Wednesday, July 31, 2019
Green Tea and Bioactive Saponin In Prevention and Treatment of Lymphoma
Lymphoma is a medical condition characterized by cell growth disorderly and uncontrollably in the lymph nodes. There were 661,996 people living with non-Hodgkin lymphoma in the United States, 2014.
According to the medical literature online, intake of green tea saponin and phenolic may have a strong influence in lymphoma oncogenesis through some certain aspects.
In EL4 cancer cells line, injection of green bioactive saponin stimulated the immunomodulatory activity in inhibited EL4 cell lines through regulated cytokine expression induced by inflammation and mitogen-activated protein kinases (MAPK) signaling pathway involved in a variety of fundamental cellular processes such as proliferation, differentiation, motility, stress response, apoptosis, and survival.
Furthermore, injected saponin also reduced the expression of EL4 cells line in tumor proliferation by interrupting the process of sequence of mutated DNA transcript in mRNA expression in transmitting transcript by initiating production of inflammatory cytokines to reverse transcription-polymerase chain reaction in making copies of alternated gene, thus attenuating risk of tumor growth, tumor progression and immuno-suppression, activities in host anti-tumor response.
Treatment of green tea saponin also was found to induced cytotoxicity to EL4 cancer cell line without causing harm to healthy cells.
Additionally, the efficacy of tea saponin in inhibition of the proliferation and invasiveness of T-lymphoma (EL4) cells, may be also attributed to the effect of others inflammatory cytokines such as tumor necrosis factor-alpha TNF-α in induced cancer cells death and NF-κB in controlled transcription of DNA, cytokine production and cell survival through mediated the regulation of MAPK pathway in transduction (process by which foreign DNA is introduced into a cell by a virus or viral vector) and extracellular signals to cellular responses in induction of cell proliferation, differentiation, development, transformation, and apoptosis.
Tumor necrosis factor-alpha TNF-α, a pro-inflammatory cytokine plays an important role in the acute phase of inflammation with function in the regulation of biological processes including cell proliferation, differentiation, and apoptosis.
Nuclear factor-κB (NF-κB) is a transcription factor with function in the regulated expression of genes involving many biological processes including innate and adaptive immunity, inflammation and stress responses,
In NOD/SCID mice transplanted intraperitoneally with human non-Hodgkin's lymphoma (NHL) cell lines Namalwa, RAP1-EIO and HS-Sultan, injection of green tea displayed significant inhibition of
50% of Namalwa tumors and RAP1-EIO and HS-Sultan tumor through paralyzed tumor invasive activities.
In compared to chemotherapy drug cyclophosphamide, green tea exhibited anti-angiogenic effect in induction of.frequency of apoptotic endothelial and tumor cell and promoted tumor shrinking by blocking the formation of new blood vessels in providing nutrients and fluid for tumor expansion.
Base on the information findings, researchers opinionated, "Further trials in NHL to evaluate whether green tea, alone or in combination with chemotherapy, may delay or prevent disease progression".
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Immunomodulatory effect of tea saponin in immune T-cells and T-lymphoma cells via regulation of Th1, Th2 immune response and MAPK/ERK2 signaling pathway by Bhardwaj J1, Chaudhary N, Seo HJ, Kim MY, Shin TS, Kim JD.(PubMed)
(2) Inhibition of angiogenesis and induction of endothelial and tumor cell apoptosis by green tea in animal models of human high-grade non-Hodgkin's lymphoma by Bertolini F1, Fusetti L, Rabascio C, Cinieri S, Martinelli G, Pruneri G.(PubMed)
Herbal Turmeric the Natural Prevention and treatment of Cholecystitis
Cholecystitis is the most common condition caused by the gallbladder stones blockage of the cystic duct, which carries bile from the gallbladder, leading to the inflammation of the gallbladder.
Most common symptoms of cholecystitis are severe pain in your upper right or center abdomen, pain that spreads to your right shoulder or back and tenderness over your abdomen when it's touched.
Some patients may also experience symptoms of nausea, vomiting, and fever due to inflammation.
Cholecystitis can be classified into
* Acute cholecystitis is an inflammation of gallbladders that occurs within hours caused by the obstruction of the stone in the bile duct. Calculous cholecystitis is the most common, and less serious, type of acute cholecystitis. accounting 95% of all cases.
* Chronic cholecystitis is a gallbladder inflammation caused by blockage of gallstone that lasts longer than 12 weeks. Most cases of chronic cholecystitis are associated with prior episodes of acute cholecystitis.
Most common risk factors associated with chronic are cholecystitis, infection of the bile duct drainage system, bile duct blockage and excessive cholesterol in the gallbladder that facilitates the onset of gallstone, and decreased blood supply to the gallbladder due to diabetes.
Conventionally, treatment of chronic cholecystitis totally depending on the severity of the condition such as antibiotics for the infection, medicine to dissolve gallstones and pain relief and surgery.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a natural compound for the treatment of cholecystitis, researchers examined the effect of turmeric on cholestasis, a clinically significant symptom and widely associated with liver diseases.
Danning tablet (DNT, a Chinese patent medicine preparation) selected to the study has been clinically used to treat human liver and gallbladder diseases for more than 20 years in China, not only showed significant benefits for the treatment for patients with cholecystitis after cholecystectomy surgery, clinically but also showed protective effect against alpha-naphthylisothiocyanate (ANIT)-induced cholestasis model in rodent.
Additional differentiation of the efficacy of DNT in patients with cholecystitis, researchers found that curcumin, the major compound derived from DNT, demonstrated the protective effect against cholestasis through farnesoid X receptor (FXR), which plays a pivotal role in regulating bile acid, lipid, and glucose homeostasis.
Furthermore, curcumin also inhibited the production of pro-inflammatory cytokines that cause gallbladder inflammation by restoring the bile acid homeostasis.
In other words, curcumin protected the gallbladder against the onset of cholecystitis by inhibiting the proteins and signaling pathways in the activation of inflammation of the gallbladder tissues.
Based on the findings, researchers wrote, "Collectively, curcumin can be served as a potential treatment option for liver injury with cholestasis".
Taken altogether, turmeric processed abundantly n=bioactive compound may be used alone or combined with other remedies for the prevention and treatment of cholecystitis, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin protects ANIT-induced cholestasis through signaling pathway of FXR-regulated bile acid and inflammation by Fan Yang,1,* Xiaowen Tang,1,* Lili Ding,1 Yue zhou,1 Qiaoling Yang,1 Junting Gong,1Guangyun Wang,1 Zhengtao Wang,a,1 and Li Yang. (PMC)
(2) Therapeutic roles of curcumin: lessons learned from clinical trials by Gupta SC1, Patchva S, Aggarwal BB. (PubMed)
Most common symptoms of cholecystitis are severe pain in your upper right or center abdomen, pain that spreads to your right shoulder or back and tenderness over your abdomen when it's touched.
Some patients may also experience symptoms of nausea, vomiting, and fever due to inflammation.
Cholecystitis can be classified into
* Acute cholecystitis is an inflammation of gallbladders that occurs within hours caused by the obstruction of the stone in the bile duct. Calculous cholecystitis is the most common, and less serious, type of acute cholecystitis. accounting 95% of all cases.
* Chronic cholecystitis is a gallbladder inflammation caused by blockage of gallstone that lasts longer than 12 weeks. Most cases of chronic cholecystitis are associated with prior episodes of acute cholecystitis.
Most common risk factors associated with chronic are cholecystitis, infection of the bile duct drainage system, bile duct blockage and excessive cholesterol in the gallbladder that facilitates the onset of gallstone, and decreased blood supply to the gallbladder due to diabetes.
Conventionally, treatment of chronic cholecystitis totally depending on the severity of the condition such as antibiotics for the infection, medicine to dissolve gallstones and pain relief and surgery.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
On finding a natural compound for the treatment of cholecystitis, researchers examined the effect of turmeric on cholestasis, a clinically significant symptom and widely associated with liver diseases.
Danning tablet (DNT, a Chinese patent medicine preparation) selected to the study has been clinically used to treat human liver and gallbladder diseases for more than 20 years in China, not only showed significant benefits for the treatment for patients with cholecystitis after cholecystectomy surgery, clinically but also showed protective effect against alpha-naphthylisothiocyanate (ANIT)-induced cholestasis model in rodent.
Additional differentiation of the efficacy of DNT in patients with cholecystitis, researchers found that curcumin, the major compound derived from DNT, demonstrated the protective effect against cholestasis through farnesoid X receptor (FXR), which plays a pivotal role in regulating bile acid, lipid, and glucose homeostasis.
Furthermore, curcumin also inhibited the production of pro-inflammatory cytokines that cause gallbladder inflammation by restoring the bile acid homeostasis.
In other words, curcumin protected the gallbladder against the onset of cholecystitis by inhibiting the proteins and signaling pathways in the activation of inflammation of the gallbladder tissues.
Based on the findings, researchers wrote, "Collectively, curcumin can be served as a potential treatment option for liver injury with cholestasis".
Taken altogether, turmeric processed abundantly n=bioactive compound may be used alone or combined with other remedies for the prevention and treatment of cholecystitis, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Curcumin protects ANIT-induced cholestasis through signaling pathway of FXR-regulated bile acid and inflammation by Fan Yang,1,* Xiaowen Tang,1,* Lili Ding,1 Yue zhou,1 Qiaoling Yang,1 Junting Gong,1Guangyun Wang,1 Zhengtao Wang,a,1 and Li Yang. (PMC)
(2) Therapeutic roles of curcumin: lessons learned from clinical trials by Gupta SC1, Patchva S, Aggarwal BB. (PubMed)
Tuesday, July 30, 2019
Green Tea and Green Tea Epigallocatechin‑3-O-gallate (EGCG) In Ameliorated Risk and Treatment of Leukemia
Leukemia is a malignant progressive disease characterized by irregular cell growth in the bone marrow and other blood-forming organs. According to the statistic, approximately Over 300 children with 0-14 years of age are diagnosed with leukemia each year in Canada alone.
In the review of the literature published online, green extract epigallocatechin‑3-O-gallate (EGCG) processed a significant anti-cancer effect in reduced chronic myeloid leukemia (CML) expansion in the myeloid cells through numbers of mechanisms.
Application of green tea epigallocatechin‑3-O-gallate (EGCG) in reduced risk of chronic myeloid leukemia (CML) was found to associate to the cellular process of cyclic guanosine monophosphate (cGMP)-dependent pathway and protein kinase Cδ expression to induce cancer cells apoptosis by increased acid sphingomyelinase (ASM) and lipid raft clustering in CML cells.
Acid sphingomyelinase (ASM), an enzyme plays an important role in normal membrane turnover.
Protein kinase Cδ expression plays a key role in signal transduction and are involved in the regulation of numerous cellular processes.
Cyclic guanosine monophosphate (cGMP)-is an important second messenger in many biological processes involved a series of molecular functions.
Further analysis also suggested that exhibited sGC function by injection of green tea EGCG may be an ideal approach to suppresses proliferation and survival of human CML
In other words, reduced expression of regulation of sGC caused by decreased NO production may initiate growth and survival advantage in CML tumor cells.
Soluble guanylyl cyclase (sGC) is the only known receptor for nitric oxide.
Pharmacologically, pretreatment of soluble guanylate cyclase inhibitor NS-2028 decreased nitric oxide (NO)-stimulated sGC activity also reduced green tea polyphenol activities in activated sphingomyelinase (ASM) production.
NS-2028 is a specific inhibitor of soluble guanylyl cyclase.
In acute promyelocytic leukemia (APL), green tea (Camellia sinensis) catechin epigallocatechin-3-gallate (EGCG) displayed a strong and positive effect in elevating the expression of genes associated with cell cycle arrest and differentiation, including gene expression p27, PCAF, C/EBPα, and C/EBPɛ
P27, a cyclin-dependent kinase inhibitor 1B is an enzyme inhibitor and in elevation exerted positive regulation of cancer activity at the G1/S phase transition in cell division.
P300/CBP-associated factor (PCAF), is gene associated in binding to many sequence-specific factors involved in cell growth and/or differentiation.
Enhancer binding protein alphas/EBPα, with function in modulating the expression of genes involved in cell cycle regulation.
Enhancer binding protein epsilon (C/EBPɛ) is a protein composed of two polypeptide chains with function in binding to certain DNA regulatory regions.
Additionally, injection of EGCG also demonstrated a hugh effect against cancerous changes in gene expression and reduced expression of epigenetic modifiers DNMT1, HDAC1, HDAC2, and G9a.
DNA Methyltransferase, (DNMT1), Methylation of DNA is an important component of mammalian epigenetic gene regulation.
Histone deacetylase 1and 2 (HDAC1 and 2) are enzymes promote epigenetic repression and with function in transcriptional regulation, cell cycle progression and development.
Euchromatic histone-lysine N-methyltransferase 2 (EHMT2) or G9a.is epigenetic modifier enzymes with function in regulating gene expression involved the functional role of cancer initiation and progression. Downregulation of G9a also decreased expression of histone H3K9 (H3K9me2) is inhibited cancer cells proliferation
Other, in the multicenter case-control study conducted in China, 2008-2013, comprising 442 incident, hematologically confirmed adult leukemia cases and 442 outpatient controls, individually matched to cases by gender, birth quinquennium by the University of Western Australia also confirmed the inverse association of green tea intake to adult leukemia risk.
Risk of leukemia adjusted odds ratios of 0.50 was found in green tea drinkers in compared to nondrinker, particularly in patients with GSTM1 and GSTP1 genotypes.
Dr. Liu P, the lead author said, "regular daily green tea consumption may reduce leukemia risk in Chinese adults regardless of GSTM1 and GSTP1 polymorphic status. The association between green tea and adult leukemia risk varied with GSTT1 genotype".
Taking all together, green tea and epigallocatechin‑3-O-gallate (EGCG) intake may be considered as a secondary therapeutic application combined with standard therapy for the treatment of Leukemia regardless of polymorphic status.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Green tea polyphenol epigallocatechin-O-gallate induces cell death by acid sphingomyelinase activation in chronic myeloid leukemia cells.by Huang Y1, Kumazoe M1, Bae J1, Yamada S1, Takai M1, Hidaka S1, Yamashita S1, Kim Y1, Won Y1, Murata M1, Tsukamoto S1, Tachibana H1.(PubMed)
(2) Green tea polyphenol EGCG causes anti-cancerous epigenetic modulations in acute promyelocytic leukemia cells by Borutinskaitė V1, Virkšaitė A1, Gudelytė G1, Navakauskienė R1.(PubMed)
(3) Green tea consumption and glutathione S-transferases genetic polymorphisms on the risk of adult leukemia by Liu P1, Zhang M2,3, Xie X4, Jin J5, Holman CD2.(PubMed)
Whole Food Tomato Promote the Ratio of Gut Microbiota For Optimal Health
Gut Microbiota is a community of microorganisms living in the gastrointestinal tract.
Under normal conditions, gut microbiota plays a critical role in overall health, including the impacts of
* In nutrient metabolism, gut microbiota improves the absorption of the dietary nutrients of the digestive system
* In xenobiotic and drug metabolism, gut microbiota protects the body against xenobiotics and drug toxicity through facilitating the excretion.
* Maintenance of the structural integrity of the gut mucosal barrier, gut microbiota enhances the epithelial cells with a function to protect the intestine against invasive pathogens and ensure the function of intestinal in nutrients adsorption.
* In immunomodulation, gut microbiota interact with the immune system against inflammatory immune disorders and inhibits the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.
However, imbalanced of the ratio of gut microbiota may have a negative on human health and diseases.
Dr. Yu-Jie Zhang wrote, "Gut bacteria are an important component of the microbiota ecosystem in the human gut, which is colonized by 1014 microbes, ten times more than the human cells. Gut bacteria play an important role in human health, such as supplying essential nutrients, synthesizing vitamin K, aiding in the digestion of cellulose, and promoting angiogenesis and enteric nerve function".
And, "However, they can also be potentially harmful due to the change of their composition when the gut ecosystem undergoes abnormal changes in the light of the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle. Dysbiosis of the gut bacteria communities can cause many chronic diseases, such as inflammatory bowel disease, obesity, cancer, and autism".
Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
In the urgency to discover healthy foods for enhancing the ratio of dut microbiota composition researchers examined the effect of consuming tomato products and lycopene on chronic inflammatory disorders associated with intestinal bacteria in an animal model.
The study included Winnie mice as a model of spontaneous ulcerative colitis treated with or without chow enriched with 1% Bronze tomato.
At week 2, the Bronze-enriched chow treated group showed no macroscopic effect on the IBD symptoms.
However, levels of pro-inflammatory cytokines found in the treated mice were significantly reduced, observed by the levels of IL17A and IFNγ.
According to the analysis of the microbial composition, two weeks of Bronze enriched diet demonstrated a strong effect in the improvement of the gut microbiota ratio in the tested mice.
Additional differentiation of the results, researchers found that the efficacy of Bronze tomato in promotion of gut health was attributed to the phytochemical polyphenols presented in the tomato.
Taken altogether, tomato processed a high amount of lycopene may be considered a dietary supplements for the gut health, pending to large sample size and multicenter human study.
Intake of polyphenols in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The impact of tomato fruits containing multi-walled carbon nanotube residues on human intestinal epithelial cell barrier function and intestinal microbiome composition by Lahiani MH 1, Khare S, Cerniglia CE, Boy R, Ivanov IN, Khodakovskaya M. (PubMed)
(2) A Bronze-Tomato Enriched Diet Affects the Intestinal Microbiome under Homeostatic and Inflammatory Conditions.
Liso M1, De Santis S2, Scarano A3, Verna G4, Dicarlo M5, Galleggiante V6, Campiglia P7, Mastronardi M8, Lippolis A9, Vacca M10, Sobolewski A11, Serino G12, Butelli E13, De Angelis M14, Martin C15, Santino A16, Chieppa M. (PubMed)
(3) Impacts of Gut Bacteria on Human Health and Diseases by Yu-Jie Zhang,1 Sha Li,2 Ren-You Gan,3 Tong Zhou,1 Dong-Ping Xu,1 and Hua-Bin Li. (PMC)
Under normal conditions, gut microbiota plays a critical role in overall health, including the impacts of
* In nutrient metabolism, gut microbiota improves the absorption of the dietary nutrients of the digestive system
* In xenobiotic and drug metabolism, gut microbiota protects the body against xenobiotics and drug toxicity through facilitating the excretion.
* Maintenance of the structural integrity of the gut mucosal barrier, gut microbiota enhances the epithelial cells with a function to protect the intestine against invasive pathogens and ensure the function of intestinal in nutrients adsorption.
* In immunomodulation, gut microbiota interact with the immune system against inflammatory immune disorders and inhibits the risk of gastrointestinal diseases and non-gastrointestinal diseases caused by overexpression of bad bacteria.
However, imbalanced of the ratio of gut microbiota may have a negative on human health and diseases.
Dr. Yu-Jie Zhang wrote, "Gut bacteria are an important component of the microbiota ecosystem in the human gut, which is colonized by 1014 microbes, ten times more than the human cells. Gut bacteria play an important role in human health, such as supplying essential nutrients, synthesizing vitamin K, aiding in the digestion of cellulose, and promoting angiogenesis and enteric nerve function".
And, "However, they can also be potentially harmful due to the change of their composition when the gut ecosystem undergoes abnormal changes in the light of the use of antibiotics, illness, stress, aging, bad dietary habits, and lifestyle. Dysbiosis of the gut bacteria communities can cause many chronic diseases, such as inflammatory bowel disease, obesity, cancer, and autism".
Tomato is red, edible fruit, genus Solanum, belonging to family Solanaceae, native to South America. Because of its health benefits, the tomato is grown worldwide for the commercial purpose
and often in the greenhouse.
In the urgency to discover healthy foods for enhancing the ratio of dut microbiota composition researchers examined the effect of consuming tomato products and lycopene on chronic inflammatory disorders associated with intestinal bacteria in an animal model.
The study included Winnie mice as a model of spontaneous ulcerative colitis treated with or without chow enriched with 1% Bronze tomato.
At week 2, the Bronze-enriched chow treated group showed no macroscopic effect on the IBD symptoms.
However, levels of pro-inflammatory cytokines found in the treated mice were significantly reduced, observed by the levels of IL17A and IFNγ.
According to the analysis of the microbial composition, two weeks of Bronze enriched diet demonstrated a strong effect in the improvement of the gut microbiota ratio in the tested mice.
Additional differentiation of the results, researchers found that the efficacy of Bronze tomato in promotion of gut health was attributed to the phytochemical polyphenols presented in the tomato.
Taken altogether, tomato processed a high amount of lycopene may be considered a dietary supplements for the gut health, pending to large sample size and multicenter human study.
Intake of polyphenols in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The impact of tomato fruits containing multi-walled carbon nanotube residues on human intestinal epithelial cell barrier function and intestinal microbiome composition by Lahiani MH 1, Khare S, Cerniglia CE, Boy R, Ivanov IN, Khodakovskaya M. (PubMed)
(2) A Bronze-Tomato Enriched Diet Affects the Intestinal Microbiome under Homeostatic and Inflammatory Conditions.
Liso M1, De Santis S2, Scarano A3, Verna G4, Dicarlo M5, Galleggiante V6, Campiglia P7, Mastronardi M8, Lippolis A9, Vacca M10, Sobolewski A11, Serino G12, Butelli E13, De Angelis M14, Martin C15, Santino A16, Chieppa M. (PubMed)
(3) Impacts of Gut Bacteria on Human Health and Diseases by Yu-Jie Zhang,1 Sha Li,2 Ren-You Gan,3 Tong Zhou,1 Dong-Ping Xu,1 and Hua-Bin Li. (PMC)
Monday, July 29, 2019
Green Tea and Its polyphenol (-)-epigallocatechin-3-gallate EGCG in Ameliorated Risk and Treatment of Endometrial Cancer
Endometrial cancer is a medical condition characterized by cell growth uncontrollably in the endometrium. At the late stage, the cancerous cell may travel a distance away from the original site to infect other organs and tissues.
In the review of researcher papers online, the effects of green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) in inhibition of endometrial cancer was expressed in various aspects.
In the experiment of green tea bioactive compound against the progression of tumor xenografts of human endometrial cancer, (-)-epigallocatechin-3-gallate EGCG demonstrated a significant effect in reduced risk of endometrial cancer development through the bioactive chemicals anti-tumor angiogenesis properties.
In fact, the anti-cancer active compound efficacy was attributed to the modulation of expression of vascular endothelial growth factor A (VEGFA) protein in the established new vessel to stimulate the onset of cancer and cancer cell proliferation and HIF-1 functions in activated transcription of many genes, in regulated cellular and systemic homeostatic response to external changes to tumor growth.
Furthermore, application of EGCG also suppressed responses of chemokine (C-X-C motif) ligand 12 (CXCL12) in expression of multiple physiological processes, in promoted invasion and metastasis of tumor cells in connected tissues of the uterine mucosa (endometrium), thus reducing the infiltration of VEGFA-expressing tumor-associated macrophages (TAMs) in supplying rapidly growing malignant tissues with essential nutrients and oxygen.
Additionally, further analysis also insisted that EGCG restricted secretion of vascular endothelial growth factor A (VEGFA) is initiated endometrial cancer growth by inhibiting the function of PI3K/AKT/mTOR/HIF1α pathway in regulated many cellular processes, including cell survival, proliferation, and growth.
After taking account of all findings, treatment with EGCG reduced risk of endometrial cancer onset may be results of EGCG suppressed secretion in both fronts including decreased cancer cell-secreted VEGFA but inhibited TAM-secreted VEGFA in endometrial cancer progression.
Further differentiation, also showed that green tea polyphenol (-)-epigallocatechin-3-gallate reduced cancer expansion by suppressing the expression of proliferation markers which acts indirectly to stimulate endometrial epithelial proliferation in estrogen receptor α, progesterone receptor, proliferating cell nuclear antigen and cyclin D1
The overexpression of cyclin D1 has been linked to the development and progression of cancer.
Proliferating cell nuclear antigen is a protein with function in cell cycle regulation and/or DNA replication and important for both DNA synthesis and DNA repair.
Importantly, the inhibition of EGCG also decreased the activation of ERK, the extracellular signal-regulated kinases protein in cancer cell division and down-expression of transcription factors fos and jun, the cellular immediate-early genes in induced transient cancer cell division and differentiation processes.
The function of EGCG in reduced risk of endometrial cancer also expressed through Bcl-2-associated X protein, cleavage of caspase-3 and poly(ADP-ribose) polymerase actions in induction of cancer cell apoptosis and suppression of antiapoptotic protein Bcl-2 (B-cell lymphoma 2).
Bcl-2-associated X is a protein with function of anti- or pro-apoptotic regulators involved in a wide variety of cellular activities.
B-cell lymphoma 2, a family protein with function in the regulation of cell apoptosis.
Cleavage of caspase-3 also is known as a critical executioner of apoptosis,
Poly(ADP-ribose) polymerase is a protein with function involved in a number of cellular processes, including programmed cell death.
Implicitly, application of EGCG also increased the production of free radical expression in initiated the cytotoxicity effect by reduced levels of antioxidant glutathione levels and activated the p38 in cancer cells death without inducing toxicity to normal cells
P38 mitogen-activated protein kinases (MAPKs) are activated by a wide range of cellular stresses as well as in response to inflammatory cytokines involved in cell differentiation, apoptosis, and autophagy.
Indeed, according to a systematic review of literature published on database of PubMed, Embase, Cochrane Library and China Biological Medicine Database upto February 2, 2015 , researchers indicated that green tea consumption was associated with a reduced risk of EC with a relative risk of .78 and each additional cup of green tea consumed per day decreased risk of developing EC by 11%.
Particularly, the intake of green tea associated with attenuated risk of endometrial cancer was 84.33% in compared to 5.07 % of black tea.
Taken together, green tea and its polyphenol (-)-epigallocatechin-3-gallate EGCG may be considered a functional food used conjunction with standard therapy in reduced risk and treatment of endometrial cancer.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Green tea, black tea consumption and risk of endometrial cancer: a systematic review and meta-analysis by Zhou Q1, Li H2, Zhou JG3, Ma Y4, Wu T5, Ma H6.(PubMed)
(2) A prodrug of green tea polyphenol (-)-epigallocatechin-3-gallate (Pro-EGCG) serves as a novel angiogenesis inhibitor in endometrial cancer by Wang J1, Man GCW2, Chan TH3, Kwong J1, Wang CC4.(PubMed)
(3) (-)-Epigallocatechin-3-gallate induces apoptosis in human endometrial adenocarcinoma cells via ROS generation and p38 MAP kinase activation by Manohar M1, Fatima I, Saxena R, Chandra V, Sankhwar PL, Dwivedi A.(PubMed)
Onion Blocks the Initiation of Prostate Cancer
The prostate warped around a tube (the urethra) is a gland of the male reproductive system found in front of the rectum and just below the bladder and responsible for making some of the semen that carries sperm.
The prostate gland is considered a reproductive organ in men.
Prostate cancer is a medical condition caused by cell growth disorderly in the prostate tissue due to the alternation of DNA.
At the advanced stage, the cancerous cell in the prostate can spread to the distance away to inject other healthy tissue and organ, leading to a secondary metastasis through lymph and blood.
Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during the physical (rectum) exams.
According to the statistics provided by the American Cancer Society, approximately 174,650 cases of prostate cancer will be diagnosed in 2019. Prostate cancer will cause the death of 31620 Americans.
The exact causes of prostate cancer are not known. However, epidemiologically, below are some of the most prevalent factors associated with prostate cancer risk
*Age
The risk of developing prostate cancer increases with the age of over 45
* Family history
Statistic showed that if one of your directed family members has prostate cancer, you are twice at risk to develop it as well.
*Race
Prostate cancer is more likely to strike black and white or Hispanic men in the US.
* Heredity
Certain genes mutation is associated in promoting the growth of prostate cancer, including hereditary prostate cancer gene 1 (HPC1), transmembrane protease, serine 2-ERG or transmembrane protease, serine 2-ETV1/4, etc.
Researchers found that up to 70 percent of men with prostate cancer have lost one copy of the Phosphatase and tensin homolog (PTEN) gene at the time of diagnosis. The tumor protein 53
(p53) mutations are a late event in pathology of prostate cancer.
* Low levels of vitamin D in the blood
Researchers found that men with a deficiency of level of vitamin D in the blood are at higher risk to develop prostate cancer.
* Excessive drinking
Excessive drink not only increases the risk of liver cancer but also associated with a higher risk of prostate cancer as it interferes with folate metabolism. Risk of prostate cancer is much high for men with excessive drinking habit and folate deficiency.
* Enlarged prostate
Men with an enlarged prostate are at high risk in developing prostate cancer.
* Sexual transmitting diseases
Infected diseases such as chlamydia, gonorrhea, or syphilis are associated with a higher risk of the diseases.
*Obesity
In a study of Obesity May Raise Risk of Prostate Cancer Spread, Christopher J. Keto, MD, a urological oncology postdoctoral associate at Duke University Medical Center, Durham, N.C. found that overweight men were three times more likely to have their cancer spread.
The onion is a plant in the genus Allium, belongings to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
With an aim to find a potential compound for the promotion of prostate health, researchers examined the effect of onion on prostate cancer in vivo and vitro.
According to a population-based case-control study in Shanghai, Hsing et. al. participants in the highest of 3 intake categories of total Allium vegetables, including onion showed a significant effect in reducing the risk of prostate cancer with the relative odds ratio risk of .53 compared to those with the lowest intake.
In the Italian and Swiss case-control networks study, researchers surprisingly showed that participants with the highest intake of both onions do not have significantly decreased OR of prostate cancer compared to those with the lowest intake, However, according to the differentiation, there was evidence of a trend of decreased odds with increasing intake.
In other words, over time, increased intake of onion may have significant activity in reducing the prostate cancer risk.
The results strongly suggested, over time, regular consumption may decrease the risk of prostate cancer, depending on the amount of onion intake daily.
Taken altogether, onion used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of adjuvant rheumatic diseases, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Garlic and onions: Their cancer prevention properties by Holly L. Nicastro,1 Sharon A. Ross,2 and John A. Milner. (PubMed)
(2) Prostate Cancer by Kyle J. Norton
The prostate gland is considered a reproductive organ in men.
Prostate cancer is a medical condition caused by cell growth disorderly in the prostate tissue due to the alternation of DNA.
At the advanced stage, the cancerous cell in the prostate can spread to the distance away to inject other healthy tissue and organ, leading to a secondary metastasis through lymph and blood.
Most prostate cancers are slow growing and enlarged prostate and prostate cancer may be detected during the physical (rectum) exams.
According to the statistics provided by the American Cancer Society, approximately 174,650 cases of prostate cancer will be diagnosed in 2019. Prostate cancer will cause the death of 31620 Americans.
The exact causes of prostate cancer are not known. However, epidemiologically, below are some of the most prevalent factors associated with prostate cancer risk
*Age
The risk of developing prostate cancer increases with the age of over 45
* Family history
Statistic showed that if one of your directed family members has prostate cancer, you are twice at risk to develop it as well.
*Race
Prostate cancer is more likely to strike black and white or Hispanic men in the US.
* Heredity
Certain genes mutation is associated in promoting the growth of prostate cancer, including hereditary prostate cancer gene 1 (HPC1), transmembrane protease, serine 2-ERG or transmembrane protease, serine 2-ETV1/4, etc.
Researchers found that up to 70 percent of men with prostate cancer have lost one copy of the Phosphatase and tensin homolog (PTEN) gene at the time of diagnosis. The tumor protein 53
(p53) mutations are a late event in pathology of prostate cancer.
* Low levels of vitamin D in the blood
Researchers found that men with a deficiency of level of vitamin D in the blood are at higher risk to develop prostate cancer.
* Excessive drinking
Excessive drink not only increases the risk of liver cancer but also associated with a higher risk of prostate cancer as it interferes with folate metabolism. Risk of prostate cancer is much high for men with excessive drinking habit and folate deficiency.
* Enlarged prostate
Men with an enlarged prostate are at high risk in developing prostate cancer.
* Sexual transmitting diseases
Infected diseases such as chlamydia, gonorrhea, or syphilis are associated with a higher risk of the diseases.
*Obesity
In a study of Obesity May Raise Risk of Prostate Cancer Spread, Christopher J. Keto, MD, a urological oncology postdoctoral associate at Duke University Medical Center, Durham, N.C. found that overweight men were three times more likely to have their cancer spread.
The onion is a plant in the genus Allium, belongings to the family Alliaceae, a close relation of garlic. It is often called the "king of vegetables" because of its pungent taste and found in a large number of recipes and preparations spanning almost the totality of the world's cultures.
Depending on the variety, an onion can be sharp, spicy, tangy, pungent, mild or sweet.
With an aim to find a potential compound for the promotion of prostate health, researchers examined the effect of onion on prostate cancer in vivo and vitro.
According to a population-based case-control study in Shanghai, Hsing et. al. participants in the highest of 3 intake categories of total Allium vegetables, including onion showed a significant effect in reducing the risk of prostate cancer with the relative odds ratio risk of .53 compared to those with the lowest intake.
In the Italian and Swiss case-control networks study, researchers surprisingly showed that participants with the highest intake of both onions do not have significantly decreased OR of prostate cancer compared to those with the lowest intake, However, according to the differentiation, there was evidence of a trend of decreased odds with increasing intake.
In other words, over time, increased intake of onion may have significant activity in reducing the prostate cancer risk.
The results strongly suggested, over time, regular consumption may decrease the risk of prostate cancer, depending on the amount of onion intake daily.
Taken altogether, onion used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of adjuvant rheumatic diseases, pending to the confirmation of the larger sample size and multicenter human study.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Garlic and onions: Their cancer prevention properties by Holly L. Nicastro,1 Sharon A. Ross,2 and John A. Milner. (PubMed)
(2) Prostate Cancer by Kyle J. Norton
Sunday, July 28, 2019
Green Tea Polyphenols in Attenuated Risk and Treatment of Bladder Cancer
Bladder cancer is a medical condition characterized by irregular cell growth in the tissues of the bladder. At the later stage, the cancerous cell may travel a distance away to invade other healthy tissues and organs.
According to statistic provided by cancer.net, 90% of people with bladder cancer are older than 55, and the average age of people diagnosed with bladder cancer is 73
In the review of medical literature published online, green tea major catechin EGCG in reduced risk and treatment may be attributed to numbers of mechanisms.
In T24 human bladder cancer cell line, application of the chemopreventive/antiproliferative potential of (-)-epigallocatechin gallate (EGCG, the major phytochemical in green tea) induced anti malignant cell proliferation by modulating the expression of phosphatidylinositol 3' kinase/Akt in the activating Bcl-2 family proteins with function in regulation of cell death, thus enhancing apoptosis of T24 bladder cancer cell line in dose- and time-dependent manner.
The phosphatidylinositol 3'-kinase/AKT pathway is a crucial regulator of cellular processes including cell proliferation and apoptosis.
Bcl-2 family proteins is a modulator responsible for the regulation of cell apoptosis.
In C3H/HeN mice subcutaneously implanted with MBT-2 murine bladder tumor cells, administration of EGCGs physically attached to the surface of nanogold particles pNG(EGCG-adsorbed pNG) exerted a significant anti-cancer proliferation through induction of apoptosis.
This action of anti-cancer effect was attributed to a mechanism of EGCG-pNG in the activation of caspases which plays an important role in induced cell apoptosis and inflammation through Bcl-family proteins with a function in control apoptosis by activating caspase proteases in the governing the space between outer and inner mitochondrial membrane.
Under stress, the mitochondrial pathway or the intrinsic pathway is activated depending on the release of proteins from the intermembrane space of mitochondria.
Caspase cascade, family protease enzymes with function in programmed cell death and inflammation.
Additionally, injecting EGCG-pNG directly into the tumor site inhibited tumor expansion through ameliorated the function of vascular endothelial growth factor (VEGF) in the stimulated formation of a new blood vessel in provided nutrients and oxygen for the survival of cancer site in compared to
oral administration of EGCG in stimulated immune function in suppression of cancer progression.
The vascular endothelial growth factor is a signal protein produced by cells in the stimulated formation of the blood vessel for cell division and site proliferation.
Based on information collected,, the prepared EGCG-pNG was more effective than free EGCG in inhibiting bladder tumor in model mice.
More interestingly, bladder tumor induced by N-butyl-(-4-hydroxybutyl) nitrosamine (BBN) 0.05% solution on 8 week-old female C3H/He mice for 14 or 24 weeks on treatment with or without green tea polyphenols (GTP) expressed a significant lower rate of tumor invasive frequency of 23.8%; in group treated with both GTP and BBN in compared to 65.2% in group treated with BBN alone.
The tumor volume and microvascular density (MVD) as an independent predictor within a tumor and the connective, functionally supportive framework of a biological cell, tissue, or organ region in the BBN+GTP group were also significantly lower than in BBN treated mice.
Unbelievably, green tea polyphenols inhibited tumor growth and invasion in mice with established bladder cancer through regulation of angiogenetic effect in suppressed the forming of the new blood vessel for the tumor cells proliferation, metastatic spread, as well as providing oxygen and nutrients and removal of waste products of cancer cells without exhibiting the anti-carcinogenic effect.
Taken together, green tea extract polyphenols may be considered an adjunct therapy for reduced risk and used a combination with standard medicine for the treatment of bladder cancer.
For More information about yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) A component of green tea, (-)-epigallocatechin-3-gallate, promotes apoptosis in T24 human bladder cancer cells via modulation of the PI3K/Akt pathway and Bcl-2 family proteins by Qin J1, Xie LP, Zheng XY, Wang YB, Bai Y, Shen HF, Li LC, Dahiya R.(PubMed)
(2) The treatment of bladder cancer in a mouse model by epigallocatechin-3-gallate-gold nanoparticles by Hsieh DS1, Wang H, Tan SW, Huang YH, Tsai CY, Yeh MK, Wu CJ.(PubMed)
(3) Green tea polyphenol suppresses tumor invasion and angiogenesis in N-butyl-(-4-hydroxybutyl) nitrosamine-induced bladder cancer by Sagara Y1, Miyata Y, Nomata K, Hayashi T, Kanetake H.(PubMed)
Bromelain Blocks the Onset of Endometriosis
Endometriosis is a medical condition characterized by the growth of endometrial cells somewhere else instead of the inside of the uterus.
More precisely, on the last stage of the menstrual cycle, instead of a layer of endometriosis lining on the inside of the uterus expelled, known as menstruation blood, some of the endometriosis tissues grow somewhere in the body.
Most endometriosis tissues do not travel far. Most cases of endometriosis are diagnosed within the pelvic region, on the lining of peritoneum, in the ovaries, and on the surface of the uterus's an outside wall, however, the condition can also be found anywhere in the body such as well as fallopian tubes, the cervix, the vagina, and even the vulva.
Believe it or not, about
* 20% of reproductive age women with endometriosis present without symptoms.
*55% of women who have developed the new onset of severe menstrual cramps.
* 25% of women with sub-fertility (less fertile than a normal couple)
Endometriosis can be classified into different stages, depending on the severity of the disease
* Minimal stage:
Commonly they are found on the top surface, of the inside wall of uterus, ligaments, and ovary with a few in numbers.
* Mild stage:
Deeper implants, greater numbers are presented. Commonly found in the same area as a minimal stage.
* Moderate stage:
Many implants, endometrial cysts present, affecting ovary function, causing scar tissues and adhesion are also present.
* Severe stage:
Intensive peritoneal implants, large endometromas present and dense adhesion.
Each woman experiences differently to endometriosis. Some women may have extensive endometrial tissues in their body but feel little or no pain at all, compared to other women in the early stage of endometriosis with excessive pain.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding a potential compound for the treatment of endometriosis, researchers evaluated the efficacy of an association of N-acetyl cysteine, alpha-lipoic acid, and bromelain (NAC/LA/Br) in vivo murine model and in vitro human endometriotic endothelial cells (EECs) and on endothelial cells isolated from the normal uterus (UtMECs.
In endometrial cells EECs preincubated with NAC/LA/Br, levels of pro-inflammatory cytokines associated with TNF-α were significant reduced observed by lower expression of the inflammatory "marker" VCAM1.
On human endometriotic cysts intraperitoneally into SCID mice, NAC/LA/Br exerted a strong apoptotic activity against EECs without affecting the endothelial cells isolated from the normal uterus (UtMECs).
Furthermore, compared to untreated mice, mice treated with NAC/LA/Br presented a lower number of cysts, smaller in size.
Based on the findings, researchers said, "these dietary supplements may have potential therapeutic uses in the treatment of chronic inflammatory diseases like endometriosis".
Moreover, in order to reveal more information about NAC/LA/Br on symptoms of endometriosis, researchers examined the effect of N-acetyl cysteine, alpha lipoic acid, and bromelain on endometriosis- pelvic pain.
In a total, 398 patients with a mean age of 34.6 ± 7.2 years, treatment of the combination of N-acetyl cysteine, alpha lipoic acid, and bromelain for 6 months showed a significant improvement in endometriosis-associated pelvic pain compared to the baseline.
More precisely, compared to the baseline of 92.7% of the patients had pain intensity > 4 on the visual analog scale (VAS); treatment of NAC/LA/Br at 3 months decreased the percentage of patients to 87.2% (p = 0.074) and at 6 months to 82.7%, respectively.
Dr. Lete I, the lead scientist said, "Women with endometriosis who wish to become pregnant and are treated with a preparation containing N-acetyl cysteine, alpha lipoic acid and bromelain experienced a significant improvement in endometriosis-associated pelvic pain and required lower intake of rescue analgesics".
Taken altogether, bromelain combined with conventional medicine may be considered a remedy for the prevention and treatment of endometriosis and endometrial symptoms, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effectiveness of an antioxidant preparation with N-acetyl cysteine, alpha lipoic acid and bromelain in the treatment of endometriosis-associated pelvic pain: LEAP study by Lete I1, Mendoza N2, de la Viuda E3, Carmona F. (PubMed)
(2) The combination of N-acetyl cysteine, alpha-lipoic acid, and bromelain shows high anti-inflammatory properties in novel in vivo and in vitro models of endometriosis by Agostinis C1, Zorzet S2, De Leo R1, Zauli G1, De Seta F3, Bulla R. (PubMed)
(3) Endometriosis part I - Definition, Stages, Symptoms, Causes, and Effects Of Endometriosis by Kyle J. Norton
More precisely, on the last stage of the menstrual cycle, instead of a layer of endometriosis lining on the inside of the uterus expelled, known as menstruation blood, some of the endometriosis tissues grow somewhere in the body.
Most endometriosis tissues do not travel far. Most cases of endometriosis are diagnosed within the pelvic region, on the lining of peritoneum, in the ovaries, and on the surface of the uterus's an outside wall, however, the condition can also be found anywhere in the body such as well as fallopian tubes, the cervix, the vagina, and even the vulva.
Believe it or not, about
* 20% of reproductive age women with endometriosis present without symptoms.
*55% of women who have developed the new onset of severe menstrual cramps.
* 25% of women with sub-fertility (less fertile than a normal couple)
Endometriosis can be classified into different stages, depending on the severity of the disease
* Minimal stage:
Commonly they are found on the top surface, of the inside wall of uterus, ligaments, and ovary with a few in numbers.
* Mild stage:
Deeper implants, greater numbers are presented. Commonly found in the same area as a minimal stage.
* Moderate stage:
Many implants, endometrial cysts present, affecting ovary function, causing scar tissues and adhesion are also present.
* Severe stage:
Intensive peritoneal implants, large endometromas present and dense adhesion.
Each woman experiences differently to endometriosis. Some women may have extensive endometrial tissues in their body but feel little or no pain at all, compared to other women in the early stage of endometriosis with excessive pain.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
On finding a potential compound for the treatment of endometriosis, researchers evaluated the efficacy of an association of N-acetyl cysteine, alpha-lipoic acid, and bromelain (NAC/LA/Br) in vivo murine model and in vitro human endometriotic endothelial cells (EECs) and on endothelial cells isolated from the normal uterus (UtMECs.
In endometrial cells EECs preincubated with NAC/LA/Br, levels of pro-inflammatory cytokines associated with TNF-α were significant reduced observed by lower expression of the inflammatory "marker" VCAM1.
On human endometriotic cysts intraperitoneally into SCID mice, NAC/LA/Br exerted a strong apoptotic activity against EECs without affecting the endothelial cells isolated from the normal uterus (UtMECs).
Furthermore, compared to untreated mice, mice treated with NAC/LA/Br presented a lower number of cysts, smaller in size.
Based on the findings, researchers said, "these dietary supplements may have potential therapeutic uses in the treatment of chronic inflammatory diseases like endometriosis".
Moreover, in order to reveal more information about NAC/LA/Br on symptoms of endometriosis, researchers examined the effect of N-acetyl cysteine, alpha lipoic acid, and bromelain on endometriosis- pelvic pain.
In a total, 398 patients with a mean age of 34.6 ± 7.2 years, treatment of the combination of N-acetyl cysteine, alpha lipoic acid, and bromelain for 6 months showed a significant improvement in endometriosis-associated pelvic pain compared to the baseline.
More precisely, compared to the baseline of 92.7% of the patients had pain intensity > 4 on the visual analog scale (VAS); treatment of NAC/LA/Br at 3 months decreased the percentage of patients to 87.2% (p = 0.074) and at 6 months to 82.7%, respectively.
Dr. Lete I, the lead scientist said, "Women with endometriosis who wish to become pregnant and are treated with a preparation containing N-acetyl cysteine, alpha lipoic acid and bromelain experienced a significant improvement in endometriosis-associated pelvic pain and required lower intake of rescue analgesics".
Taken altogether, bromelain combined with conventional medicine may be considered a remedy for the prevention and treatment of endometriosis and endometrial symptoms, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Effectiveness of an antioxidant preparation with N-acetyl cysteine, alpha lipoic acid and bromelain in the treatment of endometriosis-associated pelvic pain: LEAP study by Lete I1, Mendoza N2, de la Viuda E3, Carmona F. (PubMed)
(2) The combination of N-acetyl cysteine, alpha-lipoic acid, and bromelain shows high anti-inflammatory properties in novel in vivo and in vitro models of endometriosis by Agostinis C1, Zorzet S2, De Leo R1, Zauli G1, De Seta F3, Bulla R. (PubMed)
(3) Endometriosis part I - Definition, Stages, Symptoms, Causes, and Effects Of Endometriosis by Kyle J. Norton
Saturday, July 27, 2019
Green Tea Epigallocatechin-3-gallate (EGCG) In Reduced Risk and Treatment of Esophageal Cancer
Esophageal cancer is a medical condition characterized by irregular cell growth in the tissues of the esophagus. At the later stage, the cancerous cells may travel a distance away to invade other healthy tissues and organs.
According to statistic, 2,300 Canadians will be diagnosed with esophageal cancer in 2017.
In the review of the literature published online, green tea efficacy in the treatment of human esophageal squamous cell carcinoma was expressed in a number of mechanisms.
In esophageal cancer cell lines Eca109 and Ec9706, injection of green tea EGCG plus chemo drug adriamycin (ADM) after 24 hours displayed a significantly increased cellular apoptosis.
According to flow cytometry assay, the application induced the elevation of ROS and ADM concentration in the production of toxicity to counter the reaction of tumor cell in diminished expression of mitochondrial membrane potential and ABCG2 protein to induced apoptosis, without harm to healthy cells.
ABCG2 protein expression plays a major role in multi-drug resistance, produced by tumor cells to accounter reaction to chemo-medicine.
The mitochondrial membrane potential is a central intermediate in oxidative energy metabolism, the deceased levels caused by toxicity ROS may result in energy depletion and subsequently, causing cells death.
Further observation also indicated that EGCG inhibited the growth of Eca109 and Ec9706 cells through ameliorated the anti-apoptotic bcl-2 protein expression and promoted Bax and caspase-3 protein expressions with functions in induced apoptosis in a dose- and time-dependent manner.
BCL2 family members form hetero- or homodimers and play an important anti-apoptotic protein.
Caspase-3 protein plays a central role in the execution phase of cell apoptosis.
BAX gene. BAX is a member of the Bcl-2 gene family. plays an important role in the mediation of cell death by apoptosis.
Compared to ADM treatment alone, the Eca109/ABCG2 multi-drug resistance cancer cells, the rate of apoptosis and ADM concentration were significantly higher levels of mitochondrial membrane potential and ABCG2 expression was lower.
In other words, injection of green tea plus ADM was more effective in induced cells death in Eca109/ABCG2 multi-drug resistance cancer cells with expression ROS and ADM in enhanced elevation cytotoxicity activity in compared to ADM treatment alone.
After taking into account others confounders, Dr, Liu L the lead author said, " EGCG inhibited cell growth and induced esophageal cancer cell apoptosis. It reduced the bcl-2 protein expression and increased the bax and caspase-3 protein expression. EGCG reversed multi-drug resistance by reducing ABCG2 expression and increasing the anticancer drug concentration in cancer cells".
In esophageal squamous cell carcinoma, application of Epigallocatechin-3-gallate (EGCG) without ADM measured by flow cytometry assay, after 24 hours also inhibited cancer site proliferation by increased expression of ROS to attenuate mitochondrial membrane potential function in energy metabolism and caspase-3 protein to cause malignant cellular apoptosis, in a dose and time-dependent manner.
In the examine the PCR-TRAP argentation analysis during the experiment, EGCG was also demonstrated to inhibit the viability of Eca109 and Ec9706 cells by suppressing cancer cell in alternated DNA transcript through telomerase activity.
More interestingly, the continuation of study of epigallocatechin-3-gallate (EGCG) on the human esophageal cancer cell line ECa109 also discover that EGCG demonstrated a decrease of cancer cell viability but a substantial rate of apoptosis by increased expression of p16 gene demethylation in induced cancer cell cycle arrest and apoptosis, level p16 mRNA expression in suppressed tumor progression of invasive and aggressive behavior. and p16 protein expression in promoted tumor suppressible activity, in a dose- and time-dependent manner.
P16 gene demethylation plays an important role in cell cycle arrest and apoptosis. gene alternation was found in several types of cancer.
Low level of p16 mRNA expression is associated with the progression of cancer with malignant and aggressive behavior.
Abnormalities of p16 gene and loss of p16 protein expression may be related to the pathogenesis and development of some cancers.
Taken together, green tea with an abundance of phytochemical Epigallocatechin-3-gallate (EGCG) may be considered as an adjunct therapy to combine with standard chemo-medicine in reduced risk and treatment of esophageal cancer.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Epigallocatechin-3-gallate promotes apoptosis and reversal of multidrug resistance in esophageal cancer cells by Liu L1, Ju Y2, Wang J3, Zhou R3.(PubMed)
(2) Epigallocatechin-3-gallate suppresses cell proliferation and promotes apoptosis in Ec9706 and Eca109 esophageal carcinoma cells by Liu L1, Zuo J1, Wang G1.(PubMed)
(3) Epigallocatechin-3-gallate inhibits growth and induces apoptosis in esophageal cancer cells through the demethylation and reactivation of the p16 gene by Meng J1, Tong Q2, Liu X2, Yu Z3, Zhang J3, Gao B3.(PubMed)
According to statistic, 2,300 Canadians will be diagnosed with esophageal cancer in 2017.
In the review of the literature published online, green tea efficacy in the treatment of human esophageal squamous cell carcinoma was expressed in a number of mechanisms.
In esophageal cancer cell lines Eca109 and Ec9706, injection of green tea EGCG plus chemo drug adriamycin (ADM) after 24 hours displayed a significantly increased cellular apoptosis.
According to flow cytometry assay, the application induced the elevation of ROS and ADM concentration in the production of toxicity to counter the reaction of tumor cell in diminished expression of mitochondrial membrane potential and ABCG2 protein to induced apoptosis, without harm to healthy cells.
ABCG2 protein expression plays a major role in multi-drug resistance, produced by tumor cells to accounter reaction to chemo-medicine.
The mitochondrial membrane potential is a central intermediate in oxidative energy metabolism, the deceased levels caused by toxicity ROS may result in energy depletion and subsequently, causing cells death.
Further observation also indicated that EGCG inhibited the growth of Eca109 and Ec9706 cells through ameliorated the anti-apoptotic bcl-2 protein expression and promoted Bax and caspase-3 protein expressions with functions in induced apoptosis in a dose- and time-dependent manner.
BCL2 family members form hetero- or homodimers and play an important anti-apoptotic protein.
Caspase-3 protein plays a central role in the execution phase of cell apoptosis.
BAX gene. BAX is a member of the Bcl-2 gene family. plays an important role in the mediation of cell death by apoptosis.
Compared to ADM treatment alone, the Eca109/ABCG2 multi-drug resistance cancer cells, the rate of apoptosis and ADM concentration were significantly higher levels of mitochondrial membrane potential and ABCG2 expression was lower.
In other words, injection of green tea plus ADM was more effective in induced cells death in Eca109/ABCG2 multi-drug resistance cancer cells with expression ROS and ADM in enhanced elevation cytotoxicity activity in compared to ADM treatment alone.
After taking into account others confounders, Dr, Liu L the lead author said, " EGCG inhibited cell growth and induced esophageal cancer cell apoptosis. It reduced the bcl-2 protein expression and increased the bax and caspase-3 protein expression. EGCG reversed multi-drug resistance by reducing ABCG2 expression and increasing the anticancer drug concentration in cancer cells".
In esophageal squamous cell carcinoma, application of Epigallocatechin-3-gallate (EGCG) without ADM measured by flow cytometry assay, after 24 hours also inhibited cancer site proliferation by increased expression of ROS to attenuate mitochondrial membrane potential function in energy metabolism and caspase-3 protein to cause malignant cellular apoptosis, in a dose and time-dependent manner.
In the examine the PCR-TRAP argentation analysis during the experiment, EGCG was also demonstrated to inhibit the viability of Eca109 and Ec9706 cells by suppressing cancer cell in alternated DNA transcript through telomerase activity.
More interestingly, the continuation of study of epigallocatechin-3-gallate (EGCG) on the human esophageal cancer cell line ECa109 also discover that EGCG demonstrated a decrease of cancer cell viability but a substantial rate of apoptosis by increased expression of p16 gene demethylation in induced cancer cell cycle arrest and apoptosis, level p16 mRNA expression in suppressed tumor progression of invasive and aggressive behavior. and p16 protein expression in promoted tumor suppressible activity, in a dose- and time-dependent manner.
P16 gene demethylation plays an important role in cell cycle arrest and apoptosis. gene alternation was found in several types of cancer.
Low level of p16 mRNA expression is associated with the progression of cancer with malignant and aggressive behavior.
Abnormalities of p16 gene and loss of p16 protein expression may be related to the pathogenesis and development of some cancers.
Taken together, green tea with an abundance of phytochemical Epigallocatechin-3-gallate (EGCG) may be considered as an adjunct therapy to combine with standard chemo-medicine in reduced risk and treatment of esophageal cancer.
For More information on yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Loose Weight
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton, Master of Nutrition
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.
Sources
(1) Epigallocatechin-3-gallate promotes apoptosis and reversal of multidrug resistance in esophageal cancer cells by Liu L1, Ju Y2, Wang J3, Zhou R3.(PubMed)
(2) Epigallocatechin-3-gallate suppresses cell proliferation and promotes apoptosis in Ec9706 and Eca109 esophageal carcinoma cells by Liu L1, Zuo J1, Wang G1.(PubMed)
(3) Epigallocatechin-3-gallate inhibits growth and induces apoptosis in esophageal cancer cells through the demethylation and reactivation of the p16 gene by Meng J1, Tong Q2, Liu X2, Yu Z3, Zhang J3, Gao B3.(PubMed)
Bromelain, Suppresses the Risk and Onset of Colitis
Colitis is a medical condition characterized by the inflammation of the large intestine, including the colon, caecum, and rectum.
Depending on the types of colitis, most common prevalent factors found in patients with such as condition are.
* Familial history of inflammatory bowel disease (odds ratio (OR) 4.3)
* Breastfeeding (OR 2.1)
* Bacille Calmette-Guerin vaccination (OR 3.6 )
* History of eczema (OR 2.1 (1-4.5))
* Disease during pregnancy (OR 8.9 (1.5-52)), and
* Bedroom sharing (OR 7.1 (1.9-27.4))
* Crohn's disease both appendectomy and tonsillectomy have positive associations. Well-established
* Smoking status
* If you are over 50, you are at increased to develop colitis.
And * Depression and psychosocial stress, according to the basis of data from the Nurses' Health Study, increase the risk for CD, but not UC, among women. Psychological factors might have been found to induce CD developing.
Furthermore, patients with medicals condition such as hypertension, diabetes, hyperlipidemia, and atrial fibrillation are associated with increased risk to develop ischemic colitis(IC), according to the study by Beijing Hospital, Ministry of Health.
Believe it or not, regular drinking of tap water was a protective factor and ulcerative colitis appendicectomy was a protective factor.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a potential compound for the treatment of colitis, researchers examined the effects of bromelain on the inflammatory response that lead to the onset of colitis.
In epithelial TNFR in rats colitis induced by the intracolonic administration of 2, 4, 6-trinitrobenzene sulfonic acid, injection of purified fruit bromelain (PFB) significantly decreased the increased expression of TNFR1 and TNFR2.
Where TNF-α receptor (TNFR) is a proinflammatory cytokine activated by the immune response.
Furthermore, typical symptoms associated with colitis such as infiltration of inflammatory cells, cytokine profiles, epithelial cell apoptosis, and epithelial tight junction barrier dysfunction were significantly ameliorated by PFB.
According to the chemical analysis, fruit bromelain showed a superior inhibition of TNFR2 than that exhibited on TNFR1 compared to those of stem bromelain complex.
In other words, PFB expressed its anti-inflammatory activity by blocking the activation of high expression of epithelial TNFRs.
Based on the findings, researchers said, "PFB-induced TNFR inhibition ameliorated colitis symptoms. These results supply novel insights into potential IBD treatment by PFB".
In other to reveal more information of bromelain anti colitis effects, researchers evaluated the long-term dietary supplementation with pineapple (supplied as juice) in decreasing colon inflammation and neoplasia in Il10(-/-) mice with chronic colitis as compared with bromelain derived from the stem.
Colitis triggered in Il10(-/-) mice by exposure to the non-steroidal anti-inflammatory drug piroxicam for 6 month showed a decreased histologic colon inflammation scores and lower incidence of inflammation-associated colonic neoplasia (35% versus 66%; P < 0.02), with fewer neoplastic lesions/colon (P = 0.05) after receiving treatment of fresh juice.
According to the tested assays, fresh pineapple juice demonstrated proteolytic activity in removing cell surface molecules that can affect leukocyte response.
Dr. Hale LP, the lead scientist wrote in the final report, "long-term dietary supplementation with fresh or unpasteurized frozen pineapple juice with proteolytically active bromelain enzymes is safe and decreases inflammation severity and the incidence and multiplicity of inflammation-associated colonic neoplasia in this commonly used murine model of inflammatory bowel disease".
Taken altogether, bromelain used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of colitis-associated with inflammatory bowel disease, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in IL-10-deficient mice with colitis by Hale LP1, Chichlowski M, Trinh CT, Greer PK. (PubMed)
(2) Inhibition of Epithelial TNF-α Receptors by Purified Fruit Bromelain Ameliorates Intestinal Inflammation and Barrier Dysfunction in Colitis by Zhou Z1, Wang L1, Feng P1, Yin L2, Wang C3, Zhi S3, Dong J1, Wang J1, Lin Y2, Chen D1, Xiong Y4,5, Peng J. (PubMed)
(3) Colitis - The Risk Factors by Kyle J. Norton
Depending on the types of colitis, most common prevalent factors found in patients with such as condition are.
* Familial history of inflammatory bowel disease (odds ratio (OR) 4.3)
* Breastfeeding (OR 2.1)
* Bacille Calmette-Guerin vaccination (OR 3.6 )
* History of eczema (OR 2.1 (1-4.5))
* Disease during pregnancy (OR 8.9 (1.5-52)), and
* Bedroom sharing (OR 7.1 (1.9-27.4))
* Crohn's disease both appendectomy and tonsillectomy have positive associations. Well-established
* Smoking status
* If you are over 50, you are at increased to develop colitis.
And * Depression and psychosocial stress, according to the basis of data from the Nurses' Health Study, increase the risk for CD, but not UC, among women. Psychological factors might have been found to induce CD developing.
Furthermore, patients with medicals condition such as hypertension, diabetes, hyperlipidemia, and atrial fibrillation are associated with increased risk to develop ischemic colitis(IC), according to the study by Beijing Hospital, Ministry of Health.
Believe it or not, regular drinking of tap water was a protective factor and ulcerative colitis appendicectomy was a protective factor.
Bromelain, a proteolytic enzyme found in pineapples (Ananas comosus) has been used in traditional medicine as an inflammatory agent and to treat pains, strains, and muscle aches and pains and ease back pain and chronic joint pain, skin diseases, etc.
With an aim to find a potential compound for the treatment of colitis, researchers examined the effects of bromelain on the inflammatory response that lead to the onset of colitis.
In epithelial TNFR in rats colitis induced by the intracolonic administration of 2, 4, 6-trinitrobenzene sulfonic acid, injection of purified fruit bromelain (PFB) significantly decreased the increased expression of TNFR1 and TNFR2.
Where TNF-α receptor (TNFR) is a proinflammatory cytokine activated by the immune response.
Furthermore, typical symptoms associated with colitis such as infiltration of inflammatory cells, cytokine profiles, epithelial cell apoptosis, and epithelial tight junction barrier dysfunction were significantly ameliorated by PFB.
According to the chemical analysis, fruit bromelain showed a superior inhibition of TNFR2 than that exhibited on TNFR1 compared to those of stem bromelain complex.
In other words, PFB expressed its anti-inflammatory activity by blocking the activation of high expression of epithelial TNFRs.
Based on the findings, researchers said, "PFB-induced TNFR inhibition ameliorated colitis symptoms. These results supply novel insights into potential IBD treatment by PFB".
In other to reveal more information of bromelain anti colitis effects, researchers evaluated the long-term dietary supplementation with pineapple (supplied as juice) in decreasing colon inflammation and neoplasia in Il10(-/-) mice with chronic colitis as compared with bromelain derived from the stem.
Colitis triggered in Il10(-/-) mice by exposure to the non-steroidal anti-inflammatory drug piroxicam for 6 month showed a decreased histologic colon inflammation scores and lower incidence of inflammation-associated colonic neoplasia (35% versus 66%; P < 0.02), with fewer neoplastic lesions/colon (P = 0.05) after receiving treatment of fresh juice.
According to the tested assays, fresh pineapple juice demonstrated proteolytic activity in removing cell surface molecules that can affect leukocyte response.
Dr. Hale LP, the lead scientist wrote in the final report, "long-term dietary supplementation with fresh or unpasteurized frozen pineapple juice with proteolytically active bromelain enzymes is safe and decreases inflammation severity and the incidence and multiplicity of inflammation-associated colonic neoplasia in this commonly used murine model of inflammatory bowel disease".
Taken altogether, bromelain used alone or combined with conventional medicine may be considered a remedy for the prevention and treatment of colitis-associated with inflammatory bowel disease, pending to the confirmation of the larger sample size and multicenter human study.
Intake of bromelain in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in IL-10-deficient mice with colitis by Hale LP1, Chichlowski M, Trinh CT, Greer PK. (PubMed)
(2) Inhibition of Epithelial TNF-α Receptors by Purified Fruit Bromelain Ameliorates Intestinal Inflammation and Barrier Dysfunction in Colitis by Zhou Z1, Wang L1, Feng P1, Yin L2, Wang C3, Zhi S3, Dong J1, Wang J1, Lin Y2, Chen D1, Xiong Y4,5, Peng J. (PubMed)
(3) Colitis - The Risk Factors by Kyle J. Norton
Healthy Food Turmeric Protects the Kidney Against Renal Dysfunction
Renal protection is strategies that protect the kidney against injury or damage. In other words, renal protection is a process that maintains the function of the kidneys.
Kidneys, a pair of the bean-shaped organ in the human body only filters out blood but also balances the body fluids by eliminating them and remove them through urinary secretion.
Depending on the severity of renal damage, patients may experience symptoms of decreased urine output, fluid retention, that lead to swelling in the legs, ankles or feet, fatigue, nausea, and physical weakness
In severe cases, patients may also have symptoms of shortness of breath, confusion, and irregular heartbeat.
The worse cases of kidney damage can lead to renal failure, a condition that induces wastes and toxins accumulated in the blood. In this stage, dialysis and kidney transplant are the only options.
Kidney damage can be classified into 4 different stages
* Stage 1 with normal or high GFR (GFR > 90 mL/min). In this stage of kidney patients are assymptomatic.
* Stage 2 Mild CKD (GFR = 60-89 mL/min), Patients in this stage also experience no symptoms.
*Stage 3A Moderate CKD (GFR = 45-59 mL/min) and 3B moderate CKD (GFR = 30-44 mL/min.
Most patients are assymptomatic. However, some patients may experience symptoms of mild swelling in the hands and feet, back pain and urinating more or less than normal.
* Stage 4 CKD (GFR = 15-30 mL/min). Most patients in this stage experience more severe symptoms of swelling in the hands and feet, back pain and urinating more or less than normal, accompanied by other health problem associated with weakened kidney function
* Stage 5 EndStage CKD (GFR <15 mL/min). Patients at this advanced stage are very close to renal failure or renal failure. Symptoms are getting worse.
Where eGFR is short for estimated glomerular filtration rate.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to find a potential compound with the kidney protective effect against the side effects of Cisplatin, researchers investigated the protective effect and mechanism of tetrahydrocurcumin on cisplatin-induced kidney damage.
The study included selected rats treated by Tetrahydrocurcumin orally every day at a dose of 80 mg/kg body weight for ten days, and a single dose of cisplatin was administered intraperitoneally (7.5 mg/kg body weight) in 0.9 % saline on day four.
According to the tested assays, Cisplatin-induced renal cell damage was significantly reduced by tetrahydrocurcumin treatment.
Tetrahydrocurcumin also suppressed the cisplatin-treated rat in inducing overexpression of the creatinine clearance levels, an indication of kidney dysfunction.
Proinflammatory protein associated with increased oxidative stress in the kidney caused by cancer medicine was also inhibited by tetrahydrocurcumin administration during the experiment.
After taking into account co and confounders, the researcher wrote, "collectively provide therapeutic evidence that tetrahydrocurcumin ameliorates renal damage by regulating inflammation and apoptosis".
In order to reveal more information about turmeric renal protective activity, researchers evaluated the intervening effects of Curcuma aromatica oil on renal interstitial fibrosis rats induced by unilateral ureteral obstruction.
The study included infected rats treated with Curcuma aromatica oil on 3, 7, 14, and 28 days.
According to the Nuclear magnetic resonance (NMR)-based metabonomics combined with clinical chemistry and histopathology examination, Curcuma aromatica oil demonstrated strong kidney protection by inhibiting some metabolic pathways associated with the onset of renal interstitial fibrosis, including lipids metabolism, glycolysis, and methylamine metabolism,
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the protection of kidneys, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effect of tetrahydrocurcumin against cisplatin-induced renal damage: in vitro and in vivo studies by Song KI1, Park JY2, Lee S3, Lee D2, Jang HJ4, Kim SN3, Ko H5, Kim HY6, Lee JW3, Hwang GS2, Kang KS2, Yamabe N. (PubMed)
(2) Serum metabonomic analysis of protective effects of Curcuma aromatica oil on renal fibrosis rats by Zhao L1, Zhang H1, Yang Y2, Zheng Y1, Dong M1, Wang Y1, Bai G3, Ye X3, Yan Z3, Gao H. (PubMed)
Kidneys, a pair of the bean-shaped organ in the human body only filters out blood but also balances the body fluids by eliminating them and remove them through urinary secretion.
Depending on the severity of renal damage, patients may experience symptoms of decreased urine output, fluid retention, that lead to swelling in the legs, ankles or feet, fatigue, nausea, and physical weakness
In severe cases, patients may also have symptoms of shortness of breath, confusion, and irregular heartbeat.
The worse cases of kidney damage can lead to renal failure, a condition that induces wastes and toxins accumulated in the blood. In this stage, dialysis and kidney transplant are the only options.
Kidney damage can be classified into 4 different stages
* Stage 1 with normal or high GFR (GFR > 90 mL/min). In this stage of kidney patients are assymptomatic.
* Stage 2 Mild CKD (GFR = 60-89 mL/min), Patients in this stage also experience no symptoms.
*Stage 3A Moderate CKD (GFR = 45-59 mL/min) and 3B moderate CKD (GFR = 30-44 mL/min.
Most patients are assymptomatic. However, some patients may experience symptoms of mild swelling in the hands and feet, back pain and urinating more or less than normal.
* Stage 4 CKD (GFR = 15-30 mL/min). Most patients in this stage experience more severe symptoms of swelling in the hands and feet, back pain and urinating more or less than normal, accompanied by other health problem associated with weakened kidney function
* Stage 5 EndStage CKD (GFR <15 mL/min). Patients at this advanced stage are very close to renal failure or renal failure. Symptoms are getting worse.
Where eGFR is short for estimated glomerular filtration rate.
Turmeric is a perennial plant in the genus Curcuma, belonging to the family Zingiberaceae, native to tropical South Asia.
The herb has been used in traditional medicine as anti-oxidant, hypoglycemic, colorant, antiseptic, wound healing agent, and to treat flatulence, bloating, and appetite loss, ulcers, eczema, inflammations, etc.
In the urgency to find a potential compound with the kidney protective effect against the side effects of Cisplatin, researchers investigated the protective effect and mechanism of tetrahydrocurcumin on cisplatin-induced kidney damage.
The study included selected rats treated by Tetrahydrocurcumin orally every day at a dose of 80 mg/kg body weight for ten days, and a single dose of cisplatin was administered intraperitoneally (7.5 mg/kg body weight) in 0.9 % saline on day four.
According to the tested assays, Cisplatin-induced renal cell damage was significantly reduced by tetrahydrocurcumin treatment.
Tetrahydrocurcumin also suppressed the cisplatin-treated rat in inducing overexpression of the creatinine clearance levels, an indication of kidney dysfunction.
Proinflammatory protein associated with increased oxidative stress in the kidney caused by cancer medicine was also inhibited by tetrahydrocurcumin administration during the experiment.
After taking into account co and confounders, the researcher wrote, "collectively provide therapeutic evidence that tetrahydrocurcumin ameliorates renal damage by regulating inflammation and apoptosis".
In order to reveal more information about turmeric renal protective activity, researchers evaluated the intervening effects of Curcuma aromatica oil on renal interstitial fibrosis rats induced by unilateral ureteral obstruction.
The study included infected rats treated with Curcuma aromatica oil on 3, 7, 14, and 28 days.
According to the Nuclear magnetic resonance (NMR)-based metabonomics combined with clinical chemistry and histopathology examination, Curcuma aromatica oil demonstrated strong kidney protection by inhibiting some metabolic pathways associated with the onset of renal interstitial fibrosis, including lipids metabolism, glycolysis, and methylamine metabolism,
Taken altogether, turmeric processed abundantly bioactive compound curcumin may be considered supplements for the protection of kidneys, pending to the confirmation of the larger sample size and multicenter human study.
Intake of turmeric in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Protective effect of tetrahydrocurcumin against cisplatin-induced renal damage: in vitro and in vivo studies by Song KI1, Park JY2, Lee S3, Lee D2, Jang HJ4, Kim SN3, Ko H5, Kim HY6, Lee JW3, Hwang GS2, Kang KS2, Yamabe N. (PubMed)
(2) Serum metabonomic analysis of protective effects of Curcuma aromatica oil on renal fibrosis rats by Zhao L1, Zhang H1, Yang Y2, Zheng Y1, Dong M1, Wang Y1, Bai G3, Ye X3, Yan Z3, Gao H. (PubMed)
Friday, July 26, 2019
Green tea, in Reduced Risk and Treatment of Alzheimer's disease
Alzheimer's disease is a neurodegenerative condition of loss or decrease of cognitive and memory functions due to aging.
According to the Maternal and Infant Health, ASL NA 3 SUD, epigallocatechin, and gallic acid, (-)-Epigallocatechin-3-Gallate (EGCG), found in green tea exerted a strong anti-inflammatory and anti oxidative properties in protection against neuronal damage and brain edema.
The study also stated that green tea may also contribute to reduced risk and treatment of AD by ameliorated chronic viral infection, one of the cause in responsible for AD's neuropathology.
Dr. Mandel SA. the lead author and expert in green tea study said, "tea drinking may decrease the incidence of dementia, AD, and PD. In particular, its main catechin polyphenol constituent (-)-epigallocatechin-3-gallate (EGCG) has been shown to exert neuroprotective/neurorescue activities in a wide array of cellular and animal models of neurological disorders".
Other researchers suggested that the efficacy of epigallocatechin and gallic acid, (-)-Epigallocatechin-3-Gallate (EGCG) in reduced risk of AD may be attributed to
1. The antioxidant activity in ameliorating production of ROS in the induced risk of oxidative stress which has been found to associate to the production of lipid peroxidation, leading to abnormal deposition of amyloid β (Aβ) peptide
2. Free radical overexpression in aging people also vulnerable to an imbalance of antioxidant and ROS
may have negatively direct interaction with proteins, nucleic acids, and other molecules and may also alter their structures and functions in inducing risk AD.
Indeed, as a single ingredient isolated from green tea, epigallocatechin and gallic acid, (-)-Epigallocatechin-3-Gallate (EGCG) have been found to cause toxicity in some cases in the medical literature. Therefore taking the ingredient in long term and overdoses may have an implication of liver damage.
In an animal study to evaluate the efficacy of Caffeic acid in AD, mice rats randomly divided into three groups: i) control group, ii) AD model group and iii) caffeic acid group, mice fed with the phytochemical expressed a significant in increased learning deficit and cognitive function demonstrated by the Morris water maze task in compared control.
Additionally, fed mice also displayed attenuated oxidative stress, inflammation, nuclear factor‑κB‑p65 protein expression involved inflammatory cytokines production and suppressed caspase‑3 activity-induced cell death and other mechanisms in the rats with AD.
Interestingly, the inflammatory process has shown to have a negative role in an increased risk of AD, by causing neuroinflammation, including brain cells such as microglia and astrocytes and subsequently in promoted dysfunction and neuronal death. Therefore by suppressing the production of inflammatory cytokines, caffeic acid expressed a significant reduction of AD risk.
The efficacy in the contribution of cognitive improvement following caffeic acid application may be due to its antioxidant activity and restoration of cholinergic functions, as deficiency of cholinergic function has shown to affect cognition, behavior, and activities of daily living
Taking all together, there is no doubt that green process a neuroprotective against the risk and progression of patients with Alzheimer's disease (AD) attributed to some of the major chemical constituents. But the intake of a single ingredient isolated from green tea should be taken with care.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The efficacy of Epigallocatechin-3-gallate (green tea) in the treatment of Alzheimer's disease: an overview of pre-clinical studies and translational perspectives in clinical practice by Cascella M#1, Bimonte S#1, Muzio MR2, Schiavone V3, Cuomo A1.(PubMed)
(2) Simultaneous manipulation of multiple brain targets by green tea catechins: a potential neuroprotective strategy for Alzheimer and Parkinson diseases by Mandel SA1, Amit T, Weinreb O, Reznichenko L, Youdim MB.(PubMed)
(3) Effects of caffeic acid on learning deficits in a model of Alzheimer's disease by Wang Y1, Wang Y2, Li J1, Hua L3, Han B1, Zhang Y1, Yang X3, Zeng Z3, Bai H3, Yin H1, Lou J3.(PubMed)
(4) Caffeic acid attenuates oxidative stress, learning and memory deficit in intra-cerebroventricular streptozotocin induced experimental dementia in rats by Deshmukh R1, Kaundal M2, Bansal V2, Samardeep2(PubMed).
According to the Maternal and Infant Health, ASL NA 3 SUD, epigallocatechin, and gallic acid, (-)-Epigallocatechin-3-Gallate (EGCG), found in green tea exerted a strong anti-inflammatory and anti oxidative properties in protection against neuronal damage and brain edema.
The study also stated that green tea may also contribute to reduced risk and treatment of AD by ameliorated chronic viral infection, one of the cause in responsible for AD's neuropathology.
Dr. Mandel SA. the lead author and expert in green tea study said, "tea drinking may decrease the incidence of dementia, AD, and PD. In particular, its main catechin polyphenol constituent (-)-epigallocatechin-3-gallate (EGCG) has been shown to exert neuroprotective/neurorescue activities in a wide array of cellular and animal models of neurological disorders".
Other researchers suggested that the efficacy of epigallocatechin and gallic acid, (-)-Epigallocatechin-3-Gallate (EGCG) in reduced risk of AD may be attributed to
1. The antioxidant activity in ameliorating production of ROS in the induced risk of oxidative stress which has been found to associate to the production of lipid peroxidation, leading to abnormal deposition of amyloid β (Aβ) peptide
2. Free radical overexpression in aging people also vulnerable to an imbalance of antioxidant and ROS
may have negatively direct interaction with proteins, nucleic acids, and other molecules and may also alter their structures and functions in inducing risk AD.
Indeed, as a single ingredient isolated from green tea, epigallocatechin and gallic acid, (-)-Epigallocatechin-3-Gallate (EGCG) have been found to cause toxicity in some cases in the medical literature. Therefore taking the ingredient in long term and overdoses may have an implication of liver damage.
In an animal study to evaluate the efficacy of Caffeic acid in AD, mice rats randomly divided into three groups: i) control group, ii) AD model group and iii) caffeic acid group, mice fed with the phytochemical expressed a significant in increased learning deficit and cognitive function demonstrated by the Morris water maze task in compared control.
Additionally, fed mice also displayed attenuated oxidative stress, inflammation, nuclear factor‑κB‑p65 protein expression involved inflammatory cytokines production and suppressed caspase‑3 activity-induced cell death and other mechanisms in the rats with AD.
Interestingly, the inflammatory process has shown to have a negative role in an increased risk of AD, by causing neuroinflammation, including brain cells such as microglia and astrocytes and subsequently in promoted dysfunction and neuronal death. Therefore by suppressing the production of inflammatory cytokines, caffeic acid expressed a significant reduction of AD risk.
The efficacy in the contribution of cognitive improvement following caffeic acid application may be due to its antioxidant activity and restoration of cholinergic functions, as deficiency of cholinergic function has shown to affect cognition, behavior, and activities of daily living
Taking all together, there is no doubt that green process a neuroprotective against the risk and progression of patients with Alzheimer's disease (AD) attributed to some of the major chemical constituents. But the intake of a single ingredient isolated from green tea should be taken with care.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The efficacy of Epigallocatechin-3-gallate (green tea) in the treatment of Alzheimer's disease: an overview of pre-clinical studies and translational perspectives in clinical practice by Cascella M#1, Bimonte S#1, Muzio MR2, Schiavone V3, Cuomo A1.(PubMed)
(2) Simultaneous manipulation of multiple brain targets by green tea catechins: a potential neuroprotective strategy for Alzheimer and Parkinson diseases by Mandel SA1, Amit T, Weinreb O, Reznichenko L, Youdim MB.(PubMed)
(3) Effects of caffeic acid on learning deficits in a model of Alzheimer's disease by Wang Y1, Wang Y2, Li J1, Hua L3, Han B1, Zhang Y1, Yang X3, Zeng Z3, Bai H3, Yin H1, Lou J3.(PubMed)
(4) Caffeic acid attenuates oxidative stress, learning and memory deficit in intra-cerebroventricular streptozotocin induced experimental dementia in rats by Deshmukh R1, Kaundal M2, Bansal V2, Samardeep2(PubMed).
Phytochemical Lycopene Inhibits Hyperproliferation In Gastric Epithelial Cells
Hyperproliferation is a progression of highly invasive tumor associated with an abnormally high rate of cancer cells division, leading to rapid overgrowth of the tumor.
Gastric cancer or stomach cancer is a medical condition caused by irregular cell growth of the inner lining tissues of the stomach.
Most cancer of gastric start in the cells on the inner lining of the stomach before penetrating into deeper layers.
At the advanced stage, cancerous gastric cells can also travel a distance away to an alternate DNA of healthy cells, leading a secondary metastasis.
According to the statistics provided by the Canadian Cancer Society, In 2017, approximately 3,500 Canadians were diagnosed with stomach cancer, and gastric cancer also caused the death of 2,100 including 1,300 women and 790 men.
There are major types of gastric cancer
*Adenocarcinoma, accounting to over 90% of gastric cancer diagnosed each year is a type of cancer developed in the innermost lining of the stomach (the mucosa).
* Lymphoma is a type of cancer associated with the immune system found in the wall of the stomach.
Most common symptoms of gastric cancer are heartburn or indigestion, abdominal pain or vague discomfort in the abdomen, usually above the navel and a sense of fullness in the upper abdomen after eating a small meal accompanied by the general symptoms shared by other types of cancer.
In severe cases, if the oversize tumor has pressed on the nearby blood vessel, patients may experience the symptom of vomiting blood.
Out of many prevalent factors involved in the cancer onset, some researchers suggested the promotion of the Western diet may have a strong and negative implication on the cancer occurrence in North America.
Dr. Bertuccio P, the lead scientist wrote, "An unfavorable role on GC emerged for the 'Western/unhealthy' dietary pattern, with an OR of 1.51 (95% CI: 1.21-1.89). This association was weaker for the distal/NOS (not otherwise specified) category (OR = 1.36) compared with the cardia GC (OR = 2.05). Among the a priori scores, the ORs ranged from 0.2 to 0.7 for the favorable and from 1.8 to 6.9 for the unfavorable ones".
And, "There is a ~2-fold difference in GC risk between a 'Prudent/healthy' diet-rich in fruits and vegetables, and a 'Western/unhealthy' diet-rich in starchy foods, meat, and fats".
Lycopene is a phytochemical in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
With an aim to find a potential compound for the treatment of invasive gastric cancer, researchers examined the lycopene effect on Helicobacter pylori (H pylori) colonized human stomach in the risk of gastric cancer.
According to the tested differentiation, injection lycopene reduced ROS levels by inhibiting Jak1/Stat3 activation associated with increased levels of proinflammatory cytokines, alteration of Wnt/β-catenin multiprotein signal in induced cells proliferation, and differentiation.
Furthermore, the levels of ROS also are decreased observed by the inhibition of c-Myc, a protein which plays a critical role in cellular growth regulation and cellular metabolism and cyclin E in cell duplication and cell proliferation in H pylori-infected AGS cells, derived from an adenocarcinoma of the stomach.
In other words, lycopene protects the gastric cell by constraining the expression of ROS through several aforementioned mechanisms.
Based on the findings, researchers said, " Lycopene might be a potential and promising nutrient for preventing H pylori-associated gastric diseases including gastric cancer".
Furthermore, according to the results of HGC-27 cells which were treated with varying concentration lycopene for 24, 48, 72,
* Lycopene displayed antiproliferative activity in HGC-27 cell lines.
* Lycopene inhibited HGC-27 by enhancing the protein LC3 which is essential for cancer cell autophagy and p-ERK proteins expression that impaired regeneration of intracellular antioxidants.
Furthermore, in gastric cancer nude mice model, lycopene treatment also significantly decreased tumor weight or tumor proliferation.
Taken altogether, lycopene may be considered supplements for the prevention and treatment of gastric cancer, pending on the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lycopene treatment inhibits activation of Jak1/Stat3 and Wnt/β-catenin signaling and attenuates hyperproliferation in gastric epithelial cells byPark B1, Lim JW2, Kim H. (PubMed)
(2) INHIBITORY EFFECT OF LYCOPENE AGAINST THE GROWTH OF HUMAN GASTRIC CANCER CELLS by Zhou S1, Zhang R1, Bi T1, Lu Y1, Jiang L. (PubMed)
(3) Dietary patterns and gastric cancer risk: a systematic review and meta-analysis by Bertuccio P1, Rosato V, Andreano A, Ferraroni M, Decarli A, Edefonti V, La Vecchia C. (PubMed)
Gastric cancer or stomach cancer is a medical condition caused by irregular cell growth of the inner lining tissues of the stomach.
Most cancer of gastric start in the cells on the inner lining of the stomach before penetrating into deeper layers.
At the advanced stage, cancerous gastric cells can also travel a distance away to an alternate DNA of healthy cells, leading a secondary metastasis.
According to the statistics provided by the Canadian Cancer Society, In 2017, approximately 3,500 Canadians were diagnosed with stomach cancer, and gastric cancer also caused the death of 2,100 including 1,300 women and 790 men.
There are major types of gastric cancer
*Adenocarcinoma, accounting to over 90% of gastric cancer diagnosed each year is a type of cancer developed in the innermost lining of the stomach (the mucosa).
* Lymphoma is a type of cancer associated with the immune system found in the wall of the stomach.
Most common symptoms of gastric cancer are heartburn or indigestion, abdominal pain or vague discomfort in the abdomen, usually above the navel and a sense of fullness in the upper abdomen after eating a small meal accompanied by the general symptoms shared by other types of cancer.
In severe cases, if the oversize tumor has pressed on the nearby blood vessel, patients may experience the symptom of vomiting blood.
Out of many prevalent factors involved in the cancer onset, some researchers suggested the promotion of the Western diet may have a strong and negative implication on the cancer occurrence in North America.
Dr. Bertuccio P, the lead scientist wrote, "An unfavorable role on GC emerged for the 'Western/unhealthy' dietary pattern, with an OR of 1.51 (95% CI: 1.21-1.89). This association was weaker for the distal/NOS (not otherwise specified) category (OR = 1.36) compared with the cardia GC (OR = 2.05). Among the a priori scores, the ORs ranged from 0.2 to 0.7 for the favorable and from 1.8 to 6.9 for the unfavorable ones".
And, "There is a ~2-fold difference in GC risk between a 'Prudent/healthy' diet-rich in fruits and vegetables, and a 'Western/unhealthy' diet-rich in starchy foods, meat, and fats".
Lycopene is a phytochemical in the class of carotenoid, a natural pigment with no vitamin A activity found abundantly in tomatoes and other red fruits and vegetables, such as red carrots, watermelons, and papayas,
Tomatoes provide about 80% of the lycopene in the world diet. In plants, lycopene protects the host against excessive photodamage and performs various functions in photosynthesis.
With an aim to find a potential compound for the treatment of invasive gastric cancer, researchers examined the lycopene effect on Helicobacter pylori (H pylori) colonized human stomach in the risk of gastric cancer.
According to the tested differentiation, injection lycopene reduced ROS levels by inhibiting Jak1/Stat3 activation associated with increased levels of proinflammatory cytokines, alteration of Wnt/β-catenin multiprotein signal in induced cells proliferation, and differentiation.
Furthermore, the levels of ROS also are decreased observed by the inhibition of c-Myc, a protein which plays a critical role in cellular growth regulation and cellular metabolism and cyclin E in cell duplication and cell proliferation in H pylori-infected AGS cells, derived from an adenocarcinoma of the stomach.
In other words, lycopene protects the gastric cell by constraining the expression of ROS through several aforementioned mechanisms.
Based on the findings, researchers said, " Lycopene might be a potential and promising nutrient for preventing H pylori-associated gastric diseases including gastric cancer".
Furthermore, according to the results of HGC-27 cells which were treated with varying concentration lycopene for 24, 48, 72,
* Lycopene displayed antiproliferative activity in HGC-27 cell lines.
* Lycopene inhibited HGC-27 by enhancing the protein LC3 which is essential for cancer cell autophagy and p-ERK proteins expression that impaired regeneration of intracellular antioxidants.
Furthermore, in gastric cancer nude mice model, lycopene treatment also significantly decreased tumor weight or tumor proliferation.
Taken altogether, lycopene may be considered supplements for the prevention and treatment of gastric cancer, pending on the confirmation of the larger sample size and multicenter human study.
Intake of lycopene in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How-To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Lycopene treatment inhibits activation of Jak1/Stat3 and Wnt/β-catenin signaling and attenuates hyperproliferation in gastric epithelial cells byPark B1, Lim JW2, Kim H. (PubMed)
(2) INHIBITORY EFFECT OF LYCOPENE AGAINST THE GROWTH OF HUMAN GASTRIC CANCER CELLS by Zhou S1, Zhang R1, Bi T1, Lu Y1, Jiang L. (PubMed)
(3) Dietary patterns and gastric cancer risk: a systematic review and meta-analysis by Bertuccio P1, Rosato V, Andreano A, Ferraroni M, Decarli A, Edefonti V, La Vecchia C. (PubMed)
Thursday, July 25, 2019
Green Tea, A Potent Beverage in Reduced Risk and Treatment of Osteosarcoma
Osteosarcoma is a medical condition of bone cancer characterized by producing immature bone and occurred mostly in children and young adults between the ages of 10 and 30.
According to the study in the investigation of the effects of Epigallocatechin-3-gallate (EGCG), in reduced risk of osteosarcoma expression in compared to miR-126 in the proliferation, invasion, migration, and chemotherapeutics resistance in cancer, application of Epigallocatechin-3-gallate (EGCG)
1. Exerted a significant effect in suppresses proliferation of human cell line osteosarcoma MG63 and U2OS cells in a concentration-dependent and time-dependent manner
2. Inhibited cancer cell line at the concentration of 0.05 g/L on U2OS cells were equivalent to 20 μM cisplatin (DDP)
In compared to green tea extract induced cell death by interfering in cell cycle arrest, miR-126, the chemo suppressor drug-induced apoptosis and inhibited proliferation in U2OS cell line but without significant effects on phase 1 of cancerous cell cycle division.
Further analysis, researchers suggested the application of Epigallocatechin-3-gallate (EGCG) may increase the effect of tumor-suppressing drug miR-126 and for treatment of osteosarcoma.
In fact, the inhibition of miR-126 osteosarcoma cells without inducing apoptosis and cells proliferation in cell cycle division is attributed to the medicine in the target of sequences in reducing the expression of the targeted genes.
In other words, the medicine can bind directly to inhibit DNA transcription and prevented mRNA in transmitting such transcription in initiated cancer development.
Other researchers suggested that the inhibition of Epigallocatechin-3-gallate (EGCG) in reduced cancerous cell death does not limit to the function of cell cycle arrest, the phytochemical compound also expressed the apoptotic effect through modulating gene expression of cancer cell line and induced degradation of cancerous cellular structure.
Additional evaluation of the phytochemical Epigallocatechin-3-gallate (EGCG) and the tumor suppressed drug miR-1 effect in osteosarcoma, researchers also found that Epigallocatechin-3-gallate has a profound and positive effect in improved the efficacy of miR-1 in induced cell apoptosis and proliferation observed in cancer cell lines MG-63 and U-2OS.
More importantly, MG-63 and U-2OS treated by miR-1 and Epigallocatechin-3-gallate (EGCG) decreased c-MET expression, which is an indication of cancers development.
Furthermore, the combined application of Epigallocatechin-3-gallate (EGCG) and c-MET inhibitor (crizotinib) also displayed significant inhibition of MG-63 and U-2OS cancer cell proliferation.
More interestingly, in the study of the effects of Se-enriched Ziyang green tea, containing chemical compound mannose, rhamnose and fucose in antitumor activity on human osteosarcoma U-2 OS cells in vitro and in vivo, researchers found that Se-ZYTP at concentration of 25, 50, 100 and 200 μg/ml exerted a significant inhibition of proliferation of human osteosarcoma U-2 OS cells in a concentration-dependent fashion.
In cancer cell line In U-2 OS cancer induced in BALB/c athymic mice model, Se-ZYTP oral administration at three doses of 100, 200 and 400mg/kg body weight (B.W.) daily for 28 days resulted in tumor regression as compared to model control without causing any serious side effects.
Once again, we illustrated that other chemical compounds found in green tea may also have the potential in the suppression of proliferation and induced apoptosis of osteosarcoma.
Indeed, the anti osteosarcoma activities of Se-enriched Ziyang green tea may be attributed to the stimulation in increased pro-apoptotic protein Bax expression(upregulated by the tumor suppressor protein p53 in induced apoptosis) and decreased expression levels of anti-apoptotic protein Bcl-2(regulator proteins that regulate cell death) and NG2(involved cell survival, migration, and angiogenesis), some researchers suggested.
Taking all together, green tea with plenty of phytochemicals in the suppression of the development and progression of cancer may be considered as an adjunct therapy in reduced risk and combination with chemo drugs for the treatment of osteosarcoma.
For More information about yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Overexpression of miR-126 sensitizes osteosarcoma cells to apoptosis induced by epigallocatechin-3-gallate by Jiang L, Tao C, He A, He X1.(PubMed)
92) Green tea polyphenol EGCG suppresses osteosarcoma cell growth through upregulating miR-1 by Zhu K1, Wang W2.(PubMed)
(3) Tumoricidal effects of a selenium (Se)-polysaccharide from Ziyang green tea on human osteosarcoma U-2 OS cells by Wang Y1, Chen J, Zhang D, Zhang Y, Wen Y, Li L, Zheng L.(PubMed)
According to the study in the investigation of the effects of Epigallocatechin-3-gallate (EGCG), in reduced risk of osteosarcoma expression in compared to miR-126 in the proliferation, invasion, migration, and chemotherapeutics resistance in cancer, application of Epigallocatechin-3-gallate (EGCG)
1. Exerted a significant effect in suppresses proliferation of human cell line osteosarcoma MG63 and U2OS cells in a concentration-dependent and time-dependent manner
2. Inhibited cancer cell line at the concentration of 0.05 g/L on U2OS cells were equivalent to 20 μM cisplatin (DDP)
In compared to green tea extract induced cell death by interfering in cell cycle arrest, miR-126, the chemo suppressor drug-induced apoptosis and inhibited proliferation in U2OS cell line but without significant effects on phase 1 of cancerous cell cycle division.
Further analysis, researchers suggested the application of Epigallocatechin-3-gallate (EGCG) may increase the effect of tumor-suppressing drug miR-126 and for treatment of osteosarcoma.
In fact, the inhibition of miR-126 osteosarcoma cells without inducing apoptosis and cells proliferation in cell cycle division is attributed to the medicine in the target of sequences in reducing the expression of the targeted genes.
In other words, the medicine can bind directly to inhibit DNA transcription and prevented mRNA in transmitting such transcription in initiated cancer development.
Other researchers suggested that the inhibition of Epigallocatechin-3-gallate (EGCG) in reduced cancerous cell death does not limit to the function of cell cycle arrest, the phytochemical compound also expressed the apoptotic effect through modulating gene expression of cancer cell line and induced degradation of cancerous cellular structure.
Additional evaluation of the phytochemical Epigallocatechin-3-gallate (EGCG) and the tumor suppressed drug miR-1 effect in osteosarcoma, researchers also found that Epigallocatechin-3-gallate has a profound and positive effect in improved the efficacy of miR-1 in induced cell apoptosis and proliferation observed in cancer cell lines MG-63 and U-2OS.
More importantly, MG-63 and U-2OS treated by miR-1 and Epigallocatechin-3-gallate (EGCG) decreased c-MET expression, which is an indication of cancers development.
Furthermore, the combined application of Epigallocatechin-3-gallate (EGCG) and c-MET inhibitor (crizotinib) also displayed significant inhibition of MG-63 and U-2OS cancer cell proliferation.
More interestingly, in the study of the effects of Se-enriched Ziyang green tea, containing chemical compound mannose, rhamnose and fucose in antitumor activity on human osteosarcoma U-2 OS cells in vitro and in vivo, researchers found that Se-ZYTP at concentration of 25, 50, 100 and 200 μg/ml exerted a significant inhibition of proliferation of human osteosarcoma U-2 OS cells in a concentration-dependent fashion.
In cancer cell line In U-2 OS cancer induced in BALB/c athymic mice model, Se-ZYTP oral administration at three doses of 100, 200 and 400mg/kg body weight (B.W.) daily for 28 days resulted in tumor regression as compared to model control without causing any serious side effects.
Once again, we illustrated that other chemical compounds found in green tea may also have the potential in the suppression of proliferation and induced apoptosis of osteosarcoma.
Indeed, the anti osteosarcoma activities of Se-enriched Ziyang green tea may be attributed to the stimulation in increased pro-apoptotic protein Bax expression(upregulated by the tumor suppressor protein p53 in induced apoptosis) and decreased expression levels of anti-apoptotic protein Bcl-2(regulator proteins that regulate cell death) and NG2(involved cell survival, migration, and angiogenesis), some researchers suggested.
Taking all together, green tea with plenty of phytochemicals in the suppression of the development and progression of cancer may be considered as an adjunct therapy in reduced risk and combination with chemo drugs for the treatment of osteosarcoma.
For More information about yoga lessons tailor to a complete well being for women, please visit: YOGA BURN
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) Overexpression of miR-126 sensitizes osteosarcoma cells to apoptosis induced by epigallocatechin-3-gallate by Jiang L, Tao C, He A, He X1.(PubMed)
92) Green tea polyphenol EGCG suppresses osteosarcoma cell growth through upregulating miR-1 by Zhu K1, Wang W2.(PubMed)
(3) Tumoricidal effects of a selenium (Se)-polysaccharide from Ziyang green tea on human osteosarcoma U-2 OS cells by Wang Y1, Chen J, Zhang D, Zhang Y, Wen Y, Li L, Zheng L.(PubMed)
Phytochemical Alliin, the Best Anti Metabolic Syndrome Remedy
Metabolic syndrome is a cluster of conditions that increase the risk of cardiovascular disease and diabetes, including too much fat around the waist, high blood pressure, triglycerides, and blood sugar, and low HDL cholesterol.
In other words, if you process 3 of the aforementioned conditions, you are at a higher risk of heart disease, stroke, and diabetes. However, most people with metabolic syndrome have never developed
CVD and diabetes.
Other than high blood glucose, induced thirst and urination, fatigue, and blurred vision, most patients with other metabolic conditions are asymptomatic.
Epidemiologically, aging, ethnicity, obesity, medical condition such as diabetes, nonalcoholic fatty liver disease, and polycystic ovary syndrome are most risk factors found in patients with the syndrome.
Some researchers suggested that the promotion of the Western diet in the US over the past few decades may have a strong effect in inducing the widespread metabolic syndrome.
Dr. Drake I, the lead scientist wrote, "The 'Western' dietary pattern was inversely associated with HDL-cholesterol and positively with all other response variables (both at baseline and follow-up), but there was no association with LDL at follow-up".
And, " In conclusion, this study supports current food-based dietary guidelines suggesting that a 'Western' dietary pattern with high intakes of sugar-sweetened beverages and red and processed meats and low intakes of wine, cheese, vegetables, and high-fiber foods is associated with detrimental effects on cardio-metabolic health".
The results clearly suggested that if you are following a traditional diet with high fruits and vegetable and fewer in processed food, saturated and trans fat, and red meat accompanied with moderate exercise daily, you are at substantially decreased risk metabolic syndrome, compared to those who follow the Western diet.
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
In the urgency to find a potential compound for the treatment of metabolic syndrome, researchers examined the pure allicin, prepared biosynthetically by reacting synthetic alliin with an immobilized alliinase enzyme in the protection against cardiovascular disease.
S-ally-mercapto captopril (CPSSA), a new stable synthetic compound produced by a chemical reaction between allicin and the angiotensin-converting enzyme inhibitor captopril was tested in a fructose-induced metabolic syndrome rat model.
Allicin (8 mg/(kg day)) used alone significantly reduced insulin, triglycerides, and homocysteine concentrations, and had a slight effect on SBP associated with the risk of metabolic syndrome.
On the other hand, Captopril (50mg/(kg day)) only improved blood pressure and homocysteine.
Treatment with a low dose of CPSSA (5mg/(kg day)) lowered SBP but did not improve any other measured parameter, while treatment with a higher dose Captopril (50mg/(kg day)) significantly decreased blood pressure, triglycerides, and homocysteine concentrations.
In other words, CPSSA exerted a strong anti-metabolic syndrome better than those of individual compound in a dose-dependent manner.
Based on the findings, researchers wrote, " the combined molecule CPSSA integrates the anti-hypertensive, lipid-lowering, and homocysteine-reducing effects of both allicin and captopril, making it a potential cardiovascular protective agent".
Taken altogether, alliin may be considered supplements for the prevention and treatment of metabolic syndrome, depending on the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The effects of S-ally-mercapto captopril, the synthetic product of allicin and captopril, on cardiovascular risk factors associated with the metabolic syndrome by Oron-Herman M1, Rosenthal T, Mirelman D, Miron T, Rabinkov A, Wilchek M, Sela BA. (PubMed)
(2) Role of phytochemicals in the management of metabolic syndrome by Cicero AF1, Colletti A. (PubMed)
(3) A Western dietary pattern is prospectively associated with cardio-metabolic traits and incidence of the metabolic syndrome by Drake I1, Sonestedt E1, Ericson U1, Wallström P2, Orho-Melander M. (PubMed)
In other words, if you process 3 of the aforementioned conditions, you are at a higher risk of heart disease, stroke, and diabetes. However, most people with metabolic syndrome have never developed
CVD and diabetes.
Other than high blood glucose, induced thirst and urination, fatigue, and blurred vision, most patients with other metabolic conditions are asymptomatic.
Epidemiologically, aging, ethnicity, obesity, medical condition such as diabetes, nonalcoholic fatty liver disease, and polycystic ovary syndrome are most risk factors found in patients with the syndrome.
Some researchers suggested that the promotion of the Western diet in the US over the past few decades may have a strong effect in inducing the widespread metabolic syndrome.
Dr. Drake I, the lead scientist wrote, "The 'Western' dietary pattern was inversely associated with HDL-cholesterol and positively with all other response variables (both at baseline and follow-up), but there was no association with LDL at follow-up".
And, " In conclusion, this study supports current food-based dietary guidelines suggesting that a 'Western' dietary pattern with high intakes of sugar-sweetened beverages and red and processed meats and low intakes of wine, cheese, vegetables, and high-fiber foods is associated with detrimental effects on cardio-metabolic health".
The results clearly suggested that if you are following a traditional diet with high fruits and vegetable and fewer in processed food, saturated and trans fat, and red meat accompanied with moderate exercise daily, you are at substantially decreased risk metabolic syndrome, compared to those who follow the Western diet.
Alliin (S-allyl-L-cysteine-S-oxide) is a phytochemical compound sulfoxide,. a derivative of the amino acid cysteine, belonging to the class of sulfur compounds, found abundantly in fresh garlic and onion.
In the urgency to find a potential compound for the treatment of metabolic syndrome, researchers examined the pure allicin, prepared biosynthetically by reacting synthetic alliin with an immobilized alliinase enzyme in the protection against cardiovascular disease.
S-ally-mercapto captopril (CPSSA), a new stable synthetic compound produced by a chemical reaction between allicin and the angiotensin-converting enzyme inhibitor captopril was tested in a fructose-induced metabolic syndrome rat model.
Allicin (8 mg/(kg day)) used alone significantly reduced insulin, triglycerides, and homocysteine concentrations, and had a slight effect on SBP associated with the risk of metabolic syndrome.
On the other hand, Captopril (50mg/(kg day)) only improved blood pressure and homocysteine.
Treatment with a low dose of CPSSA (5mg/(kg day)) lowered SBP but did not improve any other measured parameter, while treatment with a higher dose Captopril (50mg/(kg day)) significantly decreased blood pressure, triglycerides, and homocysteine concentrations.
In other words, CPSSA exerted a strong anti-metabolic syndrome better than those of individual compound in a dose-dependent manner.
Based on the findings, researchers wrote, " the combined molecule CPSSA integrates the anti-hypertensive, lipid-lowering, and homocysteine-reducing effects of both allicin and captopril, making it a potential cardiovascular protective agent".
Taken altogether, alliin may be considered supplements for the prevention and treatment of metabolic syndrome, depending on the confirmation of the larger sample size and multicenter human study.
Intake of alliin in the form of supplement should be taken with extreme care to prevent overdose acute liver toxicity.
Natural Medicine for Fatty Liver And Obesity Reversal - The Revolutionary Findings To Achieve Optimal Health And Lose Weight
How To Get Rid Of Eye Floaters
Contrary To Professionals Prediction, Floaters Can Be Cured Naturally
Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months
Back to Kyle J. Norton Homepage http://kylejnorton.blogspot.ca
Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.
Sources
(1) The effects of S-ally-mercapto captopril, the synthetic product of allicin and captopril, on cardiovascular risk factors associated with the metabolic syndrome by Oron-Herman M1, Rosenthal T, Mirelman D, Miron T, Rabinkov A, Wilchek M, Sela BA. (PubMed)
(2) Role of phytochemicals in the management of metabolic syndrome by Cicero AF1, Colletti A. (PubMed)
(3) A Western dietary pattern is prospectively associated with cardio-metabolic traits and incidence of the metabolic syndrome by Drake I1, Sonestedt E1, Ericson U1, Wallström P2, Orho-Melander M. (PubMed)
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