Scientists from the respectable institution may have found an ingredient from herbal chamomile for the treatment of Gastric ulcers with little or no side effects.
According to the King Khalid University, in ethanol-induced Gastric ulcers, Chamomilla Recutita (ACE), exhibited the expression of the antioxidant glutathione in regulation of the herbal mediated effect on the gastric ulcer.
Dr. Al-Hashem FH, the author of the study, said," Compared to non-ACE treated rats, the ulcer index (UI) decreased significantly in a dose-dependent manner in treated animals" and " glutathione(GSH) levels fell significantly after ethanol treatment; this decrease was prevented by ACE treatment".
Gastric ulcer, a type of peptic ulcer is a condition of localized tissue erosion in the lining the stomach, inducing symptoms of abdominal pain, bloating, septic shock, Dyspepsia, Blood in stool, bleeding, etc.
Chamomile is also known as camomile, the common name of many species daisy-like plants in the family Asteraceae, used in traditional medicine as antispasmodic and anti-inflammatory constituents and to treat menstrual cramps and sleep disorders, reduce cramping and spastic pain in the bowels, relieve excessive gas and bloating in the intestine, etc.
The herbal medicine Alpha-bisabolol, a bioactive component, in the animal study also inhibited gastric mucosal damage. Oral doses of 50 and 100 mg=kg markedly attenuated the gastric lesions induced by ethanol to the extent of 87% and 96% in the activation of cellular metabolism.
Furthermore, the commercial preparation (STW 5, Iberogast), containing the extracts of bitter candy tuft, lemon balm leaf, chamomile flower, caraway fruit, peppermint leaf, licorice root, Angelica root, milk thistle fruit and greater celandine herb, tested in patients with gastric ulcer, not only lower the gastric acidity but also inhibited the secondary hyperacidity.
In ethanol-induced acute gastric mucosal injury in rats, Matricaria chamomilla L. (Compositae) hydroalcoholic extract (MCE) exerted a protective effect against ethanol-induced gastric mucosal lesions, depending upon the reduction in lipid peroxidation and augmentation in antioxidant activity. Dr. Cemek M, the lead researcher at the Afyon Kocatepe University suggested.
There is no doubt that chamomile and combination of chamomile with other herbal medicines are found to express gastrointestinal effects in reduced risk and treatment of gastric ulcers. But effective doses should only be prescribed by herbalists to prevent toxicity.
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Sources
(1) Gastroprotective effects of aqueous extract of Chamomilla recutita against ethanol-induced gastric ulcers by Al-Hashem FH1.(PubMed)
(2) Bisabolol-induced gastroprotection against acute gastric lesions: role of prostaglandins, nitric oxide, and KATP+ channels by Bezerra SB1, Leal LK, Nogueira NA, Campos AR.(PubMed)
(3) Mechanisms involved in the gastro-protective effect of STW 5 (Iberogast) and its components against ulcers and rebound acidity by Khayyal MT1, Seif-El-Nasr M, El-Ghazaly MA, Okpanyi SN, Kelber O, Weiser D.(PubMed)
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