Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
1. Phytochemical Allicin and anti bacterial activity
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
The immune system is the set of cells and their activity against antigens or infectious agents that comprises of the body's defense system against diseases. The immune system does a great job of keeping people healthy and preventing infections. Beside foods and nutritional supplements, herbs also play a important role in helping the immune system defend against viruses and bacteria attacks.
The Benefits
Garlic has been used as foods and medicine throughout human history. Allicin, major constituent of garlic in the test for the antimicrobial activity on oral pathogens associated with dental caries and periodontitis, showed an effectiveness against all types of bacteria, including Streptococcus mutans, S. sobrinus, and Actinomyces oris. Other in the study of Streptolysin O (SLO), a potent cytolytic toxin produced by almost all strains of group A streptococci, found that allicin likely inhibits the SLO by binding to the cysteine residue in the binding site and suggested that allicin and allicin may be a potential alternative drug against streptococcal diseases.
References
(1) Garlic allicin as a potential agent for controlling oral pathogens by Bachrach G, Jamil A, Naor R, Tal G, Ludmer Z, Steinberg D.(PubMed)
(2) Inhibition of streptolysin O by allicin - an active component of garlic by Arzanlou M, Bohlooli S.(PubMed)
2. Phytochemical Allicin and anti cognitive activity
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
Cognition is the process of the brain including the attention of working memory, producing and comprehending language, learning, reasoning, problem solving, and decision making.
The benefits
Cognitive abilities tend to decline in aging. The study of allicin on endogenous antioxidant defenses in hippocampus of cognitively impaired aged mouse, showed a positive effects as allicin significantly ameliorated ageing-induced cognitive dysfunction through enhancing of Nrf2 antioxidant signaling pathways. Allcin also exerted its antioxidant effect in reducing the risk of cardiovascular disease, stroke, cancer and aging, including the oxidant-mediated brain cell damage that is implicated in Alzheimer's disease.
References
(1) Cognition (Wikipedia)
(2) Allicin ameliorates cognitive deficits ageing-induced learning and memory deficits through enhancing of Nrf2 antioxidant signaling pathways by Li XH, Li CY, Lu JM, Tian RB, Wei J.(PubMed)
(3) Antioxidant health effects of aged garlic extract by Borek C.(PubMed)
3. Phytochemical Allicin and cardiovascular diseases
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
There are many causes of heart diseases. Most of heart diseases are caused by high blood pressure contributes to hardening of the arteries. High levels of bad cholesterol (LDL) build up in the arteries as a result of uncontrolled diet with high levels of saturated fat and trans fat. All these add to the formation of atherosclerosis lesions and eventually arterial blockage or anything that serves to damage the inner lining of blood vessels and impedes the transportation of oxygen and nutrition to the heart can be defined as a risk of heart disease.
The health benefits
It is known that allicin, found in garlic and onion is easily absorbed after intake to exert it effects in circulation system without damaging the to the phospholipid bilayer made of two layers of lipid molecules to provide cardio-protective effects including cardiac hypertrophy, angiogenesis, platelet aggregation, hyperlipidemia and hyperglycemia. Other in the study of allicin effect on vascular endothelium dysfunction in healthy male Wistar rats, fed high fat diet in comparison with fenofibrate, fenofibrate alone or the combined therapy with allicin increased the levels of high density lipoprotein, the levels of NO, but the combined therapy had greatest high endothelium-dependent vascular relaxation responses of blood vessel.
References
(1) The effect of combination therapy of allicin and fenofibrate on high fat diet-induced vascular endothelium dysfunction and liver damage in rats by Li W, Wang D, Song G, Zuo C, Qiao X, Qin S.(PubMed)
(2) Endothelium-derived relaxing and contracting factors by R F Furchgott and P M Vanhoutte
(The Fasteb JournaL)
(3) The effect of combination therapy of allicin and fenofibrate on high fat diet-induced vascular endothelium dysfunction and liver damage in rats BY Li W, Wang D, Song G, Zuo C, Qiao X, Qin S.(PubMed)
(4) A review of the cardiovascular benefits and antioxidant properties of allicin by Chan JY, Yuen AC, Chan RY, Chan SW.(PubMed)
4. Phytochemical Allicin as antioxidants
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
A free radical is any atom or molecule that has a single unpaired electron in an outer shell and highly reactive to react with other cell, which in turn, causes oxidative damage to the enzymes, other protein, unsaturated fatty acid, phospho-lipids, DNA and RNA, etc., leading to aging of the organisms, as a result of widespread damage due to set of a chain reaction auto-catalytically after attacking the lipid bilayers of the cell walls.
The health benefits
Beside with protective effect against development of certain diseases, allicin found in garlic and onion may also be a antioxidant scarvenger of oxygen free radicals (OFRs). In the study of allicin effect in hydroxyl radicals (.OH), researcher found that allicin prevented the lipid peroxidation of malondialdehyde in liver homogenate in a concentration-dependent manner. Other in the study of the hydroxyl scavengers of allyl cysteine, alliin, allicin, and allyl disulfide, showed that allicin did not exhibit hydroxyl radical scavenging but exhibited antioxidant activities as protective compounds against free radical damage.
References
(1) Antioxidant activity of allicin, an active principle in garlic by Prasad K, Laxdal VA, Yu M, Raney BL.(PubMed)
(2) The antioxidant properties of garlic compounds: allyl cysteine, alliin, allicin, and allyl disulfide by Chung LY.(PubMed)
5. Phytochemical allicin and hypertension
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood. High blood pressure means raising pressure in your heart.If it stays high over time it can damage the body in many ways.
Blood pressure medications have undoubtedly prevented many deaths from heart disease in the past 30 years, but they have many side effects such as damaging the kidney. If you can control your diet, such as making changes to lifestyle, maintaining ideal weight and diet with low salt, you could do just fine without the drugs.
The health benefits
Allicin, found in garlic and onion may consist an antihypertensive effects by lowering the systolic and diastolic blood pressure. In the study of a popular garlic preparation containing 1.3% allicin at a large dose (2400 mg) in nine patients with rather severe hypertension, after 5 hours taking the preparation, sitting blood pressure fell 7/16, with a significant decrease in diastolic blood pressure from 5-14 hours after the dose. Other in the study of the hypotensive action of time-released garlic powder tablets (Allicor) and compared with that of regular garlic pills (Kwai) in 84 men with mild or moderate arterial hypertension, the result indicated that both Kwai and garlic powder tablets decrease in systolic blood pressure but no decrease in diastolic blood pressure was observed with Kwai. These different effects may be as a result of the prolonged action of Allicor.
References
(1) Can garlic lower blood pressure? A pilot study by McMahon FG, Vargas R.(PubMed)
(2) Time-released garlic powder tablets lower systolic and diastolic blood pressure in men with mild and moderate arterial hypertension by Sobenin IA, Andrianova IV, Fomchenkov IV, Gorchakova TV, Orekhov AN.(PubMed)
6. Phytochemical Allicin and hyper cholesterol
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
Cholesterol is needed for our body to build cell walls, make hormones and vitamin D, and create bile salts that help you digest fat. However too much of it can be dangerous because cholesterol cannot dissolve in your blood. The special particle called lipoprotein moves this waxy, soft substance from place to place. If you have too much low density lipoprotein LDL that is known as bad cholesterol, overtime cholesterol can build up in your arterial walls causing blockage and leading to heart attack and stroke.
The health benefits
Evidences emerging that allicin may not only benefit in preventing and treating cardiovascular disease but also lower the blood cholesterol. In the study of the effect of allicin on hypercholesterolemia in male ICR mice, the chemical constituent of garlic showed a positive effect not in reducing blood cholesterol, triglycerides, and glucose levels , as well as lowering the hepatic cholesterol storage, but also decreasing appetite daily. Other in the study of the same but woth rat fed with high cholesterol diet, showed a reduction of blood cholesterol, triglycerides levels and systolic blood pressure in hypercholesterolemic rats. These result showed that allicin may be considered as a potent agent in treating hypercholesterol in the future.
References
(1) Cholesterol-lowering effect of allicin on hypercholesterolemic ICR mice, Lu Y, He Z, Shen X, Xu X, Fan J, Wu S, Zhang D.(PubMed)
(2) Effect of allicin from garlic powder on serum lipids and blood pressure in rats fed with a high cholesterol diet by Ali M, Al-Qattan KK, Al-Enezi F, Khanafer RM, Mustafa T.(PubMed)
7. Allicin and anti fungal effects
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
Cholesterol is needed for our body to build cell walls, make hormones and vitamin D, and create bile salts that help you digest fat. However too much of it can be dangerous because cholesterol cannot dissolve in your blood. The special particle called lipoprotein moves this waxy, soft substance from place to place. If you have too much low density lipoprotein LDL that is known as bad cholesterol, overtime cholesterol can build up in your arterial walls causing blockage and leading to heart attack and stroke.
The immune system is the set of cells and their activity against antigens or infectious agents that comprises of the body's defense system against diseases. The immune system does a great job of keeping people healthy and preventing infections. Beside foods and nutritional supplements, herbs also play a important role in helping the immune system defend against viruses and bacteria attacks.
The health effects
Beside controlling the domino's effect of free radicals during the stage of oxidation, allicin, the chemical constituent of garlic also expressed its anti fungal activity by enhancing the cell immunity with its breakdown products with out damaging to the cells. In candidiasis study, allicin exerted its anti fungal property against C. albicans, C. glabrata and C. tropicalis,in doses depending manner, including drug resistance Candida species.
References
(1) An overview of the antifungal properties of allicin and its breakdown products--the possibility of a safe and effective antifungal prophylactic by Davis SR.(PubMed)
(2) In vitro investigation of antifungal activity of allicin alone and in combination with azoles against Candida species by Khodavandi A, Alizadeh F, Aala F, Sekawi Z, Chong PP.(PubMed)
8. Phytochemical allicin and anti microbial activity
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
The immune system is the set of cells and their activity against antigens or infectious agents that comprises of the body's defense system against diseases. The immune system does a great job of keeping people healthy and preventing infections. Beside foods and nutritional supplements, herbs also play a important role in helping the immune system defend against viruses and bacteria attacks.
The health benefits
Allicin, the chemical compound of garlic is found to show a positive effect against infectious diseases caused by Gram-negative and Gram-positive bacteria. In parasite study, allicin inetracted with thiol groups of various enzymes against some major human intestinal protozoan parasites such as Entamoeba histolytica and Giardia lamblia; and iv). In recent publication, garlic extract is found to contain a broad-spectrum antimicrobial activity against many genera of bacteria and fungi. There result indicated that garlic may play an important role in the ecological control of pathogenic microorganisms in nature.
References
(1) Antimicrobial properties of allicin from garlic by Ankri S, Mirelman D.(PubMed)
(2) Allium sativum (garlic)--a natural antibiotic by Adetumbi MA, Lau BH (PubMed)
9. Phytochemical allicin and malaria
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
Malaria, a mosquito-borne infectious disease caused by parasitic protozoans
The health effects
Malaria has infected millions of people a year in the third world. The urgency in finding a natural existence agent in treating the diseases with less economical cost is become necessary. Allicin, found in garlic, may be one of them, as it enhanced the immune reponses of the host to reduce parasitaemia and prolong the survival of the host in a dose-dependent manner. In vivo, mice injected with allicin had found to decrease the levels of Plasmodium infections compared to controls, prevent sporozoites cause of malaria when allicin was injection into mice before induction. orally or intravenously of allicin also significantly decreased parasitemias and increased the survival of infected mice by 10 days.
References
(1) Allicin enhances host pro-inflammatory immune responses and protects against acute murine malaria infection by Feng Y, Zhu X, Wang Q, Jiang Y, Shang H, Cui L, Cao Y.(PubMed)
(2) Antimalarial activity of allicin, a biologically active compound from garlic cloves by Coppi A, Cabinian M, Mirelman D, Sinnis P.(PubMed)
10. Phytochemical allicin and Colon cancer
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
Colon Cancer is defined as a condition of the abnormal proliferation of cells in the colon.
The health effects
Allicin, a biologically active component in freshly crushed garlic extract, in the study of its effects against colon cancer cell lines HCT-116, LS174T, HT-29, and Caco-2, showed that allicin exert it anti proliferative property to cause death of HCT-116 cell. Other in the study of the effect of allicin on human colon cancer cell line LoVo and the combined effect of allicin and CPT-11 on this cancer cell line, showed that allicin may be a potent agent in treating colon cancer as it not only exerted the anti-proliferation effect on human colon cancer cell line LoVo by induction of apoptosis and arrestment of cell cycle but also enhanced the cytotoxicity of CPT-11 on the colon cancer LoVo cell.
References
(1) Allicin purified from fresh garlic cloves induces apoptosis in colon cancer cells via Nrf2 by Bat-Chen W, Golan T, Peri I, Ludmer Z, Schwartz B.(PubMed)
(2) [Allicin enhances cytotoxicity of CPT-11 to colon cancer LoVo cell in vitro].
[Article in Chinese] by Gao Y, Liu Y, Cao W, Deng Z, Liu H, Xu L, Chen X.(PubMed)
9. Phytochemical allicin and osteosarcoma
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
Osteosarcoma is a bone cancer found mostly in teenagers and people over age 60.
The health benefits
Phytochemical compounds derived from garlic such as Allicin, diallyl thiosulfinate, have been drawn of interest in cancer treatment research. In the study of the effects of artesunate combined with allicin on osteosarcoma cell lines in vitro and in vivo, found that treatment with artesunate and allicin enhanced the synergistic effects on osteosarcoma cell proliferation and apoptosis. diallyl sulfide (DAS) derived from allicin, in the study of its effect on proliferation of human osteosarcoma MG-63 cells, showed to significantly suppress the growth of MG-63 tumor-bearing tissue. Immunohistochemistry in different concentrations (20 and 40 μg/mL) and decrease microvessel density (MVD) of MG-63 tumor-bearing tissue by suppressing the expression of Vascular endothelial growth factor (VEGF) mRNA.
References
(1) The synergistic anticancer effect of artesunate combined with allicin in osteosarcoma cell line in vitro and in vivo by Jiang W, Huang Y, Wang JP, Yu XY, Zhang LY.(PubMed)
(2) Experimental study on inhibitory effects of diallyl sulfide on growth and invasion of human osteosarcoma MG-63 cells by Hu Y, Chen L, Yi C, Yang F, Chen J.(PubMed)
10. Phytochemical allicin and pancreatic cancer
The health benefits
The prevalence of breast cancer is widespread in develop world as 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during life time of a women is 1/8. Treating breast cancer with natural elements with little or no side eefcts have drawn many interests to the research community. Allicin, generated by oxidation of diallyl disulfide (DADS) may be effective in suppressing breast cancer as in rat study, its activation of metabolizing enzymes that detoxify carcinogens, the suppression of DNA adduct formation, the inhibition of the production of reactive oxygen species (ROS), regulation of cell-cycle arrest, induction of apoptosis as well as reducting the side effects caused by anti-cancer agents.
References
(1) Anticancer effects of garlic and garlic-derived compounds for breast cancer control BY Tsubura A, Lai YC, Kuwata M, Uehara N, Yoshizawa K.(PubMed))
12. Phytochemical allicin and liver cancer
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
Liver cancer is defined as a condition of out of controlled growth of hepatocellular cells in the liver. Since the organ is a soft tissue with less nerve, most liver cancer patient are diagnosed in the later stage of the cancer. According to the statistic, liver cancer remains the fifth most common malignancy in men and the eighth in women worldwide.
Hepatocellular carcinoma (HCC) is a common form of primary liver cancer.
The health benefits
Hepatocellular carcinoma (HCC) is the most prevalent type of liver cancer in Southeast Asia. Anti cancer agent , although effective with many side effects. The urgency in finding of a natural treatment with little or no side effects has drawn many interest. Study showed that allicin induced degradation of cell death in human HCC Hep G2 (p53(wild type)) cells and apoptotic cell death through caspase-dependent and caspase-independent pathways by reactive oxygen species (ROS) overproduction in human cellular tumor antigen p53. on the other hand, Allicin treatment also found to induce apoptotic cell death in p53 knock down Hep G2 cells similar to that of Hep 3B cells. These results suggest that allicin might be a potential novel complementary gene therapeutic agent for the treatment of apoptosis-resistant cancer cells.
References
(1) Allicin induces anti-human liver cancer cells through the p53 gene modulating apoptosis and autophagy by Chu YL, Ho CT, Chung JG, Raghu R, Lo YC, Sheen LY.(PubMed)
(2) Allicin induces anti-human liver cancer cells through the p53 gene modulating apoptosis and autophagy by Chu YL, Ho CT, Chung JG, Raghu R, Lo YC, Sheen LY.(PubMed)
12. Phytochemical allicin and endometrium cancer
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
Endometrium is the inner lining of the mammalian uterus and very susceptible hormone change, particular to menstrual cycle. Endometrial cancer is a late adulthood cancer defined as a condition of which the cells of the endometrial lining of uterus have growth uncontrollable or become cancerous as a result of the alternation of cells DNA. It's the fourth most common cancer among women overall, after breast cancer, lung cancer, and bowel cancer.
The benefits
Although garlic has drawn many interest in scientific community, but believe or not allicin is the least studied. In the study of the effect of allicin's antiproliferative effect in vitro models, showed a significantly inhibited proliferation of human mammary (MCF-7), endometrial (Ishikawa), and colon (HT-29) cancer cells (50% inhibitory concentration = 10-25 microM) attributed to the ability of allicin to transiently deplete the intracellular GSH level.
References
(1) Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation by Hirsch K, Danilenko M, Giat J, Miron T, Rabinkov A, Wilchek M, Mirelman D, Levy J, Sharoni Y.(PubMed)
13. Phytochemical allicin and endometrium cancer
Brain and spinal cord make up the nervous system. Most primary tumors are caused by abnormal cells growth that surround and support neurons, with a small number may be caused by gene defect from exposure to radiation or toxic chemicals. Benign tumors are noncancerous, and malignant tumors are cancerous. More than 190.000 people in US are diagnosed with a brain tumor each year alone. Glioblastoma is the most common and most aggressive malignant primary brain tumor in humans.
The benefits
Allicin, the main flavor compound in garlic, has exerted its anti-carcinogenic activities against a wide range of cancer cells. U87MG is one of a number of cell lines derived from malignant glioma was inhibited, causing apoptosis of cells by allicin in a dose- and time-dependent manner, involve the mitochondrial pathway of Bcl-2/Bax, the MAPK/ERK signaling pathway and antioxidant enzyme systems.
References
(1) Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway by Cha JH, Choi YJ, Cha SH, Choi CH, Cho WH.(PubMed)
14. Phytochemical allicin and gastric cancer
10. Phytochemical allicin and pancreatic cancer
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
Cancer of pancreas or pancreatic cancer is defined as condition of a malignant neoplasm of the pancreas, as the cells have become cancerous and divided uncontrollably. Most pancreatic cancers start in the ducts (exocrine component of the pancreas) that carry pancreatic juices with cancer of an epithelium that originates in glandular tissue accounts for over 75 - 90% of all cases of exocrine cancers.
The health benefits
Allicin found in garlic and onion has drawn many interest in scientific community in finding a natural potent agent with little and no side effects in preventing and treating cancers. Garlic preparations inhibition of cancer cell-growth has been attributed to a group of structurally-related organosulfur compounds, such as allicin, diallyl disulfide and diallyl trisulfide. Combined treatment with recombinant interleukin-2 (rIL-2) on pancreatic cancer and explored the potential immunological mechanism in mice, showed a significant suppression of cells growth and prolonged survival time in the combined treatment with allicin and rIL-2 group, with increased mature Th cells express the surface protein CD4 and CD8, natural killer cell (NK cell) and Serum levels of interferon-gamma.
References
(1) Effect of combined treatment with recombinant interleukin-2 and allicin on pancreatic cancer by Wang CJ, Wang C, Han J, Wang YK, Tang L, Shen DW, Zhao Y, Xu RH, Zhang H.(PubMed)
(2) Anti-proliferation activity of synthetic ajoene analogues on cancer cell-lines by Kaschula CH, Hunter R, Hassan HT, Stellenboom N, Cotton J, Zhai XQ, Parker MI.(PubMed)
11. Phytochemical allicin and breast cancer
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
Breast cancer (malignant breast neoplasm) is a cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk. there is also rare cases that breast cancer starts in other areas of the breast.
Cancer of pancreas or pancreatic cancer is defined as condition of a malignant neoplasm of the pancreas, as the cells have become cancerous and divided uncontrollably. Most pancreatic cancers start in the ducts (exocrine component of the pancreas) that carry pancreatic juices with cancer of an epithelium that originates in glandular tissue accounts for over 75 - 90% of all cases of exocrine cancers.
The health benefits
Allicin found in garlic and onion has drawn many interest in scientific community in finding a natural potent agent with little and no side effects in preventing and treating cancers. Garlic preparations inhibition of cancer cell-growth has been attributed to a group of structurally-related organosulfur compounds, such as allicin, diallyl disulfide and diallyl trisulfide. Combined treatment with recombinant interleukin-2 (rIL-2) on pancreatic cancer and explored the potential immunological mechanism in mice, showed a significant suppression of cells growth and prolonged survival time in the combined treatment with allicin and rIL-2 group, with increased mature Th cells express the surface protein CD4 and CD8, natural killer cell (NK cell) and Serum levels of interferon-gamma.
References
(1) Effect of combined treatment with recombinant interleukin-2 and allicin on pancreatic cancer by Wang CJ, Wang C, Han J, Wang YK, Tang L, Shen DW, Zhao Y, Xu RH, Zhang H.(PubMed)
(2) Anti-proliferation activity of synthetic ajoene analogues on cancer cell-lines by Kaschula CH, Hunter R, Hassan HT, Stellenboom N, Cotton J, Zhai XQ, Parker MI.(PubMed)
11. Phytochemical allicin and breast cancer
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
Breast cancer (malignant breast neoplasm) is a cancer that starts in the tissues of the breast either from the inner lining of milk ducts (Ductal carcinoma) or the lobules (Lobular carcinoma) that supply the ducts with milk. there is also rare cases that breast cancer starts in other areas of the breast.
The health benefits
The prevalence of breast cancer is widespread in develop world as 250,000 new cases of breast cancer were expected to be diagnosed in women in the U.S. alone and the risk of getting invasive breast cancer during life time of a women is 1/8. Treating breast cancer with natural elements with little or no side eefcts have drawn many interests to the research community. Allicin, generated by oxidation of diallyl disulfide (DADS) may be effective in suppressing breast cancer as in rat study, its activation of metabolizing enzymes that detoxify carcinogens, the suppression of DNA adduct formation, the inhibition of the production of reactive oxygen species (ROS), regulation of cell-cycle arrest, induction of apoptosis as well as reducting the side effects caused by anti-cancer agents.
References
(1) Anticancer effects of garlic and garlic-derived compounds for breast cancer control BY Tsubura A, Lai YC, Kuwata M, Uehara N, Yoshizawa K.(PubMed))
12. Phytochemical allicin and liver cancer
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
Liver cancer is defined as a condition of out of controlled growth of hepatocellular cells in the liver. Since the organ is a soft tissue with less nerve, most liver cancer patient are diagnosed in the later stage of the cancer. According to the statistic, liver cancer remains the fifth most common malignancy in men and the eighth in women worldwide.
Hepatocellular carcinoma (HCC) is a common form of primary liver cancer.
The health benefits
Hepatocellular carcinoma (HCC) is the most prevalent type of liver cancer in Southeast Asia. Anti cancer agent , although effective with many side effects. The urgency in finding of a natural treatment with little or no side effects has drawn many interest. Study showed that allicin induced degradation of cell death in human HCC Hep G2 (p53(wild type)) cells and apoptotic cell death through caspase-dependent and caspase-independent pathways by reactive oxygen species (ROS) overproduction in human cellular tumor antigen p53. on the other hand, Allicin treatment also found to induce apoptotic cell death in p53 knock down Hep G2 cells similar to that of Hep 3B cells. These results suggest that allicin might be a potential novel complementary gene therapeutic agent for the treatment of apoptosis-resistant cancer cells.
References
(1) Allicin induces anti-human liver cancer cells through the p53 gene modulating apoptosis and autophagy by Chu YL, Ho CT, Chung JG, Raghu R, Lo YC, Sheen LY.(PubMed)
(2) Allicin induces anti-human liver cancer cells through the p53 gene modulating apoptosis and autophagy by Chu YL, Ho CT, Chung JG, Raghu R, Lo YC, Sheen LY.(PubMed)
12. Phytochemical allicin and endometrium cancer
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
Endometrium is the inner lining of the mammalian uterus and very susceptible hormone change, particular to menstrual cycle. Endometrial cancer is a late adulthood cancer defined as a condition of which the cells of the endometrial lining of uterus have growth uncontrollable or become cancerous as a result of the alternation of cells DNA. It's the fourth most common cancer among women overall, after breast cancer, lung cancer, and bowel cancer.
The benefits
Although garlic has drawn many interest in scientific community, but believe or not allicin is the least studied. In the study of the effect of allicin's antiproliferative effect in vitro models, showed a significantly inhibited proliferation of human mammary (MCF-7), endometrial (Ishikawa), and colon (HT-29) cancer cells (50% inhibitory concentration = 10-25 microM) attributed to the ability of allicin to transiently deplete the intracellular GSH level.
References
(1) Effect of purified allicin, the major ingredient of freshly crushed garlic, on cancer cell proliferation by Hirsch K, Danilenko M, Giat J, Miron T, Rabinkov A, Wilchek M, Mirelman D, Levy J, Sharoni Y.(PubMed)
13. Phytochemical allicin and endometrium cancer
Brain and spinal cord make up the nervous system. Most primary tumors are caused by abnormal cells growth that surround and support neurons, with a small number may be caused by gene defect from exposure to radiation or toxic chemicals. Benign tumors are noncancerous, and malignant tumors are cancerous. More than 190.000 people in US are diagnosed with a brain tumor each year alone. Glioblastoma is the most common and most aggressive malignant primary brain tumor in humans.
The benefits
Allicin, the main flavor compound in garlic, has exerted its anti-carcinogenic activities against a wide range of cancer cells. U87MG is one of a number of cell lines derived from malignant glioma was inhibited, causing apoptosis of cells by allicin in a dose- and time-dependent manner, involve the mitochondrial pathway of Bcl-2/Bax, the MAPK/ERK signaling pathway and antioxidant enzyme systems.
References
(1) Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway by Cha JH, Choi YJ, Cha SH, Choi CH, Cho WH.(PubMed)
Allicin is phytochemical containing sulfur in the class of organosulfur compound, found abundantly in onion and garlic.
Stomach cancer is defined as condition of abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.
The health effects
Allicin, even though is the least studied in scientific community, but its antitumor properties is undeniable in research. Study of the underlying mechanism of allicin on gastric cancer cells, allicin induced apoptosis and inhibited proliferation in gastric cancer cells, through induced cytochrome c release from the mitochondria and increased caspase-3, -8, and -9 activation, with concomitant upregulation of bax and fas expression in the tumor cells. In the effect of allicin on cell proliferation and apoptosis of progressive gastric carcinoma, allicin showed effects in up-regulating the protein expressions of apoptosis promoting gene Bax and apoptosis initiating gene Fas, and down-regulating that of anti-apoptosis gene Bcl-2 via local application of allicinvia gastroscopy.
Refrerences
(1) Allicin induces apoptosis in gastric cancer cells through activation of both extrinsic and intrinsic pathways by Zhang W, Ha M, Gong Y, Xu Y, Dong N, Yuan Y.(PubMed)
(2) [Effect of local application of allicinvia gastroscopy on cell proliferation and apoptosis of progressive gastric carcinoma].[Article in Chinese] by Zhang ZD, Li Y, Jiao ZK.(PubMed)
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Stomach cancer is defined as condition of abnormal growth of the mucus-producing cells of the inside lining of the stomach. Adenocarcinoma is the most common type of stomach cancer.
The health effects
Allicin, even though is the least studied in scientific community, but its antitumor properties is undeniable in research. Study of the underlying mechanism of allicin on gastric cancer cells, allicin induced apoptosis and inhibited proliferation in gastric cancer cells, through induced cytochrome c release from the mitochondria and increased caspase-3, -8, and -9 activation, with concomitant upregulation of bax and fas expression in the tumor cells. In the effect of allicin on cell proliferation and apoptosis of progressive gastric carcinoma, allicin showed effects in up-regulating the protein expressions of apoptosis promoting gene Bax and apoptosis initiating gene Fas, and down-regulating that of anti-apoptosis gene Bcl-2 via local application of allicinvia gastroscopy.
Refrerences
(1) Allicin induces apoptosis in gastric cancer cells through activation of both extrinsic and intrinsic pathways by Zhang W, Ha M, Gong Y, Xu Y, Dong N, Yuan Y.(PubMed)
(2) [Effect of local application of allicinvia gastroscopy on cell proliferation and apoptosis of progressive gastric carcinoma].[Article in Chinese] by Zhang ZD, Li Y, Jiao ZK.(PubMed)
Natural Remedies for Dementia Memory Loss Reversal
Guarantee to Stop Progression and Reverse Memory Loss in Alzheimer and Dementia with step by step instructions through Scientific Studies within 2 Months or your Money back
Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer
For over 100 healthy recipes, http://diseases-researches.blogspot.ca/p/blog-page_17.html
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