Obesity is a medical condition of excess body fat accumulated overtime. A person is considered an obese if excess body weight relatively to the height is over 30 in BMI index.
According to the University of the Punjab, Epigallocatechin gallate, a polyphenol found in tea plants exhibited anti obesity effect through modulation of thePPAR[gamma] pathway in metabolism involved fat cells/adipose tissues.
In animal study, the chemical constituent stopped the adipogenic cell differentiation through different proteins and transcription factors in expression of adipocyte formation which is considered as fat cell development in contribution to obesity.
Dr. Javaid MS, the lead author in the study said, "Docking analysis of PPAR gamma and epigallocatechin gallate demonstrated that epigallocatechin gallate binds with PPAR gamma at its active site and blocks its activity".
Also, in animal induced by high fat diet, green tea Epigallocatechin 3-gallate (EGCG),exerted anti obesity effects through reduced plasma glucose and alleviate complications of diabetes by attenuating advanced glycation end products (AGEs) formation involved proteins or lipids expression.
Dietary EGCG tested in C57BL/6 mice induced by high-fat diet with or without ECGC for 17 weeks and compared to a control group placed on low-fat diet for the same period, also showed a significanty reduced weight gain, plasma glucose, insulin level, liver and kidney weight, which can be seen in obesity in compared control mice.
Importantly, green tea Epigallocatechin 3-gallate (EGCG fed mice novally decreased the levels of AGEs(advanced glycation end product) in both plasma and liver while inhibiting the receptor for AGE (RAGE) expression of activating Nrf2, antioxidant response and enhanced anti oxidative stress ratio of GSH/GSSG.
Other searchers opinionated the effect of green tea in reduced fat/adipose tissues accumulation in obese subject is a result of the pro-oxidant action of EGCG, in de activated cellular production of reactive oxygen species, through indication of adenosine monophosphate-activated protein kinase in suppressed gene and protein expression of enzymes and transcription factors involved in adipogenesis and lipogenesis(fat and adiposed metabolism).
Taking together, green tea with all the phytochemicals may be used as anti obesity functional food to help control hyperglycemia, reduce weight, and alleviate diabetes complications.
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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Epigallocatechin Gallate as an anti-obesity therapeutic compound: an in silico approach for structure-based drug designing by Javaid MS1, Latief N1, Ijaz B1, Ashfaq UA2(PubMed).
(2) Green tea epigallocatechin 3-gallate alleviates hyperglycemia and reduces advanced glycation end products via nrf2 pathway in mice with high fat diet-induced obesity by Sampath C1, Rashid MR1, Sang S2, Ahmedna M3(PubMed)
(3) Beneficial Effects of Tea and the Green Tea Catechin Epigallocatechin-3-gallate on Obesity by Suzuki T1, Pervin M2, Goto S3, Isemura M4, Nakamura Y5.(PubMed)
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