Scientists may have found a chemical constituent isolated from Andrographis paniculata, with potential in reducing risk and treatment of gastric cancer, a respectable institute study suggested.
Gastric/Stomach cancer is a condition of abnormal growth of the mucus-producing cells of the inside lining of the stomach.
Adenocarcinoma is the most common type of gastric cancer.
The causes of gastric cancer are debatable, but some researchers suggested that people with chronic
gastrointestinal reflux disease (GERD), a condition caused by the frequent backflow of stomach acid into the esophagus, is the most likely to develop the disease(4).
Other diseases associated with the early onset of gastric cancer are obesity and smoking(4).
According to the Universidad de Salamanca, bacteria and virus, including Helicobacter pylori are strongly associated with chronic gastritis, clinical syndromes, precancerous lesions, and pathogenesis of gastric cancer development(5).
If you experience some of the symptoms such as feeling bloated after eating, feeling full after only eating small amounts of food, persistent heartburn, and severe indigestion, stomach pain,.... and persistent vomiting, please check with your doctor right the way for the arrangement of a diagnosis(4).
The picture captured during the exam may sometimes be misdiagnosis as an ulcer, a mushroom-shaped or linitis plastica.
If the suspicious area is found, endoscopic ultrasound may be necessary to rule out the cancer onset possibility.
Most importantly, in compared to antioxidant effects in a patient with H. pylori gastritis and gastric cancer, researchers found that concentration of serum superoxide dismutase and serum malondialdehyde that exhibiting oxidative stress caused by overexpression of free radicals are significantly higher and plasma ascorbic acid, the antioxidants are significantly lower in gastric cancer patients.
These results suggested gastric cancer is also associated to the imbalance of ratio of antioxidants produced by the host enzymes and free radical accumulation, leading to elevated ROS that causes oxidative stress in alternated DNA of gastric cells through cytotoxicity.
According to the Canadian cancer society, in 2017(6), an estimated:
* 3,500 Canadians were diagnosed with stomach cancer.
* 2,100 Canadians died from stomach cancer.
* 2,200 men were diagnosed with stomach cancer and 1,250 died from it.
* 1,300 women were diagnosed with stomach cancer and 790 died from it.
Andrographis paniculata is also known as Andrographis is a herbaceous plant, genus Andrographis, belonging to the family Acanthaceae, native to India and Sri Lanka.
The herb has been used in traditional Siddha and Ayurvedic for treatment of common cold, flu, upper respiratory infections, infectious diseases, diarrhea, dysentery, cholera, pneumonia,...
According to the joint study lead by the Chosun University, Andrographolide, a natural compound isolated from Andrographis paniculata, exerted a potentiated apoptosis and reduction of the ability of a cell to form clones triggered by recombinant human tumor necrosis factor of signaling systemic inflammation involved immune stimulation.
The study also found that Andrographolide enhances TRAIL(a protein functioning as a ligand in regulated the process of cell death)-induced apoptosis through interfering cell division via a protein functioning involved the process of cell death and ROS generation in gastric cancer.
Dr. Lim SC, the lead author said, "Exposure of GC cells to andrographolide altered the expression level of several growth-inhibiting and apoptosis-regulating proteins, including death receptors".
In three gastric cancer cell lines (SGC7901, MGC803, BGC823), with Application of Andrographis significantly decreased gastric cancer cells adherence to stimulated endothelial cells by inhibited the E-selectin expression that activated cytokines of the immune system.
Taking all together, Andrographis paniculata with high levels of Andrographolide may be used as a therapeutically promising product in reducing risk and treatment of gastric cancer.
However, further data collection on large sample size and multi-center clinical studies performed with human consumption during the course of the investigation will be necessary to complete the picture of Andrographis and its bioactive compounds protective effect against gastric cancer possibilities.
Intake of Andrographis paniculata supplement should be taken with exceptional care as overdoses may cause acute liver toxicity.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) [Advances in study on the anti-tumor mechanism of andrographolide].[Article in Chinese] by Qi CL1, Wang LJ, Zhou XL. (PubMed)
(2) Andrographolide induces apoptotic and non-apoptotic death and enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in gastric cancer cells by Lim SC1, Jeon HJ1, Kee KH1, Lee MJ1, Hong R1, Han SI2(PubMed)
(3) Andrographolide inhibits the adhesion of gastric cancer cells to endothelial cells by blocking E-selectin expression by Jiang CG1, Li JB, Liu FR, Wu T, Yu M, Xu HM. (PubMed)
(4) Stomach cancer by Mayo Clinic
(5) [Microorganisms and cancer: scientific evidence and new hypotheses].[Article in Spanish] by Velázquez E1, Peix A, Gómez-Alonso A(PubMed)
(6) Stomach cancer statistics (Canadian cancer society)
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