The prevalence of breast cancer has been acknowledged in the scientific community worldwide.
Breast cancer widespread in women in Southeast Asian as a result of over 2 decades of economic prosperity caused by unhealthy diet is a major concern.
The findings for effective treatments are ongoing with some successes, but to discover an effective prevention and treatment with little or no side effects has proven difficult.
According to statistic, the risk of getting invasive breast cancer during the lifetime of women is 1/8.
A healthy diet with plenty vegetables and fruits(1)(2)(3) with a change of lifestyle(4)(5)(6) may be the only choice for women in reducing the risk of the diseases.
1. Blueberry
Blueberry is a flowering plant, belongings to the family Eriaceae, native to Northern America.
Triple-negative breast cancer TNBC, cancer does not express the genes for estrogen receptor (ER), progesterone receptor(PR), and HER2(gene) affecting approximately 15% of all cancer cases.
Female MDA-MB-231 tumor-bearing mice fed with a high-fat diet with 5% whole blueberry powder (BB), inhibited TNBC and TNBC-related metastasis by reducing inflammation via specific cytokine-driven pathways through the immune response in reduced tumor growth and metastasis(40).
In 17β-estradiol-mediated mammary tumorigenesis, 5% blueberry diet, decreased tumor volume and multiplicity significantly, by down-regulation of CYP 1A1(enzymes, able to activate compounds with carcinogenic properties) and ER-α (a receptor activated by the sex hormone estrogen)genes expression and also favorable modulation of microRNA (mir-18a and mir-34c) levels in gene regulation(41).
Other chemical constituents such as anthocyanin and anthocyanin-pyruvic acid adduct extract of blueberry restricted cancer cell proliferation by acting as cell anti invasive factors and chemoinhibitors(42).
2. Avocado
Avocados, the green-skinned, pear-shaped fruit that ripens after harvesting are a commercially valuable fruit cultivated in tropical climates throughout the world, native to the Caribbean, Mexico, South America, and Central America, belongings to the flowering plant family Lauraceous.
Avocado-produced toxin persin may contain a positive anti-breast cancer effect(43).
Persin exerted a significant anti-breast cancer effect in both estrogen receptor (ER) and ER-negative breast cancer cells(45).
Application of persin in animal model, selectively induced G2-M cell cycle arrest and cell death through the caspase-dependent pathway(44).
3. Strawberry
Strawberries are a genius of Fragaria × ananassa belongings to the family Roseaceae, grown all over the world with suitable climate for commercial profits and for health benefits.
Methanolic extract of strawberry (MESB) fruits induced cytotoxicity in cancer cells, irrespective of origin, in a concentration- and time-dependent manner, in the testing against leukaemia (CEM) and breast cancer (T47D) cell lines through induction of intrinsic pathway of apoptosis by activating p73 (a tumor suppressor) in breast cancer cells, when tumor suppressor gene p53 was mutated(46).
Polyphenols, a major chemical component found in strawberry, exhibited cytotoxic with doses of approximately 50 microg/ml, inducing 50% reduction in cell survival in both the normal and the tumor lines, including (MCF-7) breast cancer cell lines(47).
In another study, freeze-dried fruits of two strawberry cultivars ethanol extract strongly inhibited CaSki and SiHa cervical cancer cell lines and MCF-7 and T47-D breast cancer cell lines(48).
4. Pomegranate
Pomegranate is a fruit-bearing small tree, genus Punica, belongings to family Lythraceae, native to Iran, cultivated in Asian since ancient time.
Pomegranate extracts and genistein exerted anti-cancer effect in inhibition of cell proliferation and induction of apoptosis in human breast cancer cells(MCF-7) in doses and time depending manner(49) by downregulated HR genes (a ubiquitous cellular pathway that mediates transfer of genetic information) and increased expression of microRNAs (miRNAs), miR-183 (predicted target RAD50) and miR-24 (regulation of gene expression)(50).
Pomegranate fruit extracts (PFEs), on dose-dependent, inhibited NF-kB-dependent reporter gene responses associated with proliferation, invasion, and motility in aggressive breast cancer phenotypes while decreasing RhoC and RhoA protein expression as these genes are associated with tumor cell invasion and metastasis(51).
6. Grapes
Resveratrol, a polyphenolic compound known as a good chemopreventive agent for inhibiting carcinogenesis processes that target the regulators of cell function and DNA replication, found abundantly in grapes, berries and peanuts are associated to reduced risk of breast cancer.
HS-1793, a synthetic version of the compound of resveratrol-induced G2/M(DNA damage checkpoint) arrest in the cell cycle progression through induction of p53(tumor suppressor gene)-dependent apoptosis in MCF-7 cells(52).
Catechin (RQC), a polyphenol, was effective in ameliorated mammary tumor growth and metastasis, by reduced Akt (multiple cellular process activity, induced the activation of AMPK(cellular energy)), and inhibited mTOR(mediate cellular responses) signaling in breast cancer cells(53).
In Her-2 breast cancer, fox grape seed extract increased the expression of Bax(an apoptosis promoter) and AIF(Apoptosis-inducing factor), and decreased total PARP(cellular processes) expression, leading to significant downregulation of Her-2 in MCF-7 cells(54).
7. Pineapple
Pineapple is a species of Ananas Comos, belongings to the family Bromeliaceae and native to southern Brazil and Paraguay, cultivated for commercial uses.
Pineapple rich of vitamins and mineral and digesting enzyme bromelin seems to help digestion after a high protein meal.
Persin exerted a significant anti-breast cancer effect in both estrogen receptor (ER) and ER-negative breast cancer cells(45).
Bromelain, a major chemical constituent exerted anti-metastasis against breast cancer by upregulating the function of c-Jun N-terminal kinase in cell proliferation, differentiation, survival and migration, and p38 kinase to cause programmed cell death(56).
In GI-101A breast cancer cells, bromelain induced cell death via activation of the apoptosis mechanism, in increased dose-dependent by promoting apoptosis and cytokine processing of caspase-9 and caspase-3 coinciding with the elevation of serum CK18 levels(56).
In the brMDA-MB-231 mammary carcinoma, oral administration of bromelain increased the reduced bMAK- and MAK-cell activity in cell cycle regulation from 7.8% to 54% (bMAK-cell activity) and from 16% to 47% (MAK-cell activity by stimulating the deficient monocytic cellular cytotoxicity of the mammary tumor(57).
8. Apple
Apple is the pomaceous fruit of the apple tree, a species of the rose family Rosaceae, originated in Central Asia.
In estrogen-dependent MCF-7 and estrogen-independent MDA-MB-231 breast cancer cell lines, apple phytochemical extracts significantly inhibited cell proliferation in a dose-dependent manner and cell cycle modulation(58).
In breast carcinoma, Mcf-7 and Mcf-7, Her18 cells, peels of apple were effective in antiproliferation accompanied by a G0-G1 phase arrest in cell cycle through activated tumor suppressor protein that suppressed the regulation of cell invasion, metastasis, and angiogenesis(59).
Study of apple extracts and quercetin 3-beta-d-glucoside combination also showed to possess the synergistic effect in MCF-7 cell proliferation(60).
9. Orange
Orange is a species of Citrus Sinensis, belongings to the family Rutaceae and native to Southeast Asia.
Polymethoxyflavones (PMFs), a chemical compound found in sweet orange (Citrus sinensis L.) peel, induced Ca(2+)-mediated apoptosis in human breast cancer cells through proapoptotic activity(61).
D-limonene, another compound in orange peel oil, in rodent studies, also exhibited chemotherapeutic activity against mammary cells, through the induction of tumor cell apoptosis, tumor redifferentiation, and/or suppression of key proteins of cell growth-regulating (62).
Taken Together, vegetables(7)(8) and fruits(9)(10) or their chemical compounds may process a huge effect in reduced risk, progression and treatment of the breast cancer through induced apoptosis by blocking the energy sources of the pathways, influencing the signal pathways of cell proliferation or suppressing the promoted cancers genes.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
1) Intake of specific fruits and vegetables in relation to risk of estrogen receptor-negative breast cancer among postmenopausal women by Fung TT, Chiuve SE, Willett WC, Hankinson SE, Hu FB, Holmes MD. (PubMed)
(2) Fruits, vegetables, and breast cancer risk: a systematic review and meta-analysis of prospective studies by Aune D, Chan DS, Vieira AR, Rosenblatt DA, Vieira R, Greenwood DC, Norat T.(PubMed)
(3) Premenopausal breast cancer risk and intake of vegetables, fruits, and related nutrients.
Freudenheim JL, Marshall JR, Vena JE, Laughlin R, Brasure JR, Swanson MK, Nemoto T, Graham S.(PubMed)(4) Lifestyle and risk of development of breast and ovarian cancer by Pięta B, Chmaj-Wierzchowska K, Opala T.(PubMed)
(5) Epidemiological evidence for a relationship between life events, coping style, and personality factors in the development of breast cancer by Butow PN, Hiller JE, Price MA, Thackway SV, Kricker A, Tennant CC.(PubMed)
(6) Epidemiological correlates of breast cancer in South India by Babu GR, Lakshmi SB, Thiyagarajan JA.(PubMed)
(7) Dietary organic isothiocyanates are cytotoxic in human breast cancerMCF-7 and mammary epithelial MCF-12A cell lines by Tseng E, Scott-Ramsay EA, Morris ME.(PubMed)
(8) Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype by
(9) Extracts of strawberry fruits induce intrinsic pathway of apoptosis in breast cancer cells and inhibits tumor progression in mice.by Somasagara RR, Hegde M, Chiruvella KK, Musini A, Choudhary B, Raghavan SC.(PubMed)
(10) Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro.by Seeram NP, Adams LS, Zhang Y, Lee R, Sand D, Scheuller HS, Heber D.(PubMed)(43) Synthesis and in vitro evaluation of analogues of avocado-produced toxin (+)-(R)-persin in human breast cancer cells by Brooke DG, Shelley EJ, Roberts CG, Denny WA, Sutherland RL, Butt AJ.(PubMed)
(44) A novel plant toxin, persin, within vivo activity in the mammary gland, induces Bim-dependent apoptosis in human breast cancer cells by Butt AJ, Roberts CG, Seawright AA, Oelrichs PB, Macleod JK, Liaw TY, Kavallaris M, Somers-Edgar TJ, Lehrbach GM, Watts CK, Sutherland RL.(PubMed)
(45) Synergistic cytotoxicity between tamoxifen and the plant toxin persin in human breast cancer cells is dependent on Bim expression and mediated by modulation of ceramide metabolism by Roberts CG, Gurisik E, Biden TJ, Sutherland RL, Butt AJ.(PubMed)
(46) Extracts of strawberry fruits induce intrinsic pathway of apoptosis in breast cancer cells and inhibits tumor progression in mice by Somasagara RR, Hegde M, Chiruvella KK, Musini A, Choudhary B, Raghavan SC.(PubMed)
(47) Strawberry polyphenols are equally cytotoxic to tumourigenic and normal human breast and prostate cell lines by Weaver J, Briscoe T, Hou M, Goodman C, Kata S, Ross H, McDougall G, Stewart D, Riches A.(PubMed) (48) Anticarcinogenic Activity of Strawberry, Blueberry, and Raspberry Extracts to Breast and Cervical Cancer Cells, by Wedge DE, Meepagala KM, Magee JB, Smith SH, Huang G, Larcom LL.(PubMed)
(49) Anticancer activities of pomegranate extracts and genistein in human breast cancer cells by Jeune MA, Kumi-Diaka J, Brown J.(PubMed)
(50) Antiproliferative effects of pomegranate extract in MCF-7 breast cancer cells are associated with reduced DNA repair gene expression and induction of double-strand breaks by Shirode AB, Kovvuru P, Chittur SV, Henning SM, Heber D, Reliene R.(PubMed)
(51) Pomegranate fruit extract impairs invasion and motility in human breast cancer by Khan GN, Gorin MA, Rosenthal D, Pan Q, Bao LW, Wu ZF, Newman RA, Pawlus AD, Yang P, Lansky EP, Merajver SD.(PubMed)
(52) The effect of grapefruit intake on endogenous serum estrogen levels in postmenopausal women by Monroe KR, Stanczyk FZ, Besinque KH, Pike MC.(PubMed)
(53) HS-1793, a resveratrol analogue, induces cell cycle arrest and apoptotic cell death in human breast cancer cells by Kim JA, Kim DH, Hossain MA, Kim MY, Sung B, Yoon JH, Suh H, Jeong TC, Chung HY, Kim ND.(PubMed)
(54) Grape polyphenols inhibit Akt/mammalian target of rapamycin signaling and potentiate the effects of gefitinib in breast cancer by Castillo-Pichardo L, Dharmawardhane SF.(PubMed)
(55) Suppression of oncoprotein Her-2 and DNA damage after treatment with Flavan-3- of Vitis labrusca extract by Scola G, Fernandes Correia Laurino CC, Menin E, Salvador M.(PubMed)
(56) Bromelain-induced apoptosis in GI-101A breast cancer cells by Dhandayuthapani S, Perez HD, Paroulek A, Chinnakkannu P, Kandalam U, Jaffe M, Rathinavelu A.(PubMed)
(57) Effects of oral bromelain administration on the impaired immunocytotoxicity of mononuclear cells from mammary tumor patients by Eckert K, Grabowska E, Stange R, Schneider U, Eschmann K, Maurer HR.(PubMed)
(58) Apple phytochemical extracts inhibit proliferation of estrogen-dependent and estrogen-independent human breast cancer cells through cell cycle modulation by Sun J, Liu RH.(PubMed)
(59) Antiproliferative effects of apple peel extract against cancer cells by Reagan-Shaw S, Eggert D, Mukhtar H, Ahmad N.(PubMed)
(60) Synergistic effect of apple extracts and quercetin 3-beta-d-glucoside combination on antiproliferative activity in MCF-7 human breast cancercells in vitro by Yang J, Liu RH.(PubMed)
(61) Apoptosis-inducing activity of hydroxylated polymethoxyflavones and polymethoxyflavones from orange peel in human breast cancer cells by Sergeev IN, Ho CT, Li S, Colby J, Dushenkov S.(PubMed)
(62) Monoterpenes in breast cancer chemoprevention by Crowell PL.(PubMed)
Sunday, October 7, 2018
How to Prevent Over Expression of Melanin Inducing Age Spots Naturally
Green tea may have a therapeutic and positive effect in reducing age spots caused by overexpression of melanin, some scientists suggested.
People with a light complexion and lots of sun exposure over the years are found to associate with higher prevalent risk.
The results of this investigation were carried out by some worldwide institutes, including the Chongqing Institute of Forensic Science.
You can view the publication through some online medical literature if you want to know more of these subjects.
Age spot is the overexpression of skin pigment in the surface of the skin, probably caused by Skin aging, sun exposure, or other forms of ultraviolet (UV) light exposure,...
Age spots may also be caused by the hormones imbalance in the induction of increased production of melanin, which is responsible for darkening the skin.
Green tea is a precious drink processed numbers of health benefit and known to almost everyone in Asia and the Western world.
In the investigation of Epigallocatechin gallate (EGCG), used as a constituent of cosmetic products, researchers found that application of EGCG exerts a significant effect as an antioxidant in exhibited anti-pigmentation properties.
Through measuring hyaluronic acid synthase (HAS) and hyaluronidase (HYAL) gene expression, EGCG also promoted skin hydration, through increased the expression of a natural moisturizing factor-related gene, including Hyaluronan synthase (HAS)-1, and (HAS)-2.
HA synthase enzymes (HAS) are molecules with the function of synthesized hyaluronan (HA) plays an essential role in protected skin fibroblasts against apoptosis, due to environmental stress exposure.
Hyaluronidase ((HYAL) is an enzyme that cleaves HA.
In UVB irradiation conditions, application of EGCG protected the expression of the decreased level of HYAL found in all tissues with 50% present in skin, thus reducing HaCaT cells in the formation of free radicals and decreased in cell viability.
Melanin produced in melanocytes, underexposure UVB irradiation with an aim to protect skin cells against UVB radiation damage.
Years of frequent and prolonged sun exposure and overexpression of melanin may induce aging spot
In other words, EGCG not only exhibited a strong effect in reduced over secretion of melanin but also enhanced cells integrity against forming of aging spots due to exposure UVB irradiation
HaCaT widely used in scientific research of epidermis, is a spontaneously immortalized human keratinocyte cell line isolated from adult human skin.
Dr. Kim E, the lead authors said, "EGCG might be used as a cosmetic ingredient with positive effects on skin hydration, moisture retention, and wrinkle formation, in addition to radical scavenging activity and reduction of melanin generation".
Furthermore, in confirmation of green tea efficacy in reduced overexpression of skin pigment by evaluating the fatty acids contents in the green tea oil, researchers indicated that all 3 major fatty acids isolated from oil were oleic acid (87.93±0.19%), stearic (5.14±0.06%) and palmitic (5.08±0.12%) acids.
A single application of each fatty acid demonstrated a strong protection of the cell viabilities through their antioxidant activity.
Moreover, the antioxidant activity of 3% tea seed oil exerted a greater cellular protection with cell viability of 90.38±7.77% in compared to other concentrations.
Some researchers suggested that green tea polyphenols and theophylline as polyphenol nanoparticles (PNs) may reduce skin aging through nanoparticle formation process involved copolymerization of monomers through exhibiting its free radicals scavenging activities.
Taking all together, green tea and its bioactive compound such as EGCG may be used as natural and functional food for reduced overexpression of melanin and skin pigment in the induction of age spots.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299
Sources
(1) Skin Protective Effect of Epigallocatechin Gallate by Kim E1, Hwang K2, Lee J3, Han SY4, Kim EM5, Park J6, Cho JY7.(PubMed)
(2) Green Tea Makes Polyphenol Nanoparticles with Radical-Scavenging Activities by Xiang S1, Yang P1, Guo H2, Zhang S1, Zhang X1, Zhu F1, Li Y1. (PubMed)
(3) Melanogenesis Inhibitory and Antioxidant Effects of Camellia oleifera Seed Oil by Chaikul P1,2, Sripisut T1,2, Chanpirom S1,2, Sathirachawan K1, Ditthawuthikul N1,2.(PubMed)
People with a light complexion and lots of sun exposure over the years are found to associate with higher prevalent risk.
The results of this investigation were carried out by some worldwide institutes, including the Chongqing Institute of Forensic Science.
You can view the publication through some online medical literature if you want to know more of these subjects.
Age spot is the overexpression of skin pigment in the surface of the skin, probably caused by Skin aging, sun exposure, or other forms of ultraviolet (UV) light exposure,...
Age spots may also be caused by the hormones imbalance in the induction of increased production of melanin, which is responsible for darkening the skin.
Green tea is a precious drink processed numbers of health benefit and known to almost everyone in Asia and the Western world.
In the investigation of Epigallocatechin gallate (EGCG), used as a constituent of cosmetic products, researchers found that application of EGCG exerts a significant effect as an antioxidant in exhibited anti-pigmentation properties.
Through measuring hyaluronic acid synthase (HAS) and hyaluronidase (HYAL) gene expression, EGCG also promoted skin hydration, through increased the expression of a natural moisturizing factor-related gene, including Hyaluronan synthase (HAS)-1, and (HAS)-2.
HA synthase enzymes (HAS) are molecules with the function of synthesized hyaluronan (HA) plays an essential role in protected skin fibroblasts against apoptosis, due to environmental stress exposure.
Hyaluronidase ((HYAL) is an enzyme that cleaves HA.
In UVB irradiation conditions, application of EGCG protected the expression of the decreased level of HYAL found in all tissues with 50% present in skin, thus reducing HaCaT cells in the formation of free radicals and decreased in cell viability.
Melanin produced in melanocytes, underexposure UVB irradiation with an aim to protect skin cells against UVB radiation damage.
Years of frequent and prolonged sun exposure and overexpression of melanin may induce aging spot
In other words, EGCG not only exhibited a strong effect in reduced over secretion of melanin but also enhanced cells integrity against forming of aging spots due to exposure UVB irradiation
HaCaT widely used in scientific research of epidermis, is a spontaneously immortalized human keratinocyte cell line isolated from adult human skin.
Dr. Kim E, the lead authors said, "EGCG might be used as a cosmetic ingredient with positive effects on skin hydration, moisture retention, and wrinkle formation, in addition to radical scavenging activity and reduction of melanin generation".
Furthermore, in confirmation of green tea efficacy in reduced overexpression of skin pigment by evaluating the fatty acids contents in the green tea oil, researchers indicated that all 3 major fatty acids isolated from oil were oleic acid (87.93±0.19%), stearic (5.14±0.06%) and palmitic (5.08±0.12%) acids.
A single application of each fatty acid demonstrated a strong protection of the cell viabilities through their antioxidant activity.
Moreover, the antioxidant activity of 3% tea seed oil exerted a greater cellular protection with cell viability of 90.38±7.77% in compared to other concentrations.
Some researchers suggested that green tea polyphenols and theophylline as polyphenol nanoparticles (PNs) may reduce skin aging through nanoparticle formation process involved copolymerization of monomers through exhibiting its free radicals scavenging activities.
Taking all together, green tea and its bioactive compound such as EGCG may be used as natural and functional food for reduced overexpression of melanin and skin pigment in the induction of age spots.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299
Sources
(1) Skin Protective Effect of Epigallocatechin Gallate by Kim E1, Hwang K2, Lee J3, Han SY4, Kim EM5, Park J6, Cho JY7.(PubMed)
(2) Green Tea Makes Polyphenol Nanoparticles with Radical-Scavenging Activities by Xiang S1, Yang P1, Guo H2, Zhang S1, Zhang X1, Zhu F1, Li Y1. (PubMed)
(3) Melanogenesis Inhibitory and Antioxidant Effects of Camellia oleifera Seed Oil by Chaikul P1,2, Sripisut T1,2, Chanpirom S1,2, Sathirachawan K1, Ditthawuthikul N1,2.(PubMed)
Saturday, October 6, 2018
How to Protect Yourself From Allergies Naturally
Including a portion of fennel in your daily diet may improve the body anti-allergic activities, some scientists suggested.
The results of the differentiation were carried out by numbers of universities and published on online medical literature.
Allergic effect associated with nonharmful allergens caused by an overreaction of the immune system may induce symptoms of skin rash, sneezing,....
In some cases, an allergic reaction can be life-threatening (anaphylaxis), depending on the severity of immune responses.
Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
19. Etc.
In the study to confirm the potential efficacy of fennel for antiallergic use, inhibitory actions of the fruiton 5-lipoxgenase (5-LOX) and β-hexosaminidase release, researchers found that application of fennel extract at ethanol 70% with IC50 of 3.2 μg/ml, exerts a potential effect in inhibited 5-LOX-catalyzed leukotriene production in mediation of allergy, and other immune responses.
β-hexosaminidase released from activated mast cells are responsible for the allergic inflammatory reactions associated with immune response.
5-Lipoxygenase (5-LOX), an enzyme plays important roles in infection and allergic responses.
Although many ingredients isolated from fennel fruit demonstrated an inhibitory effect in the reduced immune overreaction of the unharmful allergens, phenylpropanoid, trans-anethole, showed the considerable inhibitory action of 5-LOX in compared to others, particularly at IC50 of 51.6 μM of trans-anethole
However, the fennel bioactive compound trans-anethole displayed insignificant effect on the degranulation reaction of β-hexosaminidase release from antigen-treated RBL-2H3 cells in compared to other ingredients.
RBL-2H3 cell line is a commonly used histamine-releasing cell line in immunological research of. inflammatory and allergic activities.
These results suggested, depending on the stimulation of allergens, fennel demonstrated anti-allergic activity through expression of different constituents in both the plant (FR) and trans-anethole alone.
Dr. the lead author after taking into account of other co-founders, said, "FR and several major constituents are 5-LOX inhibitors and they may have the potential for treating 5-LOX-related disorders".
Additionally, according to the study of Yonsei University, oral administration (200 mg/kg) of Foeniculum vulgare fruit methanolic extract in tested animal model exhibited inhibitory effects against acute and subacute inflammatory diseases and type IV allergic reactions, a delayed type hypersensitivity usually takes a few days to develop.
Further analysis suggested that application of fennel also reduced inflammatory factors activated by
the immune response in the induction of systemic inflammation against allergens in causing damage to the body through its antioxidants and stimulated productions of antioxidant enzymes from the host, such as superoxide dismutase (SOD) and catalase and the high-density lipoprotein-cholesterol level.in the prevention of lipid peroxidation in initiated by ROS.
Moreover, the application also reduced levels of malondialdehyde (MDA), which is an indication and maker of oxidative stress.
Interestingly, F. vulgare fruit methanolic extract expressed a strong effect in inhibition of nitric oxide (NO) produced by the innate immune system through activated macrophages in inhibited pathogens replication.
The above differentiation was supported by the literature of "Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology"
posted in the BioMed Research International.
According to the study, oral injection of the methanolic extract of F. vulgare fruit at200 mg/kg once a day for 7 days showed a significant inhibitory effect on DNFB- (2,4-dinitrofluorobenzene-) induced delayed type hypersensitivity through fennel immunosuppressive properties.
2,4-dinitrofluorobenzene (DNFB) may induce allergic contact dermatitis.
The information collected indicated that fennel, its bioactive compounds, and extracts may be considered as a functional food for reduced risk immune over the response to unharmful allergens.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299
Sources
(1) 5-Lipoxygenase Inhibition of the Fructus of Foeniculum vulgare and Its Constituents by Lee JH1, Lee DU, Kim YS, Kim HP. (PubMed)
(2) Antiinflammatory, analgesic and antioxidant activities of the fruit of Foeniculum vulgare by Choi EM1, Hwang JK. (PubMed)
(3) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)
The results of the differentiation were carried out by numbers of universities and published on online medical literature.
Allergic effect associated with nonharmful allergens caused by an overreaction of the immune system may induce symptoms of skin rash, sneezing,....
In some cases, an allergic reaction can be life-threatening (anaphylaxis), depending on the severity of immune responses.
Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,...
Nutrients
1. Carbohydrates
2. Fiber
3. Protein
4. Thiamine (Vitamin B1)
5. Riboflavin (Vitamin B2)
6. Niacin (Vitamin B3)
7. Pantothenic acid (B5)
8. Vitamin B6
9. Folate (Vitamin B9)
10. Vitamin C
11. Calcium
12. Copper
13. Iron
14. Magnesium
15. Molybdenum
16. Phosphorus
17. Potassium
18. Zinc
19. Etc.
In the study to confirm the potential efficacy of fennel for antiallergic use, inhibitory actions of the fruiton 5-lipoxgenase (5-LOX) and β-hexosaminidase release, researchers found that application of fennel extract at ethanol 70% with IC50 of 3.2 μg/ml, exerts a potential effect in inhibited 5-LOX-catalyzed leukotriene production in mediation of allergy, and other immune responses.
β-hexosaminidase released from activated mast cells are responsible for the allergic inflammatory reactions associated with immune response.
5-Lipoxygenase (5-LOX), an enzyme plays important roles in infection and allergic responses.
Although many ingredients isolated from fennel fruit demonstrated an inhibitory effect in the reduced immune overreaction of the unharmful allergens, phenylpropanoid, trans-anethole, showed the considerable inhibitory action of 5-LOX in compared to others, particularly at IC50 of 51.6 μM of trans-anethole
However, the fennel bioactive compound trans-anethole displayed insignificant effect on the degranulation reaction of β-hexosaminidase release from antigen-treated RBL-2H3 cells in compared to other ingredients.
RBL-2H3 cell line is a commonly used histamine-releasing cell line in immunological research of. inflammatory and allergic activities.
These results suggested, depending on the stimulation of allergens, fennel demonstrated anti-allergic activity through expression of different constituents in both the plant (FR) and trans-anethole alone.
Dr. the lead author after taking into account of other co-founders, said, "FR and several major constituents are 5-LOX inhibitors and they may have the potential for treating 5-LOX-related disorders".
Additionally, according to the study of Yonsei University, oral administration (200 mg/kg) of Foeniculum vulgare fruit methanolic extract in tested animal model exhibited inhibitory effects against acute and subacute inflammatory diseases and type IV allergic reactions, a delayed type hypersensitivity usually takes a few days to develop.
Further analysis suggested that application of fennel also reduced inflammatory factors activated by
the immune response in the induction of systemic inflammation against allergens in causing damage to the body through its antioxidants and stimulated productions of antioxidant enzymes from the host, such as superoxide dismutase (SOD) and catalase and the high-density lipoprotein-cholesterol level.in the prevention of lipid peroxidation in initiated by ROS.
Moreover, the application also reduced levels of malondialdehyde (MDA), which is an indication and maker of oxidative stress.
Interestingly, F. vulgare fruit methanolic extract expressed a strong effect in inhibition of nitric oxide (NO) produced by the innate immune system through activated macrophages in inhibited pathogens replication.
The above differentiation was supported by the literature of "Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology"
posted in the BioMed Research International.
According to the study, oral injection of the methanolic extract of F. vulgare fruit at200 mg/kg once a day for 7 days showed a significant inhibitory effect on DNFB- (2,4-dinitrofluorobenzene-) induced delayed type hypersensitivity through fennel immunosuppressive properties.
2,4-dinitrofluorobenzene (DNFB) may induce allergic contact dermatitis.
The information collected indicated that fennel, its bioactive compounds, and extracts may be considered as a functional food for reduced risk immune over the response to unharmful allergens.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299
Sources
(1) 5-Lipoxygenase Inhibition of the Fructus of Foeniculum vulgare and Its Constituents by Lee JH1, Lee DU, Kim YS, Kim HP. (PubMed)
(2) Antiinflammatory, analgesic and antioxidant activities of the fruit of Foeniculum vulgare by Choi EM1, Hwang JK. (PubMed)
(3) Foeniculum vulgare Mill: A Review of Its Botany, Phytochemistry, Pharmacology, Contemporary Application, and Toxicology by Shamkant B. Badgujar,* Vainav V. Patel, and Atmaram H. Bandivdekar(PubMed)
Friday, October 5, 2018
Herbal Anise May Process A Cure of Nonalcoholic Fatty Liver Disease (NAFLD), MEDLINE Studies Show
Intake of herbal Anise together with the change of diet pattern may have a potential and substantial effect in the cure of nonalcoholic fatty liver disease (NAFLD).
The nonalcoholic fatty liver disease is a medical condition characterized by fat accumulated in the liver tissue other than excessive consumption of alcohol.
According to the American liver foundation, Nonalcoholic Fatty Liver Disease is one of the most common causes of liver disease and approximately 30% (100 million) individuals in the United States are estimated to have the nonalcoholic fatty liver disease.
The causes of Nonalcoholic Fatty Liver Disease are unknown. Also, as of today researchers do not understand why some people are susceptible to liver fat accumulation while others are not.
However, some researchers suggested that combined health problems such as overweight and obesity, insulin resistance, hyperglycemia, and hyperlipidemia may all contribute to the onset of the diseases.
Prolonged and untreated Nonalcoholic Fatty Liver Disease may induce complication of cirrhosis, a disease characterized by late-stage of fibrosis in the liver and untreated cirrhosis can lead to life-threatening diseases, such as a coma, liver failure, or death.
The Shahid Beheshti University of Medical Science in the examine the results of selected studies including in 33 full texts and 7 articles suggested that
*Intakes of red meat, fats, and sweets are associated with the elevated risk of NAFLD and consumption of whole grains, fruits and vegetables are associated with reduced risk of NAFLD.
* There is a highly positive association between the Western dietary pattern and the risk of NAFLD.
The university experiment also found that adherence to the Mediterranean diet was significantly associated with the attenuated severity of hepatic steatosis through improving insulin sensitivity in an insulin-resistant population with NAFLD,
Anise is a flowering plant of the species of Pimpinella anisum, genus Pimpinella, belongings to the family Apiaceae native to Egypt and the Mediterranean region, used in traditional herbal medicine as a fragrance in soaps, oils, and mouth fresheners and stomachic, antiseptic, anti-spasmodic,...
Chemical constituents
Anethole, D-pinene, I-phellandrene, Alpha-terpineol, Safrol, Methyl chavicol, Resin, Shikimic acid, etc.
In the comparison the effect of anise fruit essential oil and extract and risk of nonalcoholic fatty liver disease, the Islamic Azad University conducted an experiment of 60 rats randomly divided into ten groups, six in each group with NAFLD induced by using choline-deficient diet for 90 days and followed by 30 days of treatment with 25, 50, 100, and 200 mg/kg/day of hydroethanolic extract (AE) as well as 0.125, 0.25, and 0.5 mg/kg/day of essential oil (AO)
During the course and the end of the experiment, researchers showed that both applications exert significantly reverse activities in
* Increased plasma levels of total cholesterol, low-density lipoprotein, and triacylglycerol and
* Decreased high-density lipoprotein level caused by choline-deficient diet in a dose-dependent manner.
Additional differentiation also found that AE and AO reduced the elevated levels of enzymes aspartate transaminase (AST) and alanine transaminase (ALT) which are considered as indications of either liver injury or damage caused by the acute inflammation in the experiential subject model.
However, patients with the nonalcoholic fatty liver disease may have normal transaminase levels.
Levels of aspartate aminotransferase (AST) is usually used as a maker to detect liver damage.
Serum levels of alanine aminotransferase (ALT) are the best predictor of NAFLD after considering to other clinical and biochemical features.
Observation of injection of anise AE and AO also exerted a powerful antioxidant activity in significantly lower overexpression of ROS in the exhibited free radical chain reaction in the induction of oxidative stress to precipitate liver toxicity.
According to the St. Louis University Health Sciences Center, overexpression of free radicals in the liver can damage cellular macromolecules in the induction of hepatocellular injury.
Also, in histological findings, both AE and AO displayed a substantial effect in reduced macrovesicular steatohepatitis which is the leading cause of liver cancer.
Further analysis of the experiment, researchers found that both anise AE and AO demonstrated a strong effect in ameliorated lipid peroxidation induced by oxidative stress indicated by elevation of plasma level of 8-isoprostane which is correlated to the prevalence of non-alcoholic fatty liver disease (NAFLD).
Elevated 8-Isoprostane values activated by lipid peroxidation induced by injection of choline-deficient diet were also considered biomarker in patients with nonalcoholic liver disease and correlated to with body mass index and total cholesterol in NAFLD but did not significantly relate to sex, age, biochemical data or iron metabolism markers in all liver diseases.
Therefore, people with high body mass index and high levels of total cholesterol levels are susceptible to increased risk of the diseases.
Taken together, intake of herbal Anise with abundant of bioactive chemical constituents and change of diet pattern with rich of whole grains, fruits, and vegetables may have a higher potential in the cure of nonalcoholic liver disease,
However, further data collection on larger sample and multi-center clinical studies performed with human consumption during the course of the disease will be necessary to complete the picture of its anti nonalcoholic fatty liver disease (NAFLD) possibilities.
Intake of Anise extract should only be prescribed by related field specialist in the prevention of acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Pimpinella anisum L. fruit: Chemical composition and effect on rat model of nonalcoholic fatty liver disease by Asadollahpoor A1, Abdollahi M2, Rahimi R3,(PubMed)
(2) Relationship between Diet and Non-alcoholic Fatty Liver Disease: A Review Article by Mirmiran P1, Amirhamidi Z1, Ejtahed HS1, Bahadoran Z1, Azizi F2(PubMed)
Thursday, October 4, 2018
How to Treat Edema Naturally
Herbal Arnica may have a therapeutic and substantial effect in reducing progression and treatment of edema, some scientists suggested.
Arnica is a herbaceous species, genus perennial, belongings to the family Asteraceae, native to Europe and Asia, used in herbal medicine for centuries in the treatment of strains, sprains, and bruises.
Wound healing is a process of repairing after the damage of skin, tissues, organs, etc.
Edema is a condition, characterized by excessive accumulation of fluids in some tissues within the body.
Certain diseases including heart, liver, and kidneys may also increase the prevalence of edema as a result of salt retention in the induction of excess fluid accumulation.
Some researchers suggested that the alternation of starling forces which control the transfer of fluid from the vascular compartment to surrounding tissue spaces may be a culprit in facilitated edematous disorders.
However, in compared to diminished organs function in causes of edema, edematous states may share many of the same afferences and efferent mechanisms for sodium and water retention.
Long-term untreated edema may increase complications of painful swelling, difficulty walking. with skin becoming itchy and uncomfortable. In a serious case, it can cause infection in the swollen area and scarring between layers of tissue.
Some patients may also experience decreased blood circulation, the elasticity of arteries, veins, joints, and muscles in the surrounding infectious areas.
The ingredients
Helenalin, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivatives.
In the study to compare the efficacy of herbal Arnica and corticosteroids in reduced postoperative edema and bruising associated with rhinoplasty of 48 primary rhinoplasty patients randomly assigned to three groups as follow
* Group P received 10 mg of dexamethasone (intravenously) intraoperatively followed by a 6-day oral tapering dose of methylprednisone.
* Group A received Arnica three times a day for 4 days, and
* Group C received neither agent and served as the control.
3 blinded panelists were assigned to rate the extent of ecchymosis, including the intensity of the ecchymosis, and the severity of the edema
After observation of the study over the entire period, scientists found that
* There were no significant differences in all groups on the day 2 of postoperative
* In compared to increased swelling of the control group, both group A and P demonstrated a significant improvement in edema rating.
Interestingly, conventional medicine administration group exerted higher intensity of ecchymosis compared to groups A and C on the day of postoperative and all groups displayed no difference of magnitude of edema.
However, between the period of day 2 and 8, groups A and C exhibited significantly more resolution of ecchymosis in compared to group P.
The results suggested that although Arnica may have a therapeutic property in reducing edema during the early postoperative period. And the herbal medicine did not provide similar benefits in regard to the extent and intensity of ecchymosis in compared to corticosteroids.
In order to further confirmation of the effect of herbal Arnica in reduced postoperative ecchymosis and edema, researchers at the joint study lead University of Miami Miller School of Medicine, conducted an investigation in a select population of healthy volunteers after oculofacial surgery by examining the postoperative course and medical records of a total of 27 patients (16 females, 11 males) with age range from18 to 70 years using topical Arnica and Ledum after undergoing common oculofacial procedures, including blepharoplasty, browpexy, and rhinoplasty, in the hands of 4 surgeons at tertiary referral centers from July 1, 2012 to December 31, 2012.
According to the result of the experiment, application of Arnica 50 M (10) 50% and Ledum 50 M (10) pads bilaterally after surgery through postoperative day 6, showed a significantly accelerated healing from day 7 to day 12 in dose depending manner, without inflicting any adverse effects.
The findings suggested that application of composited Arnica and Ledum displays a potential efficacy in reducing postoperative ecchymosis and edema after oculofacial surgery.
The above differentiation of herbal Arnica in improved edema after surgery was supported by the joint study led by the Research Center of University of adult male Wistar rats inoculated with 1% carrageenan into the footpad to induce edema then treated with Arnica montana 6cH, dexamethasone (4.0 mg/kg; positive control) or 5% hydroalcoholic solution (negative control), per os, each 15 minutes, between 30 and 180 minutes after the irritant inoculation.
According to the investigation, application of Arnica group exhibited anti-edema through increased lymphatic edema absorption, particularly, in late edema and less intense edema treatment group after adjusting to the individually qualitative of inflammatory vascular events.
Moreover, the edema inhibition of Arnica was attributed to significantly reduced mast cell degranulation and increased lymphatic vessels diameter and decreased the production of prostaglandins associated to the development of edema, caused by subcutaneous carrageenan injection in the induction of local inflammation.
Taken together, herbal Arnica may be considered as a functional food in reduced risk, progression and for treatment of edema and ecchymosis.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A randomized, controlled comparison between arnica and steroids in the management of postrhinoplasty ecchymosis and edema by Totonchi A1, Guyuron B.(PubMed)
(2) Assessing the Effectiveness of Arnica montana and Rhododendron tomentosum (Ledum palustre) in the Reduction of Ecchymosis and Edema After Oculofacial Surgery: Preliminary Results by Kang JY1, Tran KD, Seiff SR, Mack WP, Lee WW. (PubMed)
(3) Inflammatory Process Modulation by Homeopathic Arnica montana 6CH: The Role of Individual Variation Ana Paula Kawakami,1 Cesar Sato,1 Thayna Neves Cardoso,1 and Leoni Villano Bonamin(Hindawi)
(4) Pathogenesis of sodium and water retention in edematous disorders by Paller MS, Schrier RW(PubMed)
Arnica is a herbaceous species, genus perennial, belongings to the family Asteraceae, native to Europe and Asia, used in herbal medicine for centuries in the treatment of strains, sprains, and bruises.
Wound healing is a process of repairing after the damage of skin, tissues, organs, etc.
Edema is a condition, characterized by excessive accumulation of fluids in some tissues within the body.
Certain diseases including heart, liver, and kidneys may also increase the prevalence of edema as a result of salt retention in the induction of excess fluid accumulation.
Some researchers suggested that the alternation of starling forces which control the transfer of fluid from the vascular compartment to surrounding tissue spaces may be a culprit in facilitated edematous disorders.
However, in compared to diminished organs function in causes of edema, edematous states may share many of the same afferences and efferent mechanisms for sodium and water retention.
Long-term untreated edema may increase complications of painful swelling, difficulty walking. with skin becoming itchy and uncomfortable. In a serious case, it can cause infection in the swollen area and scarring between layers of tissue.
Some patients may also experience decreased blood circulation, the elasticity of arteries, veins, joints, and muscles in the surrounding infectious areas.
The ingredients
Helenalin, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivatives.
In the study to compare the efficacy of herbal Arnica and corticosteroids in reduced postoperative edema and bruising associated with rhinoplasty of 48 primary rhinoplasty patients randomly assigned to three groups as follow
* Group P received 10 mg of dexamethasone (intravenously) intraoperatively followed by a 6-day oral tapering dose of methylprednisone.
* Group A received Arnica three times a day for 4 days, and
* Group C received neither agent and served as the control.
3 blinded panelists were assigned to rate the extent of ecchymosis, including the intensity of the ecchymosis, and the severity of the edema
After observation of the study over the entire period, scientists found that
* There were no significant differences in all groups on the day 2 of postoperative
* In compared to increased swelling of the control group, both group A and P demonstrated a significant improvement in edema rating.
Interestingly, conventional medicine administration group exerted higher intensity of ecchymosis compared to groups A and C on the day of postoperative and all groups displayed no difference of magnitude of edema.
However, between the period of day 2 and 8, groups A and C exhibited significantly more resolution of ecchymosis in compared to group P.
The results suggested that although Arnica may have a therapeutic property in reducing edema during the early postoperative period. And the herbal medicine did not provide similar benefits in regard to the extent and intensity of ecchymosis in compared to corticosteroids.
In order to further confirmation of the effect of herbal Arnica in reduced postoperative ecchymosis and edema, researchers at the joint study lead University of Miami Miller School of Medicine, conducted an investigation in a select population of healthy volunteers after oculofacial surgery by examining the postoperative course and medical records of a total of 27 patients (16 females, 11 males) with age range from18 to 70 years using topical Arnica and Ledum after undergoing common oculofacial procedures, including blepharoplasty, browpexy, and rhinoplasty, in the hands of 4 surgeons at tertiary referral centers from July 1, 2012 to December 31, 2012.
According to the result of the experiment, application of Arnica 50 M (10) 50% and Ledum 50 M (10) pads bilaterally after surgery through postoperative day 6, showed a significantly accelerated healing from day 7 to day 12 in dose depending manner, without inflicting any adverse effects.
The findings suggested that application of composited Arnica and Ledum displays a potential efficacy in reducing postoperative ecchymosis and edema after oculofacial surgery.
The above differentiation of herbal Arnica in improved edema after surgery was supported by the joint study led by the Research Center of University of adult male Wistar rats inoculated with 1% carrageenan into the footpad to induce edema then treated with Arnica montana 6cH, dexamethasone (4.0 mg/kg; positive control) or 5% hydroalcoholic solution (negative control), per os, each 15 minutes, between 30 and 180 minutes after the irritant inoculation.
According to the investigation, application of Arnica group exhibited anti-edema through increased lymphatic edema absorption, particularly, in late edema and less intense edema treatment group after adjusting to the individually qualitative of inflammatory vascular events.
Moreover, the edema inhibition of Arnica was attributed to significantly reduced mast cell degranulation and increased lymphatic vessels diameter and decreased the production of prostaglandins associated to the development of edema, caused by subcutaneous carrageenan injection in the induction of local inflammation.
Taken together, herbal Arnica may be considered as a functional food in reduced risk, progression and for treatment of edema and ecchymosis.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blog, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) A randomized, controlled comparison between arnica and steroids in the management of postrhinoplasty ecchymosis and edema by Totonchi A1, Guyuron B.(PubMed)
(2) Assessing the Effectiveness of Arnica montana and Rhododendron tomentosum (Ledum palustre) in the Reduction of Ecchymosis and Edema After Oculofacial Surgery: Preliminary Results by Kang JY1, Tran KD, Seiff SR, Mack WP, Lee WW. (PubMed)
(3) Inflammatory Process Modulation by Homeopathic Arnica montana 6CH: The Role of Individual Variation Ana Paula Kawakami,1 Cesar Sato,1 Thayna Neves Cardoso,1 and Leoni Villano Bonamin(Hindawi)
(4) Pathogenesis of sodium and water retention in edematous disorders by Paller MS, Schrier RW(PubMed)
Wednesday, October 3, 2018
How To Protect Your Eyes Against Retinal Degeneration
Green tea phenolic content may have a sustainable and therapeutic effect in reduced risk and progression of retinal degeneration, some scientists suggested.
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in natural herbal medicine or food, long-term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weakening immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
Retinal degeneration is a macular disease characterized by impaired vision, night blindness, retinal detachment, light sensitivity, tunnel vision, and loss of peripheral vision to total loss of vision.
The evaluation of green tea effect in risk of retinal degeneration was found to be implicated by several mechanisms through numbers of aspects.
In ROS implication of oxidative stress-induced degeneration of the retina occurred in age-related macular degeneration (AMD) and glaucoma, application of green tea polyphenols epigallocatechin gallate (EGCG) exhibited antioxidant effect as free radical scavenger in ameliorated chain reaction of ROS in causing loss of neuron with direct effects of retinal function and reduced cytotoxicity of free radicals in induction of retinal cellular apoptosis.
Administration of green tea phenolic compound exerted 10 times more effective in the treatment of retinal degeneration, in compared to potent medicine Trolox (vitamin E analog) in attenuating lipid peroxidation caused by the nitric oxide donor, sodium nitroprusside (SNP), according to the study.
Particularly, green tea epigallocatechin gallate (EGCG) inhibited a significant decrease of photoreceptor-specific markers (RET-P1, rhodopsin kinase), an indication of photoreceptor cells in the transition to degenerate prematurely, eventually resulting in blindness.
Also, the application reduced an increase in the cell death marker caspase-3 caused by oxidative stress induced by injection of sodium nitroprusside (SNP)
Caspase 3 is an important marker of apoptosis and one of side effect of sodium nitroprusside (SNP) is cyanide toxicity, that can induce overexpression ROS in facilitated free radical chain reaction.
According to the observation by Western blotting techniques, SNP was completely inhibited by EGCG injection in ameliorated the detrimental effects to the retina.
Dr. Zhang B, the co-author said, "Since oxidative stress has been implicated in retinal diseases like AMD and glaucoma this study provides "proof of principle" for the idea that daily intake of EGCG may help individuals suffering from retinal diseases where oxidative stress is implicated".
More interestingly, BALB/cJ mice treated with either EGCG or saline via intraperitoneal (IP) injection, and then placed under constant cool white light-emitting diode (LED) light (10,000 lux) for 5 h, showed a strong protective effect on the retina against light damage (LD) in compared to the control group.
In the examine the retinal structure and function after LD, according to the optical coherence tomography (OCT) and electroretinography (ERG), application of green tea EGCG improved significantly higher ERG amplitudes for all three wave types through inducing morphologic protection of photoreceptors in compared to control.
Moreover, the green tea extract bio-compound also decreased oxidative stress through increase the mRNA level of the antioxidant expression of Sod2, a manganese-dependent superoxide dismutase (MnSOD) before LD and 24 h after LD.
Dr. Qi S1,, the lead author said, "The IP injection of EGCG attenuated the detrimental effects of bright light on the retinas of BALB/cJ mice by protecting the structure and function of the retina".
Importantly, in the study to evaluate green tea EGCG effect in reduced glutamate and induced excitotoxicity in the retina, researchers conducted a study of female Wistar rats (n = 171) randomly assigned into
*. A normal control group (n = 9);
*. A saline control group with intravitreal saline injections (n = 54);
*. NMDA control group with an intravitreal NMDA injection;
*. Intraperitoneal saline injections (n = 54); and
*. NMDA study group (n = 54) receiving an intravitreal NMDA injection plus intraperitoneal EGCG (25 mg/kg) injections.
Observation of the groups at 2 weeks after additional injection of NMDA, showed that group treated with intraperitoneal application of EGCG reduced a significantly less marked NMDA-associated loss of retinal ganglion cell, through
* Inhibition of decreasing retinal ganglion cell layer (GCL), neurons located near the inner surface (the ganglion cell layer) of the retina of the eye in received visual information from photoreceptors.
These results were observed by differentiation of Thy-1 immunoreactivity in several areas of the immature and adult human brain in the expression of retinal ganglion cell damage.
Thy-1 is mostly is expressed by the ganglion cells within the retina and used to index ganglion cell death after ischemia and excitotoxicity. and NMDA excitotoxicity is associated with the death of retinal ganglion cells (RGCs).
Taken together, there is no doubt that Epigallocatechin-3-gallate (EGCG), a major polyphenol of green tea, may be used a combination with standard therapy for protection and treatment of retinal degenerative disease
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299
Green tea, a precious drink processes numbers of health benefit known to almost everyone in Asia and Western world. However, as yin in natural herbal medicine or food, long-term injection of large amounts may obstruct the balance of yin-yang, induced "yin excessive syndrome" or "yang vacuity syndrome" including weakening immunity and painful case of GERD,... according to traditional Chinese medicine's Yin-Yang theory.
Retinal degeneration is a macular disease characterized by impaired vision, night blindness, retinal detachment, light sensitivity, tunnel vision, and loss of peripheral vision to total loss of vision.
The evaluation of green tea effect in risk of retinal degeneration was found to be implicated by several mechanisms through numbers of aspects.
In ROS implication of oxidative stress-induced degeneration of the retina occurred in age-related macular degeneration (AMD) and glaucoma, application of green tea polyphenols epigallocatechin gallate (EGCG) exhibited antioxidant effect as free radical scavenger in ameliorated chain reaction of ROS in causing loss of neuron with direct effects of retinal function and reduced cytotoxicity of free radicals in induction of retinal cellular apoptosis.
Administration of green tea phenolic compound exerted 10 times more effective in the treatment of retinal degeneration, in compared to potent medicine Trolox (vitamin E analog) in attenuating lipid peroxidation caused by the nitric oxide donor, sodium nitroprusside (SNP), according to the study.
Particularly, green tea epigallocatechin gallate (EGCG) inhibited a significant decrease of photoreceptor-specific markers (RET-P1, rhodopsin kinase), an indication of photoreceptor cells in the transition to degenerate prematurely, eventually resulting in blindness.
Also, the application reduced an increase in the cell death marker caspase-3 caused by oxidative stress induced by injection of sodium nitroprusside (SNP)
Caspase 3 is an important marker of apoptosis and one of side effect of sodium nitroprusside (SNP) is cyanide toxicity, that can induce overexpression ROS in facilitated free radical chain reaction.
According to the observation by Western blotting techniques, SNP was completely inhibited by EGCG injection in ameliorated the detrimental effects to the retina.
Dr. Zhang B, the co-author said, "Since oxidative stress has been implicated in retinal diseases like AMD and glaucoma this study provides "proof of principle" for the idea that daily intake of EGCG may help individuals suffering from retinal diseases where oxidative stress is implicated".
More interestingly, BALB/cJ mice treated with either EGCG or saline via intraperitoneal (IP) injection, and then placed under constant cool white light-emitting diode (LED) light (10,000 lux) for 5 h, showed a strong protective effect on the retina against light damage (LD) in compared to the control group.
In the examine the retinal structure and function after LD, according to the optical coherence tomography (OCT) and electroretinography (ERG), application of green tea EGCG improved significantly higher ERG amplitudes for all three wave types through inducing morphologic protection of photoreceptors in compared to control.
Moreover, the green tea extract bio-compound also decreased oxidative stress through increase the mRNA level of the antioxidant expression of Sod2, a manganese-dependent superoxide dismutase (MnSOD) before LD and 24 h after LD.
Dr. Qi S1,, the lead author said, "The IP injection of EGCG attenuated the detrimental effects of bright light on the retinas of BALB/cJ mice by protecting the structure and function of the retina".
Importantly, in the study to evaluate green tea EGCG effect in reduced glutamate and induced excitotoxicity in the retina, researchers conducted a study of female Wistar rats (n = 171) randomly assigned into
*. A normal control group (n = 9);
*. A saline control group with intravitreal saline injections (n = 54);
*. NMDA control group with an intravitreal NMDA injection;
*. Intraperitoneal saline injections (n = 54); and
*. NMDA study group (n = 54) receiving an intravitreal NMDA injection plus intraperitoneal EGCG (25 mg/kg) injections.
Observation of the groups at 2 weeks after additional injection of NMDA, showed that group treated with intraperitoneal application of EGCG reduced a significantly less marked NMDA-associated loss of retinal ganglion cell, through
* Inhibition of decreasing retinal ganglion cell layer (GCL), neurons located near the inner surface (the ganglion cell layer) of the retina of the eye in received visual information from photoreceptors.
These results were observed by differentiation of Thy-1 immunoreactivity in several areas of the immature and adult human brain in the expression of retinal ganglion cell damage.
Thy-1 is mostly is expressed by the ganglion cells within the retina and used to index ganglion cell death after ischemia and excitotoxicity. and NMDA excitotoxicity is associated with the death of retinal ganglion cells (RGCs).
Taken together, there is no doubt that Epigallocatechin-3-gallate (EGCG), a major polyphenol of green tea, may be used a combination with standard therapy for protection and treatment of retinal degenerative disease
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299
Sources
(1) Oxidative-induced retinal degeneration is attenuated by epigallocatechin gallate by Zhang B1, Osborne NN(PubMed)
(2) Neuroprotective effect of epigallocatechin-3-gallate against N-methyl-D-aspartate-induced excitotoxicity in the adult rat retina by Chen F1, Jiang L, Shen C, Wan H, Xu L, Wang N, Jonas JB(PubMed)
(3) Intraperitoneal injection of (-)-Epigallocatechin-3-gallate protects against light-induced photoreceptor degeneration in the mouse retina by Qi S1,2, Wang C1,2, Song D2, Song Y2, Dunaief JL2. (PubMed)--
(1) Oxidative-induced retinal degeneration is attenuated by epigallocatechin gallate by Zhang B1, Osborne NN(PubMed)
(2) Neuroprotective effect of epigallocatechin-3-gallate against N-methyl-D-aspartate-induced excitotoxicity in the adult rat retina by Chen F1, Jiang L, Shen C, Wan H, Xu L, Wang N, Jonas JB(PubMed)
(3) Intraperitoneal injection of (-)-Epigallocatechin-3-gallate protects against light-induced photoreceptor degeneration in the mouse retina by Qi S1,2, Wang C1,2, Song D2, Song Y2, Dunaief JL2. (PubMed)--
Monday, October 1, 2018
How to Mediate Your Sex Hormone to the Body Needed Naturally
Coffee, a popular and social beverage, is a drink made from roasted bean from the Coffea plant, native to tropical Africa and Madagascar.
A recent study suggested that coffee may have a direct effect on the influence of sex hormone steroid-binding globulin(SSBG) in the stimulated production of estrogen and testosterone depending to levels in the host.
Sex hormones are a class of hormones, affecting sexual development or reproduction. Steroid-binding globulin(SSBG), is a sex hormone, having a direct effect on androgen and estrogen.
In sex hormones and sexual differentiation, the most influential hormone in human sexual desire is testosterone.
Low levels of estrogen in women can also reduce sex drive caused by vaginal dryness that can lead to painful intercourse
Mentally, women with low levels of estrogen also experience unstable mood and sleep patterns that can have a strong impact on sexual desire.
However, sexual motivation is influenced by a set of hormones, including testosterone, estrogen, progesterone, oxytocin, and vasopressin...... Altogether, they control the ability to engage in sexual behaviors.
In an 8-week parallel-arm randomized controlled trial with Healthy adults (n = 42) recruited from the Boston community, including regular coffee consumers, nonsmokers, and overweight, randomized to five 6-ounce cups of caffeinated or decaffeinated instant coffee or water per day, at 4 weeks, researchers surprisingly found that
* Decaffeinated coffee drinking was associated with a borderline significantly increased levels of SHBG in women, but not in men.
*. At week 4, decaffeinated coffee decreased total and free testosterone and caffeinated coffee decreased only total testosterone in women.
*. Contrast to women participants, men consumption of caffeinated coffee displayed a significantly increased total testosterone and decreased total and free estradiol hormones.
*. The study also indicated that caffeinated coffee consumption does not exert any effect on SHBG in either men or women.
These results suggested that intake of coffee may have a strong impact in maintained normal levels of SHBG, thus reducing the risk of low levels of SHBG induced higher testosterone levels in overweight women, which can lead to androgenization and development of the polycystic ovarian syndrome.
And in men, higher levels of testosterone may also have a significant contribution of healthy libido, building muscle mass, and maintaining energy levels.
Some researchers suggested that increased testosterone level for middle-aged (30 to 50 years old) and older males may also improve the physical energy, strength, stamina, mental aggressiveness which were lost in the aging population.
Contrast to above differentiation, in type 2 diabetic patients, coffee and coffee caffeine showed an elevated effect as a mediator of sex hormone-binding globulin in both androgen and estrogen particularly in women in compared to the healthy young adult.
Dr. Eric L. Ding and colleagues in the study to evaluate "Sex Hormone–Binding Globulin and Risk of Type 2 Diabetes in Women and Men" said, " Among women, higher plasma levels of sex hormone–binding globulin were prospectively associated with a lower risk of type 2 diabetes and " the predicted odds ratio of type 2 diabetes per standard-deviation increase in the plasma level of sex hormone–binding globulin was 0.28 (95% CI, 0.13 to 0.58) among women and 0.29 (95% CI, 0.15 to 0.58) among men".
The analysis strongly suggested that coffee regardless of types have a negative correlation with risk of diabetes through increasing levels of SHBG.
Additionally, according to the cross-sectional study of 2377 nondiabetic pre- and postmenopausal women from the E3N cohort study in a multivariate-adjusted model, intake of more than 3 cups of coffee daily coffee and caffeine ≥265 mg/day were associated with an increased SHBG level distribution (<46.3 nmol/L), in compared to no risk association of decaffeinated coffee subgroup.
In other words, in low levels of SHBG nondiabetic pre- and postmenopausal in compared to healthy women, injection of caffeinated coffee increased levels of sex hormones estrogen and testosterone
The above analysis was supported by the examination of the study during a median follow-up of 10 years of 359 postmenopausal women with newly diagnosed type 2 diabetes matched with 359 control subjects by age, race, duration of follow-up, and time of blood draw, coffee and caffeine were associated with increased levels of free and total testosterone among postmenopausal women.
In Summary, the evidence indicated that coffee and caffeine have an extreme effect in an exhibition of sex hormone estrogen and testosterone through the increased lower level of SHBG in menopause women and prevented the onset of type 2 diabetes without affecting the serum in healthy individuals.
Decaffeinated coffee decreased total and free testosterone through significantly increased levels of SHBG in overweight women who are at risk of diseases associated to over expression of testosterone.
And caffeinated coffee displayed a significantly increased total testosterone and decreased total and free estradiol in men.
Altogether, coffee may be considered as a function food in the mediated production of sexual hormone estrogen and testosterone against diseases and syndromes caused by low levels of SSBG.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
A recent study suggested that coffee may have a direct effect on the influence of sex hormone steroid-binding globulin(SSBG) in the stimulated production of estrogen and testosterone depending to levels in the host.
Sex hormones are a class of hormones, affecting sexual development or reproduction. Steroid-binding globulin(SSBG), is a sex hormone, having a direct effect on androgen and estrogen.
In sex hormones and sexual differentiation, the most influential hormone in human sexual desire is testosterone.
Low levels of estrogen in women can also reduce sex drive caused by vaginal dryness that can lead to painful intercourse
Mentally, women with low levels of estrogen also experience unstable mood and sleep patterns that can have a strong impact on sexual desire.
However, sexual motivation is influenced by a set of hormones, including testosterone, estrogen, progesterone, oxytocin, and vasopressin...... Altogether, they control the ability to engage in sexual behaviors.
In an 8-week parallel-arm randomized controlled trial with Healthy adults (n = 42) recruited from the Boston community, including regular coffee consumers, nonsmokers, and overweight, randomized to five 6-ounce cups of caffeinated or decaffeinated instant coffee or water per day, at 4 weeks, researchers surprisingly found that
* Decaffeinated coffee drinking was associated with a borderline significantly increased levels of SHBG in women, but not in men.
*. At week 4, decaffeinated coffee decreased total and free testosterone and caffeinated coffee decreased only total testosterone in women.
*. Contrast to women participants, men consumption of caffeinated coffee displayed a significantly increased total testosterone and decreased total and free estradiol hormones.
*. The study also indicated that caffeinated coffee consumption does not exert any effect on SHBG in either men or women.
These results suggested that intake of coffee may have a strong impact in maintained normal levels of SHBG, thus reducing the risk of low levels of SHBG induced higher testosterone levels in overweight women, which can lead to androgenization and development of the polycystic ovarian syndrome.
And in men, higher levels of testosterone may also have a significant contribution of healthy libido, building muscle mass, and maintaining energy levels.
Some researchers suggested that increased testosterone level for middle-aged (30 to 50 years old) and older males may also improve the physical energy, strength, stamina, mental aggressiveness which were lost in the aging population.
Contrast to above differentiation, in type 2 diabetic patients, coffee and coffee caffeine showed an elevated effect as a mediator of sex hormone-binding globulin in both androgen and estrogen particularly in women in compared to the healthy young adult.
Dr. Eric L. Ding and colleagues in the study to evaluate "Sex Hormone–Binding Globulin and Risk of Type 2 Diabetes in Women and Men" said, " Among women, higher plasma levels of sex hormone–binding globulin were prospectively associated with a lower risk of type 2 diabetes and " the predicted odds ratio of type 2 diabetes per standard-deviation increase in the plasma level of sex hormone–binding globulin was 0.28 (95% CI, 0.13 to 0.58) among women and 0.29 (95% CI, 0.15 to 0.58) among men".
The analysis strongly suggested that coffee regardless of types have a negative correlation with risk of diabetes through increasing levels of SHBG.
Additionally, according to the cross-sectional study of 2377 nondiabetic pre- and postmenopausal women from the E3N cohort study in a multivariate-adjusted model, intake of more than 3 cups of coffee daily coffee and caffeine ≥265 mg/day were associated with an increased SHBG level distribution (<46.3 nmol/L), in compared to no risk association of decaffeinated coffee subgroup.
In other words, in low levels of SHBG nondiabetic pre- and postmenopausal in compared to healthy women, injection of caffeinated coffee increased levels of sex hormones estrogen and testosterone
The above analysis was supported by the examination of the study during a median follow-up of 10 years of 359 postmenopausal women with newly diagnosed type 2 diabetes matched with 359 control subjects by age, race, duration of follow-up, and time of blood draw, coffee and caffeine were associated with increased levels of free and total testosterone among postmenopausal women.
In Summary, the evidence indicated that coffee and caffeine have an extreme effect in an exhibition of sex hormone estrogen and testosterone through the increased lower level of SHBG in menopause women and prevented the onset of type 2 diabetes without affecting the serum in healthy individuals.
Decaffeinated coffee decreased total and free testosterone through significantly increased levels of SHBG in overweight women who are at risk of diseases associated to over expression of testosterone.
And caffeinated coffee displayed a significantly increased total testosterone and decreased total and free estradiol in men.
Altogether, coffee may be considered as a function food in the mediated production of sexual hormone estrogen and testosterone against diseases and syndromes caused by low levels of SSBG.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrients
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) The effects of caffeinated and decaffeinated coffee on sex hormone-binding globulin and endogenous sex hormone levels: a randomized controlled trial by Wedick NM1, Mantzoros CS, Ding EL, Brennan AM, Rosner B, Rimm EB, Hu FB, van Dam RM.( PubMed)
(2) Cross-sectional association of coffee and caffeine consumption with sex hormone-binding globulin in healthy nondiabetic women by Pihan-Le Bars F1,2, Gusto G3,4,5, Boutron-Ruault MC3,4,5, Fagherazzi G3,4,5, Bonnet F1,2,3.(PubMed)
(3) Coffee and caffeine consumption in relation to sex hormone-binding globulin and risk of type 2 diabetes in postmenopausal women by Goto A1, Song Y, Chen BH, Manson JE, Buring JE, Liu S.(PubMed)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) The effects of caffeinated and decaffeinated coffee on sex hormone-binding globulin and endogenous sex hormone levels: a randomized controlled trial by Wedick NM1, Mantzoros CS, Ding EL, Brennan AM, Rosner B, Rimm EB, Hu FB, van Dam RM.( PubMed)
(2) Cross-sectional association of coffee and caffeine consumption with sex hormone-binding globulin in healthy nondiabetic women by Pihan-Le Bars F1,2, Gusto G3,4,5, Boutron-Ruault MC3,4,5, Fagherazzi G3,4,5, Bonnet F1,2,3.(PubMed)
(3) Coffee and caffeine consumption in relation to sex hormone-binding globulin and risk of type 2 diabetes in postmenopausal women by Goto A1, Song Y, Chen BH, Manson JE, Buring JE, Liu S.(PubMed)
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