY, Lin H.(PubMed)
(2) Synergistic effects of curcumin with emodin against the proliferation and invasion of breast cancer cells through upregulation of miR-34a. by Guo J, Li W, Shi H, Xie X, Li L, Tang H, Wu M, Kong Y, Yang L, Gao J, Liu P, Wei W, Xie X.(PubMed)
(3) Emodin induces cytotoxic effect in human breast carcinoma MCF-7 cell through modulating the expression of apoptosis-related genes by Li WY, Chan RY, Yu PH, Chan SW.(PubMed)
(4) Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention by Manuel Picon‐Ruiz, PhD, 1 Cynthia Morata‐Tarifa, PhD, 2 Janeiro J. Valle‐Goffin, MD, 3Eitan R. Friedman, MD, 4 and Joyce M. Slingerland, MD, PhD. (PMC)
Breast cancer is a medical and chronic condition characterized by cell growth irregularly due to the alternation of DNA.
Most cases of breast cancer start in the cells on the surface of the inner lining of the breast tissue, including the milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk.
At the advanced, the large tumor may press on the nearby blood vessels and nerve cells, leading bleeding and severe pain. Cancer cells from the breast can also travel a distance away to infect other healthy tissue and organs at this stage.
The most common breast cancer secondary metastasis is the liver, brain, bones, or lungs.
According to the statistics, in 2010, over 250,000 new cases of breast cancer were diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during a lifetime of a woman is 1/8.
Researchers do not know the exact causes of breast cancer. However, family and personal history, women with dense breast tissue, use of hormone replacement therapy and oral contraceptives, genetic preposition, particularly BRCA1 and 2, tall adult heigh are some prevalent risk factors of the disease.
Some researchers suggested that the increase in the prevalence of breast cancer in overweight and obesity is also a major concern of the scientists' community.
Dr. Manuel Picon‐Ruiz, the lead scientists in the observation of obesity in risk of breast cancer wrote, "Obesity is associated both with a higher risk of developing breast cancer, particularly in postmenopausal women, and with worse disease outcome for women of all ages" and "... the effects of obesity to increase local and circulating proinflammatory cytokines, promote tumor angiogenesis and stimulate the most malignant cancer stem cell population to drive cancer growth, invasion, and metastasis".
And, "The effects of recent lifestyle interventions to decrease sex steroids, insulin/insulin‐like growth factor‐1 pathway activation and inflammatory biomarkers associated with worse breast cancer outcomes in obesity also are discussed. Although many observational studies indicate that exercise with weight loss is associated with improved breast cancer outcome".
The results strongly suggested that the risk of breast cancer is significantly elevated in the obese population compared to healthy adults.
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America, it's bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc.
The chemical constituents of Cascara Sagrada include Aloe-emodin, Anthrquinone glycosides (Barbaloin Cascarosides A, B, C and D ChrysaloinFrangul), Chrysophanol, Emodin, Heterodianthrones palmidin A, B, and C, dianthrones, Oxanthrone, Rhein, Tannins, etc.
Researchers on clarification of the effects of a bioactive ingredient emodin found abundantly in herbal Cascara Sagrada and Rhubarb. against breast cancer, examined the compound activity on estrogen receptor α (ERα).
Application of emodin demonstrated the capability in inhibiting breast cancer cell proliferation by suppressing the ER α protein levels, by blocking the ER α transcriptional activation.
Furthermore, emodin treatment led to the dissociation of heat shock protein 90 (HSP90) which plays a critical role in stabilizing the proteins against heat stress and ER α and increased ER α ubiquitination in initiation cell degradation.
Dr. Huang PH and colleagues in the final report wrote, "emodin,....specifically suppress breast cancer cell proliferation by targeting ER α protein stability through distinct mechanisms".
In order to reveal the additional information of emodin in the inhibition of breast cancer, researchers investigated the anticancer effects of emodin on growth inhibition, apoptosis induction and the expression of apoptosis-related genes in MCF-7 cells.
Emodin showed significant growth inhibitory effects on MCF-7 cells with IC₅₀ = 7.22 µg/ml (∼30 μM) and exerted a concentration-dependent inhibitory effect on the colony-forming ability of MCF-7 cells with IC₅₀ = 7.60 µg/ml (∼30 µM).
The bioactive compound induced breast cancer death observed by the single-strand DNA breakage and DNA fragmentation, in emodin-treated MCF-7 cells.
Moreover, emodin efficacy in causing breast cancer cell apoptosis was attributed to the activation of the gene expression involved the modulation of the immune response to stress and inhibition of the proteins associated with cancer cell proliferation and survival.
Dr. Li WY, the lead scientist after taking into account co and confounders said, "emodin could induce growth inhibition and apoptosis in MCF-7 cells through the modulation of the expression of apoptosis-related genes".
Taken altogether, herbal Cascara Sagrada (Rhamnus purshiana) processed bioactive emodin may be considered a functional remedy for the prevention and combined with primary therapy for the treatment of breast cancer, pending to the confirmation of large sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
References
(1) Emodin and Aloe-Emodin Suppress Breast Cancer Cell Proliferation through ER α Inhibition, byHuang PH, Huang CY, Chen MC, Lee YT, Yue CH, Wang HY, Lin H.(PubMed)
(2) Synergistic effects of curcumin with emodin against the proliferation and invasion of breast cancer cells through upregulation of miR-34a. by Guo J, Li W, Shi H, Xie X, Li L, Tang H, Wu M, Kong Y, Yang L, Gao J, Liu P, Wei W, Xie X.(PubMed)
(3) Emodin induces cytotoxic effect in human breast carcinoma MCF-7 cell through modulating the expression of apoptosis-related genes by Li WY, Chan RY, Yu PH, Chan SW.(PubMed)
(4) Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention by Manuel Picon‐Ruiz, PhD, 1 Cynthia Morata‐Tarifa, PhD, 2 Janeiro J. Valle‐Goffin, MD, 3Eitan R. Friedman, MD, 4 and Joyce M. Slingerland, MD, PhD. (PMC)
Monday, March 23, 2020
Green Tea Polyphenols (GrTPs), the Bioactive Ingredient Which Protects Sperm Quality and Integrity Against Infertility, Scientists Find
Scientists may have found a beverage bioactive compound that protects the sperm quality and integrity, without inducing any side effects, some studies found,
Infertility is a condition characterized by the inability to get pregnant after 12 months of frequent and unprotected sex of a couple. Women who cannot carry the pregnancy to term are also considered as infertile.
According to the statistic, approximately 10% of women in their reproductive years are having the difficulty of conceiving or carrying the pregnancy to term.
The most common causes of infertility in men are low sperm count, sperm motility and abnormal sperm.
What causes abnormal sperm production is unknown. Researchers do not know why people with the same health conditions and family history, are having abnormal sperm production while others do not.
However, researchers do not that certain prevalent risk factors including physical and medical conditions, such as undescended testicle and diabetes long-term intakes of a certain medicine, such as anti-inflammatory drug and hormone imbalance such as testosterone deficiency are associated with abnormal sperm production.
Genetic preposition such as chromosomal conditions that affect sperm production also plays a major role in elevating the onset of abnormal sperm production.
Age, obesity, use of illicit drugs, excessive alcohol drinking and long-term exposure to chemicals are the common causes of abnormal sperm production.
In term of diet, researchers at the Harvard T.H. Chan School of Public Health in the study "Diet and men's fertility: does diet affect sperm quality?" wrote, "men may be encouraged to use antioxidant supplements and to follow dietary patterns favoring the consumption of seafood, poultry, nuts, whole grains, fruits, and vegetables. Evidence is strongest for recommending the use of antioxidant supplements to men in couples undergoing infertility treatment-although the specific antioxidants and doses remain unclear-and increasing consumption of omega-3 fatty acids from fish and nuts".
These results suggested that men who follow the diet with high in saturated and trans fat, intake of a large amount of red meat and processed food and less in fruits, nuts and vegetables are at a higher risk of sperm abnormality.
In the concerns of highly sensitive of sperm cells to reactive oxygen species (ROS), which are produced during cellular oxidation, researchers at the joint study led by the Anhui Agricultural University launched an investigation to examine the green tea polyphenols (GrTPs) effect in the protection of the integrity of the sperm.
Before the application of green tea s (GrTPs) researchers found that oxidative stress has numerous effects, in the increased apoptosis, reduced motion parameters, and sperm integrity in the tested subjects with overexpression of free radicals.
The increased ROS levels probably are the results of antioxidant enzymes produced by the tested subjects being suppressed due to some unknown mechanisms.
Oral administered green tea polyphenols (GrTPs), showed to restore and increase the quality of male gametes, mostly via the capability of catechins in the reduction of ROS production.
Further analysis also suggested that GrTPs processed antioxidant properties that not only restore the abnormal sperm production caused by overexpression of ROS but also improve major semen parameters, such as sperm concentration, motility, morphology, DNA damage, fertility rate, and gamete quality.
These unique properties of green tea catechins in improving the male reproductive health suggested green tea polyphenols (GrTPs) may be considered a functional food in reducing the risk of abnormal sperm quality in many parameters.
Dr, Rahman SU, the lead scientist at the final report, said, "the therapeutic effects of GrTPs against infertility, their possible mechanisms of action, and recommended supportive therapy for improving fertility in humans and in animals".
Additionally, in the concerns of the reactive oxygen species (ROS) presented in high concentrations in the genital tracts of males that affects compromised vitality, increased morphological defects and decreased sperm motility, researchers launched an investigation to examine whether green tea catechins protect the sperm quality and integrity over the expression of ROS.
After taking into account levels of oxidative stress before and after the application of green tea catechin, researchers wrote,
* Epigallocatechin-3-gallate (EGCG), a major bioactive compound in green tea inhibited the expression of ROS through its strong antioxidant activity.
* Green tea catechins potentially improve sperm quality and integrity.
Dr. Roychoudhury S, the lead author said, " (These results furtherly confirmed) the potential roles of green tea catechins on oxidative stress in male and female reproduction and fertility".
Taken altogether, Green tea polyphenols (GrTPs) may be considered an adjunct therapy in the protection of the male reproductive sperm quality and integrity against the onset of infertility.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Diet and men's fertility: does diet affect sperm quality? by Nassan FL1, Chavarro JE2, Tanrikut C. (PubMed)
(2) Therapeutic Role of Green Tea Polyphenols in Improving Fertility: A Review by Rahman SU1, Huang Y2, Zhu L3, Feng S4, Khan IM5, Wu J6, Li Y7, Wang X8.(PubMed)
(3) Potential role of green tea catechins in the management of oxidative stress-associated infertility by Roychoudhury S1, Agarwal A2, Virk G3, Cho CL. (PubMed)
Infertility is a condition characterized by the inability to get pregnant after 12 months of frequent and unprotected sex of a couple. Women who cannot carry the pregnancy to term are also considered as infertile.
According to the statistic, approximately 10% of women in their reproductive years are having the difficulty of conceiving or carrying the pregnancy to term.
The most common causes of infertility in men are low sperm count, sperm motility and abnormal sperm.
What causes abnormal sperm production is unknown. Researchers do not know why people with the same health conditions and family history, are having abnormal sperm production while others do not.
However, researchers do not that certain prevalent risk factors including physical and medical conditions, such as undescended testicle and diabetes long-term intakes of a certain medicine, such as anti-inflammatory drug and hormone imbalance such as testosterone deficiency are associated with abnormal sperm production.
Genetic preposition such as chromosomal conditions that affect sperm production also plays a major role in elevating the onset of abnormal sperm production.
Age, obesity, use of illicit drugs, excessive alcohol drinking and long-term exposure to chemicals are the common causes of abnormal sperm production.
In term of diet, researchers at the Harvard T.H. Chan School of Public Health in the study "Diet and men's fertility: does diet affect sperm quality?" wrote, "men may be encouraged to use antioxidant supplements and to follow dietary patterns favoring the consumption of seafood, poultry, nuts, whole grains, fruits, and vegetables. Evidence is strongest for recommending the use of antioxidant supplements to men in couples undergoing infertility treatment-although the specific antioxidants and doses remain unclear-and increasing consumption of omega-3 fatty acids from fish and nuts".
These results suggested that men who follow the diet with high in saturated and trans fat, intake of a large amount of red meat and processed food and less in fruits, nuts and vegetables are at a higher risk of sperm abnormality.
In the concerns of highly sensitive of sperm cells to reactive oxygen species (ROS), which are produced during cellular oxidation, researchers at the joint study led by the Anhui Agricultural University launched an investigation to examine the green tea polyphenols (GrTPs) effect in the protection of the integrity of the sperm.
Before the application of green tea s (GrTPs) researchers found that oxidative stress has numerous effects, in the increased apoptosis, reduced motion parameters, and sperm integrity in the tested subjects with overexpression of free radicals.
The increased ROS levels probably are the results of antioxidant enzymes produced by the tested subjects being suppressed due to some unknown mechanisms.
Oral administered green tea polyphenols (GrTPs), showed to restore and increase the quality of male gametes, mostly via the capability of catechins in the reduction of ROS production.
Further analysis also suggested that GrTPs processed antioxidant properties that not only restore the abnormal sperm production caused by overexpression of ROS but also improve major semen parameters, such as sperm concentration, motility, morphology, DNA damage, fertility rate, and gamete quality.
These unique properties of green tea catechins in improving the male reproductive health suggested green tea polyphenols (GrTPs) may be considered a functional food in reducing the risk of abnormal sperm quality in many parameters.
Dr, Rahman SU, the lead scientist at the final report, said, "the therapeutic effects of GrTPs against infertility, their possible mechanisms of action, and recommended supportive therapy for improving fertility in humans and in animals".
Additionally, in the concerns of the reactive oxygen species (ROS) presented in high concentrations in the genital tracts of males that affects compromised vitality, increased morphological defects and decreased sperm motility, researchers launched an investigation to examine whether green tea catechins protect the sperm quality and integrity over the expression of ROS.
After taking into account levels of oxidative stress before and after the application of green tea catechin, researchers wrote,
* Epigallocatechin-3-gallate (EGCG), a major bioactive compound in green tea inhibited the expression of ROS through its strong antioxidant activity.
* Green tea catechins potentially improve sperm quality and integrity.
Dr. Roychoudhury S, the lead author said, " (These results furtherly confirmed) the potential roles of green tea catechins on oxidative stress in male and female reproduction and fertility".
Taken altogether, Green tea polyphenols (GrTPs) may be considered an adjunct therapy in the protection of the male reproductive sperm quality and integrity against the onset of infertility.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Diet and men's fertility: does diet affect sperm quality? by Nassan FL1, Chavarro JE2, Tanrikut C. (PubMed)
(2) Therapeutic Role of Green Tea Polyphenols in Improving Fertility: A Review by Rahman SU1, Huang Y2, Zhu L3, Feng S4, Khan IM5, Wu J6, Li Y7, Wang X8.(PubMed)
(3) Potential role of green tea catechins in the management of oxidative stress-associated infertility by Roychoudhury S1, Agarwal A2, Virk G3, Cho CL. (PubMed)
Sunday, March 22, 2020
Herbal Cayenne, The Best Whole Herb Medicine for Prevention and Treatment of Liver Cancer
Capsaicin (8-methyl-N-vanillyl-6-nonenamide), a major ingredient found in cayenne may be used as a supplement for protection against liver cancer.
According to a recent study by the Duksung Women's University, oral administration of Capsaicin inhibited HepG2 human hepatoblastoma cells, through its antioxidants activities in the induction of apoptosis in the oxidase-mediated generation of ROS.
Other studies insisted that cayenne exerted protection against liver cancer, is the result of inhibition of cancer cell proliferation, migration and invasion of tumors, and induced tumors to radiotherapy and chemotherapy.
Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belonging to Capsicum annuum, the family Solanaceae, native to subtropical and tropical regions, used in traditional medicine to increases metabolism, enhance circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises, and neuralgia, etc.
Liver cancer is a condition of out of controlled growth of hepatocellular cells in the liver. Since the organ is a soft tissue with less nerve, most liver cancer patients are diagnosed in the later stage of cancer. According to the statistic, liver cancer remains the fifth most common malignancy in men and the eighth in women worldwide.
Hepatocellular carcinoma (HCC) is a common form of primary liver cancer.
In a 4-wk feeding of B6C3F1 mice at 6 wk of age, oral intake of the cayenne group expressed not the only bodyweight but also reduced hypoglycemia and cells involved in the generation of liver cancer.
Dr. Teel RW, author of the research said, " At concentrations of 25, 50, and 100 microM, capsaicin inhibited the biotransformation of (Aflatoxin B1(AFB1) produced by hepatitis viral) by modifying Phase I hepatic enzyme activity ( induced damage and injure of the liver) "
Furthermore, in the inhibition of toxical metabolism, capsaicin also possessed antimutagenic and anticarcinogenic properties against many types of cancer.
Taking all together, cayenne may process the anti liver cancer effect, but a large quantity intake should only be prescribed by herbalists.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Spices for Prevention and Treatment of Cancers by Zheng J1, Zhou Y2, Li Y3, Xu DP4, Li S5, Li HB6,7.(PubMed)
(2) Involvement of NADPH oxidase-mediated generation of reactive oxygen species in the apototic cell death by capsaicin in HepG2 human hepatoma cells by Lee YS1, Kang YS, Lee JS, Nicolova S, Kim JA.(PubMed)
(3) A 4-week feeding study of ground red chilli (Capsicum annuum) in male B6C3F1 mice by Jang JJ1, Devor DE, Logsdon DL, Ward JM.(PubMed)
(4) Effects of capsaicin on rat liver S9-mediated metabolism and DNA binding of aflatoxin by Teel RW1.(PubMed)
According to a recent study by the Duksung Women's University, oral administration of Capsaicin inhibited HepG2 human hepatoblastoma cells, through its antioxidants activities in the induction of apoptosis in the oxidase-mediated generation of ROS.
Other studies insisted that cayenne exerted protection against liver cancer, is the result of inhibition of cancer cell proliferation, migration and invasion of tumors, and induced tumors to radiotherapy and chemotherapy.
Cayenne is also known as Cayenne Pepper, a red, hot chili pepper, belonging to Capsicum annuum, the family Solanaceae, native to subtropical and tropical regions, used in traditional medicine to increases metabolism, enhance circulatory system and stomach and the intestinal tract, adjust blood pressure, lower LDL cholesterol and triglycerides, treat frostbite, muscles, arthritis, rheumatism, low back pain, strains, sprains, bruises, and neuralgia, etc.
Liver cancer is a condition of out of controlled growth of hepatocellular cells in the liver. Since the organ is a soft tissue with less nerve, most liver cancer patients are diagnosed in the later stage of cancer. According to the statistic, liver cancer remains the fifth most common malignancy in men and the eighth in women worldwide.
Hepatocellular carcinoma (HCC) is a common form of primary liver cancer.
In a 4-wk feeding of B6C3F1 mice at 6 wk of age, oral intake of the cayenne group expressed not the only bodyweight but also reduced hypoglycemia and cells involved in the generation of liver cancer.
Dr. Teel RW, author of the research said, " At concentrations of 25, 50, and 100 microM, capsaicin inhibited the biotransformation of (Aflatoxin B1(AFB1) produced by hepatitis viral) by modifying Phase I hepatic enzyme activity ( induced damage and injure of the liver) "
Furthermore, in the inhibition of toxical metabolism, capsaicin also possessed antimutagenic and anticarcinogenic properties against many types of cancer.
Taking all together, cayenne may process the anti liver cancer effect, but a large quantity intake should only be prescribed by herbalists.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Spices for Prevention and Treatment of Cancers by Zheng J1, Zhou Y2, Li Y3, Xu DP4, Li S5, Li HB6,7.(PubMed)
(2) Involvement of NADPH oxidase-mediated generation of reactive oxygen species in the apototic cell death by capsaicin in HepG2 human hepatoma cells by Lee YS1, Kang YS, Lee JS, Nicolova S, Kim JA.(PubMed)
(3) A 4-week feeding study of ground red chilli (Capsicum annuum) in male B6C3F1 mice by Jang JJ1, Devor DE, Logsdon DL, Ward JM.(PubMed)
(4) Effects of capsaicin on rat liver S9-mediated metabolism and DNA binding of aflatoxin by Teel RW1.(PubMed)
Saturday, March 21, 2020
Garlic - The Whole Food Medicine for Reduced Risk and Treatment of Progression of Atherosclerosis
Recent study suggested that patients with atherosclerosis may be benefits from adding aged garlic extract with supplement into their diet.
According to the UCLA-School of Medicine, Los Angeles, the effectiveness of garlic in reduced homocysteine and progression of Atherosclerosis is the result of the changing white (wEAT) and brown (bEAT) epicardial adipose tissue(a form of visceral fat deposited around the heart) in plaque stabilization.
Garlic (Allium sativum) is a species in the onion genus, belonging to family Amaryllidaceae, native to central Asia, used popularly in traditional and Chinese medicine in treating common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotic, etc.
Atherosclerosis is a disease in which plaque builds up inside the arteries affecting the levels of oxygen in the blood as well as increased risks of heart attacks, strokes, and peripheral vascular disease.
In a placebo-controlled, double-blind, randomized trial (conducted 2005-2007), with 65 intermediate-risk patients (age 60+/-9 years, 79% male), patients treated with a capsule containing aged garlic extract (250 mg) plus Vitamin B12 (100 microg), folic acid (300 microg), Vitamin B6 (12.5 mg) and l-arginine (100 mg) daily for a 1 year are found to associate with a favorable improvement in oxidative biomarkers, vascular function, and reduced progression of atherosclerosis.
(AGE) has shown to retard the progression of coronary calcification in patients with coronary artery disease in vitro and vivo,
Dr. Morihara N, the lead author at the joint study said, " Antiatherosclerotic activity of AGE is at least partly due to the suppression of inflammation and lipid deposition in the vessels during the early stage of atherosclerotic development".
In a total of 157 healthy postmenopausal women (age 65 ± 6) randomized study, 500 mg isoflavonoid-rich herbal preparation, including garlic powder, showed to reduce risk of cardiovascular disease and atherosclerosis progression through lowering high blood cholesterol.
Although garlic prevents the development of cholesterol-induced experimental atherosclerosis and possesses direct anti-atherogenic activity, the intake of garlic supplements should be taken with care to patients with an ulcer.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Aged garlic extract with supplement is associated with increase in brown adipose, decrease in white adipose tissue and predict lack of progression in coronary atherosclerosis by Ahmadi N1, Nabavi V, Hajsadeghi F, Zeb I, Flores F, Ebrahimi R, Budoff M.(PubMed)
(2) Aged garlic extract supplemented with B vitamins, folic acid and L-arginine retards the progression of subclinical atherosclerosis: a randomized clinical trial by Budoff MJ1, Ahmadi N, Gul KM, Liu ST, Flores FR, Tiano J, Takasu J, Miller E, Tsimikas S.(PubMed)
(3) Aged Garlic Extract Suppresses the Development of Atherosclerosis in Apolipoprotein E-Knockout Mice by Morihara N1, Hino A2, Yamaguchi T3, Suzuki J3.(PubMed)
(4)
(5) Anti-atherosclerotic effects of garlic preparation in freeze injury model of atherosclerosis in cholesterol-fed rabbits by Sobenin IA1, Andrianova IV2, Lakunin KY3, Karagodin VP4, Bobryshev YV5, Orekhov AN6.(PubMed)
According to the UCLA-School of Medicine, Los Angeles, the effectiveness of garlic in reduced homocysteine and progression of Atherosclerosis is the result of the changing white (wEAT) and brown (bEAT) epicardial adipose tissue(a form of visceral fat deposited around the heart) in plaque stabilization.
Garlic (Allium sativum) is a species in the onion genus, belonging to family Amaryllidaceae, native to central Asia, used popularly in traditional and Chinese medicine in treating common cold and flu to the Plague, blood pressure cholesterol levels, natural antibiotic, etc.
Atherosclerosis is a disease in which plaque builds up inside the arteries affecting the levels of oxygen in the blood as well as increased risks of heart attacks, strokes, and peripheral vascular disease.
In a placebo-controlled, double-blind, randomized trial (conducted 2005-2007), with 65 intermediate-risk patients (age 60+/-9 years, 79% male), patients treated with a capsule containing aged garlic extract (250 mg) plus Vitamin B12 (100 microg), folic acid (300 microg), Vitamin B6 (12.5 mg) and l-arginine (100 mg) daily for a 1 year are found to associate with a favorable improvement in oxidative biomarkers, vascular function, and reduced progression of atherosclerosis.
(AGE) has shown to retard the progression of coronary calcification in patients with coronary artery disease in vitro and vivo,
Dr. Morihara N, the lead author at the joint study said, " Antiatherosclerotic activity of AGE is at least partly due to the suppression of inflammation and lipid deposition in the vessels during the early stage of atherosclerotic development".
In a total of 157 healthy postmenopausal women (age 65 ± 6) randomized study, 500 mg isoflavonoid-rich herbal preparation, including garlic powder, showed to reduce risk of cardiovascular disease and atherosclerosis progression through lowering high blood cholesterol.
Although garlic prevents the development of cholesterol-induced experimental atherosclerosis and possesses direct anti-atherogenic activity, the intake of garlic supplements should be taken with care to patients with an ulcer.
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Sources
(1) Aged garlic extract with supplement is associated with increase in brown adipose, decrease in white adipose tissue and predict lack of progression in coronary atherosclerosis by Ahmadi N1, Nabavi V, Hajsadeghi F, Zeb I, Flores F, Ebrahimi R, Budoff M.(PubMed)
(2) Aged garlic extract supplemented with B vitamins, folic acid and L-arginine retards the progression of subclinical atherosclerosis: a randomized clinical trial by Budoff MJ1, Ahmadi N, Gul KM, Liu ST, Flores FR, Tiano J, Takasu J, Miller E, Tsimikas S.(PubMed)
(3) Aged Garlic Extract Suppresses the Development of Atherosclerosis in Apolipoprotein E-Knockout Mice by Morihara N1, Hino A2, Yamaguchi T3, Suzuki J3.(PubMed)
(4)
(5) Anti-atherosclerotic effects of garlic preparation in freeze injury model of atherosclerosis in cholesterol-fed rabbits by Sobenin IA1, Andrianova IV2, Lakunin KY3, Karagodin VP4, Bobryshev YV5, Orekhov AN6.(PubMed)
Thursday, March 19, 2020
Herbal Cascara Sagrada and (Mastitis) inflammation of breast tissue
Cascara sagrada is a species of buckthorn, genus Rhamnus, belonging to the family Rhamnaceae, native to western North America, it's bark has been used in traditional medicine for gastrointestinal support. and it is thought to have a laxative and natural cleansing, etc., effect.
Mastitis is the inflammation of breast tissue, mostly caused by Staphylococcus aureus
The ingredients
Besides the main compound of anthraquinones, other compounds include anthraquinone glycosides, (emodin, frangulin, iso-emodin, aloe-emodin, and chrysophanol), rhein, aloin, malic acid, tannic acid, cascarosides A, B, C, and D, and hydroxy anthracene derivatives (HAD), etc.
The effects
Nanosilver particles (AAgNPs), a derivative of the chemical constituent of aloin found in Cascara Sagrada may be the potential target used as antibiotics for the treatment of infectious and inflammatory diseases, including mastitis. In the Staphylococcus aureus induced murine mastitis study of a total of 40 female mice were divided into five groups of eight animals each, Nanosilver particles (AAgNPs) is found to be effective (concentration of 21.8) than antibiotic as it exerted the anti-inflammatory activity in reducing white blood cell (poly-morpho nuclear cell) infiltration.Other chemical compound emodin found in the herb, in a study of the same but with lipopolysaccharide (LPS)-induced mastitis also found to significantly reduced infiltration of neutrophilic granulocyte. These results may be given the green light for the chemical compounds of Cascara Sagrada used as a novel treatment strategy for mastitis.
The Side effects
1. Cascara Sagrada can be liver toxic.
2. It may cause Postal hypertension
Cascara sagrada (CS) has been associated with the development of cholestatic hepatitis, complicated by portal hypertension.
3. Fresh cut, dried bark may cause vomiting and diarrhea.
4. It may allergic effect.
5. Etc.
References
(1) Emodin ameliorates lipopolysaccharide-induced mastitis in mice by inhibiting activation of NF-κB and MAPKs signal pathways by Li D, Zhang N, Cao Y, Zhang W, Su G, Sun Y, Liu Z, Li F, Liang D, Liu B, Guo M, Fu Y, Zhang X, Yang Z.(PubMed)
(2) Evaluation of therapeutic potential of nanosilver particles synthesised using aloin in experimental murine mastitis model by Chaitanya Kumar TV, Muralidhar Y, Prasad PE, Prasad TN, Alpha Raj M.(PubMed)
Mastitis is the inflammation of breast tissue, mostly caused by Staphylococcus aureus
The ingredients
Besides the main compound of anthraquinones, other compounds include anthraquinone glycosides, (emodin, frangulin, iso-emodin, aloe-emodin, and chrysophanol), rhein, aloin, malic acid, tannic acid, cascarosides A, B, C, and D, and hydroxy anthracene derivatives (HAD), etc.
The effects
Nanosilver particles (AAgNPs), a derivative of the chemical constituent of aloin found in Cascara Sagrada may be the potential target used as antibiotics for the treatment of infectious and inflammatory diseases, including mastitis. In the Staphylococcus aureus induced murine mastitis study of a total of 40 female mice were divided into five groups of eight animals each, Nanosilver particles (AAgNPs) is found to be effective (concentration of 21.8) than antibiotic as it exerted the anti-inflammatory activity in reducing white blood cell (poly-morpho nuclear cell) infiltration.Other chemical compound emodin found in the herb, in a study of the same but with lipopolysaccharide (LPS)-induced mastitis also found to significantly reduced infiltration of neutrophilic granulocyte. These results may be given the green light for the chemical compounds of Cascara Sagrada used as a novel treatment strategy for mastitis.
The Side effects
1. Cascara Sagrada can be liver toxic.
2. It may cause Postal hypertension
Cascara sagrada (CS) has been associated with the development of cholestatic hepatitis, complicated by portal hypertension.
3. Fresh cut, dried bark may cause vomiting and diarrhea.
4. It may allergic effect.
5. Etc.
References
(1) Emodin ameliorates lipopolysaccharide-induced mastitis in mice by inhibiting activation of NF-κB and MAPKs signal pathways by Li D, Zhang N, Cao Y, Zhang W, Su G, Sun Y, Liu Z, Li F, Liang D, Liu B, Guo M, Fu Y, Zhang X, Yang Z.(PubMed)
(2) Evaluation of therapeutic potential of nanosilver particles synthesised using aloin in experimental murine mastitis model by Chaitanya Kumar TV, Muralidhar Y, Prasad PE, Prasad TN, Alpha Raj M.(PubMed)
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