Monday, January 11, 2016

The smoothie of Green Tea, Grape and Pumpkin for Prevention and Treatment of Polymyalgia Rheumatica(PMR) Back by Renowned Institution

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
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Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for people with high risk Polymyalgia Rheumatica and Polymyalgia Rheumatica
Yield: 2 serving (about 8 ounce each)
1 1/4 cups grape
1/4 cup pumpkin
1 cup green tea drink (Make from 4 grams of green tea, and a cup of hot water lipped for 5 minutes. Set aside for cooling to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding the natural ingredients for improvement of Polymyalgia Rheumatica is considered as a dream of many scientist. Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center. Some even produce conflicted results in second and further studies.

Scientist at the some research centers may have found the way to reduce risk and treatment of inflammatory rheumatic disease such as Polymalagia Arthritis. Green tea(1), Grape(1) and pumpkins(1) may be one of the findings with potential and pharmaceutical ingredients.

Polymalagia Arthritis is defined as a condition a common inflammatory rheumatic disease which cause pain, stiffness and tenderness in large muscles, including muscles shoulders and pelvic girdleas a result of the presence of a synovitis in proximal joints and periarticular structures, causing musculoskeletal symptoms in PMR.

Green tea, is a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. Its flavonoids play an important role in expression of antioxidative, anti-inflammatory and anti-neoplastic activities against chronic inflammatory diseases, including PMR through inhibiting the disorders induced by inflammatory pathways(2).
According to the Banaras Hindu University, (-)-epigallocatechin-3-gallate (EGCG), the predominangreen tea polyphenol also inhibits enzyme activities and signal transduction of DNA is transferred from one bacterium to another by a virus pathways related to the inflammation and joint destruction in arthritis(3).

Resveratrol (RES), is a well-known antioxidant and anti-inflammatory compound found abundantly in grapes.
Use conjunction with Norisoboldine (NOR), the combination attenuated OC differentiation and bone erosion through the activation of AhR in bone regulation and the subsequent inhibition of NF-κB and proinlammatory pathways(4), according to the China Pharmaceutical University.
Also when use together with curcumin, the combination expressed a remarkable anti-inflammatory activity with inhibition of 37-55% arthritis induction between day 16 and 22(5).
Dr. Wang P and colleagues at the Chengyang People's Hospital of Qingdao City said," Resveratrol has been shown to exert anti-inflammatory and antioxidant effects, while sodium alginate is a common pharmaceutic adjuvant with antioxidative and immunomodulatory properties" in the study of resveratrol on acute gouty arthritis(6).

Pumpkin is the genus Cucurbita and belong the family Cucurbitaceae. The origin of pumpkins is unknown, although many people believe that they have originated in North America. Its phytochemical, cucurbitacins have exhibited the anti inflammatory diseases and may also be used for reduced risk and treatment of Polymyalgia Rheumatica(PMR)(1).
According to the Cairo University, Cairo University, cucurbitacins found in Iberis amara, extract promotes anti rheumatic inflammatory conditions to help safeguard the integrity of the endothelium and reduces the risk of vascular complications(7).
The University of South of Santa Catarina study also lend a support of anti inflammatory effect of cucurbitacins through suppressing the COX-2 proinflammatory cytokines(8).
In animal model, Dr. Escandell JM and the research team at the Universitat de València said," experimental data on the chronic model, together with previously reported activity on acute and subchronic experimental models, justify the anti-inflammatory activity of cucurbitacin R and provide further evidence for the therapeutic potential of a group of natural products as anti-inflammatory agents"(9).

People who are at increased risk of Polymyalgia Rheumatica(PMR) due to aging, occupations, family history, gene mutation,....should drink at least one cup daily and people with Polymyalgia Rheumatica(PMR) should drink the smoothie as much as they can, depending to digestive and liver toleration.
Change of life style and diet pattern are also recommended.

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By addressing the Underlying Causes through Clinical Trials and Studies

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(1) Anti-inflammatory agents from plants: progress and potential by Recio MC1, Andujar I, Rios JL.(PubMed)
(2) [Anti-inflammatory effects of tea-flavonoids].[Article in German] by Hoensch H1, Oertel R.(PubMed)
(3) Green tea polyphenol epigallocatechin-3-gallate: inflammation and arthritis. [corrected]. by Singh R1, Akhtar N, Haqqi TM.(PubMed)
(4) Norisoboldine, an Anti-Arthritis Alkaloid Isolated from Radix Linderae, Attenuates Osteoclast Differentiation andInflammatory Bone Erosion in an Aryl Hydrocarbon Receptor-Dependent Manner by Wei ZF1, Lv Q1, Xia Y1, Yue MF1, Shi C1, Xia YF1, Chou GX2, Wang ZT2, Dai Y1.(PubMed)
(5) A novel approach to arthritis treatment based on resveratrol and curcumin co-encapsulated in lipid-core nanocapsules: In vivo studies by Coradini K1, Friedrich RB1, Fonseca FN1, Vencato MS2, Andrade DF1, Oliveira CM3, Battistel AP3, Guterres SS1, da Rocha MI2, Pohlmann AR4, Beck RC5.(PubMed)
(6) Effect of sodium alginate addition to resveratrol on acute gouty arthritis by Wang P1, Ren D, Chen Y, Jiang M, Wang R, Wang YG.(PubMed)
(7) Mechanisms Involved in the Anti-inflammatory and Vascular Effects of Iberis amara Extract by Khayyal MT1, Agha AM1, Zaki HF1, El-Sahar A1, Abdel-Aziz H2.(PubMed)
(8) Nitric oxide and cyclooxygenase may participate in the analgesic and anti-inflammatory effect of the cucurbitacins fraction from Wilbrandia ebracteata by Peters RR1, Baier Krepsky P, Siqueira-Junior J, da Silva Rocha JC, Marques Bezerra M, de Albuquerque Ribeiro R, de Brum-Fernandes AJ, Rocha Farias M,Castro da Rocha FA, Ribeiro-do-Valle RM.(PubMed)
(9) Cucurbitacin R reduces the inflammation and bone damage associated with adjuvant arthritis in lewis rats by suppression of tumor necrosis factor-alpha in T lymphocytes and macrophages. by Escandell JM1, Recio MC, Máñez S, Giner RM, Cerdá-Nicolás M, Ríos JL.(PubMed)

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