Most common diseases of 50 plus - Diseases of Central Nervous system - Hormonal Causes of Dementia

By Kyle J. Norton 
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               Diseases of Central Nervous system

                                 Dementia

About 5-8% of all people over the age of 65 have some form of dementia, and this number doubles every five years above that age. Dementia is the loss of mental ability, severe enough to interfere with people's every life and Alzheimer's disease is the most common type of dementia in aging people.
 II. Causes of dementia 
 E. Hormonal Causes of  Dementia
1. Growth hormone
According to Universidad de Barcelona, Barcelona, physiological decline of the growth hormone (GH)/insulin-like growth factor-I (IGF-I) axis due to ageing, may involve in the progression of  cognitive deficits(116), probably due to ability of both hormones in stimulation of beta amyloid release from neurons and IGF-I involved on brain amyloid clearance(117).

2.  Estrogen
According to Scientist at the Kings College London, the decreased production of estrogen due to aging in menopausal women may be association to the risk of dementia(118). Estrogen-replacement therapy has shown to reduce prevalence of Alzheimer's disease in postmenopausal women, but weighing risks and benefits of estrogen-replacement therapy must be taken into account(119)

3. Testosterone 
Lower androgen levels in aging are associated with increased plasma Abeta 40 in older men with memory loss or dementia, according to the comparison of levels of  serum total testosterone and sex hormone binding globulin (SHBG) and plasma levels of amyloid beta peptide 40(120).

4. DHEA
According to studies, a decreased concentration of dehydroepiandrosterone sulfate (DHEA-S) and lower DHEA-S/DHEA ratio are associated to risk of Alzheimer's disease (AD)(121)(122).

5. Sex-hormone binding globulin 
 Gonadotropins may be involved in processes and contribution to the etiology/pathogenesis of AD due to its involvement on inflammation, cholesterol homeostasis, and insulin status(123).

6. Etc.
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References
(116) http://www.ncbi.nlm.nih.gov/pubmed/18537700
(117) http://www.ncbi.nlm.nih.gov/pubmed/15094079
(118) http://www.ncbi.nlm.nih.gov/pubmed/20840280
(119) http://www.ncbi.nlm.nih.gov/pubmed/9566385
(120) http://www.ncbi.nlm.nih.gov/pubmed/14624021
(121) http://www.ncbi.nlm.nih.gov/pubmed/8732462
(122) http://www.ncbi.nlm.nih.gov/pubmed/19665809
(123) http://www.ncbi.nlm.nih.gov/pubmed/16785601