Friday, February 24, 2017

Hormone Prostaglandins- Platelet prostaglandin H synthase-1 (PGHS-1) deficiency and Bleeding disorder

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.                     

                      Hormone Prostaglandins

Prostaglandins, are a group of lipid mediators, found and isolated from human semen in the 1930s by Ulf von Euler of Sweden, responsible for inflammation features, such as swelling, pain, stiffness, redness and warmth. The hormones are produced by almost all nucleated cells and synthesized in the cell from the essential fatty acids (EFAs), include prostacyclin I2 (PGI2), prostaglandin E2(PGE2), and prostaglandin F2α (PGF2α)

     Hormone Prostaglandins- Platelet prostaglandin H synthase-1 (PGHS-1) deficiency and Bleeding disorder

Defective platelet prostaglandin H synthase (PGHS) activity has been recognized as a cause of bleeding disorders. In the study of a tatal of three female patients aged 37, 48 and 55 who presented with a mild bleeding disorder due to platelet dysfunction, showed that human platelet PGHS-1 deficiency is due to two types of enzyme defects: type 1 defect is manifested by an undetectable PGHS-1 protein in platelets whereas the type 2 defect is manifested by a normal quantity of PGHS-1 protein which has an impaired catalytic activity(15).


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Sources
(15) http://www.ncbi.nlm.nih.gov/pubmed/8562397
(16) http://www.ncbi.nlm.nih.gov/pubmed/22224182
(17) http://www.ncbi.nlm.nih.gov/pubmed/23013719
(18) http://www.ncbi.nlm.nih.gov/pubmed/22686588
(19) http://www.ncbi.nlm.nih.gov/pubmed/18038902
(20) http://www.ncbi.nlm.nih.gov/pubmed/1717297

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