Most Common Diseases of elder: Respiratory Disease: Asthma Treatment: The Important Vitamin K

Kyle J. Norton(Scholar and Master of Nutrients)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Respiratory Disease is defined as medical conditions which affect the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.

                                  Asthma

Asthma is a chronic inflammatory disease affecting the air way of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages, and mostly starts during childhood. In the study of 463,801 children aged 13-14 years in 155 collaborating centres in 56 countries. Children self-reported, through one-page questionnaires, symptoms of these three atopic disorders. In 99 centres in 42 countries, a video asthma questionnaire was also used for 304,796 children, found that for asthma symptoms, the highest 12-month prevalences were from centres in the UK, Australia, New Zealand, and Republic of Ireland, followed by most centres in North, Central, and South America; the lowest prevalences were from centres in several Eastern European countries, Indonesia, Greece, China, Taiwan, Uzbekistan, India, and Ethiopia(1). In the United States, approximately, asthma affects 25 million people, 7 million of them are children.

                   The Effectiveness of Vitamin K

Vitamin K(K1, phylloquinone; K2, menaquinones), is a fat soluble vitamin, found abundantly in leafy green vegetables, broccoli, and Brussels sprouts, etc. It is best known for promotion of coagulation and bone health.
Epidemiological studies focusing vitamin K in reduced risk and treatment of asthma have been inconclusive(a)(b)(c).

Menaquinone (vitamin K2), a variant of vitamin K, in a double blind study of 191 patients with bronchial asthma, showed an effective rate of 90.9% in mild patients, 86.7% in moderate patients, and 72.7% in severe patients(1). Other researchers suggested that treatment of menaquinone for long periods in patients with bronchial asthma indicated a significant inhibition of the disease(2). The data base of PubMed showed limitation in quantity of the research, we, therefore make no conclusion of the effectiveness of the vitamin in reduced risk and treatment of asthma. Overdoses can induce symptoms of Skin rash, Diarrhea, Nausea, Vomiting, Anemia, etc. Please make sure you follow the guideline of the Institute of Medicine of the National Academies.


All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offerrecommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(a) Maternal intake of vitamins A, E and K in pregnancy and child allergic disease: a longitudinal study from the Danish National Birth Cohort by Maslova E, Hansen S, Strøm M, Halldorsson TI, Olsen SF.(PubMed)
(b) Fat-soluble vitamins and atopic disease: what is the evidence? by Litonjua AA.(PubMed)
(c) [Antioxidant and fat intake in patients with polinic asthma].[Article in Spanish] by de Luis DA1, Izaola O, Aller R, Armentia A, Cuéllar L.(PubMed)
(1) Menaquinone (vitamin K2) therapy for bronchial asthma. II. Clinical effect of menaquinone on bronchial asthma by Kimur I, Tanizaki Y, Sato S, Saito K, Takahashi K.(PubMed)
(2) Menaquinone (vitamin K2) therapy for bronchial asthma. I. Mechanism of action menaquinone on allergic reactions by Kimura I, Tanizaki Y, Sato S, Saito K, Takahashi K.(PubMed)

The smoothie of Green Tea, Grape and Pumpkin for Prevention and Treatment of Polymyalgia Rheumatica(PMR) Back by Renowned Institution

Kyle J. Norton(Scholar, Master of Nutrients), all right reserved.
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.


The smoothie for people with high risk Polymyalgia Rheumatica and Polymyalgia Rheumatica
Yield: 2 serving (about 8 ounce each)
1 1/4 cups grape

1/4 cup pumpkin
1 cup green tea drink (Make from 4 grams of green tea, and a cup of hot water lipped for 5 minutes. Set aside for cooling to room temperature)

1. Place all ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed. Add more green tea drink if needed
3. Serve immediately

The finding the natural ingredients for improvement of Polymyalgia Rheumatica is considered as a dream of many scientist. Unfortunately, many compounds found effective in initial studying failed to confirm the potential in large sample size and multi center. Some even produce conflicted results in second and further studies.

Scientist at the some research centers may have found the way to reduce risk and treatment of inflammatory rheumatic disease such as Polymalagia Arthritis. Green tea(1), Grape(1) and pumpkins(1) may be one of the findings with potential and pharmaceutical ingredients.

Polymalagia Arthritis is defined as a condition a common inflammatory rheumatic disease which cause pain, stiffness and tenderness in large muscles, including muscles shoulders and pelvic girdleas a result of the presence of a synovitis in proximal joints and periarticular structures, causing musculoskeletal symptoms in PMR.

Green tea, is a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Due to its commercial values and health effects, green tea now has been cultivated all over the world in suitable climate. Its flavonoids play an important role in expression of antioxidative, anti-inflammatory and anti-neoplastic activities against chronic inflammatory diseases, including PMR through inhibiting the disorders induced by inflammatory pathways(2).

According to the Banaras Hindu University, (-)-epigallocatechin-3-gallate (EGCG), the predominant green tea polyphenol also inhibits enzyme activities and signal transduction of DNA is transferred from one bacterium to another by a virus pathways related to the inflammation and joint destruction in arthritis(3).

Resveratrol (RES), is a well-known antioxidant and anti-inflammatory compound found abundantly in grapes.

Use conjunction with Norisoboldine (NOR), the combination attenuated OC differentiation and bone erosion through the activation of AhR in bone regulation and the subsequent inhibition of NF-κB and proinlammatory pathways(4), according to the China Pharmaceutical University.

Also when use together with curcumin, the combination expressed a remarkable anti-inflammatory activity with inhibition of 37-55% arthritis induction between day 16 and 22(5).
Dr. Wang P and colleagues at the Chengyang People's Hospital of Qingdao City said," Resveratrol has been shown to exert anti-inflammatory and antioxidant effects, while sodium alginate is a common pharmaceutic adjuvant with antioxidative and immunomodulatory properties" in the study of resveratrol on acute gouty arthritis(6).

Pumpkin is the genus Cucurbita and belong the family Cucurbitaceae. The origin of pumpkins is unknown, although many people believe that they have originated in North America. Its phytochemical, cucurbitacins have exhibited the anti inflammatory diseases and may also be used for reduced risk and treatment of Polymyalgia Rheumatica(PMR)(1).

According to the Cairo University, Cairo University, cucurbitacins found in Iberis amara, extract promotes anti rheumatic inflammatory conditions to help safeguard the integrity of the endothelium and reduces the risk of vascular complications(7).

The University of South of Santa Catarina study also lend a support of anti inflammatory effect of cucurbitacins through suppressing the COX-2 proinflammatory cytokines(8).

In animal model, Dr. Escandell JM and the research team at the Universitat de València said," experimental data on the chronic model, together with previously reported activity on acute and subchronic experimental models, justify the anti-inflammatory activity of cucurbitacin R and provide further evidence for the therapeutic potential of a group of natural products as anti-inflammatory agents"(9).

People who are at increased risk of Polymyalgia Rheumatica(PMR) due to aging, occupations, family history, gene mutation,....should drink at least one cup daily and people with Polymyalgia Rheumatica(PMR) should drink the smoothie as much as they can, depending to digestive and liver toleration.

Change of life style and diet pattern are also recommended.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Super foods Library, Eat Yourself Healthy With The Best of the Best Nature Has to Offerrecommended by Kyle J. Norton

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References

(1) Anti-inflammatory agents from plants: progress and potential by Recio MC1, Andujar I, Rios JL.(PubMed)

(2) [Anti-inflammatory effects of tea-flavonoids].[Article in German] by Hoensch H1, Oertel R.(PubMed)

(3) Green tea polyphenol epigallocatechin-3-gallate: inflammation and arthritis. [corrected]. by Singh R1, Akhtar N, Haqqi TM.(PubMed)

(4) Norisoboldine, an Anti-Arthritis Alkaloid Isolated from Radix Linderae, Attenuates Osteoclast Differentiation andInflammatory Bone Erosion in an Aryl Hydrocarbon Receptor-Dependent Manner by Wei ZF1, Lv Q1, Xia Y1, Yue MF1, Shi C1, Xia YF1, Chou GX2, Wang ZT2, Dai Y1.(PubMed)

(5) A novel approach to arthritis treatment based on resveratrol and curcumin co-encapsulated in lipid-core nanocapsules: In vivo studies by Coradini K1, Friedrich RB1, Fonseca FN1, Vencato MS2, Andrade DF1, Oliveira CM3, Battistel AP3, Guterres SS1, da Rocha MI2, Pohlmann AR4, Beck RC5.(PubMed)

(6) Effect of sodium alginate addition to resveratrol on acute gouty arthritis by Wang P1, Ren D, Chen Y, Jiang M, Wang R, Wang YG.(PubMed)

(7) Mechanisms Involved in the Anti-inflammatory and Vascular Effects of Iberis amara Extract by Khayyal MT1, Agha AM1, Zaki HF1, El-Sahar A1, Abdel-Aziz H2.(PubMed)

(8) Nitric oxide and cyclooxygenase may participate in the analgesic and anti-inflammatory effect of the cucurbitacins fraction from Wilbrandia ebracteata by Peters RR1, Baier Krepsky P, Siqueira-Junior J, da Silva Rocha JC, Marques Bezerra M, de Albuquerque Ribeiro R, de Brum-Fernandes AJ, Rocha Farias M,Castro da Rocha FA, Ribeiro-do-Valle RM.(PubMed)

(9) Cucurbitacin R reduces the inflammation and bone damage associated with adjuvant arthritis in lewis rats by suppression of tumor necrosis factor-alpha in T lymphocytes and macrophages. by Escandell JM1, Recio MC, Máñez S, Giner RM, Cerdá-Nicolás M, Ríos JL.(PubMed)

Most Common Diseases of elder: Respiratory Disease: Asthma Treatment: The Effectiveness of Vitamin D

Kyle J. Norton(Scholar and Master of Nutrients)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Respiratory Disease is defined as medical conditions which affect the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.

                                  Asthma

Asthma is a chronic inflammatory disease affecting the air way of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages, and mostly starts during childhood. In the study of 463,801 children aged 13-14 years in 155 collaborating centres in 56 countries. Children self-reported, through one-page questionnaires, symptoms of these three atopic disorders. In 99 centres in 42 countries, a video asthma questionnaire was also used for 304,796 children, found that for asthma symptoms, the highest 12-month prevalences were from centres in the UK, Australia, New Zealand, and Republic of Ireland, followed by most centres in North, Central, and South America; the lowest prevalences were from centres in several Eastern European countries, Indonesia, Greece, China, Taiwan, Uzbekistan, India, and Ethiopia(1). In the United States, approximately, asthma affects 25 million people, 7 million of them are children.

                   The Effectiveness of Vitamin D

Vitamin D is a fat-soluble secosteroids found in small amount in few foods, including salmon, mackerel, sardines and tuna. The vitamin plays an important role in modulation of cellular proliferation, apoptosis induction, tumor growth suppression and promotion in absorption of minerals, including calcium, iron, magnesium, phosphate and zinc.

1. Serum of vitamin D
Epidemiological studies, linking the levels of serum 25-OH vitamin D withasthma may be inconclusive. The study of included 4,999 adults aged 30-60 years in 1999-2001. 3,032 of those included at baseline also participated at a follow-up examination 5 years later and 3,727 answered a 10 year follow-up questionnaire, showed no association of serum serum 25-OH vitamin D and the risk of asthma in Danish adults(1)(1a). Some researchers in the study of general Korean population suggested that vitamin D-insufficiency may have an increased likelihood of atopic dermatitis, but not asthma, allergic rhinitis, or IgE sensitization(2)(2a). But the study by Royal Brompton Hospital, London indicated otherwise of relationships between serum vitamin D, lung function, and pathology in children with severe, therapy-resistant asthma(STRA)(3)(4) and 25 hydroxy vitamin D insufficiency wass associated with bronchial asthma(4a) On the other hand, the study of iMayo Clinic indicated the correlation between serum 25(OH)D concentrations and positive pneumococcal antibody levels in all subjects regardless of asthma(5).

2. The benefits
According to the study by Universitätsmedizin Berlin, oral administration of vitamin D in vitamin D deficiency induced asthma, showed an increased expression of CD38 on B cells and a decreased T-cell-dependent proinflammatory cytokine production(6). In support to above study, Vitamin D found to decreased inflammatory cytokine production from T-cell subsets implicated in asthma, according to Florida Atlantic University(7). In patient with steroid-resistant (SR) and steroid-sensitive (SS) asthma, oral administration of vitamin D, although exerted its anti-inflammatory and corticosteroid-enhancing effects in monocytes of patients with SR asthmaand patients with SS asthma, the responses to corticosteroids in patients with SR asthma remained significantly lower than those in patients with SSasthma(8). Other in the study of the effect of vitamin D in severe therapy-resistant asthma (STRA) patients, showed an positive effect of 1α,25-dihydroxyvitamin D3, the active form of vitamin D in culture enhanced dexamethasone-induced IL-10 (Defective IL-10 expression causes a significantly diminished levels of anti-inflammatory interleukin (IL)-10))without marked effects on IL-13 or IL-17A production(9). Patients with severe asthmaexhibited increased levels of TH17 cytokines.The study of King's College London, also suggested that 1,25(OH)2D3 inhibits TH17 cytokine production in all patients with moderate-to-severe asthma(10), enhances the frequency of Treg cells(11)and upregulates CD200 on peripheral human CD4+ T cells(12).

Taken altogether, without going into reviews, vitamin D used conjunction with other anti asthma medicine and its the active form 1α,25-dihydroxyvitamin D3, may be associated to reduced risk and treatment of asthmatic diseases. Over doses of vitamin D supplement may cause excessive calcium absorption, calcification, Urinary stones etc. please make sure to follow the guideline of the Institute of Medicine of the National Academies.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(1) The association of serum 25-OH vitamin D with atopy, asthma, and lung function in a prospective study of Danish adults by Thuesen BH1, Skaaby T, Husemoen LL, Fenger M, Jørgensen T, Linneberg A.(PubMed)
(1a) Vitamin d in pediatric inpatients with respiratory illnesses by Iqbal S1, Mosenkis EV, Jain P, Wiles A, Lerner J, Benton AS, Chamberlain JM, Freishtat RJ, Teach SJ.(PubMed)
(2) Low vitamin D levels are associated with atopic dermatitis, but not allergic rhinitis, asthma, or IgE sensitization, in the adult Korean population by Cheng HM1, Kim S2, Park GH3, Chang SE4, Bang S5, Won CH4, Lee MW4, Choi JH4, Moon KC(PubMed)
(2a) Vitamin D with asthma and COPD: not a false hope? A systematic review and meta-analysis By Zhang LL1, Gong J2, Liu CT3.(PubMed)
(3) Childhood asthma and vitamin D deficiency in Turkey: is there cause and effect relationship between them? Uysalol M1, Mutlu LC, Saracoglu GV, Karasu E, Guzel S, Kayaoglu S, Uzel N.(PubMed)
(4) Relationship between serum vitamin D, disease severity, and airway remodeling in children with asthma by Gupta A1, Sjoukes A, Richards D, Banya W, Hawrylowicz C, Bush A, Saglani S.(PubMed)
(4a) Serum 25 Hydroxy Vitamin D Insufficiency Associated with BronchialAsthma in Lucknow, India by Awasthi S1, Vikram K.(PubMed)
(5) Serum 25-hydroxyvitamin D is associated with enhanced pneumococcal antibody levels in individuals with asthma by Lee J1, Zhao H, Fenta Y, Kita H, Kumar R, Juhn YJ.(PubMed)
(6) Oral vitamin D increases the frequencies of CD38+ human B cells and ameliorates IL-17-producing T cells by Drozdenko G1, Heine G, Worm M.(PubMed)
(7) Effect of vitamin D on T-helper type 9 polarized human memory cells in chronic persistent asthma by Keating P1, Munim A2, Hartmann JX2.(PubMed)
(8) Anti-inflammatory and corticosteroid-enhancing actions of vitamin D in monocytes of patients with steroid-resistant and those with steroid-sensitiveasthma by Zhang Y1, Leung DY2, Goleva E3.(PubMed)
(9) Defective IL-10 expression and in vitro steroid-induced IL-17A in paediatric severe therapy-resistant asthma by Gupta A1, Dimeloe S, Richards DF, Chambers ES, Black C, Urry Z, Ryanna K, Xystrakis E, Bush A, Saglani S, Hawrylowicz CM.(PubMed)
(10) Enhanced production of IL-17A in patients with severe asthma is inhibited by 1α,25-dihydroxyvitamin D3 in a glucocorticoid-independent fashion by Nanzer AM1, Chambers ES, Ryanna K, Richards DF, Black C, Timms PM, Martineau AR, Griffiths CJ, Corrigan CJ, Hawrylowicz CM.(PubMed)
(11) The role of 1α,25-dihydroxyvitamin D3 and cytokines in the promotion of distinct Foxp3+ and IL-10+ CD4+ T cells by Urry Z1, Chambers ES, Xystrakis E, Dimeloe S, Richards DF, Gabryšová L, Christensen J, Gupta A, Saglani S, Bush A, O'Garra A, Brown Z, Hawrylowicz CM.(PubMed)
(12) 1α,25-dihydroxyvitamin D3 promotes CD200 expression by human peripheral and airway-resident T cells by Dimeloe S1, Richards DF, Urry ZL, Gupta A, Stratigou V, Farooque S, Saglani S, Bush A, Hawrylowicz CM.(PubMed)

Posted by kyle J. Norton at 0

The curable Smoothie of Green Tea, Grape and Orange for Reduced Risk and Treatment of Rheumatoid Arthritis(RA) back by Clinical Trials and Studies of Respectable Institutions

Kyle J. Norton(Scholar, master of nutrients), all right reserved
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for people with Rheumatoid Arthritis and high risk of the disease

Yield: 2 serving (about 8 ounce each)
3/4  cup grape
3/4 cup orange
1 cup green tea drink (Make from 4 grams of green tea, and a cup of hot water lipped for 5 minutes. Set aside for cooling to room temperature)

1. Place tall ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for reduced risk and treatment of Rheumatoid Arthritis has encountered many obstacles, many ingredients showed initially the promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.

Rheumatoid Arthritis is defined a chronic disorder as a result of inflammation, affecting mostly the flexible (synovial) joints and tissues and organs in the body. The disease affects more women than men and generally occurs after the ages of 40, causing the diminished quality of life of many elders.

Green Tea Epigallocatechin-3-Gallate(1)Grape(5) and Orange(10), may be next generation of pharmaceutical ingredients for reduced risk and treatment of Rheumatoid Arthritis due to their effects in suppressing autoimmunity. According to the joint studu lead by the University of Texas Southwestern Medical Center, the polyphenol (-)-epigallocatechin-3-gallate (EGCG), EGCG significantly suppressed T cell proliferation and relative frequencies of CD4 T cells, CD8 T cells and B cell subsets through mediated the immunoregulation(1).

In rats with adjuvant-induced arthritis, green tea treatment effectively normalized the activity of glucose 6-phosphate dehydrogenase, a key enzyme of an important metabolic route (pentose monophosphate pathway) that are substantially modified by arthritis(2).

Dr. Ramadan G and colleagues in the expression of green tea used for treatment against inflammatory diseases including Rheumatoid Arthritis suggested that the potent of green tea in reduced inflammtory expression may be due to its inhibition of proinflammatory activities(3).
Furthermore, green tea extract (GTE) aslo was found effectively in regulating chemokine production and chemokine receptor expression in human RA synovial fibroblasts and rat adjuvant-induced arthritis (AIA), through expression of anti inflammatory cytokines pathways(4).

Intake of grape with abundant quercetin, resveratrol and procyanidins may be able to modulate chronic inflammatory diseases including rheumatoid arthritis, inflammatory bowel disease,....(5). 

Resveratrol is best known to consist significant anti-inflammatory effects on AA rats, which may be associated with the reduction of COX-2 and PGE2 inflammatory mediators(8)..

According to the Hyogo College of Medicine, resveratrol induces apoptosis MH7A human rheumatoid arthritis synovial cells by activating caspase-9( in apoptosis and cytokine processing) and the effector caspase-3(responsible for apoptosis execution) along mitochondrial disruption(6).

Vam3, a derivative of resveratrol was found to interact with spleen tyrosine kinase (SYK) which plays a crucial role in adaptive immune receptor signalling, according to the joint study lead by the Peking Union Medical College, in extracellular antigen-induced crosslinking of type of antibody in the pathogenesis of autoimmune disorders, such as rheumatoid arthritis(7).

Orange is a species of Citrus Sinensis, belong to the family Rutaceae and native to the Southeast Asia. Orange is round citrus fruits with finely-textured skins, orange in color and one of most popular fruits in the world. Chronic intake of citrus fruits is found to associate to lower RA risk(10)

According to the Iwaki Meisei University, Orange flavanone naringin showed effectively in inhibit the inflammatory responses in mice with collagen-induced arthritis (CIA), a mouse model for RA(9).
In collagen-induced arthritic mice, nobiletin found abundantly in orange and other citrus fruits effectively interferes with gene expression of ADAMTS-4 and -5(inflammatory regulated enzymes ), and thereby prevents cartilage destruction in CIA mice(11).

Taking altogether, people who are at increased of Rheumatoid Arthritis(RA) due to family history, gene mutation,....should drink at least one cup daily and people with Rheumatoid Arthritis(RA) should drink the smoothie as much as they can, depending to digestive and liver toleration.

Change life style and diet pattern are also recommended.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References

(1) Green Tea Epigallocatechin-3-Gallate Suppresses Autoimmune Arthritis Through Indoleamine-2,3-Dioxygenase Expressing Dendritic Cells and the Nuclear Factor, Erythroid 2-Like 2 Antioxidant Pathway by Min SY1, Yan M1, Kim SB2, Ravikumar S3, Kwon SR4, Vanarsa K3, Kim HY5, Davis LS1, Mohan C3.(PubMed)

(2) Green tea extract improves the oxidative state of the liver and brain in rats with adjuvant-induced arthritis by de Almeida Gonçalves G1, de Sá-Nakanishi AB, Wendt MM, Comar JF, Bersani Amado CA, Bracht A, Peralta RM.(PubMed)

(3) Anti-inflammatory activity of green versus black tea aqueous extract in a rat model of human rheumatoid arthritis by Ramadan G1, El-Beih NM1, Talaat RM2, Abd El-Ghffar EA1.(PubMed)

(4) Green tea extract inhibits chemokine production, but up-regulates chemokine receptor expression, in rheumatoid arthritis synovial fibroblasts and rat adjuvant-induced arthritis by Marotte H1, Ruth JH, Campbell PL, Koch AE, Ahmed S.(PubMed)

(5) Effects of antioxidant polyphenols on TNF-alpha-related diseases by Kawaguchi K1, Matsumoto T, Kumazawa Y.(PubMed)

(6) Resveratrol induces apoptosis MH7A human rheumatoid arthritis synovial cells in a sirtuin 1-dependent manner by Nakayama H1, Yaguchi T, Yoshiya S, Nishizaki T.(PubMed)

(7) A combined experimental and computational study of Vam3, a derivative of resveratrol, and Syk interaction by Jiang M1, Liu R2, Chen Y3, Zheng Q4, Fan S5, Liu P6.(PubMed)

(8) Anti-inflammatory effect of resveratrol on adjuvant arthritis rats with abnormal immunological function via the reduction of cyclooxygenase-2 and prostaglandin E2 by Chen X1, Lu J1, An M1, Ma Z1, Zong H1, Yang J1.(PubMed)

(9) Suppression of inflammatory responses after onset of collagen-induced arthritis in mice by oral administration of the Citrus flavanone naringin by Kawaguchi K1, Maruyama H, Hasunuma R, Kumazawa Y.(PubMed)

(10) Effects of antioxidant polyphenols on TNF-alpha-related diseases by Kawaguchi K1, Matsumoto T, Kumazawa Y.(PubMed)

(11) Nobiletin, a citrus polymethoxy flavonoid, suppresses gene expression and production of aggrecanases-1 and -2 in collagen-induced arthritic mice by Imada K1, Lin N, Liu C, Lu A, Chen W, Yano M, Sato T, Ito A.(PubMed)

Most Common Diseases of elder: Respiratory Disease: Asthma Treatment: The Effectiveness of Vitamin C

Kyle J. Norton(Scholar and Master of Nutrients, all right reserved)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Respiratory Disease is defined as medical conditions which affect the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.

                                     Asthma

Asthma is a chronic inflammatory disease affecting the air way of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages, and mostly starts during childhood. In the study of 463,801 children aged 13-14 years in 155 collaborating centres in 56 countries. Children self-reported, through one-page questionnaires, symptoms of these three atopic disorders. In 99 centres in 42 countries, a video asthma questionnaire was also used for 304,796 children, found that for asthma symptoms, the highest 12-month prevalences were from centres in the UK, Australia, New Zealand, and Republic of Ireland, followed by most centres in North, Central, and South America; the lowest prevalences were from centres in several Eastern European countries, Indonesia, Greece, China, Taiwan, Uzbekistan, India, and Ethiopia(1). In the United States, approximately, asthma affects 25 million people, 7 million of them are children.

The effective of Vitamin C against Asthma 
Vitamin C, also known as L-ascorbic acid, is a water-soluble vitamin, found in fresh fruits, berries and green vegetables. It is best known for its free radical scavengers activity and regenerating oxidized vitamin E for immune support.
Epidemiological studies, linking vitamin C in reduced risk and treatment of asthma have been inconclusive(a)(b)(c)(d).

The study of the effects of antioxidant nutritional status with allergic rhinitis (AR) in Korean schoolchildren aged 6-12 years, in a total of 4,554 children in Seoul, Korea, showed a positive effect of Vitamin C intake negatively associated with an increased risk of AR symptoms(1). According to the Rabin Medical Center, vitamin C also enhanced the protective effect on the hyperreactive airways of patients with exercise-induced asthma (EIA)(2). Oxidative stress mediated by reactive oxygen species is known to contribute to the inflammatory process of bronchial asthma. According to Dr. Ruprai RK., in the study of the oxidative stress plasma malondialdehyde andascorbic acid (Vitamin C) showed an oxidative imbalance in asthmatic patients and antioxidant supply may have a beneficial impact on the free radical induced injury and improvement of respiratory reserve in Asthmatics(3)(4). In Saudi asthmatic patients, King Saud University study, exhibition of oxidative stress and defective antioxidant status of these patients suggested these may be primary causative factor in the pathogenesis of asthma(5).
In mega doses, vitamin C in asthmatic patients decreased airway hyperreactivity to methacholine, inflammatory cell numbers in brochoalveolar lavage fluid, and moderated reduction of perivascular and peribronchiolar inflammatory cell infiltration(6).

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(a) Vitamin C supplementation for asthma by Kaur B1, Rowe BH, Arnold E.(PubMed)
(b) Vitamin C supplementation for asthma by Ram FS1, Rowe BH, Kaur B(PubMed)
(c) Vitamin C for asthma and exercise-induced bronchoconstriction by Milan SJ1, Hart A, Wilkinson M.(PubMed)
(d) Vitamin C and common cold-induced asthma: a systematic review and statistical analysis by Hemilä H.(PubMed)
(1) Association of antioxidants with allergic rhinitis in children from seoul by Seo JH1, Kwon SO, Lee SY, Kim HY, Kwon JW, Kim BJ, Yu J, Kim HB, Kim WK, Jang GC, Song DJ, Shim JY, Oh SY, Hong SJ.(PubMed)
(2) Blocking effect of vitamin C in exercise-induced asthma by Cohen HA1, Neuman I, Nahum H.(PubMed)
(3) Plasma oxidant-antioxidants status in asthma and its correlation with pulmonary function tests by Ruprai RK.(PubMed)
(4) Antioxidant status in acute asthmatic attack in children by Al-Abdulla NO1, Al Naama LM, Hassan MK.(PubMed)
(5) Oxidative stress and antioxidant status in Saudi asthmatic patients by Al-Afaleg NO1, Al-Senaidy A, El-Ansary A.(PubMed)
(6) Mega-dose vitamin C attenuated lung inflammation in mouse asthmamodel by Jeong YJ1, Kim JH, Kang JS, Lee WJ, Hwang YI.(PubMed)

The Curable smoothie of Tomato, Milk and Green tea for reduced risk and Treatment of Osteoarthritis

Kyle J. Norton(Scholar, master of nutrients), all right reserved
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

The smoothie for people with  Osteoarthritis  and high risk of the disease

Yield: 2 serving (about 8 ounce each)
1 1/2 cups tomatoes
1/2 cup low fat cow milk
1/2 cup green tea drink (Make from 2 grams of green tea, a slice of ginger and a cup of hot water lipped for 5 minutes, and let cool to room temperature)

1. Place tall ingredients in a blender and puree about 1 minute
2. Blend on high speed about 1 minute or until the mixture is thick and the ice is well crushed.
3. Serve immediately

The finding of a natural source for reduced risk and treatment of Osteoarthritis  has encountered many obstacles, many ingredients showed initially the promising result in animal studies have not produced same potentials in either large sample size and mutli centers human trials.
Osteoarthritis (OA), a form of arthritis, is defined as a condition of as a result of aging causes of wear and tear on a joint, affecting over 25 million people in the United States in alone.

Recent studies suggested that the combination of green tea may process a therapeutic values for a potential natural formula used for reduced risk and treatment of Osteoarthritis.

Green tea contains more amount of antioxidants than any drinks or food with the same volume, and is the leaves of Camellia sinensis, undergone minimal oxidation during processing, originated from China.
Green tea polyphenol, significantly slows OA disease progression and alleviate the symptoms of pain, physical stress, and mental stress in post-traumatic osteoarthritis (OA) mouse model, through inhibited expression of pain expression markers and inflammatory cytokines(1).

Other study lead by Dr. Oliviero F also suggested that Epigallocatechin-3-gallate, another major chemical constituent of green tea reduced mononuclear cell infiltration and overexpression of proinflammatory mediators is common in early and late OA through protection or modulation of the inflammatory response to calcium pyrophosphate crystals form deposits in the joint and surrounding tissues(2).
Dr Katiyar SK, and Dr. Raman C. said, "The use of green tea polyphenols may be beneficial as a therapeutic addition to biologics that control IL-1β( a major cytokine driving the inflammatory processes) activity by increasing effectiveness and/or reducing dosage"(3).

Tomato is a red, edible fruit, genus Solanum, belongs to family Solanaceae, native to South America. Because of its health benefits, tomato is grown world wide for commercial purpose
and often in green house.

Tomato, containing high amount of carotenoids, retinol, and tocopherols may also be effective in influence of the development and progression of osteoarthritis (OA)(4). According to the Nagoya University Graduate School of Medicine, lower serum value of beta-/gamma-tocopherols was found to associate to risk of knee OA patients(4) and higher serum of carotenoids may protect against knee OA(5), according to the National Cancer Institute in the study of Two-hundred cases with radiographic knee OA and 200 controls randomly selected from the Johnston County Osteoarthritis Project(5).

Other researchers suggested that daily intake of cow milk may be beneficiary for people over the age of 50 on symptomatic knee OA.(6). The King George Medical University study of 180 knee osteoarthritis (KOA) subjects said," Certain food groups, such as fruits, milk/milk products, and meat/poultry are beneficial for KOA"(7).

Furthermore, the American College of Rheumatology also supported the suggestion of "frequent milk consumption may be associated with reduced OA progression in women". But further studies are necessary to validate replication of these novel findings(8).

Taking altogether, people who are at increased risk of Osteoarthritis  due to family history, gene mutation, aging,.. .....should drink at least one serving daily and people with chronic Osteoarthritis  should drink the juices at least 3 times a day, depending to digestive toleration.
Change life style and diet pattern are also recommended.

All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References

(1) Green tea polyphenol treatment is chondroprotective, anti-inflammatory and palliative in a mouse post-traumaticosteoarthritis model by Leong DJ, Choudhury M, Hanstein R, Hirsh DM, Kim SJ, Majeska RJ, Schaffler MB, Hardin JA, Spray DC, Goldring MB, Cobelli NJ, Sun HB.(PubMed)

(2) Epigallocatechin-3-gallate reduces inflammation induced by calcium pyrophosphate crystals in vitro by Oliviero F1, Sfriso P, Scanu A, Fiocco U, Spinella P, Punzi L.(PubMed)

(3) Green tea: a new option for the prevention or control of osteoarthritis by Katiyar SK, Raman C.(PubMed)

(4) Association of serum carotenoids, retinol, and tocopherols with radiographic knee osteoarthritis: possible risk factors in rural Japanese inhabitants by Seki T1, Hasegawa Y, Yamaguchi J, Kanoh T, Ishiguro N, Tsuboi M, Ito Y, Hamajima N, Suzuki K.(PubMed)

(5) Serum carotenoids and radiographic knee osteoarthritis: the Johnston County Osteoarthritis Project by De Roos AJ1, Arab L, Renner JB, Craft N, Luta G, Helmick CG, Hochberg MC, Jordan JM.(PubMed)

(6) The association of milk consumption with the occurrence of symptomatic knee osteoarthritis by Kaçar C1, Gilgil E, Tuncer T, Bütün B, Urhan S, Sünbüloglu G, Yildirim C, Arikan V, Dündar U, Oksüz MC, Tekeoglu I.(PubMed)

(7) Elucidation of dietary risk factors in osteoarthritis knee—a case-control study by Sanghi D1, Mishra A, Sharma AC, Raj S, Mishra R, Kumari R, Natu SM, Agarwal S, Srivastava RN.(PubMed)

Most Common Diseases of elder: Respiratory Disease: Asthma Treatment: The Effectiveness of Vitamin A

Kyle J. Norton(Scholar and Master of Nutrients)
Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it's news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada - Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Respiratory Disease is defined as medical conditions which affect the breathing organ and tissues including Inflammatory lung disease, Obstructive lung diseases, Restrictive lung diseases, Respiratory tract infections, trachea, bronchi, bronchioles, alveoli, the nerves and muscles breathing , etc,.

                                  Asthma

Asthma is a chronic inflammatory disease affecting the air way of the lung with recurring symptoms, such as wheezing, chest tightness, shortness of breath, and coughing. The disease affects people of all ages, and mostly starts during childhood. In the study of 463,801 children aged 13-14 years in 155 collaborating centres in 56 countries. Children self-reported, through one-page questionnaires, symptoms of these three atopic disorders. In 99 centres in 42 countries, a video asthma questionnaire was also used for 304,796 children, found that for asthma symptoms, the highest 12-month prevalences were from centres in the UK, Australia, New Zealand, and Republic of Ireland, followed by most centres in North, Central, and South America; the lowest prevalences were from centres in several Eastern European countries, Indonesia, Greece, China, Taiwan, Uzbekistan, India, and Ethiopia(1). In the United States, approximately, asthma affects 25 million people, 7 million of them are children.

The effective of Vitamin A against Asthma

Vitamin A is a general term of Vitamin A Retinol, retinal, beta-carotene,alpha-carotene, gamma-carotene, and beta-cryptoxanthin best known for its functions for vision health and antioxidant scavenger and essential for growth and differentiation of a number of cells and tissues.
Recommended intakes of vitamin A, according to the Institute of Medicine of the National Academies (formerly National Academy of Sciences) is 600 µg daily as extremely high doses (>9000 mg) can be toxicity as causes of dry, scaly skin, fatigue, nausea, loss of appetite, bone and joint pains, headaches, etc.
Epidemiological studies linking vitamin A in reduced risk and treatment of asthma have been inconclusive(a)(b)(c)(d)(e), but according to the University G. D'Annunzio, and Respiratory Pathophysiology Center, dietary supplementation or adequate intake of lycopene and vitamin A rich foods may be beneficial in asthmatic subjects(f).

1. Retinols
Serum vitamin A concentrations was found significantly lower in asthmatic subjects than healthy control subjects and administration of all-trans retinoic acid, ATRA dramatically attenuated airway inflammation through inhibiting Th2 and Th17 differentiation and/or functions. according to the Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine(1). ORMDL3 is a candidate gene of childhood onset asthma, and high-transcript of ORMDL3 is associated with the development of asthma. According to Nanjing Medical University, all-trans retinoic acid (ATRA) is an active metabolite of Vitamin A, reduced the risk of asthma through maintained airway epithelial integrity, inhibited asthma effector cells differentiation, modulating immune response, possibly via facilitates ORMDL3 production probable through PKA/CREB(2). Also in all-trans retinoic acid, ATRA, the Tehran University of Medical Sciences study suggested that ATRA diverted the human immune response in neutral conditions (without adding polarizing cytokines) by increasing FOXP3+ cells and decreasing RORγt+ cells(3). In rats with asthma, ATRA was found to alleviate airway hyperresponsiveness and airway remodeling possibly through decreasing the protein expression of MMP-9(4). The study at 1Inserm U700 and Université Paris 7, in a mouse model of ovalbumin (OVA)-induced T helper (Th) 2-type responses and airway remodeling, indicated a effectiveness of liposomally encapsulated ATRA (Lipo-ATRA) in exacerbates allergic immune and inflammatory responses, most likely through promoting Th2 development(5).
Unfortunately, according to Johns Hopkins University, even though animal models suggest that vitamin A deficiency affects lung development adversely and promotes airway hyperresponsiveness, and may predispose to an increased risk of asthma, but vitamin A supplementation early in life was not associated with a decreased risk of asthma in an area with chronic vitamin Adeficiency(6).

2. Carotenoids (beta-carotene, alpha-carotene, gamma-carotene and beta-cryptoxanthin) Carotenoids, plant pigments, converted to vitamin A after intake, play an important role in prevention and treatment of some diseases through it antioxidant effects. In the study of the effect of vitamin intake among asthmatic subject, researchers at the Hung Kuang University, found that nutritional supplement therapy including beta carotene may improve dysregulated oxidant and antioxidant status, inflammation and immune responses, pulmonary function, and health-related quality of life in patients with mild to moderate allergic asthma(7). The John Hunter Hospital study of asthmatic subjects with airway hyper-responsiveness (AHR), indicated a reduced levels of beta-carotene and alpha-tocopherol compared with those without AHR, possibly due to impaired antioxidant defences and are thus most susceptible to the damaging effects of oxidative (8). Other researchers suggested that the imbalance of antioxidants found in asthmatic patients may be the possible causes of the disease(9) and modifying the dietary intake ofcarotenoids alters clinical asthma outcomes with improvements evident only through increased whole foods intake, not supplements(10)
But according to the study of Yamaguchi University, there was no significant association for asthma in Japanese youth(11) and the study of a total of 423 children from a rural area of Thailand, in a Health Interview for AsthmaControl questionnaire, showed no correlation of dietary intake ofcarotenoids between asthmatic and non-asthmatic children(12).

Taken altogether, using vitamin A in prevention and treatment of asthmatic patient remains controversial. According to the study in summarized the important of vitamin A in treatment of asthma, excessive intake of vitamin Amay increase the risk or severity of asthma in industrialized countries whereas vitamin A deficiency continues to increase mortality from infectious diseases in developing countries(12)(13). Overdoses can lead to toxic symptoms. Please make sure you follow the guideline of the Institute of Medicine of the National Academies.


All Forms of Arthritis are Curable
You Can Eliminate Osteoarthritis
By addressing the Underlying Causes through Clinical Trials and Studies

Ovarian Cysts And PCOS Elimination
Holistic System In Existence That Will Show You How To
Permanently Eliminate All Types of Ovarian Cysts Within 2 Months

Back to General health http://kylejnorton.blogspot.ca/p/general-health.html

Back to Kyle J. Norton Home page http://kylejnorton.blogspot.ca

References
(a) Diet and asthma: vitamins and methyl donors by Han YY1, Blatter J1, Brehm JM1, Forno E1, Litonjua AA2, Celedón JC3.(PubMed)
(b) Maternal intake of vitamins A, E and K in pregnancy and child allergic disease: a longitudinal study from the Danish National Birth Cohort by Maslova E, Hansen S, Strøm M, Halldorsson TI, Olsen SF.(PubMed)
(c) Nutritional supplements and plasma antioxidants in childhood asthma byFabian E1, Pölöskey P, Kósa L, Elmadfa I, Réthy LA.(PubMed)
(d) Nutritional supplement therapy improves oxidative stress, immune response, pulmonary function, and quality of life in allergic asthma patients: an open-label pilot study by Guo CH1, Liu PJ, Lin KP, Chen PC(PubMed)
(e) Cod liver oil intake and incidence of asthma in Norwegian adults--the HUNT study by Mai XM1, Langhammer A, Chen Y, Camargo CA Jr.(PubMed)
(f) Plasma lycopene and antioxidant vitamins in asthma: the PLAVA study by Riccioni G1, Bucciarelli T, Mancini B, Di Ilio C, Della Vecchia R, D'Orazio N.(PubMed)
(1) All-trans retinoic acid attenuates airway inflammation by inhibiting Th2 and Th17 response in experimental allergic asthma by Wu J1, Zhang Y, Liu Q, Zhong W, Xia Z.(PubMed)
(2) All-trans retinoic acid modulates ORMDL3 expression via transcriptional regulation by Zhuang LL1, Huang BX, Feng J, Zhu LH, Jin R, Qiu LZ, Zhou GP.(PubMed)
(3) Effect of all-trans retinoic acid (ATRA) on viability, proliferation, activation and lineage-specific transcription factors of CD4+ T cells by Bidad K1, Salehi E, Oraei M, Saboor-Yaraghi AA, Nicknam MH.(PubMed)
(4) [Effects of all-trans retinoic acid on airway responsiveness and airway remodeling in rats with asthma].[Article in Chinese] by Li WK1, Li Y, Zhong LL.(PubMed)
(5) Liposomal retinoic acids modulate asthma manifestations in mice by Maret M1, Ruffie C, Periquet B, Campo AM, Menevret M, Phelep A, Dziewiszek K, Druilhe A, Pretolani M.(PubMed)
(6) Supplementation with vitamin A early in life and subsequent risk ofasthma by Checkley W1, West KP Jr, Wise RA, Wu L, LeClerq SC, Khatry S, Katz J, Christian P, Tielsch JM, Sommer A.(PubMed)
(7) Nutritional supplement therapy improves oxidative stress, immune response, pulmonary function, and quality of life in allergic asthma patients: an open-label pilot study by Guo CH1, Liu PJ, Lin KP, Chen PC.(PubMed)
(8) Reduced circulating antioxidant defences are associated with airway hyper-responsiveness, poor control and severe disease pattern in asthma byWood LG1, Gibson PG.(PubMed)
(9) Antioxidants, oxidative stress, and pulmonary function in individuals diagnosed with asthma or COPD by Ochs-Balcom HM1, Grant BJ, Muti P, Sempos CT, Freudenheim JL, Browne RW, McCann SE, Trevisan M, Cassano PA, Iacoviello L, Schünemann HJ.(PubMed)
(10) Manipulating antioxidant intake in asthma: a randomized controlled trial by Wood LG1, Garg ML, Smart JM, Scott HA, Barker D, Gibson PG.(PubMed)
(11) Association of serum carotenoids and tocopherols with atopic diseases in Japanese children and adolescents by Okuda M1, Bando N, Terao J, Sasaki S, Sugiyama S, Kunitsugu I, Hobara T.(PubMed)
(12) Carotenoid intake and asthma prevalence in Thai children by Rerksuppaphol S1, Rerksuppaphol L.(PubMed)
(13) Vitamin A deficiency decreases and high dietary vitamin A increases disease severity in the mouse model of asthma by Schuster GU1, Kenyon NJ, Stephensen CB.(PubMed)