Green tea, in Reduced Risk and Treatment of Alzheimer's disease

Alzheimer's disease is a neurodegenerative condition of loss or decrease of cognitive and memory functions due to aging.

According to the Maternal and Infant Health, ASL NA 3 SUD, epigallocatechin, and gallic acid, (-)-Epigallocatechin-3-Gallate (EGCG), found in green tea exerted a strong anti-inflammatory and anti oxidative properties in protection against neuronal damage and brain edema.

The study also stated that green tea may also contribute to reduced risk and treatment of AD by ameliorated chronic viral infection, one of the cause in responsible for AD's neuropathology.


Dr. Mandel SA. the lead author and expert in green tea study said, "tea drinking may decrease the incidence of dementia, AD, and PD. In particular, its main catechin polyphenol constituent (-)-epigallocatechin-3-gallate (EGCG) has been shown to exert neuroprotective/neurorescue activities in a wide array of cellular and animal models of neurological disorders".

Other researchers suggested that the efficacy of epigallocatechin and gallic acid, (-)-Epigallocatechin-3-Gallate (EGCG) in reduced risk of AD may be attributed to
1. The antioxidant activity in ameliorating production of ROS in the induced risk of oxidative stress which has been found to associate to the production of lipid peroxidation, leading to abnormal deposition of amyloid β (Aβ) peptide

2. Free radical overexpression in aging people also vulnerable to an imbalance of antioxidant and ROS
may have negatively direct interaction with proteins, nucleic acids, and other molecules and may also alter their structures and functions in inducing risk AD.


Indeed, as a single ingredient isolated from green tea, epigallocatechin and gallic acid, (-)-Epigallocatechin-3-Gallate (EGCG) have been found to cause toxicity in some cases in the medical literature. Therefore taking the ingredient in long term and overdoses may have an implication of liver damage.


In an animal study to evaluate the efficacy of Caffeic acid in AD, mice rats randomly divided into three groups: i) control group, ii) AD model group and iii) caffeic acid group, mice fed with the phytochemical expressed a significant in increased learning deficit and cognitive function demonstrated by the Morris water maze task in compared control.

Additionally, fed mice also displayed attenuated oxidative stress, inflammation, nuclear factor‑κB‑p65 protein expression involved inflammatory cytokines production and suppressed caspase‑3 activity-induced cell death and other mechanisms in the rats with AD.

Interestingly, the inflammatory process has shown to have a negative role in an increased risk of AD, by causing neuroinflammation, including brain cells such as microglia and astrocytes and subsequently in promoted dysfunction and neuronal death. Therefore by suppressing the production of inflammatory cytokines, caffeic acid expressed a significant reduction of AD risk.


The efficacy in the contribution of cognitive improvement following caffeic acid application may be due to its antioxidant activity and restoration of cholinergic functions, as deficiency of cholinergic function has shown to affect cognition, behavior, and activities of daily living

Taking all together, there is no doubt that green process a neuroprotective against the risk and progression of patients with Alzheimer's disease (AD) attributed to some of the major chemical constituents. But the intake of a single ingredient isolated from green tea should be taken with care.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

Sources
(1) The efficacy of Epigallocatechin-3-gallate (green tea) in the treatment of Alzheimer's disease: an overview of pre-clinical studies and translational perspectives in clinical practice by Cascella M#1, Bimonte S#1, Muzio MR2, Schiavone V3, Cuomo A1.(PubMed)
(2) Simultaneous manipulation of multiple brain targets by green tea catechins: a potential neuroprotective strategy for Alzheimer and Parkinson diseases by Mandel SA1, Amit T, Weinreb O, Reznichenko L, Youdim MB.(PubMed)
(3) Effects of caffeic acid on learning deficits in a model of Alzheimer's disease by Wang Y1, Wang Y2, Li J1, Hua L3, Han B1, Zhang Y1, Yang X3, Zeng Z3, Bai H3, Yin H1, Lou J3.(PubMed)
(4) Caffeic acid attenuates oxidative stress, learning and memory deficit in intra-cerebroventricular streptozotocin induced experimental dementia in rats by Deshmukh R1, Kaundal M2, Bansal V2, Samardeep2(PubMed).