By Kyle J. Norton Health article writer and researcher; Over
10.000 articles and research papers have been written and published on
line, including world wide health, ezine articles, article base,
healthblogs, selfgrowth, best before it's news, the karate GB daily,
etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by
Disilgold.com Named 50 of the best health Tweeters Canada - Huffington
Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as
international journal Pharma and Bio science, ISSN 0975-6299.
Diseases of Central Nervous system
Dementia
About 5-8% of all people over the age of 65 have some form of dementia,
and this number doubles every five years above that age. Dementia is
the loss of mental ability, severe enough to interfere with people's
every life and Alzheimer's disease is the most common type of dementia
in aging people.
V. Preventions
C. Phytochemicals Against Dementia
C.4. Tangeritin
Tangeritin, one of the flavones, is found in tangerine and many citrus peels.
1. Neuroprotective effects
Natural antioxidant tangeretin,
may be used as neuroprotective agent, for its significant effects on
protection of striato-nigral integrity and functionality in patients
with Parkinson's disease(327), probably through its anti-neuroinflammatory activity(328) via mitochondrial depolarization(329) in attenuated reactive oxygen species generation.
2. Antioxidants
Mature and immature calamondin (Citrus mitis Blanco) peel, containing tangeretin showed to exhibit its antioxidant(331) in enhancing
the highest oxygen radical absorbance capacity (ORAC) reducing power,
and superoxide scavenging effect(330), as well as ameliorating oxidative
stress causes of DNA damage(332), mammary carcinoma(333)(334) and
diabetes(335).
C.5. Curcumin
Turmeric, principal curcuminoid of the popular Indian spice, is a rhizomatous herbaceous perennial plant of the ginger family, Zingiberaceae, native to tropical
South Asia, used in traditional herbal medicine
as an anti-inflammatory agent and to treat gastrointestinal symptoms
associated with irritable bowel syndrome and other digestive disorders(336). Curcumin, a phytochemical
found abundant in the plant, in acidic solutions (pH <7.4) turns
yellow, whereas in basic (pH > 8.6) solutions turns bright red.
1. Alzheimer's disease and Anti-inflammatory agent
a. Alzheimer's disease
Increased antioxidant and
anti-inflammatory consumption such as curcumin may reduce risk of Alzheimer's disease
(AD) caused by amyloid beta (Abeta) accumulation(338) through
reversal of Abeta-induced cognitive deficits and neuropathology(339).
The phytochemical is also found to disaggregate Abeta in preventing
fibril and
oligomer formation(338). According to Yamagata University, its synthesized curcumin analogues used pharmateutically in treatment of amyloid β aggregation also experience notable result(337). In vitro and animal models, curcumin
was effective, in lowering oxidative damage, cognitive deficits, synaptic
marker loss, and amyloid depositio in prevented onset of Alzheimer's disease(340).
b. Anti-inflammatory agent
Curcumin,
an anti-inflammatory agent(341), in the pathogenesis of psoriasis and
neurodegenerative diseases,, decreased the expression of
pro-inflammatory cells signalling in response to inflammation(342)(343),
in patients of ear infection and Parkinson's disease and Alzheimer's disease(344)(345), respectively.
2. Antioxidants
Curcumin
also consisting anti-proliferative, anti-inflammatory and immunosuppressive
activitie(346), in arthritis, strongly inhibited collagenase and
stromely in expression at micromolar concentrations(346); in diabetes,
scavenged free radicals and reduced LDL oxidation and cellular oxidative
stress(347); in cancers, reduced accumulation of ROS causes of abnormal
cells(348), through apoptosis(349); in neurodegenerative diseases,
exerted autophagy-lysosomal activities, through removing damaged or
dysfunctional proteins and cells with specific function(350) and
regulating reactive oxygen species (ROS)(351)(352).
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References
(327) http://www.ncbi.nlm.nih.gov/pubmed/11726811
(328) http://www.ncbi.nlm.nih.gov/pubmed/24462494
(329) http://www.ncbi.nlm.nih.gov/pubmed/22678994
(330) http://www.ncbi.nlm.nih.gov/pubmed/23194504
(331) http://www.ncbi.nlm.nih.gov/pubmed/20420369
(332) http://www.ncbi.nlm.nih.gov/pubmed/24995432
(333) http://www.ncbi.nlm.nih.gov/pubmed/24299963
(334) http://www.ncbi.nlm.nih.gov/pubmed/25151216
(335) http://www.ncbi.nlm.nih.gov/pubmed/24629597
(336) http://www.sciencedirect.com/science/article/pii/S0308814608009084
(337) http://www.ncbi.nlm.nih.gov/pubmed/2546714
(338) http://www.ncbi.nlm.nih.gov/pubmed/15590663
(339) http://www.ncbi.nlm.nih.gov/pubmed/11755008
(340) http://www.ncbi.nlm.nih.gov/pubmed/25467149
(341) http://www.ncbi.nlm.nih.gov/pubmed/3546166
(342) http://www.ncbi.nlm.nih.gov/pubmed/23825622
(343) http://www.ncbi.nlm.nih.gov/pubmed/25514226
(344) http://www.ncbi.nlm.nih.gov/pubmed/20930270
(345) http://www.ncbi.nlm.nih.gov/pubmed/22426019
(346) http://www.ncbi.nlm.nih.gov/pubmed/16807698
(347) http://www.ncbi.nlm.nih.gov/pubmed/25477660
(348) http://www.ncbi.nlm.nih.gov/pubmed/15700780
(349) http://www.ncbi.nlm.nih.gov/pubmed/25349781
(350) http://www.ncbi.nlm.nih.gov/pubmed/24494187
(351) http://www.ncbi.nlm.nih.gov/pubmed/24335167
(352) http://www.ncbi.nlm.nih.gov/pubmed/24008671
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