Health Benefits of Oolong Tea - Neuro- degenerative diseases
a. Toxic amyloid oligomers or fibrils
In the evaluation of Alzheimer's and Parkinson's disease targeting toxic amyloid oligomers or fibrils, in the study of "Black teatheaflavins inhibit formation of toxic amyloid-beta and alpha-synuclein fibrils" by Grelle G, Otto A, Lorenz M, Frank RF, Wanker EE, Bieschke J.[9a], researchers found that theaflavins stimulate the assembly of Aβ(amyloid-beta) and αS(alpha-synuclein) into non-toxic, spherical aggregates and suggested that theaflavins might be useful to remove toxic amyloid deposits in Alzheimer's and Parkinson's disease brains.
b. Lipid Membrane Destabilization
In the assesement of Amyloid-β (Aβ) aggregation is a recognized key process in the pathogenesis of Alzheimer's disease (AD), in the study of "Identification of Polyphenolic Compounds and Black Tea Extract as Potent Inhibitors of Lipid Membrane Destabilization by Aβ42 Aggregates" by Gauci AJ, Caruana M, Giese A, Scerri C, Vassallo N.[9b], researchers found that the small-molecule polyphenols and NBB compounds is particularly effective for protection against membrane damage by the Aβ42 oligomers and suggested that polyphenolsand NBB compounds have played a critical role of membrane perforation in the neurodegenerative cascade.
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