Sunday, January 10, 2016

The curable Smoothie of Green Tea, Grape and Orange for Reduced Risk and Treatment of Rheumatoid Arthritis(RA) back by Clinical Trials and Studies of Respectable Institutions

Kyle J. Norton(Scholar, master of nutrients), all right reserved
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for people with Rheumatoid Arthritis and high risk of the disease

Yield: 2 serving (about 8 ounce each)
3/4  cup grape
3/4 cup orange
1 cup green tea drink (Make from 4 grams of green tea, and a cup of hot water lipped for 5 minutes. Set aside for cooling to room temperature)

1. Place tall ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for reduced risk and treatment of Rheumatoid Arthritis has encountered many obstacles, many ingredients showed initially the promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.

Rheumatoid Arthritis is defined a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body. The disease affects more women than men and generally occurs after the ages of 40, causing the diminished quality of life of many elders.

Green Tea Epigallocatechin-3-Gallate(1)Grape(5) and Orange(10), may be next generation of pharmaceutical ingredients for reduced risk and treatment of Rheumatoid Arthritis due to their effects in suppressing autoimmunity. According to the joint studu lead by the University of Texas Southwestern Medical Center, the polyphenol (-)-epigallocatechin-3-gallate (EGCG), EGCG significantly suppressed T cell proliferation and relative frequencies of CD4 T cells, CD8 T cells and B cell subsets through mediated the immunoregulation(1).
In rats with adjuvant-induced arthritis, green tea treatment effectively normalized the activity of glucose 6-phosphate dehydrogenase, a key enzyme of an important metabolic route (pentose monophosphate pathway) that are substantially modified by arthritis(2).
Dr. Ramadan G and colleagues in the expression of green tea used for treatment against inflammatory diseases including Rheumatoid Arthritis suggested that the potent of green tea in reduced inflammtory expression may be due to its inhibition of proinflammatory activities(3).
Furthermore, green tea extract (GTE) aslo was found effectively in regulating chemokine production and chemokine receptor expression in human RA synovial fibroblasts and rat adjuvant-induced arthritis (AIA), through expression of anti inflammatory cytokines pathways(4).

Intake of grape with abundant quercetin, resveratrol and procyanidins may be able to modulate chronic inflammatory diseases including rheumatoid arthritis, inflammatory bowel disease,....(5). 
Resveratrol is best known to consist significant anti-inflammatory effects on AA rats, which may be associated with the reduction of COX-2 and PGE2 inflammatory mediators(8)..
According to the Hyogo College of Medicine, resveratrol induces apoptosis MH7A human rheumatoid arthritis synovial cells by activating caspase-9( in apoptosis and cytokine processing) and the effector caspase-3(responsible for apoptosis execution) along mitochondrial disruption(6).
Vam3, a derivative of resveratrol was found to interact with spleen tyrosine kinase (SYK) which plays a crucial role in adaptive immune receptor signalling, according to the joint study lead by the Peking Union Medical College, in extracellular antigen-induced crosslinking of type of antibody in the pathogenesis of autoimmune disorders, such as rheumatoid arthritis(7).

Orange is a species of Citrus Sinensis, belong to the family Rutaceae and native to the Southeast Asia. Orange is round citrus fruits with finely-textured skins, orange in color and one of most popular fruits in the world. Chronic intake of citrus fruits is found to associate to lower RA risk(10)
According to the Iwaki Meisei University, Orange flavanone naringin showed effectively in inhibit the inflammatory responses in mice with collagen-induced arthritis (CIA), a mouse model for RA(9).
In collagen-induced arthritic mice, nobiletin found abundantly in orange and other citrus fruits effectively interferes with gene expression of ADAMTS-4 and -5(inflammatory regulated enzymes ), and thereby prevents cartilage destruction in CIA mice(11).

Taking altogether, people who are at increased of Rheumatoid Arthritis(RA) due to family history, gene mutation,....should drink at least one cup daily and people with Rheumatoid Arthritis(RA) should drink the smoothie as much as they can, depending to digestive and liver toleration.
Change life style and diet pattern are also recommended.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

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(1) Green Tea Epigallocatechin-3-Gallate Suppresses Autoimmune Arthritis Through Indoleamine-2,3-Dioxygenase Expressing Dendritic Cells and the Nuclear Factor, Erythroid 2-Like 2 Antioxidant Pathway by Min SY1, Yan M1, Kim SB2, Ravikumar S3, Kwon SR4, Vanarsa K3, Kim HY5, Davis LS1, Mohan C3.(PubMed)
(2) Green tea extract improves the oxidative state of the liver and brain in rats with adjuvant-induced arthritis by de Almeida Gonçalves G1, de Sá-Nakanishi AB, Wendt MM, Comar JF, Bersani Amado CA, Bracht A, Peralta RM.(PubMed)
(3) Anti-inflammatory activity of green versus black tea aqueous extract in a rat model of human rheumatoid arthritis by Ramadan G1, El-Beih NM1, Talaat RM2, Abd El-Ghffar EA1.(PubMed)
(4) Green tea extract inhibits chemokine production, but up-regulates chemokine receptor expression, in rheumatoid arthritis synovial fibroblasts and rat adjuvant-induced arthritis by Marotte H1, Ruth JH, Campbell PL, Koch AE, Ahmed S.(PubMed)
(5) Effects of antioxidant polyphenols on TNF-alpha-related diseases by Kawaguchi K1, Matsumoto T, Kumazawa Y.(PubMed)
(6) Resveratrol induces apoptosis MH7A human rheumatoid arthritis synovial cells in a sirtuin 1-dependent manner by Nakayama H1, Yaguchi T, Yoshiya S, Nishizaki T.(PubMed)
(7) A combined experimental and computational study of Vam3, a derivative of resveratrol, and Syk interaction by Jiang M1, Liu R2, Chen Y3, Zheng Q4, Fan S5, Liu P6.(PubMed)
(8) Anti-inflammatory effect of resveratrol on adjuvant arthritis rats with abnormal immunological function via the reduction of cyclooxygenase-2 and prostaglandin E2 by Chen X1, Lu J1, An M1, Ma Z1, Zong H1, Yang J1.(PubMed)
(9) Suppression of inflammatory responses after onset of collagen-induced arthritis in mice by oral administration of the Citrus flavanone naringin by Kawaguchi K1, Maruyama H, Hasunuma R, Kumazawa Y.(PubMed)
(10) Effects of antioxidant polyphenols on TNF-alpha-related diseases by Kawaguchi K1, Matsumoto T, Kumazawa Y.(PubMed)
(11) Nobiletin, a citrus polymethoxy flavonoid, suppresses gene expression and production of aggrecanases-1 and -2 in collagen-induced arthritic mice by Imada K1, Lin N, Liu C, Lu A, Chen W, Yano M, Sato T, Ito A.(PubMed)

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