The Curable Smoothie of Ginger, Pineapple and Orange for Reduced Risk and Treatment of Lower Back Pain Back by Clinical trials and Studies of Respectable Institutions

Kyle J. Norton(Scholar, Master of Nutrients)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for reduced risk and treatment of Lower Back Pain

Yield: 2 serving (about 8 ounce each)
3/4 cup pineapple
3/4 cup orange
1 cup herbal ginger tea drink (Make from 4 grams(2 tea bags) of green tea, and a cup of hot water lipped for 5 minutes, and set aside for cooling to room temperature)


1. Place the grapes, green tea, in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The findings of a natural ingredient for treatment  of Lower Back Pain from scientific communities have not been abating. Many ingredients showed extremely prominent in animal studies do not produce the same effects in human trials.

According to the recent studies by the well known institutions, ginger(1), Pineapple(5) and orange(10), may hold a key for potential and therapeutic values for attenuated symptoms and treatment of lower back pain.

Ginger (Zingiber officinale) or ginger root is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil. It has been used in traditional and Chinese medicine to treat dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Strong evidence in pidemiological studies linking ginger phytochemicals in reduced symptoms of pain and treatment of chronic pain diseases may be due to its hypoalgesic and anti inflammatory activities(1)(4).

A 164 patients screened, 140 eligible, 70 were randomized to the application of aromatic ginger oil (SMGO) on chronic low back pain study, exhibited a significant improvements in pain intensity and disability (p<0.05) across the period of assessments in immediate, short- and long-term effectiveness(2).

According to the University of Freiburg im Breisgau, ginger has shown a moderate effect as a herbal medicine in the treatment of osteoarthritic complaints and chronic low back pain but further studies are necessary to enable acceptance of the herbal medicines into the treatment guidelines(3).

Intake of melatonin enhancer fruits, such as pineapple and orange can improve sleep quality, pain and pain threshold, particular on pain score on the Visual Analog Scale, according to the study by the Universidade Federal do Rio Grande do Sul (UFRGS)(5).

In chronic lower back pain patient, Dr. Kurganova YM and Dr. Danilov AB. said, in application over 12 weeks of melatonin in patient with lower back pain " (there is) a significant reduction in pain intensity at movement and resting state.....in the main groups compared to controls" and " ossible mechanisms of analgesic properties of melatonin and world experience in chronic low back pain treatment"(6). Other study suggested that the effectiveness of melatonin in pain relief in chronic pain patient, probably due to its analgesic possibilities(7).

According to the Ubon Ratchathani University, intake of pineapple and orange in health subjects experiment showed to increase the serum melatonin concentrations as well as raising the antioxidant capacity in proportion to serum melatonin levels(8). 

Pineapple is a species of Ananas Comos. belongings to the family Bromeliaceae and native to southern Brazil and Paraguay. Today it is widely cultivated for commercial and its rich of vitamins and mineral and digesting enzyme bromelin which seems to help digestion at the end of a high protein meal. It is second only to banana as America's most favourite tropical fruit

Dr. Johns NP and colleagues at the Khon Kaen University said," selected fruits(pineapple, orange and banana) consumption may reduce age-related melatonin reduction problems such as sleeplessness and illnesses involving oxidative damage"(9).

Orange is a species of Citrus Sinensis, belong to the family Rutaceae and native to the Southeast Asia. Orange is round citrus fruits with finely-textured skins, orange in color and one of most popular fruits in the world.

The increased levels of melatonin content during alcoholic fermentation of orange juice may hold a key to attenuate the melatonin due to ageing(10).

Dr. Huang X and Dr. Mazza G. said," orange had the highest melatonin content" in the the direct analysis of initial methanol extracts was compared with further ethyl acetate extraction(11).

Taking altogether, intake of combination of ginger, pineapple and orange  induced the production of melatonin in improved the sleep pattern and reduced significantly pain on pain score may be beneficiary for treatment of symptoms of  lower back pain

People who are at higher risk of lower back pain due to aging or occupations,...may drink one or 2 servings a day, people with lower back pain should drink as much as they can depending to the digestive alternation.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

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References

(1) Ginger (Zingiber officinale) reduces muscle pain caused by eccentric exercise by Black CD1, Herring MP, Hurley DJ, O'Connor PJ.(PubMed)

(2) The effectiveness of Swedish massage with aromatic ginger oil in treating chronic low back pain in older adults: a randomized controlled trial by Sritoomma N1, Moyle W2, Cooke M3, O'Dwyer S4.(PubMed)

(3) Evidence of effectiveness of herbal antiinflammatory drugs in the treatment of painful osteoarthritis and chroniclow back pain by Chrubasik JE1, Roufogalis BD, Chrubasik S.(PubMed)

(4) Acute effects of dietary ginger on muscle pain induced by eccentric exercise by Black CD1, O'Connor PJ.(PubMed)
(5) Melatonin analgesia is associated with improvement of the descending endogenous pain-modulating system infibromyalgia: a phase II, randomized, double-dummy, controlled trial BY de Zanette SA, Vercelino R, Laste G, Rozisky JR, Schwertner A, Machado CB, Xavier F, de Souza IC, Deitos A, Torres IL, Caumo W1.(PubMed)
(6) [A role of melatonin in the treatment of low back pain].[Article in Russian] by Kurganova YM, Danilov AB(PubMed)
(7) [Melatonin and pain].[Article in Russian] by Kurganova IuM, Danilov AB, Goriachev DV.(PubMed)
(8) Serum melatonin levels and antioxidant capacities after consumption of pineapple, orange, or banana by healthy male volunteers by Sae-Teaw M1, Johns J, Johns NP, Subongkot S.(PubMed)
(9) Dietary intake of melatonin from tropical fruit altered urinary excretion of 6-sulfatoxymelatonin in healthy volunteers by Johns NP1, Johns J, Porasuphatana S, Plaimee P, Sae-Teaw M.(PubMed)
(10) Alcoholic fermentation induces melatonin synthesis in orange juice by Fernández-Pachón MS1, Medina S, Herrero-Martín G, Cerrillo I, Berná G, Escudero-López B, Ferreres F, Martín F, García-Parrilla MC, Gil-Izquierdo A.(PubMed)
(11) Simultaneous analysis of serotonin, melatonin, piceid and resveratrol in fruits using liquid chromatography tandem mass spectrometry by Huang X1, Mazza G.(PubMed)

Most Common Diseases of elder: Respiratory Disease: Asthma Treatment: The Important Folate

Kyle J. Norton(Scholar and Master of Nutrients)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Respiratory Disease is defined as medical conditions which affect the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.

                                  Asthma

Asthma is a chronic inflammatory disease affecting the air way of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages, and mostly starts during childhood. In the study of 463,801 children aged 13-14 years in 155 collaborating centres in 56 countries. Children self-reported, through one-page questionnaires, symptoms of these three atopic disorders. In 99 centres in 42 countries, a video asthma questionnaire was also used for 304,796 children, found that for asthma symptoms, the highest 12-month prevalences were from centres in the UK, Australia, New Zealand, and Republic of Ireland, followed by most centres in North, Central, and South America; the lowest prevalences were from centres in several Eastern European countries, Indonesia, Greece, China, Taiwan, Uzbekistan, India, and Ethiopia(1). In the United States, approximately, asthma affects 25 million people, 7 million of them are children.

                   The Effectiveness of Folate

Folate, also known as folic acid, vitamin B9, is a water soluble vitamin, found abundantly in leafy vegetables, citrus fruits, beans, whole grain, etc. The vitamin plays an important role in synthesize DNA, repair DNA, and methylate DNA as well as to act as a cofactor in certain biological reactions, production of red blood cells for anemia prevention.

1. Serum levels of folate
Scientific studies, serum levels of folate may associate to risk of asthma. The study by Ain Shams University showed that serum folate levels are significantly lower among atopics, and correlate inversely with the degree of atopy among asthmatics(1). Other researchers suggested that low serum folate and impaired folate metabolism may be a potential risk factors for development of asthma and atopic disease. According to The Capital Region of Denmark, in a random sample of 6784 persons from a general population aged 30-60 years participated in a health examination in 1999-2001, low levels of serum of folate were associated with self-reported doctor-diagnosedasthma and attacks of shortness of breath, but not with lung function or atopy(2). The Johns Hopkins School of Medicine study also indicated that the effects of serum levels of folate were associated inversely associated with high total IgE levels, atopy, and wheeze(3).

2. The effects of folate in maternal intake
Folic acid supplementation has an established role in early pregnancy for preventing neural tube defects, but its causes of childhood asthma and asthmatic symptoms in epidemiological studies have been inconclusive. According to the University of Western Australia, maternal folic acid exposure may be associated to childhood asthma and wheeze(4). Other in the study of pre-natal FACSs exposure population showed a small increased risk of early wheeze, but no adverse association of respiratory or allergic outcomes(5). In the study using the data from an Australian prospective birth cohort study (n = 557) from 1998 to 2005. At 3.5 years and 5.5 years, 490 and 423 mothers and children participation, researchers at the The University of Adelaide, indicated the correlation of the supplementation with folate in pregnancy and incidence of childhood allergic asthma through epigenetic mechanisms and also associated with poorer respiratory outcomes in young children(6).

Since the search of the effect of folate intake in reduced risk and treatment of asthma have produced limitation of result, we concluded that folate deficiency or low levels of folate may be associated to increased risk of early onset of the disease, but multi centers and large sample size studies are necessary to improve its validation. Overdoses of folate may cause stomach problems, sleep problems, skin reactions, seizures, etc., please make sure you follow the guideline of the Institute of Medicine of the National Academies.


All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offer recommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(1) Study of folate status among Egyptian asthmatics by Farres MN1, Shahin RY, Melek NA, El-Kabarity RH, Arafa NA.(PubMed)
(2) Atopy, asthma, and lung function in relation to folate and vitamin B(12) in adults by Thuesen BH1, Husemoen LL, Ovesen L, Jørgensen T, Fenger M, Gilderson G, Linneberg A.(PubMed)
(3) Higher serum folate levels are associated with a lower risk of atopy and wheeze by Matsui EC1, Matsui W.(PubMed)
(4) Folic acid in pregnancy - is there a link with childhood asthma or wheeze? by Sharland E1, Montgomery B, Granell R.(PubMed)
(5) Maternal use of folic acid supplements during pregnancy, and childhood respiratory health and atopy by Bekkers MB1, Elstgeest LE, Scholtens S, Haveman-Nies A, de Jongste JC, Kerkhof M, Koppelman GH, Gehring U, Smit HA, Wijga AH.(PubMed)
(6) Effect of supplemental folic acid in pregnancy on childhood asthma: a prospective birth cohort study by Whitrow MJ1, Moore VM, Rumbold AR, Davies MJ.(PubMed)

The Tasty Green tea, Grape and Asparagus for reduced risk and treatment of Gout

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


The smoothie for reduced risk and Treatment of Gout
Yield: 2 serving (about 8 ounce each)
1 1/4 cups grape

1/4 cup asparagus
1 cup green tea drink (Make from 4 grams of green tea, and a cup of hot water lipped for 5 minutes. Set aside for cooling to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding the natural ingredients for treatment of Gout is considered as a dream of many scientist to replace the long usage adverse effect of conventional medicine to other organs in the body.
Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center.

Recent studies suggested that scientist in some research centers have found the naturally potential ingredients, such as green tea(1), Grape(4) and Asparagus(7) for reduced risk and treatment for gout.

Gout mostly effected one joint is defined as a acute and recurrent condition of arthritis as a result of uric acid builds up in blood cause of joint inflammation.

Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years.Green tea glycosides, including quercetin and rutin applied to orally to the oxonate-induced hyperuricemic mice 3 time a day, exhibited the anti xanthine dehydrogenase/xanthine oxidase (XDH/XO), the cofactors to produce uric acid activities(1).

According to the Chiang Mai University, green tea extract (GTE) also promoted hypouricemic and anti gout effects through modestly lowering serum uric acid (SUA) level and decreasing uric acid clearance(2).

A randomly stratified cluster sampling conducted with 7403 inhabitants aged over 20 years in Foshan areas, suggested that intake of green tea is found to associated to reduced risk of gout. Reduced intake of food with rich purine, alcohol intake as well as controlling obesity and blood pressure, improving the status of lipid metabolic disorder together with programs as hypertension control etc.(3).

Grape is a woody vines of the genus Vitis, belong to the family Vitaceae, native to southern Turkey. Its phytochemical resveratrol (RSV) has found to reduce risk and treatment of gout in traditional medicine(4).

According to the Osaka University, resveratrol (RSV) also inhibits NLRP3-inflammasome (inflammatory cytokines)activation and mediate the immune responses causes inflammatory diseases, including gout(5).

Dr. Wang Y and colleagues at the Nanjing University said,"procyanidins from grape seeds possess in vivo urate-lowering activities"(6).

Asparagus is a flowering plant belongings to species the genus Asparagus, native to the western coasts of northern Spain, north to Ireland, Great Britain, and northwest Germany, northern Africa and western Asia. Asparagus has been used from early times as a vegetable and medicine, because of its delicate flavour and diuretic properties.

Crude saponin extracts from asparagus used in the treatment of rheumatoid arthritis, gout and haemorrhoids in Nigerian medicinal plants, probably doe to their anti inflammatory diseases activities(8).

According to Dr. Nile SH and vDr. Park SW, The total phenolic and flavonoid from asparagus extract exhibited significant xanthine oxidase inhibitory activity in related to production of uric acids in inducing the risk of gout(7).

These finding of the effectiveness of Green Tea, Grape and Asparagus  may serve as cornerstones of pharmaceutical target for further studies as well as a potential medication for treatment of Gout without adverse effects.

People who are at high risk of gout such as family history,.....should drink at least one cup daily and people with gout should drink the juices as much as they can, depending to digestive toleration.

Change of life style and diet pattern are also recommended.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offerrecommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References

(1) Effects of Biota orientalis extract and its flavonoid constituents, quercetin and rutin on serum uric acid levels in oxonate-induced mice and xanthine dehydrogenase and xanthine oxidase activities in mouse liver by Zhu JX1, Wang Y, Kong LD, Yang C, Zhang X.(PubMed)

(2) Effects of green tea extract on serum uric acid and urate clearance in healthy individuals by Jatuworapruk K1, Srichairatanakool S, Ounjaijean S, Kasitanon N, Wangkaew S, Louthrenoo W.(PubMed)

(3) [Epidemiological study on hyperuricemia and gout in Foshan areas, Guangdong province.][Article in Chinese] by Yu JW1, Yang TG, Diao WX, Cai XQ, Li T, Zhong H, Hu DL, Chen CQ, Chen ZX.(PubMed)
(4) Effects of resveratrol on collagen type II protein in the superficial and middle zone chondrocytes of porcine articular cartilage by Maepa M1, Razwinani M1, Motaung S1.(PubMed)
(5) Resveratrol inhibits the acetylated α-tubulin-mediated assembly of the NLRP3-inflammasome. by Misawa T1, Saitoh T1, Kozaki T1, Park S1, Takahama M1, Akira S1.(PubMed)
(6) Administration of procyanidins from grape seeds reduces serum uric acid levels and decreases hepatic xanthine dehydrogenase/oxidase activities in oxonate-treated mice by Wang Y1, Zhu JX, Kong LD, Yang C, Cheng CH, Zhang X.(PubMed)
(7) HPTLC Analysis, Antioxidant and Antigout Activity of Indian Plants by Nile SH1, Park SW1.(PubMed)

Most Common Diseases of elder: Respiratory Disease: Asthma Treatment: The Important Vitamin K

Kyle J. Norton(Scholar and Master of Nutrients)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Respiratory Disease is defined as medical conditions which affect the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.

                                  Asthma

Asthma is a chronic inflammatory disease affecting the air way of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages, and mostly starts during childhood. In the study of 463,801 children aged 13-14 years in 155 collaborating centres in 56 countries. Children self-reported, through one-page questionnaires, symptoms of these three atopic disorders. In 99 centres in 42 countries, a video asthma questionnaire was also used for 304,796 children, found that for asthma symptoms, the highest 12-month prevalences were from centres in the UK, Australia, New Zealand, and Republic of Ireland, followed by most centres in North, Central, and South America; the lowest prevalences were from centres in several Eastern European countries, Indonesia, Greece, China, Taiwan, Uzbekistan, India, and Ethiopia(1). In the United States, approximately, asthma affects 25 million people, 7 million of them are children.

                   The Effectiveness of Vitamin K

Vitamin K(K1, phylloquinone; K2, menaquinones), is a fat soluble vitamin, found abundantly in leafy green vegetables, broccoli, and Brussels sprouts, etc. It is best known for promotion of coagulation and bone health.
Epidemiological studies focusing vitamin K in reduced risk and treatment of asthma have been inconclusive(a)(b)(c).

Menaquinone (vitamin K2), a variant of vitamin K, in a double blind study of 191 patients with bronchial asthma, showed an effective rate of 90.9% in mild patients, 86.7% in moderate patients, and 72.7% in severe patients(1). Other researchers suggested that treatment of menaquinone for long periods in patients with bronchial asthma indicated a significant inhibition of the disease(2). The data base of PubMed showed limitation in quantity of the research, we, therefore make no conclusion of the effectiveness of the vitamin in reduced risk and treatment of asthma. Overdoses can induce symptoms of Skin rash, Diarrhea, Nausea, Vomiting, Anemia, etc. Please make sure you follow the guideline of the Institute of Medicine of the National Academies.


All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offerrecommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(a) Maternal intake of vitamins A, E and K in pregnancy and child allergic disease: a longitudinal study from the Danish National Birth Cohort by Maslova E, Hansen S, Strøm M, Halldorsson TI, Olsen SF.(PubMed)
(b) Fat-soluble vitamins and atopic disease: what is the evidence? by Litonjua AA.(PubMed)
(c) [Antioxidant and fat intake in patients with polinic asthma].[Article in Spanish] by de Luis DA1, Izaola O, Aller R, Armentia A, Cuéllar L.(PubMed)
(1) Menaquinone (vitamin K2) therapy for bronchial asthma. II. Clinical effect of menaquinone on bronchial asthma by Kimur I, Tanizaki Y, Sato S, Saito K, Takahashi K.(PubMed)
(2) Menaquinone (vitamin K2) therapy for bronchial asthma. I. Mechanism of action menaquinone on allergic reactions by Kimura I, Tanizaki Y, Sato S, Saito K, Takahashi K.(PubMed)

The smoothie of Green Tea, Grape and Pumpkin for Prevention and Treatment of Polymyalgia Rheumatica(PMR) Back by Renowned Institution

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


The smoothie for people with high risk Polymyalgia Rheumatica and Polymyalgia Rheumatica
Yield: 2 serving (about 8 ounce each)
1 1/4 cups grape

1/4 cup pumpkin
1 cup green tea drink (Make from 4 grams of green tea, and a cup of hot water lipped for 5 minutes. Set aside for cooling to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding the natural ingredients for improvement of Polymyalgia Rheumatica is considered as a dream of many scientist. Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center. Some even produce conflicted results in second and further studies.

Scientist at the some research centers may have found the way to reduce risk and treatment of inflammatory rheumatic disease such as Polymalagia Arthritis. Green tea(1), Grape(1) and pumpkins(1) may be one of the findings with potential and pharmaceutical ingredients.

Polymalagia Arthritis is defined as a condition a common inflammatory rheumatic disease which cause pain, stiffness and tenderness in large muscles, including muscles shoulders and pelvic girdleas a result of the presence of a synovitis in proximal joints and periarticular structures, causing musculoskeletal symptoms in PMR.

Green tea, is a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. Its flavonoids play an important role in expression of antioxidative, anti-inflammatory and anti-neoplastic activities against chronic inflammatory diseases, including PMR through inhibiting the disorders induced by inflammatory pathways(2).

According to the Banaras Hindu University, (-)-epigallocatechin-3-gallate (EGCG), the predominant green tea polyphenol also inhibits enzyme activities and signal transduction of DNA is transferred from one bacterium to another by a virus pathways related to the inflammation and joint destruction in arthritis(3).

Resveratrol (RES), is a well-known antioxidant and anti-inflammatory compound found abundantly in grapes.

Use conjunction with Norisoboldine (NOR), the combination attenuated OC differentiation and bone erosion through the activation of AhR in bone regulation and the subsequent inhibition of NF-κB and proinlammatory pathways(4), according to the China Pharmaceutical University.

Also when use together with curcumin, the combination expressed a remarkable anti-inflammatory activity with inhibition of 37-55% arthritis induction between day 16 and 22(5).
Dr. Wang P and colleagues at the Chengyang People's Hospital of Qingdao City said," Resveratrol has been shown to exert anti-inflammatory and antioxidant effects, while sodium alginate is a common pharmaceutic adjuvant with antioxidative and immunomodulatory properties" in the study of resveratrol on acute gouty arthritis(6).

Pumpkin is the genus Cucurbita and belong the family Cucurbitaceae. The origin of pumpkins is unknown, although many people believe that they have originated in North America. Its phytochemical, cucurbitacins have exhibited the anti inflammatory diseases and may also be used for reduced risk and treatment of Polymyalgia Rheumatica(PMR)(1).

According to the Cairo University, Cairo University, cucurbitacins found in Iberis amara, extract promotes anti rheumatic inflammatory conditions to help safeguard the integrity of the endothelium and reduces the risk of vascular complications(7).

The University of South of Santa Catarina study also lend a support of anti inflammatory effect of cucurbitacins through suppressing the COX-2 proinflammatory cytokines(8).

In animal model, Dr. Escandell JM and the research team at the Universitat de València said," experimental data on the chronic model, together with previously reported activity on acute and subchronic experimental models, justify the anti-inflammatory activity of cucurbitacin R and provide further evidence for the therapeutic potential of a group of natural products as anti-inflammatory agents"(9).

People who are at increased risk of Polymyalgia Rheumatica(PMR) due to aging, occupations, family history, gene mutation,....should drink at least one cup daily and people with Polymyalgia Rheumatica(PMR) should drink the smoothie as much as they can, depending to digestive and liver toleration.

Change of life style and diet pattern are also recommended.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offerrecommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References

(1) Anti-inflammatory agents from plants: progress and potential by Recio MC1, Andujar I, Rios JL.(PubMed)

(2) [Anti-inflammatory effects of tea-flavonoids].[Article in German] by Hoensch H1, Oertel R.(PubMed)

(3) Green tea polyphenol epigallocatechin-3-gallate: inflammation and arthritis. [corrected]. by Singh R1, Akhtar N, Haqqi TM.(PubMed)

(4) Norisoboldine, an Anti-Arthritis Alkaloid Isolated from Radix Linderae, Attenuates Osteoclast Differentiation andInflammatory Bone Erosion in an Aryl Hydrocarbon Receptor-Dependent Manner by Wei ZF1, Lv Q1, Xia Y1, Yue MF1, Shi C1, Xia YF1, Chou GX2, Wang ZT2, Dai Y1.(PubMed)

(5) A novel approach to arthritis treatment based on resveratrol and curcumin co-encapsulated in lipid-core nanocapsules: In vivo studies by Coradini K1, Friedrich RB1, Fonseca FN1, Vencato MS2, Andrade DF1, Oliveira CM3, Battistel AP3, Guterres SS1, da Rocha MI2, Pohlmann AR4, Beck RC5.(PubMed)

(6) Effect of sodium alginate addition to resveratrol on acute gouty arthritis by Wang P1, Ren D, Chen Y, Jiang M, Wang R, Wang YG.(PubMed)

(7) Mechanisms Involved in the Anti-inflammatory and Vascular Effects of Iberis amara Extract by Khayyal MT1, Agha AM1, Zaki HF1, El-Sahar A1, Abdel-Aziz H2.(PubMed)

(8) Nitric oxide and cyclooxygenase may participate in the analgesic and anti-inflammatory effect of the cucurbitacins fraction from Wilbrandia ebracteata by Peters RR1, Baier Krepsky P, Siqueira-Junior J, da Silva Rocha JC, Marques Bezerra M, de Albuquerque Ribeiro R, de Brum-Fernandes AJ, Rocha Farias M,Castro da Rocha FA, Ribeiro-do-Valle RM.(PubMed)

(9) Cucurbitacin R reduces the inflammation and bone damage associated with adjuvant arthritis in lewis rats by suppression of tumor necrosis factor-alpha in T lymphocytes and macrophages. by Escandell JM1, Recio MC, Máñez S, Giner RM, Cerdá-Nicolás M, Ríos JL.(PubMed)

Most Common Diseases of elder: Respiratory Disease: Asthma Treatment: The Effectiveness of Vitamin D

Kyle J. Norton(Scholar and Master of Nutrients)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Respiratory Disease is defined as medical conditions which affect the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.

                                  Asthma

Asthma is a chronic inflammatory disease affecting the air way of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages, and mostly starts during childhood. In the study of 463,801 children aged 13-14 years in 155 collaborating centres in 56 countries. Children self-reported, through one-page questionnaires, symptoms of these three atopic disorders. In 99 centres in 42 countries, a video asthma questionnaire was also used for 304,796 children, found that for asthma symptoms, the highest 12-month prevalences were from centres in the UK, Australia, New Zealand, and Republic of Ireland, followed by most centres in North, Central, and South America; the lowest prevalences were from centres in several Eastern European countries, Indonesia, Greece, China, Taiwan, Uzbekistan, India, and Ethiopia(1). In the United States, approximately, asthma affects 25 million people, 7 million of them are children.

                   The Effectiveness of Vitamin D

Vitamin D is a fat-soluble secosteroids found in small amount in few foods, including salmon, mackerel, sardines and tuna. The vitamin plays an important role in modulation of cellular proliferation, apoptosis induction, tumor growth suppression and promotion in absorption of minerals, including calcium, iron, magnesium, phosphate and zinc.

1. Serum of vitamin D
Epidemiological studies, linking the levels of serum 25-OH vitamin D withasthma may be inconclusive. The study of included 4,999 adults aged 30-60 years in 1999-2001. 3,032 of those included at baseline also participated at a follow-up examination 5 years later and 3,727 answered a 10 year follow-up questionnaire, showed no association of serum serum 25-OH vitamin D and the risk of asthma in Danish adults(1)(1a). Some researchers in the study of general Korean population suggested that vitamin D-insufficiency may have an increased likelihood of atopic dermatitis, but not asthma, allergic rhinitis, or IgE sensitization(2)(2a). But the study by Royal Brompton Hospital, London indicated otherwise of relationships between serum vitamin D, lung function, and pathology in children with severe, therapy-resistant asthma(STRA)(3)(4) and 25 hydroxy vitamin D insufficiency wass associated with bronchial asthma(4a) On the other hand, the study of iMayo Clinic indicated the correlation between serum 25(OH)D concentrations and positive pneumococcal antibody levels in all subjects regardless of asthma(5).

2. The benefits
According to the study by Universitätsmedizin Berlin, oral administration of vitamin D in vitamin D deficiency induced asthma, showed an increased expression of CD38 on B cells and a decreased T-cell-dependent proinflammatory cytokine production(6). In support to above study, Vitamin D found to decreased inflammatory cytokine production from T-cell subsets implicated in asthma, according to Florida Atlantic University(7). In patient with steroid-resistant (SR) and steroid-sensitive (SS) asthma, oral administration of vitamin D, although exerted its anti-inflammatory and corticosteroid-enhancing effects in monocytes of patients with SR asthmaand patients with SS asthma, the responses to corticosteroids in patients with SR asthma remained significantly lower than those in patients with SSasthma(8). Other in the study of the effect of vitamin D in severe therapy-resistant asthma (STRA) patients, showed an positive effect of 1α,25-dihydroxyvitamin D3, the active form of vitamin D in culture enhanced dexamethasone-induced IL-10 (Defective IL-10 expression causes a significantly diminished levels of anti-inflammatory interleukin (IL)-10))without marked effects on IL-13 or IL-17A production(9). Patients with severe asthmaexhibited increased levels of TH17 cytokines.The study of King's College London, also suggested that 1,25(OH)2D3 inhibits TH17 cytokine production in all patients with moderate-to-severe asthma(10), enhances the frequency of Treg cells(11)and upregulates CD200 on peripheral human CD4+ T cells(12).

Taken altogether, without going into reviews, vitamin D used conjunction with other anti asthma medicine and its the active form 1α,25-dihydroxyvitamin D3, may be associated to reduced risk and treatment of asthmatic diseases. Over doses of vitamin D supplement may cause excessive calcium absorption, calcification, Urinary stones etc. please make sure to follow the guideline of the Institute of Medicine of the National Academies.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(1) The association of serum 25-OH vitamin D with atopy, asthma, and lung function in a prospective study of Danish adults by Thuesen BH1, Skaaby T, Husemoen LL, Fenger M, Jørgensen T, Linneberg A.(PubMed)
(1a) Vitamin d in pediatric inpatients with respiratory illnesses by Iqbal S1, Mosenkis EV, Jain P, Wiles A, Lerner J, Benton AS, Chamberlain JM, Freishtat RJ, Teach SJ.(PubMed)
(2) Low vitamin D levels are associated with atopic dermatitis, but not allergic rhinitis, asthma, or IgE sensitization, in the adult Korean population by Cheng HM1, Kim S2, Park GH3, Chang SE4, Bang S5, Won CH4, Lee MW4, Choi JH4, Moon KC(PubMed)
(2a) Vitamin D with asthma and COPD: not a false hope? A systematic review and meta-analysis By Zhang LL1, Gong J2, Liu CT3.(PubMed)
(3) Childhood asthma and vitamin D deficiency in Turkey: is there cause and effect relationship between them? Uysalol M1, Mutlu LC, Saracoglu GV, Karasu E, Guzel S, Kayaoglu S, Uzel N.(PubMed)
(4) Relationship between serum vitamin D, disease severity, and airway remodeling in children with asthma by Gupta A1, Sjoukes A, Richards D, Banya W, Hawrylowicz C, Bush A, Saglani S.(PubMed)
(4a) Serum 25 Hydroxy Vitamin D Insufficiency Associated with BronchialAsthma in Lucknow, India by Awasthi S1, Vikram K.(PubMed)
(5) Serum 25-hydroxyvitamin D is associated with enhanced pneumococcal antibody levels in individuals with asthma by Lee J1, Zhao H, Fenta Y, Kita H, Kumar R, Juhn YJ.(PubMed)
(6) Oral vitamin D increases the frequencies of CD38+ human B cells and ameliorates IL-17-producing T cells by Drozdenko G1, Heine G, Worm M.(PubMed)
(7) Effect of vitamin D on T-helper type 9 polarized human memory cells in chronic persistent asthma by Keating P1, Munim A2, Hartmann JX2.(PubMed)
(8) Anti-inflammatory and corticosteroid-enhancing actions of vitamin D in monocytes of patients with steroid-resistant and those with steroid-sensitiveasthma by Zhang Y1, Leung DY2, Goleva E3.(PubMed)
(9) Defective IL-10 expression and in vitro steroid-induced IL-17A in paediatric severe therapy-resistant asthma by Gupta A1, Dimeloe S, Richards DF, Chambers ES, Black C, Urry Z, Ryanna K, Xystrakis E, Bush A, Saglani S, Hawrylowicz CM.(PubMed)
(10) Enhanced production of IL-17A in patients with severe asthma is inhibited by 1α,25-dihydroxyvitamin D3 in a glucocorticoid-independent fashion by Nanzer AM1, Chambers ES, Ryanna K, Richards DF, Black C, Timms PM, Martineau AR, Griffiths CJ, Corrigan CJ, Hawrylowicz CM.(PubMed)
(11) The role of 1α,25-dihydroxyvitamin D3 and cytokines in the promotion of distinct Foxp3+ and IL-10+ CD4+ T cells by Urry Z1, Chambers ES, Xystrakis E, Dimeloe S, Richards DF, Gabryšová L, Christensen J, Gupta A, Saglani S, Bush A, O'Garra A, Brown Z, Hawrylowicz CM.(PubMed)
(12) 1α,25-dihydroxyvitamin D3 promotes CD200 expression by human peripheral and airway-resident T cells by Dimeloe S1, Richards DF, Urry ZL, Gupta A, Stratigou V, Farooque S, Saglani S, Bush A, Hawrylowicz CM.(PubMed)

Posted by kyle J. Norton at 0

The curable Smoothie of Green Tea, Grape and Orange for Reduced Risk and Treatment of Rheumatoid Arthritis(RA) back by Clinical Trials and Studies of Respectable Institutions

Kyle J. Norton(Scholar, master of nutrients), all right reserved
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for people with Rheumatoid Arthritis and high risk of the disease

Yield: 2 serving (about 8 ounce each)
3/4  cup grape
3/4 cup orange
1 cup green tea drink (Make from 4 grams of green tea, and a cup of hot water lipped for 5 minutes. Set aside for cooling to room temperature)

1. Place tall ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for reduced risk and treatment of Rheumatoid Arthritis has encountered many obstacles, many ingredients showed initially the promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.

Rheumatoid Arthritis is defined a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body. The disease affects more women than men and generally occurs after the ages of 40, causing the diminished quality of life of many elders.

Green Tea Epigallocatechin-3-Gallate(1)Grape(5) and Orange(10), may be next generation of pharmaceutical ingredients for reduced risk and treatment of Rheumatoid Arthritis due to their effects in suppressing autoimmunity. According to the joint studu lead by the University of Texas Southwestern Medical Center, the polyphenol (-)-epigallocatechin-3-gallate (EGCG), EGCG significantly suppressed T cell proliferation and relative frequencies of CD4 T cells, CD8 T cells and B cell subsets through mediated the immunoregulation(1).

In rats with adjuvant-induced arthritis, green tea treatment effectively normalized the activity of glucose 6-phosphate dehydrogenase, a key enzyme of an important metabolic route (pentose monophosphate pathway) that are substantially modified by arthritis(2).

Dr. Ramadan G and colleagues in the expression of green tea used for treatment against inflammatory diseases including Rheumatoid Arthritis suggested that the potent of green tea in reduced inflammtory expression may be due to its inhibition of proinflammatory activities(3).
Furthermore, green tea extract (GTE) aslo was found effectively in regulating chemokine production and chemokine receptor expression in human RA synovial fibroblasts and rat adjuvant-induced arthritis (AIA), through expression of anti inflammatory cytokines pathways(4).

Intake of grape with abundant quercetin, resveratrol and procyanidins may be able to modulate chronic inflammatory diseases including rheumatoid arthritis, inflammatory bowel disease,....(5). 

Resveratrol is best known to consist significant anti-inflammatory effects on AA rats, which may be associated with the reduction of COX-2 and PGE2 inflammatory mediators(8)..

According to the Hyogo College of Medicine, resveratrol induces apoptosis MH7A human rheumatoid arthritis synovial cells by activating caspase-9( in apoptosis and cytokine processing) and the effector caspase-3(responsible for apoptosis execution) along mitochondrial disruption(6).

Vam3, a derivative of resveratrol was found to interact with spleen tyrosine kinase (SYK) which plays a crucial role in adaptive immune receptor signalling, according to the joint study lead by the Peking Union Medical College, in extracellular antigen-induced crosslinking of type of antibody in the pathogenesis of autoimmune disorders, such as rheumatoid arthritis(7).

Orange is a species of Citrus Sinensis, belong to the family Rutaceae and native to the Southeast Asia. Orange is round citrus fruits with finely-textured skins, orange in color and one of most popular fruits in the world. Chronic intake of citrus fruits is found to associate to lower RA risk(10)

According to the Iwaki Meisei University, Orange flavanone naringin showed effectively in inhibit the inflammatory responses in mice with collagen-induced arthritis (CIA), a mouse model for RA(9).
In collagen-induced arthritic mice, nobiletin found abundantly in orange and other citrus fruits effectively interferes with gene expression of ADAMTS-4 and -5(inflammatory regulated enzymes ), and thereby prevents cartilage destruction in CIA mice(11).

Taking altogether, people who are at increased of Rheumatoid Arthritis(RA) due to family history, gene mutation,....should drink at least one cup daily and people with Rheumatoid Arthritis(RA) should drink the smoothie as much as they can, depending to digestive and liver toleration.

Change life style and diet pattern are also recommended.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References

(1) Green Tea Epigallocatechin-3-Gallate Suppresses Autoimmune Arthritis Through Indoleamine-2,3-Dioxygenase Expressing Dendritic Cells and the Nuclear Factor, Erythroid 2-Like 2 Antioxidant Pathway by Min SY1, Yan M1, Kim SB2, Ravikumar S3, Kwon SR4, Vanarsa K3, Kim HY5, Davis LS1, Mohan C3.(PubMed)

(2) Green tea extract improves the oxidative state of the liver and brain in rats with adjuvant-induced arthritis by de Almeida Gonçalves G1, de Sá-Nakanishi AB, Wendt MM, Comar JF, Bersani Amado CA, Bracht A, Peralta RM.(PubMed)

(3) Anti-inflammatory activity of green versus black tea aqueous extract in a rat model of human rheumatoid arthritis by Ramadan G1, El-Beih NM1, Talaat RM2, Abd El-Ghffar EA1.(PubMed)

(4) Green tea extract inhibits chemokine production, but up-regulates chemokine receptor expression, in rheumatoid arthritis synovial fibroblasts and rat adjuvant-induced arthritis by Marotte H1, Ruth JH, Campbell PL, Koch AE, Ahmed S.(PubMed)

(5) Effects of antioxidant polyphenols on TNF-alpha-related diseases by Kawaguchi K1, Matsumoto T, Kumazawa Y.(PubMed)

(6) Resveratrol induces apoptosis MH7A human rheumatoid arthritis synovial cells in a sirtuin 1-dependent manner by Nakayama H1, Yaguchi T, Yoshiya S, Nishizaki T.(PubMed)

(7) A combined experimental and computational study of Vam3, a derivative of resveratrol, and Syk interaction by Jiang M1, Liu R2, Chen Y3, Zheng Q4, Fan S5, Liu P6.(PubMed)

(8) Anti-inflammatory effect of resveratrol on adjuvant arthritis rats with abnormal immunological function via the reduction of cyclooxygenase-2 and prostaglandin E2 by Chen X1, Lu J1, An M1, Ma Z1, Zong H1, Yang J1.(PubMed)

(9) Suppression of inflammatory responses after onset of collagen-induced arthritis in mice by oral administration of the Citrus flavanone naringin by Kawaguchi K1, Maruyama H, Hasunuma R, Kumazawa Y.(PubMed)

(10) Effects of antioxidant polyphenols on TNF-alpha-related diseases by Kawaguchi K1, Matsumoto T, Kumazawa Y.(PubMed)

(11) Nobiletin, a citrus polymethoxy flavonoid, suppresses gene expression and production of aggrecanases-1 and -2 in collagen-induced arthritic mice by Imada K1, Lin N, Liu C, Lu A, Chen W, Yano M, Sato T, Ito A.(PubMed)